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by Brian Shilhavy
Editor, Health Impact News
This past Friday (August 10, 2018) a jury in California awarded Dewayne Johnson, a former school groundskeeper who is dying of cancer that he claims is the result of years of using the herbicide RoundUp which contains glyphosate, $39 million in damages, and another $250 million was levied against Monsanto for covering up the scientific evidence that glyphosate causes cancer.
Here is a video of the verdict being read in court:
This is the first legal blow against Monsanto for its herbicide product, which is the worlds most common herbicide, spread on crops all over the world.
In recent years, laboratory testing on urine and mothers breast milk shows that almost the entire worlds population contains glyphosate in their bodies.
Health Impact News has covered this story for years now, and we published an interview with Dr. Anthony Samsel back in 2015, when he was able to obtain formerly concealed documents from the Environmental Protection Agency (EPA) revealing the toxic nature and cancer risk of the ingredients in the herbicide RoundUp, but were concealed from the public due to trade secrets. See:
Much of the pre-trial legal maneuvering was centered around what evidence was going to be allowed in the trial. In the end, in spite of what appeared to be at some points a biased judge, enough evidence was presented to the jury to conclude Monsanto was guilty.
While Monsanto is obvious...
Bernadette Pajer, co-president of Informed Choice Washington, made the most exceptional presentation before the Washington State Board of Health regarding fully informed medical consent and choice, full-disclosure regarding vaccine science and ingredients, plus Big Pharmas apparently illegal tactics that deprive citizens of their inherent and indisputable rights to self-determination regarding their health, their childrens health and vaccines/vaccinations.
Ms. Pajers presentation needs to be studied, and even replicated, regarding what her group found out about the modus operandi of Big Pharma and vaccine manufacturers to deny personal health rights and the obvious collusion that goes on between dozens of groups, if not hundreds, and that Big Pharma foots the bill.
If that is not collusion and something subject to legal action under the RICO and Sherman Anti-Trust laws of the United States, I dont know what is.
Brave Mom Exposes Vaccine Corruption To
Washington State Board of Health
Editors note: A list of warmlines, peer support groups, discussions about suicide and other resources can be found at the bottom of this post.
Not long ago, a friend of mine called the National Suicide Hotline. He was having a hard day and needed his distress to be heard. He barely got started talking before the operator interrupted him. It was the standard suicide assessment:
They also made clear that if he answered the questions a certain way, the 911 van would be dispatched to his residence forthwith.
Frankly, this is why I would never refer someone I loved to a suicide hotline. If I had any doubt about killing myself before calling, this kind of response would pretty much seal the deal. Theres the basic human insult of getting asked impersonal, pro forma questions like these in my darkest hour at my time of greatest need. Heap on top of that the public humiliation of getting hauled off to the nut ward by 911, flashing lights and all, for my neighborhood to see, on the worst day of my life.
Yes, not all hotlines and hotline operators are like this, but enough of them are that I, personally, wouldnt risk it. Suffice it to say: If I had any shred of a doubt remaining or perhaps a threadbare hope in the good of humanity this wholesale warping of the nature of human aid, sponsored by my government, funded with my tax dollars, would cut the cord once and for all between me and any lingering desire to live.
So whats the solution.? After all, this crisis is real. The pain is real. The despair is real. The deaths are real. Tons and tons of Americans as well as others worldwide feel hopeless, worthless, disconnected as if we have nothing of value to offer and our lives have only become burdens to those we love.
This really is life and death. So none of us can afford to stick our heads in the sand and pretend anymore: It isnt me. It isnt someone I love. It isnt happening
At the same time, the helplessness and confusion about what to do about it are also real.
And thats exactly why peer relationships and peer-developed modalities can be so helpful. Many, many of us have been there. Many, many of us know what it is like. Many, many of us are still alive to talk about it. We know what we tried, what worked for us and what didnt. We know what ways of relating gave us hope and helped us to continue on.
Just as important: we know what not to do, what devastated us, wasted precious resources or made life altogether unbearable. As a result of these experiences, weve developed countless...
4.6 European directive for the use of fluorides
The European Academy of Paediatric Dentistry (EAPD) recommends to everybody, including pregnant women, the preventive use of fluoride toothpaste as a primary preventive measure against caries (7). The most effective way to prevent dental caries is tooth brushing twice a day. Children should only spit out the toothpaste and not rinse with water afterwards.
Parents should start brushing childrens teeth with fluoride toothpaste as soon as the first tooth erupts in the concentration and quantity recommended by the EAPD (Table 2) (7). Parents should use the recommended amount of toothpaste and assist or supervise their children with tooth brushing at least up to the age of 7.
By Dr. Mercola
In this interview, Charlie Brown, founder of Consumers for Dental Choice, provides us with an update to the global mercury-free dentistry campaign you've so generously helped us support through the past eight years.
We are now incredibly close to the ultimate finish line, thanks to Brown's persistent and dedicated efforts and your unrelenting financial support. I want to extend a personal thank you to all who have contributed to this mission in the past, and are considering doing so now.
"We've been a great team since 2010," Brown says. "It's been fantastic. Without Mercola.com, we could not have built this world juggernaut, because that's where we are now in terms of our progress."
Topping our list of good news: Consumers for Dental Choice has successfully facilitated a total ban on dental amalgam for children under 15 and pregnant and nursing women within the European Union (EU), effective July 1, 2018 a victory that will positively affect half a billion people in 28 countries.
Edo, Nigeria, has also followed suit, as have the Bangladesh Dental Society (BDS), the Bangladesh Civil Society and the Vietnam Dental Society. In 2020, the EU will decide whether to take it a step further and phase out amalgam for all individuals across Europe. "Believe me, we're going to be there. When that question comes, there's only going to be one answer," Brown says.
Checks can also be mailed to:
Consumers for Dental Choice
316 F St., N.E., Suite 210
Washington DC 20002
In the U.S., Chicago has become a leading torch-bearer for mercury-free dentistry. "We decided Chicago was the right place. It's the city where so many ideas assembled," Brown says.
They began by getting a number of groups involved, including Sierra Club, Greenpeace, the Environmental Working Group, the Organic and Natural Health Association, the Learning Disabilities Association of America, Health Care Without Harm, the International Indian Treaty Council and the Mercury Policy Project.
By Dr. Mercola
Many struggle with obesity and a variety of chronic diseases. Although your food choices affect your health and how you feel today, tomorrow and in the future, rapid growth in the processed food industry has triggered an avalanche of weight gain, inflammation and chronic disease.
It might be difficult to imagine you could find nutritious and delicious meals that are easy to fix and satisfying to eat, but this is exactly what youll find in the Recipe section.
Although eating right is not an overnight fix for chronic health conditions, it is one of the most effective steps to help you achieve health independence. We have a diverse collection of mouth-watering and good-for-you recipes based on my optimized nutrition plan.
In the recipe section you'll find high-fiber meals to help control your blood sugar, support your immune system function, boost your weight loss and lower your risk of disease.
Satisfying salad recipes are a no-brainer as there are many choices to help you combine some of your favorite vegetables into one meal. Well give you suggestions to find organically grown fruits and vegetables and a variety of homemade salad dressing recipes so you control the types of seasonings and oils going into your blend.
Red meat is a main ingredient in dishes found around the globe because of its taste and versatility. What sets these recipes apart are the use of meat from organic, grass fed livestock combined with creative seasoning to make your whole family's mouths water.
If you thought you had to give up cookies or cocoa, think again. Our Nutty No-Bake Keto Cookie recipe and Creamy Keto Hot Cocoa recipe are a combination sure to satisfy your sweet tooth without the carbohydrates.
The Nutty No-Bake Keto Cookies take just 20 minutes to prepare, and even less time to eat. Instead of loading up on processed sweets and pastries, why not make your own using a recipe that doesn't even require your oven? The combination of macadamia nuts, pecans and grass fed butter make these cookies melt in your mouth.Nutty No-Bake Keto Cookies
Chocolate is a favorite treat for many. Cocoa is highly versatile and refers to roasted cacao or cocoa beans ground into a powder where most of...
As a trace element, fluoride can help ward off dental cavities. Exceptionally high pre- and postnatal exposures, as seen in populations whose drinking water supplies are contaminated by natural fluoride sources, have been implicated in a number of adverse health effects.1,2,3,4 However, less is known about fluorides neurotoxic risks at lower levels of exposure. A new study in Environmental Health Perspectives examines risks of exposure to prenatal fluoride at concentrations typical of the general population.5
In many countries, small amounts of fluoride are added to drinking water, salt, or milk to reduce the incidence of tooth decay.6,7,8 The U.S. Public Health Service recommends an optimal level of 0.7 mg/L fluoride in drinking water for caries prevention.2 Fluoride can also occur naturally in water, with concentrations exceeding 4.0 mg/L in some areas of the United States1; this is the maximum contaminant level for fluoride set by the U.S. Environmental Protection Agency.6
There is some debate regarding whether fluoridation is still needed for drinking water. Fluoridation of public water supplies was started in 1945 in the United States as a preventive measure to reduce the incidence of tooth decay.9 Most of the evidence for the benefits of fluoridation was collected prior to 1975, before widespread use of fluoride toothpastes and dental treatments1,9 and before modern assessments of dietary sources of fluoride....
PMID: Sports Med Open. 2017 Dec ;3(1):14. Epub 2017 Mar 28. PMID: 28349501 Abstract Title: A Placebo-Controlled Trial of Riboflavin for Enhancement of Ultramarathon Recovery. Abstract: BACKGROUND: Riboflavin is known to protect tissue from oxidative damage but, to our knowledge, has not been explored as a means to control exercise-related muscle soreness. This study investigated whether acute ingestion of riboflavin reduces muscle pain and soreness during and after completion of a 161-km ultramarathon and improves functional recovery after the event.METHODS: In this double-blind, placebo-controlled trial, participants of the 2016 161-km Western States Endurance Run were assigned to receive a riboflavin or placebo capsule shortly before the race start and when reaching 90 km. Capsules contained either 100 mg of riboflavin or 95 mg of maltodextrin and 5 mg of 10% -carotene. Subjects provided muscle pain and soreness ratings before, during, and immediately after the race and for the 10 subsequent days. Subjects also completed 400-m runs at maximum speed on days3, 5, and 10 after the race.RESULTS: For the 32 (18 in the riboflavin group, 14 in the placebo group) race finishers completing the study, muscle pain and soreness ratings during and immediately after the race were found to be significantly lower (p=.043) for the riboflavin group. Analysis of the 400-m run times also showed significantly faster (p
PMID: Molecules. 2016 Dec 15 ;21(12). Epub 2016 Dec 15. PMID: 27983705 Abstract Title: Riboflavin Reduces Pro-Inflammatory Activation of Adipocyte-Macrophage Co-culture. Potential Application of Vitamin B2 Enrichment for Attenuation of Insulin Resistance and Metabolic Syndrome Development. Abstract: Due to the progressive increase in the incidence of obese and overweight individuals, cardiometabolic syndrome has become a worldwide pandemic in recent years. Given the immunomodulatory properties of riboflavin, the current study was performed to investigate the potency of riboflavin in reducing obesity-related inflammation, which is the main cause of insulin resistance, diabetes mellitus 2 or arteriosclerosis. We determined whether pretreatment with a low dose of riboflavin (10.4-1000 nM) affected the pro-inflammatory activity of adipocyte-macrophage co-culture (3T3 L1-RAW 264.7) following lipopolysaccharide stimulation (LPS; 100 ng/mL) which mimics obesity-related inflammation. The apoptosis of adipocytes and macrophages as well as tumor necrosis factor-alpha (TNF-), interleukin 6 (IL-6), interleukin 1beta (IL-1), monocyte chemotactic protein 1 (MCP-1), high-mobility group box 1 (HMGB1), transforming growth factor-beta 1 (TGF), interleukin 10 (IL-10), inducible nitric oxide synthase (iNOS), nitric oxide (NO), matrix metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinases-1 (TIMP-1) expression and release, macrophage migration and adipokines (adiponectin and leptin) were determined. Our results indicated an efficient reduction in pro-inflammatory factors (TNF, IL-6, MCP-1, HMGB1) upon culture with riboflavin supplementation (500-1000nM), accompanied by elevation in anti-inflammatory adiponectin and IL-10. Moreover, macrophage migration was reduced by the attenuation of chemotactic MCP-1 release and degradation of the extracellular matrix by MMP-9. In conclusion, riboflavin effectively inhibits the pro-inflammatory activity of adipocyte and macrophage co-cultures, and therefore we can assume that its supplementation may reduce the likelihood of conditions associated with the mild inflammation linked to obesity.
PMID: Orphanet J Rare Dis. 2018 Jul 19 ;13(1):120. Epub 2018 Jul 19. PMID: 30025539 Abstract Title: Clinical, biochemical and genetic spectrum of 70 patients with ACAD9 deficiency: is riboflavin supplementation effective? Abstract: BACKGROUND: Mitochondrial acyl-CoA dehydrogenase family member 9 (ACAD9) is essential for the assembly of mitochondrial respiratory chain complex I. Disease causing biallelic variants in ACAD9 have been reported in individuals presenting with lactic acidosis and cardiomyopathy.RESULTS: We describe the genetic, clinical and biochemical findings in a cohort of 70 patients, of whom 29 previously unpublished. We found 34 known and 18 previously unreported variants in ACAD9. No patients harbored biallelic loss of function mutations, indicating that this combination is unlikely to be compatible with life. Causal pathogenic variants were distributed throughout the entire gene, and there was no obvious genotype-phenotype correlation. Most of the patients presented in the first year of life. For this subgroup the survival was poor (50% not surviving the first 2 years) comparing to patients with a later presentation (more than 90% surviving 10 years). The most common clinical findings were cardiomyopathy (85%), muscular weakness (75%) and exercise intolerance (72%). Interestingly, severe intellectual deficits were only reported in one patient and severe developmental delays in four patients. More than 70% of the patients were able to perform the same activities of daily living when compared to peers.CONCLUSIONS: Our data show that riboflavin treatment improves complex I activity in the majority of patient-derived fibroblasts tested. This effect was also reported for most of the treated patients and is mirrored in the survival data. In the patient group with disease-onset below 1 year of age, we observed a statistically-significant better survival for patients treated with riboflavin.
