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Tuesday, 17 April

23:51

Polysaccharides from A. bisporus could be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2017 ;2017:7298683. Epub 2017 Aug 22. PMID: 29104605 Abstract Title:  The Antioxidative, Antiaging, and Hepatoprotective Effects of Alkali-Extractable Polysaccharides by. Abstract:  The aim of this work was designed to investigate the antioxidant, antiaging, and hepatoprotective effects of alkali-extractable polysaccharides (AlAPS) and their three purified fractions (AlAPS-1, AlAPS-2, and AlAPS-3) fromin D-galactose induced aging mice. Forantioxidant analysis, both AlAPS and its fractions exhibited moderate reducing power, Fe-chelating activities, and potent scavenging activities on hydroxyl and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals. Theresults demonstrated that the polysaccharides, especially AlAPS-2, showed potential antiaging and hepatoprotective effects by enhancing the antioxidant status, decreasing serum hepatic enzyme activities, and improving the lipid metabolism. This study suggested that the polysaccharides extracted and purified fromcould be exploited as a potent dietary supplement to attenuate aging and prevent age-related diseases.

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23:43

Antibacterial, antiradical potential and phenolic compounds of thirty-one Polish mushrooms. "IndyWatch Feed Health"

PMID:  PLoS One. 2015 ;10(10):e0140355. Epub 2015 Oct 15. PMID: 26468946 Abstract Title:  Antibacterial, Antiradical Potential and Phenolic Compounds of Thirty-One Polish Mushrooms. Abstract:  BACKGROUND: Among many sources of natural bioactive substances, mushrooms constitute a huge and almost unexplored group. Fungal compounds have been repeatedly reported to exert biological effects which have prompted their use in pharmaceutical and cosmetic industry. Therefore, the aim of this study was analysis of chemical composition and biological activity of 31 wild growing mushroom species (including saprophytic and parasitic) from Poland.METHODS: Qualitative and quantitative LC-ESI-MS/MS analysis of fourteen phenolic acids in the mushrooms analysed was performed. Moreover, total phenolic content was determined by the modified Folin-Ciocalteau method. Antioxidative activity of ethanolic extracts towards DPPH free radical was examined. Antibacterial activity against Gram-positive (S. epidermidis, S. aureus, B. subtilis, M. luteus) and Gram-negative (E. coli, K. pneumoniae, P. aeruginosa, P. mirabilis) microbial strains was analyzed.RESULTS: As a result, the first such broad report on polyphenolic composition, antiradical and antimicrobial potential of wild growing Polish mushrooms was developed. Mushroom extracts were found to contain both benzoic (protocatechuic, 4-OH-benzoic, vanillic, syringic) and cinnamic acid derivatives (caffeic, p-coumaric, ferulic). Total phenolic content in mushrooms ranged between 2.79 and 53.13 mg gallic acid equivalent /g of dried extract in Trichaptum fuscoviolaceum and Fomes fomentarius, respectively. Fungi showed much differentiated antiradical activity, from highly active F. fomentarius to poorly effective Russula fragilis (IC50 1.39 to 120.54 mg per mg DPPH, respectively). A quite considerable relationship between phenolic content and antiradical activity has been demonstrated. Mushrooms varied widely in antimicrobial potential (MIC from 0.156 to 5 mg/ml). Generally, a slightly higher activity against Gram-positive than Gram-negative strains was observed. This is the first study concerning the chemical composition and biological activity of the majority of investigated species.

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23:22

The FREE Online Keto Edge Summit: Leverage the Power of KETONES to Return to Health "IndyWatch Feed Health"

KETOEDGE Summit

Health Impact News

Keto is one of the MOST SEARCHED words on the internet today, and for good reason.

Ketones help you burn fat for energy, powerfully reduce inflammation and show promise in preventing and eradicating diabetes, cancer, autoimmune and neurodegenerative diseases like Alzheimers and Parkinsons, and many, many other health concerns.

The Keto Edge Summit is online and FREE from May 7-13, 2018.

During The Keto Edge Summit, youll discover:

  • What is ketosis (and how does it work)?
  • Myths, and how to separate fact from fiction!
  • How to overcome the challenges of being keto adapted.
  • Whether you should start a keto diet (or not!).
  • How to shop, live and eat on a ketogenic lifestyle.
  • And more!

Your host, Dr. David Jockers, overcame skin cancer in part by switching to a ketogenic diet.

Within 6 months of diagnosis, his cancerous nodule had vanished and, he gained significantly more energy and mental clarity.

Now, he teaches patients how a ketogenic lifestyle can give them the edge to conquer disease, return to health and upgrade quality of life.

Join us online for FREE!

Lear more about the Ketogenic Diet.

...

23:04

The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol. "IndyWatch Feed Health"

PMID:  Int Immunopharmacol. 2018 Jan ;54:286-295. Epub 2017 Nov 24. PMID: 29175507 Abstract Title:  The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol. Abstract:  While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known. We examined the effect of 70% ethanol extract of Chaga mushroom (EE) and its dichloromethane (DF) and aqueous (AF) fractions using a mouse model of chicken ovalbumin (cOVA)-induced food allergy, and found that only EE and DF ameliorated allergy symptoms to a significant extent. The in vivo mast cell-stabilizing activity was also found only in EE and DF whereas the activities to suppress Th2 and Th17 immune responses and cOVA-specific IgE production in the small intestine were observed in all three treatment regimens, implying that inhibition of the mast cell function by lipophilic compounds was vital for the therapeutic effect. Results also indicated that inotodiol, a triterpenoid predominantly present in DF, played an active role as a mast cell stabilizer.

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22:58

Inotodiol can be a preventive approach in managing dietary chronic conditions like diabetic-breast cancer. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2018 Mar ;99:142-150. PMID: 29331760 Abstract Title:  Inotodiol suppresses proliferation of breast cancer in rat model of type 2 diabetes mellitus via downregulation of-catenin signaling. Abstract:  Breast cancer is amongst the most common cancers causing death of women worldwide. Breast cancer occurrence is more prominent in people with diabetes. A recent trend is management of diabetes and cancer has evolved to be natural remedy including single molecule therapy or combination. In this study, we investigated the effect of inotodiol on breast cancer growth in diabetic conditions. Inotodiol is a lanostane triterpenoid found in natural resources like edible mushroom Inonotus obliquus. We established a rat model of diabetic-breast cancer by treating female Sprague-Dawley rats with streptazotocin (STZ) at 35mg/kg followed by induction of breast cancer by administration of 7,12-dimethylbenz(a)anthracene (DMBA) at 10mg/kg. Diabetes development in experimental rats was confirmed by measuring fasting blood glucose levels and oral glucose tolerance test (OGTT), and other biochemical assays were performed. Histological evaluation of pancreas was performed. The proliferation of breast tumor was measured by immunohistochemical staining for PCNA, cleaved-caspase-3 and TUNEL staining for apoptosis, and -catenin. Results of the study demonstrate that inotodiol lowered the blood glucose levels in SDrats as well as reduced plasma levels of cholesterol, triglyceride, and high-density lipoprotein. The tumor proliferation marker PCNA was reduced by inotodiol. It downregulated the expression of -catenin and its downstream targets (c-Myc and Cyclin D1) followed by apoptosis induction. Conclusively, results suggest that inotodiol regulates blood glucose levels in diabetic rats and then controls proliferation of breast tumor progression by inducing apoptosis via downregulation of -catenin signaling. It further suggests that inotodiol can be a preventive approach in managing dietary chronic conditions like diabetic-breast cancer.

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22:53

Growth-inhibitory and immunomodulatory activities of wild mushrooms from North-Central British Columbia. "IndyWatch Feed Health"

PMID:  Int J Med Mushrooms. 2017 ;19(6):485-497. PMID: 29199559 Abstract Title:  Growth-Inhibitory and Immunomodulatory Activities of Wild Mushrooms from North-Central British Columbia (Canada). Abstract:  Wild mushrooms, especially from North America, have not been systematically explored for their medicinal properties. Here we report screening for the growth-inhibitory and immunomodulatory activities of 12 species collected from multiple locations in north-central British Columbia, Canada. Mushrooms were characterized using morphology and DNA sequencing, followed by chemical extraction into 4 fractions using 80% ethanol, 50% methanol, water, and 5% sodium hydroxide. Growth-inhibitory, immunostimulatory, and anti-inflammatory activities of 5 mushrooms (Leucocybe connata, Trichaptum abietinum, Hydnellum sp., Gyromitra esculenta, and Hericium coralloides) are reported here, to our knowledge for the first time. Growth-inhibitory effects were assessed using the cytotoxic MTT assay. Immunostimulatory activity was assessed by tumor necrosis factor- production in Raw 264.7 macrophages, whereas anti-inflammatory activity was assessed based on the inhibition of lipopolysaccharide-induced tumor necrosis factor- production. The ethanol and aqueous extracts of Hydnellum sp. were potent growth inhibitors, with a half-maximal inhibitory concentration of 0.6 mg/mL. All 5 fungi displayed strong immunostimulatory activity, whereas only L. connata and T. abietinum showed strong anti-inflammatory activity. For the 7 other fungi investigated, which included well-known medicinal species such as Inonotus obliquus, Phellinus igniarius, and Ganodermaapplanatum, the remarkable similarities in the biological activities reported here, and by others for specimens collected elsewhere, suggest that mushrooms can produce similar metabolites regardless of their habitat or ecosystem. This is to our knowledge the first study to explore wild mushrooms from British Columbia for biological activities that are relevant to cancer, and the results provide an initial framework for the selection of mushroom species with the potential for discovery of novel anticancer compounds.

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22:48

Merck Accused of Fraud, Deceit and Negligence in US Gardasil Case "IndyWatch Feed Health"

Merck's aggressive agenda to increase HPV vaccine uptake rates, despite causing thousands of severe injuries, is hitting a stumbling block in a court case alleging blatant corruption. 

There has been documented evidence that the HPV vaccine has caused more injuries than any other vaccination in history. Despite this evidence however, the HPV vaccination has continued to be hailed a success by the pharmaceutical industry and governments alike.

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22:46

Antiproliferative activity and cytotoxicity of some medicinal wood-destroying mushrooms from Russia. "IndyWatch Feed Health"

PMID:  Int J Med Mushrooms. 2018 ;20(1):1-11. PMID: 29604909 Abstract Title:  Antiproliferative Activity and Cytotoxicity of Some Medicinal Wood-Destroying Mushrooms from Russia. Abstract:  We analyzed the antiproliferative activity of 6 medicinal wood-destroying mushrooms (Fomes fomentarius, Fomitopsis pinicola, Trametes versicolor, Trichaptum biforme, Inonotus obliquus, and Coniophora puteana) that are common in deciduous and mixed coniferous forests in Central Russia. Morphological identification of strains collected from the wild was confirmed based on ribosomal DNA internal transcribed spacer phylogenetic analysis. We observed cytotoxic and cell growth-inhibitory effects of hot water extracts from mycelial biomass of 5 species-T. versicolor, C. puteana, F. fomentarius, F. pinicola, and I. obliquus-on leukemia cell lines (Jukart, K562, and THP-1); the effective extract concentrations were mostly less than 50g mL-1. However, we observed no antiproliferative activity of dry biomass from methanol-chloroform (1:1) extracts of C. puteana and F. fomentarius. A chemosensitivity assay showed that the most effective polypore mushroom extract was the methanol extract of T. versicolor (strain It-1), which inhibited the growth of 6 various solid tumors (A-549 and SWi573 [lung], HBL-100 and T-47D [breast], HeLa [cervix], and WiDr [colon]) at concentrations below 45 g mL-1, with a concentration as low as 0.7-3.6 g mL-1 causing 50% reduction in the proliferation of cancer cells in lung and cervixtumors. Methanol extracts of F. pinicola and I. obliquus were less effective, with proliferation-inhibiting capacities at concentrations below 70 and 200 g mL-1, respectively. Thus, T. versicolor is a prospective candidate in the search for and production of new antiproliferative chemical compounds.

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22:40

Effect of betulinic acid and its ionic derivatives on M-MuLV replication. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2018 Apr 13. Epub 2018 Apr 13. PMID: 29660337 Abstract Title:  Effect of betulinic acid and its ionic derivatives on M-MuLV replication. Abstract:  Murine leukemia virus (MuLV) is a retrovirus known causing leukemia and neurological disorders in mice, and its viral life cycle and pathogenesis have been investigated extensively over the past decades. As a natural antiviral agent, betulinic acid is a pentacyclic triterpenoid that can be found in the bark of several species of plants (particularly the white birch). One of the hurdles for betulinic acid to release its antiviral potency is its poor water solubility. In this study, we synthesized more water-soluble ionic derivatives of betulinic acid, and examined their activities against Moloney MuLV (M-MuLV). The mouse fibroblast cells stably infected with M-MuLV, 43D cells, were treated with various doses of betulinic acids and its derivatives, and the viral structural protein Gag in cells and media were detected by western blots. Two ionic derivatives containing the benzalkonium cation were found to inhibit the virus production into media and decreased Gag in cells. However, a cell proliferation assay showed that the benzalkonium cation inhibited the growth of 43D cells, suggesting that our ionic derivatives limited virus production through the inhibition of metabolism in 43D cells. Interestingly, all of these betulinic acid compounds exhibited a minimum impact on the processing and release of Gag from 43D cells, which outlines the differences of viral maturation between MuLV and human immunodeficiency virus.

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22:35

French Chaga contains betulin and betulinic acid at higher levels than in other Chaga. "IndyWatch Feed Health"

PMID:  Integr Cancer Ther. 2018 Feb 1:1534735418757912. Epub 2018 Feb 1. PMID: 29484963 Abstract Title:  Chaga ( Inonotus obliquus), a Future Potential Medicinal Fungus in Oncology? A Chemical Study and a Comparison of the Cytotoxicity Against Human Lung Adenocarcinoma Cells (A549) and Human Bronchial Epithelial Cells (BEAS-2B). Abstract:  BACKGROUND: Inonotus obliquus, also known as Chaga, is a parasitic fungus growing on birches and used in traditional medicine (especially by Khanty people) to treat various health problems. In this study, we aimed to quantify the 3 metabolites frequently cited in literature, that is, betulin, betulinic acid, and inotodiol in the Chaga recently discovered in forests located in Normandy (France), and to compare their concentrations with Ukrainian and Canadian Chaga. This study also explores the cytotoxicity of the French Chaga against cancer-derived cells and transformed cells.METHODS: A quantification method by HPLC-MS-MS (high-performance liquid chromatography-tandem mass spectrometry) of betulin, betulinic acid, and inotodiol was developed to study the French Chaga and compare the concentration of these metabolites with extracts provided from Chaga growing in Canada and Ukraine. This method was also used to identify and quantify those 3 compounds in other traditional preparations of Chaga (aqueous extract, infusion, and decoction). Among these preparations, the aqueous extract that contains betulin, betulinic acid, and inotodiol was chosen to evaluate and compare its cytotoxic activity toward human lung adenocarcinoma cells (A549 line) and human bronchial epithelial cells (BEAS-2B line).RESULTS: French Chaga contains betulin and betulinic acid at higher levels than in other Chaga, whereas the concentration of inotodiol is greater in the Canadian Chaga. Moreover, the results highlighted a cytotoxic activity of the Chaga's aqueous extract after 48 and 72 hours of exposure with a higher effect on cancer-derived cells A549 than on normal transformed cells BEAS-2B ( P = 0.025 after 48 hours of exposure and P = 0.004 after 72 hours of exposure).

