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Thursday, 19 April

18:01

Egg Recall: 200M Eggs Recalled Over Fears of Salmonella Braenderup "IndyWatch Feed Health"

In the United States largest egg recall since 2010, a possible salmonella contamination has led Seymours Indianas Rose Acre Farms to voluntarily recall over 200 million eggs! In fact, the actual number of recalled eggs is 206,749,248 and, to make matters more worrisome, theyve all been distributed, sold, and consumed under multiple brand names, including:[1]... View Article

The post Egg Recall: 200M Eggs Recalled Over Fears of Salmonella Braenderup appeared first on Healthy Holistic Living.

17:08

Political science has a #metoo moment "IndyWatch Feed Health"

Many political scientists are up in arms over an editors decision to use his journal as a platform to defend himself from allegations of sexual harassment. The editor, William Jacoby of Michigan State University, has since removed a statement denying the allegations from the American Journal of Political Science (AJPS), and posted an apology. Midwest Continue reading Political science has a #metoo moment

16:36

Recent Local Victories and a Bumper Weekend Ahead "IndyWatch Feed Health"

Before we get to the local victories, here is an update on our Fundraiser.

A bumper weekend ahead

Yesterday, thanks to supporters like you, we reached a magnificent $51,662 from 370 supporters in our Fundraiser for our TSCA lawsuit*, which included a pledge of $250 for reaching 350 donors. But there are several more pledges ahead and it promises to be a bumper weekend if the donations keep rolling in.

30 more donors of any amount will trigger a pledge of $500.

60 more donors of $10 or more will trigger a pledge of $5,000.

80 more donors of any amount will trigger a pledge of $750.

97 more donors via mailed-in check of $5 or more will trigger another $5000.

130 more donors of any amount will trigger a pledge of $1500.

You can be part of our FAN team and help our total leap forward with a donation of $5 by mailed in check or $10 or more via online.

You can follow the excitement online by checking the first masthead on our web page www.FluorideALERT.org

How to donate

  • Online at our secure server.
  • Or by Check, payable to the Fluoride Action Network. Send your check to:
    Fluoride Action Network
    c/o Connett
    104 Walnut Street
    Binghamton NY 13905

The first local victory came in Edgartown, Massachusetts.  On April 12, a referendum vote of 700-253 (a whopping 73%-23%), ended all hope of fluoridation in Edgartown. According to a report on the in The Marthas Vineyard Times,

The towns board of health...

16:27

Latest brain images from sleep study stun experts "IndyWatch Feed Health"

By Dr. Mercola According to the American Sleep Association, up to 70 million Americans have a sleep disorder, nearly 40 percent unintentionally fall asleep during the day at least once a month and nearly 5 percent have nodded off while driving at least once. Insomnia is the most common sleep disorder, with 10 percent of American

15:28

Jaipur will install 200 free RO water kiosks across the city "IndyWatch Feed Health"

Jaipur Municipal Corporation (JMC) is all set to restart the age-old tradition of setting up Piyau (Water Hut) in Pink City, however in a different manner.

The municipal corporation will be introducing the concept of modern Piyau. Under this plan, drinking water kiosks will be installed at 200 locations across the city by JMC.

People will get RO [reverse osmosis] water on these kiosks, without paying for it. The municipal corporation has issued orders for kiosks. Installation of these kiosks will begin next week. For these water kiosks, the municipal corporation has signed a contract with an NGO Ekajal Sanstha. JMC will set up these water kiosks on public-private partnership (PPP)basis. The Ekajal Sanstha will not take any amount from the municipal corporation for the installation of kiosks and water.Instead, the Municipal Corporation will provide space to the organisation for kiosks by marking the location.

Additionally, the institution will be able to advertise on 50 square feet area around the kiosks. Company can cover water kiosk expenditure through advertising. According to municipal authorities,the institution will install RO machines of modern technology on kiosks.The cost of this machine will be around 18 lakh rupees.The water machine on each kiosk will discharge 1,000 litres of water in one hour. This machine will also clean the elements from water like arsenic, lead and fluoride.