PMID: Curr Med Sci. 2018 Feb ;38(1):174-183. Epub 2018 Mar 15. PMID: 30074168 Abstract Title: B Vitamins Can Reduce Body Weight Gain by Increasing Metabolism-related Enzyme Activities in Rats Fed on a High-Fat Diet. Abstract: B vitamins are enzyme cofactors that play an important role in energy metabolism. The aim of this study was to elucidate whether B vitamin administration can reduce body weight (BW) gain by improving energy metabolism-related enzyme activities in rats fed on a highfat diet. Fifty rats were randomly assigned to one of the following five groups: control group (C), including rats fed on standard rat chow; four treatment groups (HO, HI, H2, and H3), in which rats were fed on a high-fat diet. Rats in the HI group were treated daily with 100 mg/kg BW thiamine (VB1), 100 mg/kg BW riboflavin (VB2), and 250 mg/kg BW niacin (VPP); rats in the H2 group were treated daily with 100 mg/kg BW pyridoxine (VB6), 100 mg/kg BW cobalamin (VB12), and 5 mg/kg BW folate (FA); and rats in the H3 group were treated daily with all of the B vitamins administered to the HI and H2 groups. After 12 weeks, the BW gains from the initial value were 154.558.4 g and 159.153.0 g in the HI and C groups, respectively, which were significantly less than the changes in the HO group (285.214.8 g, P
PMID: Ophthalmology. 2018 Aug ;125(8):1239-1250. Epub 2018 Jan 19. PMID: 29371008 Abstract Title: Myopia Prevention and Outdoor Light Intensity in a School-Based Cluster Randomized Trial. Abstract: PURPOSE: To investigate the effectiveness of a school-based program promoting outdoor activities in Taiwan for myopia prevention and to identify protective light intensities.DESIGN: Multi-area, cluster-randomized intervention controlled trial.PARTICIPANTS: A total 693 grade 1 schoolchildren in 16 schools participated. Two hundred sixty-seven schoolchildren were in the intervention group and 426 were in the control group.METHODS: Initially, 24 schools were randomized into the intervention and control groups, but 5 and 3 schools in the intervention and control groups, respectively, withdrew before enrollment. A school-based Recess Outside Classroom Trial was implemented in the intervention group, in which schoolchildren were encouraged to go outdoors for up to 11 hours weekly. Data collection included eye examinations, cycloplegic refraction, noncontact axial length measurements, light meter recorders, diary logs, and questionnaires.MAIN OUTCOME MEASURES: Change in spherical equivalent and axial length after 1 year and the intensity and duration of outdoor light exposures.RESULTS: The intervention group showed significantly less myopic shift and axial elongation compared with the control group (0.35 diopter [D] vs. 0.47 D; 0.28 vs. 0.33 mm; P = 0.002 and P = 0.003) and a 54% lower risk of rapid myopia progression (odds ratio, 0.46; 95% confidence interval [CI], 0.28-0.77; P = 0.003). The myopic protective effects were significant in both nonmyopic and myopic children compared with controls. Regarding spending outdoor time of at least11 hours weekly with exposure to 1000 lux or more of light, the intervention group had significantly more participants compared with the control group (49.79% vs. 22.73%; P
Understandably, it is not uncommon to find reference to arthritic changes, if for no other reason than the difficulty of distinguishing them from certain fluoride effects on bone.
Data are available from a single epidemiological study of gynecologic problems in female workers in a superphosphate manufacturing plant (Kuznetsova, 1969)[ref.99]. The exposed group comprised 302 women mostly 20-40 years old and the control group 309 office employees and housewives not exposed to F. Dust concentrations in the superphosphate plant ranged from 5 to 57 mg/m3; F concentrations ranged from about 0.3 to 2.8 mg/m3. Irregularities of menstruation were considerable more frequent (five or six times) in the workers; the frequency increased with dustiness, not with age, but markedly (two times) with employment over six years. Inflammation of the uterus, cervix and vagina occurred four times as frequently in workers, mostly in women exposed to plain and granulated superphosphate.
No differences were noted between exposed and control groups in the numbers or the courses of pregnancies, miscarriages, and births. During pregnancy, the plant workers more frequently showed (a) toxicosis with hypotension and threatened abortion, and (b) untimely discharge of amniotic fluid and weakness of birth activity [Kuznetsova LS s, Gig Tr i Prof Zabol 13:21-5,1969]. Additional epidemiological studies are needed.
PMID: EBioMedicine. 2017 Feb ;15:210-219. Epub 2016 Dec 16. PMID: 28063778 Abstract Title: Violet Light Exposure Can Be a Preventive Strategy Against Myopia Progression. Abstract: Prevalence of myopia is increasing worldwide. Outdoor activity is one of the most important environmental factors for myopia control. Here we show that violet light (VL, 360-400nm wavelength) suppresses myopia progression. First, we confirmed that VL suppressed the axial length (AL) elongation in the chick myopia model. Expression microarray analyses revealed that myopia suppressive gene EGR1 was upregulated by VL exposure. VL exposure induced significantly higher upregulation of EGR1 in chick chorioretinal tissues than blue light under the same conditions. Next, we conducted clinical research retrospectively to compare the AL elongation among myopic children who wore eyeglasses (VL blocked) and two types of contact lenses (partially VL blocked and VL transmitting). The data showed the VL transmitting contact lenses suppressed myopia progression most. These results suggest that VL is one of the important outdoor environmental factors for myopia control. Since VL is apt to be excluded from our modern society due to the excessive UV protection, VL exposure can be a preventive strategy against myopia progression.
PMID: Zhonghua Liu Xing Bing Xue Za Zhi. 2016 Nov 10 ;37(11):1555-1560. PMID: 28057151 Abstract Title: [Progress in research of association between myopia and sunlight exposure in children]. Abstract: Myopia has become a major health problem on global scale due to its increasing high prevalence in the past few decades and gradual younger onset age. Accumulated epidemiological surveys have shown that decreased time of exposure to sunlight would be an inducement for the development of myopia. Increasing time spent outdoors and exposure to sunlight might be the most cost-effective and effective measure for children to prevent myopia. This paper summarizes the progress in research of the association between sunlight exposure and myopia in children and its mechanisms to provide new clues for the research on myopia prevention and control.
PMID: J Clin Pharm Ther. 2017 Aug ;42(4):394-403. Epub 2017 May 8. PMID: 28485121 Abstract Title: Prophylaxis of migraine headaches with riboflavin: A systematic review. Abstract: WHAT IS KNOWN AND OBJECTIVE: Migraine headache is a relatively common, debilitating condition that costs our healthcare system over 78 billion dollars per year. Riboflavin has been advocated as a safe, effective prophylactic therapy for the prevention of migraines. The purpose of this study was to provide a systematic review of the current role of riboflavin in the prophylaxis of migraine headache.METHODS: A MEDLINE literature search inclusive of the dates 1966-2016 was performed using the search terms: riboflavin and migraine disorders. Excerpta Medica was searched from 1980 to 2016 using the search terms: riboflavin and migraine. Additionally, Web of Science was searched using the terms riboflavin and migraine inclusive of 1945-2016. Bibliographies of all relevant papers were reviewed for additional citations. We utilized the PRISMA guidelines to select English language, human, clinical trials of riboflavin as a single entity or in combination, review articles, and supporting pharmacokinetic and pharmacogenomic data assessing the efficacy and mechanism of riboflavin therapy in the prophylactic treatment of migraine headache.RESULTS AND DISCUSSION: A total of 11 clinical trials reveal a mixed effect of riboflavin in the prophylaxis of migraine headache. Five clinical trials show a consistent positive therapeutic effect in adults; four clinical trials show a mixed effect in paediatric and adolescent patients, and two clinical trials of combination therapy have not shown benefit. Adverse reactions with riboflavin have generally been mild.WHAT IS NEW AND CONCLUSION: Riboflavin is well tolerated, inexpensive and has demonstrated efficacy in the reduction of adult patient's migraine headache frequency. Additional data are needed, however, to resolve questions involving pharmacokinetic issues and pharmacogenomic implications of therapy.
PMID: Front Neurol. 2017 ;8:333. Epub 2017 Jul 20. PMID: 28775706 Abstract Title: Riboflavin Has Neuroprotective Potential: Focus on Parkinson's Disease and Migraine. Abstract: With the huge negative impact of neurological disorders on patient's life and society resources, the discovery of neuroprotective agents is critical and cost-effective. Neuroprotective agents can prevent and/or modify the course of neurological disorders. Despite being underestimated, riboflavin offers neuroprotective mechanisms. Significant pathogenesis-related mechanisms are shared by, but not restricted to, Parkinson's disease (PD) and migraine headache. Those pathogenesis-related mechanisms can be tackled through riboflavin proposed neuroprotective mechanisms. In fact, it has been found that riboflavin ameliorates oxidative stress, mitochondrial dysfunction, neuroinflammation, and glutamate excitotoxicity; all of which take part in the pathogenesis of PD, migraine headache, and other neurological disorders. In addition, riboflavin-dependent enzymes have essential roles in pyridoxine activation, tryptophan-kynurenine pathway, and homocysteine metabolism. Indeed, pyridoxal phosphate, the active form of pyridoxine, has been found to have independent neuroprotective potential. Also, the produced kynurenines influence glutamate receptors and its consequent excitotoxicity. In addition, methylenetetrahydrofolate reductase requires riboflavin to ensure normal folate cycle influencing the methylation cycle and consequently homocysteine levels which have its own negative neurovascular consequences if accumulated. In conclusion, riboflavin is a potential neuroprotective agent affecting a wide range of neurological disorders exemplified by PD, a disorder of neurodegeneration, and migraine headache, a disorder of pain. In this article, we will emphasize the role of riboflavin in neuroprotection elaborating on its proposed neuroprotective mechanisms in opposite to the pathogenesis-related mechanisms involved in two common neurological disorders, PD and migraine headache, as well as, we encourage the clinical evaluation of riboflavin in PD and migraine headache patients in the future.
Dane Wigington GeoengineeringWatch.org Our world is changing to a degree and at a rate that few yet understand. Wheels have been set in motion that can no longer be stopped. How will the masses react to what is unfolding? How long do we have until major links in the chain of our current reality begin to
PMID: Exp Eye Res. 2017 12 ;165:1-6. Epub 2017 Aug 31. PMID: 28864176 Abstract Title: Riboflavin and ultraviolet A irradiation for the prevention of progressive myopia in a guinea pig model. Abstract: In this study, we evaluated the effect of oral administration of riboflavin combined with whole-body ultraviolet A (UVA) irradiation on the biochemical and biomechanical properties of sclera in a guinea pig model to control the progression of myopia. Experimental groups were administered 0.1% riboflavin solution with or without vitamin C by gavage from 3 days before myopic modeling and during the modeling process. Guinea pigs underwent 30 min of whole-body UVA irradiation after each gavage for 2 weeks. For control groups, guinea pigs were administered vitamin C and underwent either whole-body UVA irradiation without 0.1% riboflavin solution or whole-body fluorescent lamp irradiation with or without 0.1% riboflavin solution. Resultantly, myopia models were established with an increased axial length and myopic diopter. Compared with myopic eyes in the control groups, the net increase in axial length, diopter and strain assessment decreased significantly, and the net decrease in sclera thickness, ultimate load, and stress assessment decreased significantly in experimental groups. MMP-2 expression showed a lower net increase, while TIMP-2 expression showed a lower net decrease. In addition, hyperplasia of scleral fibroblasts was more active in myopic eyes of experimental groups. Overall, our results showed that oral administration of riboflavin with whole-body UVA irradiation could increase the strength and stiffness of sclera by altering the biochemical and biomechanical properties, and decreases in axial elongation and myopic diopter are greater in the guinea pig myopic model.
PMID: PLoS One. 2015 ;10(6):e0127863. Epub 2015 Jun 1. PMID: 26030845 Abstract Title: Exposure to sunlight reduces the risk of myopia in rhesus monkeys. Abstract: Exposure to sunlight has recently been postulated as responsible for the effect that more time spent outdoors protects children from myopia, while early life exposure to natural light was reported to be possibly related to onset of myopia during childhood. In this study, we had two aims: to determine whether increasing natural light exposure has a protective effect on hyperopic defocus-induced myopia, and to observe whether early postnatal exposure to natural light causes increased risk of refractive error in adolescence. Eight rhesus monkeys (aged 20-30 days) were treated monocularly with hyperopic-defocus (-3.0D lens) and divided randomly into two groups: AL group (n=4), reared under Artificial (indoor) Lighting (08:00-20:00); and NL group (n=4), exposed to Natural (outdoor) Light for 3 hours per day (11:00-14:00), and to indoor lighting for the rest of the light phase. After being reared with lenses for ca. 190 days, all monkeys were returned to unrestricted vision until the age of 3 years. Another eight age-matched monkeys, reared with unrestricted vision under artificial lighting since birth, were employed as controls. The ocular refraction, corneal curvature and axial dimensions were measured before lens-wearing (at 233 days of age), monthly during the light phase, and at the age of puberty (at 1185+3 days of age). During the lens-wearing treatment, infant monkeys in the NL group were more hyperopic than those in the AL group (F=5.726, P=0.032). Furthermore, the two eyes of most NL monkeys remained isometropic,whereas 3 of 4 AL monkeys developed myopic anisometropia more than -2.0D. At adolescence, eyes of AL monkeys showed significant myopic anisometropia compared with eyes of NL monkeys (AL vs NL: -1.660.87D vs -0.220.44D; P=0.002) and controls (AL vs Control: -1.660.87D vs -0.050.85D; P
n/a PMID: Br J Ophthalmol. 2018 Jul 17. Epub 2018 Jul 17. PMID: 30018147 Abstract Title: Vitamin D and its pathway genes in myopia: systematic review and meta-analysis. Abstract: OBJECTIVE: To conduct a systematic review and meta-analysis of the association of blood vitamin D (25-hydroxyvitamin D, 25(OH)D) concentration and vitamin D pathway genes with myopia. METHODS: We searched the MEDLINE and EMBASE databases for studies published up to 29 January 2018. Cross-sectional or cohort studies which evaluated the blood 25(OH)D concentration, blood 25(OH)D3 concentration or vitamin D pathway genes, in relation to risk of myopia or refractive errors were included. Standard mean difference (SMD) of blood 25(OH)D concentrations between the myopia and non-myopia groups was calculated. The associations of blood 25(OH)D concentrations and polymorphisms in vitamin D pathway genes with myopia using summary ORs were evaluated. RESULTS: We summarised seven studies involving 25 008 individuals in the meta-analysis. The myopia group had lower 25(OH)D concentration than the non-myopia group (SMD=-0.27 nmol/L, p=0.001). In the full analysis, the risk of myopia was inversely associated with blood 25(OH)D concentration after adjusting for sunlight exposure or time spent outdoors (adjusted odds ratio (AOR)=0.92 per 10 nmol/L, p<0.0001). However, the association was not statistically significant for the<18 years subgroup (AOR=0.91 per 10 nmol/L, p=0.13) and was significant only for 25(OH)D3 (likely to be mainly sunlight derived), but not total 25(OH)D (AOR=0.93 per 10 nmol/L, p=0.00007; AOR=0.91 per 10 nmol/L, p=0.15). We analysed four single nucleotide polymorphisms in the VDR gene from two studies; there was no significant association with myopia. CONCLUSIONS: Lower 25(OH)D is associated with increased risk of myopia; the lack of a genetic association suggests that 25(OH)D level may be acting as a proxy for time outdoors.
PMID: Toxicol Lett. 2018 Jun 15. Epub 2018 Jun 15. PMID: 29908847 Abstract Title: A commercial Roundup formulation induced male germ cell apoptosis by promoting the expression of XAF1 in adult mice. Abstract: Roundup is extensively used for weed control worldwide. Residues of this compound may lead to side effects of the male reproductive system. However, the toxic effects and mechanisms of Roundup of male germ cells remain unclear. We aimed to investigate the apoptosis-inducing effects of Roundup on mouse male germ cells and explore the role of a novel tumor suppressor XAF1 (X-linked inhibitor of apoptosis-associated factor 1) involved in this process. We demonstrated that Roundup can impair spermatogenesis, decrease sperm motility and concentration, and increase the sperm deformity rate in mice.In addition, excessive apoptosis of germ cells accompanied by the overexpression of XAF1 occurred after Roundup exposure both in vitro and in vivo. Furthermore, the low expression of XIAP (X-linked inhibitor of apoptosis) induced by Roundup was inversely correlated with XAF1. Moreover, the knockdown of XAF1 attenuated germ cell apoptosis, improved XIAP expression and inhibited the activation of its downstream target proteins, caspase-3 and PARP, after Roundup exposure. Taken together, our data indicated that XAF1 plays an important role in Roundup-induced male germ cell apoptosis. Thepresent study suggested that Roundup exposure has potential negative implications on male reproductive health in mammals.