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22:29

Suppressive effects of neonatal bisphenol A on the neuroendocrine system. "IndyWatch Feed Health"

PMID:  Toxicol Ind Health. 2018 Jan 1:748233718757082. Epub 2018 Jan 1. PMID: 29656705 Abstract Title:  Suppressive effects of neonatal bisphenol A on the neuroendocrine system. Abstract:  The aim of this study was to assess the effects of neonatal bisphenol A (BPA) administration on neuroendocrine features (the thyroid-brain axis). BPA (20 or 40g/kg) was orally administered to juvenile male albino rats ( Rattus norvegicus) from postnatal days (PNDs) 15 to 30. Both doses resulted in lower serum thyroxine (T4), triiodothyronine (T3), and growth hormone levels and higher thyrotropin level than the control levels at PND 30. In the neonatal cerebellum and cerebrum, vacuolation, pyknosis, edema, degenerative changes, and reductions in the size and number of the cells were observed in both treated groups. Alternatively, elevations in oxidative markers (lipid peroxidation, nitric oxide, and hydrogen peroxide [HO]) at both dose levels were recorded at PND 30, along with decreased activities of antioxidant markers (ascorbic acid, total thiol [t-SH], glutathione, glutathione peroxidase, glutathione reductase, glutathione-S-transferase, and catalase) with respect to control levels. Thus, the BPA-induced hypothyroid state may disturb the neonatal thyroid-brain axis via production of free radicals, and this could damage the plasma membrane and cellular components, delaying cerebrum and cerebellum development.

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22:00

Dr. Ron Unfiltered Uncensored Episode 254 WiFi-EMF with Guest Dr. Talmor "IndyWatch Feed Health"

Dr Ron whio is a Fellow of the American Academy of Family Practice and a Charter member of the American Academy of Emergency Medicine and a licinsed Acupucturist is joined by Dr Gerry and Dr Dan to host this weeky podcast on the latest medical news and information We are not influenced by Big Pharma and will give you honest opinions on the news, medical devices and we have teriffic guests. We have over 150 years of combined medical experience and are grateful to share it with you.  You can hear us  on blogtalkradio, stitcher, iTunes, GooglePlay, Alexa and others. Reach us live at 347-989-8899   Dr. Talmor graduated from Hadassah Medical school in Jerusalem in 1974 and now practices holistic medicine in Gainesville, Florida. He is board certified in Pediatrics and board eligible in Emergency Medicine. ? Dr. Talmor has utilized body-mind techniques in his medical practice as a pediatrician and as an emergency room physician since 1976. He taught personal growth classes to inmates in the Florida prison system from 1985 to 1991. He worked extensively and instructed individuals and groups in the use of consciousness and personal growth in self healing.

21:50

Apical meristems: the plant's fountain of youth. "IndyWatch Feed Health"

PMID:  Bioessays. 2003 Oct ;25(10):961-70. PMID: 14505363 Abstract Title:  Apical meristems: the plant's fountain of youth. Abstract:  During postembryonic development, all organs of a plant are ultimately derived from a few pluripotent stem cells found in specialized structures called apical meristems. Here we discuss our current knowledge about the regulation of plant stem cells and their environments with main emphasis on the shoot apical meristem of Arabidopsis thaliana. Recent studies suggest that stem cells are localized in specialized niches where signals from surrounding cells maintain their undifferentiated state. In the shoot meristem, initiation of stem cells during embryogenesis, regulation of stem-cell homeostasis and termination of stem-cell maintenance during flower development appear to primarily involve regulation of the stem-cell niche.

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21:22

Bee venom therapy: Potential mechanisms and therapeutic applications. "IndyWatch Feed Health"

PMID:  Toxicon. 2018 Apr 11. Epub 2018 Apr 11. PMID: 29654868 Abstract Title:  Bee venom therapy: Potential mechanisms and therapeutic applications. Abstract:  Bee venom is a very complex mixture of natural products extracted from honey bee which contains various pharmaceutical properties such as peptides, enzymes, biologically active amines and nonpeptide components. The use of bee venom into the specific points is so called bee venom therapy, which is widely used as a complementary and alternative therapy for 3000 years. A growing number of evidence has demonstrated the anti-inflammation, the anti-apoptosis, the anti-fibrosis and the anti-arthrosclerosis effects of bee venom therapy. With these pharmaceutical characteristics, bee venom therapy has also been used as the therapeutic method in treating rheumatoid arthritis, amyotrophic lateral sclerosis, Parkinson's disease, Alzheimer's disease, liver fibrosis, atherosclerosis, pain and others. Although widely used, several cases still reported that bee venom therapy might cause some adverse effects, such as local itching or swelling. In this review, we summarize its potential mechanisms, therapeutic applications, and discuss its existing problems.

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21:13

Plant stem cell niches: standing the test of time. "IndyWatch Feed Health"

PMID:  Cell. 2008 Feb 22 ;132(4):553-7. PMID: 18295573 Abstract Title:  Plant stem cell niches: standing the test of time. Abstract:  Similar to animal stem cells, plant stem cells require special niche microenvironments to continuously generate the tissues that constitute the plant body. Recent work using computer modeling and live imaging is helping to elucidate some of the mechanisms responsible for the specification and maintenance of stem cells in the root and shoot.

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21:09

Plant stem cell niches: from signalling to execution. "IndyWatch Feed Health"

PMID:  Curr Opin Plant Biol. 2011 Feb ;14(1):4-9. Epub 2010 Aug 23. PMID: 20739214 Abstract Title:  Plant stem cell niches: from signalling to execution. Abstract:  The shoot and root meristems contain small populations of stem cells that constantly renew themselves while providing precursor cells to build all other plant tissues and organs. Cell renewal, growth and differentiation in the meristems are co-ordinated by networks of transcription factors and intercellular signals. The past two years have revealed how auxin and cytokinin signals are integrated with each other and with regulatory genes in the shoot and root meristems. Small RNAs have also emerged as novel intercellular signals. Downstream of meristem regulatory genes, links have been made to cell division control and chromatin function. Protection of genome integrity, partly through programmed cell death after DNA damage, has recently been revealed as a specialised function in plant stem cells.

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21:07

Sculpting the meristem: the roles of miRNAs in plant stem cells. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2011 Jun 10 ;409(3):363-6. Epub 2011 May 6. PMID: 21570951 Abstract Title:  Sculpting the meristem: the roles of miRNAs in plant stem cells. Abstract:  The whole structure of higher plants is generated dynamically throughout the life cycle by the activity of stem cell niches at the apex of shoot and root. Hormone molecules and many transcription factors cooperate to balance the stem cell maintenance and differentiation. It is becoming increasingly clear that microRNA (miRNA) molecules are also participants in these processes. Here, we highlight the advances that have been made in regarding the roles of miRNAs in plant stem cell control. These advances provide a framework for our understanding of how signals are integrated to specify and position the stem cell niches in plants.

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21:05

Argonautes compete for miR165/166 to regulate shoot apical meristem development. "IndyWatch Feed Health"

PMID:  Curr Opin Plant Biol. 2012 Dec ;15(6):652-8. Epub 2012 Jun 21. PMID: 22727764 Abstract Title:  Argonautes compete for miR165/166 to regulate shoot apical meristem development. Abstract:  Plant stem cells in the shoot apical meristem (SAM) possess the unique abilities of both self-renewal for SAM maintenance and providing undifferentiated daughter cells for initiation and subsequent development of aerial organs. The coordination between stem cell renewal and cell differentiation during organogenesis is regulated by elaborate genetic pathways involving numerous transcription factors and other molecules. In the past decade, microRNAs (miRNAs) have emerged as pivotal regulators in many biological processes including meristem homeostasis and differentiation in plants. In this review, we summarize current knowledge about the function and mechanism of a family of miRNAs (miR165/166), the miRNA-designated Argonautes (AGOs), and the miRNA-regulated targets in SAM development and maintenance.

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21:04

Hormonal regulation of stem cell maintenance in roots. "IndyWatch Feed Health"

PMID:  J Exp Bot. 2013 Mar ;64(5):1153-65. Epub 2012 Nov 25. PMID: 23183258 Abstract Title:  Hormonal regulation of stem cell maintenance in roots. Abstract:  During plant embryogenesis, the apical-basal axis is established and both the shoot apical meristem (SAM) and the root apical meristem (RAM) are formed. In both meristems, there are slowly dividing cells which control the differentiation of their surrounding cells called the organizing centre (OC) and the quiescent centre (QC) in the shoot and root, respectively. These centres with their surrounding initial cells form a 'stem cell niche'. The initial cells eventually differentiate into various plant tissues, giving rise to plant organs such as lateral shoots, flowers, leaves, and lateral roots. Plant hormones are important factors involved in the balance between cell division and differentiation such that plant growth and development are tightly controlled in space and time. No single hormone acts by itself in regulating the meristematic activity in the root meristem. Division and differentiation are controlled by interactions between several hormones. Intensive research on plant stem cells has focused on how cell division is regulated to form specific plant organs and tissues, how differentiation is controlled, and how stem cell fate is coordinated. In this review, recent knowledge pertaining to the role of plant hormones in maintaining root stem cells including the QC is summarized and discussed. Furthermore, we suggest diverse approaches to answering the main question of how root stem cells are regulated and maintained by plant hormones.

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21:02

A quiescent path to plant longevity. "IndyWatch Feed Health"

PMID:  Trends Cell Biol. 2014 Aug ;24(8):443-8. Epub 2014 Apr 3. PMID: 24704103 Abstract Title:  A quiescent path to plant longevity. Abstract:  The giant sequoia and the bristlecone pine trees are capable of living up to several hundreds or even thousands of years. Plants achieve this longevity by regenerating stem cells capable of giving rise to all differentiated cells. Plant stem cells reside in specific niches with high mitotic activity that are known as meristems. Remarkably, at the center of the root stem cell niche (SCN) resides a group of mitotically inactive cells known as the quiescent center (QC). Recent studies suggest that stress-related phytohormones and DNA damage can initiate QC cell division, resulting in the replenishment of stem cells surrounding the QC. We therefore propose that the QC represents a pool of backup cells that serve to replace damaged stem cells, thereby contributing to plant longevity.

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21:00

Commentary: Plant and animal stem cells: similar yet different. "IndyWatch Feed Health"

PMID:  Nat Rev Mol Cell Biol. 2014 May ;15(5):301-12. PMID: 24755933 Abstract Title:  Plant and animal stem cells: similar yet different. Abstract:  The astonishingly long lives of plants and their regeneration capacity depend on the activity of plant stem cells. As in animals, stem cells reside in stem cell niches, which produce signals that regulate the balance between self-renewal and the generation of daughter cells that differentiate into new tissues. Plant stem cell niches are located within the meristems, which are organized structures that are responsible for most post-embryonic development. The continuous organ production that is characteristic of plant growth requires a robust regulatory network to keep the balance between pluripotent stem cells and differentiating progeny. Components of this network have now been elucidated and provide a unique opportunity for comparing strategies that were developed in the animal and plant kingdoms, which underlie the logic of stem cell behaviour.

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20:59

Molecule mechanism of stem cells in Arabidopsis thaliana. "IndyWatch Feed Health"

PMID:  Pharmacogn Rev. 2014 Jul ;8(16):105-12. PMID: 25125883 Abstract Title:  Molecule mechanism of stem cells in Arabidopsis thaliana. Abstract:  Plants possess the ability to continually produce new tissues and organs throughout their life. Unlike animals, plants are exposed to extreme variations in environmental conditions over the course of their lives. The vitality of plants is so powerful that they can survive several hundreds of years or even more making it an amazing miracle that comes from plant stem cells. The stem cells continue to divide to renew themselves and provide cells for the formation of leaves, stems, and flowers. Stem cells are not only quiescent but also immortal, pluripotent and homeostatic. Stem cells are the magic cells that repair tissues and regenerate organs. During the past decade, scholars around the world have paid more and more attention toward plant stem cells. At present, the major challenge is in relating molecule action mechanism to root apical meristem, shoot apical meristem and vascular system. The coordination between stem cells maintenance and differentiation is critical for normal plant growth and development. Elements such as phytohormones, transcription factors and some other known or unknown genes cooperate to balance this process. In this review, Arabidopsis thaliana as a pioneer system, we highlight recent developments in molecule modulating, illustrating how plant stem cells generate new mechanistic insights into the regulation of plants growth and development.

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20:58

[On plant stem cells and animal stem cells]. "IndyWatch Feed Health"

PMID:  Zhongguo Zhong Yao Za Zhi. 2014 Jan ;39(2):343-5. PMID: 24761658 Abstract Title:  [On plant stem cells and animal stem cells]. Abstract:  A comparison of plant and animal stem cells can highlight core aspects of stem-cell biology. In both kingdoms, stem cells are defined by their clonogenic properties and are maintained by intercellular signals. The signaling molecules are different in plants and animals stem cell niches, but the roles of argonaute and polycomb group proteins suggest that there are some molecular similarities.

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20:56

Pesticides Are Making Children Aggressive "IndyWatch Feed Health"

Pesticides Children Aggressive, Time for an Overhaul

By Evaggelos Vallianatos

Pesticides cause a multitude of adverse effects  on humans. However, they are especially harmful to children. They may have something to do with the mass-shootings in schools all over America because some of them are neurotoxins. This means they affect and damage the central nervous system and the brain of all animals, including humans.

SEE: Is Monsanto Contributing To The Rise In Mass Shootings?

Warren Porter, professor emeritus of zoology at the University of Wisconsin, conducted experiments with ground water water drawn from the ground of farms with typical levels of pesticides and fertilizers. He chose farm water contaminated with the insecticide aldicarb, the herbicide atrazine, and nitrogen fertilizer. He tested that mixture on white mice and deer mice.

The concentrations of the fertilizer with each of the pesticides (aldicarb and atrazine) in the ground water were of the order of magnitude the Environmental Protection Agency says the chemicals cause no unreasonable harm to man and the environment.

...

20:55

Sugar in the diet may increase risks of opioid addiction "IndyWatch Feed Health"

Sugar in the diet may increase risks of opioid addiction

By Francesco Leri, University of Guelph

Could a diet high in refined sugars make children and adults more susceptible to opioid addiction and overdose? New research, from our laboratory of behavioral neuroscience at the University of Guelph, suggests it could.

Approximately 20,000 people died of fentanyl-related overdoses in the United States last year and in Canada there were at least 2,816 opioid-related deaths. During 2017 so far, over 1,000 people have died of illicit drug overdoses in British Columbia. High schools are stocking up on the overdose-reversing drug naloxone and universities are training staff to administer the drug.

Nobody is talking about sugar.

And yet there is substantial experimental evidence that refined sugar can promote addictive behaviours by activating the brains rewards centres in much the same way as addictive drugs. Opioid abuse is also associated with poor dietary habits, including preferences for sugar-rich foods, as well as malnutrition. These connections have led to questions of whether excessive consumption of refined sugar may affect vulnerability to opioid addiction.

...

20:53

Mental Illness Label Used to Medically Kidnap Mother and Try to Adopt Out Her Children "IndyWatch Feed Health"

Tara and daughter

Tara Chapman was doing great with her family when she was seized, handcuffed, and ultimately locked up in a psych facility. Photo provided by family.

by Health Impact News/MedicalKidnap.com Staff

Tara Chapman, a 33 year old disabled mother, was handcuffed, drugged, and carted away to a facility that is 8 hours from her family. She is being held prisoner in Tennessee under the guise of mental illness, even though a mental hospital in Virginia recently said that she did not meet the criteria to commit her.

The state of Tennessee wants Taras three boys to stay in foster care, away from family. The family wants to know how far the state is willing to go to ensure that neither Tara nor her family gets her 3 children back? A fourth child, Taras daughter, is being cared for by her mother Whitney, the childrens grandmother, but the state refuses to allow the grandmother to care for the 3 boys.

There was supposed to be a court hearing on Friday, April 13, 2018, but the juvenile court cancelled it without warning less than 24 hours before.

Tara has suffered from mild mental illness for many years, but it was only after her children were seized by Child Protective Services and abused in foster care that her mental health deteriorated to the point where she qualified for disability.

See original story, reported in January:

Tennessee Kidnaps 3 Boys from Mentally Disabled Mom Refuses Grandmother Custody in Favor of Adoption to Strangers

Mental Illness Symptoms Disappear after Weening off of Psych Drugs

She was recently home with family members in Virginia for almost 3 weeks before she was medically kidnapped. During that time, her mother Whitney Manning was able to ween her off of the psychotropic medications.

The change in Tara was almost miraculous. Whitney found that the symptoms in her daughter that they had been led to believe were due to her mental illness disappeared. She stopped hallucinating. The crazy tal...