We have issued the LOI (Letter of Interest) to the institution for water kiosks. Soon the institution will start installing the kiosks. The public will get pure RO water on kiosks and they will not have to pay for this.It will be for the first time in the city that local people will get purer water than the bottle packed water, said mayor Ashok Lahoti.

Water Kiosks

  • Under the plan, drinking water kiosks will be installed at 200 locations across the city by JMC.
  • People will get RO water on these kiosks, without paying for it. The municipal corporation has issued orders for the kiosks.
  • For these water kiosks, JMC has signed a contract with an NGO Ekajal Sanstha. The institution will install RO machines of modern technology on kiosks.The cost of this machine will be around 18 lakh rupees.The water machine on each kiosk will discharge 1,000 litres of water in one hour. This machine will also clean the elements from water like arsenic, lead and fluoride.

*Original article titled Jaipur Municipal Corporation all set to restart Piyaus for parched city online at http://www.dnaindia.com/jaipur/r...

15:19

Adding fluoride to Meadvilles water awaits DEP permit issuance "IndyWatch Feed Health"

VERNON TOWNSHIP Meadville Area Water Authority has taken another step in the bureaucratic process required to follow through on its June 2017 decision to add fluoride to its water supply.

The authority addressed comments it received from the state Department of Environmental Protection on its fluoride permit application, Gannett Fleming consulting engineer Thomas Thompson told board members at Wednesdays authority meeting.

Were still waiting for the DEP permit to be issued, Thompson said. Once the permit is issued, he explained after the meeting, the authority can solicit bids for installation of the fluoridation equipment. The bid process and installation will likely take six to eight months, he said.

DEP received MAWAs permit application Oct. 30, according to Melanie Williams, community relations coordinator at the department.

It was published in the Pennsylvania Bulletin on Nov. 18, 2017, which formally began the 30-day public comment period, Williams said in an email. The department did not receive any comments from the public during that 30-day period from Nov. 18, 2017, until Dec. 18, 2017.

DEP decisions on such applications typically take 120 business days or about seven months, according to Williams.

The comments received from DEP concerned a section of the report addressing the impact of introducing fluoride into the system as well as clarifications on some of the construction design drawings.

They wanted that emphasized a little more in the report, Thompson said, explaining that the revised response highlighted the impact of fluoride on the system. It doesnt have an effect on the water quality and thats what the information had previously presented.

*Original article online at http://www.meadvilletribune.com/news/local_news/adding-fluoride-to-meadville-s-water-awaits-dep-permit-issuance/article_bc3aedf4-9980-5908-b0d2-c2cde9f51102.htmlNext

15:17

Oberon will have to wait longer for a fluoride decision "IndyWatch Feed Health"

OBERON Council will wait until June or July to make a decision on whether to reverse its official long-standing opposition to fluoride in the town water supply.

A recommendation was tabled at Oberon Councils ordinary meeting on Tuesday night that council provide some direction in relation to the review of the fluoridation policy, but a final decision still remains unclear.

Cr Brenda Lyon moved a motion on Tuesday night not to review councils standing resolution not to fluoridate Oberons public water supply, but the motion was lost.

Mayor Kathy Sajowitz moved an amended motion, which was carried, that council undertake a review through the upcoming Community Engagement Strategy public meetings  of councils policy on fluoride and for the issue to be tabled at the June or July council meeting for a decision.

After substantial community consultation and public meetings held in Oberon in 2013, council resolved not to support the addition of fluoride in the Oberon water supply, but it was a heated debate at the time.

After receiving correspondence from the Oberon Health Council and the Minister for Health and Minister for Medical Research in December 2017, council resolved to accept the offer of a face-to-face briefing for council and senior staff, led by qualified people from NSW Health, on the evidence supporting fluoridation.

Further, council agreed that qualified people among the opponents to fluoridation brief council and senior staff on the evidence against the fluoridation of Oberons water supply.

These meetings were held in March.

Councils Community Engagement Strategy draft plan, which had been on public exhibition since councils March meeting, was adopted on Tuesday night without changes.

Public meetings to inform the community about the draft plan will be held in May and council will take the opportunity at these meetings to hear from the community about fluoridation.

The meetings will be:

  • Monday, May 21  Robert Hooper Community Centre, Oberon, 6pm.
  • Wednesday, May 23  OConnell Fire Shed, 1891 Mutton Falls Road, O...

