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Saturday, 17 February

05:14

Prevention Against Gallstones - Eat More Foods With Vitamin E "IndyWatch Feed Health"

More than 90 percent of the population does not meet their recommended daily allowance of vitamin E. Researchers in Germany led by the University of Kiel found that subjects with gallstone disease had lower blood levels of vitamin E than those who did not have gallstones.

00:38

Sulforaphane exerts protective effects on microglia and modulates the microglial activation state. "IndyWatch Feed Health"

PMID:  Front Immunol. 2018 ;9:36. Epub 2018 Jan 23. PMID: 29410668 Abstract Title:  Sulforaphane Inhibits Lipopolysaccharide-Induced Inflammation, Cytotoxicity, Oxidative Stress, and miR-155 Expression in Murine Microglial Cells. Abstract:  Sulforaphane (SFN) is a natural product with cytoprotective, anti-inflammatory, and antioxidant effects. In this study, we evaluated the mechanisms of its effects on lipopolysaccharide (LPS)-induced cell death, inflammation, oxidative stress, and polarization in murine microglia. We found that SFN protects N9 microglial cells upon LPS-induced cell death and suppresses LPS-induced levels of secreted pro-inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6. SFN is also a potent inducer of redox sensitive transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), which is responsible for the transcription of antioxidant, cytoprotective, and anti-inflammatory genes. SFN induced translocation of Nrf2 to the nucleusextracellular signal-regulated kinase 1/2 (ERK1/2) pathway activation. siRNA-mediated knockdown study showed that the effects of SFN on LPS-induced reactive oxygen species, reactive nitrogen species, and pro-inflammatory cytokine production and cell death are partly Nrf2 dependent. Mox phenotype is a novel microglial phenotype that has roles in oxidative stress responses. Our results suggested that SFN induced the Mox phenotype in murine microglia through Nrf2 pathway. SFN also alleviated LPS-induced expression of inflammatory microRNA, miR-155. Finally, SFN inhibits microglia-mediated neurotoxicity as demonstrated by conditioned medium and co-culture experiments. In conclusion, SFN exerts protective effects on microglia and modulates the microglial activation state.

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00:19

Why I spoke out against (the HPV) vaccine "IndyWatch Feed Health"

February 15, 2018: Letter to Hackney Gazette from Councillor Harvey Odze regarding HPV vaccines reprinted with authors permission.

Cllr Harvey Odze (Conservative, Springfield) writes:

I refer to your report on page 7 of the February 1 edition, where you quoted me as having said at the full council meeting on January 24:

Given the considerable body of medical evidence that HPV does not cause cervical cancer; and that the vaccine is on its way to becoming the 21st centurys Thalidomide, can you assure me all parents are given full information about the dangers of the vaccine?

I was asking Cllr Jonathan McShane, the cabinet member for health, social care and devolution, a supplementary question following on from Cllr Jessica Webbs question asking the cabinet member if we can extend the Human Papilloma Virus vaccination programme to boys.

Due to the boorish, undemocratic behavior of a group of Labour councillors, your reporter was unfortunately unable to hear the totallity of my question. So, in order to put the record straight, what I in fact asked was:

Given that there is a considerable body of peer reviewed medical evidence that Human Papilloma Virus does not cause cervical cancer and that the Human Papilloma Virus vaccine is well on its way to becoming the 21st century Thalidomide, except that Thalidomide, had it not had such disastrous side effects, would have been an effective vaccine, will the cabinet member consult the UK Association of Human Papilloma Virus Vaccine Injured Daughters (AHVID) and ensure that all parents are given full information about the dangers of the vaccine as well as its alleged advantages?

This significantly alters the balance of my question.

Since your report I have been inundated with emails of thanks and support for publicly highlighting this issue. If anyone wishes to find more information I suggest they see Joan Shentons three-part documentary series Sacrificial Virgins and the short documentary Manufactured Crisis: HPV, Hype and Horror Trailer 4.

I would suggest that any parents of injured girls who have not already done so contact AHVID, who will give them support in any way they can.

The post Why I spoke out against (the HPV) vaccine appeared first on...

00:18

Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. "IndyWatch Feed Health"

PMID:  Free Radic Biol Med. 2018 Feb 7. Epub 2018 Feb 7. PMID: 29427794 Abstract Title:  Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Abstract:  Diabetes and cardiometabolic disorders such as hypertension and obesity are major risk factors for the development of cardiovascular disease, with a wealth of evidence suggesting that oxidative stress is linked to the initiation and pathogenesis of these disease processes. With yearly increases in the global incidence of cardiovascular diseases (CVD) and diabetes, numerous studies have focused on characterizing whether upregulating antioxidant defenses through exogenous antioxidants (e.g. vitamin E, vitamin C) or activation of endogenous defenses (e.g. the Nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant defense pathway) may be of benefit. The dietary isothiocyanate sulforaphane (SFN) is currently the subject of several clinical trials for a variety of disease states, including the evaluation of its therapeutic potential to ameliorate diabetic and cardiometabolic complications. SFN is a well characterized and potent Nrf2 inducer, however recent studies suggest its protective actions may be in part mediated by its modulation of various pro-inflammatory (e.g. Nuclear factor-kappa B (NFB)) and metabolic (e.g. Peroxisome Proliferator-Activator Receptor Gamma (PPAR)) signaling pathways. The focus of this review is to provide a detailed analysis of the known mechanisms by which SFN modulates Nrf2, NFB and PPAR signaling and crosstalk and to provide a critical evaluation of the evidence linking these transcriptional pathways with diabetic and cardiometabolic complications and SFN mediated cytoprotection. To allow comparison between rodent and human studies, we discuss the published bioavailability of SFN metabolites achieved in rodents and man in the context of Nrf2, NFB and PPAR signaling. Furthermore, we provide an update on the functional outcomes and implicated signaling pathways reported in recent clinical trials with SFN in Type 2 diabetic patients.

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00:05

Sulforaphane metabolites cause apoptosis via microtubule disruption in cancer. "IndyWatch Feed Health"

PMID:  Endocr Relat Cancer. 2018 Mar ;25(3):255-268. PMID: 29431641 Abstract Title:  Sulforaphane metabolites cause apoptosis via microtubule disruption in cancer. Abstract:  Sulforaphane (SFN) inhibited growth in many cancers, but its half-life is 2h in circulation. However, its metabolites, sulforaphane-cysteine (SFN-Cys) and sulforaphane-N-acetyl-cysteine (SFN-NAC) had longer half-lives and decreased the cell viability in both dose- and time-dependent manners in human prostate cancer. Flow cytometry assay revealed that these two SFN metabolites induced apoptosis with the features such as vacuolization, disappeared nuclear envelope, nuclear agglutination and fragmentation via transmission electron microscopy observation. Western blot showed that the sustained phosphorylation of ERK1/2 mediated by SFN metabolites caused activation andupregulation of cleaved Caspase 3 and downregulation of -tubulin. High expression of -tubulin was demonstrated to be positively correlated with cancer pathological grading. Both co-immunoprecipitation and immunofluorescence staining implicated the interaction between SFN metabolite-induced phosphorylated ERK1/2 and -tubulin, and Caspase 3 cleavage assay showed that -tubulin might be the substrate for cleaved Caspase 3. More, the SFN metabolite-mediated reduction of -tubulin increased the depolymerization and instability of microtubules by microtubule polymerization assay. Reversely,microtubule-associated protein Stathmin-1 phosphorylation was increased via phosphorylated ERK1/2 and total Stathmin-1 was reduced, which might promote over-stability of microtubules. Immunofluorescence staining also showed that SFN metabolites induced the 'nest-like' structures of microtubule distribution resulting from the disrupted and aggregated microtubules, and abnormal nuclear division, suggesting that the disturbance of spindle formation and mitosis turned up. Thus, SFN-Cys and SFN-NAC triggered the dynamic imbalance of microtubules, microtubule disruption leading to cell apoptosis. These findings provided a novel insight into the chemotherapy of human prostate cancer.

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Friday, 16 February

23:44

Ursolic acid derivatives as potential antidiabetic agents. "IndyWatch Feed Health"

PMID:  Drug Dev Res. 2018 Jan 29. Epub 2018 Jan 29. PMID: 29380400 Abstract Title:  Ursolic acid derivatives as potential antidiabetic agents: In vitro, in vivo, and in silico studies. Abstract:  Hit, Lead&Candidate Discovery Protein tyrosine phosphatase 1B (PTP-1B) has attracted interest as a novel target for the treatment of type 2 diabetes, this because its role in the insulin-signaling pathway as a negative regulator. Thus, the aim of current work was to obtain seven ursolic acid derivatives as potential antidiabetic agents with PTP-1B inhibition as main mechanism of action. Furthermore, derivatives 1-7 were submitted in vitro to enzymatic PTP-1B inhibition being 3, 5, and 7 the most active compounds (IC = 5.6, 4.7, and 4.6 M, respectively). In addition, results were corroborated with in silico docking studies with PTP-1B orthosteric site A and extended binding site B, showed that 3 had polar and Van der Waals interactions in both sites with Lys120, Tyr46, Ser216, Ala217, Ile219, Asp181, Phe182, Gln262, Val49, Met258, and Gly259, showing a docking score value of -7.48 Kcal/mol, being more specific for site A. Moreover, compound 7 showed polar interaction with Gln262 and Van der Waals interactions with Ala217, Phe182, Ile219, Arg45, Tyr46, Arg47, Asp48, and Val49 with a predictive docking score of -6.43 kcal/mol, suggesting that the potential binding site could be localized in the site B adjacent to the catalytic site A. Finally, derivatives 2 and 7 (50 mg/kg) were selected to establish their in vivo antidiabetic effect using a noninsulin-dependent diabetes mice model, showing significant blood glucose lowering compared with control group (p 

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23:29

Ursolic acid atenuates high glucose-mediated mesangial cell injury. "IndyWatch Feed Health"

PMID:  Med Sci Monit. 2018 Feb 11 ;24:846-854. Epub 2018 Feb 11. PMID: 29428962 Abstract Title:  Ursolic Acid Attenuates High Glucose-Mediated Mesangial Cell Injury by Inhibiting the Phosphatidylinositol 3-Kinase/Akt/Mammalian Target of Rapamycin (PI3K/Akt/mTOR) Signaling Pathway. Abstract:  BACKGROUND To investigate the protective effect of ursolic acid (UA) on high glucose (HG)-induced human glomerular mesangial cell injury and to determine whether UA inhibits cell proliferation and reactive oxygen species (ROS) production by suppressing PI3K/Akt/mTOR pathway activation. MATERIAL AND METHODS Human mesangial cells were cultured with normal glucose (NG group), high glucose (HG group), mannitol (mannitol hypertonic control group), or high glucose with different concentrations (0.5, 1.0, and 2.0 mmol/L) of UA (HG+UA groups). Cell proliferation and intracellular ROS levels were assessed by methyl thiazolyl tetrazolium (MTT) and dichloro-dihydro-fluorescein diacetate (DCFH-DA) flow cytometry assays, respectively. Western blotting was used to detect mesangial cell expression of PI3K/Akt/mTOR pathway components, including Akt, p-Akt, mTOR, and p-mTOR, and proteins related to cell injury, including TGF-1 and fibronectin (FN). mRNA expression of TGF-1 and FN were evaluated using real-time quantitative polymerase chain reaction (PCR). RESULTS Abnormal proliferation was observed in human glomerular mesangial cells at 48 h after treatment with HG, and UA suppressed the HG-induced proliferation ofmesangial cells in a dose-dependent manner. UA inhibited ROS generation and oxidative stress in mesangial cells and mitigated mesangial cell injury. Treatment with UA reduced Akt and mTOR phosphorylation levels in mesangial cells exposed to HG (p

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22:43

Ursolic acid activates the apoptosis of prostate cancer. "IndyWatch Feed Health"

PMID:  Oncol Lett. 2018 Mar ;15(3):3202-3206. Epub 2017 Dec 27. PMID: 29435058 Abstract Title:  Ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated mitochondrial translocation of cofilin-1. Abstract:  Ursolic acid has various pharmacological activities, and can reduce blood fat as well as having antihepatic, antitumoral, anti-inflammatory and antiviral properties. However, the pro-apoptotic mechanism by which ursolic acid influences human prostate cancer requires additional study. The aim of the present study was to assess whether ursolic acid activates the apoptosis of prostate cancer and to investigate the mechanism by which the Rho-associated protein kinase 1 (ROCK1)/phosphatase and tensin homolog (PTEN) signaling pathway performs a role in ursolic acid-mediated cofilin-1 to induce apoptosis in human prostate cancer. Firstly, the present study determined the pro-apoptotic mechanism by which ursolic acid influences the cell proliferation and apoptosis of human prostate LNCaP cancer cells. Caspase-3/9 activities and ROCK1, PTEN, Cofilin-1 and cytochrome c protein expression levels were also analyzed. In the present study, it is reported that the pro-apoptotic mechanism of ursolic acid potently suppressed the cell proliferation of human prostate LNCaP cancer cells. The present study revealed that the mediation of ROCK1/PTEN-cofilin-1/cytochrome c protein expression activates caspase-3/9 activities which subsequently induced the apoptosis of human prostate cancer cells. In conclusion, these findings demonstrated that ursolic acid activates the apoptosis of prostate cancer via ROCK/PTEN mediated cofilin-1/cytochrome c which mediated caspase-3/9 activities.

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22:17

Time-traveller claiming to be from 2030 PASSES a lie detector test after claiming that Donald Trump will be re-elected and Artificial Intelligence will take over "IndyWatch Feed Health"

Wouldnt it be great if we could go back in time? We could change the things from our past, stop mistakes before they happen, maybe even save the world. Unfortunately that kind of technology doesnt exist yet, but what about in the future? Well, a new video that has gone viral may prove the existence... View Article

The post Time-traveller claiming to be from 2030 PASSES a lie detector test after claiming that Donald Trump will be re-elected and Artificial Intelligence will take over appeared first on Healthy Holistic Living.

22:16

California Christian Homeschool Family Torn Apart as Children are Medically Kidnapped, Forced into Public School, and Mother is Forced out of Family Home "IndyWatch Feed Health"

Erin This is the shot from the Whidbey Island Bridge ( Point Deception) This is about an hour before he spiked the temp

This photo of the Daugherty family was taken on the Whidbey Island Bridge in Washington while the family was on vacation. Photo supplied by family.

by Health Impact News/MedicalKidnap.com Staff

When the Daugherty family decided to visit Seattle, Washington, for a 4 day whale watching trip to celebrate their sons 10th birthday, they had no idea that a trip to the emergency room would turn into a nightmare that would rip their family apart.

They were more than a thousand miles from home and from their own doctors, when chronically ill Zachary began running a fever and showing signs of an infection.

When his parents took him to the emergency room at Seattle Childrens Hospital, they blindly walked into a web of controversy involving some of the most notorious Child Abuse Specialist doctors in the country, with connections to Medical Kidnap stories we have published spanning from Boston to Arizona, California, and Washington.

California parents Kevin and Erin Daugherty learned that the conflict between Boston area doctors involved with the notorious Justina Pelletier case didnt stay in Boston. It has spread all the way from the East Coast to the West Coast of America. Their son Zachary has been caught in the crossfire of differing philosophies of different doctors.

There is a dangerous trend occurring today involving parents with children with multiple medical issues (medically complex) or children with mysterious conditions that doctors havent figured out how to diagnose yet.

While the concerned parents often have to search for doctors with the expertise to help their children, that very concern is used to accuse them of Munchausen Syndrome by Proxy or Factious Disorder, or the more common term now used in child social services Medical Child Abuse a general all-purpose term used by doctors in the relatively new field of Child Abuse Specialists when parents dare to disagree with them.

Parents versus Doctors The Fight for Ame...

22:12

Heres How to Turn Your Babys Clothes Into Keepsake Memory Bears "IndyWatch Feed Health"

The teddy bear you see below started out as a onesie. It was made out of a crafting project called memory bear, where your babys onesie can be turned into a cuddle buddy once theyve outgrown that cute outfit. Its a great keepsake for moms especially if it holds a special memory, like a hospital... View Article

The post Heres How to Turn Your Babys Clothes Into Keepsake Memory Bears appeared first on Healthy Holistic Living.

22:10

40+ Things Every Mom and Daughter Should Do Together At Least Once "IndyWatch Feed Health"

Nothing beats mother-daughter bonding moments that we can cherish forever. From simple nothings to extravagant activities, theyre always worth the fun because its in the company of someone we love. Here are 50 ideas that mothers and daughters can do to spend quality time together. Stay at Home Activities You can do a number of... View Article

The post 40+ Things Every Mom and Daughter Should Do Together At Least Once appeared first on Healthy Holistic Living.

22:08

Phenethyl isothiocyanate and ursolic acid protects DNA from oxidative damage. "IndyWatch Feed Health"

PMID:  Mol Nutr Food Res. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29383876 Abstract Title:  Histone Methyltransferase Setd7 Regulates Nrf2 Signaling Pathway by Phenethyl Isothiocyanate and Ursolic Acid in Human Prostate Cancer Cells. Abstract:  SCOPE: This study aimed to investigate the role of the epigenetic regulator SET domain-containing lysine methyltransferase 7 (Setd7) in regulating the antioxidant Nrf2 pathway in prostate cancer (PCa) cells and examined the effects of two phytochemicals, phenethyl isothiocyanate (PEITC) and ursolic acid (UA).METHODS AND RESULTS: Lentivirus-mediated shRNA knockdown of Setd7 in LNCaP and PC-3 cells decreased the expression of downstream Nrf2 targets, such as NAD(P)H: quinone oxidoreductase 1 (Nqo1) and glutathione S-transferase theta 2 (Gstt2). Down-regulation of Setd7 decreased soft agar colony formation ability of PCa cells. Knockdown of Setd7 increased reactive oxygen species (ROS) generation. Furthermore, Setd7 knockdown attenuated Nqo1 and Gstt2 expression in response to HOchallenge, whereas increased DNA damage was observed in Setd7 knockdown cells in comet assay. Interestingly, Setd7 expression could be induced by the dietary phytochemicals PEITC and UA. Chromatin immunoprecipitation (ChIP) assays showed that Setd7 knockdown decreased H3K4me1 enrichment in the Nrf2 and Gstt2 promoter regions, while PEITC and UA treatments elevated the enrichment.CONCLUSION: Taken together, these results indicate that Setd7 knockdown decreases Nrf2 and Nrf2-target genes expression and that PEITC and UA induce Setd7 expression, which activates the Nrf2/antioxidant response element (ARE) signaling pathway and protects DNA from oxidative damage. This article is protected by copyright. All rights reserved.

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22:04

Dads Everywhere: We Need to Talk About Your 20-Minute Poop Breaks "IndyWatch Feed Health"

MOTHERS: KEEP READING Theres a nationwide possibly global problem frustrating moms every and it needs to be addressed. Meet Elle Beattie, an Australian award-winning radio producer and mother of 1-year-old baby boy, Lang. Now more than ever, she is your fellow mom-in-arms whos spearheading the problem and has gone viral doing so! Elle... View Article

The post Dads Everywhere: We Need to Talk About Your 20-Minute Poop Breaks appeared first on Healthy Holistic Living.

21:40

California Christian Homeschool Family Torn Apart as Children are Medically Kidnapped, Forced into Public School, and Mother is Forced out of Family Home "IndyWatch Feed Health"

Erin This is the shot from the Whidbey Island Bridge ( Point Deception) This is about an hour before he spiked the temp

This photo of the Daugherty family was taken on the Whidbey Island Bridge in Washington while the family was on vacation. Photo supplied by family.

by Health Impact News/MedicalKidnap.com Staff

When the Daugherty family decided to visit Seattle, Washington, for a 4 day whale watching trip to celebrate their sons 10th birthday, they had no idea that a trip to the emergency room would turn into a nightmare that would rip their family apart.

They were more than a thousand miles from home and from their own doctors, when chronically ill Zachary began running a fever and showing signs of an infection.

When his parents took him to the emergency room at Seattle Childrens Hospital, they blindly walked into a web of controversy involving some of the most notorious Child Abuse Specialist doctors in the country, with connections to Medical Kidnap stories we have published spanning from Boston to Arizona, California, and Washington.

California parents Kevin and Erin Daugherty learned that the conflict between Boston area doctors involved with the notorious Justina Pelletier case didnt stay in Boston. It has spread all the way from the East Coast to the West Coast of America. Their son Zachary has been caught in the crossfire of differing philosophies of different doctors.

There is a dangerous trend occurring today involving parents with children with multiple medical issues (medically complex) or children with mysterious conditions that doctors havent figured out how to diagnose yet.

While the concerned parents often have to search for doctors with the expertise to help their children, that very concern is used to accuse them of Munchausen Syndrome by Proxy or Factious Disorder, or the more common term now used in child social services Medical Child Abuse a general all-purpose term used by doctors in the relatively new field of Child Abuse Specialists when parents dare to disagree with them.

Parents versus Doctors The Fight for Americas Chil...