20:53

Plant stem cells as innovation in cosmetics. "IndyWatch Feed Health"

PMID:  Acta Pol Pharm. 2014 Sep-Oct;71(5):701-7. PMID: 25362798 Abstract Title:  Plant stem cells as innovation in cosmetics. Abstract:  The stem cells thanks to their ability of unlimited division number or transformation into different cell types creating organs, are responsible for regeneration processes. Depending on the organism in which the stem cells exists, they divide to the plant or animal ones. The later group includes the stem cells existing in both embryo's and adult human's organs. It includes, among others, epidermal stem cells, located in the hair follicle relieves and also in its basal layers, and responsible for permanent regeneration of the epidermis. Temporary science looks for method suitable for stimulation of the epidermis stem cells, amongst the other by delivery of e.g., growth factors for proliferation that decrease with the age. One of the methods is the use of the plant cell culture technology, including a number of methods that should ensure growth of plant cells, issues or organs in the environment with the microorganism-free medium. It uses abilities of the different plant cells to dedifferentiation into stem cells and coming back to the pluripotent status. The extracts obtained this way from the plant stem cells are currently used for production of both common or professional care cosmetics. This work describes exactly impact of the plant stem cell extract, coming from one type of the common apple tree (Uttwiler Sptlauber) to human skin as one of the first plant sorts, which are used in cosmetology and esthetic dermatology.

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20:48

Vitamin C supplementation may alleviate acute inflammation in recovery phase and ameliorated subchronic inflammation in early colon cancer. "IndyWatch Feed Health"

PMID:  Nutr Res Pract. 2018 Apr ;12(2):101-109. Epub 2018 Mar 22. PMID: 29629026 Abstract Title:  Effect of vitamin C on azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced colitis-associated early colon cancer in mice. Abstract:  BACKGROUND/OBJECTIVES: The objective of this study was to investigate the effects of vitamin C on inflammation, tumor development, and dysbiosis of intestinal microbiota in an azoxymethane (AOM)/dextran sulfate sodium (DSS)-induced inflammation-associated early colon cancer mouse model.MATERIALS/METHODS: Male BALB/c mice were injected intraperitoneally with AOM [10 mg/kg body weight (b.w)] and given two 7-d cycles of 2% DSS drinking water with a 14 d inter-cycle interval. Vitamin C (60 mg/kg b.w. and 120 mg/kg b.w.) was supplemented by gavage for 5 weeks starting 2 d after the AOM injection.RESULTS: The vitamin C treatment suppressed inflammatory morbidity, as reflected by disease activity index (DAI) in recovery phase and inhibited shortening of the colon, and reduced histological damage. In addition, vitamin C supplementation suppressed mRNA levels of pro-inflammatory mediators and cytokines, including cyclooxygenase-2, microsomal prostaglandin E synthase-2, tumor necrosis factor-, Interleukin, and, and reduced expression of the proliferation marker, proliferating cell nuclear antigen, compared to observations of AOM/DSS animals. Although the microbial composition did not differ significantly between the groups, administration of vitamin C improved the level of inflammation-relatedandto control levels.CONCLUSION: Vitamin C treatment provided moderate suppression of inflammation, proliferation, and certain inflammation-related dysbiosis in a murine model of colitis associated-early colon cancer. These findings support that vitamin C supplementation can benefit colonic health. Long-term clinical studies with various doses of vitamin C are warranted.

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20:43

Involvement of Plant Stem Cells or Stem Cell-Like Cells in Dedifferentiation. "IndyWatch Feed Health"

PMID:  Front Plant Sci. 2015 ;6:1028. Epub 2015 Nov 18. PMID: 26635851 Abstract Title:  Involvement of Plant Stem Cells or Stem Cell-Like Cells in Dedifferentiation. Abstract:  Dedifferentiation is the transformation of cells from a given differentiated state to a less differentiated or stem cell-like state. Stem cell-related genes play important roles in dedifferentiation, which exhibits similar histone modification and DNA methylation features to stem cell maintenance. Hence, stem cell-related factors possibly synergistically function to provide a specific niche beneficial to dedifferentiation. During callus formation in Arabidopsis petioles, cells adjacent to procambium cells (stem cell-like cells) are dedifferentiated and survive more easily than other cell types. This finding indicates that stem cells or stem cell-like cells may influence the dedifferentiating niche. In this paper, we provide a brief overview of stem cell maintenance and dedifferentiation regulation. We also summarize current knowledge of genetic and epigenetic mechanisms underlying the balance between differentiation and dedifferentiation. Furthermore, we discuss the correlation of stem cells or stem cell-like cells with dedifferentiation.

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20:30

Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2015 Oct ;39(4):376-83. Epub 2015 Apr 30. PMID: 26869831 Abstract Title:  Protective effect of wild ginseng cambial meristematic cells on d-galactosamine-induced hepatotoxicity in rats. Abstract:  BACKGROUND: Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against d-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals.METHODS: Hepatotoxicity was induced in rats using GalN (700 mg/kg, i.p.). Wild ginseng CMCs was administered orally once a day for 2 wks, and then 2 h prior to and 6 h after GalN injection.RESULTS: Wild ginseng CMCs attenuated the increase in serum aminotransferase activity that occurs 24 h after GalN injection. Wild ginseng CMCs also attenuated the GalN-induced increase in serum tumor necrosis factor-, interleukin-6 level, and hepatic cyclooxygenase-2 protein and mRNA expression. Wild ginseng CMCs augmented the increase in serum interleukin -10 and hepatic heme oxygenase-1 protein and mRNA expression that was induced by GalN, inhibited the increase in the nuclear level of nuclear factor-kappaB, and enhanced the increase in NF-E2-related factor 2.CONCLUSION: Our findings suggest that wild ginseng CMCs protects liver against GalN-induced inflammation by suppressing proinflammatory mediators and enhancing production of anti-inflammatory mediators.

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20:28

An epidermis-driven mechanism positions and scales stem cell niches in plants. "IndyWatch Feed Health"

PMID:  Sci Adv. 2016 Jan ;2(1):e1500989. Epub 2016 Jan 29. PMID: 27152324 Abstract Title:  An epidermis-driven mechanism positions and scales stem cell niches in plants. Abstract:  How molecular patterning scales to organ size is highly debated in developmental biology. We explore this question for the characteristic gene expression domains of the plant stem cell niche residing in the shoot apical meristem. We show that a combination of signals originating from the epidermal cell layer can correctly pattern the key gene expression domains and notably leads to adaptive scaling of these domains to the size of the tissue. Using live imaging, we experimentally confirm this prediction. The identified mechanism is also sufficient to explain de novo stem cell niches in emerging flowers. Our findings suggest that the deformation of the tissue transposes meristem geometry into an instructive scaling and positional input for the apical plant stem cell niche.

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20:27

Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants. "IndyWatch Feed Health"

PMID:  Sci China Life Sci. 2016 Aug ;59(8):825-31. Epub 2016 Aug 10. PMID: 27502904 Abstract Title:  Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants. Abstract:  BARD1 (BRCA1 associated RING domain protein 1), as an important animal tumor suppressor gene associated with many kinds of cancers, has been intensively studied for decades. Surprisingly, homolog of BARD1 was found in plants and it was renamed AtROW1 (repressor of Wuschel-1) according to its extremely important function with regard to plant stem cell homeostasis. Although great advances have been made in human BARD1, the function of this animal tumor-suppressor like gene in plant is not well studied and need to be further elucidated. Here, we review and summarize past and present work regarding this protein. Apart from its previously proposed role in DNA repair, recently it is found essential for shoot and root stem cell development and differentiation in plants. The study of AtROW1 in plant may provide an ideal model for further elucidating the functional mechanism of BARD1 in mammals.

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20:25

Review: Plant Stem Cells. "IndyWatch Feed Health"

PMID:  Curr Biol. 2016 09 12 ;26(17):R816-21. PMID: 27623267 Abstract Title:  Plant Stem Cells. Abstract:  Among the trending topics in the life sciences, stem cells have received a fair share of attention in the public debate - mostly in connection with their potential for biomedical application and therapies. While the promise of organ regeneration and the end of cancer have captured our imagination, it has gone almost unnoticed that plant stem cells represent the ultimate origin of much of the food we eat, the oxygen we breathe, as well the fuels we burn. Thus, plant stem cells may be ranked among the most important cells for human well-being. Research by many labs in the last decades has uncovered a set of independent stem cell systems that fulfill the specialized needs of plant development and growth in four dimensions. Surprisingly, the cellular and molecular design of these systems is remarkably similar, even across diverse species. In some long-lived plants, such as trees, plant stem cells remain active over hundreds or even thousands of years, revealing the exquisite precision in the underlying control of proliferation, self-renewal and differentiation. In this minireview, we introduce the basic features of the three major plant stem cell systems building on these facts, highlight their modular design at the level of cellular layout and regulatory underpinnings and briefly compare them with their animal counterparts.

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20:20

Redox regulation of plant stem cell fate. "IndyWatch Feed Health"

PMID:  EMBO J. 2017 10 2 ;36(19):2844-2855. Epub 2017 Aug 24. PMID: 28838936 Abstract Title:  Redox regulation of plant stem cell fate. Abstract:  Despite the importance of stem cells in plant and animal development, the common mechanisms of stem cell maintenance in both systems have remained elusive. Recently, the importance of hydrogen peroxide (HO) signaling in priming stem cell differentiation has been extensively studied in animals. Here, we show that different forms of reactive oxygen species (ROS) have antagonistic roles in plant stem cell regulation, which were established by distinct spatiotemporal patterns of ROS-metabolizing enzymes. The superoxide anion (O2-) is markedly enriched in stem cells to activateand maintain stemness, whereas HOis more abundant in the differentiating peripheral zone to promote stem cell differentiation. Moreover, HOnegatively regulates O2- biosynthesis in stem cells, and increasing HOlevels or scavenging O2- leads to the termination of stem cells. Our results provide a mechanistic framework for ROS-mediated control of plant stem cell fate and demonstrate that the balance between O2- and HOis key to stem cell maintenance and differentiation.

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20:19

Plant stem cells in cosmetics: current trends and future directions. "IndyWatch Feed Health"

PMID:  Future Sci OA. 2017 Nov ;3(4):FSO226. Epub 2017 Jul 12. PMID: 29134115 Abstract Title:  Plant stem cells in cosmetics: current trends and future directions. Abstract:  Plant regeneration at the cellular and tissue level is a unique process. Similar to animals, the stem cells in plants have properties that help stimulate and regenerate plants after injury. The unique properties of plant stem cells have been a recent area of interest and focus both in developing new cosmetics and studying how these extracts/phytohormones will influence animal skin. This special report focuses on the current evidence-based trends in plant stem cell-based cosmetics and sheds light on the challenges that we need to overcome in order to see meaningful changes in human skin using topical cosmetics derived from plant stem cells.

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20:17

Mental Illness Label Used to Medically Kidnap Mother and Try to Adopt Out Her Children "IndyWatch Feed Health"

Tara and daughter

Tara Chapman was doing great with her family when she was seized, handcuffed, and ultimately locked up in a psych facility. Photo provided by family.

by Health Impact News/MedicalKidnap.com Staff

Tara Chapman, a 33 year old disabled mother, was handcuffed, drugged, and carted away to a facility that is 8 hours from her family. She is being held prisoner in Tennessee under the guise of mental illness, even though a mental hospital in Virginia recently said that she did not meet the criteria to commit her.

The state of Tennessee wants Taras three boys to stay in foster care, away from family. The family wants to know how far the state is willing to go to ensure that neither Tara nor her family gets her 3 children back? A fourth child, Taras daughter, is being cared for by her mother Whitney, the childrens grandmother, but the state refuses to allow the grandmother to care for the 3 boys.

There was supposed to be a court hearing on Friday, April 13, 2018, but the juvenile court cancelled it without warning less than 24 hours before.

Tara has suffered from mild mental illness for many years, but it was only after her children were seized by Child Protective Services and abused in foster care that her mental health deteriorated to the point where she qualified for disability.

See original story, reported in January:

Tennessee Kidnaps 3 Boys from Mentally Disabled Mom Refuses Grandmother Custody in Favor of Adoption to Strangers

Mental Illness Symptoms Disappear after Weening off of Psych Drugs

She was recently home with family members in Virginia for almost 3 weeks before she was medically kidnapped. During that time, her mother Whitney Manning was able to ween her off of the psychotropic medications.

The change in Tara was almost miraculous. Whitney found that the symptoms in her daughter that they had been led to believe were due to her mental illness disappeared. She stopped hallucinating. The crazy talk c...

20:13

White mulberry supplementation as adjuvant treatment of obesity. "IndyWatch Feed Health"

PMID:  J Biol Regul Homeost Agents. 2014 Jan-Mar;28(1):141-5. PMID: 24750800 Abstract Title:  White mulberry supplementation as adjuvant treatment of obesity. Abstract:  Body weight is controlled by our genes and managed by a neuro-hormonal system, in particular by insulin and glucagon. The meristematic extract of Japanese white mulberry blocks the alpha-glucosidase and then the intestinal hydrolysis of polysaccharides, thereby reducing the glycaemic index of carbohydrates. The target of our research was to evaluate the adjuvant slimming effect of the extract of white Japanese mulberry in the dietetic treatment of some patients who are obese or overweight. 46 overweight people were enrolled and divided into two subgroups: the subjects of both subgroups were given an identical balanced diet of 1300 kcal: subjects of the subgroup alpha received 2400 mg of white Japanese mulberry extract, the subgroup b subjects receive placebo. Each subgroup was followed-up every 30 days at 30, 60 and 90 days of treatment. Both in the periodic inspections and in the final inspection measurements of body weight and waist circumference in all the subjects and thigh circumference in women only were repeated. All subjects repeated blood tests. In the subgroup alpha, weight loss was about 9 kg in 3 months, equal to approximately 10 percent of the initial weight, significantly higher than subgroup beta (P

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20:10

Review: Plant natural products: history, limitations and the potential of cambial meristematic cells. "IndyWatch Feed Health"

PMID:  Biotechnol Genet Eng Rev. 2012 ;28:47-59. PMID: 22616481 Abstract Title:  Plant natural products: history, limitations and the potential of cambial meristematic cells. Abstract:  Humans have utilised plant derived natural products as medicines for millenia. Moreover, many contemporary pharmaceuticals are also natural products or derivatives thereof. However, the full potential of these compounds remains to be exploited because often they are: complex and difficult to synthesise; found in low quantities; produced by undomesticated and sometimes rare plants; and, their synthesis is routinely influenced by weather conditions. Potentially, the in vitro culture of cells from the corresponding plant species could circumvent some of these problems but the growth of plant cells on an industrial scale is also problematic. The recent isolation and culture of cambial meristematic cells (CMCs), stem cells which ordinarily generate the plant vasculature, may now provide a key platform technology to help realise the full potential of plant natural products.

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20:10

Melanization of a meristematic mutant of Fonsecaea monophora increases tolerance to stress factors while no effects on antifungal susceptibility. "IndyWatch Feed Health"

PMID:  Mycopathologia. 2011 Nov ;172(5):373-80. Epub 2011 Jun 26. PMID: 21706309 Abstract Title:  Melanization of a meristematic mutant of Fonsecaea monophora increases tolerance to stress factors while no effects on antifungal susceptibility. Abstract:  Melanin is a complex polymer, which is widely distributed in nature, and is known as an important virulence factor in opportunistic and pathogenic fungi. In this study, three melanin mutants of Fonsecaea monophora from a case of chromoblastomycosis were generated from a parent strain that lacked hyphal morphology but was meristematic instead. Two albino mutants, one of which (CBS 125187) produced secreted melanin and another (CBS 125149) lacked melanin, grew faster than a mutant with cell-wall-associated and secreted melanin (CBS 125188) and than the meristematic parent strain (CBS 122845) (P 

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20:08

Red cabbage anthocyanin extract alleviates copper-induced cytological disturbances in plant meristematic tissue and human lymphocytes. "IndyWatch Feed Health"

PMID:  Biometals. 2009 Jun ;22(3):479-90. Epub 2009 Jan 19. PMID: 19152114 Abstract Title:  Red cabbage anthocyanin extract alleviates copper-induced cytological disturbances in plant meristematic tissue and human lymphocytes. Abstract:  Red cabbage is a source of health beneficial substances with antioxidant and antigenotoxic properties. HPLC analysis specifying the content of the investigated extract indicated that mainly anthocyanins (ATH) were responsible for its abilities. Cytological research was conducted with two experimental models: plant tissues--meristematic cells of Vicia faba, and animal tissue elements--human lymphocytes. Positive influence of ATH extract on mitotic activity of Vicia cells exposed to Cu(2+) stress, and inhibitory effect of ATH on cytotoxic actions of Cu(2+) on lymphocytes were demonstrated. In all experimental series with ATH application in combinations with Cu(2+), mitotic index (MI) were higher than those obtained for only Cu(2+) stressed tissues. Preincubation in ATH before Cu(2+) stress had the best effect. Similarly, after ATH applications in all tested series decrease in frequency of micronuclei (MN) appearance was noticed in comparison with only Cu(2+) stressed material. In the case of Vicia cells ATH acted effectively even applied after Cu(2+) stress. It suggests that this ATH mixture not only prevents and limits but also heals the cytological injury caused by Cu(2+) stress.

