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Friday, 24 August

22:51

Sustained supplementation with vitamin D resulted in a reduced risk of recurrent wheezing by 12 months' adjusted age. "IndyWatch Feed Fertility"

PMID:  JAMA. 2018 05 22 ;319(20):2086-2094. PMID: 29800180 Abstract Title:  Effect of Vitamin D Supplementation on Recurrent Wheezing in Black Infants Who Were Born Preterm: The D-Wheeze Randomized Clinical Trial. Abstract:  Importance: Black infants born preterm face high rates of recurrent wheezing throughout infancy. Vitamin D supplementation has the potential to positively or negatively affect wheezing through modulation of the pulmonary and immune systems.Objective: To assess the effectiveness of 2 vitamin D dosing strategies in preventing recurrent wheezing.Design, Setting, and Participants: A randomized clinical trial enrolled 300 black infants born at 28 to 36 weeks' gestation between January 2013 and January 2016 at 4 sites in the United States, and followed them up through March 2017. Randomization was stratified by site and maternal milk exposure.Interventions: Patients were enrolled prior to discharge from the neonatal intensive care unit or newborn nursery and received open-label multivitamin until they were consuming 200 IU/d of cholecalciferol from formula or fortifier added to human milk, after which they received either 400 IU/d of cholecalciferol until 6 months of age adjusted for prematurity (sustained supplementation) or placebo (diet-limited supplementation). One-hundred fifty three infants were randomized to the sustained group, and 147 were randomized to the diet-limited group.Main Outcomes and Measures: Recurrent wheezing by 12 months' adjusted age was the primary outcome.Results: Among 300 patients who were randomized (mean gestational age, 33 weeks; median birth weight, 1.9 kg), 277 (92.3%) completed the trial. Recurrent wheezing was experienced by 31.1% of infants in the sustained supplementation group and 41.8% of infants in the diet-limited supplementation group (difference, -10.7% [95% CI, -27.4% to -2.9%]; relative risk, 0.66 [95% CI, 0.47 to 0.94]). Upper and lower respiratory tract infections were among the most commonly reported adverse events. Upper respiratory infections were experienced by 84 of 153 infants (54.9%) in the sustained group and 83 of 147 infants (56.5%) in the diet-limited group (difference, -1.6% [95% CI, -17.1% to 7.0%]). Lower respiratory infections were experienced by 33 of 153 infants (21.6%) in the sustained group and 37 of 147 infants (25.2%) in the diet-limited group (difference, -3.6% [95% CI, -16.4% to 4.4%]).Conclusions and Relevance: Among black infants born preterm, sustained supplementation with vitamin D, compared with diet-limited supplementation, resulted in a reduced risk of recurrent wheezing by 12 months' adjusted age. Future research is needed to better understand the mechanisms and longer-term effects of vitamin D supplementation on wheezing in children born preterm.Trial Registration: ClinicalTrial...

21:46

Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. "IndyWatch Feed Fertility"

PMID:  Phytother Res. 2018 Mar ;32(3):514-521. Epub 2017 Nov 28. PMID: 29193350 Abstract Title:  Curcumin nanomicelle improves semen parameters, oxidative stress, inflammatory biomarkers, and reproductive hormones in infertile men: A randomized clinical trial. Abstract:  At least 50% of infertile couple's problems are related to male factor infertility. This Randomized, Double-Blind, Placebo-Controlled Clinical Trial conducted in Urology unit of Infertility Clinic on 60 infertile men. Patients were randomly assigned to one of intervention and placebo (n = 30) groups. Finally, 28 subjects in each group completed the study. Participants in the intervention group took daily 80 mg curcumin nanomicelle and those in the placebo group took daily placebo for 10 weeks. Semen analysis, anthropometric, physical activity assessments, total antioxidant capacity, malondialdehyde, inflammatory factors, and reproductive hormones were measured at the baseline and at the end of the study. At the end of study, statistically significant differences were seen in the total sperm count, sperm concentration, and motility in the intervention group to the controlgroup. In treatment group, the total sperm count, sperm concentration, and motility levels were also statistically increased at the end of study compared to the baseline values. Curcumin nanomicelle supplementation also resulted in a statistically significant improvement in plasma levels of total antioxidant capacity, malondialdehyde, C-reactive protein, and tumor necrosis factor a in comparison to the placebo. Medical therapy of asthenoteratospermia with curcumin nanomicelle supplement could improve quality of semen parameters. However, further investigation is suggested in this regard.

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18:28

Meet the Leadership: Carolin Gharbi, ICAN of the Twin Cities "IndyWatch Feed Fertility"

ICAN is excited to announce Carolin Gharbi as our newest Chapter Leader!

I strongly believe that the way a birthing woman is treated is so incredibly powerful to framing her experience. Respect, informed consent and empowerment should be the cornerstones of any birth! Carolin Gharbi, ICAN of the Twin Cities

Please share a little about yourself.

I am a mom to three kiddos, and actively work as a birth doula for an organization that focuses on improving birth outcomes in the Twin Cities! My educational background/work experience is in International Politics, although that is a life chapter that I have transitioned out of as I found my passion in birth work. I love spending time outside, hiking and exploring nature, trying out new recipes, and various family activities with my husband and kids.

How did you find out about ICAN?

I found out about ICAN after the unplanned/emergency cesarean birth of my first child. I was drawn to the organization because of the resources that were offered as I was searching for evidence based information about cesarean birth, recovery and moving forward, VBAC options and considerations. Finding a place where there were women who had been down a similar path was also helpful!

What part of being an ICAN Chapter Leader are you most excited about and why?

I am excited to come alongside women in our community and serve as a resource, a listening ear, and a comforting presence!

What area does your chapter serve?

ICAN of the Twin Cities, Minnesota. We serve the greater Twin Cities area of Minneapolis and St Paul and surrounding area.

What is the best thing about the birth climate in your area?

The options that mothers have: there are homebirth, birth center and in-hospital birth options for VBAC moms. Family centered, gentle cesarean is the norm at most Twin Cities hospitals.

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