21:29

A combination of phenethyl isothiocyanate and TH588 has potential as a novel therapeutic strategy against pancreatic cancer. "IndyWatch Feed Health"

PMID:  Oncol Lett. 2018 Mar ;15(3):3240-3244. Epub 2017 Dec 29. PMID: 29435064 Abstract Title:  TH588, an MTH1 inhibitor, enhances phenethyl isothiocyanate-induced growth inhibition in pancreatic cancer cells. Abstract:  Chemotherapy and radiotherapy are the most common approaches in cancer therapy. They may kill cancer cells through the generation of high levels of reactive oxygen species (ROS), which leads to oxidative DNA damage. However, tumor resistance to ROS is a problem in cancer therapy. MTH1 sanitizes oxidized dNTP pools to prevent the incorporation of damaged bases during DNA replication. Although MTH1 is non-essential in normal cells, cancer cells require MTH1 activity to avoid the incorporation of oxidized dNTPs, which would result in DNA damage and cell death. By targeting a redox-adaptation mechanism, MTH1 inhibition represents a novel therapeutic strategy against cancer. However, recent reports have indicated that growth inhibition by MTH1 inhibitors may be due to off-target cytotoxic effects. TH588, one of the first-in-class MTH1 inhibitors, kills cancer cells by an off-target effect. However, a low concentration of TH588 may effectively inhibit MTH1 activity without inhibiting cell proliferation. Phenethyl isothiocyanate (PEITC) is a dietary anticarcinogenic compound and an inducer of ROS. In the present study, it has been demonstrated that combined treatment with PEITC and TH588 effectively inhibited the growth of pancreatic cancer MIAPaCa-2 and Panc-1 cells. The antioxidant N-acetylcysteine negated this synergistic growth inhibition. PEITC and TH588 cooperatively induced the formation of 8-oxo-deoxyguanine in nuclei and pH2AX foci, a marker of DNA damage. However, the combined effects are not associated with MTH1 mRNA expression in several cancer cell lines, suggesting that the possibility of an off-target effect of TH588 cannot be eliminated. These results suggest that the combination of PEITC and TH588 has potential as a novel therapeutic strategy against pancreatic cancer.

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20:46

Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate in lung cancer cells. "IndyWatch Feed Health"

PMID:  Mol Carcinog. 2017 Dec 26. Epub 2017 Dec 26. PMID: 29278657 Abstract Title:  Inhibition of autophagy potentiates the anti-metastasis effect of phenethyl isothiocyanate through JAK2/STAT3 pathway in lung cancer cells. Abstract:  Phenethyl isothiocyanate (PEITC) is a natural compound abundant in cruciferous vegetables. PEITC possesses anti-tumor effect in various human malignances. Our previous study has shown that benzyl isothiocyanates (BITC) induce autophagy in lung cancer cells. However, whether autophagy play a role in the inhibitory effect of PEITC on lung cancer metastasis is unclear. In this study, we found that PEITC suppressed migration and invasion of lung cancer cells by regulating MMP2. It also induced autophagy, evidenced by the formation of acidic vesicular organelles (AVOs), the punctate pattern of LC3, the accumulation of LC3-II, and the expression of Beclin-1. Inhibition of autophagy by 3-MA and chloroquine (CQ) or knock down of Beclin-1 enhanced PEITC-caused metastasis inhibition. JAK2/STAT3 pathway was suppressed by PEITC, and further inhibited by 3-MA and CQ or Beclin-1 knock down, as a result of decreased expression of p-JAK2 and p-STAT3. Blocking JAK2/STAT3 pathway by inhibitor AG490 and Stattic suppressed cell migration and decreased the expression of MMP2, MMP9, Twist, and c-Myc. Further in vivo study showed that PEITC inhibited tumor growth, induced autophagy and suppressed JAK2/STAT3 pathway, and inhibitor CQ enhanced this effect. Taken together, our results demonstrate that PEITC inhibits metastasis potential of lung cancer cells, and induces autophagy. The autophagy induced by PEITC preserves metastasis potential of lung cancer cells, via activation of JAK2/STAT3 pathway. Inhibition of autophagy enhanced the inhibitory effect of PEITC on metastasis potential of lung cancer cells. Our finding suggests that targeting autophagy could be a promising strategy for anti-metastasis therapies.

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19:59

Shikonin inhibits cell growth and induces apoptosis in different types of breast cancer cells. "IndyWatch Feed Health"

PMID:  Sci Rep. 2018 Feb 8 ;8(1):2672. Epub 2018 Feb 8. PMID: 29422643 Abstract Title:  RNA-seq transcriptome analysis of breast cancer cell lines under shikonin treatment. Abstract:  Shikonin is a naphthoquinone isolated from the dried root of Lithospermum erythrorhizon, an herb used in Chinese medicine. Although several studies have indicated that shikonin exhibits antitumor activity in breast cancer, the mechanism of action remains unclear. In the present study, we performed transcriptome analysis using RNA-seq and explored the mechanism of action of shikonin in regulating the growth of different types of breast cancer cells. The ICof shikonin on MCF-7, SKBR-3 and MDA-MB-231 cells were 10.3, 15.0, 15.0 respectively. Our results also demonstrated that shikonin arrests the progression of cell cycle and induces apoptosis in MDA-MB-231 cells. Using RNA-seq transcriptome analysis, we found 38 common genes that significantly express in different types of breast cancer cells under shikonin treatment. In particular, our results indicated that shikonin induces the expression of dual specificity phosphatase (DUSP)-1 and DUSP2 in both RNA and protein levels. In addition, shikonin also inhibits the phosphorylation of JNK and p38, the downstream signaling molecules of DUSP1 and DUSP2. Therefore, our results suggest that shikonin induces the expression of DUSP1 and DUSP2 which consequently switches off JNK and p38 MAPK pathways and causes cell cycle arrest and apoptosis in breast cancer cells.

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19:19

Cell Phone Radiation is Unlikely to Cause Cancer: Fact or Fiction? "IndyWatch Feed Health"

According to the World Bank about three quarters of people on the planet now use a cell phone. So they must be safe, right? Wrong

Most people have some notion that cell phones communicate with one another and with cell phone towers by emitting and receiving radiation; radio frequency radiation to be more precise.

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19:15

Media is Ignoring This One Crucial Factor in Florida School Shooting "IndyWatch Feed Health"

Source: Media is Ignoring This One Crucial Factor in Florida School Shooting For more content like this visit REALfarmacy.com.

by DAVID KUPELIAN Here we go again. A horrific mass shooting occurs. Everyone is in shock and grief. Democrats blame guns and Republicans. Pundits urge the public, If you see something, say something. And everyone asks, Why? As information about the perpetrator emerges, a relative confides to a newspaper that the troubled youth who committed []

Source: Media is Ignoring This One Crucial Factor in Florida School Shooting Learn more at REALfarmacy.com - Healthy News and Information.

18:21

Melanie Gaydos: The Model with Ectodermal Dysplasia Redefining Beauty Standards "IndyWatch Feed Health"

For decades if not centuries, the modelling world catered to a specific kind of beauty. In recent years, however, 28-year-old model Melanie Gaydos is one of a growing number of alternative models collectively challenging the status quo and definition of beauty standards. How Melanie Gaydos Is Transforming the Fashion Industry It was not always photographers... View Article

The post Melanie Gaydos: The Model with Ectodermal Dysplasia Redefining Beauty Standards appeared first on Healthy Holistic Living.

18:18

The Most Important Lesson You Need To Learn This Year Based On Your Zodiac Sign "IndyWatch Feed Health"

2018 may have just started, but it already feels like its flying by. Every new year brings new challenges for us, so we better arm ourselves accordingly. Heres what you need to know for 2018, based on your zodiac sign. Lessons From Your Zodiac Sign Aries (March 21 April 19) Being an Aries, youre... View Article

The post The Most Important Lesson You Need To Learn This Year Based On Your Zodiac Sign appeared first on Healthy Holistic Living.

18:16

The Link Between Verbal Abuse and Anxiety That No One Talks About "IndyWatch Feed Health"

When you hear the term abuse, what are some of the first words or images that come to mind? Many people probably think of words like violence, beating, and hitting or images of fighting and abusive familial relationships. However, there is one type of abuse that often goes ignored verbal abuse and it... View Article

The post The Link Between Verbal Abuse and Anxiety That No One Talks About appeared first on Healthy Holistic Living.

18:11

Grandparents Never Die- They Become Invisible Everyone Must Read This Its Heartwarming! "IndyWatch Feed Health"

Growing up, our grandparents were our heroes. They were the ones we would turn to when we were upset with our parents, and they would always take your side. Theyre always there with a story to tell us, or a lesson when we need guidance. They are like a parent that you could call your... View Article

The post Grandparents Never Die- They Become Invisible Everyone Must Read This Its Heartwarming! appeared first on Healthy Holistic Living.

17:52

These Dog Foods Have Been Recalled Because They May Contain EUTHANASIA DRUGS "IndyWatch Feed Health"

By Daisy Luther

***SEE THE UPDATE FOR MORE RECALLS***

Do you feed your dogs wet food? If so, you need to check your labels because 4 major brands have been recalled by the manufacturer, J.M. Smucker Company.

According to a message sent to retailers, the foods could contain a drug that is used in euthanasia.

The J.M. Smucker Company is initiating a voluntary withdrawal of a limited quantity of Gravy Train, Kibbles N Bits, and SkippyWet Dog Food products after learning specific SKUs did not meet our specifications because a minor ingredient may contain low levels of pentobarbital. This is not a threat to pet safety. Although the extremely low levels do not present a health or safety risk, their presence in our products is not acceptable to us. (source)

In a different article, the brand Ol Roy was also included in the list of recalled brands.

Pentobarbital in pet foods can cause death.

Despite reassurances that the tainted food doesnt present a risk, a previous pentobarbital taint caused the death of one familys beloved pet. Nikki Mael shared her tragic story.

Within minutes of sharing a can of Evangers pet food among her five dogs, she was racing the lifeless animals to the emergency vet.

...

17:23

Family Members Say Florida School Shooter Was On Antidepressants for Emotional Issues "IndyWatch Feed Health"

By Rachel Blevins

Parkland, Florida At least 17 people were killed and 15 were wounded during a mass shooting at a high school in Florida on Wednesday, and the reports that have been released about the suspect indicate that he was taking medications for depression and emotional issues that come packed with dangerous side effects.

Nikolas Cruz, 19, is accused of entering Marjory Stoneman Douglas High School and opening fire on his fellow students after he was previously expelled for disciplinary reasons that have not been made public. The Miami Herald reported that Cruz has raised red flags at school in the past, and last year a teacher submitted a warning against letting him on campus with a backpack.

Former classmates said they were not surprised by the shooting. Joshua Charo told the Herald that Cruz fit the description of a disgruntled student who would carry out a mass shooting.

I cant say I was shocked, Charo said. From past experiences, he seemed like the kind of kid who would do something like this.

John Crescitelli shared the same sentiment, saying his son had warned him about Cruz before. If you were to pick one person you might predict in the future would shoot up a school or do this, it would be this kid, he said.

An Instagram account attributed to Cruz that was taken down after the shooting showed a number of photos that displayed his love for guns, knives and killing small animals and rodents.

...

16:39

Top Tips to Decrease Your Breast Cancer Risk "IndyWatch Feed Health"

Source: Top Tips to Decrease Your Breast Cancer Risk For more content like this visit REALfarmacy.com.

By Dr. Mercola Breast cancer is probably one of the most feared diagnoses a woman can get. The mere mention of it conjures up images of death, despair, or at best, disfigurement. According to breastcancer.org,1 one in eight women will develop invasive breast cancer in her lifetime, and nearly 40,000 women lose their lives to []

Source: Top Tips to Decrease Your Breast Cancer Risk Learn more at REALfarmacy.com - Healthy News and Information.

15:44

Ultra-Processed Food Linked to Cancer "IndyWatch Feed Health"

processed food cancer

By Brandon TurbevilleNatural Blaze

A new study by French researchers is drawing attention to the possible links between processed foods and cancer.

The study, which classified foods such as mass produced bread, chicken nuggets, and cakes as ultra processed, looked at 105,000 people, showed results which suggest that the more ultra-processed foods people eat, the greater their risk of cancer.

Diet, of course, is already known to affect the risk of cancer, with obesity being heavily linked to cancer rates. Processed meat has also shown an increase in rates of cancer.

Foods considered ultra processed include:

  • Mass-produced packaged breads and buns
  • Sweet or savory packaged snacks inclu...

15:30

FDA Bans Triclosan and 23 Other Antiseptics from Healthcare Products "IndyWatch Feed Health"

By Heather CallaghanEditor

Triclosan, and to a lesser extent, other antiseptics, have gone through a well-deserved pruning process with the FDA.

But its not quite over yet. In 2015, the FDA determined that anti-bacterial soaps were no more effective than regular soap. In fact, triclosan the former active ingredient in many antibacterial products required up to 9 hours to break down bacteria cell walls. However, the substance was corrosive to organs and linked to other serious health problems, putting the consumer, and especially the healthcare worker, at great personal risk.

In 2016, the FDA ordered antibacterials like triclosan out of soaps and gave companies one year to reformulate. Note: Im still seeing antibacterial soaps for sale online with this ingredient for some reason. Most companies voluntarily removed it from soap, thanks to consumer health awareness. But the chemical remained in the healthcare field. In late 2017, the FDA issued a full-out ban on the marketing of OTC healthcare products containing triclosan and other antiseptics on their hit-list.

Despite triclosan being implicated in the rise of antibiotic-resistance and considered an environmental hazard the chem...

15:11

Pharma Says Opioid Vaccine On The Way "IndyWatch Feed Health"

Pharma giveth and pharma taketh; and sometimes, it does both at the exact same time. While faced with a public backlash over opioid addiction, pharmas solution is now to create a vaccine that will allegedly stop...

The post Pharma Says Opioid Vaccine On The Way appeared first on Vaxxter.

12:03

Puerto Ricos Mental Health Crisis (Podcast) "IndyWatch Feed Health"

From The New York Times: Months after Hurricane Maria devastated Puerto Rico, the island is experiencing a severe mental health crisis. Public health officials say much of the population shows signs of post-traumatic stress.

Podcast 

12:02

Drug Treatment of ADHD Tenuous Scientific Basis "IndyWatch Feed Health"

From Tidsskriftet: Over the past three decades, there has been a dramatic increase in the diagnosis and pharmacological treatment of ADHD. Recent systematic reviews reveal a weak evidence base for the use of pharmaceutical drugs in the treatment of children and adolescents diagnosed with ADHD.

Article

12:01

Psychiatrys Little Known Role in Creating the Holocaust "IndyWatch Feed Health"

From NewBostonPost: In light of the recent commemoration of International Holocaust Remembrance Day, it is important to acknowledge the role that eugenics, a field developed by psychiatrists and psychologists, played in creating the Holocaust.

The recent commemoration of International Holocaust Remembrance Day reminds us to consider the causes of the Nazi genocide. Hitler found justification for his racism in the pseudo-science of eugenics, which means good genes or good race. Eugenics was developed by psychiatrists and psychologists long before the Third Reich. According to The Master Race, an article in Boston Magazine, Massachusetts was one of its epicenters, beginning at a time when Hitler was an aimless Austrian barely in his teens. Eugenics had its roots in the beginning of psychology; it grew strong in America; and its ripest fruit was produced in Nazi Germany.

In 2010 the president of the German Association for Psychiatry and Psychotherapy, Dr. Frank Schneider, admitted and apologized for German psychiatrys leading role in the Holocaust. He said, Under National Socialism [Nazism], psychiatrists showed contempt for their fellow man. They lied to and deceived the patients in their care and their families. They forced them to be sterilized, arranged their deaths, and even performed killings. His apology made headlines in Germany but didnt get mainstream coverage in the United States or the rest of the world.

Article

11:59

I Used to Be Psychotic and Then I Heard a Voice Again "IndyWatch Feed Health"

So there I was, some 16 years or so since I last heard voices that were labelled as psychosis, and then I had another experience. I heard my name being called out from a street cafeI couldnt see anyone attached to the voice.

Having had a look around from where I was standing, I slowly took a few steps backwards towards the cafe, just to see who it was that had called my name. Alas, I could not see who it was.

What I did notice is that all the people in the cafe had appeared not to notice my name being called out. Fortunately, I was not overly concerned but perhaps a little surprised by this clear and concise calling of my name.

As I walked on, I heard the voice again. The voice was familiar, and this time I was able to put a name to the voice. When I realized who the voice was, I became unconcerned by the voice being present and continued my way.

The explanation for hearing the voice last week outside the cafe is quite straightforward and does not represent anything unusual or concerning: I had been awake for 36 hours and had spent the past 12 hours in a highly significant, humbling and deeply humane relational and emotional reality. But what if I had not been able to make sense of such an experience? What if I could not make sense of the experience of hearing the voice (especially as the voice was actually comforting given the previous few days and weeks)? And, what was the relationship between the voice I heard this week and the voices I heard all those years agoif any?

The reason this experience interested me so much is due to a number of factors, not the least of which was my personal journey of working in mental health environments that have the biomedical stamp all over them. Choosing to stand up and speak out with alternatives to the dominant discourse has come with considerable attack, allegation, agitation and threat. I have been subject to countless statements about my supposed lack of understanding, my actions increasing risk, nonsense about being anti-psychiatry, nonsense about being anti-medicationthe list goes on. This kind of vulnerability is of course not a new experience for people that have spoken out before me. But it is unfounded and rather unpleasant for me, and sadly speaks to a dominant discourse that is not founded in science, compassion, humanity or dignity, but using power as an apparent truth. The fact that I have lived experience is broadly accepted in the public mental health system where i work. The sad reality, however, is the prejudice and stereotyping that lies dormant, except for the odd occasion when people cannot contain their underlying views that a person who has previously been psychotic, diagnosed with a disorder, might just not really ever be okay. These stereotypes do inform the views of workers. More concerning is the potential consequences of the stereotypes if I returne...

11:41

Shikonin inhibits migration and invasion of thyroid cancer cells. "IndyWatch Feed Health"

PMID:  Med Sci Monit. 2018 Feb 1 ;24:661-670. Epub 2018 Feb 1. PMID: 29389913 Abstract Title:  Shikonin Inhibites Migration and Invasion of Thyroid Cancer Cells by Downregulating DNMT1. Abstract:  BACKGROUND Shikonin is a component of Chinese herbal medicine. The aim of this study was to investigate the effects of shikonin on cell migration of papillary thyroid cancer cells of the TPC-1 cell line in vitro and expression levels of the phosphate and tensin homolog deleted on chromosome 10 (PTEN) and DNA methyltransferase 1 (DNMT1) genes. MATERIAL AND METHODS The Cell Counting Kit-8 (CCK-8) assay was performed to evaluate the proliferation of TPC-1 papillary thyroid cancer cells, and the normal thyroid cells, HTori-3, in vitro. A transwell motility assay was used to analyze the migration of TPC-1 cells. Western blot was performed to determine the expression levels of PTEN and DNMT1 genes. A methylation-specific polymerase chain reaction (PCR) (MSP) assay was used to evaluate the methylation of PTEN. RESULTS Following treatment with shikonin, the cell survival rate of TPC-1 cells decreased in a dose-dependent manner; the inhibitory effects on HTori-3 cells were less marked. Shikonin inhibited TPC-1 cell migration and invasion in a dose-dependent manner. The methylation of PTEN was suppressed by shikonin, which also reduced the expression of DNMT1 in a dose-dependent manner, and increased the expression of PTEN. Overexpression of DNMT1 promoted the migration of TPC-1 cells and the methylation of PTEN. Levels of protein expression of PTEN in TPC-1 cells treated with shikonin decreased, and were increased by DNMT1 knockdown. CONCLUSIONS Shikonin suppressed the expression of DNMT1, reduced PTEN gene methylation, and increased PTEN protein expression, leading to the inhibition of TPC-1 cell migration.

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11:19

These results provide in-depth insight into the mechanisms of action of shikonin in the treatment of cancer. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2018 Feb ;15(2):1484-1492. Epub 2017 Dec 5. PMID: 29434733 Abstract Title:  Shikonin causes apoptosis by disrupting intracellular calcium homeostasis and mitochondrial function in human hepatoma cells. Abstract:  Shikonin is known to suppress proliferation and induce apoptosis in a variety of cancer cell lines. In the present study, SMMC-7721 human hepatocellular carcinoma cells were treated with shikonin (1, 2 or 4M) for 12-48 h. Cell morphological alterations and DNA damage were determined. Furthermore, changes in cell cycle, mitochondrial transmembrane potential, calcium homeostasis and levels of reactive oxygen species were measured. Shikonin-treated SMMC-7721 cells exhibited morphological changes and DNA damage. Shikonin inhibited cell proliferation causing cell cycle arrest at the G/Gphase and induced apoptosis in a dose- and time-dependent manner. Shikonin-induced apoptosis was associated with activation of caspases-3, -8 and -9, elevated levels of intracellular Caand reactive oxygen species, reduced mitochondrial membrane potential and enhanced efflux of Caand K. Gene expression B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), p53 and caspase-3 was up-regulated, whereas Bcl-2 expression was downregulated. Shikonin caused apoptosis by inhibiting cell cycle progression, disrupting Cahomeostasis, inducing oxidative stress and triggering mitochondrial dysfunction. Activation of caspases-3, -8 and -9, Kefflux, and regulation of Bax, Bcl-2, p53 and caspase-3 expression are involved in the process. These results provide in-depth insight into the mechanisms of action of shikonin in the treatment of cancer.

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08:17

The use of wavelength-exclusion filters in biophotonic measurement can be employed to detect cancer in vitro. "IndyWatch Feed Health"

PMID:  Biochem Biophys Rep. 2018 Mar ;13:7-11. Epub 2017 Nov 20. PMID: 29202105 Abstract Title:  Biophotonic markers of malignancy: Discriminating cancers using wavelength-specific biophotons. Abstract:  Early detection is a critically important factor when successfully diagnosing and treating cancer. Whereas contemporary molecular techniques are capable of identifying biomarkers associated with cancer, surgical interventions are required to biopsy tissue. The common imaging alternative, positron-emission tomography (PET), involves the use of nuclear material which poses some risks. Novel, non-invasive techniques to assess the degree to which tissues express malignant properties are now needed. Recent developments in biophoton research have made it possible to discriminate cancerous cells from normal cells both in vitro and in vivo. The current study expands upon a growing body of literature where we classified and characterized malignant and non-malignant cell types according to their biophotonic activity. Using wavelength-exclusion filters, we demonstrate that ratios between infrared and ultraviolet photon emissions differentiate cancer and non-cancer cell types. Further, we identified photon sources associated with three filters (420-nm, 620-nm., and 950-nm) which classified cancer and non-cancer cell types. The temporal increases in biophoton emission within these wavelength bandwidths is shown to be coupled with intrisitic biomolecular events using Cosic's resonant recognition model. Together, the findings suggest that the use of wavelength-exclusion filters in biophotonic measurement can be employed to detect cancer in vitro.