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19:55

I Mistook Myself for a Scientific Label by Dr. Peter Gordon "IndyWatch Feed Health"

This is neither fact
nor expert advice:

I am an artist, a poet, and all that may be in-between.

This is neither fact
nor expert advice:

Specialisms are making nonsense of sense.

We are being divided.

*****

Back to poetry

19:55

Animal study confirms Kratom's traditional use as anti-diarrhea agent. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2008 Feb 28 ;116(1):173-8. Epub 2007 Nov 28. PMID: 18191353 Abstract Title:  Inhibitory effects of kratom leaf extract (Mitragyna speciosa Korth.) on the rat gastrointestinal tract. Abstract:  Kratom (Mitragyna speciosa Korth.) is an indigenous plant of Thailand used traditionally in folk medicine although it is claimed to cause addiction. It is used to treat diarrhea, however, there is no scientific evidence to support the use. The aim of this study is to investigate the effect of methanolic extract of kratom leaves on the rat gastrointestinal tract. Kratom extract at 50, 100, 200 and 400 mg/kg (p.o.) caused a dose dependent protection against castor oil-induced diarrhea in rats and also inhibited intestinal transit. The antidiarrheal effect was not antagonized by naloxzone. The inhibition of intestinal transit by kratom extract was significantly different from the control when treated with a single dose for 1 day. For longer-term treatments of 15 and 30 days, kratom extract did not decrease the intestinal transit time indicating that adaptation had occurred. Kratom extract at a dose level of 200 and 400 mg/kg for 30 days and morphine at 3 mg/kg (i.p.) caused a decrease in the increment of body weight that was significantly different from the control and kratom extract at lower doses (50 and 100 mg/kg). However it had no effect on the level of plasma cholecystokinin. The results suggested that methanolic kratom extract exhibited its antidiarrheal effect on rat gastrointestinal tract. The effects may occur via pathways in addition to the action on opioid receptors. High does of kratom extract decreased the increment of body weight similar to the effect of morphine.

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19:51

Review: available data currently suggest both, a therapeutic as well as an abuse potential. "IndyWatch Feed Health"

PMID:  Neurosci Biobehav Rev. 2013 Feb ;37(2):138-51. Epub 2012 Dec 1. PMID: 23206666 Abstract Title:  From Kratom to mitragynine and its derivatives: physiological and behavioural effects related to use, abuse, and addiction. Abstract:  Kratom (or Ketum) is a psychoactive plant preparation used in Southeast Asia. It is derived from the plant Mitragyna speciosa Korth. Kratom as well as its main alkaloid, mitragynine, currently spreads around the world. Thus, addiction potential and adverse health consequences are becoming an important issue for health authorities. Here we reviewed the available evidence and identified future research needs. It was found that mitragynine and M. speciosa preparations are systematically consumed with rather well defined instrumentalization goals, e.g. to enhance tolerance for hard work or as a substitute in the self-treatment of opiate addiction. There is also evidence from experimental animal models supporting analgesic, muscle relaxant, anti-inflammatory as well as strong anorectic effects. In humans, regular consumption may escalate, lead to tolerance and may yield aversive withdrawal effects. Mitragynine and its derivatives actions in the central nervous system involve-opioid receptors, neuronal Ca channels and descending monoaminergic projections. Altogether, available data currently suggest both, a therapeutic as well as an abuse potential.

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19:44

Chronic kratom administration does not significantly impair social functioning of users in a natural context in Malaysia. "IndyWatch Feed Health"

PMID:  J Psychoactive Drugs. 2015 Apr-Jun;47(2):125-31. PMID: 25950592 Abstract Title:  Social Functioning of Kratom (Mitragyna speciosa) Users in Malaysia. Abstract:  Kratom (Mitragyna speciosa) is an indigenous plant known for its traditional medicinal use, and for its addiction potential, in Southeast Asia. In recent years, kratom and its major alkaloid, mitragynine, spread worldwide with largely unknown effects on behavior and mental health. Recent studies show that kratom use can lead to dependence and that mitragynine works as an addictive drug in animal studies. Nevertheless, kratom preparations were also suggested as a less harmful substitute in opiate withdrawal. Potential side-effects of prolonged kratom use, however, are currently unclear. The aim of this study was to investigate the social functioning of regular kratom users in Malaysia. A cross-sectional survey was carried out in three northern states of Peninsular Malaysia investigating 293 regular kratom consumers using the Addiction Severity Index in a snowball sampling technique. Findings showed that regular kratom users do not experience major impairments in their social functioning, despite being dependent on kratom for prolonged periods. Our findings suggest that chronic kratom administration does not significantly impair social functioning of users in a natural context in Malaysia.

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19:43

Pharmacokinetics of mitragynine (kratom biochemical) in man. "IndyWatch Feed Health"

PMID:  Drug Des Devel Ther. 2015 ;9:2421-9. Epub 2015 Apr 29. PMID: 25995615 Abstract Title:  Pharmacokinetics of mitragynine in man. Abstract:  BACKGROUND: Kratom, known botanically as Mitragyna speciosa (Korth.), is an indigenous tree in Southeast Asia. Kratom is currently easily available worldwide via special shops and the Internet to use as a drug of abuse, opioid alternative, or pain killer. So far, the pharmacokinetics of this plant has been studied only in animals, and there is no such study in humans. The major abundant active alkaloid in Kratom, mitragynine, is one of the promising new chemical substances to be developed as a new drug. The aim of this study was to examine the pharmacokinetics of mitragynine and assess the linearity in pharmacokinetics in chronic users.METHODS: Since Kratom is illegal in Thailand, studies in healthy subjects would be unethical. We therefore conducted a prospective study by enrolling ten chronic, regular, healthy users. We adjusted the steady state in each subject by giving a known amount of Kratom tea for 7 days before commencement of the experiment. We admitted and gave different oral doses to subjects to confirm linearity in pharmacokinetics. The mitragynine blood concentrations at 17 times points and the urine concentrations during the 24-hour period were collected and measured by liquid chromatography-tandem mass spectrometry method.RESULTS: Ten male subjects completed the study without adverse reactions. The median duration of abuse was 1.75 years. We analyzed one subject separately due to the abnormal behavior of blood concentration. From data of nine subjects, the pharmacokinetic parameters established were time to reach the maximum plasma concentration (0.830.35 hour), terminal half-life (23.2416.07 hours), and the apparent volume of distribution (38.0424.32 L/kg). The urine excretion of unchanged form was 0.14%. The pharmacokinetics were observed to be oral two-compartment model.CONCLUSION: This was the first pharmacokinetic study in humans, which demonstrated linearity and was consistent with the oral two-compartment model with a terminal half-life of about 1 day. The pharmacokinetic linearity and parameters reported are necessary pharmacological information of Kratom, and there is a possibility for it to be developed medically as a pain killer or better opioid substitute in the future.

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19:42

Experiences of Kratom Users: A Qualitative Analysis. "IndyWatch Feed Health"

PMID:  J Psychoactive Drugs. 2015 Nov-Dec;47(5):360-7. Epub 2015 Nov 23. PMID: 26595229 Abstract Title:  Experiences of Kratom Users: A Qualitative Analysis. Abstract:  Kratom (Mitragyna speciosa) is a psychoactive plant that has been used since at least 1836 in folk medicine in Southeast Asian countries. More recently, kratom has become widely available in the West and is used for both recreational and medicinal purposes. There has, however, been little scientific research into the short- and long-term effects of kratom in humans, and much of the information available is anecdotal. To supplement the increasing scientific understanding of kratom's pharmacology and research into its effects in animals, we report the results of a qualitative analysis of first-hand descriptions of human kratom use that were submitted to, and published by, a psychoactive substance information website (Erowid.org). Themes that emerged from these experience reports indicate that kratom may be useful for analgesia, mood elevation, anxiety reduction, and may aid opioid withdrawal management. Negative response themes also emerged, indicating potential problems and unfavorable"side"effects, especially stomach upset and vomiting. Based on our analyses, we present preliminary hypotheses for future examination in controlled, quantitative studies of kratom.

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19:36

Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. "IndyWatch Feed Health"

n/a PMID:  Front Pharmacol. 2017 ;8:96. Epub 2017 Feb 28. PMID: 28293192 Abstract Title:  Indole Alkaloids from Plants as Potential Leads for Antidepressant Drugs: A Mini Review. Abstract:  Depression is the most common illness observed in the elderly, adults, and children. Antidepressants prescribed are usually synthetic drugs and these can sometimes cause a wide range of unpleasant side effects. Current research is focussed on natural products from plants as they are a rich source of potent new drug leads. Besides(St. John's wort), the plants studied includeL. (passion flower),(kratom),G. Forst (kava) andL. Harman, harmol, harmine, harmalol and harmaline are indole alkaloids isolated from, while mitragynine is isolated from. The structure of isolated compounds fromG. Forst andL. contains an indole moiety. The indole moiety is related to the neurotransmitter serotonin which is widely implicated for brain function and cognition as the endogenous receptor agonist. An imbalance in serotonin levels may influence mood in a way that leads to depression. The moiety is present in a number of antidepressants already on the market. Hence, the objective of this review is to discuss bioactive compounds containing the indole moiety from plants that can serve as potent antidepressants.

19:35

A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth: Implications for products sold as kratom. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2017 Apr 18 ;202:302-325. Epub 2017 Mar 19. PMID: 28330725 Abstract Title:  A botanical, phytochemical and ethnomedicinal review of the genus Mitragyna korth: Implications for products sold as kratom. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: The genus Mitragyna (Rubiacaeae) has been traditionally used in parts of Africa, Asia and Oceania. In recent years, there has been increased interest in species of Mitragyna with the introduction of products to western markets and regulatory uncertainty.AIM OF THE STUDY: This paper reviewed the traditional ethnomedicinal uses of leaves for species belonging to the genus Mitragyna with reference to the botany and known chemistry in order to highlight areas of interest for products currently being sold as kratom.MATERIALS AND METHODS: A literature search was conducted using Web of Science, Google Scholar, the Royal Museum for Central Africa, Internet Archive, Hathi Trust, and Biodiversity Heritage Library search engines in the spring of 2015, fall of 2016 and winter of 2017 to document uses of bark, leaf and root material.RESULTS: Leaves of M. speciosa (kratom) had the most common documented ethnomedicinal uses as an opium substitute or remedy for addiction. Other species of Mitragyna were reportedly used for treating pain, however the mode of preparation was most often cited as topical application. Other uses of Mitragyna included treatment of fever, skin infections, and as a mild anxiolytic.CONCLUSIONS: Mitragyna species have been used medicinally in various parts of the world and that there is significant traditional evidence of use. Modern products that include formulations as topical application of liniments, balms or tinctures may provide effective alternatives for treatment of certain types of pains. Future research is required to establish safety and toxicology limits, medicinal chemistry parameters and the potential for different physiological responses among varying genetic populations to support regulatory requirements for Mitragyna spp.

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19:33

Kratom as a pharmacological tool to mitigate withdrawal symptoms is related to its action on KOR. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2017 Jun 9 ;205:178-185. Epub 2017 May 10. PMID: 28501425 Abstract Title:  The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Mitragyna speciosa and its extracts are called kratom (dried leaves, extract). They contain several alkaloids with an affinity for different opioid receptors. They are used in traditional medicine for the treatment of different diseases, as a substitute by opiate addicts, and to mitigate opioid withdrawal symptoms. Apart from their medical properties, they are used to enhance physical endurance and as a means of overcoming stress.PURPOSE: The aim of this study was to determine the mechanisms underlying the effects of kratom on restraint-stress-induced analgesia which occurs during or following exposure to a stressful or fearful stimulus.METHODS: To gain further insights into the action of kratom on stress, we conducted experiments using restraint stress as a test system and stress-induced analgesia as a test parameter. Using transgenic mu opioid-receptor (MOR) deficient mice, we studied the involvement of this receptor type. We used nor-binaltorphimine (BNT), an antagonist at kappa opioid receptors (KOR), to study functions of this type of receptor. Membrane potential assay was also employed to measure the intrinsic activity of kratom in comparison to U50,488, a highly selective kappa agonist.RESULTS: Treatment with kratom diminished stress-induced analgesia in wildtype and MOR knockout animals. Pretreatment of MOR deficient mice with BNT resulted in similar effects. In comparison to U50,488, kratom exhibited negligible intrinsic activity at KOR alone.CONCLUSIONS: The results suggest that the use of kratom as a pharmacological tool to mitigate withdrawal symptoms is related to its action on KOR.

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19:26

Kratom appears to provide a safer alternative than opioids for pain management. "IndyWatch Feed Health"

PMID:  Drug Alcohol Depend. 2018 Feb 1 ;183:134-140. Epub 2017 Dec 7. PMID: 29248691 Abstract Title:  Kratom use and mental health: A systematic review. Abstract:  BACKGROUND: Kratom (Mitragyna speciosa) is a psychoactive plant native to Southeastern Asia that is receiving increased international attention as a potential therapeutic agent. While much of the limited scientific research on kratom is focused on its analgesic potential, kratom use also has important risks and benefits in the domain of mental health.METHODS: We conducted a comprehensive systematic review of all studies on kratom use and mental health published between January 1960 and July 2017.RESULTS: Findings indicate kratom's potential as a harm reduction tool, most notably as a substitute for opioids among people who are addicted. Kratom also enhances mood and relieves anxiety among many users. For many, kratom's negative mental health effects - primarily withdrawal symptoms - appear to be mild relative to those of opioids. For some users, however, withdrawal is highly uncomfortable and maintaining abstinence becomes difficult.CONCLUSION: Results inform clinicians working in the mental health and substance use fields, policy-makers, and researchers about the mental health effects of this plant.

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19:04

Appendicitis Off The Grid "IndyWatch Feed Health"

Appendicitis Off The Grid After a disaster or at a remote homestead, the medic may not have ready access to modern medical technology. As such, many conditions that are commonly identified with ultrasounds or CAT scans may be more challenging to diagnose. One of these challenges is abdominal pain. There are various medical issues that cause it, with the classic example of an abdominal emergency being appendicitis. Over 300,000 Americans have their appendix removed every year. The Appendix The vermiform

[... Continue Reading]

18:50

Youth Guru loses turkey-neck paper that overlapped with book chapter "IndyWatch Feed Health"

A prominent cosmetic surgeon and his daughter have lost a 2017 paper on treating men with excessive neck flab otherwise known as turkey neck because much of the work appears to have duplicated a book chapter he co-authored about the topic. The first author of the retracted article is Ronald L. Moy, a Continue reading Youth Guru loses turkey-neck paper that overlapped with book chapter

18:13

Light at Night can Disrupt Circadian Rhythms in Children Are There Long-Term Risks? "IndyWatch Feed Health"

By Richard G. Bugs Stevens, University of Connecticut

A new scientific study shows that bright electric light exposure of preschool children in the evening suppresses melatonin production almost completely, an important addition to the growing body of research in this area. Melatonin suppression is a marker of disruption of our circadian rhythms.