PMID: Food Chem Toxicol. 2018 Jul 25 ;120:510-522. Epub 2018 Jul 25. PMID: 30055318 Abstract Title: The mechanism of DNA damage induced by Roundup 360 PLUS, glyphosate and AMPA in human peripheral blood mononuclear cells - genotoxic risk assessement. Abstract: Glyphosate is the most heavily applied among pesticides in the world, and thus human exposure to this substance continues to increase. WHO changed classification of glyphosate to probably cancerogenic to humans, thus there is urgent need to assess in detail genotoxic mechanism of its action. We have assessed the effect of glyphosate, its formulation (Roundup 360 PLUS) and its main metabolite (aminomethylphosphonic acid, AMPA) in the concentration range from 1 to 1000M on DNA damage in human peripheral blood mononuclear cells (PBMCs). The cells were incubated for 24h. The compounds studied and formulation induced DNA single and double strand-breaks and caused purines and pyrimidines oxidation. None of compounds examined was capable of creating adducts with DNA, while those substances increased ROS (includingOH) level in PBMCs. Roundup 360 PLUS caused damage to DNA even at 5M, while glyphosate and particularly AMPA induced DNA lesions from the concentration of 250M and 500M, respectively. DNA damage induced by glyphosate and its derivatives increased in order: AMPA, glyphosate, Roundup 360 PLUS. We may conclude that observed changes were not associated with direct interaction of xenobiotics studied with DNA, but the most probably they occurred through ROS-mediated effects.
In dental caries prophylaxis in general, and especially in pregnant women, the use of a fluoride-containing mouthwash in the form of sodium or selenium fluoride (sodium or selenium 1-2%) is recommended along with a correct brushing technique. Fluoride-containing chewing gum is a pleasant vector, acting both locally and generally. It stimulates salivary secretion by increasing the interproximal flow. Chewing gum reduces food stores by about 80%, as well as microbial plaque. Varieties containing xylitol reduce the number of Streptococci mutans and also increase the pH of the mouth and bacterial plaque (7). Investigations, followed by appropriate instrumentation methods, are decisive to the preservation of dental structures. Introduction of fluoridated remineralizing substances contributes to the achievement of contemporary dentistry goals (8).
It has been observed that, at a relatively short time after conception, dentinal hyperesthesia occurs, especially in the cervical area of the teeth, at the erosion, wear or abrasion zones, being triggered by temperature change and sapids (sweet, sour). This is particularly noticeable in the first trimester of pregnancy as a result of vomiting and consumption of acidic foods.
For this reason, it is recommended to rinse ones mouth with mouthwash (Listerine) or 5% bicarbonate solution after each vomit or acidic food ingestion. Special protective shields (bite guard) can also be used along with a gel or fluoridated solutions (1).
A San Francisco jury returned a verdict in the case of a former groundskeeper with terminal cancer against Monsanto Company, ordering the agrochemical giant to pay $39.2 million in damages
By Anna Hunt
It has never been more challenging to disconnect from technology than it is today. In most homes, laptops, TVs and smartphones easily distract us, often sucking us into media time-warps. Research now shows that broadband Internet access is creating an environment that results in sleep deprivation.
Researchers at Bocconi University and University of Pittsburgh published a study that found temptations created by broadband Internet is a noteworthy cause of sleep deprivation. They linked data on broadband Internet rollout in Germany to surveys of individuals who reported sleep duration. They published the study in the Journal of Economic Behavior and Organization.
One of the main finding of this study showed that Internet access reduces both sleep duration and sleep satisfaction. This trend most significantly affects individuals who are rushed during the mornings because of work or family responsibilities.
Francesco Billari, a Full Professor of Demography at Bocconi University, Milan, and the Principal Investigator of the project DisCont, stated:
Individuals with DSL access tend to sleep 25 minutes less than their counterparts without DSL Internet. They are significantl...
On August 11th, 2014, a dark cloud descended: Robin Williams, the man who had brought joy into millions of homes the world over, was pronounced dead. He had taken his own life. Countless people took to social media to express their profound sadness and loss; in his tribute to the fallen actor and stand-up comedian, former U.S. president Barack Obama encapsulated Americas collective grief as follows:1
He was an airman, a doctor, a genie, a nanny, a president, a professor, a bangarang Peter Pan, and everything in between. But he was one of a kind. He arrived in our lives as an alien but he ended up touching every element of the human spirit. He made us laugh. He made us cry. He gave his immeasurable talent freely and generously to those who needed it most from our troops stationed abroad to the marginalized on our own streets.
Making his debut on the hit TV sitcom Mork & Mindy (1978-1982) as an alien from planet Ork, Williams would go on to perform in the big screen in a number of starring rolesfrom radio disc jockey Adrian Cronauer in Good Morning Vietnam (1987), to the gender-bending Daniel Hillard/Euphegenia Doubtfire of Mrs. Doubtfire (1993) fame, to widower and psychotherapist Sean Maguire in Good Will Hunting (1997), for which he won an Oscar for Best Supporting Actor.
As his decades-long career illustrates, Williamss acting possessed both breadth and depth. He was capable of inhabiting a multitude of roles, and through his embodiment of those roles eliciting a range of emotions from viewers. One moment, as the Genie of Alladin (1992), he provokes uncontrollable laughter with his wild voice impersonation of fifty-two distinct characters. The next moment, he elicits both fear and pity as a lonely photo technician whose obsession with a particular family takes a decidedly dangerous turn (One Hour Photo, 2002). Williams had the ability to go from manic to mad to tender and vulnerable, and so immersed was he in his roles that during the filming of Mrs. Doubtfire, members of the public, and the cast and crew, treated him as if he really were an old lady.
But as Obamas tribute makes clear, the world did not only lose a talent; it lost a kindred spirit. Robin Williams was not only a good actor but a good human being. When Christopher Reeves of Superman fame was in the hospital following the tragic horseback-riding accident that rendered him quadriplegic, Williams, in full regalia, arrived as a Russian proctologist, bringing laughter back into his best friends life. Similarly, when Steven Spielberg fell into a deep depression during the filming of Schindlers List, Williams spent countless nights on the...
Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured the departure of a professor in Glasgow amidst three retraction; Continue reading Weekend reads: Why rhetoric and self-censorship is bad for science; an author threatens to sue his critics; why whistleblowing is critical
The science has never been clearer: flaxseed deserves to be top of the list of the world's most important medicinal foods. For just pennies a day it may protect against dozens of life-threatening health conditions.
From St. Louis Public Radio: A study from the Journal of Mental Health Counselling found that 81 percent of the African-Americans who reported racial discrimination were more likely to experience symptoms of PTSD.
Leon Sharpe, a human and organizational development specialist, agreed that trauma can have a powerful impact, especially when linked to racial profiling. He warned that the effects can be passed down through families.
Theres also the generational trauma that gets handed down from one generation to another in communities of color around experiencing racism, Sharpe said. There needs to be continued work to address that.'
PMID: Phytomedicine. 2013 Jul 15 ;20(10):775-9. Epub 2013 Apr 30. PMID: 23643094 Abstract Title: Nordihydroguaiaretic acid induces Nrf2 nuclear translocation in vivo and attenuates renal damage and apoptosis in the ischemia and reperfusion model. Abstract: It has been shown that the pretreatment with nordihydroguaiaretic acid (NDGA), a lignan with direct and indirect antioxidant properties, protects against the ischemia-reperfusion (I/R)-induced renal oxidant damage. Although it has been shown that NDGA induces Nrf2 nuclear translocation in renal epithelial LLC-PK1 cells in culture, it is unknown if NDGA may induce Nrf2 translocation in vivo. In this work was explored if NDGA is able to induce in vivo Nrf2 nuclear translocation in kidneys of rats submitted to uni-nephrectomy (U-NX) or I/R injury. Four groups of male Wistar rats were used: U-NX, NDGA, I/R, and I/R+NDGA. NDGA was injected i.p. (10mg/kg/day) starting 48 h before I/R. Kidney samples were obtained at 3 h of reperfusion after to measure Nrf2 translocation. Additional groups of rats were studied at 24 h of reperfusion to measure histological damage and apoptosis. NDGA was able to induce Nrf2 translocation in vivo in kidneys of rats submitted to both U-NX and I/R injury and to protect against renal histological damage and apoptosis. It is concluded that the pretreatment of NDGA is able to induce in vivo nuclear Nrf2 translocation in kidney of rats suggesting that this may be involved in the renoprotection against I/R.
n/a PMID: Biomed Res Int. 2015 ;2015:734548. Epub 2015 Apr 6. PMID: 25945343 Abstract Title: Nordihydroguaiaretic Acid Disrupts the Antioxidant Ability of Helicobacter pylori through the Repression of SodB Activity In Vitro. Abstract: Iron-cofactored superoxide dismutase (SodB) of Helicobacter pylori plays an indispensable role in the bacterium's colonization of the stomach. Previously, we demonstrated that FecA1, a Fe(3+)-dicitrate transporter homolog, contributes to SodB activation by supplying ferrous iron (Fe(2+)) to SodB, and fecA1-deletion mutant strains have reduced gastric mucosal-colonization ability in Mongolian gerbils, suggesting that FecA1 is a possible target for the development of a novel eradication therapy. This study aimed to identify novel FecA1-binding compounds in silico and then examined the effect of a predicted FecA1-binding compound on H. pylori SodB activity in vitro. Specifically, we demonstrated that nordihydroguaiaretic acid (NDGA) is a predicted FecA1-binding compound. NDGA reduced intracellular Fe(2+) levels in H. pylori and reduced SodB activity. Additionally, NDGA increased H2O2 sensitivity of H. pylori and increased the metronidazole (Mtz) sensitivity. The present study demonstrated that NDGA repressed SodB activity associated with the gastric mucosal-colonization via inhibition of intracellular Fe(2+) uptake by FecA1, suggesting that NDGA might be effective for the development of a novel eradication therapy.
Steve Jobs, the Apple CEO, was a very skilled and successful businessman who passed away in 2011 from cancer. For most people, thats about the extent of whats known about him. But, as with everyone, there is much more to a person than just the basic trivia answers or top google searches. Steve Jobs daughter,... View Article
What if you could replace the gym with a glass of wine? While I dont want to encourage you to skip the gym, this may actually be possible according to new research. What Wine Can Do For Your Body Scientists headed by Jason Dyck from the University of Alberta have found that a compound in... View Article
The post New Research Says One Glass Of Red Wine Can Replace An Hour Of Exercise appeared first on Healthy Holistic Living.
PMID: Int Immunopharmacol. 2015 Sep ;28(1):634-42. Epub 2015 Aug 3. PMID: 26247680 Abstract Title: Nordihydroguaiaretic acid ameliorates cisplatin induced nephrotoxicity and potentiates its anti-tumor activity in DMBA induced breast cancer in female Sprague-Dawley rats. Abstract: Cisplatin is a widely used antineoplastic drug, but its clinical usefulness is limited due to dose dependent nephrotoxicity. Nordihydroguaiaretic acid (NDGA) is a natural compound with broad pharmacological properties like antioxidant, anti-inflammatory and anticancer activity. The present study was undertaken to evaluate the possible beneficial effects of NDGA on cisplatin induced nephrotoxicity as well as its anticancer activity in rats bearing DMBA induced mammary tumors. The effect of NDGA on cisplatin induced nephrotoxicity was evaluated by checking serum nephrotoxicity markers, antioxidant enzymes and inflammatory markers level and kidney histopathology. NDGA induced amelioration of cisplatin nephrotoxicity was clearly visible from significant reductions in serum blood urea nitrogen (86.51 g/dl) and creatinine (5.30 g/dl) levels and significant improvement in body weight change (-10.34 g) and kidney weight (728 mg/kg). The protective effect of NDGA against cisplatin induced nephrotoxicity in the rats was further confirmed by significant restoration of antioxidant enzymes like SOD (86.28% inhibition), inflammatory markers like TNF- (34.6 pg/ml) and histopathological examination. Moreover, our results showed that NDGA potentiated anti-breast cancer activity of cisplatin through an increment in the expression of antioxidant enzymes like SOD (85.35% inhibition) in breast cancer tissue. These results indicated that NDGA potentiated the anti-breast cancer activity of cisplatin, which was clearly evident from the tumor volume and % tumor inhibition in breast cancer rats. The current study demonstrated that NDGA may modify the therapeutic effect of cisplatin in DMBA induced breast cancer in female Sprague-Dawley rats.
By Dr. Mercola
Have you ever wondered how much vitamin C is in a serving of strawberries or what makes avocados so good for you? Or maybe you're interested to know which has more sugar: raisins or dates? It's questions like these that necessitated the creation of Mercola.com Food Facts.
Nutrition is key to staying healthy and avoiding chronic diseases. That's why I recommend virtually anyone starting out on the path to optimal wellness to adopt my nutrition plan. The plan provides a guide to changing your diet and lifestyle for the better, and it goes hand-in-hand with our Food Facts resource.
Now, when you add fresh vegetable juice to your diet, for instance, you can look up each ingredient and find out how its components, from vitamins and minerals to antioxidants and other phytochemicals, help keep you well.
Did you know, for instance, that blackberries contain impressively high levels of antioxidants or that the leaves and roots of eggplant have been used traditionally to treat stomach troubles and foot pain? This is just a sampling of the valuable information available at your fingertips via Food Facts. You'll also:
Discover nutrition facts, interesting trivia, uses around the world and important scientific studies about the healthy foods you consume
Gain access to a wealth of delicious, healthy recipes that will surely fit your holistic meal plans
Debunk common foods myths and misconceptions
Find out where to shop for safe, naturally healthy foods
Learn how consuming wholesome, healthy foods can help you stave off diseases and other common health problems
One of our most popular articles is "The 9 Foods You Should Never Eat," so clearly many people are interested in eating right. However, m...
By Dr. Mercola
This website was created 21 years ago, in 1997, when I combined my two primary passions in life health and technology and made it my mission to share exciting new developments in natural health with a wider audience.
Thanks to you, this site has become one of the most visited natural health websites in the world for the last 12 years, with more than 10 million unique visitors each month and more than 80 million unique visitors annually.
Because of your loyal support, we've slowly but surely awakened the world to the false promises of the fatally flawed conventional medical view, which claims disease is best treated with drugs, and that the government knows what's best for your health and should be allowed to dictate your health options.
In the video above, I discuss my own journey toward health, which ultimately led me to my present-day philosophies and recommendations.
This video and article were initially published during three years ago during anniversary week. It was a big hit, and since we've had a significant influx of new subscribers since then, I'm rerunning it for those who missed it.
Experience is a formidable teacher, and much of what I'm teaching today grew out of the lessons I learned as I tried to get healthier. I made plenty of mistakes, and fell for many of the lies, deceptions and confusion of conventional medicine.
Like so many others, I grew up eating cereal for breakfast, and I fully believed margarine was healthy. My diet was high in carbs and sugars and low in fat, and there's little doubt this played a significant role in dental decay, which I struggled with throughout a large portion of my life.
By the time I was an adult, I had a mouth full of amalgam fillings. Eventually, I discovered the truth about amalgam that it's actually 50 percent mercury and in 2009 I approached Charlie Brown (president of the Alliance for Mercury Free Dentistry) at a Health Freedom Expo in Chicago.
At that event, I offered to partner with him to raise awareness about mercury in dentistry and to help get this toxin out of dentistry for good.
It's been a highly successful partnership, and on October 10, 2013, a legally binding international treaty to control the use of this toxic metal was signed into action, thanks largely to the work of the Campaign for Mercury-Free Dentistry, the project organized and led by Charlie Brown.
The treaty, named the United Nations Minamata Convention on Mercury, requires the phasing out of many mercury-containing products by 2020. Importantly, the treaty mar...