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08:00

Practicing super brain yoga reduced the symptoms of hyperactivity disorder among the school-age children. "IndyWatch Feed Health"

PMID:  Perspect Psychiatr Care. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29427513 Abstract Title:  Effectiveness of super brain yoga for children with hyperactivity disorder. Abstract:  PURPOSE: This study aimed at determining the effectiveness of super brain yoga for children with hyperactivity disorder.DESIGN AND METHOD: This quasiexperimental and interventional research was conducted on 80 school-age children through a pretest-posttest design.RESULTS: Results showed that there was a significant difference between the means of severity of hyperactivity disorder before (75.1) and after the intervention (63.5) (p 

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07:54

A review of yoga and immune system functioning. "IndyWatch Feed Health"

PMID:  J Behav Med. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29429046 Abstract Title:  Yoga and immune system functioning: a systematic review of randomized controlled trials. Abstract:  Yoga is an ancient mind-body practice that is increasingly recognized to have health benefits in a variety of clinical and non-clinical conditions. This systematic review summarizes the findings of randomized controlled trials examining the effects of yoga on immune system functioning which is imperative to justify its application in the clinic. Fifteen RCTs were eligible for the review. Even though the existing evidence is not entirely consistent, a general pattern emerged suggesting that yoga can downregulate pro-inflammatory markers. In particular, the qualitative evaluation of RCTs revealed decreases in IL-1beta, as well as indications for reductions in IL-6 and TNF-alpha. These results imply that yoga may be implemented as a complementary intervention for populations at risk or already suffering from diseases with an inflammatory component. Beyond this, yoga practice may exert further beneficial effects by enhancing cell-mediated and mucosal immunity. It is hypothesized that longer time spans of yoga practice are required to achieve consistent effects especially on circulating inflammatory markers. Overall, this field of investigation is still young, hence the current body of evidence is small and for most immune parameters, more research is required to draw distinct conclusions.

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07:42

Regular stretching exercise of Thai yoga in combination with exercises could promote health-related physical fitness. "IndyWatch Feed Health"

PMID:  J Altern Complement Med. 2018 Feb 13. Epub 2018 Feb 13. PMID: 29437484 Abstract Title:  The Effects of Thai Yoga on Physical Fitness: A Meta-Analysis of Randomized Control Trials. Abstract:  OBJECTIVES: Thai yoga is a traditional Thai exercise used for improving health-related physical fitness. Many studies have evaluated these effects, but their results remain inconclusive. This meta-analysis aimed to examine the effectiveness of Thai yoga on physical fitness.DESIGN/METHODS: PubMed, EMBASE, CINAHL, Cochrane library, Thai Library Integrated System (ThaiLis), Physiotherapy Evidence Database (PEDro), National Rehabilitation Information Center (Rehabdata), Scopus, Web of Science, Thai University library databases/journals, and Thai Physical Therapy database up to March 2016 were searched for randomized controlled trials (RCTs) examining the effect of Thai yoga exercise compared with normal daily activities as controls, in any language. The weighted mean difference (WMD) and 95% confidence intervals (95% CI) were performed using the random-effects model.RESULTS: Seven RCTs met the inclusion criteria. Thai yoga training significantly improved body flexibility by 3.9cm after 4 weeks [95% CI=3.9-4.0; p

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07:25

Allicin alleviated lipid metabolism disorder induced by 1,3-DCP. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2017 Dec ;96:1411-1417. Epub 2017 Nov 21. PMID: 29169723 Abstract Title:  Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Abstract:  Allicin (2-propene-1-sulfinothioic acid S-2-propenyl ester), with quite a good range of hepatoprotective and antineoplastic properties, is a functional substance from garlic (Allium sativum L.) The purpose of this study was to provide evidence that allicin could protect 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Allicin reduced the accumulation of triglycerides (TG) and total cholesterol (TC) in 1,3-DCP-induced HepG2 cells. Allicin significantly increased the phosphorylation of AMP-activated protein kinase (AMPK) and down-regulated the levels of sterol regulatory element binding protein-1 (SREBP-1) and sterol regulatory element binding protein-2 (SREBP-2) in 1,3-DCP-induced HepG2 cells. Additionally, allicin had obvious recovery influence on the phosphorylation level of PKA and CREB in 1,3-DCP-induced HepG2 cells. These observations indicated that allicin alleviated lipid metabolism disorder induced by 1,3-DCP in HepG2 cells by regulating AMPK-SREBPs and PKA-CREB signaling pathways.

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07:09

Allicin ameliorates cognitive impairment in APP/PS1 mice. "IndyWatch Feed Health"

PMID:  Tissue Cell. 2018 Feb ;50:89-95. Epub 2017 Dec 2. PMID: 29429523 Abstract Title:  Allicin ameliorates cognitive impairment in APP/PS1 mice via Suppressing oxidative stress by Blocking JNK Signaling Pathways. Abstract:  In middle and old age, Alzheimer's disease (AD) is a progressive neurodegenerative disorder of brain. As an increasingly aging population, AD represents a huge burden for the patients' family and the country. However, current therapeutical strategies have shown limited effectiveness. Allicin, which is the main composition of garlic, was reported to prevent the learning and memory impairment of AD mouse model. As the mechanism is not clear, in this study, we used the APP (amyloid precursor protein)/PS1 (presenilin 1) double transgenic mice, which express human mutant APP and PS1, to determine the protective effect of allicin on neurons. AD involves a broad range of clinical, cellular, and biochemical manifestations. This has led to many views of AD, e.g. the amyloid, presenilin, oxidative stress, and mitochondrial dysfunction. We confirmed that allicin improves the cognitive function of APP/PS1 double transgenic mice by reducing the expression levels of A, oxidative stress, and improving mitochondrial dysfunction. Application of behavioral, morphological and molecular biology, and other means were conducted to investigate the effect of allicin, which provide an experimental basis for the reliable application of allicin in the treatment of neurodegenerative diseases.

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07:00

All Homeopathic Products Now Illegal? "IndyWatch Feed Health"

Source: All Homeopathic Products Now Illegal? For more content like this visit REALfarmacy.com.

By Dr. Mercola About 5 million U.S. adults and 1 million U.S. children use homeopathy every year, and the remedies are known to be generally safe and unlikely to cause severe adverse reactions, according to the U.S. National Institutes of Healths National Center for Complementary and Integrative Health.1 Yet, if the U.S. Food and Drug []

Source: All Homeopathic Products Now Illegal? Learn more at REALfarmacy.com - Healthy News and Information.

07:00

How to Grow Sage "IndyWatch Feed Health"

By Dr. Mercola

Known for its woolly oblong leaves and musky smell, sage (Salvia officinalis) is one of the easiest herbs to grow. While its ornamental varieties are also popular, sage is best known in its culinary form as a complement to poultry and other meat dishes. In the U.S., a mention of sage is likely to evoke memories of Thanksgiving turkey and stuffing, two dishes in which sage often features prominently.

Beyond its culinary uses, sage has medicinal value to aid digestion, boost cognitive function, manage diabetes and treat inflammation, among others. Fortunately, it is one of the easiest perennial herbs to grow. If you are able to provide plenty of sunshine, good drainage and air circulation, you should consider growing sage.

Options for Starting Sage

Starting sage plants couldnt be easier, and you have three options:1,2

Seed: Sage seed must be sown while fresh. Not only does it not store well, but also, even when the seed is fresh, sage is a relatively slow and poor germinator. When planting indoors, place three seeds in a cell to ensure you get a decent amount of viable seedlings.

Root cuttings: You can grow another sage plant by clipping a 3-inch portion from the very tip of an existing mature stem and placing it in moist potting mix or vermiculite. In about six weeks, roots will emerge. Another option is layering,3 which involves securing a bendable stem from an existing plant to the ground using a piece of wire or rocks.

Before covering it with dirt, make a small nick in the bent stem where you want the roots to grow. You can wait a couple of months or a whole season before separating the new plant from the original.

Transplants:4 If you want to get a head start on the growing season, plant sage seeds in a starter soil mix and maintain them under grow lights for six to eight weeks before the last frost in your area. The seeds will take about three weeks to germinate. Another option is to purchase established transplants from your local garden center or nursery.

...

Start Your Parsley Plants Indoors "IndyWatch Feed Health"

By Dr. Mercola

Whether you prefer curly or flat varieties, parsley is more than a garnish or natural breath freshener. Rich in vitamins K, A and C, as well as minerals like calcium and iron, parsley can be easily grown outdoors when ground temperatures are above 50 degrees F, or indoors year-round. Despite being a slow germinator, parsley does well when maintained in moist, well-drained soil with decent sun exposure.

Parsley is packed with flavonoids and volatile oils known to provide numerous health benefits. This nutrient-rich herb has been shown to act as a diuretic, aid diabetes management, build strong bones, fight cancer, reduce inflammation and strengthen your immune system. Parsley can be incorporated into fresh vegetable juice, blended into smoothies, used to season a variety of foods and transformed into a cleansing tea. Whatever your pleasure, give parsley a try.

Parsley: An Ancient Herb

Parsley (Petroselinum crispum) has a long, rich history, dating back 2,000 years.1,2 It originated in the central Mediterranean region. Later, it became naturalized to other areas of Europe. Today, parsley is grown widely and available worldwide as a fresh herb or dried spice. As a member of the Apiaceae (or Umbelliferae) family, parsley makes its home among other aromatic herbs such as anise, coriander, cumin, dill and fennel, as well as vegetables like carrots, celery and parsnips.

Parsley was highly prized by ancient Greeks, who incorporated it into crowns and wreaths. They also used parsley in burial rituals and hung it on tombs. The Romans initially used parsley as a medicinal plant and later consumed it as a food. The use of parsley as a seasoning is believed to have caught on during the Middle Ages. The curly variety was more popular initially because the flat-leaf type could easily be confused for fools parsley, a poisonous weed.

Today, parsley is used as an herb, green leafy vegetable and spice. Parsley leaf and root are not only popular in European and Mediterranean cuisines, but also have found their way into a variety of international cuisines. Beyond being an attractive garnish, parsley adorns salads, enlivens stocks and...

06:52

Allicin induces apoptosis through activation of both intrinsic and extrinsic pathways in glioma cells. "IndyWatch Feed Health"

PMID:  Mol Med Rep. 2018 Feb 2. Epub 2018 Feb 2. PMID: 29436625 Abstract Title:  Allicin induces apoptosis through activation of both intrinsic and extrinsic pathways in glioma cells. Abstract:  Allicin is an extract purified from Allium sativum (garlic), and previous research has indicated that Allicin has an inhibitory effect on many kinds of tumor cells. The aim of the present study was to explore the anticancer activity of Allicin on human glioma cells and investigate the underlying mechanism. MTT and colony-formation assays were performed to detect glioma cell proliferation, and explore the effect of Allicin at various doses and time-points. The apoptosis of glioma cells was measured by fluorescence microscopy with Hoechst 33258 staining, and then flow cytometry was used to analyzed changes in glioma cell apoptosis. Reverse transcriptionquantitative polymerase chain reaction and western blot analysis were used to detect the effect of Allicin on the expression levels of Fas/Fas ligand (FasL), caspase3, Bcell lymphoma 2 and Bcl2associated X protein. Allicin suppressed the proliferation and colony formation ability of U251 cells in a dose and timedependent manner. A cytotoxic effect of Allicin was observed in glioma cells in a dosedependent manner. Changes in nuclear morphology were observed in U251 cells with Hoechst 33258 staining. The activity of caspases were significantly elevated and Fas/FasL expression levels were increased following treatment with Allicin, at both the mRNA and protein level. These results demonstrated that Allicin suppresses proliferation and induces glioma cell apoptosis in vitro. Both intrinsic mitochondrial and extrinsic Fas/FasLmediated pathways react in glioma cell after treating with Allicin, which then activate major apoptotic cascades. These results implicate Allicin as a novel antitumor agent in treating glioma.

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06:38

Polyphenols have potential use in the prevention and treatment of cardiovascular diseases. "IndyWatch Feed Health"

PMID:  Curr Pharm Des. 2018 Jan 29. Epub 2018 Jan 29. PMID: 29384050 Abstract Title:  Polyphenols: Potential Use In The Prevention And Treatment Of Cardiovascular Diseases. Abstract:  BACKGROUND: Polyphenols are bioactive compounds that can be found mostly in foods like fruits, cereals, vegetables, dry legumes, chocolate and beverages such as coffee, tea and wine. They are extensively used in the prevention and treatment of cardiovascular disease (CVD) providing protection against many chronic illnesses. Their effects on human health depend on the amount consumed and on their bioavailability. Many studies have demonstrated that polyphenols have also good effects on the vascular system by lowering blood pressure, improving endothelial function, increasing antioxidant defences, inhibiting platelet aggregation and low-density lipoprotein oxidation, and reducing inflammatory responses.METHODS: This review is focused on some groups of polyphenols and their effects on several cardiovascular risk factors such as hypertension, oxidative stress, atherogenesis, endothelial dysfunction, carotid artery intima-media thickness, diabetes and lipid disorders.RESULTS: It is proved that these compounds have many cardio protective functions: they alter hepatic cholesterol absorption, triglyceride biosynthesis and lipoprotein secretion, the processing of lipoproteins in plasma, and inflammation. In some cases, human long-term studies did not show conclusive results because they lacked in appropriate controls and in an undefined polyphenol dosing regimen.CONCLUSION: Rigorous evidence is necessary to demonstrate whether or not polyphenols beneficially impact CVD prevention and treatment.

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06:07

Studies on prevention of obesity, metabolic syndrome, diabetes, cardiovascular diseases and cancer by tea. "IndyWatch Feed Health"

n/a PMID:  J Food Drug Anal. 2018 Jan ;26(1):1-13. Epub 2017 Dec 1. PMID: 29389543 Abstract Title:  Studies on prevention of obesity, metabolic syndrome, diabetes, cardiovascular diseases and cancer by tea. Abstract:  Tea, a popular beverage made from leaves of the plant Camellia sinensis, has been studied extensively in recent decades for its beneficial health effects in the prevention of obesity, metabolic syndrome, diabetes, cancer, and other diseases. Whereas these beneficial effects have been convincingly demonstrated in most laboratory studies, results from human studies have not been consistent. Some studies demonstrated that weight reduction, alleviation of metabolic syndrome and risk reduction in diabetes were only observed in individuals who consume 3-4 cups of tea (600-900 mg tea catechins) or more daily. This chapter reviews some of these studies, the possible mechanisms of actions of tea constituents, and the challenges in extrapolating laboratory studies to human situations.

05:49

730,000 Filipino Children Receive Faulty Dengue Vaccine Which Causes Dengue Rather Than Preventing it "IndyWatch Feed Health"

Source: 730,000 Filipino Children Receive Faulty Dengue Vaccine Which Causes Dengue Rather Than Preventing it For more content like this visit REALfarmacy.com.

In a story that is being mostly censored in the U.S. media, vaccine manufacturer Sanofi Pasteur has admitted that their vaccine for dengue (a deadly tropical disease spread mostly by mosquitoes) is defective. In a press release from France, the pharmaceutical company admitted that the vaccine is harmful to those not previously infected with dengue, []

Source: 730,000 Filipino Children Receive Faulty Dengue Vaccine Which Causes Dengue Rather Than Preventing it Learn more at REALfarmacy.com - Healthy News and Information.

05:38

may be effectively used in controlling or treating obesity, hyperlipidemia and other related metabolic diseases. "IndyWatch Feed Health"

PMID:  J Food Sci. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29427445 Abstract Title:  Green Tea Polyphenols Modulate Colonic Microbiota Diversity and Lipid Metabolism in High-Fat Diet Treated HFA Mice. Abstract:  : There is an increasing interest in the effect of dietary polyphenols on the intestinal microbiota and the possible associations between this effect and the development of obesity. However, limited information is available on how these polyphenols affect the gut microbiota and lipid metabolism. The co-action of a high-fat diet (HFD) and tea polyphenol (TP) on gut microbiota and lipid metabolism using a human flora-associated (HFA) C57BL/6J mice model is studied. TP reduced serum total cholesterol, triglyceride, low density lipoprotein, glucose (GLU) and insulin (INS) levels of HFD mice in a dose-dependent manner (P

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05:26

The results show the effects and mechanism of Oolong tea to provide cardio-protective benefits during hypoxic conditions. "IndyWatch Feed Health"

PMID:  Environ Toxicol. 2018 Feb ;33(2):220-233. Epub 2017 Nov 15. PMID: 29139225 Abstract Title:  Oolong tea prevents cardiomyocyte loss against hypoxia by attenuating p-JNK mediated hypertrophy and enhancing P-IGF1R, p-akt, and p-Badactivity and by fortifying NRF2 antioxidation system. Abstract:  Tea, the most widely consumed natural beverage has been associated with reduced mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing high levels of catechins, their degree of oxidation varies between 20%-80% causing differences in their active metabolites. In this study we examined the effect of oolong tea extract (OTE) obtained by oxidation at low-temperature for short-time against hypoxic injury and found that oolong tea provides cyto-protective effects by suppressing the JNK mediated hypertrophic effects and by enhancing the innate antioxidant mechanisms in neonatal cardiomyocytes and in H9c2 cells. OTE effectively attenuates 24 h hypoxia-triggered cardiomyocyte loss by suppressing caspase-3-cleavage and apoptosis in a dose-dependent manner. OTE also enhances the IGFIR/p-Akt associated survival-mechanism involving the elevation of p-Badin a dose-dependent manner to aid cellular adaptations against hypoxic challenge. The results show the effects and mechanism of Oolong tea to provide cardio-protective benefits during hypoxic conditions.

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05:18

Fenghuang Oolong teas may have prebiotic-like activity and can be used as functional food components in manipulating intestinal microbiota. "IndyWatch Feed Health"

PMID:  Int J Food Sci Nutr. 2018 Jan 5:1-15. Epub 2018 Jan 5. PMID: 29303032 Abstract Title:  The evaluation of the quality of Feng Huang Oolong teas and their modulatory effect on intestinal microbiota of high-fat diet-induced obesity mice model. Abstract:  The variations in the contents of tea catechins and free amino acids in relation to the quality of Fenghuang Oolong teas (FOT) were determined. It demonstrated that in FOT, which were grown at a high altitude, the contents of methylated estered tea catechins were relatively higher. By human flora-associated (HFA) mice model, the effect of FOT on high-fat diet-induced obesity was investigated by high-throughput sequencing. The shifts in relative abundance of the dominant taxa at the phylum, family and genus levels showed their dramatically effects. A large increase in Bacteroidetes with decrease of Firmicutes was observed after the administration of FOT for 8weeks. Together, these results suggest that FOT are rich in tea catechins, especially O-methylated tea catechin derivatives, which may be affected by the unique growth environment, and FOT may have prebiotic-like activity and can be used as functional food components in manipulating intestinal microbiota.

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05:06

Tea infusions ameliorate cancer in 4TI metastatic breast cancer model. "IndyWatch Feed Health"

PMID:  BMC Complement Altern Med. 2017 Apr 7 ;17(1):202. Epub 2017 Apr 7. PMID: 28388918 Abstract Title:  Tea (Camellia sinensis) infusions ameliorate cancer in 4TI metastatic breast cancer model. Abstract:  BACKGROUND: Tea (Camellia sinensis) infusions are widely consumed beverages with numerous health benefits. However, physiological and molecular responses mediating these activities are poorly understood.METHOD: Three replicates of 4TI cancer cell suspension (2.0  10cells/ml) were challenged in vitro with various concentrations of green, black and purple tea infusions to asseses their cytoxicity and associated differentially expressed genes in the cells. Inhibitory activity was tested by using serial dilutions of respective tea infusions in a 96 well ELISA plate.RESULTS: Green tea had the highest inhibition on 4TI cells proliferation at a concentration of IC = 13.12 g/ml. Further analysis of the 4TI cancer cell line treated with tea using 454 pyrosequencing generated 425,696 reads with an input mean length of 286.54. Trimmed sequences were imported on a CLC genomic workbench v7.03 and annotated on a reference mouse genome (Mus musculus strain C57BL/6 J). Results revealed a differential expression of apoptosis related genes in the transcriptome. Casp8, Casp9, Casp3, Casp6, Casp8AP2, Aifm1, Aifm2 and Apopt1 genes were significantly upregulated indicating the process of apoptosis was initiated and executed.CONCLUSION: These findings on caspases offer valuable information on the mechanism of tea as an anticancer agent and will contribute to further research in future novel treatments.

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04:55

Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats. "IndyWatch Feed Health"

PMID:  J Enzyme Inhib Med Chem. 2005 Aug ;20(4):349-56. PMID: 16206829 Abstract Title:  Keemun black tea extract contains potent fatty acid synthase inhibitors and reduces food intake and body weight of rats via oral administration. Abstract:  The inhibitory effects of a black tea extract on fatty acid synthase were measured through inhibition kinetics. The Keemun black tea extract showed more potent inhibitory activity on fatty acid synthase than green tea extract. Additionally, the inhibitory ability of the black tea extract depended on the extracting solvent and the conditions used. Only 10-23% of the inhibitory activity from the black tea was extracted by the general method of boiling with water. The results suggested that the main fatty acid synthase inhibitors in black tea might be theaflavins. Which were more potent than epigallocatechin gallate or C75. The reaction site on the fatty acid synthase and the inhibition kinetics for the extract were different from those of epigallocatechin gallate or C75. In addition, Keemun black tea extract significantly reduced food intake, body weight and blood triglyceride of diet-induced obesity SD rats via oral administration.