Ten kids, ages 3 to 5, were exposed to bright light (~1000 lux from a light box) for one hour before their habitual bedtime, about 8 p.m. Melatonin suppression (where the body stops producing this hormone) began within 10 minutes and continued for another hour after the bright light was turned off at 8 p.m., which was well into their usual sleep period. Melatonin is a hormone that is important for healthy circadian rhythms and good sleep.

This could undoubtedly reduce sleep quality, but may also cause other serious problems in the longer term.

When seeing the light can be bad

The new study built upon a...

17:57

Gene Therapy and the Trans-Human Agenda Cure disease or Alter Humans? "IndyWatch Feed Health"

By Jon Rappoport

Researchers say theyre well on the way to curing thousands of diseases by tinkering with human genes. But is that true? Or is their effort really part of a long-range agenda to keep experimenting in the dark, through grotesque trial and error, to alter humans and make them into a new species? (The Underground, Jon Rappoport)

With the onrush of new gene-editing techniques, the medical research establishment is beating an old drum: they will cure many human diseases by making genetic changes.

First of all, the new editing techniques have unknown consequences. A simple snip of a gene can bring on ripples in the patients overall genetic structure. This fact spells danger.

Second, and here is the old drum: there are a number of diseases caused by a problem with a single geneone gene, one disease. Therefore, a precise edit of the offending gene will cure the disease.

But is this one-gene one-disease hypothesis actually true?

If so, we should already have seen these cures. But we havent.

Im not talking about the occasional claim of a single cure in a single patient. Im talking about curing a specific disease across the...

17:08

Environmentalists and Farmers Seek Court Decision Halting Use of Dows Agent Orange Pesticide "IndyWatch Feed Health"

Environmentalists and Farmers Seek Court Decision Halting Use of Dows 'Agent Orange' Pesticide

By Earthjustice

Late [last] Wednesday, a coalition of environmental organizations and farmers represented by the Center for Food Safety (CFS) and Earthjustice filed new legal papers in federal court seeking the reversal of Scott Pruitt and the Trump Environmental Protection Agencys (EPA) approval of Dow Chemicals toxic pesticide, Enlist Duo. The novel pesticide is a combination of glyphosate and 2,4-D, to be sprayed over the top of corn, cotton and soybeans that are genetically engineered by Dow with resistance to both pesticides.

Our filing reveals that EPA approved Enlist Duo despite its significant harms to health, environment, farms, water, and endangered species, said Sylvia Wu, CFS attorney and counsel for the coalition. EPAs job is protecting the environment, human health, and farmers, not blindly do the bidding of pesticide companies. The court must stop its use.

...

16:51

New Paper Challenges HHS on their Vaccine Aluminum Dosing Safety Numbers "IndyWatch Feed Health"

By Ginger Taylor Remember a lifetime ago when we figured out that not only did the US Childhood vaccine schedule dramatically exceeded the Federal government's recommended daily limit for mercury, but that the limit that they had set was likely...

14:00

Dont like a paper, but dont want to retract it? Just issue an editorial statement "IndyWatch Feed Health"

Last April, the American Journal of Epidemiology and the American Journal of Public Health published a rare joint editorial statement. It concerned a pair of papers on the topic of mortality and obesity. Several complaints had prompted the journals to investigate. Their assessment: These papers contained inaccurate results. The statement was not a retractionit was Continue reading Dont like a paper, but dont want to retract it? Just issue an editorial statement

12:19

Why All Diabetics Should Know About Turmeric "IndyWatch Feed Health"

Why All Diabetics Should Know About Turmeric

Many diabetics already know about the benefits of a low-glycemic diet and the need for regular exercise, but why haven't they heard about turmeric, one of the world's most extensively researched anti-diabetic plants?

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12:02

Is Curing Patients a Sustainable Business Model? "IndyWatch Feed Health"

From CNBC: A recent report by Goldman Sachs analysts questions whether curing patients, as opposed to providing them with chronic therapies, could pose a financial risk for biotech companies.

The potential to deliver one shot cures is one of the most attractive aspects of gene therapy, genetically-engineered cell therapy and gene editing. However, such treatments offer a very different outlook with regard to recurring revenue versus chronic therapies, analyst Salveen Richter wrote in the note to clients Tuesday. While this proposition carries tremendous value for patients and society, it could represent a challenge for genome medicine developers looking for sustained cash flow.'

Article 

12:01

Im Withdrawing From Antidepressants After Nearly 20 Years "IndyWatch Feed Health"

From The Lily: In light of the recent New York Times article highlighting the effects antidepressant withdrawal, Ashley Abramson shares her personal story of deciding to come off antidepressants after taking them for almost 20 years.

Each decrease feels like a jolt to my brain and body. Im dizzy, tired, agitated and sometimes nauseous. The withdrawal symptoms sometimes feel like too much to deal with, and it would definitely be easier to go back on the full dose.

But like running a long race, Ive made painful progress, and I dont want to turn back.

The question is: What will I find at the finish line?

Article 

12:00

Bright Light Therapy More Effective Than Medication Alone for Bipolar Depression "IndyWatch Feed Health"

A new randomized, double-blind, placebo-controlled trial has found bright light therapy to be a powerful intervention that could provide an alternative to medication for people with bipolar depression. Two-thirds of the people receiving the light therapy improved, compared with one-fifth of those who took only medication. The research was led by Dorothy Sit at Northwestern University and published in the American Journal of Psychiatry.

The study included people who had a diagnosis of either bipolar I or bipolar II disorder, but who were not currently meeting criteria for a manic or hypomanic episode. All participants were taking antimanic medication, also known as mood stabilizers (e.g. lithium).

Many (78.3%) of the participants were also taking antidepressant medications, and the researchers made sure that both the control group and the intervention group had similar numbers of people taking these drugs. All participants also met criteria for continuing depression, despite their current medication regimen.

One group of 23 participants was exposed to 7000-lux bright white light daily, between noon and 2:30 pm. They initially began at 15 minutes of light use, then gradually increased to the target dose of 60 minutes per day at week 4. The other group received a placebo light intervention that was described as 50-lux dim red light.

The difference in improvement is startling. 68.2% of people who received the bright light intervention no longer met criteria for depression (what researchers refer to as remission), compared with only 22.2% who received a placebo light intervention.

This difference was not due simply to an improvement in sleep quality, as sleep was observed to improve equally for both groups. There was no difference in side effects between the two groups, indicating that light therapy did not create any additional adverse events. No one experienced a hypomanic or manic episode.

The improvement in depressive symptoms appeared to occur between weeks 4-6 for most participants, which the researchers theorize is due to reaching the 60-minute per day dose of light at week 4 (see graph below).

Particularly surprising is that, despite most participan...

11:31

David Kirby's New Book: When They Come for You "IndyWatch Feed Health"

David Kirby's book on the trampling of constitutional rights: A harrowing tale of American injustice - and Americans fighting back against it. by Ginger Taylor "The nine most terrifying words in the English language are, 'I'm from the government and...

07:14

Tooth decay sparks move to add fluoride to Darlingtons water "IndyWatch Feed Health"

A MOVE to introduce a mineral to the water supply in a town where more than a third of five-year-olds have one or more decayed, filled or missing teeth has been revealed.

Some 63 years after being invited to take part in a five-year trial to test the benefits of adding fluoride to the water supply, Darlingtons council looks set to be urged to do so by one of its committees.

When it rejected the scheme in 1955 members of Darlington Town Council said they feared they were making a mistake, but residents did not all want fluoride in their water.

Seven years later, the Ministry of Health published the studys results, which found there had been a substantial improvement in the teeth of young children in the areas which agreed to the study and no evidence of harm from fluoridation had been discovered.

At a meeting of the councils children and young people scrutiny committee members heard a proposal to introduce fluoride to the towns water supply was being drawn up following a study which exposed stark differences between childrens oral health between areas where the mineral is or is not in drinking water.

Members were told childrens oral health was also closely linked to deprivation, but there were huge differences between the economically similar areas of Darlington and Hartlepool, where the latter has fluoride naturally in the water.

Councillor Anne-Marie Curry said fluoridated water was the least intrusive way of helping people look after their teeth.

She told the meeting: There is still a feeling that there should be a choice. If they dont want the fluoridated water we should suggest they filter it or drink bottled water.

Last year, Dr John Furness, a consultant paediatrician based at Darlington Memorial Hospital, said despite weekly extraction clinics for youngsters in the region, councils were refusing to pay for the fluoride to water because of the cost involved.

Durham County Council has heard while 61 per cent of children were suffering decay in the Woodhouse Close area of Bishop Auckland, just six per cent were in the Chester-le-Street South division, where fluoride has been added to the water supply since the 1960s, at a cost of around 50,000 a year.

However, campaigners say there is no conclusive evidence about the benefits of adding the mineral to the water supply.

After being told about the possible move in Darlington, Professor of Health Policy at Kent University Stephen Peckham said schemes which had seen NHS staff support families were far more effective than fluoridation....

07:00

More Trouble for Organic Products "IndyWatch Feed Health"

By Dr. Mercola

Carrageenan, a food additive extracted from red seaweed, is commonly added as a thickening agent to processed foods, particularly dairy products, certain deli meats and other prepared foods. Since it comes from seaweed, many people assume carrageenan is natural perhaps even healthy and along with conventional foods this additive is often found in natural and organic products.

The problem is that carrageenan is not nutritious, nor is it natural or certified organic. Its a processed additive extracted from seaweed using alkali, and research suggests its highly inflammatory, triggering an immune reaction that may cause inflammation in your gastrointestinal system and related problems.1 As such, organic watchdog groups such as The Cornucopia Institute have called for it to be removed from the U.S. list of approved organic ingredients.

In December 2016, the National Organic Standards Board (NOSB), the U.S. Department of Agricultures (USDA) expert advisory board, voted to do just that. After hearing evidence on the potential health risks and the availability of alternative ingredients, NOSB voted to remove carrageenan from the organic ingredients list. Unfortunately, the vote is technically only a recommendation, and while the USDA has historically almost always sided with their expert panel, in April 2018 they did just the opposite.

USDA Overrules NOSB Advice, Keeps Carrageenan in Organics

The USDA decided to reapprove carrageenan for organic foods, saying in a statement in the Federal Register:2

AMS [USDA's Agricultural Marketing Service] has reviewed NOSB's sunset review document and decided to renew all 17 substances, including carrageenan. AMS found sufficient evidence in public comments to the NOSB that carrageenan continues to be necessary for handling agricultural products because of the unavailability of wholly natural substitutes

Carrageenan has specific uses in an array of agricultural products, and public comments reported that potential substitutes do not adequately replicate the functions of carrageenan across the broad scope of use.

Yet, as noted by Mark A. Kastel, senior farm policy analyst at the Cornucopia Institute, the decision flies in the face of the very reason NOSB was created. This is the latest instance of the   administration...

Privilege of Knowledge and the Duty to Act on Pesticides "IndyWatch Feed Health"

By Dr. Mercola

Though he still sees himself as just a little boy who loves frogs, Tyrone Hayes, Ph.D., an integrative biologist at the University of California, Berkeley, has spent a decade feuding with chemical giant Syngenta, manufacturer of the pesticide atrazine. Novartis, which eventually became Syngenta, asked Hayes to use his extensive knowledge of frog hormones to determine if atrazine was interfering with frogs in the environment.

It certainly wasnt what they wanted to hear, but he found atrazine may be chemically castrating male frogs, essentially turning them into female frogs. When Hayes reported some of his troubling findings to the U.S. Environmental Protection Agency (EPA), including male frogs with eggs bursting out of their testicles I thought they would be interested, after all it was the No. 1 selling chemical in the world at the time, he said they stated it wasnt an adverse effect that would prompt them to reevaluate the chemical.

Hayes resigned his contractor position with Syngenta after the company refused to allow him to publish the results of studies they had funded. After resigning, he obtained independent funding to repeat the research, which was subsequently published and found that atrazine causes hermaphroditism in frogs.

Syngenta attempted to discredit Hayes after the damaging research was released. However, as Hayes argues in the TED talk above, he follows Albert Einsteins notion that those who have the privilege to know, have the duty to act.

Atrazine Shown To Be Harmful to Animals, Humans and the Environment

Hayes research hypothesized that atrazine turned on an enzyme (aromatase) that caused testosterone to be converted into estrogen. If youre a male, this means that you wont make sperm, but you will make estrogen, even though you shouldnt.

According to Hayes and colleagues in research published in Nature in 2002, exposure to water-borne atrazine contamination led to gonadal abnormalities such as retarded development and hermaphroditism in 10 percent to 92 percent of male wild leopard frogs. Hayes published another study in 2010 in Proceedings of the National Academy of Sciences (PNAS), which similarly found:1

Atrazine-exposed males suffered from depressed testosterone, decreased breeding gland size, demasculinized/feminized laryngeal development, suppressed mating behavior, reduced sper...

Rare Gene That Confers Drug Resistance Between Bacteria Now Found in 27 States "IndyWatch Feed Health"

By Dr. Mercola

According to the largest review of the drug resistance problem to date, by 2050 the annual global death toll from antibiotic-resistant disease will reach 10 million.1 At present, an estimated 23,000 Americans die each year from drug-resistant infections, and the death toll will continue to rise until or unless the underlying causes are properly addressed. One significant driver of antibiotic-resistant bacteria is the routine use of antibiotics in agriculture.2

As noted by the Institute for Agriculture and Trade Policy in 2016,3 "The rapid spread of new disease strains ... is one very visible reason why the expansion of factory-style animal production is viewed as unsustainable." In the video above, the late Steve Wing, former associate professor and epidemiologist at the University of North Carolina at Chapel Hill, discusses the human health impacts of factory farms.

Another major contributor to and source of drug-resistant infections is hospitals. According to statistics by the Centers for Disease Control and Prevention (CDC), 1 in 25 patients now contracts a hospital-acquired infection4 and many of them are resistant to drug treatment. Most disturbing of all, some infections are now exhibiting "panresistance," meaning they're resistant to every antibiotic in existence.

One particularly nasty panresistant bacterium that is gaining ground is carbapenem-resistant enterobacteriaceae (CRE), which produces an enzyme that breaks down antibiotics. Hospitals are the most common source of this infection, which is lethal in about 9 percent of all cases. When the CRE infection affects the blood, the death rate jumps to 50 percent.5

CRE With Rare New Resistance-Conferring Genes Found in 27 States

Tests conducted last year on nearly 5,780 antibiotic-resistant bacterial samples collected from hospitals and nursing homes revealed 1 in 4 samples contained genes known to confer drug resistance, and 221 contained a particularly rare drug-resistance gene that confers a very high level of resistance.6,...

Video: The Left's War on Christ "IndyWatch Feed Health"

This video details the Left's flagrant attacks on Christians. Whether it be attacks against Chick-Fil-A, Mike Pompeo, or Christian bakers, those of the left have proven that they are intolerant of Christianity.

You may watch this on YouTube if there are any problems watching the video at this site. It can also be viewed at Bit Chute.

06:58

FAN Gets an Exciting Picture From Canada and Another Huge Pledge From a US Benefactor "IndyWatch Feed Health"

Currently our total stands at $49,364 from 331 donors. Thanks to everyone who has donated so far and for everything else you and they are doing to end the reckless practice of water fluoridation.

The TSCA lawsuit* against the EPA has sparked three creative ways to increase money for the legal fund.

The first flare of creativity comes from David Green in Ontario, who sent us this photo of his effort. His local group is Fluoride Free Peterborough. David is a partner, with his brother Ian, in Rocky Ridge Drinking Water Limited. David says, No $50 bills in the bottle yet, but the coins are accumulating.

The second is a challenge is from one of FANs long-time benefactors

  • Will donate $250 when we reach 350 donors,
  • Will donate $500 when we reach 400 donors,
  • Will donate $750 when we reach 450 donors, and
  • Will donate $1500 when we reach 500 donors!

The third is also a challenge from yet another long-time (since the 1970s) fluoridation fighter, who firmly believes that this lawsuit is our best chance ever of ending fluoridation worldwide.

  • Will donate $5,000 if we can get another 100 (from the current 331) supporters to donate $10 or more online.
  • And will donate ANOTHER (!) $5000 if we can get another 100 people who donate $5 or more by check.We all agree that we need more numbers of people on our team to win this lawsuit.