PMID: Front Microbiol. 2015 ;6:1195. Epub 2015 Oct 27. PMID: 26579101 Abstract Title: Nordihydroguaiaretic acid enhances the activities of aminoglycosides against methicillin- sensitive and resistant Staphylococcus aureus in vitro and in vivo. Abstract: Infections caused by methicillin-sensitive Staphylococcus aureus (MSSA) and methicillin-resistant S. aureus (MRSA) are prevalent. MRSA infections are difficult to treat and there are no new classes of antibiotics produced to the market to treat infections caused by the resistant bacteria. Therefore, using antibiotic enhancers to rescue existing classes of antibiotics is an attractive strategy. Nordihydroguaiaretic acid (NDGA) is an antioxidant compound found in extracts from plant Larrea Tridentata. It exhibits antimicrobial activity and may target bacterial cell membrane. Combination efficacies of NDGA with many classes of antibiotics were examined by chequerboard method against 200 clinical isolates of MRSA and MSSA. NDGA in combination with gentamicin, neomycin, and tobramycin was examined by time-kill assays. The synergistic combinations of NDGA and aminoglycosides were tested in vivo using a murine skin infection model. Calculations of the fractional inhibitory concentration index (FICI) showed that NDGA when combined with gentamicin, neomycin, or tobramycin displayed synergistic activities in more than 97% of MSSA and MRSA, respectively. Time kill analysis demonstrated that NDGA significantly augmented the activities of these aminoglycosides against MRSA and MSSA in vitro and in murine skin infection model. The enhanced activity of NDGA resides on its ability to damage bacterial cell membrane leading to accumulation of the antibiotics inside bacterial cells. We demonstrated that NDGA strongly revived the therapeutic potencies of aminoglycosides in vitro and in vivo. This combinational strategy could contribute major clinical implications to treat antibiotic resistant bacterial infections.
PMID: Int Immunopharmacol. 2016 Feb ;31:149-57. Epub 2015 Dec 29. PMID: 26735610 Abstract Title: Nordihydroguaiaretic acid (NDGA) and-mangostin inhibit the growth of Mycobacterium tuberculosis by inducing autophagy. Abstract: Tuberculosis (TB) remains as a global health problem. The prevalence of this infection is related to the association with other diseases, such as HIV, neglect treatment and misuse of antibiotics. Hence, the identification of new drugs is required to eradicate TB. Possible alternatives to existing antibiotics include pure compounds extracted from medicinal plants, which are an important source of antimicrobial agents. The aim of this study was to evaluate the effect of nordihydroguaiaretic acid (NDGA) and-mangostin on Mycobacterium tuberculosis growth and bacterial survival in infected macrophages derived from the human THP-1 cell line and monocytes. Our results show that both compounds directly inhibit M. tuberculosis growth in liquid medium with Minimal Inhibitory Concentrations (MIC) of 250 and62 g/mL respectively, likely through preventing bacterial replication. In addition, NDGA and -mangostin were able to induce autophagy in human cells at lower concentrations (7 and 6 g/mL, respectively) and contributed to the elimination of intracellular bacteria. NDGA and -mangostin could be candidates for coadjuvant therapy in cases of drug-resistant TB, and their ability to enhance the immune response by promoting autophagy might contribute to TB treatment.
PMID: FEBS Open Bio. 2016 Oct ;6(10):1000-1007. Epub 2016 Aug 23. PMID: 27761359 Abstract Title: Effect of nordihydroguaiaretic acid on cell viability and glucose transport in human leukemic cell lines. Abstract: The polyphenol nordihydroguaiaretic acid (NDGA) has antineoplastic properties, hence it is critical to understand its action at the molecular level. Here, we establish that NDGA inhibits glucose uptake and cell viability in leukemic HL-60 and U-937 cell lines. We monitored hexose uptake using radio-labeled 2-deoxyglucose (2DG) and found that the inhibition by NDGA followed a noncompetitive mechanism. In addition, NDGA blocked hexose transport in human red blood cells and displaced prebound cytochalasin B from erythrocyte ghosts, suggesting a direct interaction with the glucose transporter GLUT1. We propose a model for the mechanism of action of NDGA on glucose uptake. Our study shows for the first time that NDGA can act as inhibitor of the glucose transporter GLUT1.
PMID: Oncotarget. 2016 Dec 27 ;7(52):86225-86238. PMID: 27863391 Abstract Title: Nordihydroguaiaretic acid impairs prostate cancer cell migration and tumor metastasis by suppressing neuropilin 1. Abstract: Tumor metastasis is a major cause leading to the deaths of cancer patients. Nordihydroguaiaretic acid (NDGA) is a natural product that has been demonstrated to show therapeutic values in multiple diseases. In this study, we report that NDGA can inhibit cell migration and tumor metastasis via a novel mechanism. NDGA suppresses NRP1 function by downregulating its expression, which leads to attenuated cell motility, cell adhesion to ECM and FAK signaling in cancer cells. Moreover, due to its cross-cell type activity on NRP1 suppression, NDGA also impairs angiogenesis function of endothelial cells and fibronectin assembly by fibroblasts, both of which are critical to promote metastasis. Based on these comprehensive effects, NDGA effectively suppresses tumor metastasis in nude mice model. Our findings reveal a novel mechanism underlying the anti-metastasis function of NDGA and indicate the potential value of NDGA in NRP1 targeting therapy for selected subtypes of cancer.
PMID: Antimicrob Agents Chemother. 2017 08 ;61(8). Epub 2017 Jul 25. PMID: 28507114 Abstract Title: Antiviral Activity of Nordihydroguaiaretic Acid and Its Derivative Tetra--Methyl Nordihydroguaiaretic Acid against West Nile Virus and Zika Virus. Abstract: Flaviviruses are positive-strand RNA viruses distributed all over the world that infect millions of people every year and for which no specific antiviral agents have been approved. These viruses include the mosquito-borne West Nile virus (WNV), which is responsible for outbreaks of meningitis and encephalitis. Considering that nordihydroguaiaretic acid (NDGA) has been previously shown to inhibit the multiplication of the related dengue virus and hepatitis C virus, we have evaluated the effect of NDGA, and its methylated derivative tetra--methyl nordihydroguaiaretic acid (MN), on the infection of WNV. Both compounds inhibited the infection of WNV, likely by impairing viral replication. Since flavivirus multiplication is highly dependent on host cell lipid metabolism, the antiviral effect of NDGA has been previously related to its ability to disturb the lipid metabolism, probably by interfering with the sterol regulatory element-binding proteins (SREBP) pathway. Remarkably, we observed that other structurally unrelated inhibitors of the SREBP pathway, such as PF-429242 and fatostatin, also reduced WNV multiplication, supporting that the SREBP pathway may constitute a druggable target suitable for antiviral intervention against flavivirus infection. Moreover, treatment with NDGA, MN, PF-429242, and fatostatin also inhibited the multiplication of the mosquito-borne flavivirus Zika virus (ZIKV), which has been recently associated with birth defects (microcephaly) and neurological disorders. Our results point to SREBP inhibitors, such as NDGA and MN, as potential candidates for further antiviral development against medically relevant flaviviruses.
PMID: Bull Exp Biol Med. 2017 Jul ;163(3):330-333. Epub 2017 Jul 26. PMID: 28744653 Abstract Title: Lipoxygenase Inhibitors Nordihydroguaiaretic Acid and Fungus Lecanicillum lecanii Extract Induce Death of Lymphoid Leukemia Cells. Abstract: We studied the effect of lipoxygenase inhibitors nordihydroguaiaretic acid (NDGA) and fungus Lecanicillum lecanii extract on lymphatic leukemia P388 cells. The cells grown in the abdominal cavity of DBA2 mice for 7 days were transferred into a nutrient medium. The effect of lipoxygenase inhibitors was evaluated by changes in cell number, trypan blue staining, nucleus damage, and changes in cell distribution by DNA content after 22-h incubation. NDGA and fungus extract induced apoptotic death of lymphatic leukemia cells, which was seen from nucleus damage and reduced DNA content in cells. ICfor NDGA and fungus extract was 0.66 and 5.5g/ml, respectively.
PMID: J Pharmacol Exp Ther. 2018 May ;365(2):281-290. Epub 2018 Feb 22. PMID: 29472517 Abstract Title: Nordihydroguaiaretic Acid, a Lignan from(Creosote Bush), Protects Against American Lifestyle-Induced Obesity Syndrome Diet-Induced Metabolic Dysfunction in Mice. Abstract: To determine the effects of nordihydroguaiaretic acid (NDGA) on metabolic and molecular changes in response to feeding a typical American fast food or Western diet, mice were fed an American lifestyle-induced obesity syndrome (ALIOS) diet and subjected to metabolic analysis. Male C57BL/6J mice were randomly assigned to the ALIOS diet, the ALIOS diet supplemented with NDGA (NDGA+ALIOS), or a control diet and were maintained on the specific diet for 8 weeks. Mice fed the ALIOS diet showed increased body, liver, and epididymal fat pad weight as well as increased plasma alanine transaminase (ALT) and aspartate aminotransferase (AST) levels (a measure of liver injury) and liver triglyceride content. Coadministration of NDGA normalized body and epididymal fat pad weight, ALT and AST levels, and liver triglycerides. NDGA treatment also improved insulin sensitivity but not glucose intolerance in mice fed the ALIOS diet. In mice fed the NDGA+ALIOS diet, NDGA supplementation induced peroxisome proliferator-activated receptor(PPAR; the master regulator of fatty acid oxidation) and mRNA levels of carnitine palmitoyltransferasesand, key genes involved in fatty acid oxidation, compared with the ALIOS diet. NDGA significantly reduced liver endoplasmic reticulum (ER) stress response C/EBP homologous protein, compared with chow or the ALIOS diet, and also ameliorated ALIOS diet-induced elevation of apoptosis signaling protein, caspase 3. Likewise, NDGA downregulated the ALIOS diet-induced mRNA levels of, fatty acid synthase, and diacylglycerol acyltransferaseNDGA treatment of ALIOS-fed mice upregulated the hepatic expression of antioxidant enzymes, glutathione peroxidase 4, and peroxiredoxin 3 proteins. In conclusion, we provide evidence that NDGA improves metabolic dysregulation by simultaneously modulating the PPARtranscription factor and key genes involved in fatty acid oxidation, key antioxidant and lipogenic enzymes, and apoptosis and ER stress signaling pathways.
PMID: IUBMB Life. 2018 May ;70(5):432-436. Epub 2018 Apr 10. PMID: 29637686 Abstract Title: Nordihydroguaiaretic acid can suppress progression of experimental autoimmune encephalomyelitis. Abstract: Multiple sclerosis (MS) is a poorly understood disease mechanistically. MOG35-55 peptide induced experimental autoimmune encephalomyelitis (EAE) is a broadly used model to study MS. Using this model we have earlier shown that the antioxidant tempol or the small molecule inhibitor of p38 SB203580 can effectively prevent EAE progression. This effect was mediated by means of regulating immune inflammation, signaling by the p38MAPK-SGK1 pathway, and oxidative stress. However, there is a need to test drugs that can be used in pharmacological intervention of EAE. Given that nordihydroguaiaretic Acid (NDGA) has been shown to possess anti-oxidant activity and capacity of antagonizing autoimmune inflammation, we tested the effect of NDGA in ameliorating EAE in the current study. NDGA showed significant beneficial effect against EAE with both anti-inflammation and antioxidant activity. NDGA could weaken the immune inflammation at least partly by inhibiting the oxidant stress-p38MAPK-SGK1 pathway representing a target for putative pharmacological intervention. 2018 IUBMB Life, 70(5):432-436, 2018.
PMID: Neoplasia. 2007 Nov ;9(11):893-9. PMID: 18030357 Abstract Title: Regulation of Cox-2 by cyclic AMP response element binding protein in prostate cancer: potential role for nexrutine. Abstract: We recently showed that Nexrutine, a Phellodendron amurense bark extract, suppresses proliferation of prostate cancer cell lines and tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model. Our data also indicate that the anti-proliferative effects of Nexrutine are emediated in part by Akt and Cyclic AMP response element binding protein (CREB). Cyclooxygenase (Cox-2), a pro-inflammatory mediator, is a CREB target that induces prostaglandin E(2) (PGE(2)) and suppresses apoptosis. Treatment of LNCaP cells with Nexrutine reduced tumor necrosis factor alpha-induced enzymatic as well as promoter activities of Cox-2. Nexrutine also reduced the expression and promoter activity of Cox-2 in PC-3 cells that express high constitutive levels of Cox-2. Deletion analysis coupled with mutational analysis of the Cox-2 promoter identified CRE as being sufficient for mediating Nexrutine response. Immunohistochemical analysis of human prostate tumors show increased expression of CREB and DNA binding activity in high-grade tumors (three-fold higher in human prostate tumors compared to normal prostate; P = .01). We have identified CREB-mediated activation of Cox-2 as a potential signaling pathway in prostate cancer which can be blocked with a nontoxic, cost-effective dietary supplement like Nexrutine, demonstrating a prospective for development of Nexrutine for prostate cancer management.
PMID: Clin Cancer Res. 2014 Mar 1 ;20(5):1259-73. Epub 2014 Feb 11. PMID: 24520096 Abstract Title: Combined targeting of STAT3/NF-B/COX-2/EP4 for effective management of pancreatic cancer. Abstract: PURPOSE: Near equal rates of incidence and mortality emphasize the need for novel targeted approaches for better management of patients with pancreatic cancer. Inflammatory molecules NF-B and STAT3 are overexpressed in pancreatic tumors. Inhibition of one protein allows cancer cells to survive using the other. The goal of this study is to determine whether targeting STAT3/NF-B crosstalk with a natural product Nexrutine can inhibit inflammatory signaling in pancreatic cancer.EXPERIMENTAL DESIGN: HPNE, HPNE-Ras, BxPC3, Capan-2, MIA PaCa-2, and AsPC-1 cells were tested for growth, apoptosis, cyclooxygenase-2 (COX-2), NF-B, and STAT3 level in response to Nexrutine treatment. Transient expression, gel shift, chromatin immunoprecipitation assay was used to examine transcriptional regulation of COX-2. STAT3 knockdown was used to decipher STAT3/NF-B crosstalk. Histopathologic and immunoblotting evaluation was performed on BK5-COX-2 transgenic mice treated with Nexrutine. In vivo expression of prostaglandin receptor E-prostanoid 4 (EP4) was analyzed in a retrospective cohort of pancreatic tumors using a tissue microarray.RESULTS: Nexrutine treatment inhibited growth of pancreatic cancer cells through induction of apoptosis. Reduced levels and activity of STAT3, NF-B, and their crosstalk led to transcriptional suppression of COX-2 and subsequent decreased levels of prostaglandin E2 (PGE2) and PGF2. STAT3 knockdown studies suggest STAT3 as negative regulator of NF-B activation. Nexrutine intervention reduced the levels of NF-B, STAT3, and fibrosis in vivo. Expression of prostaglandin receptor EP4 that is known to play a role in fibrosis was significantly elevated in human pancreatic tumors.CONCLUSIONS: Dual inhibition of STAT3-NF-B by Nexrutine may overcome problems associated with inhibition of either pathway.