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04:43

Polysaccharides extracted from Keemun black tea has an observable prevention of liver damage induced by carbon tetrachloride in mice. "IndyWatch Feed Health"

PMID:  Food Chem Toxicol. 2013 Aug ;58:184-92. Epub 2013 Apr 24. PMID: 23623843 Abstract Title:  Protective effects of Keemun black tea polysaccharides on acute carbon tetrachloride-caused oxidative hepatotoxicity in mice. Abstract:  This study was designed to investigate chemical characterization of the water-soluble polysaccharides extracted from Keemun black tea (KBTP), and their antioxidant and hepatoprotective effects against CCl4-induced oxidative damage in mice. HPLC analysis revealed that KBTP is the typical acidic heteropolysaccharides and consisted of nine monosaccharides. Furthermore, KBTP showed highly ferric-reducing antioxidant power and scavenging effects against DPPH, OH and O2(-) in vitro. Administration of KBTP (200, 400 and 800 mg/kg bw) in mice ahead of CCl4 injection could observably antagonize the CCl4-induced increases in serum ALT, AST, TG and TC, and the hepatic MDA and 8-iso-PGF2a levels, respectively. Mice with KBTP pretreatment displayed a better profile of hepatosomatic index and the improved GSH and SOD activities in comparison with CCl4-intoxicated mice. These biochemical results were further supported with liver histopathological assessment, revealing that KBTP has an observable prevention of liver damage induced by CCl4 in mice.

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04:29

The inhibitory effects of Keemun black tea on -amylase and -glucosidase were positively correlated to tea grades. "IndyWatch Feed Health"

PMID:  Food Chem. 2018 Apr 25 ;246:74-81. Epub 2017 Nov 8. PMID: 29291881 Abstract Title:  An emerging strategy for evaluating the grades of Keemun black tea by combinatory liquid chromatography-Orbitrap mass spectrometry-based untargeted metabolomics and inhibition effects on-glucosidase and -amylase. Abstract:  Quantitative analysis and untargeted liquid chromatography mass spectrum (LC-MS) based metabolomics of different grades of Keemun black tea (KBT) were conducted. Quantitative analysis did not show tight correlation between tea grades and contents of polyphenols, but untargeted metabolomics analysis revealed that high-grades KBT were distinguished from the low-grades. S-plot and Variable Importance (VIP) analysis gave 28 marker compounds responsible for the discrimination of different grades of KBT. The inhibitory effects of KBT on-amylase and -glucosidase were positively correlated to tea grades, and the correlation coefficient between each marker compound and inhibitory rate were calculated. Thirteen compounds were positively related to the anti-glycemic activity, and theasinensin A, afzelechin gallate and kaempferol-glucoside were confirmed as grade-related bioactive marker compounds by chemical and bioassay in effective fractions. This study suggested that combinatory metabolomics and bioactivities assay provided a new strategy for the classification of tea grades.

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04:23

28days of polyphenol supplementation modulates the acute JNK, BAD, and Bcl2 response to heavy resistance exercise. "IndyWatch Feed Health"

PMID:  Physiol Rep. 2018 Jan ;6(2). PMID: 29380956 Abstract Title:  Polyphenol supplementation alters intramuscular apoptotic signaling following acute resistance exercise. Abstract:  The purpose of this study was to examine the effects of 28-days of supplementation with an aqueous proprietary polyphenol blend (PPB) sourced from Camellia sinensis on intramuscular apoptotic signaling following an acute lower-body resistance exercise protocol and subsequent recovery. Untrained males (n = 38, 21.8  2.7 years, 173.4  7.9 cm, 77.6  14.6 kg) were randomized to PPB (n = 14), placebo (PL; n = 14) or control (CON; n = 10). Participants completed a lower-body resistance exercise protocol comprised of the squat, leg press, and leg extension exercises. Skeletal muscle microbiopsies were obtained from the vastus lateralis preexercise (PRE), 1-h (1HR), 5-h (5HR), and 48-h (48HR) post-resistance exercise. Apoptotic signaling pathways were quantified using multiplex signaling assay kits to quantify total proteins (Caspase 3, 8, 9) and markers of phosphorylation status (JNK, FADD, p53, BAD, Bcl-2). Changes in markers of muscle damage and intramuscular signaling were analyzed via separate repeated measures analysis of variance (ANOVA). Change in Bcl-2 phosphorylation at 1H was significantly greater in PL compared to CON (P = 0.001). BAD phosphorylation was significantly elevated at 5H in PL compared to PPB (P = 0.015) and CON (P = 0.006). The change in JNK phosphorylation was significantly greater in PPB (P = 0.009), and PL (P = 0.017) compared to CON at 1H, while the change for PL was elevated compared to CON at 5H (P = 0.002). A main effectwas observed (P 

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04:11

Polyphenols from green tea, oolong tea and black tea may modulate the intestinal flora and generate short chain fatty acids. "IndyWatch Feed Health"

PMID:  J Food Sci Technol. 2018 Jan ;55(1):399-407. Epub 2017 Dec 2. PMID: 29358833 Abstract Title:  The modulatory effect of polyphenols from green tea, oolong tea and black tea on human intestinal microbiota in vitro. Abstract:  In the present study, polyphenols from green tea (GTP), oolong tea (OTP) and black tea (BTP) were prepared by extraction with hot water and polyamide column chromatography. In antioxidant assay in vitro, each tea polyphenols exhibited potential activity; the intestinal absorption of GTP, OTP and BTP was investigated individually by Caco-2 transwell system, and each sample was poorly transported, illustrating a low transport rate for tea polyphenols through cell monolayers. The effects of GTP, OTP and BTP on human intestinal microbiota were also evaluated, and each sample induced the proliferation of certain beneficial bacteria and inhibited-and. Moreover, the short-chain fatty acids (SCFA) produced in cultures with tea polyphenols were relatively higher. Together, these results suggested GTP, OTP and BTP may modulate the intestinal flora and generate SCFA, and contribute to the improvements of human health.

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03:52

Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29384173 Abstract Title:  Comparative studies on the hypolipidemic, antioxidant and hepatoprotective activities of catechin-enriched green and oolong tea in a double-blind clinical trial. Abstract:  This study aimed to compare the beneficial effect of catechin-enriched green tea and oolong tea on mildly hypercholesterolemic subjects. Sixty mildly hypercholesterolemic subjects (180-220 mg dL) were enrolled and divided into three groups as catechin-enriched green tea (CEGT), catechin-enriched oolong tea (CEOT) or placebo. The subjects were instructed to drink 2 300 mL of CEGT (780.6 mg of catechin), CEOT (640.4 mg of catechin) or placebo beverage for 12 weeks. Drinking CEGT and CEOT significantly decreased (p

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03:49

Video: Fake News, Treason, Sedition, and the Deep State "IndyWatch Feed Health"

Sarah Corriher explores how the media and the deep state are working in tandem to undermine America's Republic, and to cause President Trump to lose his mainstream support through a campaign of violence and sabotage of the financial markets.

You may watch this on YouTube if there are any problems watching the video at this site. It can also be viewed at Spkout.

03:35

Aged oolong tea reduces high-fat diet-induced fat accumulation and dyslipidemia. "IndyWatch Feed Health"

PMID:  Nutrients. 2018 Feb 8 ;10(2). Epub 2018 Feb 8. PMID: 29419789 Abstract Title:  Aged Oolong Tea Reduces High-Fat Diet-Induced Fat Accumulation and Dyslipidemia by Regulating the AMPK/ACC Signaling Pathway. Abstract:  While oolong tea (OT) has been shown to induce weight loss and reduce fat accumulation, the mechanisms remain poorly defined, especially for aged OT. In this study, five groups of mice (= 9/group) were used including a normal diet with vehicle treatment, and a high-fat diet (HFD) with vehicle or the water extracts from aged OTs (EAOTs, three different storage years) by oral gavage at 1000 mg/kgBW for 6 weeks. Body weight, fat accumulation, and serum biochemical parameters were used to evaluate obesity. The morphology of hepatocytes and adipocytes was analyzed by being stained with hematoxylin and eosin. The levels of p-AMPK, p-ACC (and non-phosphorylated versions), CPT-1 and FAS were determined by Western blotting and immunohistochemistry. EAOTs decreased HFD-induced body weight, fat accumulation, serum levels of triglyceride, total cholesterol, and low-density lipoprotein cholesterol, while enhancing the serum high-density lipoprotein cholesterol level. At the same time, EAOTs clearly alleviated fatty liver and reduced the size of adipocytes in the epididymal fat, especially in the 2006 group. Most importantly, EAOTs increased the phosphorylation of AMPK and ACC, and up-regulated the expression of CPT-1 but down-regulated the expression of fatty acid synthase, TNF- and iNOS. Thus, EAOTs may inhibit obesity by up-regulating energy expenditure and fatty acid oxidation while inhibiting fatty acid synthesis and inflammation.

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03:33

Oral health expert Robin Whyman slams claims made by fluoride critic Paul Connett "IndyWatch Feed Health"

DHB clinical director for oral health Dr Robin Whyman says evidence shows fluoride can help reduce dental decay. Photo / File

DHB clinical director for oral health Dr Robin Whyman says evidence shows fluoride can help reduce dental decay. Photo / File

Fluoridating drinking water is about protecting the health interests of the wider population, a dental expert says.

This comes in response to a Fluoride Free meeting held on Wednesday, where prominent critic Dr Paul Connett told a 100-person audience about water fluoridation and the harm he argued it posed to health and the environment.

However, Hawkes Bay District Health Board clinical director for oral health Dr Robin Whyman said the board supported fluoridation as evidence showed its effect on reducing dental decay, particularly in children.

We think its good for our community, and we think it has a positive health benefit which will reduce peoples need for treatment and reduce cost both to the DHB and to peoples pockets.

Their position was consistent with that of the Ministry of Health, and other DHBs around the country. It was based on research which had been repeatedly backed up in both national and international studies, he said.

The Wednesday meeting was part of a New Zealand speaking tour featuring Dr Connett, a retired professor of environmental chemistry and toxicology at St Lawrence University, as the guest of Fluoride Free NZ.

His presentation touched on a number of ar...

03:08

Fermented oolong tea high in gallic acid as an effective dietary intervention strategy for tobacco-associated cancers. "IndyWatch Feed Health"

PMID:  Oncotarget. 2018 Jan 2 ;9(1):361-374. Epub 2017 Dec 7. PMID: 29416619 Abstract Title:  The inhibitory activity of gallic acid against DNA methylation: application of gallic acid on epigenetic therapy of human cancers. Abstract:  Epigenome aberrations have been observed in tobacco-associated human malignancies. (-)-epigallocatechin-3-gallate (EGCG) has been proven to modulate gene expression by targeting DNA methyltransferases (DNMTs) through a proposed mechanism involving the gallate moiety of EGCG. We show that gallic acid (GA) changes the methylome of lung cancer and pre-malignant oral cell lines and markedly reduces both nuclear and cytoplasmic DNMT1 and DNMT3B within 1 week. GA exhibits stronger cytotoxicity against the lung cancer cell line H1299 than EGCG. We found that GA reactivates the growth arrest and DNA damage-inducible 45 (GADD45) signaling pathway may through the demethylation of CCNE2 and CCNB1 in H1299 cells. To improve the epigenetic anti-cancer activities of oolong tea, we identified a fungus,which can efficiently increase the GA content in oolong tea via a 2-week fermentation process. The fungus dramatically increased GA up to 44.8 fold in the post-fermentation oolong tea extract (PFOTE), resulting in enhanced demethylation effects and a significant reduction in the nuclear abundances of DNMT1, DNMT3A, and DNMT3B in lung cancer cell lines. PFOTE also showed stronger anti-proliferation activities than oolong tea extract (OTE) and increased sensitivity to cisplatin in H1299 cells. In summary, we demonstrate the potent inhibitory effects of GA on the activities of DNMTs and provide a strong scientific foundation for the use of specialized fermented oolong tea high in GA as an effective dietary intervention strategy for tobacco-associated cancers.

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02:34

Florida School Shooting - and the State of American Education "IndyWatch Feed Health"

This is one of the times I wish with all my heart Dan Olmsted was alive to help guide this conversation. On Wednesday, a 19 year old kid shot and killed 17 students and faculty at a Florida high school....

02:23

Interested In Muscle? Eat Whole Eggs Rather Than Egg Whites "IndyWatch Feed Health"

Egg yolks also contain over 80 percent of the overall vitamins and minerals that can be found within the egg as a whole. The yolk also contains enzymes which help the body absorb the protein in the white. People who consume protein from whole eggs or from egg whites after engaging in exercise differ dramatically in how their muscles build protein, a process called protein synthesis, during the post-workout period, researchers report in a new study.

02:16

EGCG may potentially inhibit aging-induced cardiac hypertrophy, fibrosis, and apoptosis, thereby preserving cardiac function. "IndyWatch Feed Health"

PMID:  J Cardiovasc Pharmacol. 2018 Feb ;71(2):65-75. PMID: 29419571 Abstract Title:  Ameliorative Effect of Epigallocatechin Gallate on Cardiac Hypertrophy and Fibrosis in Aged Rats. Abstract:  The objective of the present study is to evaluate the effect of epigallocatechin gallate (EGCG) on aging-mediated cardiac hypertrophy, fibrosis, and apoptosis. The Wistar albino rats were divided into 4 groups (n = 18). Group I: young (3 months), group II: aged (24-26 months), group III: aged + EGCG (200 mg/kg for 30 days), and group IV: young + EGCG. At the end of 30 days, EGCG administration to the aged animals showed significant (P

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02:03

EGCG could potentially serve as an additional therapeutic intervention in the arsenal against obesity. "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Feb 9. Epub 2018 Feb 9. PMID: 29423494 Abstract Title:  EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition. Abstract:  As a major nutraceutical component of green tea (-)-epigallocatechin-3-gallate (EGCG) has attracted interest from scientists due to its well-documented antioxidant and antiobesity bioactivities. In the current study, we aimed to investigate the protective effect of EGCG on metabolic misalignment and in balancing the redox status in mice liver and HepG2 cells under insulin resistance condition. Our results indicated that EGCG accelerates the glucose uptake and evokes IRS-1/Akt/GLUT2 signaling pathway via dampening the expression of protein tyrosine phosphatase 1B (PTP1B). Consistently, ectopic expression of PTP1B by Ad-PTP1B substantially impaired EGCG-elicited IRS-1/Akt/GLUT2 signaling pathway. Moreover, EGCG co-treatment stimulated nuclear translocation of Nrf2 by provoking P13K/AKT signaling pathway and thus modulated the downstream expressions of antioxidant enzymes such as HO-1 and NQO-1 in HepG2 cells. Furthermore, knockdown Nrf2 by small interfering RNA (siRNA) notably enhanced the expression of PTP1B and blunt EGCG-stimulated glucose uptake. Consistent with these results, in vivo study revealed that EGCG supplement significantly ameliorated high-fat and high-fructose diet (HFFD)-triggered insulin resistance and oxidative stress by up-regulating the IRS-1/AKT and Keap1/Nrf2 transcriptional pathways. Administration of an appropriate chemopreventive agent, such as EGCG, could potentially serve as an additional therapeutic intervention in the arsenal against obesity.

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01:50

EGCG could be a novel treatment of neuro-inflammation and neurodegenerative diseases. "IndyWatch Feed Health"

PMID:  Mol Neurobiol. 2018 Feb 9. Epub 2018 Feb 9. PMID: 29427085 Abstract Title:  Regulatory Effects of Neuroinflammatory Responses Through Brain-Derived Neurotrophic Factor Signaling in Microglial Cells. Abstract:  Inhibition of microglial over-activation is an important strategy to counter balance neurodegenerative progression. We previously demonstrated that the adenosine monophosphate-activated protein kinase (AMPK) may be a therapeutic target in mediating anti-neuroinflammatory responses in microglia. Brain-derived neurotrophic factor (BDNF) is one of the major neurotrophic factors produced by astrocytes to maintain the development and survival of neurons in the brain, and have recently been shown to modulate homeostasis of neuroinflammation. Therefore, the present study focused on BDNF-mediated neuroinflammatory responses and may provide an endogenous regulation of neuroinflammation. Among the tested neuroinflammation, epigallocatechin gallate (EGCG) and minocycline exerted BDNF upregulation to inhibit COX-2 and proinflammatory mediator expressions. Furthermore, both EGCG and minocycline upregulated BDNF expression in microglia through AMPK signaling. In addition, minocycline and EGCG also increased expressions of erythropoietin (EPO) and sonic hedgehog (Shh). In the endogenous modulation of neuroinflammation, astrocyte-conditioned medium (AgCM) also decreased the expression of COX-2 and upregulated BDNF expression in microglia. The anti-inflammatory effects of BDNF were mediated through EPO/Shh in microglia. Our results indicated that the BDNF-EPO-Shh novel-signaling pathway underlies the regulation of inflammatory responses and may be regarded as a potential therapeutic target in neurodegenerative diseases. This study also reveals a better understanding of an endogenous crosstalk between astrocytes and microglia to regulate anti-inflammatory actions, which could provide a novel strategy for the treatment of neuroinflammation and neurodegenerative diseases.

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01:35

EGCG inhibited self-renewal and expression of pluripotency-maintaining transcription factors in human cancer stem cells. "IndyWatch Feed Health"

PMID:  Mol Cells. 2018 Jan 31. Epub 2018 Jan 31. PMID: 29429153 Abstract Title:  Cancer Prevention with Green Tea and Its Principal Constituent, EGCG: from Early Investigations to Current Focus on Human Cancer Stem Cells. Abstract:  Cancer preventive activities of green tea and its main constituent, (-)-epigallocatechin gallate (EGCG) have been extensively studied by scientists all over the world. Since 1983, we have studied the cancer chemopreventive effects of EGCG as well as green tea extract and underlying molecular mechanisms. The first part of this review summarizes groundbreaking topics with EGCG and green tea extract: 1) Delayed cancer onset as revealed by a 10-year prospective cohort study, 2) Prevention of colorectal adenoma recurrence by a double-blind randomized clinical phase II trial, 3) Inhibition of metastasis of B16 melanoma cells to the lungs of mice, 4) Increase in the average value of Young's moduli, i.e., cell stiffness, for human lung cancer cell lines and inhibition of cell motility and 5) Synergistic enhancement of anticancer activity against human cancer cell lines with the combination of EGCG and anticancer compounds. In the second part, we became interested in cancer stem cells (CSCs). 1) Cancer stem cells in mouse skin carcinogenesis by way of introduction, after which we discuss two subjects from our review on human CSCs reported by other investigators gathered from a search of PubMed, 2) Expression of stemness markers of human CSCs compared with their parental cells, and 3) EGCG decreases or increases the expression of mRNA and protein in human CSCs. On this point, EGCG inhibited self-renewal and expression of pluripotency-maintaining transcription factors in human CSCs. Human CSCs are thus a target for cancer prevention and treatment with EGCG and green tea catechins.

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01:21

Inhibitory effect of the green tea molecule EGCG against dengue virus infection. "IndyWatch Feed Health"

PMID:  Arch Virol. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29429035 Abstract Title:  Inhibitory effect of the green tea molecule EGCG against dengue virus infection. Abstract:  Dengue virus (DENV) infection is a major public health problem worldwide; however, specific antiviral drugs against it are not available. Hence, identifying effective antiviral agents for the prevention of DENV infection is important. In this study, we showed that the reportedly highly biologically active green-tea component epigallocatechin gallate (EGCG) inhibited dengue virus infection regardless of infecting serotype, but no or minimal inhibition was observed with other flaviviruses, including Japanese encephalitis virus, yellow fever virus, and Zika virus. EGCG exerted its antiviral effect mainly at the early stage of infection, probably by interacting directly with virions to prevent virus infection. Our results suggest that EGCG specifically targets DENV and might be used as a lead structure to develop an antiviral drug for use against the virus.

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01:07

EGCG exerts a neuroprotective effect on experimental autoimmune thyroiditis. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2018 Jan ;15(1):1087-1092. Epub 2017 Nov 14. PMID: 29434699 Abstract Title:  Neuroprotective effect of (-)-epigallocatechin-3-gallate on autoimmune thyroiditis in a rat model by an anti-inflammation effect, anti-apoptosis and inhibition of TRAIL signaling pathway. Abstract:  (-)-Epigallocatechin-3-gallate (EGCG) is a polyphenol monomer compound extracted and separated from green tea, and is a key catechin in green tea. Recent research has identified that EGCG is equipped with important biological activities, including antitumor, antioxidant, anti-inflammation, blood fat reduction and radiation protection abilities. In the current study, it was investigated whether EGCG exerts a neuroprotective effect on AIT and examined the possible underlying mechanism. The present study sought to establish an experimental autoimmune thyroiditis (AIT) rat model and to investigate the neuroprotective effect of EGCG in this model. EGCG was demonstrated to inhibit urinary iodine values and thyroid pathological features in AIT model rats. Treatment with EGCG significantly reduced interleukin-1, interferon- (INF-) and tumor necrosis factor- (TNF-) levels in the AIT rats through suppression of nuclear factor-B (NF-B) pathway. In addition, pretreatment with EGCG significantly increased B-cell lymphoma-2 protein expression, and suppressed caspase-3 activity and TNF--related apoptosis-inducing ligand (TRAIL) protein expression levels in the AIT model rats. In conclusion, these results suggested that the neuroprotective effect of EGCG protects against AIT through its anti-inflammatory ability, anti-apoptosis and TRAIL signaling pathway in model rats, and it may be used asa therapeutic agent against AIT caused by inflammation.