Our goal is to raise $75,000 by May 31. If we make that deadline then we have another generous benefactor and a non-profit organization that have each pledged to donate $75,000 to yield a healthy legal fighting fund of $225,000. Ideally, we would like the burden to be shared by a 1000 people.

How to donate

  • Online at our secure server.
  • Or by Check, payable to the Fluoride Action Network. Send your check to:
    Fluoride Action Network
    c/o Connett
    104  Walnut Street
    Binghamton NY 13905
  • ...

05:37

Dunedin: Council gets ticking off over bill "IndyWatch Feed Health"

Margaret van Zyl is still waiting for her money.

The Mosgiel pensioner turned up at the Dunedin City Councils infrastructure and networks committee meeting yesterday to voice her displeasure during the public forum.

She was upset by the councils continuing practice of adding fluoride to drinking water, in line with Ministry of Health guidelines.

And she was also upset at the councils decision to switch the source of Mosgiels water from an untreated bore to the citys fluoridated supply in December, following public health advice.

But, most of all, she was miffed by the councils refusal to pay for the $240 water filter she bought and had installed after Mosgiels water supply changed.

Mrs van Zyl told yesterdays meeting she had sent the bill the council, but received a response from council chief executive Sue Bidrose declining to cover the cost.

Not good enough, Mrs van Zyl told councillors.

I expect to be paid. Your cheque, I hope, will be in the post.

*Original article online at https://www.odt.co.nz/news/dunedin/dcc/council-gets-ticking-over-bill

04:07

Greater dietary vitamin C intake was associated with a lower risk of hip fracture and osteoporosis "IndyWatch Feed Health"

PMID:  Br J Nutr. 2018 Apr ;119(8):847-858. PMID: 29644950 Abstract Title:  Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies. Abstract:  We aimed to systematically review available data on the association between vitamin C intake and bone mineral density (BMD), as well as risk of fractures and osteoporosis, and to summarise this information through a meta-analysis. Previous studies on vitamin C intake in relation to BMD and risk of fracture and osteoporosis were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases before February 2017, using MeSH and text words. To pool data, either a fixed-effects model or a random-effects model was used, and for assessing heterogeneity, Cochran's Q and I 2 tests were used. Subgroup analysis was applied to define possible sources of heterogeneity. Greater dietary vitamin C intake was positively associated with BMD at femoral neck (pooled r 018; 006, 030) and lumbar spine (pooled r 014; 95 % CI 006, 022); however, significant between-study heterogeneity was found at femoral neck: I 2=876 %, P heterogeneity

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03:43

Ascorbic acid attenuates multifidus muscles injury and atrophy after posterior lumbar spine surgery. "IndyWatch Feed Health"

PMID:  Spine (Phila Pa 1976). 2018 Apr 11. Epub 2018 Apr 11. PMID: 29649092 Abstract Title:  Ascorbic Acid Attenuates Multifidus Muscles Injury and Atrophy after Posterior Lumbar Spine Surgery by Suppressing Inflammation and Oxidative Stress in a Rat Model. Abstract:  STUDY DESIGN: A rat model of multifidus muscles injury and atrophy after posterior lumbar spine surgery.OBJECTIVE: We determined the effect of ascorbic acid (AA) on the postoperative multifidus muscles in rat model.SUMMARY OF BACKGROUND DATA: Previous studies show oxidative stress and inflammation are two main molecular mechanisms in multifidus muscle injury and atrophy after posterior lumbar surgery. AA may have a protective effect in postoperative multifidus muscles.METHODS: Rats were divided into sham surgery, control surgery, and surgery plus AA groups. Multifidus muscles of the control and AA groups were excised from the osseous structures. The muscles were retracted continuously for 2h. In the sham and AA groups, AA was administered via oral gavage daily in the first week. In each group, the oxidative stress was evaluated by measuring malondialdehyde (MDA) and Total superoxide dismutase (T-SOD). The inflammation, fat degeneration or fibrosis of multifidus muscle were evaluated by Q-PCR, histology or immunohistochemical analysis.RESULTS: T-SOD activity was significantly lower in the control group than that in the AA group in the first week. MDA levels were significantly higher in the AA group. Interleukin-6 and tumor necrosis factor- in multifidus muscles also showed significant differences when treated with AA. The inflammation score on histology was significantly lower in the AA group postoperatively in the first week. In the long run, marker genes for fibrosis and fat degeneration, and fibrosis and fat degeneration scores,were significantly lower in the AA than the control group on days 14 and 28 postoperatively.CONCLUSIONS: In conclusion, AA attenuated the oxidative stress and inflammation response in the postoperative multifidus muscles, and remarkable differences were observed from the histological assessment and related marker genes expression. Our results provided important insight into the anti-inflammatory and anti-oxidative effects of AA in the postoperative multifidus muscles.LEVEL OF EVIDENCE: N/A.

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03:10

This research indicated that taraxasterol and dandelion extract has anti-crystallization activities. "IndyWatch Feed Health"

PMID:  Ren Fail. 2018 Nov ;40(1):298-305. PMID: 29619876 Abstract Title:  Inhibitory effects of taraxasterol and aqueous extract of Taraxacum officinale on calcium oxalate crystallization: in vitro study. Abstract:  OBJECTIVE: We investigated and compared the effects of taraxasterol, aqueous extract of T. officinale (AET) aerial part, and potassium citrate (PC) on calcium oxalate (CaOx) crystallization in vitro.MATERIALS AND METHODS: CaOx crystallization was induced by adding sodium oxalate to synthetic urine. Taraxasterol (2.5, 5, 7.5 and 12.5g/mL), extract (1, 2, 4 and 8mg/mL), and PC (100, 150, 200 and 350mg/mL) were subjected to anti-crystallization activities. The absorbance and %inhibition of nucleation of CaOx crystals were evaluated by spectrophotometer at 2, 4, 6, 8, 10, 20, 30, 40, 50 and 60min and the number and morphology of crystals were studied by light microscopy after 60min.RESULTS: Presence of taraxasterol, extract and PC decreased absorbance in experimental samples compared to control, significantly. The nucleation of crystals is inhibited by taraxasterol, extract, and PC (26-64, 55-63 and 60-70%, respectively). The number of CaOx crystals were decreased in presence of taraxasterol (p

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02:33

Carbohydrate ingestion from bananas had positive influence in attenuating metabolic perturbation and inflammation following 75-km cycling. "IndyWatch Feed Health"

PMID:  PLoS One. 2018 ;13(3):e0194843. Epub 2018 Mar 22. PMID: 29566095 Abstract Title:  Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial. Abstract:  OBJECTIVES AND METHODS: Using a randomized, crossover, counterbalanced approach, cyclists (N = 20, overnight fasted state) engaged in the four 75-km time trials (2-week washout) while ingesting two types of bananas with similar carbohydrate (CHO) but different phenolic content (Cavendish, CAV; mini-yellow, MIY, 63% higher polyphenols), a 6% sugar beverage (SUG), and water only (WAT). CHO intake was set at 0.2 g/kg every 15 minutes. Blood samples were collected pre-exercise and 0 h-, 0.75 h-,1.5 h-, 3 h-, 4.5 h-, 21 h-, 45 h-post-exercise.RESULTS: Each of the CHO trials (CAV, MIY, SUG) compared to water was associated with higher post-exercise plasma glucose and fructose, and lower leukocyte counts, plasma 9+13 HODES, and IL-6, IL-10, and IL-1ra. OPLS-DA analysis showed that metabolic perturbation (N = 1,605 metabolites) for WAT (86.84.0 arbitrary units) was significantly greater and sustained than for CAV (70.43.9, P = 0.006), MIY (68.34.0, P = 0.002), and SUG (68.14.2, P = 0.002). VIP ranking (

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01:59

Extracted banana proteins showed antibacterial effects against both gram positive and gram negative bacteria. "IndyWatch Feed Health"

PMID:  J Food Sci Technol. 2018 Feb ;55(2):658-666. Epub 2017 Nov 27. PMID: 29391630 Abstract Title:  Extraction and characterization of proteins from banana () flower and evaluation of antimicrobial activities. Abstract:  Ultrasonic assisted alkaline extraction of protein from banana flower was optimized using response surface methodology. The extracted proteins were characterized by Fourier transform infrared spectroscopy and molecular weight distribution was determined by gel electrophoresis. The maximum protein yield of 252.25 mg/g was obtained under optimized extraction conditions: temperature 50 C, 30 min extraction time and 1 M NaOH concentration. The alkaline extraction produced a significantly high protein yield compared to enzymatic extraction of banana flower. Chemical finger printing of proteins showed thepresence of tyrosine, tryptophan and amide bonds in extracted protein. Alkaline and pepsin assisted extracted banana flower proteins showed characteristic bands at 40 and 10 kDA, respectively. The extracted proteins showed antibacterial effects against both gram positive and gram negative bacteria.The high protein content and antimicrobial activity indicate the potential applications of banana flower in the food and feed industry.

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01:41

The results from this study suggest the presence of significant anticonvulsant activity in M. sapientum stem extract. "IndyWatch Feed Health"

PMID:  Pharmacognosy Res. 2018 Jan-Mar;10(1):49-54. PMID: 29568187 Abstract Title:  Anticonvulsant and Antioxidant Effects ofStem Extract on Acute and Chronic Experimental Models of Epilepsy. Abstract:  Background: (banana) plant extract has been shown to possess antioxidant activity in previous studies. Neuronal injury resulting from oxidative stress is an important factor involved in pathogenesis of epilepsy.Objective: The present study aimed to evaluate the anticonvulsant activity ofstem extract (MSSE) in acute and chronic experimental models in mice and its effects on various markers of oxidative stress in the brain of pentylenetetrazole (PTZ)-kindled animals.Material and Methods: Maximal electroshock seizures (MES) and PTZ-induced convulsion models were used for acute studies. For the chronic study, the effect of MSSE on the development of kindling was studied. For the evaluation of the effects of MSSE on oxidative stress in brain, malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated in the brains of the kindled animals.Results: MSSE significantly increased the latency to onset of myoclonic jerks and the duration of clonic convulsions following PTZ administration. The MSSE pretreated group showed significantly reduced mean seizure score on PTZ-induced kindling. There was a significant increase in the brain MDA levels and decrease in GSH levels in response to PTZ-induced kindling. On MSSE pretreatment, there was a significant decrease in the MDA levels in the brains, though the increase in the GSH levels was not significant.Conclusion: The results from this study suggest the presence of significant anticonvulsant activity in MSSE, in both acute and chronic PTZ-induced seizure models, which could be due to its antioxidant activity, as is reflected by the change in oxidative stress markers in brain.SUMMARY: Evaluation of the anticonvulsant activity ofand its effects on various markers of oxidative stress in the brain has not been done previously to the best of our knowledgestem extract (MSSE) significantly increased the latency to onset of myoclonic jerks and the duration of clonic convulsions in the experimental modelsThe MSSE pretreated group showed significantly reduced mean seizure score on pentylenetetrazole (PTZ)-induced kindlingThere was significant increase in the brain malondialdehyde (MDA) levels and decrease in glutathione (GSH) levels in response to PTZ-induced kindlingOn MSSE pretreatment, there was a significant decrease in the MDA levels in the brain, though the increase in the GSH levels was not significant.MSSE:stem extract, PTZ: Pentylenetetrazole, MES: Maximal electroshock seizures, MDA: Malondialdehyde, GSH: Glutathione, SOD: Superoxide dismutase, THLE: Tonic hindlimb extension.

...

00:42

Antihyperglycemic and antidyslipidemic activity of Musa paradisiacabased diet in alloxaninduced diabetic rats. "IndyWatch Feed Health"

PMID:  Food Sci Nutr. 2018 Jan ;6(1):137-145. Epub 2017 Nov 20. PMID: 29387371 Abstract Title:  Antihyperglycemic and antidyslipidemic activity of-based diet in alloxan-induced diabetic rats. Abstract:  This study was aimed at investigating the antihyperglycemic and antidyslipidemic activity of-based diets in alloxan-induced diabetic mellitus rats. Diabetes was induced by a single intraperitoneal injection of alloxan (150 mg/kg b.w) in 48 randomly selected rats. The rats were randomly grouped into four as follows: normal rats fed-based diet, diabetic control rats fed-based diet, diabetic rats fed-based diet and administered metformin (14.2 mg/kg body weight) orally per day, and diabetic rats fed-based diet. Body weight and fasting blood glucose level were monitored, on 28th days the rats were sacrificed, liver was excised. Thereafter, the hyperglycemic and dyslipidemic statii of the induced diabetic animals were determined. The-based diet significantly (

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00:33

Climate Engineering Insanity, Manufacturing Winter Weather With Tropical Moisture "IndyWatch Feed Health"

a6e76Dane Wigington GeoengineeringWatch.org Planet Earth is being forced into an abrupt climate shift, the ongoing global climate engineering operations are further fueling the overall process. The combination satellite / radar image below reveals an extremely anomalous and alarming scenario: a massive, bizarre, and completely unnatural, straight, south to north flow of tropical moisture from the record warm waters

00:17

Flower and inflorescence stalk of M. balbisiana Colla. possess significant antidiabetic, antihyperlipidemic, and antioxidant activities. "IndyWatch Feed Health"

PMID:  Indian J Pharmacol. 2017 Jan-Feb;49(1):71-76. PMID: 28458426 Abstract Title:  Antidiabetic, antihyperlipidemic, and antioxidant activities ofColla. in Type 1 diabetic rats. Abstract:  OBJECTIVES: To evaluate the antidiabetic, antihyperlipidemic, and antioxidant activities of the ethanolic extracts of the flowers and inflorescence stalk ofColla. in streptozotocin (STZ)-induced Type 1 diabetic rats.MATERIALS AND METHODS: Diabetes was induced in male Wistar albino rats (150-200 g) by single intraperitoneal injection of STZ (60 mg/kg b.w. i.p.). Albino rats (= 25) were divided into five groups, of which five animals each. Group A (normal control) and Group B (diabetic control) received normal saline (10 ml/kg/day p.o.), whereas Group C and Group D received 250 mg/kg/day p.o. of flower and inflorescence stalk ethanolic extracts, respectively, for 2 weeks. Group E (diabetic standard) received 6 U/kg/day s.c of Neutral Protamine Hagedorn insulin. Fasting blood sugar, serum insulin, catalase (CAT), malondialdehyde (MDA), and serum lipid profile were estimated at specific intervals of time. Effect of the extracts on intestinal glucose absorption was also evaluated to know the probable mechanism of action.RESULTS: Diabetic control exhibited significant increase in blood glucose, serum cholesterol, triglycerides, low-density lipoprotein, serum MDA levels and decreased serum CAT, and high-density lipoprotein levels which were significantly reverted by flower and inflorescence stalk ethanolic extracts after 2 weeks. Serum insulin levels were in increased (

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00:09

Two banana cultivars differ in composition of potentially immunomodulatory mannan and arabinogalactan. "IndyWatch Feed Health"

PMID:  Carbohydr Polym. 2017 May 15 ;164:31-41. Epub 2017 Jan 22. PMID: 28325331 Abstract Title:  Two banana cultivars differ in composition of potentially immunomodulatory mannan and arabinogalactan. Abstract:  Banana (Musa acuminata and M. acuminata x M. balbisiana) fruit cell walls are rich in mannans, homogalacturonans and xylogalacturonan, rhamnogalacturonan-I, and arabinogalactans, certain forms of which is considered to have immunomodulatory activity. The cultivars Nanico and Thap Maeo represent two widely variants with respect to compositional differences in the forms of these polysaccharides. Nanico has low amounts of mannan in the water-insoluble and water-soluble fraction. Both cultivars have high amounts of water-soluble arabinogalactan. These commelinoidmonocots lack the (13),(14)--d-glucans of grasses, but Thap Maeo has higher amounts of non-starch glucans associated with wild species than does Nanico. High amount of callose was found in both cultivars. As immunomodulatory activity is associated with the fine structure and interaction ofthese polysaccharides, breeding programs to introgress disease resistance from wild species must account for these special structural features in retaining fruit quality and beneficial properties.

