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PMID: Reprod Toxicol. 2018 Oct 25 ;82:103-110. Epub 2018 Oct 25. PMID: 30393182 Abstract Title: Aqueous extract of Eruca Sativa protects human spermatozoa from mitochondrial failure due to bisphenol A exposure. Abstract: Medicinal plants are suggested to counteract health disorders from chemical pollutants. Here we explored the possible ameliorative effect of Eruca sativa aqueous extract (ESAE) on in vitro acute functional disturbance induced by Bisphenol A (BPA), a disruptor model in human spermatozoa. Phytochemical screening, high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC-ESI-MS) analysis and 2,2'-azino-bis [3-ethylbenzthiazoline-6-sulphonic acid]/,-diphenyl--picrylhydrazyl (ABTS/DPPH) tests disclosed antioxidant properties of ESAE, ascribed to polyphenols and flavonoids. The toxicological impact of BPA on sperm viability and motility was detected for concentration greater than 10 M but co-incubation with ESAE recovered sperm functionat low concentration (15.62g/ml). BPA reduced mitochondrial membrane potential (m), with no impact on plasma membrane potential (p). At low doses, ESAE recovered m but higher doses were associated with impairment of both m and p. ESAE protects towards in vitro BPA-mediatedtoxicity and its possible use as complementary treatment for male reproductive disorders is critically discussed.
Few details have been offered on the possible content of the new Magna Carta as pressure groups continue to campaign for same-sex marriage, legal abortion, and a prominent role for communes.
Note: For our London area readers, we invite you to
share this important event with all families of tweens, teens and
young adults. Male and female as the HPV vaccine is being
recommended for males and females alike, despite its launch as a
cervical cancer prevention vaccine. I know we're called
"anti-science" here at AofA, but we DO know boys do not have a
TABERNACLE, NOTTING HILL, London W11 2AY
Conference discussing the controversies surrounding the Human Papillomavirus Vaccine (HPV). Hosted by Research Journalist and Author - Christina England BA Hons and Author - Amanda Dew BSc Hons
Speakers for the day are:
Keynote speaker - Dr. Graham Downing - Consultant healthcare
practitioner with areas of
expertise in Neuro-musculoskeletal & Functional Medicine, with special interest in infection, fertility, endocrine & neuro-developmental disorders
Brandy Vaughan - Ex-Merck pharma rep turned REAL HEALTH
advocate. Founder of LearnTheRisk.org #beBRAVE #betheCHANGE
Leslie Carol Botha - Womans Health Educator and Hormone Expert - USA
Dr. Jayne Donegan MBBS DRCOG DCH DFFP MRCGP MFHom - GP & Homoeopathic Physician with Certified Specialist Accreditation in Medical Homeopathy from the Faculty of Homeopathy, London.
Senta Depuydt - Belgian free-lance journalist in health and education, writing for independent magazines. She organized the premiere of Vaxxed in Brussels, Paris and London in partnership with the EFVV and rallied French lobbyists to oppose new vaccine mandates in France. She is a board member of the French "Ligue Nationale pour la Libert de Vacciner" and of the "European Forum for Vaccine Vigilance".
Anthony Hughes - B.Sc Dip.Chem.Eng., Dip.Stats. & O.R. Licentiate in Traditional Chinese Medicine Clinical Certificate (Nanjiing) China
Juliette Scarfe - Lawyer and Entrepreneur, Organic Formulator, Writer, Speaker, Healer, Holistic Nutritionist UK
Professor Christopher Exley PhD - Keele University - Expert in Aluminum UK (filmed intervie...
While rejoicing over Oregon voters' decisive rejection of a measure that would have left low-income residents and state employees without abortion coverage, reproductive rights advocates prepared for battles in two red states where extremist anti-choice proposals were passed on Tuesday night. In Alabama, the passage of Amendment 2 will give a fetus the same right to life held by a person under the state constitution, paving the way to criminalize abortion with a "trigger ban" like the ones that exist in Louisiana, Mississippi, North Dakota, and South Dakota, should the Supreme Court overturn Roe vs. Wade. Access to contraception and the morning-after pill could also be restricted as a result.
