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PMID: Inflammation. 2016 Aug ;39(4):1483-94. PMID: 27236308 Abstract Title: Lactobacillus rhamnosus GR-1 Limits Escherichia coli-Induced Inflammatory Responses via Attenuating MyD88-Dependent and MyD88-Independent Pathway Activation in Bovine Endometrial Epithelial Cells. Abstract: Intrauterine Escherichia coli infection after calving reduces fertility and causes major economic losses in the dairy industry. We investigated the protective effect of the probiotic Lactobacillus rhamnosus GR-1 on E. coli-induced cell damage and inflammation in primary bovine endometrial epithelial cells (BEECs). L. rhamnosus GR-1 reduced ultrastructure alterations and the percentage of BEECs apoptosis after E. coli challenge. Increased messenger RNA (mRNA) expression of immune response indicators, including pattern recognition receptors (toll-like receptor [TLR]2, TLR4, nucleotide-binding oligomerization domain [NOD]1, and NOD2), inflammasome proteins (NOD-like receptor family member pyrin domain-containing protein 3, apoptosis-associated speck-like protein, and caspase-1), TLR4 downstream adaptor molecules (myeloid differentiation antigen 88 [MyD88], toll-like receptor adaptor molecule 2 [TICAM2]), nuclear transcription factor kB (NF-kB), and the inflammatory cytokines tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, and interferon (IFN)-, was observed following E. coli challenge. However, these increases were attenuated by L. rhamnosus GR-1 pretreatment. Our data indicate that L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of BEECs apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation. Certain probiotics could potentially prevent postpartum uterine diseases in dairy cows, ultimately reducing the useof antibiotics.
ICAN is excited to announce Vanessa Morales as our newest Chapter Leader!
Our local ICAN chapter has been a huge part of my healing journey and an invaluable resource for additional help and knowledge on how to make more informed decisions during pregnancy and birth. ~ Vanessa Morales, ICAN of Central Florida
Please introduce yourself to ICAN:
Ive enjoyed learning about anatomy and physiology for as long as I can remember, which lead me to study exercise science, then radiology. I really enjoyed my career in a patient care environment, but for now, that energy has been switched to caring for my kids. Our family loves to be silly, bake (including conquering dietary challenges in some recipes), dance, and spend time together.
My first birth took place after going into spontaneous labor on a holiday weekend. Several interventions and complications later, I was coerced into a non-emergent cesarean that led to a very traumatic birth and recovery experience due to additional complications that arose during the procedure. My second birth was a homebirth transfer that although it resulted in an emergent cesarean, it was an empowering experience.
What led you to join ICAN?
I initially found the ICAN website while searching for VBAC information online, but didnt start attending the meetings until many months later because I was nervous about sharing my birth story. I knew that I needed to find additional support for how I felt about my sons birth and before I could have another child.
How do you share ICAN as an organization with others?
My strongest belief is that theres not nearly enough conversation happening about potential risks and benefits of both cesareans and VBACs, primarily betwee...
PMID: Benef Microbes. 2017 Apr 26 ;8(2):193-206. Epub 2017 Mar 27. PMID: 28343402 Abstract Title: Probiotic administration improves sperm quality in asthenozoospermic human donors. Abstract: The objective of this study is to analyse the effect of the ingestion of two selected antioxidant probiotics strains (Lactobacillus rhamnosus CECT8361 and Bifidobacterium longum CECT7347) on sperm quality parameters in asthenozoospermic males after three and six weeks of administration. Nine asthenozoospermic men without any medical treatment under similar diet conditions participated in the study. The quality of individual sperm samples was evaluated before (previous to ingestion), during (after 3 and 6 weeks of ingestion) and after probiotic administration (3 and 6 weeks after finishing the treatment). Sperm motility was evaluated by computer-assisted sperm analysis system, DNA fragmentation by sperm chromatin structure assay, cell viability by flow cytometry and measurement of intracellular H2O2 (reactive oxygen species; ROS) by flow cytometry using dichloro-dihydrofluorescein diacetate. Sperm motility was drastically improved after the treatment (approximately 6 fold change), DNA fragmentation was statistically reduced after probiotic administration from (approximately 1.2 fold change) and intracellular H2O2 level was decreased (approximately 3.5 fold change). Cell viability was not affected by the treatment. The significant improvement in sperm motility and the decrease in DNA fragmentation reported in this study provide preliminary evidence that probiotics could be administrated to improve motility and decrease DNA fragmentation and ROS levels in asthenozoospermic human males.
People are very quick to point out that breakfast is the most important meal of the day, but let's face it - it can also be the most rushed and least nutritious. When youve got kids mornings are often chaotic, and its really hard to come up with creative ideas for breakfast when youve got no time and plenty of mouths to feed.
If you feel like you are stuck in a tea and toast breakfast rut and need some inspiration, this is the post youve been looking for.
This is one of my favourite one-handed breakfasts for Newborn Mothers. I discovered it when I created my own recipe book and a very old family friend lent me her favourite nursing mothers book. This page of the book was clearly well used!
I make a double batch in my Thermomix, slice it and freeze it. It defrosts within minutes and is delicious with a cuppa. This has sustained me and my clients on many mornings whilst breastfeeding in a comfy chair.