PMID: Oncotarget. 2014 May 15 ;5(9):2529-41. PMID: 24796733 Abstract Title: STAT3 down regulates LC3 to inhibit autophagy and pancreatic cancer cell growth. Abstract: The dismal 5-year survival (
PMID: Toxicol Rep. 2015 ;2:1-11. Epub 2014 Nov 13. PMID: 28962332 Abstract Title: Dietary administration of Nexrutine inhibits rat liver tumorigenesis and induces apoptotic cell death in human hepatocellular carcinoma cells. Abstract: Epidemiological studies suggested that plant-based dietary supplements can reduce the risk of liver cancer. Nexrutine (NX), an herbal extract from, has been shown to have anti-inflammatory, anti-microbial and anti-tumor activities. In the present study, we have shown the anti-tumor potential of NX against Solt-Farber model with elimination of PH, rat liver tumor induced by diethylnitrosoamine (DEN) as carcinogen and 2-acetylaminofluorene (2-AAF) as co-carcinogen. The elucidation of mechanistic pathways was explored in human liver cancer cells. Dietary intake of NX significantly decreased the cell proliferation and inflammation, as well as increased apoptosis in the liver sections of DEN/2-AAF-treated rats. Moreover, NX (2.5-10 g/ml) exposure significantly decreased the viability of liver cancer cells and modulated the levels of Bax and Bcl-2 proteins levels. NX treatment resulted in increased cytochrome-release and cleavage of caspases 3 and 9. In addition, NX decreased the expression of CDK2, CDK4 and associated cyclins E1 and D1, while up-regulated the expression of p21, p27 and p53 expression. NX also enhanced phosphorylation of the mitogen-activated protein kinases (MAPKs) ERK1/2, p38 and JNK1/2. Collectively, these findings suggested that NX-mediated protection against DEN/2-AAF-induced liver tumorigenesis involves decrease in cell proliferation and enhancement in apoptotic cell death of liver cancer cells.
PMID: Photodermatol Photoimmunol Photomed. 2018 Jan ;34(1):82-90. Epub 2017 Oct 9. PMID: 28857273 Abstract Title: Topical application of Nexrutine inhibits ultraviolet B-induced cutaneous inflammatory responses in SKH-1 hairless mouse. Abstract: BACKGROUND: Ultraviolet B (UVB) radiation is the major contributor to skin inflammation which leads to the development of skin cancer. Hence, in this study, we studied the effect of Nexrutine (NX) on UVB-induced cutaneous inflammation and its mediators.METHODS: Ultraviolet absorption spectra of NX were measured by spectrophotometer. To conduct the photoprotective studies, SKH-1 hairless mice were topically treated with NX, 30 minutes before to the UVB (180 mJ/cm) exposure. Twenty hours of post-UVB irradiation, mouse skin was used for edema measurements, H&E staining, myeloperoxidase (MPO) activity, and estimation of plasma cytokines. In addition, expression levels of inflammatory cytokines, cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) were also determined by Western blot analysis.RESULTS: Nexrutine displayed absorbance over the UVB spectrum. NX significantly decreased the UVB-induced epidermal edema, skin thickness, leukocyte infiltration, number of the sunburn, and TUNEL-positive cells. NX treatment also decreased the number of mast cells, MPO activity, expression of pro-inflammatory cytokines, and inflammation mediator protein in mouse skin.CONCLUSION: These results provide evidences that NX inhibits the UVB-induced cutaneous inflammatory responses in SKH-1 mouse skin.
PMID: Cancer Lett. 2018 Oct 1 ;433:232-241. Epub 2018 Jul 9. PMID: 30003927 Abstract Title: Suppression of ribosomal protein RPS6KB1 by Nexrutine increases sensitivity of prostate tumors to radiation. Abstract: Radiation therapy (XRT) is a standard treatment for prostate cancer (PCa). Although dose escalation increases local control, toxicity hampers further escalation. Broader improvement will be possible by the addition of adjuvant therapies, which can synergize with radiation and thus improve efficacy. We have identified a natural compound (Nexrutine, Nx) that inhibits the survival and growth of PCa cells in combination with radiation. Combination studies demonstrated strong interaction between Nx and radiation both in vitro in multiple PCa cell lines and in the Transgenic adenocarcinoma of mouse prostate (TRAMP) model. Nx potentiated growth inhibitory effects of IR by down regulating ribosomal protein S6K (RPS6KB1), CyclinD1, Chk1 and HIF-1 and prolonging G2/M checkpoint block. RPS6KB1 is upregulated in prostate cancers and its expression is correlated with tumor grade. Knockdown of RPS6KB1 in PCa cells increased their sensitivity toward radiation-induced survival inhibition. Overall, we provide scientific evidence (i) in support ofNx as an adjuvant in PCa patients receiving XRT (ii) suggesting that RPS6KB1 is an important player in Nx-mediated combinatorial benefits and emphasizes that RPS6KB1 is a novel target for PCa treatment. These data underscore the need to test the agent in additional preclinical models to validate these observations.
PMID: Phytother Res. 2018 Jul 11. Epub 2018 Jul 11. PMID: 29993148 Abstract Title: Standardized Morinda citrifolia L. and Morinda elliptica L. leaf extracts alleviated fatigue by improving glycogen storage and lipid/carbohydrate metabolism. Abstract: The antifatigue properties of Morinda elliptica (ME) leaf were compared with Morinda citrifolia (MC) leaf extracts. Sixty Balb/C mice were administered (N = 10): control water, standardized green tea extract (positive control 200 mg/kg body weight [BW]), either 200 or 400 mg MC/kg BW, or either 200 or 400 mg ME/kg BW). The mice performances, biochemical, and mRNA expressions were evaluated. After 6 weeks, the weight-loaded swimming time to exhaustion in the mice consuming 400 mg MC/kg, were almost five times longer than the control mice. The gene expressions analysis suggested the extracts enhanced performance by improving lipid catabolism, carbohydrate metabolism, electron transport, antioxidant responses, energy production, and tissue glycogen stores. The MC and ME extracts enhanced stamina by reducing blood lactate and blood urea nitrogen levels, increasing liver and muscle glycogen reserve through augmenting the glucose metabolism (glucose transporter type 4 and pyruvate dehydrogenase kinase 4), lipid catabolism (acyl-Coenzyme A dehydrogenases and fatty acid translocase), antioxidant (superoxide dismutase 2) defence responses, electron transport (COX4I2), and energy production (PGC1, NRF1, NRF2, cytochrome C electron transport, mitochondrial transcription factor A, UCP1, and UCP3) biomarkers. The MC (containing scopoletin and epicatechin) was better than ME (containing only scopoletin) or green tea (containing epicatechin and GT catechins) for alleviating fatigue.
PMID: Oxid Med Cell Longev. 2018 ;2018:1039364. Epub 2018 Mar 25. PMID: 29765488 Abstract Title: L. Leaf Extract Protects against Cerebral Ischemia and Osteoporosis in anExperimental Model of Menopause. Abstract: We aimed to determine the protective effects against cerebral ischemia and osteoporosis ofextract in experimental menopause. The neuroprotective effect was assessed by givingleaf extract at doses of 2, 10, and 50mg/kg BW to the bilateral ovariectomized (OVX) rats for 7 days. Then, they were occluded in the right middle cerebral artery (MCAO) for 90 minutes. The neurological score, brain infarction volume, oxidative stress status, and ERK1/2 and eNOS activities were assessed 24 hours later.improved neurological score, brain infarction, and brain oxidative stress status in the cortex of OVX rats plus the MCAO. No changes in ERK 1/2 signal pathway and NOS expression were observed in this area. Our data suggested that the neuroprotective effect of the extract might occur partly via the improvement of oxidative stress status in the cortex. The antiosteoporotic effect in OVX rats was also assessed after an 84-day intervention of. The serum levels of calcium, osteocalcin, and alkaline phosphatase and osteoblast density in the tibia were increased, but the density of osteoclast was decreased in OVX rats which received the extract. Therefore, the current data suggested that the extract possessed antiosteoporotic effect by increasing bone formation but decreasing bone resorption.
PMID: J Integr Med. 2018 05 ;16(3):199-207. Epub 2018 Apr 12. PMID: 29691190 Abstract Title: Noni (Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes of old F344 rats. Abstract: OBJECTIVE: Aging is associated with the development of diseases because of immunosuppression and altered functioning of the neuroendocrine system. The medicinal properties of Morinda citrifolia L. have been widely exploited for the treatment of age-associated diseases. This study aims to investigate the in vitro and in vivo effects of noni (M. citrifolia) fruit juice (NFJ) on neuro-immunomodulation in the lymph node lymphocytes of F344 rats.METHODS: Lymphocytes isolated from axillary and inguinal lymph nodes of young (3-4months) and old (18-21months) rats were treated in vitro with different concentrations (0.0001%, 0.01%, and 1%) of NFJ for a period of 24h. In the in vivo study, old (16-17months) male F344 rats were treated with 5mL/kg body weight of 5%, 10% and 20% of NFJ, twice a day, by oral gavage, and lymph node lymphocytes were isolated after 60d. Concanavalin A (Con A)-induced lymphocyte proliferation, interleukin-2 (IL-2) and interferon- (IFN-) production and expression of intracellular markers, such as phospho-extracellular signal-regulated kinase (p-ERK1/2), phospho-cAMP response element-binding protein, phospho-protein kinase B (p-Akt), phospho-tyrosine hydroxylase (p-TH), phospho-nuclear factor of light polypeptide gene enhancer in B-cells inhibitor- (p-IB-) and phospho-nuclear factor-B (p-NF-B p65 and p50) were examined in the lymphocytes of lymph nodes.RESULTS: NFJ increased Con A-induced lymphocyte proliferation, IL-2 and IFN- production, and p-ERK1/2 expression both in vitro and in vivo. In in vivo NFJ-treated old rats, lymph node lymphocytes showed increased expression of p-TH and Akt, nitric oxide production and decreased expression of p-NF-B p65 and p50.CONCLUSION: These results suggest that the immunostimulatory properties of NFJ are facilitated through intracellular signaling pathways involving ERK1/2, Akt and NF-B.
Today, I really dont care if you are a Republican, a Democrat, a Libertarian, or unaffiliated with any political party. Today is a We day By Kent Heckenlively, JD As President John F. Kennedy once said, Our most common basic link is that we all inhabit this planet. We breathe the same air. We cherish our Continue reading WE WON!!! Monsanto Must Pay $289 Million in Damages for Round-Up
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PMID: Molecules. 2018 Jan 29 ;23(2). Epub 2018 Jan 29. PMID: 29382154 Abstract Title: Chemical Constituents and Antioxidant, Anti-Inflammatory and Anti-Tumor Activities of Melilotus officinalis (Linn.) Pall. Abstract: Two new p-hydroxybenzoic acid glycosides, namely p-hydroxybenzoic acid-4---d-manopyranosyl-(1 3)--l-rhamnopyranoside (compound) and 4---l-rhamnopyran-osyl-(1 6)--d-manopyranosyl-(1 3)--l-rhamnopyranoside (compound), and seven known compounds, compound,,(acid components), compound,(flavonoids), compound(a coumarin) and compound(an alkaloid), were isolated from the 70% ethanol aqueous extract of the aerial parts of(Linn.) Pall. The structures of all compounds were elucidated by use of extensive spectroscopic methods Infrared Spectroscopy (IR), High resolution electrospray ionization mass spectrometry (HR-ESI-MS), andH andC-NMR). Sugar residues obtained after acid hydrolysis were identified by high-performance liquid chromatography (HPLC). The antioxidant activity of all the compounds was evaluated by 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH). The anti-inflammatory effects of the compounds were also evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. All compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E 2 (PGE 2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2), respectively, in LPS-stimulated RAW 264.7 cells. The inhibitory effect of all the compounds on MCF-7 cells was determined by Cell Counting Kit-8 (CCK-8) method. The results showed that compounds,,,,exhibited better antioxidant activity compared to the other compounds. compounds-had different inhibitory effects on the release of NO, TNF- and IL-6 in LPS-stimulated RAW264.7 cells by LPS, of which compoundwas the most effective against inflammatory factors. compoundsandhave better antitumor activity compared to other compounds. Further research to elucidate the chemical composition and pharmacological effects of(Linn.) Pall is of major importance towards the development and foundation of clinical application of the species.
PMID: Appl Biochem Biotechnol. 2018 Jul 24. Epub 2018 Jul 24. PMID: 30039473 Abstract Title: Identification of Antioxidant and Anti--amylase Components in Lotus (Nelumbo nucifera, Gaertn.) Seed Epicarp. Abstract: Lotus seed epicarp, a byproduct of lotus seed production process, is usually discarded as a waste. In this study, antioxidant and anti--amylase activities of freeze-dried water and various methanol extracts of lotus seed epicarp were evaluated. The extract obtained by 80% methanol exhibited the strongest DPPH and ABTS radical scavenging activity and ferric reducing power, as well as the greatest inhibitory potential on -amylase. The excellent antioxidant and -amylase inhibitory activities of 80% methanol extract might be attributed to its highest concentrations of total phenolics, flavonoids, and condensed tannins. The inhibition kinetic analysis revealed that the 80% methanol extract was a reversible and uncompetitive-type inhibitor of -amylase. Furthermore, based on MALDI-TOF-MS and thiolysis-HPLC-ESI-MS, the main active components present in 80% methanol extract were identified to be B-type heteropolymeric condensed tannins built up of mixtures of propelargonidins, procyanidins, and prodelphinidins, with thepredominance of procyanidins and epicatechin as the main constitutive units. The results obtained suggested that lotus seed epicarp could be exploited as a potential source of natural antioxidants and -amylase inhibitors.
PMID: BMC Complement Altern Med. 2018 Apr 10 ;18(1):126. Epub 2018 Apr 10. PMID: 29631586 Abstract Title: Withania somnifera modulates cancer cachexia associated inflammatory cytokines and cell death in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's). Abstract: BACKGROUND: Cancer and inflammation are associated with cachexia. Withania somnifera (W. somnifera) possesses antioxidant and anti-inflammatory potential. We investigated the potential of an aqueous extract of the root of W. somnifera (W) to modulate cytokines, antioxidants and apoptosis in leukaemic THP-1 cells and peripheral blood mononuclear cells (PBMC's).METHODS: Cytotoxcity of Wwas determined at 24 and 72 h (h). Oxidant scavenging activity of Wwas evaluated (2, 2-diphenyl-1 picrylhydrazyl assay). Glutathione (GSH) levels, caspase (-8, -9, -3/7) activities and adenosine triphosphate (ATP) levels (Luminometry) were thereafter assayed. Tumour necrosis factor- (TNF-), interleukin (IL)-6, IL-1 and IL-10 levels were also assessed using enzyme-linked immunosorbant assay.RESULTS: At 24 h, W(0.2-0.4 mg/ml) decreased PBMC viability between 20 and 25%, whereas it increased THP-1 viability between 15 and 23% (p
PMID: Biomed Res Int. 2018 ;2018:4076430. Epub 2018 Jan 24. PMID: 29670898 Abstract Title: Effects ofon Reproductive System: A Systematic Review of the Available Evidence. Abstract: Introduction: (WS) also known as ashwagandha is a well-known medicinal plant used in traditional medicine in many countries for infertility treatment. The present study was aimed at systemically reviewing therapeutic effects of WS on the reproductive system.Methods: This systematic review study was designed in 2016. Required data were obtained from PubMed, Scopus, Google Scholar, Cochrane Library, Science Direct, Web of Knowledge, Web of Science, and manual search of articles, grey literature, reference checking, and expert contact.Results: WS was found to improve reproductive system function by many ways. WS extract decreased infertility among male subjects, due to the enhancement in semen quality which is proposed due to the enhanced enzymatic activity in seminal plasma and decreasing oxidative stress. Also, WS extract improved luteinizing hormone and follicular stimulating hormone balance leading to folliculogenesis and increased gonadal weight, although some animal studies had concluded that WS had reversible spermicidal and infertilizing effects in male subjects.Conclusion: WS was found to enhance spermatogenesis and sperm related indices in male and sexual behaviors in female. But, according to some available evidences for spermicidal features, further studies should focus on the extract preparation method and also dosage used in their study protocols.