PMID: Zhonghua Yu Fang Yi Xue Za Zhi. 2018 Oct 6 ;52(10):1018-1022. PMID: 30392320 Abstract Title: [Association between early pregnancy bisphenol A exposure and sleep problems among preschool children]. Abstract: To analyze the association between maternal bisphenol A exposure during early pregnancy and sleep problems among preschool children.Research subjects were from one of the sub-cohorts(Ma'anshan Cohort) of the China-Anhui Birth Cohort Study (C-ABCS) in Ma'anshan city. The basic situation of pregnant women and sleep information of preschool children were investigated. We selected preschool children whose mother's maternal serum bisphenol A concentrations of the first trimester had been already detected between December 2012 to Januray 2014. 1 259 pairs of mothers and children were included. The concentrations of bisphenol A exposure during early pregnancy were divided into low, medium and high exposure groups according to 25(th) percentile ((25)) and 75(th) percentile ((75)) levels. Multivariate multinomial logistic regression model was used to analyze the association between maternal bisphenol A exposure during early pregnancy and sleep-related problems in preschool children.The(50) ((25)-(75)) of serum bisphenol A exposure level during early pregnancy was 0.231 (0.106-0.512) ng/ml. The sleep-related problems scores of 1 259 preschool children were (16.433.82) points. The occasional sleep-related problems were detected about 47.8% (602 cases) and frequent sleep-related problems were detected about 18.3% (230 cases). After the adjustment of the confounding factors such as children's gender, age, BMI, sleep position (lying down, sleeping on one's back), the length of time to sleep and the length of sleep at night, in comparison with bisphenol A low exposure group, the(95) value of preschool children with occasional sleep-related problems in maternal bisphenol A high exposure group during early pregnancy was 1.44 (1.01-2.06). After the gender stratification, the results showed that in comparison with bisphenol A low exposure group, the(95) value of preschool girls with occasional sleep-related problems in maternal bisphenol A medium and high exposure group during early pregnancy were 1.61 (1.05-2.46) and 2.40 (1.42-4.04), respectively. The(95) value of preschool girls with frequent sleep-related problems in maternal bisphenol A high exposure group during early pregnancy was 2.64 (1.34-5.17). However, in boys, there was no statistically significant association between maternal bisphenol A exposure during early pregnancy and sleep-related problems (0.05).Maternal bisphenol A exposure during early pregnancy might be related to sleep-related problems in preschool children.
PMID: Arch Toxicol. 2018 Oct 29. Epub 2018 Oct 29. PMID: 30374679 Abstract Title: Acrylamide aggravates cognitive deficits at night period via the gut-brain axis by reprogramming the brain circadian clock. Abstract: Imbalance of the circadian rhythm leads to pathologies including obesity, neurodegenerative diseases, and even cancer. Acrylamide (ACR) is a chronic neurotoxin which can lead to carcinogenicity, reproduction toxicity, teratogenicity, and neurotoxicity. The aim of this study was to reveal a potential mechanism of ACR-triggered neurotoxicity related to circadian clock in mice brain. For this purpose, 80 3-month-old C57/BL6J mice were randomly divided into two groups (n=40/group): the control group was fed a standard diet (AIN-93M) with pure water, and the ACR group was fed a standard diet (AIN-93M) with 0.003% ACR in drinking water for 16 weeks. In the current study, ACR treatment induced circadian disorder and suppressed the circadian-related protein expressions in mice brain. Furthermore, ACR diet aggravated the cognitive dysfunction and spatial memory loss at night phase. Consistent with these results, ACR caused cognitive defects in the night period by down-regulating the ERK/cAMP response element-binding protein (CREB)/brain-derived neurotrophicfactor (BDNF) signaling pathways and the expression of synaptosomal-related protein SNAP-25 and PSD-95. Moreover, excessive autophagy phenomenon also occurred in mice hippocampus in the night phase under ACR administration. Of note, ACR stimulated the brain inflammatory reaction via affecting the intestinal barrier integrity and increasing the levels of circulating LPS, IL-1 and TNF-. Above all, the present research discovered that ACR is a potential circadian-depressing compound that influences cognitive function in mice brain.
I had such high hopes this morning necessary reagent had arrived, I had a nice egg sac, I was going to open it up and spend my afternoon exploring embryos. It was not to be. I teased apart the egg sac, and what do I find? Heartbreak. Disappointment. Failure.
The eggs were all dead. Im not sure what happened here, but I have a hypothesis: this summer and early fall, I had all these fish tanks in the lab, gurgling away, and the place was pretty humid. Now those are shut down, and its winter in Minnesota, when the air dries out. Spiders like some degree of humidity, and Ive been maintaining that by regularly misting their vials with an atomizer, but maybe thats not enough for the embryos.
So Im cranking up the moisture levels in the incubator. Now Ive got to worry about balancing everything too much and Ill have to worry about mold and fungus.
Babies are such fussy little creatures.
Headlines and titles send strong messages to the public about the reported findings from twin research: Twins Separated at Birth Reveal Staggering Influence of Genetics, How Genes Shape Personality, Born That Way, Are We Hardwired?, Mean Genes, Twin Brothers Separated at Birth Reveal Striking Genetic Similarities, Life of Crime Is in the Genes, Study Says, Study Raises the Estimate of Inherited Intelligence, The Gene Bomb, and so on. Pulitzer Prize winning author Lawrence Wright, in his 1997 book about twin studies and behavioral genetic research Twins: And What They Tell Us About Who We Are, wrote that the science of behavioral genetics, largely through twin studies, has made a persuasive case that much of our identity is stamped on us from conception; to the extent that our lives seem to be pre-chosenall we have to do is live out the script that is written in our genes.1 The potential impact of these messages on social relations and political policy decisions is enormous. The 2018 movie Three Identical Strangers has brought the study of reared-apart twins (in this case triplets) to a higher level of public awareness.