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Monday, 16 April

23:59

Pain in Base of Skull: What Headache at Base of Skull Means "IndyWatch Feed Health"

Pain or headaches at the base of your skull are often the result of tight muscles in the back of your neck due to tension, stress, or fatigue. Pain in back of head at the base of skull can also be caused by a herniated cervical disc or injury to your upper neck. Sometimes, the headaches that start at the base of the skull can be tension headaches, cluster headaches, or cervicogenic headaches.

Pain in the back of your head at the base of your skull can cause your head to hurt with dull, nagging persistent pains. If you have a trapped nerve in your cervical spine, you may experience sharp jabbing pains that radiate to your temples or behind your eye. Headaches at the back of your neck can also cause pain that travels down your spine. Neck pain at the base of your skull may also result in shoulder pain, back pain, or tingling in your arms.

In most cases, the neck pain and headaches at the back of your head go away when you get proper rest or apply home remedies. For example, applying a heat or cold pack, getting a neck or shoulder massage, or using essential oils can help to relieve a stiff neck that causes headaches.

In this article, you will find out what it means if you have a headache in the back of your head and neck. You will also find helpful ways to alleviate the pressure and tension at the base of your skull. In some cases, if the pain doesnt go away, you should see a doctor.

The Anatomy of Your Upper Spine

The upper part of your spine that joins to the base of your skull is called the cervical spine. Dr. Robert E. Windsor, who specializes in physical medicine and rehabilitation, says that the cervical spine consists of 7 vertebrae. These are referred to as C1 to C7 vertebrae. The first vertebra (C1) is called the atlas and upon which the base of the skull rests.1

The cervical spinal vertebrae are also responsible for most of the movement of your neck and head. Dr. Windsor says that the cervical spine is the most mobile part of your spine.

Intervertebral discs are located between each vertebra and these act as shock absorbers. These are round, jelly-like discs that prevent inflammation and pain in the back of your neck.

The Encyclopaedia Britannica says that you also have nerves and muscles in the back of your neck. The muscles join the top of your neck to the base of your skull. The trapezius muscles also attach your neck to your scapula (shoulder blade). There is also a system of nerves in the back of your neck, some of which form part of the spinal cord.2

...

22:59

Southern Pulled Pork Recipe (oven baked, sugar free) "IndyWatch Feed Health"

pulled pork recipes, pulled porkWhat Southerner does not love barbecue? This classic recipe for pulled pork is one of my redone favorites using healthier ingredients. It is oven baked for convenience (who has a smoker in the backyard?), but the results turn out just as tender. 

This dish is just perfect for a crowd or a chilly/rainy weekend at home.

The post Southern Pulled Pork Recipe (oven baked, sugar free) appeared first on The Healthy Home Economist.

22:05

Why Barbara Ehrenreich Is Giving Up On Preventative Care "IndyWatch Feed Health"

Do you ever feel like medical tests and screenings that are supposedly expected of you are just too much? Annual physical exams are one thing, but then you have cancer screenings, pap smears, eye exams, colonoscopies, breast exams All those appointments are done in hopes of keeping you healthy and extending your life. However, New York... View Article

The post Why Barbara Ehrenreich Is Giving Up On Preventative Care appeared first on Healthy Holistic Living.

21:53

Infrared Light and Saunas: Healing Many Illnesses "IndyWatch Feed Health"

Picture of a small wooden infrared sauna booth in a spa

Infrared sauna

by Paul Fassa
Health Impact News

Sweat lodges, dry saunas, and wet saunas (steam) have been used for healing and detoxing for several centuries. While exposing ones body to heat over an extended period of time, the activity of fever takes place, stimulating the immune system to release white blood cells to kill pathogenic microbes or destroy cancer tumor cells. (Source)

Exposing heat to the body over an extended period of time produces profuse sweating that can transport toxins out of the body. Over time, the practice of sauna bathing can even eliminate toxins and drugs trapped in lipid tissue (fat) for years.

Both functions of body heat is why more and more health practitioners are realizing that wrapping up and sweating out a bout of fever up to but not beyond 104 degrees Fahrenheit is more beneficial than suppressing it with pharmaceuticals. (Source)

Many of us cant cope with extended dry or wet sauna visits and some of us cant even access them. But there is a solution for easily obtaining the same results without the agony of enduring intense ambient heat, using infrared technology.

The Best Type of Sauna Heat is From Infrared Radiation Technology

Infrared energy frequency applications offer deeper heat penetration into body tissue with less heat, reducing ambient heat from the 160 degrees F of conventional saunas to 110 degrees. Infrared radiation is able to penetrate human tissue three inches, less or more, without burning or discomfort.

Generally, around 15 to 30 minutes inside an infrared radiation sauna is sufficient to achieve the maximum expected results of conventional dry or wet saunas that require enduring higher temperatures for considerably longer times.

Mayo Clinics Dr. Brent...

21:37

A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo. "IndyWatch Feed Health"

PMID:  Carbohydr Polym. 2015 Jun 25 ;124:157-63. Epub 2015 Feb 20. PMID: 25839806 Abstract Title:  A polysaccharide from Trametes robiniophila inhibits human osteosarcoma xenograft tumor growth in vivo. Abstract:  In the present study, we isolated and purified one polysaccharide (TRP) from Trametes robiniophila, which had a backbone of 1,3,6- and 1,4-linked glucpyranosyl moieties, with 1-linked arabinofuranosyl and galactopyranosyl terminal at the O-3 position of 1,3,6-linked glucpyranosyl residues. TRP was further evaluated for its antitumor activity against xenografted U-2 OS osteosarcoma in BALB/c nude mice together with the possible mechanism of action. We found that oral administration of TRP significantly suppressed U-2 OS tumor growth in mice via the induction of apoptosis, as evidenced by the increased number of TUNEL-positive cells in tumor tissues. Moreover, TRP administration increased the levels of the proapoptotic Bax protein and decreased the level of the antiapoptotic Bcl-2 protein, thus resulting in a rise of Bax/Bcl-2 ratio. Furthermore, the protein expression of caspase-9, caspase-3 and cleaved PARP became evident in tumor tissues from mice following TRP treatment, but caspase-8 keep unchanged. Besides, overexpression of metadherin (MTDH) was attenuated in tumor tissues of TRP-fed mice. Taken together, these findings suggest that the TRP-induced apoptosis of tumor tissues is through a mitochondria-mediated intrinsic apoptotic pathway.

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21:08

Young Hive Bees Poisoned By Insecticides Gathered By Addled Forager Bees "IndyWatch Feed Health"

 

Young Hive Bees Poisoned By Insecticides Gathered By Addled Forager Bees

By Brandon TurbevilleNatural Blaze

New research in both Europe and the United States has demonstrated yet another disturbing link between insecticides known as neonicotinoids and their adverse effects on honey bees. Prior to the research, which was conducted at the University of Buenos Aires by Carolina Gonalons and Walter M. Farina, it was already widely known that chemicals like Glyphosate, the most widespread weedkiller in history, is at least partly responsible for the decline in the bee population.

The new research decided to examine the effects of field-realistic concentrations of common farm chemicals on young worker bees.

SEE: Two New Studies Confirm Common Insecticide Weakens Honeybee Hives

...

21:07

Digital Addiction Increases Loneliness, Anxiety and Depression "IndyWatch Feed Health"

Digital Addiction Increases Loneliness, Anxiety and Depression

By Natural Blaze

How to Outsmart Digital Isolation and Addiction, According to San Francisco State University

Smartphones are a permanent fixture in most peoples lives, a constant source of notification and quasi-connection. The downside of that convenience is that many of us are also addicted to the constant pings, chimes, vibrations and other alerts from our devices, unable to ignore new emails, texts and images. We are addicted to logging in.

In a new study published in NeuroRegulation, San Francisco State University Professor of Health Education Erik Peper and Associate Professor of Health Education Richard Harvey argue that overuse of smart phones is just like any other type of substance abuse.

The behavioral addiction of smartphone use begins forming neurological connections in the brain in ways similar to how opioid addiction is experienced by people taking Oxycontin for pain relief gradually, Peper explained.

On top of that, addiction to social media technology may actually have a negative effect on social connection. In a survey of 135 San Francisco State students, Peper and Harvey found that students who...

21:07

Illinois Wants to Use Taxpayer Funds to Advertise Dangerous Flu Shot to School Children "IndyWatch Feed Health"

Illinois-License-Plate-Vaccines

Comments by Brian Shilhavy
Editor, Health Impact News

Illinois legislators will take up a bill this week (April 17, 2018 at 3:00 PM) that uses taxpayer funds to advertise the dangerous flu shot to school children.

Given the fact that Illinois laws already require school children to visit their doctors before attending school where their family physician can educate them on matters like vaccination, and that the CDC does NOT include the flu shot in their schedule of required vaccines, this proposed bill in Illinois can only be explained as an attempt to expand the market for the seasonal flu shot at the expense of Illinois school children, but to the benefit of Big Pharma.

The annual flu shot is, by far, the most dangerous vaccine in the United States, accounting for more than 80% of all injuries and deaths compensated by the federal Vaccine Court.

OPPOSE SB 2654 and HB 4475 Schools Marketing Flu Vaccines

by the National Vaccine Information Center

Your swift action is needed this week to OPPOSE SB 2654 and HB4475 which require schools to inappropriately push flu vaccine promotional material on school families.

This is wrong. Schools should not be in the business of marketing vaccines. Children in Illinois are already required by state law to visit their doctors before attending school where doctors educate on diseases and vaccines during their exam. The flu vaccin...

20:36

Illinois Wants to Use Taxpayer Funds to Advertise Dangerous Flu Shot to School Children "IndyWatch Feed Health"

Illinois-License-Plate-Vaccines

Comments by Brian Shilhavy
Editor, Health Impact News

Illinois legislators will take up a bill this week (April 17, 2018 at 3:00 PM) that uses taxpayer funds to advertise the dangerous flu shot to school children.

Given the fact that Illinois laws already require school children to visit their doctors before attending school where their family physician can educate them on matters like vaccination, and that the CDC does NOT include the flu shot in their schedule of required vaccines, this proposed bill in Illinois can only be explained as an attempt to expand the market for the seasonal flu shot at the expense of Illinois school children, but to the benefit of Big Pharma.

The annual flu shot is, by far, the most dangerous vaccine in the United States, accounting for more than 80% of all injuries and deaths compensated by the federal Vaccine Court.

OPPOSE SB 2654 and HB 4475 Schools Marketing Flu Vaccines

by the National Vaccine Information Center

Your swift action is needed this week to OPPOSE SB 2654 and HB4475 which require schools to inappropriately push flu vaccine promotional material on school families.

This is wrong. Schools should not be in the business of marketing vaccines. Children in Illinois are already required by state law to visit their doctors before attending school where doctors educate on diseases and vaccines during their exam. The flu vaccine i...

19:57

A review of the research progress on anti-tumor effect of Huaier. "IndyWatch Feed Health"

PMID:  Zhongguo Zhong Yao Za Zhi. 2015 Dec ;40(24):4805-10. PMID: 27245026 Abstract Title:  [Research progress on anti-tumor effect of Huaier]. Abstract:  Huaier (Trametes robiniophila) has been widely used as an adjuvant drug for cancer treatment in China. The anti-cancer effect of Huaier extract has been confirmed in liver cancer, lung cancer, breast cancer, ovarian cancer, gastric cancer, and so on. The main mechanisms by which Huaier exerts an anti-neoplastic effect include inhibition of the growth and proliferation of cancer cells, induction of apoptosis of cancer cells, suppression of angiogenesis, inhibition of the invasion and migration of cancer cells, regulation of oncogenes and tumor suppressor genes expression, improving immunity, and reversal of drug resistance in cancer cells. In order to provide references for further study and clinical application on anti-tumor effect of Huaier, the latest research progress on anti-tumor effect of Huaier in recent years is summarized in this paper.

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19:34

Ten Awesome Gardening Hacks to Make Life Easier "IndyWatch Feed Health"

Source: Ten Awesome Gardening Hacks to Make Life Easier For more content like this visit REALfarmacy.com.

Tips and hacks for your garden! Sometimes its hard to get creative when you hit a rut or get discouraged. Its easy to make a problem worse and harder on yourself if you dont have some tested tricks to adapt to your issue. This video mentions some useful ideas you may have never thought of. []

Source: Ten Awesome Gardening Hacks to Make Life Easier Learn more at REALfarmacy.com - Healthy News and Information.

19:21

Huaier may be a promising therapeutic drug for tuberous sclerosis complex. "IndyWatch Feed Health"

PMID:  Oncol Rep. 2016 Sep ;36(3):1491-8. Epub 2016 Jul 25. PMID: 27461043 Abstract Title:  Huaier aqueous extract inhibits proliferation and metastasis of tuberous sclerosis complex cell models through downregulation of JAK2/STAT3 and MAPK signaling pathways. Abstract:  Tuberous sclerosis complex (TSC) is a genetic disorder with formation of benign tumors in many different organs. It has attracted increasing attention from researchers to search for therapeutic drugs for TSC patients. Traditional Chinese medicine (TCM) has become an important source for finding antitumor drugs. Trametes robiniophila urr. (Huaier) is a kind of officinal fungi in China and has been applied in TCM for approximately 1,600 years. A large number of clinical applications have revealed that Huaier has good antitumor effect. In this study, we have investigated the effects of Huaier aqueous extract ontwo TSC cell models, including inhibition of proliferation, induction of apoptosis, cell cycle arrest, and anti-metastasis. We demonstrated that Huaier aqueous extract inhibited JAK2/STAT3 and MAPK signaling pathways in a dose-dependent manner. Therefore, based on the low toxicity and the multi-targets of Huaier treatment, Huaier may be a promising therapeutic drug for TSC.

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18:30

Children prefer to read books on paper rather than screens "IndyWatch Feed Health"

Margaret Kristin Merga, Murdoch University and Saiyidi Mat Roni, Edith Cowan University

There is a common perception that children are more likely to read if it is on a device such as an iPad or Kindles. But new research shows that this is not necessarily the case.

In a study of children in Year 4 and 6, those who had regular access to devices with eReading capability (such as Kindles, iPads and mobile phones) did not tend to use their devices for reading and this was the case even when they were daily book readers.

Research also found that the more devices a child had access to, the less they read in general.

It suggests that providing children with eReading devices can actually inhibit their reading, and that paper books are often still preferred by young people.

These findings match previous research which looked at how teenagers prefer to read. This research found that while some students enjoyed reading books on devices, the majority of students with access to these technologies did not use them regularly for this purpose. Importantly, the most avid book readers did not frequently re...

18:26

A Survival Technique Everyone Should Know "IndyWatch Feed Health"

Source: A Survival Technique Everyone Should Know For more content like this visit REALfarmacy.com.

First of all please dont chew the brand of gum used in this demo (its loaded with aspartame, a known toxic sugar substitute). With that being said, this is one trick that is a need-to-know survival skill. Using common litter this way in a serious collapse-like scenario could save your life. Or maybe you can []

Source: A Survival Technique Everyone Should Know Learn more at REALfarmacy.com - Healthy News and Information.

17:38

Caught Our Notice: Forged email for corresponding author dooms diabetes paper "IndyWatch Feed Health"

Title: Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction What Caught Our Attention: PLOS ONE had a few reasons for retracting a 2015 paper about a treatment for kidney disease due to diabetes: For one, despite what the paper claims, the authors did not obtain ethical approval to conduct the reported Continue reading Caught Our Notice: Forged email for corresponding author dooms diabetes paper

15:42

Your Pharmacist is Tattling On You! "IndyWatch Feed Health"

A CVS pharmacy recently sent me a standardized form by fax with a dire warning about one of my patients. The elaborate document was titled CVS caremark. It came from Prescriber Services and provided Patient Information for Your Consideration. This link takes you to the document sent to me by a CVS located a number of miles outside Ithaca, New York. It constitutes an enormous and potentially harmful infringement on the privacy of CVS customers.