PMID: Metab Brain Dis. 2018 Aug ;33(4):1261-1274. Epub 2018 Apr 18. PMID: 29671210 Abstract Title: Indian Ginseng (Withania somnifera) supplementation ameliorates oxidative stress and mitochondrial dysfunctions in experimental model of stroke. Abstract: Stroke is an increasingly prevalent clinical condition and second leading cause of death globally. The present study evaluated the therapeutic potential of Indian Ginseng, also known as Withania somnifera (WS), supplementation on middle cerebral artery occlusion (MCAO) induced mitochondrial dysfunctions in experimental model of ischemic stroke. Stroke was induced in animals by occluding the middle cerebral artery, followed by reperfusion injury. Ischemia reperfusion injury resulted in increased oxidative stress indicated by increased reactive oxygen species and protein carbonyl levels; compromised antioxidant system; in terms of reduced superoxide dismutase and catalase activity, along with reduction in GSH levels and the redox ratio, impaired mitochondrial functions and enhanced expression of apoptosis markers. Ischemia reperfusion injury induced mitochondrial dysfunctions in terms of (i) reduced activity of the mitochondrial respiratory chain enzymes, (ii) reduced histochemical staining of complex-II and IV, (iii) reduced in-gel activity of mitochondrial complex-I to V, (iv) mitochondrial structural changes in terms of increased mitochondrial swelling, reduced mitochondrial membrane potential and ultrastructural changes. Additionally, an increase in the activity of caspase-3 and caspase-9 was also observed, along with altered expression of apoptotic proteins Bcl-2 and Bax in MCAO animals. MCAO animals also showed significant impairment in cognitive functions assessed using Y maze test. WS pre-supplementation, on the other hand ameliorated MCAO induced oxidative stress, mitochondrial dysfunctions, apoptosis and cognitive impairments. The results show protective effect of WS pre-supplementation in ischemic stroke and are suggestive of its potential application in stroke management.
PMID: J Nutr. 2014 Jul ;144(7):1099-105. Epub 2014 May 14. PMID: 24828025 Abstract Title: Consumption of sugar-sweetened beverages is positively related to insulin resistance and higher plasma leptin concentrations in men and nonoverweight women. Abstract: The mechanisms for the association of the consumption of sugar-sweetened beverages (SSBs) with obesity and type 2 diabetes are only partly understood. The objective of the study was to examine the association of habitual SSB consumption with biomarkers of energy metabolism, including serum glucose, glycated hemoglobin, insulin, insulin resistance [homeostasis model assessment of insulin resistance (HOMA-IR)], and leptin. Data were taken from the Study on Nutrition and Cardiovascular Risk in Spain (ENRICA), a cross-sectional study conducted during 2008-2010 in 7842 individuals representative of the population of Spain aged 18-59 y. Diet was assessed with a validated computerized diet history. Biomarkers were determined in 12-h fasting blood samples. Analyses were performed with linear regression with adjustment for the main confounders, including body mass index (BMI), waist circumference, and morbidity. In men, a 1-serving (200 mL)/d increase in the consumption of SSBs was associated with higher plasma concentrations of insulin (2.14%, P = 0.01), higher HOMA-IR (1.90%, P = 0.04), and higher concentrations of leptin (2.73%, P = 0.01). Among women, these associations were found only in those with a BMI
PMID: J Hepatol. 2015 Aug ;63(2):462-9. Epub 2015 Jun 5. PMID: 26055949 Abstract Title: Sugar-sweetened beverage, diet soda, and fatty liver disease in the Framingham Heart Study cohorts. Abstract: BACKGROUND & AIMS: Non-alcoholic fatty liver disease affects30% of US adults, yet the role of sugar-sweetened beverages and diet soda on these diseases remains unknown. We examined the cross-sectional association between intake of sugar-sweetened beverages or diet soda and fatty liver disease in participants of the Framingham Offspring and Third Generation cohorts.METHODS: Fatty liver disease was defined using liver attenuation measurements generated from computed tomography in 2634 participants. Alanine transaminase concentration, a crude marker of fatty liver disease, was measured in 5908 participants. Sugar-sweetened beverage and diet soda intake were estimated using a food frequency questionnaire. Participants were categorized as either non-consumers or consumers (3 categories: 1 serving/month to
PMID: Mayo Clin Proc. 2015 Jun ;90(6):813-23. PMID: 26046414 Abstract Title: Diabetes and Kidney Disease in American Indians: Potential Role of Sugar-Sweetened Beverages. Abstract: Since the early 20th century, a marked increase in obesity, diabetes, and chronic kidney disease has occurred in the American Indian population, especially the Pima Indians of the Southwest. Here, we review the current epidemic and attempt to identify remediable causes. A search was performed using PubMed and the search terms American Indian and obesity, American Indian and diabetes, American Indian and chronic kidney disease, and American Indian and sugar or fructose, Native American, Alaska Native, First Nations, Aboriginal, Amerind, and Amerindian for American Indian for articles linking American Indians with diabetes, obesity, chronic kidney disease, and sugar; additional references were identified in these publications traced to 1900 and articles were reviewed if they were directly discussing these topics. Multiple factors are involved in the increased risk for diabetes and kidney disease in the American Indian population, including poverty, overnutrition, poor health care, high intake of sugar, and genetic mechanisms. Genetic factors may be especially important in the Pima, as historical records suggest that this group was predisposed to obesity before exposure to Western culture and diet. Exposure to sugar-sweetened beverages may also be involved in the increased risk for chronic kidney disease. In these small populations in severe health crisis, we recommend further studies to investigate the role of excess added sugar, especially sugar-sweetened beverages, as a potentially remediable risk factor.
PMID: Atherosclerosis. 2014 May ;234(1):11-6. Epub 2014 Feb 15. PMID: 24583500 Abstract Title: Sugar sweetened beverages consumption and risk of coronary heart disease: a meta-analysis of prospective studies. Abstract: OBJECTIVE: To summarize the evidence with respect to sugar sweetened beverages (SSBs) consumption and risk of coronary heart disease (CHD) and to recommend field standards for future analysis on this topic.METHODS: We searched for articles published up to February 2013 through PubMed, EMbase, and Cochrane Library Database and reviewed reference list of the retrieved articles. Prospective studies with reported relative risks (RRs) with 95% confidence intervals (CIs) of CHD for different categories of SSBs consumption were included. Random-effects models were used to evaluate the associations by comparing the highest and lowest categories of SSBs consumption in relation to risk of CHD.RESULTS: Four prospective studies with 7396 CHD cases among 173,753 participants were included in the meta-analysis. The pooled RR (95% CI) for CHD in the highest category of SSBs consumption in comparison with the lowest category of SSBs was 1.17 (1.07-1.28). Stratified analyses indicated a significant association for men but not for women, with pooled RRs (95%CI) of 1.17 (1.05-1.29) and 1.19 (0.94-1.50), respectively. For studies carried out in America, the pooled RR for CHD was 1.18 (1.07-1.30). Additionally, a one-severing per day increase in SSBs consumption was associated with a 16% increased risk of CHD (RR: 1.16, 95%CI: 1.10-1.23).CONCLUSION: Our meta-analysis of four studies suggests that consumption of SSBs may increase risk of CHD, especially among men and American populations. However, this finding was based on limited studies; further studies are warranted to critically evaluate the relationship.
PMID: Nutrients. 2014 Jul 28 ;6(8):2987-99. Epub 2014 Jul 28. PMID: 25072269 Abstract Title: Association between intake of sugar-sweetened beverages and circulating 25-hydroxyvitamin D concentration among premenopausal women. Abstract: Intake of sugar-sweetened beverages has increased in North America and seems to have several adverse health effects possibly through decreased circulating 25-hydroxyvitamin D (25(OH)D) concentrations. The aim of this cross-sectional study was to evaluate the association between sugar-sweetened beverages intake and 25(OH)D concentrations among premenopausal women. Intake of sugar-sweetened beverages including colas, other carbonated beverages and sweet fruit drinks was assessed using a validated food frequency questionnaire among 741 premenopausal women. Plasma concentrations of 25(OH)D were quantified by radioimmunoassay. The association between sugar-sweetened beverages intake and 25(OH)D concentrations was evaluated using multivariate generalized linear models and Spearman correlations. A higher intake of colas was associated with lower mean 25(OH)D levels (67.0, 63.7, 64.7 and 58.5 nmol/L for never,3 servings/week, respectively; r = -0.11 (p = 0.004)). A correlation was observed between intake of other carbonated beverages and 25(OH)D concentrations but was not statistically significant (r = -0.06 (p = 0.10)). No association was observed between intake of sweet fruit drinks and 25(OH)D concentrations. This study suggests that high intake of colas may decrease 25(OH)D levels in premenopausal women. Considering the high consumption of these drinks in the general population and the possible consequences of vitamin D deficiency on health, this finding needs further investigation.
PMID: Am J Cardiol. 2014 May 1 ;113(9):1574-80. Epub 2014 Feb 12. PMID: 24630785 Abstract Title: Impact of sugar-sweetened beverages on blood pressure. Abstract: The impact of sugar-sweetened beverages (SSBs) on blood pressure (BP) has been debated, with some evidence suggesting that their increased intake is related to higher risk of developing hypertension. We conducted a systematic review exploring the relation between consumption of SSB and BP. A comprehensive search in 5 electronic databases along with a bibliography search was performed. The keywords"sugar sweetened beverages,""sugary drinks,""added sugars,""blood pressure,"and"hypertension"were indexed in all combinations. Studies were included that reported the effects of intake of SSBs on BP. We excluded studies with
PMID: Pac Health Dialog. 2014 Mar ;20(1):31-8. PMID: 25928993 Abstract Title: Sugar-sweetened beverages, urate, gout and genetic interaction. Abstract: The clinical manifestations of gout occur as a result of immune responses to monosodium urate crystals. Elevated serum levels of urate (hyperuricemia) are a prerequisite for the development of gout with reduced fractional renal excretion of uric acid (FEUA) an important cause. In New Zealand, Mori and Pacific Island people have inherently raised urate levels with one consequence a higher prevalence of more severe gout. One characteristic metabolic effect of fructose, present in sugar-sweetened beverages (SSB), is raised urate from hepatic processing of fructose. Here we discuss, and place in a biological context evidence, linking consumption of SSB with hyperuricemia and gout, including the first review of recent ecological and clinical studies of the impact of fructose and SSB exposure in Pacific Island people. Both increased serum urate and increased FEUA are observed in clinical studies examining the effects of an acute fructose load. In contrast, chronic exposure to increased fructose in the diet also leads to increased serum urate concentrations, but reduced FEUA. Epidemiological studies have consistently associated SSB consumption with increased serum urate levels andincreased risk of gout. Non-additive interaction of SSB consumption with a genetic variant of a uric acid transporter in serum urate levels and gout risk emphasizes the causality of SSB in gout. Taken together these data demonstrate the hyperuricemic effect of SSB and fructose, with biochemical pathways reasonably well understood. The evidence that dietary fructose increases urate is strong. The evidence summarized here is of sufficient weight to recommend reduction of SSB consumption, particularly in Pacific Island and Mori people, to reduce the burden of gout.
We are thrilled to report that on Friday a San Francisco jury ordered Monsanto to pay $289.2 million to former school groundskeeper Dewayne Johnson, currently dying of cancer, because the companys popular weed killer Roundup had contributed to his disease. Johnsons lawsuit is the first to go to trial- among hundreds filed in state and federal 
PMID: Case Rep Pulmonol. 2018 ;2018:9724530. Epub 2018 Jun 7. PMID: 29984031 Abstract Title: Diffuse Alveolar Hemorrhage Induced by Vaping. Abstract: There has been a significant increase in electronic cigarette (e-cigarette) use since its introduction in 2007. Ironically, there remains very few published literature on the respiratory complications of e-cigarettes. The use of personalized vaporizers or commonly known as"vaping"has started to overtake standard e-cigarette. Its dynamic vaporizer customization makes it challenging to assess long-term health effects. Case reports on the pulmonary complications of e-cigarettes are limited to bronchiectasis, eosinophilic pneumonia, pleural effusion, and suspected hypersensitivity pneumonitis. Diffuse alveolar hemorrhage (DAH) is bleeding into the alveolar spaces of the lung secondary to disruption of the alveolar-capillary basement membrane. We report a case of young male presenting with subacute respiratory failure. He was later found to have diffuse alveolar hemorrhage syndrome that is likely induced by aggressive vaping. This adds up to the rising concern on the possible serious complications of this innovative technology designed as a safer alternative to traditional cigarettes.
Dane Wigington GeoengineeringWatch.org The global climate engineering assault continues to be ramped up, geoengineering operations are mathematically the greatest and most immediate threat we collectively face. Though there are countless forms of anthropogenic damage to the biosphere and climate system, in regard to the off the scale increases in wildfires, and in regard to the unprecedented
PMID: BMJ. 2015 Jul 21 ;351:h3576. Epub 2015 Jul 21. PMID: 26199070 Abstract Title: Consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice and incidence of type 2 diabetes: systematic review, meta-analysis, and estimation of population attributable fraction. Abstract: OBJECTIVES: To examine the prospective associations between consumption of sugar sweetened beverages, artificially sweetened beverages, and fruit juice with type 2 diabetes before and after adjustment for adiposity, and to estimate the population attributable fraction for type 2 diabetes from consumption of sugar sweetened beverages in the United States and United Kingdom.DESIGN: Systematic review and meta-analysis.DATA SOURCES AND ELIGIBILITY: PubMed, Embase, Ovid, and Web of Knowledge for prospective studies of adults without diabetes, published until February 2014. The population attributable fraction was estimated in national surveys in the USA, 2009-10 (n = 4729 representing 189.1 million adults without diabetes) and the UK, 2008-12 (n = 1932 representing 44.7 million).SYNTHESIS METHODS: Random effects meta-analysis and survey analysis for population attributable fraction associated with consumption of sugar sweetened beverages.RESULTS: Prespecified information was extracted from 17 cohorts (38,253 cases/10,126,754 person years). Higher consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, by 18% per one serving/day (95% confidence interval 9% to 28%, I(2) for heterogeneity = 89%) and 13% (6% to 21%, I(2) = 79%) before and after adjustment for adiposity; for artificially sweetened beverages, 25% (18% to 33%, I(2) = 70%) and 8% (2% to 15%, I(2) = 64%); and for fruit juice, 5% (-1% to 11%, I(2) = 58%) and 7% (1% to 14%, I(2) = 51%). Potential sources of heterogeneity or bias were not evident for sugar sweetened beverages. For artificially sweetened beverages, publication bias and residual confounding were indicated. For fruit juice the finding was non-significant in studies ascertaining type 2 diabetes objectively (P for heterogeneity = 0.008). Under specified assumptions for population attributable fraction, of 20.9 million events of type 2 diabetes predicted to occur over 10 years in the USA (absolute event rate 11.0%), 1.8 million would be attributable to consumption of sugar sweetened beverages (population attributable fraction 8.7%, 95% confidence interval 3.9% to 12.9%); and of 2.6 million events in the UK (absolute event rate 5.8%), 79,000 would be attributable to consumption of sugar sweetened beverages (population attributable fraction 3.6%, 1.7% to 5.6%).CONCLUSIONS: Habitual consumption of sugar sweetened beverages was associated with a greater incidence of type 2 diabetes, independently of adiposity. Although artificially...
by Heather Callaghan, Editor
It is with great relief that we announce the following: Monsanto corporation now a part of Bayer lost the trial of the century against a man dying of cancer, his cancer alleged to be caused by Roundup herbicide. The corporation was found by a jury to be responsible for all claims and ordered to pay $250 million dollars in punitive damages to school groundskeeper Dewayne Johnson, whos life and limb are stricken with deadly lymphoma after years of using Roundup Pro and Ranger Pro.
Forty-six-year-old Dewayne Lee Johnson filed the civil suit against the pesticide manufacturer.