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00:30

Hempseed peptides exert hypocholesterolemic effects with a statin-like mechanism. "IndyWatch Feed Health"

PMID:  J Agric Food Chem. 2017 Oct 11 ;65(40):8829-8838. Epub 2017 Oct 2. PMID: 28931275 Abstract Title:  Hempseed Peptides Exert Hypocholesterolemic Effects with a Statin-Like Mechanism. Abstract:  This study had the objective of preparing a hempseed protein hydrolysate and investigating its hypocholesterolemic properties. The hydrolysate was prepared treating a total protein extract with pepsin. Nano HPLC-ESI-MS/MS analysis permitted identifying in total 90 peptides belonging to 33 proteins. In the range 0.1-1.0 mg/mL, it inhibited the catalytic activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCoAR) in a dose-dependent manner. HepG2 cells were treated with 0.25, 0.5, and 1.0 mg/mL of the hydrolysate. Immunoblotting detection showed increments in the protein levels of regulatory element binding proteins 2 (SREBP2), low-density lipoprotein receptor (LDLR), and HMGCoAR. However, the parallel activation of the phospho-5'-adenosine monophosphate-activated protein kinase (AMPK) pathway, produced an inactivation of HMGCoAR by phosphorylation. The functional ability of HepG2 cells to uptake extracellular LDL was raised by 50.5 2.7%, 221.5 1.6%, and 109 3.5%, respectively, versus the control at 0.25, 0.5, and 1.0 mg/mL concentrations. Finally, also a raise of the protein level of proprotein convertase subtilisin/kexintype 9 was observed. All of these data suggest that the mechanism of action has some similarity with that of statins.

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00:23

The anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA. "IndyWatch Feed Health"

PMID:  Cannabis Cannabinoid Res. 2017 ;2(1):167-182. Epub 2017 Jul 1. PMID: 29082314 Abstract Title:  Anti-Inflammatory Activity in Colon Models Is Derived from9-Tetrahydrocannabinolic Acid That Interacts with Additional Compounds inExtracts. Abstract:  Inflammatory bowel diseases (IBDs) include Crohn's disease, and ulcerative colitis.preparations have beneficial effects for IBD patients. However,extracts contain hundreds of compounds. Although there is much knowledge of the activity of different cannabinoids and their receptor agonists or antagonists, the cytotoxic and anti-inflammatory activity of wholeextracts has never been characterized in detail withandcolon models.The anti-inflammatory activity ofextracts was studied on three lines of epithelial cells and on colon tissue.flowers were extracted with ethanol, enzyme-linked immunosorbent assay was used to determine the level of interleukin-8 in colon cells and tissue biopsies, chemical analysis was performed using high-performance liquid chromatography, mass spectrometry and nuclear magnetic resonance and gene expression was determined by quantitative real-time PCR.The anti-inflammatory activity of Cannabis extracts derives from D9-tetrahydrocannabinolic acid (THCA) present in fraction 7 (F7) of the extract. However, all fractions ofat a certain combination of concentrations have a significant increased cytotoxic activity. GPR55 receptor antagonist significantly reduces the anti-inflammatory activity of F7, whereas cannabinoid type 2 receptor antagonist significantly increases HCT116 cell proliferation. Also, cannabidiol (CBD) shows dose dependent cytotoxic activity, whereas anti-inflammatory activity was found only for the low concentration of CBD, and in a bell-shaped rather than dose-dependent manner. Activity of the extract and active fraction was verified on colon tissues taken from IBD patients, and was shown to suppress cyclooxygenase-2 () and metalloproteinase-9 () gene expression in both cell culture and colon tissue.It is suggested that the anti-inflammatory activity of Cannabis extracts on colon epithelial cells derives from a fraction of the extract that contains THCA, and is mediated, at least partially, via GPR55 receptor. The cytotoxic activity of theextract was increased by combining all fractions at a certain combination of concentrations and was partially affected by CB2 receptor antagonist that increased cell proliferation. It is suggested that in a nonpsychoactive treatment for IBD, THCA should be used rather than CBD.

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00:00

An extract of fructus cannabis ameliorates learning and memory impairment induced by d-galactose. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2017 ;2017:4757520. Epub 2017 Oct 19. PMID: 29234402 Abstract Title:  Extract of Fructus Cannabis Ameliorates Learning and Memory Impairment Induced by D-Galactose in an Aging Rats Model. Abstract:  Hempseed (L.) has been used as a health food and folk medicine in China for centuries. In the present study, we sought to define the underlying mechanism by which the extract of Fructus Cannabis (EFC) protects against memory impairment induced by D-galactose in rats. To accelerate aging and induce memory impairment in rats, D-galactose (400mg/kg) was injected intraperitoneally once daily for 14 weeks. EFC (200 and 400mg/kg) was simultaneously administered intragastrically once daily in an attempt to slow the aging process. We found that EFC significantly increased the activity of superoxide dismutase, while lowering levels of malondialdehyde in the hippocampus. Moreover, EFC dramatically elevated the organ indices of some organs, including the heart, the liver, the thymus, and the spleen. In addition, EFC improved the behavioral performance of rats treated with D-galactose in the Morris water maze. Furthermore, EFC inhibited the activation of astrocytes and remarkably attenuated phosphorylated tau and suppressed the expression of presenilin 1 in the brain of D-galactose-treated rats. These findings suggested that EFC exhibits beneficial effects on the cognition of aging rats probably by enhancing antioxidant capacityand anti-neuroinflammation, improving immune function, and modulating tau phosphorylation and presenilin expression.

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Thursday, 15 February

23:31

C. sativa decreased tau and stathmin gene expression and cancer metastasis. "IndyWatch Feed Health"

PMID:  Iran J Basic Med Sci. 2017 Oct ;20(10):1178-1181. PMID: 29147495 Abstract Title:  Standardizedextract attenuates tau and stathmin gene expression in the melanoma cell line. Abstract:  Objectives: Metastasis is the main cause of death in patients with melanoma. Cannabis-based medicines are effective adjunctive drugs in cancer patients. Tau and Stathmin proteins are the key proteins in cancer metastasis. Here we have investigated the effect of a standardizedextract on cell migration and Tau and Stathmin gene expression in the melanoma cell line.Materials and Methods: In the treatment group, melanoma (B1617) was treated 48 hr with various concentrations of standardizedextract. Cells with no treatment were considered as the control group, then study was followed by Quantitative RT-Real Time PCR assay. Relative gene expression was calculated by thect method. Migration assay was used to evaluate cancer metastasis.Results: Tau and stathmin gene expression was significantly decreased compared to the control group. Cell migration was also significantly reduced compared to controls.Conclusion: decreased tau and stathmin gene expression and cancer metastasis. The results may have some clinical relevance for the use of cannabis-based medicines in patients with metastatic melanoma.

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23:17

Extracts of Cannabis with high content of non-psychotropic cannabinoids significantly inhibit aldose reductase activity. "IndyWatch Feed Health"

PMID:  Fitoterapia. 2018 Feb 7. Epub 2018 Feb 7. PMID: 29427593 Abstract Title:  Inhibition of aldose reductase activity by Cannabis sativa chemotypes extracts with high content of cannabidiol or cannabigerol. Abstract:  Aldose reductase (ALR2) is a key enzyme involved in diabetic complications and the search for new aldose reductase inhibitors (ARIs) is currently very important. The synthetic ARIs are often associated with deleterious side effects and medicinal and edible plants, containing compounds with aldose reductase inhibitory activity, could be useful for prevention and therapy of diabetic complications. Non-psychotropic phytocannabinoids exert multiple pharmacological effects with therapeutic potential in many diseases such as inflammation, cancer, diabetes. Here, we have investigated the inhibitory effects of extracts and their fractions from two Cannabis sativa L. chemotypes with high content of cannabidiol (CBD)/cannabidiolic acid (CBDA) and cannabigerol (CBG)/cannabigerolic acid (CBGA), respectively, on human recombinant and pig kidney aldose reductase activity in vitro. A molecular docking study was performed to evaluate the interaction of these cannabinoids with the active site of ALR2 compared to known ARIs. The extracts showed significant dose-dependent aldose reductase inhibitory activity (>70%) and higher than fractions. The inhibitory activity of the fractions was greater for acidic cannabinoid-rich fractions. Comparative molecular docking results have shown a higher stability of the ALR2-cannabinoid acids complex than the other inhibitors. The extracts of Cannabis with high content of non-psychotropic cannabinoids CBD/CBDA or CBG/CBGA significantly inhibit aldose reductase activity. These results may have some relevance for the possible use of C. sativa chemotypes based preparations as aldose reductase inhibitors.

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22:49

These findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects. "IndyWatch Feed Health"

PMID:  Epilepsy Behav. 2018 Feb 8. Epub 2018 Feb 8. PMID: 29429908 Abstract Title:  Efficacy of artisanal preparations of cannabidiol for the treatment of epilepsy: Practical experiences in a tertiary medical center. Abstract:  Medically refractory epilepsy continues to be a challenge worldwide, and despite an increasing number of medical therapies, approximately 1 in 3 patients continues to have seizures. Cannabidiol (CBD), one of many constituents of the Cannabis sativa or marijuana plant, has received renewed interest in the treatment of epilepsy. While highly purified CBD awaits Food and Drug Administration (FDA) approval, artisanal formulations of CBD are readily available and are seeing increased use in our patient population. Although randomized controlled trials of CBD are ongoing and promising, data regarding artisanal formulations of CBD are minimal and largely anecdotal. Here, we report a retrospective study to define the efficacy of artisanal CBD preparations in children with epilepsy. Given the known interaction between CBD and clobazam, we also conducted a subgroup comparison to determine if clobazam use was related to any beneficial effects of CBD. Additionally, we compared response rates with CBD and with clobazam alone within an overlapping patient cohort. A pediatric cohort with epilepsy of 108 patients was identified through a medical record search for patients using CBD oil. The addition of CBD resulted in 39% of patients having a>50% reduction in seizures, with 10% becoming seizure-free. The responder rate for clobazam was similar. No patients achieved CBD monotherapy, although the weaning of other antiepileptic drugs (AEDs) became possible in 22% of patients. A comparable proportion had AED additions during CBD therapy. With concomitant use of clobazam, 44% of patients had a 50% reduction in seizures upon addition of CBD compared with 33% in the population not taking clobazam; this difference was not statistically significant. The most common reported side effect of CBD was sedation in less than 4% of patients, all of whom were also taking clobazam. Increased alertness and improved verbal interactions were reported in 14% of patients in the CBD group and 8% of patients in the CBD and clobazam group. Benefits were more marked in the CBD alone group, in contrast to the CBD and clobazam group, but this difference was not statistically significant. In summary, these findings support efficacy of artisanal CBD preparations in seizure reduction with few significant side effects. The response to CBD was independent of concurrent clobazam use, although clobazam may contribute to the sedation seen with concurrent CBD use.

...

22:26

This data further supports the evaluation of CBD and CBD-rich extracts for the potential treatment of endometrial cancer. "IndyWatch Feed Health"

PMID:  J Physiol Biochem. 2018 Feb 13. Epub 2018 Feb 13. PMID: 29441458 Abstract Title:  Cannabinoid-induced cell death in endometrial cancer cells: involvement of TRPV1 receptors in apoptosis. Abstract:  Among a variety of phytocannabinoids,-tetrahydrocannabinol (THC) and cannabidiol (CBD) are the most promising therapeutic compounds. Besides the well-known palliative effects in cancer patients, cannabinoids have been shown to inhibit in vitro growth of tumor cells. Likewise, the major endocannabinoids (eCBs), anandamide (AEA) and 2-arachidonoylglycerol (2-AG), induce tumor cell death. The purpose of the present study was to characterize cannabinoid elements and evaluate the effect of cannabinoids in endometrial cancer cell viability. The presence of cannabinoid receptors, transient receptor potential vanilloid 1 (TRPV1), and endocannabinoid-metabolizing enzymes were determined by qRT-PCR and Western blot. We also examined the effects and the underlying mechanisms induced by eCBs and phytocannabinoids in endometrial cancer cell viability. Besides TRPV1, both EC cell lines express all the constituents of the endocannabinoid system. We observed that at concentrations higher than 5 M, eCBs and CBD induced a significant reduction in cell viability in both Ishikawa and Hec50co cells, whereas THC did not cause any effect. In Ishikawa cells, contrary to Hec50co, treatment with AEA and CBD resulted in an increase in the levels of activated caspase -3/-7, in cleaved PARP, and inreactive oxygen species generation, confirming that the reduction in cell viability observed in the MTT assay was caused by the activation of the apoptotic pathway. Finally, these effects were dependent on TRPV1 activation and intracellular calcium levels. These data indicate that cannabinoids modulate endometrial cancer cell death. Selective targeting of TPRV1 by AEA, CBD, or other stable analogues may be an attractive research area for the treatment of estrogen-dependent endometrial carcinoma. Our data further support the evaluation of CBD and CBD-rich extracts for the potential treatment of endometrial cancer, particularly, that has become non-responsive to common therapies.

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22:04

Dog Almost Dies From Human Hair Dye What Does That Tell You? "IndyWatch Feed Health"

Dog and abstract background, Beautiful color spots structure

by Dr. Mercola

Just because a product is sold over-the-counter in stores, it does not mean its safe. There are nearly 13,000 chemicals found in personal care products sold in the U.S., and only 10 percent have been tested for safety. To compound the problem, the U.S. Food and Drug Administration (FDA) has the ability to regulate personal care products only after a product has demonstrated harm. [1]

Additionally, the FDA has handed over the responsibility of ensuring public safety to manufacturers whose financial health is dependent upon selling their products, and those manufacturers are not legally responsible to report adverse effects to the FDA. [2] What this means is that while you may be health conscious, body lotions, deodorants, soaps or shampoos you use may have harmful chemicals even if the product is labeled nontoxic and safe.

The average American woman uses 12 personal care products daily, containing an average of 168 chemicals. [3] Men are exposed to nearly half that amount, but teens, who average 17 personal care products a day, are exposed to an even greater number.

This everyday exposure to toxic chemicals has been associated with a number of health conditions, including early ovarian dysfunction and menopause that may lead to early development of heart disease and osteoporosis. While personal care products may be hazardous for you, using these products on your pet may have lethal consequences.

Violet Demonstrates Dangers of Hair Dye

A 5-pound Maltese mixed dog named Violet recently brought to light the extreme danger owners put their dogs in when attempting to dye their fur using hair dye meant for people. [4] The dog was brought to the Pinellas County Animal Services to be treated for her injuries, which included badly burned skin. Once at the facility, the st...

22:02

Study: Antioxidants in Virgin Coconut Oil Counteract Environmental Pollutants and Improve Cardiovascular Health "IndyWatch Feed Health"

Stethoscope and heart

by Brian Shilhavy
Editor, Health Impact News

A new study published in Avicenna Journal of Phytomedicine sheds further light on how coconut oil, virgin coconut oil in particular, enhances cardiovascular health, in direct contradiction to the U.S. government claims that coconut oil leads to heart disease.

As is to be expected, much of the research published in peer-reviewed journals showing that coconut oil enhances heart health in recent years has been conducted outside the U.S., in tropical cultures where coconuts grow. These countries are finding out for themselves that they have been misled by U.S. policy that condemns their native diets which includes coconuts and coconut oil. See:

War on Saturated Fats Has Harmed People in Poor Countries Who Shunned Traditional Fats Like Coconut Oil

How Africans have been fooled to think coconut oil and other traditional foods from their culture are unhealthy

Trust the Good Old Coconut and its Oil

This current study conducted in Nigeria looked at the pathogenic role of cadmium (Cd) and its exposure in the induction of dyslipidemia implicated in the development and increasing incidence of cardiovascular diseases, and explored whether polyphenolics isolated from virgin coconut oil (VCO) could prevent Cd-induced dyslipidemia.

Cadmium (Cd) is a widespread environmental and occupational pollutant that has emerged as a major cause of pathobiochemical events and damage in a number of organs. Cadmium concentration has increased in the biosphere through mining, smelting, agricultural and industrial activities (P...

21:14

NHRC issues notices to Cgarh Govt, Ministry of Drinking Water over high levels of fluoride "IndyWatch Feed Health"

New Delhi, Feb 15 The National Human Rights Commission (NHRC) on Thursday issued notices to the Chief Secretary, Government of Chhattisgarh and the Secretary, Union Ministry of Drinking Water and Sanitation, calling for the detailed reports over the increasing number of patients due to high levels of fluoride and arsenic in drinking water, within four weeks.

The Commission has taken suo motu cognizance of a media report that despite the joint efforts of the Centre and the Government of Chhattisgarh, the number of patients suffering from fluorosis and kidney diseases is increasing due to high level of arsenic and fluoride in drinking water in the state, an official statement said.

The number of total 1148 patients till August, 2016, has gone up now to 1170. The villages adjacent to the industrial areas have been reported to be worst affected. These include, among others, areas in Bastar, Raigarh, Bemetara districts.

According to the data released by the government, 55 people have died in Supebeda of Gariaband district. However, villagers claim that 103 deaths have happened due to the diseases caused by drinking contaminated water. About 225 people are suffering from kidney diseases, it said.

According to the media report, about one and an half year back, the Central Government had issued data relating to areas affected with arsenic and fluoride. At that time, the maximum affected areas were found in Rajasthan. Apart from Chhattisgarh, Bihar, West Bengal, Assam, Jharkhand, Punjab, Odisha, Karnataka and Telangana are also suffering from the same health hazard.

*Original article online at http://www.uniindia.com/nhrc-issues-notices-to-c-garh-govt-ministry-of-drinking-water-over-high-levels-of-fluoride/india/news/1139592.html

21:07

Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease. "IndyWatch Feed Health"

PMID:  Transl Psychiatry. 2018 Jan 31 ;8(1):32. Epub 2018 Jan 31. PMID: 29382825 Abstract Title:  Ultramicronized palmitoylethanolamide rescues learning and memory impairments in a triple transgenic mouse model of Alzheimer's disease by exerting anti-inflammatory and neuroprotective effects. Abstract:  In an aging society, Alzheimer's disease (AD) exerts an increasingly serious health and economic burden. Current treatments provide inadequate symptomatic relief as several distinct pathological processes are thought to underlie the decline of cognitive and neural function seen in AD. This suggests that the efficacy of treatment requires a multitargeted approach. In this context, palmitoylethanolamide (PEA) provides a novel potential adjunct therapy that can be incorporated into a multitargeted treatment strategy. We used young (6-month-old) and adult (12-month-old) 3Tg-AD mice that received ultramicronized PEA (um-PEA) for 3 months via a subcutaneous delivery system. Mice were tested with a range of cognitive and noncognitive tasks, scanned with magnetic resonance imaging/magnetic resonance spectroscopy (MRI/MRS), and neurochemical release was assessed by microdialysis. Potential neuropathological mechanisms were assessed postmortem by western blot, reverse transcription-polymerase chain reaction (RT-PCR), and immunofluorescence. Our data demonstrate that um-PEA improves learning and memory, and ameliorates both the depressive and anhedonia-like phenotype of 3Tg-AD mice. Moreover, it reduces A formation, the phosphorylation of tau proteins, and promotes neuronal survival in the CA1 subregion of the hippocampus. Finally, um-PEA normalizes astrocytic function, rebalances glutamatergic transmission, and restrains neuroinflammation. The efficacy of um-PEA is particularly potent in younger mice, suggesting its potential as an early treatment. These data demonstrate that um-PEA is a novel and effective promising treatment for AD with the potential to be integrated into a multitargeted treatment strategy in combination with other drugs. Um-PEAis already registered for human use. This, in combination with our data, suggests the potential to rapidly proceed to clinical use.

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20:15

Goodbye Organ Donation Scientists Generated Healthy Lung Tissue From Mans Own Stem Cells "IndyWatch Feed Health"

By Heather CallaghanEditor

Breaking news fantastic!

The research signifies that the revival of human organs has stepped out of the lab and into clinical application.

For the time being, research has seemingly ebbed from the use of embryonic stem cells. Not only for their controversy but also their expense, difficulty and inconsistent success rate. However, we have within ourselves regenerative stem cells that repair the body and go anywhere they are needed. So they do not have the complications of other cell or transplant therapies. Stem cell therapy is one of the more recent breakthroughs that not only may go down in history, but also has researchers holding the M-word on their tongues miracle. 

For most of history, lung disease was a death knell. In an exciting and positive news twist, a man now has a regenerated set of lungs and a new lease on life thanks to stem cell therapy.

China Daily reports:

Chinese researchers have regenerated human lung tissue in a patient using that patients own stem cells, the first time that has been achieved worldwide, said Zuo Wei, lead r...

20:04

Conflicts of Interest Mar FDA Pharmacy Committee "IndyWatch Feed Health"

Individualized and natural medications are under threat. Action Alert!

Millions of Americans rely on customized medicines made at compounding pharmacies, including bioidentical hormones like estriol. That access is threatened by an FDA advisory committee that is rife with conflicts of interest, including the pharmaceutical industry, which competes with compounding pharmacies.

For years now, weve been reporting on the FDAs Pharmacy Compounding Advisory Committee (PCAC). The committee plays an important role in advising the FDA on implementation of the Drug Quality and Security Act of 2013 (DQSA). Thus far PCACs main role has been to make recommendations regarding which substances should or should not be included on the Bulk Drug List as well as the Difficult to Compound list. When completed, these lists will dictate which medicines can continue to be made at compounding pharmaciesspecialized pharmacies that make customized, oftentimes natural medications to meet the needs of individual patients.

Unfortunately, the track record so far has been abysmal, with PCAC routinely following the FDAs lead and voting to exclude almost every natural medicine with which theyre presented.

A big part of the problem is PCACs composition. As weve pointed out before, the committee is a stacked deck against pharmacy compounding. Only one member of the committee is a compounder, and he cannot vote. Of the remaining eleven PCAC members, four are academics, three are government officials (one from FDA and two from the National Institutes of Health), and three are non-profit representatives.

Of particular concern is Pew Charitable Trusts representation on the committee. Pew presents itself as an independent, nonpartisan research and public policy organization with a longstanding focus on drug quality issues, including pharmaceutical compounding. Upon closer examination, though, it seems to us that Pew isnt so independent and may have aligned itself with the pharmaceutical industry.

On June 12, 2017, Pew...

20:02

Fraudulent Organics Certifier to be Reinstated: Does USDA Care? "IndyWatch Feed Health"

Organic certifier, banned in EU and Canada, to be reinstated by US. Action Alert!

Sources at the US Department of Agriculture (USDA) have told us that they are planning to recertify ETKO, a Turkish-based organic certifier. As weve reported previously, ETKO has been singled out by some countries, notably Canada and the European Union, for its fraudulent certifications. These countries have decertified the organizationmeaning that they no longer accept ETKO-certified products as organic.