14:00

Research problems at Australian university hit the news "IndyWatch Feed Health"

A university in Australia thats made headlines before over allegations of research misconduct has found itself in the news once again. Last week, the University of Queensland (UQ) announced some of its authors were retracting a paper after discovering data were missing. Just days later, the university made headlines over an investigation into three papers Continue reading Research problems at Australian university hit the news

12:02

Call for Submissions: Smash Paternalism Anthology "IndyWatch Feed Health"

A new anthology is seeking essays, short stories, poetry, and visual art on the topic of paternalism, i.e. abuses or human rights violations that are said to happen for ones own good. Click here to find out more about the anthology and how to submit your work.

12:01

A Mental Health Crisis is the True Cost of University Marketization "IndyWatch Feed Health"

From Red Pepper: University students are facing unprecedented rates of mental health crises due to a combination of financial insecurity and ever-increasing academic pressure.

Meanwhile, our futures promise astronomical debt levels and so, theres more pressure than ever to make that gamble count for something, securing the graduate premium on future earnings. In reality, that premium is shrinking; the earnings gap between those with degrees and those without them will shrink further  partly due to more people going to university, but corollary to an enormous drop in wages and a rise in deskilled, precarious employment across the board. Rewarding jobs are fewer and further between, and many students are left with those tens of thousands of pounds of debt and wages too low to compensate for them. This fosters an even more ruthlessly competitive environment. This undermines meaningful education in favour of metrics designed to evaluate transferable skills. But this cocktail of financial insecurity and a relentlessly high-pressure environment comes at a higher price still. The number of students reporting mental health issues has hit record levels, and so have the number of registrations to on campus counselling services. Suicide rates have soared to disturbing and unprecedented levels.

Article 

12:00

Philosophers Question the Separation of Medicine and Culture "IndyWatch Feed Health"

Dr. Julia Kristeva is a philosopher, literary critic, psychoanalyst, feminist, and novelist. She is professor emeritus at the University Paris Diderot.

07:00

The Many Benefits of Sage, the 'Savior' Herb "IndyWatch Feed Health"

A member of the mint family, sage (Salvia officinalis) originated from the northern Mediterranean coast, where it was traditionally used for cooking. Italians are known to add flavor to veal with sage, while the French use it for sausages, stuffing and cured meats. The herbs warm and musky essence also probably reminds you of homemade turkey dressing a Thanksgiving staple loved by many Americans.1

However, sage isnt just for cooking. In medieval times, it was called Salvia Salvatrix, which means sage, the savior. This is because it was one of the primary ingredients of the Four Thieves Vinegar, a concoction that was used by thieves to ward off the bubonic plague while plundering for treasures.2 Today, sage is known for its high antioxidant capacity and many health benefits.3 Learn about how you can use sage to take your health to new heights. 

What Makes Sage Healthy?

Sage has an extensive history as a medicinal herb. It was used by the ancient Egyptians to improve fertility, and in the first century CE, Dioscorides, a Greek physician, pharmacologist and botanist (now known as the father of pharmacology4), reported that sage can help stop wounds from bleeding, help disinfect sores and promote healing of ulcers. He also used sage juice to treat coughs and hoarseness.5

Since then, herbalists have used sage for treating different conditions, such as swelling, sprains, asthma and excessive menstrual bleeding.6

The health benefits of sage are attributed to flavonoids, such as apigenin, luteolin and diosmetin,7 which are known for their antioxidant and anti-inflammatory properties.8 Sage can also provide your body with rosmarinic acid, a polyphenolic compound with unlimited health potential. Due to the popularity...

Why Seasonal Allergies Cause 'Brain Fog' Here's What the Science Says "IndyWatch Feed Health"

By Dr. Mercola

Allergic rhinitis, or seasonal allergies, often referred to as hay fever, affect 20 million U.S. adults and more than 6 million children.1 The most common symptoms include sneezing, stuffy or runny nose, watery and itchy eyes and itching in your nose, mouth or throat, but a sizable number of allergy sufferers also experience noticeable brain fog as well.