Johnsons attorneys say he was diagnosed with non-Hodgkins Lymphoma after spraying Roundup weed killer for two and a half years.
Monsanto released a statement regarding Fridays verdict:
We are sympathetic to Mr. Johnson and his family. Todays decision does not change the fact that more than 800 scientific studies and reviews and conclusions by the U.S. Environmental Protection Agency, the U.S. National Institutes of Health and regulatory authorities around the world support the fact that glyphosate does not cause cancer, and did not cause Mr. Johnsons cancer. We will appeal this decision and continue to vigorously defend this product, which has a 40-year history of safe use and continues to be a vital, effective, and safe tool...
PMID: PLoS One. 2014 ;9(6):e99816. Epub 2014 Jun 17. PMID: 24937507 Abstract Title: Sugar-sweetened beverage intake and cancer recurrence and survival in CALGB 89803 (Alliance). Abstract: BACKGROUND: In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown.METHODS: We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models.RESULTS: Patients consuming 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming
PMID: Lipids Health Dis. 2018 Jul 27 ;17(1):175. Epub 2018 Jul 27. PMID: 30053819 Abstract Title: Antihyperlipidemic efficacy of aqueous extract of Stevia rebaudiana Bertoni in albino rats. Abstract: BACKGROUND: Stevia (Stevia rebaudiana Bertoni) natural, safe, non-toxic, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of hyperlipidemia.METHODS: The present research was carried out to explore the anti-hyperlipidemic effect of aqueous extract of Stevia rebaudiana Bertoni leaves in albino rats. For this purpose, hyperlipidemia was induced by administration of Cholesterol (90% E, Appli Chem, Darmstadt, Germany) mixed at dose of 400 mg/kg body weight of rats in their daily routine feed. The hyperlipidemic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w.) for 8 weeks; the control rats were fed basal diet during this period. Ethical approval for the current research was obtained from Institutional Review Board Faculty of Science&Technology Government College University, Faisalabad, Pakistan.RESULTS: Stevia aqueous extract decreased the body weight gain by lowering the feed intake of hyperlipidemic rats. Furthermore, administration of stevia extract at different levels significantly (P
Im sure all the politicians currently owned by Big $ugar are tired of us talking about this topic but until they make the needed changes to our laws, we are going to keep on them about it. We are going to write stories and interview experts. We are going to make documentaries and protest. It 
The post This one, simple rule change can slash toxic blooms appeared first on Health Nut News.
PMID: BMJ Case Rep. 2018 Jul 6 ;2018. Epub 2018 Jul 6. PMID: 29982176 Abstract Title: Respiratory failure caused by lipoid pneumonia from vaping e-cigarettes. Abstract: A young female vaper presented with insidious onset cough, progressive dyspnoea on exertion, fever, night sweats and was in respiratory failure when admitted to hospital. Clinical examination was unremarkable. Haematological tests revealed only thrombocytopenia, which was long standing, and her biochemical and inflammatory markers were normal. Chest radiograph and high-resolution CT showed diffuse ground-glass infiltrates with reticulation. She was initially treated with empirical steroids and there was improvement in her oxygenation, which facilitated further tests. Since the bronchoscopy and high-volume lavage was unyielding, a video-assisted thoracoscopicsurgical biopsy was done later and was suggestive of lipoid pneumonia. The only source of lipid was the vegetable glycerine found in e-cigarette (EC). Despite our advice to quit vaping, she continued to use EC with different flavours and there is not much improvement in her clinical and spirometric parameters.
PMID: Vasc Med. 2018 Jun 1:1358863X18779694. Epub 2018 Jun 1. PMID: 29985113 Abstract Title: E-cigarettes and cigarettes worsen peripheral and central hemodynamics as well as arterial stiffness: A randomized, double-blinded pilot study. Abstract: The introduction of electronic cigarettes has led to widespread discussion on the cardiovascular risks compared to conventional smoking. We therefore conducted a randomized cross-over study of the acute use of three tobacco products, including a control group using a nicotine-free liquid. Fifteen active smokers were studied during and after smoking either a cigarette or an electronic cigarette with or without nicotine (eGo-T CE4 vaporizer). Subjects were blinded to the nicotine content of the electronic cigarette and were followed up for 2 hours after smoking a cigarette or vaping an electronic cigarette. Peripheral and central blood pressures as well as parameters of arterial stiffness were measured by a Mobil-O-Graph device. The peripheral systolic blood pressure rose significantly for approximately 45 minutes after vaping nicotine-containing liquid ( p
PMID: Neuromolecular Med. 2018 Sep ;20(3):343-362. Epub 2018 May 30. PMID: 29846872 Abstract Title: Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation. Abstract: Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammation but due to their adverse effects, their usage is not well accepted. Natural products are emerging better therapeutic agents due to their affordability and inherent pleiotropic biological activities. In Ayurveda, Ashwagandha (Withania somnifera) is well known for its immunomodulatory properties. The current study is an extension of our previous report on in vitro model system and was aimed to investigate anti-neuroinflammatory potential of water extract from the Ashwagandha leaves (ASH-WEX) against systemic LPS-induced neuroinflammation and associated behavioral impairments using in vivo rat model system. Oral feeding of ASH-WEX for 8 weeks significantly ameliorated the anxiety-like behavior as evident from Elevated plus maze test. Suppression of reactive gliosis, inflammatory cytokines production like TNF-, IL-1, IL-6, and expression of nitro-oxidative stress enzymes like iNOS, COX2, NOX2 etc were observed in ASH-WEX-treated animals. NFB, P38, and JNK MAPKs pathways analysis showed their involvement in inflammation suppression which was further confirmed by inhibitor studies. The current study provides first ever preclinical evidence and scientific validation that ASH-WEX exhibits the anti-neuroinflammatory potential against systemic LPS-induced neuroinflammation and ameliorates associated behavioral abnormalities. Aqueous extract from Ashwagandha leaves and its active phytochemicals may prove to be promising candidates to prevent neuroinflammation associated with various neuropathologies.
PMID: J Clin Psychiatry. 2018 Jul 10 ;79(5). Epub 2018 Jul 10. PMID: 29995356 Abstract Title: Adjunctive Use of a Standardized Extract of Withania somnifera (Ashwagandha) to Treat Symptom Exacerbation in Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Study. Abstract: OBJECTIVE: To determine if adjunctive treatment with a standardized extract of Withania somnifera (WSE), with known anti-inflammatory and immunomodulating properties, improves psychopathology and stress in patients with schizophrenia or schizoaffective disorder (DSM-IV-TR).METHODS: Patients experiencing an exacerbation of symptoms were assigned to WSE (1,000 mg/d) or placebo for 12 weeks, added to their antipsychotic medication, in a random-assignment, double-blind, placebo-controlled study conducted from April 2013 to July 2016. Primary outcomes were change from baseline to end of treatment on the Positive and Negative Syndrome Scale (PANSS total, positive, negative, and general symptoms) between treatment groups. Secondary outcomes evaluated stress and inflammatory indices using the Perceived Stress Scale (PSS), S100 calcium-binding protein B (S100B), and C-reactive protein (CRP).RESULTS: Sixty-six randomized patients (n = 33 per group) provided efficacy data. Beginning at 4 weeks and continuing to the end of treatment, WSE produced significantly greater reductions in PANSS negative, general, and total symptoms (Cohen d: 0.83, 0.76, 0.83), but not positive symptoms, when compared to placebo. PSS scores improved significantly with WSE treatment compared to placebo (Cohen d: 0.58). CRP and S100B declined more in the WSE group but were not significantly different from placebo. Adverse events were mild to moderate and transient; somnolence, epigastric discomfort, and loose stools were more common with WSE. No significant between-treatment differences were noted in body weight, vital signs, or laboratory measures, which remained stable.CONCLUSIONS: This early study suggests that adjunctive treatment with a standardized extract of Withania somnifera provides significant benefits, with minimal side effects, for negative, general, and total symptoms and stress in patients with recent exacerbation of schizophrenia.TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT01793935.
PMID: Rehabil Res Pract. 2018 ;2018:3820615. Epub 2018 Jun 5. PMID: 29971166 Abstract Title: Acute Whole Body Vibration Decreases the Glucose Levels in Elderly Diabetic Women. Abstract: Type II diabetes (TIIDM) is characterized by high levels of blood glucose followed by excessive insulin release so that the target cells become less sensitive, developing insulin resistance and maintaining hyperglycemic levels. Physical activity is the strongest element to prevent and to manage the TIIDM, and the majority of patients do not remain in regularly active levels, because the premature fatigue in these patients decreases the adherence to the training. Contrastingly, the whole body vibration (WBV) training may improve the glucose metabolism in diabetic patients, reducing the peripheral blood sugar, decreasing the physical discomfort and perceived exertion. Therefore, the purpose of the study was to determine the effect of an acute WBV session as therapy to promote fasting decreases in insulin levels in peripheral blood in TIIDM when compared to healthy elderly. For this, fifteen healthy elderly women and fourteen diabetic elderly women, all sedentary, were allocated in diabetic or control groups, and we made an acute whole body session composed of 10 bouts lasting 2 minutes each one, separated by a 30-second rest period. The WBV was executed in a triaxial platform MY3 Power Plate at 35 hertz and has been chosen a peak-to-peak displacement of 4 millimeters. After the protocol, both groups decreased the glycemic levels and increased lactate production in relation to the basal levels and when compared diabetic and control, where the most important results have been shown indiabetic women. This study revealed that WBV training in TIIDM has had significant beneficial effects on the control of glucose levels, still in an acute session. So that, the complete training probably will show better results about glycemic control and this finding could be especially important when prescribing exercise for elderly who are unable or unwilling to use traditional loads or who show poor exercise compliance.
PMID: Environ Sci Pollut Res Int. 2018 Jun 29. Epub 2018 Jun 29. PMID: 29959737 Abstract Title: Stop eating plastic, molecular signaling of bisphenol A in breast cancer. Abstract: Breast cancer is the second most common fatal cancer in women. Developing a breast cancer is a multi-factorial and hormonal-dependent process, which may be triggered by many risk factors. An endocrine disrupting substance known as bisphenol A (BPA), that is used greatly in the manufacture of plastic products, was suggested as a possible risk factor for developing breast cancer. BPA has a strong binding affinity to non-classical membrane estrogen receptors like estrogen-related and G protein-coupled (GPER) receptors. Based on animal and in vitro studies, results showed a link between BPA exposure and increased incidence of breast cancer. BPA has the ability to alter multiple molecular pathways in cells namely, G protein-coupled receptor (GPER) pathway, estrogen-related receptor gamma (ERR) pathway, HOXB9 (homeobox-containing gene) pathway, bone morphogenetic protein 2 (BMP2) and (BMP4), immunoregulatory cytokine disturbance in the mammary gland, EGFR-STAT3 pathway, FOXA1 in ER-breast cancer cells, enhancer of zeste homolog 2 (EZH2), and epigenetic changes. Thus, the aforementionedalterations cause undesired gene stimulation or repression that increase risk of developing breast cancer. So, restricting exposure to BPA should be considered to aid in lowering the risk of developing breast cancer.
PMID: Environ Int. 2018 Jul 7 ;119:319-326. Epub 2018 Jul 7. PMID: 29990952 Abstract Title: Exposure and dietary sources of bisphenol A (BPA) and BPA-alternatives among mothers in the APrON cohort study. Abstract: Diet is regarded as the main source of bisphenol A (BPA) exposure, but comparatively little is known about dietary sources of BPA-alternatives. Here we measured exposure of BPA and BPA-alternatives among pregnant women in Canada, estimated their 24-h intakes and examined the importance of various dietary sources. Free and total BPA, bisphenol S (BPS) and bisphenol F (BPF) were measured in 467 second trimester maternal urine samples, and in 455 paired samples collected at three months postpartum. Linear regression was used to evaluate associations between urinary concentrations of bisphenols and 24-h dietary recall data. The geometric means of total BPA in second trimester and postpartum urine (1.2 and 0.95ng/mL, respectively) were 5-7 times higher than corresponding total BPS (0.16 and 0.17ng/mL). The detection frequency of BPF was only 9% (i.e.>1.0ng/mL). However, at both time points 95th percentiles of total BPF (7.3 and 4.2ng/mL, respectively) were similar to total BPA (8.2 and 5.0ng/mL). Free BPS and BPF were detected in
PMID: Epigenetics. 2018 Jul 12. Epub 2018 Jul 12. PMID: 30001178 Abstract Title: Gene Expression and DNA Methylation Changes in the Hypothalamus and Hippocampus of Adult Rats Developmentally Exposed to Bisphenol A or Ethinyl Estradiol: A CLARITY-BPA Consortium Study. Abstract: Bisphenol A (BPA), an endocrine disrupting chemical (EDC), is a ubiquitous pollutant. As part of the Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA), we sought to determine whether exposure of Sprague-Dawley rats to 2,500g/kg/day BPA (BPA) or 0.5 g/kg/day ethinyl estradiol (EE) from gestational day 6 through postnatal day 21 induces behavior-relevant gene expression and DNA methylation changes in hippocampus and hypothalamus at adulthood. RNA and DNA were isolated from both regions. Expression of ten genes (Dnmt1, Dnmt3a, Dnmt3b, Esr1, Esr2, Avp, Ar, Ot, Otr, and Bdnf) presumably altered by early-life BPA/EE-exposure was examined. Three genes (Bdnf, Dnmt3b, and Esr1) were studied for DNA methylation changes in their putative 5' promoter regions. Molecular changes in hippocampus were correlated to prior Barnes maze performance, including sniffing correct holes, distance traveled, and velocity. Exposure to BPA and/or EE disrupted patterns of sexually dimorphic gene expression/promoter DNA methylation observed in the hippocampus and hypothalamus of controls. In the hippocampus of female offspring, BPA-exposure resulted in hypermethylation of the putative 5' promoter region of Bdnf, while EE exposure induced hypomethylation. Bdnf methylation was weakly associated with Bdnf expression in hippocampi of female rats. Hippocampal Bdnf expression in females showed a weak negative association with sniffing correct hole in Barnes maze. Hippocampal expression of Avp, Esr2, Oxt, and Otr was strongly associated with velocity of control rats in Barnes maze. Findings suggest BPA exposure induced non-EE-like gene expression and epigenetic changes in hippocampus of adult rats, a region involved in spatial navigation.
by Heather Callaghan, Editor
Our addiction to screens isnt just hurting our social lives or nature its making us physically blind.
University of Toledo researchers made a shocking discovery that the blue light emanating from our smartphones and other screens is literally doing permanent damage to our vision.
A dark room at the University of Toledo is where researchers have found blue light, specifically, leads to macular degeneration.
Macular Degeneration is one of the leading causes of blindness in the United States and all around the world, said assistant professor in the UT Department of Chemistry and Biochemistry, Ajith Karunarathne.
According to this new research, blue light can makes us blind.
The researchers said molecules that we need to be able to see, called retinal, turn into cell killers when they interact with blue light.
We dont really at this point know what is the major cause. We know how it happened because there are multiple paths that...
by Paul Fassa
Health Impact News
The benefits of berberine are not as well known as most supplements on the market. It wasnt even widely available until recently. Yet it has been tried and tested for type 2 diabetes and fat accumulation reduction, including that of fatty liver.
Our diabetic institutions are misleading people with pre-diabetics or metabolic syndrome testing and leading them into full-blown diabetes 2 with their recommendations, while mainstream medicines prescription diabetic drugs are questionably efficacious with dangerous side effects, such as bladder cancer and unpredictable interactions with other drugs.