I have dedicated much of the past two decades to critically examining behavioral genetic and psychiatric genetic theories, which hold that genetic factors play an important r...
Nichole Rolfe, formerly Nichole Bruff, was a nursing student at Baker College in Michigan who dreamt of being a nurse practitioner of midwifery before the nursing departments director dismissed hershortly before she was to graduateafter Rolfe questioned instructors who were teaching students to lie to patients in order to coerce them into getting vaccinated. UPDATE: 
The post Nursing student dismissed for refusal to lie about vaccines has case continue in court appeared first on Health Nut News.
By Fiona Mackenzie, Cromdale, Grantown on Spey, Highlands of ScotlandChelsea: HPV vaccine survivor from Scotland
Chelsea had 2 injections of Cervarix in the fall of 2012 before we went to Australia. A few months after we returned, we took her in for the third jab. The GP practice stated that they didnt stock Cervarix any longer, but would check whether they could use Gardasil to finish the series. The next week in May 2013 she had her final vaccination, but it was Gardasil, not Cervarix. I did not question this because I trusted the doctor to protect her health. However, looking back I had so little information to go on at the time, I certainly should have questioned the decision to mix the two HPV vaccines. Until after the third injection, Chelsea was a normal healthy girl.
In late August of the same year, she started complaining of back pain. At first, I discounted it but 3 weeks later it had become so serious we had to take her back to the doctor. She was referred for physio, but it did not help. As time went on, Chelsea b...
Photo by Senghak Lee
I sit in a rustic wooden house adorned with ornaments from South Asia in the middle of the wilderness in Bulgaria. It is a chilly night but inside, the atmosphere is warm. I sit in a circle with twelve new Bulgarian friends. Everyone has brought a vegan dish to this Friday night gathering. There is no wine or weed in sight. We all hold hands and OM for several long minutes before we eat.
I have decided to volunteer in the home of a young Bulgarian family for one month. The nearest road is kilometres away and we are surrounded by thick green forestry. The mother of the house spent five years travelling around the world, before deciding that she wanted to settle down and have babies. These were her exact words to me. She talks about Nepal like she encountered a talking Yeti there, and I am 90 per cent sure that my Nepali ethnicity is the only reason why they accepted me as a volunteer.
The father barely speaks and spends seven hours a day making digeridoos although he has never been to Australia. I wonder if he knows the deep cultural significance of the instrument. They have two cats who like to bring me dead mice as gifts and play with their prizes on my bed. They live with their friend who is an assistant to a shaman in Peru who does ayahuasca ceremonies. She parades around proclaiming words of healing and love, but I learn in time that she is actually a deeply insecure and mean woman.
The family has radical beliefs. They do not believe in vaccination and take the baby to the doctor in Sofia every month to fake his vaccinations. The mother had a home birth in a kiddie pool, which is illegal in Bulgaria, and then ate the placenta blended into a smoothie.
At least eight of my twelve new friends have been to Nepal multiple times. When I introduce myself as Nirvana from Nepal, their eyes widen and they sing to me, Ohhhhh I love Nepal. Nirvana, we have been searching for you our entire lives. I politely laugh, because I know this gives them pleasure.
After we eat, everyone takes an instrument and make beautiful music together while I sit and gawk. Usually in such a situation, I would be overcome with gratitude a...
My halocarbon oil arrived today! Finally, I can do some arthropod embryo culture.
Would you believe that 100mL bottle cost me $166? Since Im going to use a 20l drop for each embryo, that means I only have enough for 5000 experiments. Im already feeling a little panicky about my supplies running low. Maybe I should order another bottle.
In case you were wondering what this precious stuff is, its an inert, high molecular weight polymer of chlorotrifluoroethylene. Its used a lot in insect culture because you can put an embryo into a drop of it, and it prevents it from drying out, improves optical clarity, and also allows for free gas exchange. Im eager to try it.
P.S. Oh, right, Im also voting first thing in the morning, and then hiding from all the media about the election all day long.
It's very worrying to be told you have signs of an incompetent cervix. The goal for every woman is to have a healthy pregnancy and give birth when her baby is full term. But signs of an incompetent cervix can change that.
Certified Birth & Bereavement Doula serving Lafayette, Louisiana
Certified Birth & Bereavement Doula serving Cincinnati Ohio
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IndyWatch Fertility and Family Feed was generated at Community Resources IndyWatch.
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