What causes the fuzzy-headed feeling is up for debate, but many theories are out there. One of the simplest is that allergy symptoms can make it difficult to get a good nights sleep, which in turn makes you fatigued and takes a toll on your ability to think clearly and be productive. Others, however, believe there may be more to it than that, and the inflammation triggered by allergies may be directly or indirectly affecting the brain.

How do Allergies Affect Your Brain?

Allergies are your body's reaction to particles that it considers foreign (allergens). The first time your body encounters an allergen, your plasma cells release immunoglobulin E (IgE), an antibody specific to that allergen. IgE attaches to the surface of your mast cells, which are found in great numbers in your surface tissues, such as your skin and nasal mucous membranes, where they help mediate inflammatory responses. Mast cells release a number of important chemical mediators, one of which is histamine.

The second time your body encounters a particular allergen, within a few minutes your mast cells become activated and release a powerful cocktail of histamine, leukotrienes and prostaglandins, which trigger the entire cascade of symptoms you associate with allergies. As part of the immune response, proteins called cytokines are also released, all of which add up to serious inflammation in your body.

This inflammation, in turn, could affect your brain in a number of ways, from interfering with sleep, as mentioned, to affecting your ears. If your middle ear is unable to drain properly due to inflammation, for instance, it could cause feelings of brain fog or dizziness.2 Yet, research also suggests that allergies have a very real effect on cognitive function:

  • Allergies may impede learning in school-age children, and uncontrolled allergy symptoms can diminish cognitive function and learning3
  • People with seasonal allergies have disturbed co...

Many Insomniacs Remain Conscious During Sleep, Which Makes Them Think Theyve Not Slept a Wink "IndyWatch Feed Health"

By Dr. Mercola

According to the American Sleep Association,1 up to 70 million Americans have a sleep disorder, nearly 40 percent unintentionally fall asleep during the day at least once a month and nearly 5 percent have nodded off while driving at least once. Insomnia is the most common sleep disorder, with 10 percent of American adults struggling with chronic insomnia and 30 percent reporting occasional or short-term insomnia.

Interestingly, insomniacs will often insist theyve not slept a wink all night, even though theyve actually been sleeping. Researchers have now discovered theres a reason for this discrepancy in experience, and it has to do with consciousness. In a nutshell, even though the brain is sleeping, insomniacs remain consciously aware, and therefore believe theyve not slept at all.

Many Insomniacs Remain Conscious Even When Asleep, Study Finds

Daniel Kay, a psychology professor at Brigham Young University in Utah who led the study,2 told Medical News Today,3 [Y]ou can be consciously aware and your brain [can] be in a sleep pattern. The question is: What role does conscious awareness have in our definition of sleep?" Traditionally, its been believed that sleeping involves the absence of conscious awareness, but Kays team was able to conclude that this is not categorically true.

To investigate the role of consciousness during sleep, the team analyzed the sleep patterns and subjective experience of 32 people with insomnia and 30 who reported sleeping well.

Once the participants were deemed to be asleep, based on their brain patterns, a radioactive tracer was injected into their arms. Using brain imaging, the researchers were able to examine neurons that remained active during sleep, and their exact locations. The following morning, the participants were asked about their subjective experience of their sleep. Medical News Today explains the results:

The study found that people with insomnia who reported that they had been awake, even when the polysomnography showed otherwise, had increased activity in brain areas associated with conscious awareness during the dreamless phase of sleep that is, nonrapid eye movement sleep

[I]t is normal during the process of falling asleep for the brain to send inhibitory neurons that make people less and less consciously aware until they'...

02:51

Ozymandias: Population Meltdown in Scotland as Additional Support Needs Rise by 600% in a Decade "IndyWatch Feed Health"

by John Stone I have been looking at Scotlands 2017 special educational needs data, published last month amid zero publicity these days we do not even have to bury the bad news. It just gets published on a government...