If you have a new mum friend this is a really great gift!
225g Cheap Dates
175g Flour (I use Atta Flour)
175g Oats (great for your milk supply!)
175g Softened Margarine (I like to use butter)
75 g Sugar (I use unrefined sugar like Rapadura - sometimes called Panela)
2 Tablespoons Cold Water
Preheat your oven to 190C
Put the dates and water in a saucepan and heat for 5 minutes until the dates are mushy. Mash or puree and put aside.
Mix all remaining ingredients to form a dough.
Press half the dough into a greased 20cm x 30cm baking tin. Top with the date mixture and then the remaining dough.
Bake for 30 minutes.
Allow to cool in the tin, then cut and store in the fridge or freezer....
PMID: PLoS One. 2017 ;12(10):e0185964. Epub 2017 Oct 10. PMID: 29016685 Abstract Title: Lactobacillus rhamnosus PB01 (DSM 14870) supplementation affects markers of sperm kinematic parameters in a diet-induced obesity mice model. Abstract: Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L. rhamnosus for four weeks. Sperm motility and kinematics together with blood lipid profiles and reproductive hormone levels were assessed using the sperm class analyzer system. Probiotic supplementation increased serum testosterone, LH and FSH levels in both NW and DIO groups resulting in significantly (P
These findings could lead to something amazing. Have you ever heard of postpartum depression?
Researchers from the University of Granada (UGR) have recently proven that cortisol levels present in the hair of pregnant women during their first or third trimester might be a means of indicating whether or not they will end up suffering from postpartum depression. This study was published in the journal PLOS ONE and showed that the more cortisol, the more likely you were to develop postpartum depression. During each trimester, for this study, each of the women participating underwent a series of tests that evaluated their stress levels as well as their psychopathological symptoms.
Hair samples were taken simultaneously and researchers assessed the levels of cortisol. Just a few days after giving birth the mothers emotional states were evaluated so that they could determine who had come down with postpartum depression and who had not. This led researchers to conclude that participants who had in fact developed postpartum depression showed higher levels of somatization during the first trimester. This leading continuing it increase during the second and third trimester and determined that the cortisol increase was an indicator, definitely.
Since they show that there are various altered psychological and hormonal variables throughout the whole gestation period in comparison to those women who will not suffer postpartum depression. Detecting those differences is the key to anticipate the psychological state of the mother as well as the consequences for the baby that said state could mean.
These findings are important as postpartum depression affects a very large number of women. Psychological symptoms were also consistent with the group of those who developed postpartum depression. This kind of pregnancy-specific stress was also found to be associated with symptoms even after controlling for fetal sex, previous miscarriages, and antenatal depression.
What do you think about these findings? Could there potentially be a hair test for postpartum depression in the future?
Featured image via...
In this episode of Indie Birth Live, we hear Gail Hart talk about her perspective on midwifery licensing.
The post Gail Hart Talks About Midwifery Licensing: INDIE BIRTH LIVE appeared first on Indie Birth.
Over the last few years, evidence-based practice has become a standard expectation of Western health care systems, rather than a topic whose value is debated by clinicians. Concurrently, rules of convention have developed, and it has now become politically correct in some circles to acknowledge in articles whether the author has any interests which might compete with their ability to be objective about the issues discussed.
This is, in principle, a jolly good thing. It is logical to assume that a person whose research (or holiday) is funded by a company manufacturing drug or technology products may feel duty-bound to present those products in a good light. Where objectivity is seen as paramount in producing and evaluating evidence, the well-behaved researcher and clinician will attempt to avoid all bias, or at least declare her bias so that others can decide for themselves whether the information presented may be tainted by the authors interests.
However, it seems we are beginning to realise that there are some problems with this idea. In what appear to be efforts to highlight this, authors of papers in the British Medical Journal have recently declared the following tongue-in-cheek competing interests:
Minnesota Attorney General Lori Swanson says toxic chemicals dumped by 3M Co. in the east metro suburb Oakdale caused higher rates of cancer, infertility and low birthweight babies the first time anyone has estimated the potential human health impact of groundwater contamination in the area since the problem came to light almost two decades ago.
In court briefs filed Friday, Swanson included the conclusions of an expert environmental witness, while alleging that the health and environmental damage of the contamination totals $5 billion and arguing that 3M should be liable for punitive damages.
The states lawsuit against 3M, first filed in 2010, is scheduled for trial early next year after a long series of procedural delays.
The new filings detail allegations that 3M knew the local groundwater was contaminated with chemical compounds known as PFCs years before it stopped making them; that it suppressed the information over the objections of its own scientists; and that it withheld critical information from the U.S. Environmental Protection Agency (EPA).
3M, in pursuit of profit, deliberately disregarded the substantial risk of injury to the people and environment of Minnesota from its continued manufacture of PFCs and its improper disposal, the state said.
In a statement Monday, 3M said Minnesota has not sustained any injuries, let alone over $5 billion in alleged damages.
3M believes these chemicals present no harm at the levels they are observed in Minnesota, said 3Ms lead attorney, William Brewer III.
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