The USDA has had problems with ETKO as far back as 2009, but instead of decertifying this company, it actually reached a settlement agreement with them in 2016. The firm has been under audit by USDA for about a year.

Millions of pounds of fake organic products from overseas have been flooding US markets and threatening domestic producers who follow the rules. One would think that the USDAs organic program would take the matter seriously and protect consumers from fraud. The agencys dealings with ETKO, however, paint a different picture.

Its time for the USDA to protect consumers, domestic farmers, and the integrity of the organic seal by holding fraudulent certifiers accountable.

Action Alert! Write to the USDA and tell them NOT to recertify ETKO. Please send your message immediately.

19:59

Will Your State Block Access to Natural Healthcare Choices or Supplements? "IndyWatch Feed Health"

New bills introduced throughout the US. Will you and your family be affected?  State-based action alerts!

Its the beginning of many states legislative sessions, and there are a number of bills being considered that could affect your access to naturopaths, nutritionists, and supplements, as well as vaccine choice. Check below to see if your state is one of them and click the link to take action!

Dietetics

ANH believes that the market for nutrition services should be open and transparent, where consumers can decide for themselves the level of education, experience, and the kind of training they prefer in a nutrition professional. Too often, particular trade associations, such as the Academy of Nutrition and Dietetics (AND), the trade association for Registered Dieticians, try to exclude other professionals from practicing and instead create a monopoly for one particular type of professional. In practice this often means that practitioners who dont ascribe to a narrow set of conventional practices are unable to compete. ANH supports state bills that allow nutrition professionals to practice to the full extent of their knowledge and training. Click on your state to take action below.

Oppose:

New York SB 2231 provides for licensure of dieticians and nutritionists but does not allow unlicensed practitioners to practice medical nutrition therapymeaning that unlicensed individuals could not provide consumers with information related to specific conditions, which we believe is overly restrictive and does not allow all professionals to practice to the full extent of their education and training.

Florida SB 758/HB 561 restricts who can provide diabetes self-management training to someone who is registered and is a certified diabetes educator from the American Association of Diabetes Educators (AADE). This unfairly restricts the market for diabetes education to those certified to the AADE. Patients should be afforded the choice to seek advice from the practitioner best suited to help them, and not have their choices arbitrarily limited by the state government. It is also not the governments role to deliver business to the AADE, and help them win a monopoly over the diabetes education field.

Support:

Florid...

19:34

FDA Back Channel Lets Pharma Turn Nutrients Into Drugs "IndyWatch Feed Health"

Supplements become drugs and you pay. Tell FDA- Not this time! Action Alert!

By failing to complete a key supplement policy, the FDA has provided a way for pharmaceutical companies to take natural compounds and turn them into costly drugs. The longer the agency delays, the greater the danger that more and more nutrients will be nabbed by pharmaceutical companies, forcing cheaper supplement forms from the market.

L-glutamine is the most recent example. Last year, the FDA announced the approval of a new drug for sickle cell disease called Endari. Endari is an oral powder comprised of L-glutamine, an important amino acid. The drug company, Emmaus Medical, Inc., says in its materials that an IND (investigational new drug) application for L-glutamine was originally filed on May 15, 1997. According to the FDAs website, there is no new dietary ingredient (NDI) notification for L-glutamine.

If Emmaus enforces its IND, the only way that L-glutamine supplements could survive is if the FDA decides to consider L-glutamine an old dietary ingredient (ODI) that does not require an NDI notification. In other words, a company would have to prove that L-glutamine was marketed in or as a dietary supplement before 1994.

This is a key point, and another tactic the FDA has used to benefit the pharmaceutical industry. Defining an ODI as a substance marketed in or as a supplement, rather than anything sold or in the food supply before 1994 as Congress intended, is an FDA invention. Fewer supplements will qualify as ODIs under FDAs definition, which means more nutrients...

18:39

How to Harvest Wild Pine Nuts "IndyWatch Feed Health"

Source: How to Harvest Wild Pine Nuts For more content like this visit REALfarmacy.com.

The majority of pine nuts you can purchase at a local store or online originate in China, are highly pasteurized, and cost a small fortune! Wouldnt it be so nice if you could pick your own and eat them as fresh as they get, and for free? Forget the saving money part for a minute. []

Source: How to Harvest Wild Pine Nuts Learn more at REALfarmacy.com - Healthy News and Information.

18:11

Can We End Active Shooter Events? "IndyWatch Feed Health"

 

Can we end active shooter events?

active shooters part of the New Normal?

active shooters part of the New Normal?

A mentally disturbed man entered a South Florida high school and killed at least 17 people with an AR-15 rifle. Nikolas Cruz was expelled from the school for erratic and violent behavior and was reported to have an obsession with guns. Social media posts were also thought to be disturbing. At present, at least a dozen people are still in the hospital, some in critical condition.

The recent shootings in diverse settings greet Americans with tragic news on a regular basis. Schools, churches, concerts, and other public venues are now fair game for those with bad intentions. Armed not only with weapons but with a blueprint from previous incidents, gunmen identify soft targets more and more easily and are more successful in achieving their goal of creating mass casualties.

Mass shootings are considered to be something that happens elsewhere, not your home town. This time, however, the attack at Marjory Stoneman Douglas High occurred just a few miles from our house. Theres no reason to believe your area is immune.

There is no place safe from the deranged, disgruntled, or politically-motivated. The number of vehicular attacks, bombings, and shootings indicate that these events have become part of the New Normal. Should we just get used to them?

You might think that the successes achieved of late by active shooters occur at random. The increase in the sheer number of casualties, however, reveal a strategy that is being refined, and to deadly effect.

The selection of soft targets is becoming a science, and is leading to higher numbers of deaths and injuries. In the South Florida school shooting, for example, th......

17:36

Doctor Warns: Getting the Flu Is Safer Than Getting the Flu Shot "IndyWatch Feed Health"

Source: Doctor Warns: Getting the Flu Is Safer Than Getting the Flu Shot For more content like this visit REALfarmacy.com.

By ETHAN HUFF Influenza season is upon us once again, and this year the mainstream media is going hog wild with reports about a deadly new strain of circulating wild flu thats said to be exceptionally virulent. But before you rush out to get a flu shot as protection, you might want to take a []

Source: Doctor Warns: Getting the Flu Is Safer Than Getting the Flu Shot Learn more at REALfarmacy.com - Healthy News and Information.

17:28

Did You Know? 63% of Americans Actively Avoid Soda Pop "IndyWatch Feed Health"

Source: Did You Know? 63% of Americans Actively Avoid Soda Pop For more content like this visit REALfarmacy.com.

By Dr. Mercola Americans are finally starting to realize the dangers of soda, with nearly two-thirds (63 percent) saying they actively try to avoid soda in their diet, a new Gallup poll revealed.1 This is a significant increase from 2002, when only 41 percent were trying to avoid soda, and a clear sign that, as []

Source: Did You Know? 63% of Americans Actively Avoid Soda Pop Learn more at REALfarmacy.com - Healthy News and Information.

17:23

Are We About to Enter a Golden Age of Health? "IndyWatch Feed Health"

Let me confess my bias right at the start By Kent Heckenlively, JD I believe the pharmaceutical companies are best described as a criminal cabal which have inflicted unbelievable suffering on humanity. However, Im not sure my cheerful approach will carry the day.  Which begs the question, how do we win? For several months I Continue reading Are We About to Enter a Golden Age of Health?

The post Are We About to Enter a Golden Age of Health? appeared first on BolenReport.

16:37

Watch: Woman Dragged Out of House Hearing For Listing Oil and Gas Contributions to Members "IndyWatch Feed Health"

woman dragged out of house hearing Oil and Gas Contributions

The people who are going to be speaking in favor of this bill are all going to be paid by the industry.

Lissa Lucas traveled the 100 miles from her home in Cairo, West Virginia to the state capitol in Charleston Friday to testify against an oil and gas industry sponsored bill (HB 4268) that would allow companies to drill on minority mineral owners land without their consent.

Lucas began to testify to the House Judiciary Committee, but a few minutes in, her microphone was turned off.

And Lucas was dragged out of the room.

Lucas is running for the House of Delegates from Ritchie County, which has been overrun by the fracking industry.

As I tried to give my remarks at the public hearing this morning on HB 4268 in defense of our constitutional property rights, I got dragged out of House chambers, Lucas said. Why? Because I was listing out who has been donating to Delegates on the Judiciary Committee.

Lucas took to the podium and began by pointing out that the people who are going to be speaking in favor of this bill are all going to be paid by the industry.

And the people who are going to be voting on this bill are often also paid by the industry, Lucas said.

I have...

16:36

Toxic BPA Is All Over Your Receipts Are BPA Replacements More of the Same? "IndyWatch Feed Health"

BPA replacement

By Heather CallaghanEditor

Did you know that you will get 100,000 times more Bisphenol-A (BPA) from a receipt than a plastic water bottle? [1]

This year, Im doing my taxes with surgical gloves, because one of the biggest secrets is just how much toxic BPA seeps right into the skin. In fact, when triclosan, an antibiotic chemical was still in hand sanitizer, it made our bodies absorb 100x more BPA from receipts!

While we dont have to worry about triclosan in hand sanitizer anymore thanks to a recent FDA ban, BPA is still plenty toxic in its own right. Bisphenol-A (BPA), a chemical found heavily in receipts and in most plastics, cans, and other types of food and drink packaging is already linked to obesityinfertility and reproductive disorders in both genders, breast cancer, prostrate cancer, behavioral problems, brain impairment, hypertension and more.

Replacements for BPA such as BPS are abysmal as well.

...

16:34

Burkina Faso Set for Risky GM Mosquitoes Trial with No Benefits "IndyWatch Feed Health"

Genetically modified (GM) male-sterile mosquitoes are due to be released in Burkina Faso this year by the Target Malaria research consortium. However, Target Malaria, which is funded by the Bill & Melinda Gates Foundation amongst others, acknowledges that there are no benefits to the proposed GM mosquito release.

The project is set to apply for a permit to make an open release of 10,000 GM Anopheles gambiae mosquitoes: most likely in the village of Bana, west of Bobo Dioulasso. The GM mosquitoes were exported from Imperial College in London to Burkina Faso in November 2016 and are currently in contained use facilities.

Readers: Burkina Faso has rejected GM crops and brought back indigenous varieties. Is this GM mosquito release some kind of payback? Editor

The open release is intended to test the infrastructure and systems for future release for, as yet, experimental technologies, notably gene drive mosquitoes. Target Malarias ultimate aim is to make open releases of gene drive mosquitoes, with the aim of reducing the population of Anopheles gambiae mosquitoes, which can transmit the parasite that causes malaria. The hope is that reducing the mosquito population will reduce the risk of malaria transmission and hence disease incidence.

Malaria is a serious public health issue, affecting millions of people annually. Africa continues to carry a disproportionately high share of the global malaria burden, although since 2000, the malaria death rates in Africa have decreased by 66% among all age groups, and by 71% among children.ii The declines in malaria incidence and dea...

16:33

Money and Control: Why the FDA is Cracking Down on Natural Medicine Supplies "IndyWatch Feed Health"

fda ban natural medicine ban homeopathy

By Jeremiah Johnson 

If you are an avid believer in alternative medicine, you need to be aware of a growing concern. In January, the FDA had a press conference stressing the importance of protecting public health, and is moving to pass a policy to reduce the increase in safety concerns, including serious adverse events resulting from homeopathic products, the FDA says.With a record number of people turning to homeopathy, as well as the recent war on opioids in the news, the FDA decided to announce new policies on the use of homeopathic drugs.

SEE: FDA Sets Sight On Homeopathy, Part Of Larger Big Pharma Jihad

The Food and Drug Administration (FDA) has reportedly declared that virtually all homeopathic drugs are illegal. Reports that the FDA is cracking down on the use of natural medicines have been circulating for a while. However, in a recently released guidance document, the FDA is now quoted as saying that homeopathic drugs are considered new drugs that are allegedly being sold illegally. The FDA released its new guidance document last month, and sources in support of the use of homeopathic drugs are still attempting to translate what the FDA is calling a draft guidance thats been released for comment purposes only.

Source

...

15:42

Florida School Shooter Was On Medications, According To Family Friend "IndyWatch Feed Health"

Nikolas Cruz, the suspected gunman in Wednesdays school shooting that has since left 17 people dead, was likely taking medications and had a troubled past. The former Marjory Stoneman Douglas High School student was arrested...

The post Florida School Shooter Was On Medications, According To Family Friend appeared first on Vaxxter.

15:26

5 Early Warning Signs of a Child With Mental Health Problems "IndyWatch Feed Health"

This article is shared with permission from our friends at Medical Daily. Children go through different stages in their life that can alter how they perceive and interact with the world. Changes in behaviors and attitudes may be seen as just a stage or brushed off with hopes that itll will go away on its... View Article

The post 5 Early Warning Signs of a Child With Mental Health Problems appeared first on Healthy Holistic Living.

12:13

17 Year Old Man with Autism Spends Night in Frigid New York Temps After Wandering "IndyWatch Feed Health"

"We'll take these happy endings where we can get them, says the news reporter. She means well. And for her, this story is over. 17 year old Michael Barbella was at a bowling alley when he wandered (I wonder how...

12:03

The Other Mrs. Smith Will Shock and Move You "IndyWatch Feed Health"

From The Vancouver Sun: Bonnie Burstows recently released book The Other Mrs. Smith is not only an accurate portrayal of the horrific consequences of ECT but also a masterful work of literary art.

The Other Mrs. Smith is a compelling novel that invites the reader to join Naomi in her efforts to recover from the harms done to her by ECT and to reclaim the life, family and memories that had been effectively burn out by the bolts of electricity shot through her brain during this treatment. (Many readers will be surprised to learn that ECT is still being used in Canada, but by one estimate over 15,000 Canadians every year endure this questionable therapy.)

Unlike many who try to use prose fiction to make a political/sociological point, Burstow never makes her characters  stand-ins for abstractions. My particular favourite among the books richly imagined cast of characters is Gerald, a kind and generous trans man who was, as the other Mrs. Smith, the first wife of Naomis husband before coming out as trans. In many ways, Gerald is the moral centre of this complex novel, but he is not the only nuanced and memorable character.

Article

12:02

Why Arent Providers Screaming About the Mental Health Act? "IndyWatch Feed Health"

In this piece for Tales from the Madhouse, Gary Sidley critiques the Mental Health Act as a form of legal discrimination against people deemed mentally disordered and explores several explanations for mental health providers apathy concerning this issue.

A crucial assumption underpinning the MHA colludes with the myth that people suffering emotional distress and overwhelm are displaying an illness like any other and that the primary cause of affliction is some underlying brain abnormality. Many (maybe the majority) of mental health professionals, particularly those who traditionally lean towards the biological end of the spectrum, may endorse the idea that internal deficits underpin mental health problems.

An acceptance of this inherently defective model may lead professionals to collude with the idea that all those labelled with a mental disorder do not possess capacity to make their own decisions and therefore require special legislation to manage and control them. In this explanation, mental health professionals may view the human-rights violations, intrinsic to the MHA, as a necessary measure to protect their patients and the general public; in their eyes, the current legislation is deemed fit for purpose.

12:01

Petition: Protect PTSD Treatments That Work! "IndyWatch Feed Health"

The American Psychological Association recently issued a guideline recommending only short-term, structured, and symptom-focused therapies for the treatment of PTSD; the guideline may be used to restrict patients from longer term, more intensive forms of talk therapy. As a result, the Coalition to Preserve PTSD Treatment Choice has put forth a petition asking the APA to re-evaluate their new guideline. To sign the petition, click here.

11:59

Why Should Suicide (Or Voluntary Death) Be a Civil Right? "IndyWatch Feed Health"

Well, first of all, because it already is. This is not a theoretical proposition, but a self-evident truth, as the original inventors of the concept of civil rights (the author of the U.S. Constitution) put it. They talked about a right to life, not an obligation or duty to live, and also specified that the mentioning of this particular right (as well as any others) cannot be construed to deny or disparage any other rights.

Very few people understand the significance of this today, thanks for the most part to the influence of Christianity on our culture. As even a cursory analysis of history reveals, taking ones own life wasnt regarded as an act of violence or hideous moral transgression before this religious influence took hold. Its pretty much the same deal as with homosexuality the Greeks and Romans, on the whole, were radically more accepting of it than some of our own contemporaries. Euthanasia itself is a Greek word, and its original meaning is good death, which doesnt necessarily imply outside assistance nor does it imply suicide, by the way; it simply means the kind of death that the individual deems to be good. Different schools of thought of course differed on what such goodness is, but the important thing to remember is that there was no wholesale condemnation of voluntary death in the Classical world.

The Enlightenment is often regarded as a return to pre-Christian ideas about social life  a continuation of the natural evolution of thought that was forcibly halted during the medieval period. In light of this, the legal prohibition and social condemnation of voluntary death looks more like a religious phenomenon than a moral principle with secular justification behind it, a situation akin to that of a womans right to make her own reproductive decisions and indeed, both issues deal with bodily autonomy. This is yet another reason why we already have a right to voluntary death: denying such a right amounts to the establishment of a religion by the government. So the real question is not why suicide should be recognized as a right, but how come that already isnt?

Moreover, I have strong reasons to believe that if people were allowed to choose their own time and manner of death, without having to fear detainment, forced medical treatment, and permanent disability in the case of failure, and to express their views on the matter without being censored or (again) having to fear dire consequences, 1) fewer suicides would occur in the first place, and 2) those that do occur would be successful, which would significantly decrease human suffering.

Even if someone isnt really determined to die by their own hand, knowing that its not allowed can be a very distressing thought to a lot of people. Think about it  isnt it comforting to think that whatever situation youre in, you have a way to get out of...

07:51

This study strongly suggests that the administration of A. blazei extract was effective in improving the consequences of cerebral malaria in mice. "IndyWatch Feed Health"

PMID:  Malar J. 2015 Aug 11 ;14:311. Epub 2015 Aug 11. PMID: 26260055 Abstract Title:  Effect of mushroom Agaricus blazei on immune response and development of experimental cerebral malaria. Abstract:  BACKGROUND: Cerebral malaria (CM) is debilitating and sometimes fatal. Disease severity has been associated with poor treatment access, therapeutic complexity and drug resistance and, thus, alternative therapies are increasingly necessary. In this study, the effect of the administration of Agaricus blazei, a mushroom of Brazilian origin in a model of CM caused by Plasmodium berghei, strain ANKA, was investigated in mice.METHODS: C57BL/6 mice were pre-treated with aqueous extract or fractions of A. blazei, or chloroquine, infected with P. berghei ANKA and then followed by daily administration of A. blazei or chloroquine. Parasitaemia, body weight, survival and clinical signs of the disease were evaluated periodically. The concentration of pro-and anti-inflammatory cytokines, histopathology and in vitro analyses were performed.RESULTS: Mice treated with A. blazei aqueous extract or fraction C, that shows antioxidant activity, displayed lower parasitaemia, increased survival, reduced weight loss and protection against the development of CM. The administration of A. blazei resulted in reduced levels of TNF, IL-1 and IL-6 production when compared to untreated P. berghei-infected mice. Agaricus blazei (aqueous extract or fraction C) treated infected mice displayed reduction of brain lesions. Although chloroquine treatment reduced parasitaemia, there was increased production of proinflammatory cytokines anddamage in the CNS not observed with A. blazei treatment. Moreover, the in vitro pretreatment of infected erythrocytes followed by in vivo infection resulted in lower parasitaemia, increased survival, and little evidence of clinical signs of disease.CONCLUSIONS: This study strongly suggests that the administration of A. blazei (aqueous extract or fraction C) was effective in improving the consequences of CM in mice and may provide novel therapeutic strategies.

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07:00

Need Help Setting Goals and Sticking to Them? "IndyWatch Feed Health"

By Dr. Mercola

Its said that about 80 percent of New Years resolutions are abandoned by the second week of February.1 This means if you made one for 2018, theres a good chance it may already have failed. Theres also a sizable number of people who set no goals at all, New Years resolutions or otherwise, in part because they may not realize the importance of goal setting and in part because they may not know how to do it.2

There are other reasons why you may avoid goal setting as well, like a fear of failure, rejection or even success, yet setting goals and sticking to them is very much a learned behavior. Similar to how you can choose to be happy, you can choose to stick to your goals and be successful. Life coach and author Tony Robbins believes success is 80 percent psychological and 20 percent strategic,3 which is empowering because it means you can harness the power of your mind to make your goals a reality.

The sad fact is that many people are not exposed to goal setting during their formative years and simply continue on without goals throughout their adulthood. Motivational speaker and author Brian Tracy explains, One of the greatest tragedies of our educational system is that you can receive 15 to 18 years of education in our schools and never once receive a single hour of instruction on how to set goals. He adds:4

Yet we find that in certain schools where goal-setting programs have been introduced since first grade, young people become excited about goal-setting even if the goal is only to increase the scores by 5 or 10 percent over the course of the semester, or to be on time every day in the course of a month.

Children become so excited about achieving goals that by the third or fourth grade, they love to go to school. They get the best grades. They are seldom absent. They are excited about themselves and about their lives.

The First Step to Achieving Your Goals? Write Them Down

It sounds incredibly simplistic, but the straightforward act of writing down your goals is perhaps the most important on your goal-setting jo...

Help Regulate Blood Pressure With Celery Seeds "IndyWatch Feed Health"

Most people are familiar with the fragrant and flavorful celery, but not everyone knows that its seeds are just as useful and as nutritious as the plants stalks. Celery seed has been especially famous in Ayurvedic medicine for thousands of years, where it is used as a diuretic, cold remedy and an anti-inflammatory medicine. But while celery seeds are well-known in Eastern medicine, only a handful of people in Western territories know about the numerous uses of this spice.1

Celery seeds are found in the flowers of the celery plant, which normally develop in the second year after cultivation. The seeds also function as the primary mode of propagation for the celery plant.