Pharmacists and Pharmacies Do Have Responsibility to Report Medical Errors

There are many good reasons for pharmacists to contact prescribers. Out of ignorance or carelessness, or simple human error, doctors make prescription errors. In my forensic work, I have seen ethical pharmacists inform doctors that their patients were being prescribed addictive benzodiazepines, such as Xanax and Ativan, in doses that were too high for too long a time. I have also been an expert in legal cases in which pharmacies have warned doctors about potentially dangerous drug interactions.

In one case, an infant was brain-damaged over several months while being prescribed a whopping overdose of a CNS drug. A new pharmacy warned the doctor that the dose was much too large, and it turned out the pediatrician had made a mathematical error when calculating it for the infant.

Overall, I am strongly in favor of pharmacists reporting to a prescriber when potential errors have been made by the prescriber.

CVS Was Not Reporting a Medical Error; It was Tattling

So what about this warning distressed me? The form was called MEDICATION NONADHERENCE THERAPY ADVISORY. CVS instructed me, A review of your patients retail and mail prescription history indicates that the patient has not obtained his or her first refill. Consider discussing your patients therapy to reinforce that nonadherence to his or her medication regiment could lead to a hospital or emergency room visit, or death.

Notice the assumption that a patients failure to utilize a renewable prescription for a psychiatric drug was a form of disobedience! Notice the presumption that it was necessary and ethical to report this to the prescriber.

The drug was quetiapine 25 mg. Quetiapine or Seroquel is an antipsychotic medication and a dose of 25 mg is the smallest available. So why did the pharmacy care? Because, they assumed, as their form states, that my patient was suffering from nonadherence, more commonly called noncompliance.

Noncompliance or nonadherence is a sin among psychiatric prescribers. Nonadherence costs the pharmaceutical in...

15:09

I Hope Trump is Still on Our Side "IndyWatch Feed Health"

By Kent Heckenlively, JD I admit this with the same passion I would admit to being an alcoholic or drug addict.  I have Q-Anon linked stress disorder. Are any of you suffering from this as well? If any of you are confused as to what Im speaking about, let me explain.  On some internet chat boards Continue reading I Hope Trump is Still on Our Side

The post I Hope Trump is Still on Our Side appeared first on BolenReport.

14:00

Whoops: Authors didnt mean to include new data in article about transgender identity "IndyWatch Feed Health"

Heres something we dont see that often authors retracting one of their articles because it included new data. But that is the case with a 2017 review exploring the potential genetic and hormonal underpinnings of gender identity.  The authors Rosa Fernndez Garca and Eduardo Psaro Mendez told Retraction Watch that they asked bioethics journal Continue reading Whoops: Authors didnt mean to include new data in article about transgender identity

12:02

The Silence: The Legacy of Childhood Trauma "IndyWatch Feed Health"

In this piece for The New Yorker, Junot Diaz reflects on the impact of his experience of childhood sexual abuse and the ways that therapy helped him heal.

That violacin. Not enough pages in the world to describe what it did to me. The whole planet could be my inkstand and it still wouldnt be enough. That shit cracked the planet of me in half, threw me completely out of orbit, into the lightless regions of space where life is not possible. I can say, truly, que casi me destruy. Not only the rapes but all the sequelae: the agony, the bitterness, the self-recrimination, the asco, the desperate need to keep it hidden and silent. It fucked up my childhood. It fucked up my adolescence. It fucked up my whole life. More than being Dominican, more than being an immigrant, more, even, than being of African descent, my rape defined me. I spent more energy running from it than I did living. I was confused about why I didnt fight, why I had an erection while I was being raped, what I did to deserve it. And always I was afraidafraid that the rape had ruined me; afraid that I would be found out; afraid afraid afraid. Real Dominican men, after all, arent raped. And if I wasnt a real Dominican man I wasnt anything. The rape excluded me from manhood, from love, from everything.

12:01

How Compassion Can Triumph Over Toxic Childhood Trauma "IndyWatch Feed Health"

From Medical Xpress: New research findings suggest that when pregnant women who have experienced adverse childhood experiences (ACEs) feel supported by those around them, their risk of having pregnancy complications is significantly decreased.

Article 

11:58

The deaths of healthy children taken for routine immunisation are not acceptable. "IndyWatch Feed Health"

by Jacob Puliyel On 18 March, The Sunday Guardian [India] published a report suggesting that Pentavalent vaccine was killing children instead of protecting them. In response to a question on the subject, Union Minister for Health and Family Welfare Ashwini...

11:47

This New Treatment Could Heal Tooth Cavities Without Any Fillings "IndyWatch Feed Health"

It regrows the enamel itself.

Scientists have invented a new product that can encourage tooth enamel to grow back, which means we could finally have a game-changing way to treat dental cavities.

Researchers at the University of Washington have developed a treatment based on peptides short chains of amino acids, linked by peptide bonds, that arent long enough to be considered full proteins.

When applied to artificially created dental lesions in a laboratory setting, the product remineralised tooth enamel, effectively healing the lesion.

Remineralisation guided by peptides is a healthy alternative to current dental health care, said materials scientist Mehmet Sarikaya.

Tooth enamel is produced by a type of cell called an ameloblast. These secrete the proteins that form enamel while the tooth is still in the gum.

Unfortunately, once the process of forming tooth enamel is complete and the tooth has emerged, our ameloblasts die off. But we continue to lose enamel throughout our lifetime.

Bacteria metabolise sugar and other fermentable carbohydrates in oral environments and acid, as a by-product, will demineralise the dental enamel, said dentistry researcher Sami Dogan.

To a small extent, our teeth can be remineralised with the help of saliva, fluoride toothpaste and drinking water additives.

But once theres a visible cavity on the tooth, it needs to be treated by a dentist which usually means drilling, and packing the hole with a dental filling.

To develop their new treatment, the team turned to one of the proteins produced by ameloblasts. Called amelogenins, these proteins play a key role in regulating the formation of tooth enamel.

The team designed peptides based on this protein and created a treatment with the peptide as an active ingredient.

They applied it to dental lesions in a laboratory setting and found that it helped form a new mineralised layer to the demineralised areas, integrating it with the enamel underneath.

...

11:00

If Age of Autism is a Bit Hinky Today, Have No Fear "IndyWatch Feed Health"

Our blogging platform will be undergoing some maintanance today, so if things are wonky, it is not because Zuckerburg, Gates or the CDC is messing with us.

07:00

Can Sumac Help Your Blood Sugar Levels? "IndyWatch Feed Health"

By Dr. Mercola

If you enjoy Middle Eastern and Mediterranean cuisine, youve likely eaten sumac, perhaps without knowing it. Im not talking about the wild plant that causes contact dermatitis in the majority of people who touch it. No, the sumac I have in mind is a tart, edible powder used in dry rubs, marinades, salad dressings and spice blends. It gives a pop of deep red color and a lemony tang to chicken, fish, lamb and vegetable dishes.

Most notably, sumac is featured prominently in the spice mix zaatar and also is commonly found on fattoush salad and hummus.1 When ground, sumac powder can be mistaken for paprika, but its tangy punch is distinctive. If you are wondering why you should care about sumac, you may be interested to know this intriguing spice has been called out for its positive effects on your blood sugar levels, in addition to a number of other health benefits.

What Is Sumac?

Not to be confused with poison sumac, which can give you an itchy rash upon contact, the sumac varieties Im discussing hail from the red berries produced by the sumac bush. While it is native to the Middle East, sumac has spread far and wide to other regions. When ground into a coarse powder, sumac adds a colorful, slightly sour, lemony tang to a variety of dishes.

About sumac, The Kitchn says, Sumac is a widely used, essential spice in Middle Eastern and Mediterranean cooking. It's used in everything from dry rubs to marinades and dressing. But its best use is sprinkled over food before serving. Given its increasing popularity, you may be able to find it among other herbs and spices in your local grocery store.

You can easily distinguish edible and poisonous sumac by looking at the berries. The berries of poison sumac varieties are white or gray in color and droop from the branch. In contrast, the edible berries of staghorn sumacs and other nonpoisonous varieties are a deep red color and attached to upright stalks.2 Some varieties of sumac are considered to be an invasive species in parts of the U.S. and have proven difficult to eradicate.3

Sumac Is Rooted in History

American Forest shares these interesting facts about sumac:...

Best Vegetables for Your Heart "IndyWatch Feed Health"

By Dr. Mercola

Research has shown that the more vegetables you eat, the lower your risk of heart disease, with different types of vegetables protecting your heart through different mechanisms. Leafy greens, for example, have high amounts of nitrates that naturally boost your nitric oxide (NO) level.1 Cruciferous veggies, on the other hand, lower your risk of stroke and heart attack by promoting more supple neck arteries and preventing the buildup of arterial plaque.

In fermented cabbage, it's the fiber content that helps lower blood pressure and improve blood sugar control, thereby lowering your risk of heart problems. Phytonutrients in sauerkraut also help promote easy blood flow and flexible blood vessels, and veggies rich in magnesium and quercetin also provide important heart benefits. Following is a summary of some of the top vegetable types for maintaining healthy heart function well into old age.

Nitrate-Rich Veggies Boost Heart Health and Lower Risk of Heart Attack

NO is an important biological signaling molecule that supports normal endothelial function and protects your mitochondria. A potent vasodilator, it also helps relax and widen your blood vessels, which improves blood flow. A recent study published in The American Journal of Clinical Nutrition,2 which followed nearly 1,230 seniors for 15 years, found that the higher an individual's vegetable nitrate intake, the lower their risk for atherosclerotic vascular disease (ASVD) and all-cause mortality.

According to the authors, "These results support the concept that nitrate-rich vegetables may reduce the risk of age-related ASVD mortality." Research3 has also shown a diet high in vegetable nitrates helps prevent and treat prehypertension and hypertension (high blood pressure), and protects against heart attacks, courtesy of their NO-boosting power.

Vegetable nitrates should not be confused with the nitrates found in processed meats such as bacon, hot dogs, ham and other cured meats. Dietary nitrates can convert into either NO or nitrosamines, the latter of which are carcinogenic and should be avoided as much as possible....

Weekly Health Quiz: Herbs, Vegetables and Obesity "IndyWatch Feed Health"

1 Adaptogenic herbs such as ashwagandha, tulsi, rhodiola and ginseng protect and improve your health by helping your body adapt to:

  • Stress, regardless of the source

    Adaptogens are unique in that they help your body adapt to stress, in part by regulating hormones and improving your immune function. Learn more.

  • Climactic changes (changes in temperature)
  • Assaults by never-before-encountered microbes
  • Potential allergens, including seasonal allergens

2 Three recent studies two by the U.S. National Toxicology Program and one by the Italian Ramazzini Institute has linked cellphone radiation to:

  • Radically increase the risk of neurodegenerative diseases like Alzheimer's
  • Cause an increase in insulin resistance and diabetes
  • DNA damage and an increased risk of rare heart and brain tumors

    Three studies published in the first quarter of 2018 have produced evidence linking cellphone radiation to DNA damage, low body weight and rare tumors in the heart, brain and other organs. Learn more.

  • DNA damage and an increased risk for obesity

3 Which of the following has been shown to be a significant contributor to obesity?

  • Processed foods and fast food
  • Artificially-sweetened foods and beverages
  • Low-fat foo...

The Benefits of Baobab "IndyWatch Feed Health"

By Dr. Mercola

If you should visit the markets across the African continent, youd find an interesting looking fruit harvested from the baobab tree (pronounced bay-oh-bahb, emphasizing the first syllable) has earned not just popularity in its native regions but superfood status worldwide. A member of the silk-cotton family (Adansonia digitata), the baobab tree typically reaches as high as 90 feet and 60 feet wide, with a broad trunk.

Merriam-Webster dictionary1 notes that its native to Africa and bears an edible, acidic, hanging fruit resembling a gourd and weighing about 3 pounds. Madagascar, the Middle East and Australia have trees related to the baobab, and theyre all incredibly resilient and long-lived, surviving up to 500 years. The bark has been (and still is) used to make cloth, rope, clothing and paper, but every part of the baobab tree has been utilized. The fruit has also been used as a natural preservative, according to Medical News Today.2

This is the only fruit in the world that dries naturally on the branch after baking in the sun for six months. Then, the large, brittle, teardrop-shaped baobab fruits (or shells) are wild-harvested in a process that involves splitting them open with a hammer or large knife to reveal a dry, cream-colored pulp surrounded by (but separated from) the seeds, which sound like a rattle when theyre ready for harvest. Pounding the pulp into a fine powder using pestles and mortars is the final step of a rather labor-intensive process.

According to The Guardian, baobab fruit contains high levels ofantioxidants, potassium and phosphorus, along with high levels of vitamin C, calcium and fiber.3 Besides commodity marketing in areas of gin and beauty products, baobab fruit, described as having a sherbet-like taste, has been diversified to make baobab yogurt, salads, smoothies, cereals, granola bars and butter, the latter being used for things like pan-frying wild-caught Alaskan salmon and flavoring baobab popcorn.

However, for manufacturing purposes, the powdered pulp is often packaged and transported to grocery stores and outlets all over the world. Some are sterilized and otherwise processed, but you may be able to find the raw, natural powder in some supermarkets.

Health Benefits of Baobab Powder

As the source of traditional medicine, the leaves an...

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Sunday, 15 April

22:23

Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis. "IndyWatch Feed Health"

PMID:  Oncotarget. 2017 May 16 ;8(20):32937-32945. PMID: 28380426 Abstract Title:  Huaier aqueous extract protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NLRP3 inflammasome activation. Abstract:  The use of Trametes robiniophila Murr. (Huaier) as a complementary therapy for cancer has recently become increasingly common in China. However, whether Huaier can regulate host immune responses, especially innate immunity, remains largely unknown. The NLRP3 inflammasome is a multimeric complex consisting of NLRP3, ASC and caspase-1. NLRP3 inflammasomes respond to a variety of endogenous (damage-associated molecular patterns) and exogenous (pathogen-associated molecular patterns) stimuli, and play crucial roles in host defense against pathogens and multiple diseases such as ulcerative colitis (UC). In this study, we investigated the anti-inflammatory effect of Huaier in dextran sulfate sodium (DSS)-induced murine colitis and revealed the underlying mechanisms by targeting NLRP3 inflammasomes. In C57BL/6 mice, oral administration of Huaier attenuated DSS-induced colon shortening and colonic pathological damage. Furthermore, we analyzed the effect of Huaier on NLRP3 inflammasome activation in macrophages. Huaier inhibited NLRP3 inflammasome activation-induced IL-1 secretion and caspase-1 cleavage. Moreover, Huaier decreased NLRP3 protein expression via promoting NLRP3 degradation through the autophagy lysosome pathway. Therefore, our findings demonstrate a novel function for Huaier in the regulation of NLRP3 inflammasome activation and suggest a potentialrole for Huaier in NLRP3 inflammasome-associated diseases.

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Friday, 13 April

12:15

Oamaru: Children needed for fluoride study "IndyWatch Feed Health"

University of Otago researchers want help from Oamaru children.

The university is embarking on a major fluoride study in the town.

Dr Sheila Skeaff said the focus of the study, taking place during the school holidays, was to monitor fluoride consumption among children between the ages of 9 and 11.

The study would ask parents and children to keep a diet diary each day for two weeks of the food and drink the children consumed.

Children were also required to brush their teeth in front of the project group.

We get them to spit in a container so we can collect that and we can work out how much toothpaste they had and know how much fluoride was in the toothpaste, Dr Skeaff said.

It had been difficult finding volunteers for the study, Dr Skeaff said.

At the moment, weve only got five kids, and we could probably grab another 30 to 40.

We really only want five to 10 kids per school, she said.

Two masters students from the project had travelled to Oamaru schools on separate occasions to recruit children.

Even though some of the kids seem keen, were not getting the consent forms back, she said.

The university would try recruiting children through school holiday programmes.

Similar studies had been conducted in the 1990s, Dr Skeaff said.

Children would also have to provide urine samples for testing.

Parents who want their children to take part in the study can contact Dr Skeaff by email (floss.2018@otago.ac.nz) or phone (022 465-4753).

Children who participate in the study will be given movie passes to Limelight Cinema.

*Original article online at http://www.oamarumail.co.nz/uncategorized/children-needed-for-fluoride-study/

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