Dr. Jonathan Wright of the holistic Tahoma Clinic in Washington state notes that several studies have shown that berberine, an alkaloid found in the herb goldenseal and other natural sources, can lower blood glucose as effectively as the drug metformin at similar doses (500 mg 3x/day). (Source)
Berberine is a yellow-colored alkaloid compound found in several different plants with antibacterial, anti-inflammatory, and immune-enhancing properties. Its effective against a wide range of bacteria, protozoa, and fungi. It has been used most commonly for treating gastrointestinal issues, including issues from food poisoning.
However, newer research has uncovered the benefits of berberine, an isoquinoline alkaloid, which are beyond its antimicrobial properties. According to the December 2012 edition of Natural Medicine Journal:
There are 3 general conditions f...
PMID: Int J Environ Health Res. 2018 Oct ;28(5):491-501. Epub 2018 Jul 16. PMID: 30010399 Abstract Title: Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells. Abstract: In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) and BPA residues in some cosmetic samples collected from Tunisian market are evaluated by micro-matrix solid-phase dispersion combined with GC-MS. In parallel, the impact of these molecules and the cosmetics in the human epithelial cell lines is investigated. The cytotoxic activity of cosmetic extracts is evaluated in vitro against B16 and Hep-2 human skin cell lines using the 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. This study shows that the tested cosmetic products could constitute a hazard to the consumer health and wellness and that strict safety analysis on cosmetic products needs to be carried out before they are marketed.
PMID: Environ Health Perspect. 2018 07 ;126(7):077006. Epub 2018 Jul 23. PMID: 30044229 Abstract Title: Longitudinal Effects of Developmental Bisphenol A Exposure on Epigenome-Wide DNA Hydroxymethylation at Imprinted Loci in Mouse Blood. Abstract: BACKGROUND: Epigenetic machinery plays an important role in genomic imprinting, a developmental process that establishes parent-of-origin-specific monoallelic gene expression. Although a number of studies have investigated the role of 5-methylcytosine in imprinting control, the contribution of 5-hydroxymethylcytosine (5-hmC) to this epigenetic phenomenon remains unclear.OBJECTIVES: Using matched mouse blood samples (from mice at 2, 4, and 10 months of age), our objective was to examine the effects of perinatal bisphenol A (BPA) exposure (50g/kg diet) on longitudinal 5-hmC patterns at imprinted regions. We also aimed to test the hypothesis that 5-hmC would show defined patterns at imprinted genes that persist across the life course.METHODS: Genome-wide 5-hmC levels were measured using hydroxymethylated DNA immunoprecipitation sequencing (HMeDIP-seq). Modeling of differential hydroxymethylation by BPA exposure was performed using a pipeline of bioinformatics tools, including theR package.RESULTS: Based on BPA exposure, we identified 5,950 differentially hydroxymethylated regions (DHMRs), including 12 DHMRs that were annotated to murine imprinted genes-,,,,,,,,,, and. When visualized, these imprinted gene DHMRs showed clear, consistent patterns of differential 5-hmC by developmental BPA exposure that persisted throughout adulthood.CONCLUSIONS: These data show long-term establishment of 5-hmC marks at imprinted loci during development. Further, the effect of perinatal BPA exposure on 5-hmC at specific imprinted loci indicates that developmental exposure to environmental toxicants may alter long-term imprinted gene regulation via an epigenetic mechanism. https://doi.org/10.1289/EHP3441.
by John P. Thomas
Health Impact News
With the push of a button, tech companies can make a billion people have the same thought. The tool they use is the smartphone. The thought could be a bit of truth or it could be a lie.
Regardless of the content of the message, they have the power to capture our attention and to insert a thought in our minds, even if the thought only lingers there for a few seconds before we move on to something else. 
This kind of mind control is not accidental but is part of an intentional plan of technology companies to get us addicted to their technology, to steal our time, and to build profitability at our expense. 
Supercomputers have now beaten the best chess masters in the world, and it is these same supercomputers that are used by tech companies to manage smartphone addiction. The process involves collecting information about our interests and using psychological and behavioral methods to get us hooked on their technology.
Unless we understand the techniques being used to get us addicted and take steps to control how we use smartphones and tablets, these devices have a high potential for taking over our lives.
Research shows that it is common for many people to check their phones 150 times a day  and to touch the phone 2,617 times every day. The top 10% of users touch their phones more than 5,400 times daily.  These are signs of technology addiction.
How many times an hour do you check your phone?
Do you spend more time on...
PMID: Mol Cell Endocrinol. 2018 Jul 23. Epub 2018 Jul 23. PMID: 30048677 Abstract Title: Alteration of mammary gland development by bisphenol a and evidence of a mode of action mediated through endocrine disruption. Abstract: The development and function of the mammary gland are endocrine-dependent processes, depending on the stage of development. Foetal and/or postnatal exposure to low doses of BPA alters tissue organisation through epithelial proliferation and stroma-epithelial interactions. BPA also alters the expression of E2-dependent epithelial and stroma transcriptomes. Several signalling pathways are consistent with the observed phenotype: proliferation and apoptosis, a focal adhesion pathway indicating changes in biomechanical properties of the extracellular matrix, and immune function. Some of BPA's effects are reversed by oestrogen and/or GPER inhibitors. BPA also alters the expression of epigenetic marks (EZH2, HOTAIR), which would explain the delayed effect of foetal BPA exposure. In conclusion, experimental evidence shows that pre- or postnatal BPA exposure consistently causes endocrine modifications in the mammary tissue of different animal species, disrupting stromal-epithelial interactions and ultimately increasing its susceptibility to carcinogens. An interspecies comparison highlights why and how these effects apply to humans.
PMID: J AOAC Int. 2018 Jul 31. Epub 2018 Jul 31. PMID: 30064541 Abstract Title: Determination of Bisphenol A (BPA) in Commercially Packaged Ready-to-Consume Carbonated and Noncarbonated Water and Nonalcoholic Beverages: A Single-Laboratory Validation Study, First Action 2017.15. Abstract: Bisphenol A (BPA) is an endocrine-disrupting compound that could migrate to beverages from packaging materials. AOAC INTERNATIONAL issued a call for methods for determination of free BPA in beverages based on the AOAC(SMPR) 2017.018.The objective of the single-laboratory validation (SLV) study was to validate a method for the analysis of BPA in relevant beverages and evaluate its performance characteristics against the AOAC SMPR 2017.18.The analytical method involves extraction of a beverage sample (10 mL) using 10 mL 1% acetic acid in acetonitrile after the addition of isotopically labeled internal standard. Sodium chloride is added to salt out BPA into the acetonitrile phase. After centrifugation, a freeze-out step is used to remove coextracted lipids. An aliquot of the supernatant upper layer is then analyzed using high-pressure LC coupled to tandem mass spectrometry in electrospray negative ionization mode.Accuracy, repeatability, and intermediate precision were determined by spiking 10 representative nonalcoholic beverage matrixes at three concentration levels. Individual percent recoveries ranged between 76.5 and 113.2%, 86.2 and 114.8%, and 90.9 and 109.3% for the spike levels of 0.3, 1.5, and 20g/L, respectively. The repeatability and intermediate precision results were in the range of 0.2-11.3% and 1.8-11.1%, respectively. The LOD was estimated at 0.1 g/L and LOQ was validated at 0.3 g/L.The validated method performance characteristics met the requirements stated in the AOAC SMPR 2017.018. This method was approved AOAC First Action2017.15.SLV study evaluating free BPA at three concentration levels (0.3, 1.5, and 20g/L) in 10 types of commercially packaged nonalcoholic beverages (as recommended for the method validation in the AOAC SMPR 2017.018). Validated method performance characteristics (LOD, LOQ, analytical range, accuracy, and precision) met the AOAC SMPR 2017.018. Method approved as the AOAC First Action2017.15.
PMID: Toxicol Res (Camb). 2018 Jan 1 ;7(1):22-31. Epub 2017 Sep 14. PMID: 30090559 Abstract Title: The effect of bisphenol A on testicular steroidogenesis and its amelioration by quercetin: anandapproach. Abstract: Bisphenol A (BPA), a phenyl ring containing synthetic xenoestrogen, is widely used in the manufacture of polycarbonate plastics, epoxy resins and as a non-polymer additive to other plastics. Food is considered as the main source of exposure to BPA as it leaches out from food containers as well as surface coatings. It causes toxicity in the liver, kidney, brain, and other organs by initiating the process of lipid peroxidation. The present investigation was an attempt to evaluate the effect of BPA on steroidogenesis and its amelioration by quercetin. Inbred Swiss strain male albino mice were orally administered with 80, 120 and 240 mg per kg body weight per day of BPA for 45 days. The results revealed that BPA causes significant (
PMID: PLoS One. 2014 ;9(10):e111383. Epub 2014 Oct 30. PMID: 25356742 Abstract Title: Bisphenol A exposure and asthma development in school-age children: a longitudinal study. Abstract: BACKGROUND: Although the effect of bisphenol A on various health outcomes has been extensively examined, few studies have investigated its effect on asthma.OBJECTIVE: We hypothesized that exposure to bisphenol A in school-age children was associated with wheezing and asthma.METHODS: Participants included 127 children aged 7-8 years without a previous asthma diagnosis in an elementary school in Seoul, Korea. Three surveys were conducted, each 2 years apart. Bisphenol A concentration was measured at the baseline survey, and PC20, which is defined as the methacholine concentration that induces a decrease in FEV1 of 20% from baseline, was measured at every survey. Associations between bisphenol A concentration at 7-8 years of age and wheezing, asthma, and PC20 at ages up to 11-12 years were examined using generalized estimating equations, a marginal Cox regression model, and a linear mixed model.RESULTS: The log-transformed creatinine-adjusted urinary bisphenol A concentration at 7-8 years was positively associated with wheezing (odds ratio, 2.48; 95% confidence interval, 1.15-5.31; P=.02) and asthma (hazard ratio, 2.13; 95% confidence interval, 1.51-3.00; P
(Note from Erin: I personally would especially avoid non-organic sugar or any food items with any sugar in them.) The call to boycott big sugar is spreading like wildfire across social media. Especially here in Florida where we are doing our best to raise awareness. (Weve been writing about the damage they are doing to our water for 
The post NBC: People boycotting sugar in protest of algae crisis appeared first on Health Nut News.
PMID: J Environ Health Sci Eng. 2014 Mar 13 ;12(1):64. Epub 2014 Mar 13. PMID: 24625016 Abstract Title: Association of urinary bisphenol a concentration with type-2 diabetes mellitus. Abstract: BACKGROUND: Bisphenol A as an endocrine-disrupting chemical is widely used chemical in the manufacture of polycarbonate plastics and epoxy resin and has become ubiquitous environmental contaminants. Human exposure to Bisphenol A is widespread and recent studies have been shown to be associated with a higher risk for self-reported adverse health outcomes that may lead to insulin resistance and the development of type-2 diabetes mellitus. In this context, we sought to confirm the association between Bisphenol A and diabetes in a community-based analysis of Bisphenol A urinary concentrations investigation in adult population of Iran.METHODS: Regression models were adjusted for age, sex, Body Mass Index, serum triglyceride level and serum cholesterol level and serum creatinine concentration. Main outcomes were reported diagnoses of diabetes that defined according the latest American Diabetes Association guidelines.RESULTS: The median age of the 239 participants was 51.65 years and 119 people had type-2 diabetes mellitus. Urinary Bisphenol A was categorized into two groups based on the median for Bisphenol A (0. 85 to>0.85 g/L). The results of statistical analysis revealed a clear association between hypertension, and type 2 diabetes (P
If the US government and the FDA have their way, Americans may soon have more access to medications and prescription drugs without having to first see a doctor. This is undoubtedly a positive step in the right direction. Unfortunately, its not exactly what you might think.
For those who are unaware, in the United States, an allegedly free country, American citizens no longer have the option to decide what medications they believe they need or wish to take and simply purchase those medications from a pharmacy as in times past or as in many other countries today. Instead, they are forced to make an appointment with a doctor who is considered (and considers himself) the ultimate authority on what a patient can consume, regardless of the patients choices. Of course, the patient has to pay for that visit and he/she may not even be prescribed the proper medicine even after begging the doctors permission to access it. The patient then has to go to the pharmacy and prove that he has his hall pass (prescription) in order to be receive his medication.
Now, a new draft guideline from the FDA seems to be heading in the opposite direction but seems is the operative word here. The FDA is looking into to how it can lower healthcare costs and one of the options may be opening up certain medications to potential purchase without a doctors visit.
Yesterday, a federal appeals court ordered the EPA to bar within 60 days a widely used pesticide thats been associated with developmental disabilities and other health problems in children. The order by the United States Court of Appeals for the Ninth Circuit came after a decade-long effort by environmental and public health groups to get 
The post Court orders E.P.A to ban pesticide tied to childrens severe health problems appeared first on Health Nut News.
PMID: Acta Paediatr. 2015 Apr ;104(4):e171-7. Epub 2015 Feb 3. PMID: 25469562 Abstract Title: The endocrine disruptor bisphenol A may play a role in the aetiopathogenesis of polycystic ovary syndrome in adolescent girls. Abstract: AIM: Experimental in vitro studies have shown that bisphenol A affects steroidogenesis, folliculogenesis and ovarian morphology. The aim of this study was to investigate the role of the endocrine disruptor bisphenol A in the aetiopathogenesis of polycystic ovary syndrome (PCOS) in adolescents and its relationship with metabolic parameters, insulin resistance and obesity in this population.METHODS: A total of 112 girls with PCOS and 61 controls between 13 and 19 years of age were enrolled in the study. Serum bisphenol A levels were measured by high-pressure liquid chromatography. An oral glucose tolerance test was also performed.RESULTS: Adolescents with PCOS had markedly increased serum bisphenol A levels (mean: 1.1 ng/mL 95% CI: 1.0-1.2) than controls (mean: 0.8 ng/mL 95% CI: 0.6-0.9, p = 0.001). When we compared the subgroups according to obesity, the main factor determining the significant increase in bisphenol A was the presence of PCOS, but not obesity (p = 0.029). Bisphenol A was significantly correlated with total testosterone (r = 0.52), free testosterone (r = 0.44), dehydroepiandrosterone sulphate (r = 0.37) and Ferriman-Gallwey score (r = 0.43) (p
SPECIAL REPORT by Heather Callaghan, Editor
Before you bite into that chicken sandwich before you step foot in another Chick-Fil-A JUST STOP!
Theres something you didnt know about our food system. Sure, if you read our site every day, you know that the food system has resembled a wobbling Jenga stack for quite some time. You know that livestock animals are tortured, pumped full of drugs and antibiotics, brutally killed, treated with chemicals, and then their waste run-off creates toxic waterways.
How bad is it? Americas food system is so bad that Russia used our food supply as an example for why Europe should run screaming from any U.S. trade agreements. That may sound like a punchline, but its no joke.
A new poll finds that New jersey residents are divided over the benefits of fluoridated water.
Fairleigh Dickinson political science professor Dan Cassino says half of New Jerseys residents believe fluoride in drinking water is a good thing while 34 percent are not convinced.
Cassino says Just 15 percent of Garden State residents receive fluoridated water because most municipal water systems in New Jersey serve multiple communities and any of them can prevent fluoride from being added to the water.
The way you set the water system means that even a small group of people who are worried about fluoride being a government mind control plot, which is a more widely accepted view than you might think, can block fluoridation for almost any large municipal water sources.
Cassino says much of the opposition to fluoridation comes from people who dont trust the government.
If you dont trust the government, youre not going to trust it to provide these essential services that you need every day. We all need water. You get it from the government. So if you dont trust the government, youre not going to trust it to do anything, even the stuff you actually need.
The Centers for Disease Control and Prevention says fluoridation is safe and effective in preventing tooth decay.
*Original article online at http://www.wbgo.org/post/many-nj-residents-skeptical-about-benefits-fluoridation#stream/0
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