Celery seeds are usually small and dark brown, and taste and smell like celery stalks. This means that they can be used to boost the flavor of a dish and lend it an aromatic twist.2 Aside from the culinary use of celery seeds, they can be used to make an extract or oil to deal with different illnesses.

What Health Benefits Can You Get From Celery Seeds?

The celery stalk might be the most well-known and well-utilized part of the celery plant, but it does not mean that the other celery parts are any less useful. In Ayurvedic medicine, celery seeds are famous for their effect on cardiovascular health. Other benefits that you may get from this spice include:

Helps regulate blood pressure: As a natural diuretic, celery seeds may benefit patients with high blood pressure by speeding up salt excretion.3 High levels of salt in the blood can cause fluid buildup in the blood vessels, causing high blood pressure.4 Celery seeds are a natural and safer alternative to artificial diuretics or water pills that are usually prescribed by conventional physicians.

Alleviates inflammation in gout and arthritis: Celery seeds are said to contain about 20 anti-inflammatory agents, which can help alleviate pain and discomfort from gout and arthritis.5...

The Surprising Benefits of Inclined Bed Therapy "IndyWatch Feed Health"

By Dr. Mercola

Oftentimes the simplest strategies pay great dividends. Getting sensible sun exposure and grounding to the Earth are two examples. Sleeping on an incline is another. While few have heard of it, and sleeping on a horizontal surface is a well-established norm, raising the head of your bed 6 to 8 inches so that your youre sleeping on a 5-degree incline may have a number of benefits, including:

  • Improving blood circulation
  • Boosting metabolism
  • Improving glymphatic drainage from the brain
  • Improving immune system function
  • Improving respiratory function
  • Easing symptoms associated with Alzheimers, diabetes, glaucoma, migraines, multiple sclerosis, sleep apnea, acid reflux, edema, varicose veins and more

The History of Inclined Bed Therapy

Inclined bed therapy was developed two decades ago by Andrew K. Fletcher,1 a British mechanical engineer said to have an avid interest in how things work.2 He stumbled upon the theory by studying the circulatory system of plants. In trees, gravity pulls the denser sap from the top of the tree downward, which then forces the more diluted sap at the bottom to rise upward.

In other words, the interplay between gravity and the varying density of fluids is what causes the sap, which delivers nutrients within the tree, to circulate up and down in a perpetual loop.

He wondered if the same mechanism applied to the human body, and experimentation and further research convinced him that it does. In the video above,3 Fletcher performs a simple kitchen demonstration to show how circulation is caused by density changes in fluids. In private correspo...

06:37

Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. "IndyWatch Feed Health"

PMID:  Int J Oncol. 2016 Apr ;48(4):1670-8. Epub 2016 Feb 15. PMID: 26893131 Abstract Title:  Agarol, an ergosterol derivative from Agaricus blazei, induces caspase-independent apoptosis in human cancer cells. Abstract:  Agaricus blazei (A. blazei) is a mushroom with many biological effects and active ingredients. We purified a tumoricidal substance from A. blazei, an ergosterol derivative, and named it 'Agarol'. Cytotoxic effects of Agarol were determined by the MTT assay using A549, MKN45, HSC-3, and HSC-4 human carcinoma cell lines treated with Agarol. Apoptosis was detected by flow cytometry analysis. Reactive oxygen species (ROS) levels and mitochondria membrane potential (m) were also determined by flow cytometry. Western blot analysis was used to quantify the expression of apoptosis-related proteins. Agarol predominantly induced apoptosis in two p53-wild cell lines (A549 and MKN45) compared to the other p53-mutant cell lines (HSC-3 and HSC-4). Further mechanistic studies revealed that induction of apoptosis is associated with increased generation of ROS, reduced m, release of apoptosis-inducing factor (AIF) from the mitochondria to the cytosol, upregulation of Bax, and downregulation of Bcl-2. Caspase-3 activities did not increase, and z-VAD-fmk, a caspase inhibitor, did not inhibit the Agarol-induced apoptosis. These findings indicate that Agarol induces caspase-independent apoptosis in human carcinoma cells through a mitochondrial pathway. The in vivo anticancer activity of Agarol was confirmed in a xenograft murine model. This study suggestsa molecular mechanism by which Agarol induces apoptosis in human carcinoma cells and indicates the potential use of Agarol as an anticancer agent.

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06:01

These results found increasingly improved symptom score in the AndoSan group. "IndyWatch Feed Health"

PMID:  PLoS One. 2016 ;11(7):e0159288. Epub 2016 Jul 14. PMID: 27415795 Abstract Title:  Effect of the Medicinal Agaricus blazei Murill-Based Mushroom Extract, AndoSanTM, on Symptoms, Fatigue and Quality of Life in Patients with Crohn's Disease in a Randomized Single-Blinded Placebo Controlled Study. Abstract:  BACKGROUND: Ingestion of AndoSanTM, based on the mushroom Agaricus blazei Murill, has previously shown an anti-inflammatory effect through reduction of pro-inflammatory cytokines in healthy individuals and patients with Crohn's disease (CD). In this randomized single-blinded placebo-controlled study we examined whether intake of AndoSanTM also resulted in clinical effects.METHODS AND FINDINGS: 50 patients with symptomatic CD were randomized for oral daily consumption of AndoSanTM or placebo for a 21-day experimental period, in this per-protocol study. Patients reported validated scores for symptoms, fatigue and health related quality of life (HRQoL) at days 0, 14 and 21. Fecal calprotectin and general blood parameters were also analyzed. In the AndoSanTM group (n = 25) symptoms improved from baseline (day 0) to days 14 and 21, with respective mean scores (95% CI) of 5.52 (4.64-6.40), 4.48 (3.69-5.27) and 4.08 (3.22-4.94) (p

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05:46

A. blazei can be promising for the treatment of Parkinson's disease. "IndyWatch Feed Health"

PMID:  Nutr Neurosci. 2018 Feb ;21(2):97-107. Epub 2016 Sep 20. PMID: 27646574 Abstract Title:  Agaricus blazei extract attenuates rotenone-induced apoptosis through its mitochondrial protective and antioxidant properties in SH-SY5Y neuroblastoma cells. Abstract:  The present study was aimed to find out the effect of Agaricus blazei mushroom extract against rotenone-induced cellular model. SH-SY5Y neuroblastoma cells are divided into four experimental groups (control, rotenone (100nM), A. blazei (5g/ml) + rotenone (100nM), and A. blazei alone treated) based on MTT assay, cells were allowed to measure the ROS, TBARS levels, and antioxidants activities. Finally, mitochondrial transmembrane potential (MMP) and expressions of apoptotic proteins were also analyzed. Pre-treatment with A. blazei significantly enhanced cell viability, attenuated rotenone-induced ROS, MMP, and apoptosis. Our results indicated that anti-apoptotic properties of this natural compound due to its antioxidant and mitochondrial protective function protect rotenone-induced cytotoxicity. Therefore, it may be concluded that A. blazei can be further developed as a promising drug for the treatment of Parkinson's disease (PD).

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05:11

The results from this model for colorectal cancer shows significant protection of orally administered Andosan against development of intestinal cancer. "IndyWatch Feed Health"

PMID:  PLoS One. 2016 ;11(12):e0167754. Epub 2016 Dec 21. PMID: 28002446 Abstract Title:  The Agaricus blazei-Based Mushroom Extract, Andosan, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse. Abstract:  BACKGROUND: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine. Agaricus blazei Murill (AbM) is an edible Basidiomycetes mushroom that has been used in traditional medicine against cancer and other diseases. The mushroom contains immunomodulating-glucans and is shown to have antitumor effects in murine cancer models. Andosan is a water extract based on AbM (82%), but it also contains the medicinal Basidiomycetes mushrooms Hericeum erinaceus and Grifola frondosa.METHODS AND FINDINGS: Tap water with 10% Andosan was provided as the only drinking water for 15 or 22 weeks to A/J Min/+ mice and A/J wild-type mice (one single-nucleotide polymorphism (SNP) difference), which then were exsanguinated and their intestines preserved in formaldehyde and the serum frozen. The intestines were examined blindly by microscopy and also stained for the tumor-associated protease, legumain. Serum cytokines (pro- and anti-inflammatory, Th1-, Th2 -and Th17 type) were measured by Luminex multiplex analysis. Andosan treated A/J Min/+ mice had a significantly lower number of adenocarcinomas in the intestines, as wellas a 60% significantly reduced intestinal tumor load (number of tumors x size) compared to control. There was also reduced legumain expression in intestines from Andosan treated animals. Moreover, Andosan had a significant cytotoxic effect correlating with apoptosis on the human cancer colon cell line, Caco-2, in vitro. When examining serum from both A/J Min/+ and wild type mice, there was a significant increase in anti-tumor Th1 type and pro-inflammatory cytokines in the Andosan treated mice.CONCLUSIONS: The results from this mouse model for colorectal cancer shows significant protection of orally administered Andosan against development of intestinal cancer. This is supported by the finding of less legumain in intestines of Andosan treated mice and increased systemic Th1 cytokine response. The mechanism is probably both immuno-modulatory and growth inhibition of tumor cells by induction of apoptosis.

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04:55

Agaricus blazei Murill polysaccharides inhibited cadmium induced effects on chicken peripheral blood lymphocytes. "IndyWatch Feed Health"

PMID:  Biol Trace Elem Res. 2017 Nov ;180(1):153-163. Epub 2017 Mar 10. PMID: 28283953 Abstract Title:  The Effects of Agaricus blazei Murill Polysaccharides on Cadmium-Induced Apoptosis and the TLR4 Signaling Pathway of Peripheral Blood Lymphocytes in Chicken. Abstract:  In this study, we investigated the effects of Agaricus blazei Murill polysaccharides (ABP) on cadmium (Cd)-induced apoptosis and the TLR4 signaling pathway of chicken peripheral blood lymphocytes (PBLs). Seven-day-old healthy chickens were randomly divided into four groups, and each group contained 20 males. The cadmium-supplemented diet group (Cd group) was fed daily with full feed that contained 140 mg cadmium chloride (CdCl)/kg and 0.2 mL saline. The A. blazei Murill polysaccharide diet group (ABP group) was fed daily with full feed with 0.2 mL ABP solution (30 mg/mL) by oral gavage. The cadmium-supplemented plus A. blazei Murill polysaccharide diet group (Cd + ABP group) was fed daily with full feed containing 140 mg CdCl/kg and 0.2 mL ABP solution (30 mg/mL) by gavage. The control group was fed daily with full feed with 0.2 mL saline per day. We measured the apoptosis rate and messenger RNA (mRNA) levels of apoptosis genes (caspase-3, Bax, and Bcl-2), the mRNA levels of TLR4 and TLR4 signaling pathway-related factors (MyD88, TRIF, NF-B, and IRF3), the TLR4 protein expression, and the concentrations of inflammatory cytokines (IL-1, IL-6, and TNF-) in chicken PBLs. The results showed that the PBL apoptosis rate was significantly increased, the mRNA levels of caspase-3 and Bax were significantly increased, while that of Bcl-2 was significantly reduced. The Bax/Bcl-2 ratio was significantly increased in the Cd group at 20, 40, and 60 days after treatment compared with that in the control group. After treatment with ABP, the above changes were clearly suppressed. At the same time, ABP reduced the concentrations of IL-1, IL-6, and TNF- induced by Cd. We also found that ABP inhibited the TLR4 mRNA level and protein expression and inhibited the mRNA levels of MyD88, TRIF, NF-B, and IRF3. The results demonstrated that Cd could induce apoptosis, activate the TLR4 signaling pathway, and induce the expression of inflammatory cytokines in chicken PBLs, and that the administration of ABP clearly inhibited Cd-induced effects on chicken PBLs.

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04:33

These preliminary results demonstrated anti-genotoxic properties of Agaricus blazei. "IndyWatch Feed Health"

PMID:  Oxid Med Cell Longev. 2017 ;2017:8759764. Epub 2017 Feb 21. PMID: 28316757 Abstract Title:  Antigenotoxic Properties ofagainst Hydrogen Peroxide in Human Peripheral Blood Cells. Abstract:  The ability ofmushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against HO-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay. The results showed better antigenotoxic properties ofon the interventional level, respectively, after treatment.in concentration of 250g/mL after treatment was most efficient in regard to its action against DNA damage. The evaluation of repair kinetics showed decrease in HOinduced DNA damage 15min after the application of, reaching the maximum potency after 30min. Analysis of antioxidant properties ofrevealed strongOH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. In regard to our findings, we can conclude that our preliminary results demonstrated antigenotoxic properties ofand its strongOH scavenging ability. Mechanisms underlying its properties should be further evaluated in in vivo studies.

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04:19

Agaricus blazei regulates the cell-mediated immunity of RAW 264.7 cells. "IndyWatch Feed Health"

PMID:  Food Funct. 2017 Apr 19 ;8(4):1475-1480. PMID: 28322382 Abstract Title:  Regulation of RAW 264.7 cell-mediated immunity by polysaccharides from Agaricus blazei Murill via the MAPK signal transduction pathway. Abstract:  Agaricus blazei Murill (ABM) is a common anticancer folk remedy. Its active ingredients, i.e., polysaccharides, have been isolated and exhibit indirect tumor-suppressing activity via immunological activation. The effects of polysaccharides derived from A. blazei Murill (ABMP) on RAW 264.7 cells were examined by western blotting and real-time reverse transcription polymerase chain reaction (RT-PCR). The effects of 500, 1000, and 2000g mLABMP on the growth of RAW 264.7 cells were evaluated by measuring the ODvalue; the optimum concentration was found to be 1000g mL. Based on the RT-PCR results, the expression levels of JNK, ERK, and p38 decreased substantially in lipopolysaccharide (LPS)-induced RAW 264.7 cells treated with ABMP. In RAW 264.7 cells treated with LPS, the protein expression levels of JNK, ERK, and p38 were decreased, as were the levels of phosphorylated JNK, ERK, and p38. These results indicate that the MAPK signal transduction pathway is a potential mechanism by which ABMP regulates the cell-mediated immunity of RAW 264.7 cells.

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04:07

Agaricus blazei polysaccharide has beneficial effects on cadmium toxicity on peripheral blood lymphocytes. "IndyWatch Feed Health"

PMID:  Biol Trace Elem Res. 2018 Jan ;181(1):122-132. Epub 2017 Apr 21. PMID: 28432527 Abstract Title:  Effects of Agaricus blazei Murill Polysaccharide on Cadmium Poisoning on the MDA5 Signaling Pathway and Antioxidant Function of Chicken Peripheral Blood Lymphocytes. Abstract:  This experimental study investigated the effect of Agaricus blazei Murill polysaccharide (ABP) on cadmium (Cd) poisoning on the melanoma differentiation-associated gene 5 (MDA5) signaling pathway and antioxidant function of peripheral blood lymphocytes (PBLs) in chickens. The experiments were divided into four groups: 7-day-old chickens with normal saline (0.2 mL single/day), Cd (140 mg/kg), ABP (30 mg/mL, 0.2 mL single/day), and Cd + ABP(140 mg/kg/day + 0.2 mL ABP). Peripheral blood was collected on the 20th, 40th, and 60th days for each group, and PBLs were separated. We attempted to detect the expression of MDA5, downstream signaling molecules, and convergence protein (interferon promoter-stimulating factor 1); transcription factors (IRF3 and NF-B); the content of cytokines (IL-1, IL-6, TNF-, and IFN-) in PBLs; and the antioxidant index of superoxide dismutase (SOD), malondialdhyde (MDA), and glutathione peroxidase (GSH-Px). Theresults showed that ABP can reduce the accumulation of Cd in the peripheral blood of chickens; reduce the expression of MDA5 and downstream signaling molecules; and reduce the content of IL-1, IL-6, TNF-, and IFN- in PBLs of chickens. The activity of antioxidant enzymes (SOD and GSH-Px) significantly increased, and the content of MDA decreased. These results showed that they have a certain protective effect of ABP on Cd poisoning in chicken PBLs caused by injury.

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03:28

A. blazei extract offers a promising and new therapeutic lead for treatment of Parkinson's disease. "IndyWatch Feed Health"

PMID:  Nutr Neurosci. 2017 Jun 19:1-10. Epub 2017 Jun 19. PMID: 28628424 Abstract Title:  Agaricus blazei extract abrogates rotenone-induced dopamine depletion and motor deficits by its anti-oxidative and anti-inflammatory properties in Parkinsonic mice. Abstract:  Neuroinflammation and oxidative damage are the two main malfactors that play an important role in the pathogenesis of experimental and clinical Parkinson's disease (PD). The current study was aimed to study the possible anti-oxidant and anti-inflammatory effects of the methanolic extract of Agaricus blazei (A. blazei) against rotenone-induced PD in mice. Male Albino mice were randomized and divided into the following groups: control, treated with rotenone (1mg/kg/day), co-treated with rotenone and A. blazei (50, 100, and 200mg/kg b.w.), and treated with A. blazei alone (200mg/kg b.w.). After the end of the experimental period, behavioral studies, biochemical estimations, and protein expression patterns of inflammatory markers were studied. Rotenone treatment exhibited enhanced motor impairments, neurochemical deficits, oxidative stress, and inflammation, whereas oral administration of A. blazei extract attenuated the above-said indices. Even though further research is needed to prove its efficacy in clinical studies, the results of our study concluded that A. blazei extract offers a promising and new therapeutic lead for treatment of PD.

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02:58

Agaricus blazei polysaccharide has a protective effect on cadmium induced damage in chicken spleens. "IndyWatch Feed Health"

PMID:  Biol Trace Elem Res. 2017 Oct 14. Epub 2017 Oct 14. PMID: 29032405 Abstract Title:  Agaricus blazei Murill Polysaccharides Protect Against Cadmium-Induced Oxidative Stress and Inflammatory Damage in Chicken Spleens. Abstract:  Agaricus blazei Murill polysaccharide (ABP) has exhibited antioxidant and immunoregulatory activity. The aim of this study was to investigate the effect of ABP on cadmium (Cd)-induced antioxidant functions and inflammatory damage in chicken spleens. In this study, groups of 7-day-old chickens were fed with normal saline (0.2 mL single/day), CdCl(140 mg/kg/day), ABP (30 mg/mL, 0.2 mL single/day), and Cd + ABP (140 mg/kg/day + 0.2 mL ABP). Spleens were separated on the 20th, 40th, and 60th day for each group. The Cd contents, expression of melanoma-associated differentiation gene 5 (MDA5) and its downstream signaling molecules (interferon promoter-stimulating factor 1 (IPS-1), transcription factors interferon regulatory factor 3 (IRF3), and nuclear factor kappa-light chain-enhancer of activated B cells (NF-B)), the content of cytokines (interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor- (TNF-) and beta interferon (IFN-)), protein levels of heat shock proteins (HSPs), levels of malondialdehyde (MDA), activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), and histopathological changes of spleens were detected on the 20th, 40th, and 60th day. The results showed that ABP significantly reduced the accumulation of Cd in the chicken spleens and reduced the expression of MDA5, IPS-1, IRF-3, and NF-B; their downstream inflammatory cytokines, IL-1, IL-6, TNF-, and IFN-; and the protein levels of HSPs (HSP60, HSP70, and HSP90) in spleens. The activities of antioxidant enzymes(SOD and GSH-Px) significantly increased, and the level of MDA decreased in the ABP + Cd group. The results indicate that ABP has a protective effect on Cd-induced damage in chicken spleens.

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02:49

Results suggest that Agaricus blazei polysaccharide for the mitigation of damage induced by cadmium in chicken testis. "IndyWatch Feed Health"

PMID:  Biol Trace Elem Res. 2017 Nov 10. Epub 2017 Nov 10. PMID: 29127548 Abstract Title:  Protective Effect of Agaricus blazei Polysaccharide Against Cadmium-Induced Damage on the Testis of Chicken. Abstract:  Cadmium (Cd) exposure can cause reproductive toxicity through oxidative stress and inflammatory response. A polysaccharide extract of the edible mushroom Agaricus blazei Murill has been isolated and exhibits antioxidant activity and immunoregulatory effect. The aim of this study was to investigate the protective role of Agaricus blazei polysaccharide (ABP) against Cd-induced damage in chicken testis through enhancing antioxidant activity and alleviating inflammatory response. One hundred twenty healthy 7-day-old Hy-Line male chickens (Harbin, China) were randomly divided into four groups, and each group consisted of 30 chickens: Normal control was fed daily with full feed and 0.2 mL distilled water per day via oral gavage; Cd-treated group was fed daily with full feed that contained 140 mg/kg CdCland 0.2 mL distilled water per day by gavage; Polysaccharide-treated group was fed daily with full feed with 0.2 mL ABP(30 mg/ml) solution per day via oral gavage; Cd/polysaccharide-treated group was fed daily with full feed containing 140 mg/kg CdCland 0.2 mL ABP(30 mg/ml) solution per day by gavage. On the 20, 40, and 60 days, the testis was immediately removed. The contents of Cd in the testis, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), malondialdehyde (MDA) production, messenger RNA (m RNA) levels of tumor necrosis factor-alpha (TNF-), interleukin-1 beta (IL-1), and interleukin-6 (IL-6), protein expressions of heat shock proteins (HSPs) (HSP60, HSP70, and HSP90), and the histopathological changes of the testis were determined. The results indicated that ABP improved Cd-caused testicular tissue damageby increasing the SOD and GSH-Px activities: decreasing the Cd accumulation and MDA content, mRNA levels of TNF-, IL-1, and IL-6, and protein expressions of HSP60, HSP70, and HSP90. Results suggest that ABP for the mitigation of damage induced by cadmium in chicken testis through enhancing antioxidant activity and alleviating Inflammatory response.

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02:14

Cytotoxic effect on human myeloma cells and leukemic cells by Agaricus blazei. "IndyWatch Feed Health"

PMID:  Biomed Res Int. 2017 ;2017:2059825. Epub 2017 Nov 7. PMID: 29238712 Abstract Title:  Cytotoxic Effect on Human Myeloma Cells and Leukemic Cells by theMurill Based Mushroom Extract, Andosan. Abstract:  Murill is an edible mushroom of the Basidiomycetes family, which has been found to contain a number of compounds with antitumor properties, such as proteoglycans and ergosterol. In the present investigation, we show that the commercial mushroom product Andosan, which contains 82.4%Murill, together with medicinal mushrooms(14.7%) and(2.9%), has a cytotoxic effect on primary myeloma cells, other myeloma cell lines, and leukemia cell linesAlthough the exact content and hence the mechanisms of action of the Andosan extract are unknown, we have found in this investigation indications of cell cycle arrest when myeloma cell lines are cultivated with Andosan. This may be one of the possible explanations for the cytotoxic effects of Andosan.

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02:01

erinacine A-enriched HE mycelium could be an attractive agent for the treatment of depressive disorders. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2018 Jan 24 ;19(2). Epub 2018 Jan 24. PMID: 29364170 Abstract Title:  Erinacine A-Enriched Hericium erinaceus Mycelium Produces Antidepressant-Like Effects through Modulating BDNF/PI3K/Akt/GSK-3 Signaling in Mice. Abstract:  Antidepressant-like effects of ethanolic extract of(HE) mycelium enriched in erinacine A on depressive mice challenged by repeated restraint stress (RS) were examined. HE at 100, 200 or 400 mg/kg body weight/day was orally given to mice for four weeks. After two weeks of HE administration, all mice except the control group went through with 14 days of RS protocol. Stressed mice exhibited various behavioral alterations, such as extending immobility time in the tail suspension test (TST) and forced swimming test (FST), and increasing the number of entries in open arm (POAE) and the time spent in the open arm (PTOA). Moreover, the levels of norepinephrine (NE), dopamine (DA) and serotonin (5-HT) were decreased in the stressed mice, while the levels of interleukin (IL)-6 and tumor necrosis factor (TNF)- were increased. These changes were significantly inverted by the administration of HE, especially at the dose of 200 or 400 mg/kg body weight/day. Additionally, HE was shown to activate the BDNF/TrkB/PI3K/Akt/GSK-3 pathways and block the NF-B signals in mice. Taken together, erinacine A-enriched HE mycelium could reverse the depressive-like behavior caused by RS and was accompanied by the modulation of monoamine neurotransmitters as well as pro-inflammatory cytokines, and regulation of BDNF pathways. Therefore, erinacine A-enriched HE mycelium could be an attractive agent for the treatment of depressive disorders.

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01:40

H. erinaceus a polysaccharide was effective in preventing gastric cancer progression. "IndyWatch Feed Health"

PMID:  Int J Med Mushrooms. 2017 ;19(12):1053-1060. PMID: 29431066 Abstract Title:  A Polysaccharide Isolated from Mycelia of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Induced Apoptosis in Precancerous Human Gastric Cells. Abstract:  Hericium erinaceus is typically used in traditional Chinese medicine for mucosal protection, healing of gastric ulcers, and treatment of gastritis. We purified from the cultured mycelia of H. erinaceus a polysaccharide with anti-gastric ulcer and antigastritis activity, but its effects on gastric malignancy have not been elucidated. We examined the differential effects of this purified polysaccharide, named EP-1, on the human gastric (GES-1) cell line and a precancerous cell line (MC) that was transformed from GES-1 using N-methyl-N'-nitro-N-nitrosoguanidine. We observed that the polysaccharide potently induced cell apoptosis and cell cycle arrest at the G0/G1 phase in the MC cell line but did not have any effect on the GES-1 cell line at the same doses. Further mechanistic studies revealed that the polysaccharide exerted its activity through an apoptosis-associated pathway by modulating the expression of Bax, Bcl-2, and caspase-3. Differential effects of the polysaccharide on the GES-1 and MC cell lines indicate that the polysaccharide was effective in preventing gastric cancer progression.

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01:31

Chemical and antioxidant properties of wild edible mushrooms from Argentina. "IndyWatch Feed Health"

PMID:  Molecules. 2016 Sep 8 ;21(9). Epub 2016 Sep 8. PMID: 27617993 Abstract Title:  Chemical and Antioxidant Properties of Wild Edible Mushrooms from Native Nothofagus spp. Forest, Argentina. Abstract:  This study addresses issues regarding chemical and bioactive properties of nine wild edible mushrooms from native Nothofagus forest from Patagonia, Argentina. Macronutrients, sugars, fatty acids, tocopherols, organic acids, phenolic compounds and antioxidant properties were determined. Protein was found in high levels and varied between 3.35 g/100 g dw in Cyttaria hariotii and 22.29 g/100 g dw in Lepista nuda. All of them presented mannitol and trehalose as main sugars. Mannitol was significantly higher in Ramaria patagonica, although absent in Fistulina endoxantha, whereas trehalose predominated in Aleurodiscus vitellinus, Hydropus dusenii, Cortinarius magellanicus, C. hariotii, Grifola gargal and L. nuda, ranging from 1.15 to 10.26 g/100 g dw; it was absent in R. patagonica. The major fatty acid found was linoleic acid, followed by oleic acid and palmitic acid. All species presented oxalic and fumaric acids, while some also had malic, quinic and citric acids. Tocopherols composition was variable. Cortinarius magellanicus presented significantly higher contents of both-tocopherol and -tocopherol. R. patagonica presented the best results in all the antioxidant activity assays (EC50 values 1 mg/mL) and the highest content of phenolic compounds presenting gallic, p-hydroxybenzoic, p-coumaric and cinnamic acids. This study constitutes the first report on chemical composition and nutritional value of most of these edible mushroom species. Furthermore, it provides important information necessary to characterize and define the use of these species as gastronomic delicacies, functional foods and sources of bioactive compounds.

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01:08

G. gargal is a promising functional food to prevent and treat diabetes and lifestyle-related diseases. "IndyWatch Feed Health"

PMID:  Int J Med Mushrooms. 2017 ;19(12):1071-1081. PMID: 29431068 Abstract Title:  Blood Glucose-Reducing and Fat-Reducing Effects of a Novel Medicinal Mushroom, Grifola gargal (Agaricomycetes). Abstract:  Grifola gargal Singer is a medicinal mushroom with biological effects such as antiatherogenic and antiosteoporotic activities. The objective of this study was to examine a blood glucose-reducing effect and a fatreducing effect of G. gargal supplementation in vivo. The effects of G. gargal powder (GGP) in a high-molecular weight hot water extract (GGH) and a low-molecular weight hot water extract (GGL) on blood glucose were investigated in streptozotocin (STZ)-induced diabetic ICR mice (STZ diabetic mice). A significant decrease in blood glucose was observed after 5 weeks of GGL supplementation (fraction with a molecular weight 6000 Da) in STZ diabetic mice. In the next test, we examined the antihyperglycemic and fat-reducing effects of GGL in diet-induced obesity (DIO) mice fed a high-fat diet. GGL facilitated reductions in blood glucose and body fat. This study confirms, to our knowledge for the first time, that administration of G. gargal extract has antihyperglycemic and body fat-reducing effects in STZ diabetic mice and DIO mice. Therefore, G. gargal is a promising functional food to prevent and treat diabetes and lifestyle-related diseases.

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01:03

Amauroderma rugosum extract is a good source of lipid-ameliorating agents in the management of dyslipidemia. "IndyWatch Feed Health"

PMID:  Int J Med Mushrooms. 2017 ;19(12):1101-1111. PMID: 29431071 Abstract Title:  Lipid-Modulating Effect of Black Lingzhi Medicinal Mushroom, Amauroderma rugosum (Agaricomycetes), on Oleate-Induced Human Hepatocellular Liver Carcinoma Cells. Abstract:  Dyslipidemia is the key precursor of atherosclerotic cardiovascular disease. The aim of this study was to investigate the lipid-modifying potential of organic solvent-partitioned extracts from fruiting bodies of Amauroderma rugosum in vitro using oleate-induced human hepatocellular liver carcinoma (HepG2) cells. Our results demonstrated that oleate-induced HepG2 cells treated with ethyl acetate (EA) extract greatly decreased intracellular and secreted total triglyceride (TG) and total cholesterol (TC) compared with other extracts. Further investigation of cellular expression of selected apolipoproteins also revealed that oleate-induced HepG2 cells treated with the EA extract best attenuated the apolipoprotein (Apo) profile by downregulating ApoB-100 and ApoE while upregulating ApoA1. Because both ApoB-100 and ApoE are key components of low-density lipoprotein (LDL) and very LDL (VLDL), which are recognized as"bad cholesterol,"this result indicates that treatment with the EA extract inhibited LDL and VLDL production in oleate-induced HepG2 cells. On the other hand, increasing ApoA1 evidence shows antiatherogenic benefits to increasing ApoA1, the key component of high-density lipoprotein (HDL), particularly in relation to its role in promoting reverse cholesterol transport and preventing LDL oxidation; this indicates that the EA extract upregulated the production of HDL ("good cholesterol"). Hence, the EA extract is a good source of lipid-ameliorating agents in the management of dyslipidemia.

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00:27

Changes in polyphenol composition and bioactivity of the native Chilean white strawberry after in vitro gastrointestinal digestion. "IndyWatch Feed Health"

PMID:  Food Res Int. 2018 Mar ;105:10-18. Epub 2017 Nov 8. PMID: 29433189 Abstract Title:  Changes in polyphenol composition and bioactivity of the native Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) after in vitro gastrointestinal digestion. Abstract:  The Chilean white strawberry (Fragaria chiloensis spp. chiloensis f. chiloensis) is a semi-domesticated strawberry with high polyphenol content and antioxidant activity occurring in southern Chile. The aim of this work was to compare the composition and bioactivity of the polyphenol-enriched fruit extract (PEE) before and after simulated gastrointestinal digestion (GID). Results show a decrease by>50% in the total phenolic (TP) content at the end of the GID, compared to the non-digested PEE. A reduction in the antioxidant capacity of the PEEs was observed after GID by means of DPPH, FRAP, TEAC and anion superoxide assays. After simulated GID the PEE significantly inhibited-glucosidase with an ICvalue of 3.13g/mL. The inhibition of pancreatic lipase was reduced by 95% after GID. All the PEEs did not show inhibitory effect towards -amylase throughout the GID. In the same way, the PEEs did not significantly protect human gastric adenocarcinoma (AGS) cells against HO-induced stress. Thirty eight compounds were tentatively identified in the non-digested PEE. The compounds that were more affected by the simulated GID were simple phenolics. After the GID, only 33 and 25 compounds were detected, in the gastric and intestinal steps, respectively. These results evidence the changes elicited by GID on the bioactivity and polyphenolic composition of the white strawberry.

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00:22

Bisphenol A and dibutyl phthalate affect the expression of juxtacrine signaling factors in rat testis. "IndyWatch Feed Health"

PMID:  Chemosphere. 2018 Feb 5 ;199:182-190. Epub 2018 Feb 5. PMID: 29438945 Abstract Title:  Bisphenol A and dibutyl phthalate affect the expression of juxtacrine signaling factors in rat testis. Abstract:  The study was designed to examine the effects of model plastic derived compounds, bisphenol A (BPA) and dibutyl phthalate (DBP), on juxtacrine communication in adult rat testis, by evaluating the expression of Notch pathway components. Testicular explant were exposed in vitro to BPA (510M, 2.510M, 510M) or DBP (10M, 10M, 10M) for 24h. To determine the expression of Notch1, Dll4, Hey1, Hes1 and Hey5 real-time RT-PCR was used. Protein levels and localization of NOTCH1 receptor, its ligand DLL4 as well as HEY1, HES1 and HEY5 factors were detected by western blot analysis and immunohistochemistry, respectively. Upregulation of Notch1, Dll4 and Hey1 at the mRNA and protein level was demonstrated in testis explants after BPA and DBP treatment (p

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00:21

Bisphenol A and dibutyl phthalate affect the expression of juxtacrine signaling factors in rat testis. "IndyWatch Feed Health"

PMID:  Chemosphere. 2018 Feb 5 ;199:182-190. Epub 2018 Feb 5. PMID: 29438945 Abstract Title:  Bisphenol A and dibutyl phthalate affect the expression of juxtacrine signaling factors in rat testis. Abstract:  The study was designed to examine the effects of model plastic derived compounds, bisphenol A (BPA) and dibutyl phthalate (DBP), on juxtacrine communication in adult rat testis, by evaluating the expression of Notch pathway components. Testicular explant were exposed in vitro to BPA (510M, 2.510M, 510M) or DBP (10M, 10M, 10M) for 24h. To determine the expression of Notch1, Dll4, Hey1, Hes1 and Hey5 real-time RT-PCR was used. Protein levels and localization of NOTCH1 receptor, its ligand DLL4 as well as HEY1, HES1 and HEY5 factors were detected by western blot analysis and immunohistochemistry, respectively. Upregulation of Notch1, Dll4 and Hey1 at the mRNA and protein level was demonstrated in testis explants after BPA and DBP treatment (p

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00:13

Phthalates exposure may be related to statistically significant ALT and AST serum levels increment as well as with increased BMI. "IndyWatch Feed Health"

PMID:  Environ Monit Assess. 2017 Dec 13 ;190(1):17. Epub 2017 Dec 13. PMID: 29234897 Abstract Title:  Potential influence of the phthalates on normal liver function and cardiometabolic risk in males. Abstract:  Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting. MEP was found in 28.43% (29/102) volunteers, while MEHP was detected among 20.59% (21/102) participants. Statistically significant increment in transaminase serum levels was observed in MEP-positive normal weight subgroup. Linear correlation was obtained between MEP concentration inurine samples and triglyceride (TG) serum levels (r=0.33; p 

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Wednesday, 14 February

23:47

Maternal exposure to several EDCs was associated with adverse neurodevelopmental performances among the children aged 1-2years. "IndyWatch Feed Health"

PMID:  Sci Total Environ. 2017 Dec 16 ;624:377-384. Epub 2017 Dec 16. PMID: 29258038 Abstract Title:  Association between maternal exposure to major phthalates, heavy metals, and persistent organic pollutants, and the neurodevelopmental performances of their children at 1 to 2years of age- CHECK cohort study. Abstract:  Exposure of the developing fetus and infants to toxic substances can cause serious lifelong health consequences. Several chemicals have been associated with adverse neurodevelopmental disorders in the early life stages of humans. However, most epidemiological studies have focused on a limited number of chemicals, and hence may exclude important chemicals from consideration or result in conclusions built on associations by chance. In the present study, we investigated the chemical exposure profile of the women, and associated these with the early neurodevelopmental performance of their offspring at 13-24months of age. The chemicals assessed include four phthalates, bisphenol A, three heavy metals, 19 polychlorinated biphenyls (PCBs), 19 organochlorine pesticides, and 19 polybrominated diphenyl ethers, which were measured from urine, whole blood, serum, and/or breastmilk of the pregnant or lactating women. For neurodevelopmental performance, the Bayley Scales of Infant Development-II (BSID-II), Social Maturity Scale (SMS), and Child Behavior Checklist (CBCL) were measured from a total of 140 toddlers. Among the measured chemicals, monoethyl phthalate (MEP) in maternal urine was significantly associated with early mental, psychomotor, and social development. In addition, breast milk di-ethylhexyl phthalate (DEHP) metabolite and blood lead concentrations were inversely associated with mental and psychomotor development indices, respectively. Maternal blood PCB153, heavy metals, and urinary MEP levels were also higher among the children with behavioral problems, as indicated by the CBCL range. Taken together, maternal exposure to several EDCs such as PCBs and DEHP was associated with adverse neurodevelopmental performances among the children aged 1-2years. Confirmation of these association in larger populations, as well as longer-term consequences of such exposure warrant further investigation.

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22:24

Fluoride debate resurrected by Sarnia Mayor Mike Bradley "IndyWatch Feed Health"

Sarnia Mayor Mike Bradley wants residents to have a vote on fluoride. He is recommending the city have a plebiscite about the controversial compound included on the next civic-election ballot.

Bradley said whether or not to fluoridate drinking water is a perennial issue in many Canadian cities.

Ive been on 10 different councils and every council term this issue comes up, he said.

Bradley said the results would be non-binding, but would let council know how the public felt about the issue.

In 2013, Sarnia city council voted 5-4 in favour of getting rid of fluoride. The decision changed nothing, however. Sarnia is one of six municipalities to get their water from the Lambton Area Water Supply System (LAWSS). Fluoride is added to the water at one central water treatment plant, and the water is then pumped to the different municipalities. Unless four of those six municipalities vote to get ride of the controversial compound, the water continues to be fluoridated.

Susan MacFarlane is general manager at LAWSS.

Weve had many votes over the years, said Susan MacFarlane, general manager at LAWSS, adding that theyve always had fluoride at the plant.

Bradley said the last vote taken on fluoride at LAWSS ended in a 3-3 vote.

Fluoride since 1971

Bradley said there hasnt been a referendum on fluoride in Sarnia since 1971, when it was decided to add it to the water.

Sarnia back in the 50s and 60s, kids here had terrible teeth and it was the dentists who pushed for fluoride being in the water, he said. Things have changed.

Bradley said he supports keeping fluoride in the water.

However, I also respect that the next council, when it does come back up, should have the right to know what the public speaks, he said, adding the that a bonus of having a ballot question is that it can increase voter turnout.

Weve had ballot questions in the past that have brought people out to vote specifically on that issue, and then hopefully they vote for mayor and council, he said.

21:18

Fluoride coming to drinking water at Naval Base Kitsap-Bangor "IndyWatch Feed Health"

The Navy is in the process of installing a water fluoridation system at Bangor to comply with a Department of Defense directive issued in 2013.

Those who turn on the tap for a drink at Naval Base Kitsap-Bangor in 2020 will get water that includes fluoride.

The Navy is in the process of installing a water fluoridation system at Bangor to comply with a Department of Defense directive issued in 2013, said base spokesman Jake Chappelle.

That year, the Office of the Undersecretary of Defense mandated that all military installations serving more than 3,300 personnel through their own water treatment facilities install the systems.

Bangor has 9,000 military and civilian personnel on base.

Then-Assistant Secretary of Defense for Health Affairs, Dr. Jonathon Woodson, advocated for the institution of such a policy, since providing optimally fluoridated water at DoD installations helps to improve and sustain the military readiness and health of military personnel, Chappelle said.

Current research and scientific evidence shows that providing optimally fluoridated water directly reduces the risk of dental decay, he said.

The federal Department of Health and Human Services recommends a level of 0.7 milligrams of fluoride as the optimal level in drinking water.

It will cost a little more than $447,000 to install the system. It will not be operational until 2020 because of the required training and hiring of system operators, Chappelle said.

No other Naval Base Kitsap installations currently have or are planned to receive the fluoridation systems, because they do not meet the Department of Defenses base-size requirement of serving 3,300 personnel with a water system.

Joint Base Lewis-McChord has fluoridated water systems.

Kitsap County has one of the highest numbers of fluoridated public water systems in the state, according to the state Department of Health. Water systems with fluoride include the cities of Bainbridge Island, Poulsbo and Port Orchard; Bainbridges Rockaway Beach Water; the Manchester Water District; and Port Orchards West Sound Utility District #1.

Residents of the city of Bremerton voted down a proposal to fluoridate the water in 1999.

*Original article online at http://www.kitsapsun.com/story/news/local/2018/02/14/fluoridation-coming-bangors-drinking-water/329855002/

...

20:42

Franklin officials: Malfunction in fluoridation equipment not an emergency "IndyWatch Feed Health"

FRANKLIN A mechanical malfunction of fluoridation equipment led to a violation of state drinking water standards for some water system customers, according to a press release from the Franklin city managers office.

An overfeed of the chemical additive at the Barrett Flats Water Treatment Plant led to fluoride levels that exceeded that state maximum of 2 milligrams per liter, according to the statement. Officials did not specify what level of contamination the fluoride reached or how many people were affected, but they advised that children younger than 9 years old be provided alternative sources of drinking water until they are notified.

The excess fluoride was discovered Feb. 8 and is believed to have started on Feb. 1, according to the statement. The fluoridation system was shut down, hydrants have been flushed and storage tanks are being drawn down and refilled with new water in an effort to lower the fluoride level as officials from the city and the Pennsylvania Department of Environmental Protection continue testing water throughout the system. Residents were encouraged to use water for bathing and laundry as part of the effort to purge water with excess fluoride from the system.

Excess fluoride can cause staining or pitting of teeth in young children and can even increase the risk of bone disease, but city officials downplayed the risk.

This is not an emergency, the news release stated. If it had been, you would have been notified immediately.

Cases of bottled water were available for those affected at the Franklin Fire Department, 113 13th St.

*Original article online at http://www.meadvilletribune.com/news/local_news/franklin-officials-malfunction-in-fluoridation-equipment-not-an-emergency/article_a319f2d5-6279-5275-9310-30e61b471119.html

19:05

The CDC's Fictional Flu Death Stats and Tamiflu's Lethal Side Effects "IndyWatch Feed Health"

"You dont sell the drug, you sell the disease."  

~ George Merck, founder of Merck

Flu season, or at least reporting on it, has reached a fever pitch but the flu propaganda telling you it may be dangerous NOT to take Tamiflu and/or the flu vaccine may be a far greater risk to your health than the flu itself.

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Tuesday, 13 February

Sunday, 11 February

02:04

How to Cut Your Water Bill in Half With Ollas "IndyWatch Feed Health"

Source: How to Cut Your Water Bill in Half With Ollas For more content like this visit REALfarmacy.com.

An Olla (pronounced oh-yah) is a handmade terracotta clay pot used by ancient cultures as a simple form of drip irrigation. Today it can be utilized for containers, raised beds, and ground applications alike. Sustainability enthusiasts have found attaching ollas to a rainwater collection system is very functional and effective. Research has found that they were []

Source: How to Cut Your Water Bill in Half With Ollas Learn more at REALfarmacy.com - Healthy News and Information.

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