01:16

Purple carrot extract was able to protect oral lesions induced by 4-nitroquinoline 1-oxide. "IndyWatch Feed Health"

PMID:  Med Oncol. 2018 Mar 15 ;35(4):54. Epub 2018 Mar 15. PMID: 29546679 Abstract Title:  Protective effects of purple carrot extract (Daucus carota) against rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Abstract:  The aim of this study was to evaluate the chemopreventive potential of purple carrot extract following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide (4NQO). For this purpose, histopathological analysis, proliferative status, antioxidant activity and inflammatory status were investigated in this setting. A total of 20 male rats were distributed into four groups as follows (n=5 per group): Group 1-free access to water and commercial diet for 12 weeks; Group 2-received 4NQO at 50 ppm dose in drinking water daily and commercial diet for 12 weeks; Group 3-free access to water and received diet supplemented with purple carrot extract (0.1 g/kg) for 12 weeks; andGroup 4-received 4NQO at 50 ppm dose in drinking water daily and diet supplemented with purple carrot extract (0.1 g/kg) for 12 weeks. Histopathological analysis revealed that animals treated with purple carrot extract reduced the oral lesions such as dysplasia and squamous cell carcinoma. Animals with oral pre-neoplastic lesions and treated with purple carrot extract decreased ki-67 and 8-OHdG immunoexpression. Moreover, pNFBp50 and MyD88 protein expressions were decreased after purple carrot treatment associated or not with 4NQO exposure. SOD-Mn mRNA levels increased with treatment withpurple carrot extract as well. In conclusion, our results demonstrated that purple carrot extract was able to protect oral lesions induced by 4NQO in Wistar rats as a result of antioxidant activity, anti-inflammatory potential and antiproliferative and antimutagenic actions.

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01:13

Purple carrot can attenuate the inflammatory reaction in mice with dextran sulfate sodium-induced colitis. "IndyWatch Feed Health"

PMID:  Prev Nutr Food Sci. 2018 Mar ;23(1):77-83. Epub 2018 Mar 31. PMID: 29662851 Abstract Title:  Anti-Colitic Effect of Purple Carrot on Dextran Sulfate Sodium (DSS)-Induced Colitis in C57BL/6J Mice. Abstract:  The anti-colitic effect of purple carrot (PC) on 2% dextran sulfate sodium (DSS)-induced colitis in C57BL6/J mice was compared with those of yellow carrot (YC), beet (BT), and red cabbage (RC). Component analysis showed that PC contained cyanidin-3-xyloglucoside, cyanidin-3-xylosyl(sinapoly-glucosyl)galactoside, cyanidin-3-xylosyl(feruloylglucosyl) galactoside, and cyanidin-3--(6--glycosyl-2--xylosylgalactoside). PC diet (5% in AIN 93G diet) strongly reduced DSS-induced colon shortening and inflammatory cell infiltration in mice, followed by RC, BT, and YC diets. Treatment with PC reduced serum levels of pro-inflammatory cytokines such as tumor necrosis factor- and interleukin-6 as well as reduced mRNA expression in colon tissue of colitis mice in comparison with other treatments. In addition, PC treatment inhibited colonic mRNA expression of inflammatory factors such as inducible nitric oxide synthase and cyclooxygenase-2 in mice. These results suggestthat PC can attenuate the inflammatory reaction in mice with DSS-induced colitis, probably due to the anthocyanins in PC.

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01:03

Black adzuki bean extract protects pancreatic beta cells and improves glucose tolerance. "IndyWatch Feed Health"

PMID:  J Med Food. 2016 May ;19(5):442-9. Epub 2016 Apr 12. PMID: 27070495 Abstract Title:  Black Adzuki Bean (Vigna angularis) Extract Protects Pancreatic Cells and Improves Glucose Tolerance in C57BL/6J Mice Fed a High-Fat Diet. Abstract:  Adzuki beans have long been cultivated as a food and folk medicine in East Asia. In this study, we investigated the effect of black adzuki bean (BAB) extract on pancreatic cells and determined their mechanism of action in impaired glucose tolerance in an animal model of type 2 diabetes. In addition, we performed functional gene annotation analysis to identify genes related to the regulation of glucose metabolism and insulin response. Treatment of pancreatic cells with BAB extract (0.2mg/mL) led to tolerance of the high glucose-induced glucotoxicity, resulting in a similar viability as cells maintained in normal glucose media. In addition, dietary supplementation with BAB extract significantly (P

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00:59

Comparison of -amylase, -glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes. "IndyWatch Feed Health"

PMID:  Food Chem. 2017 Jan 1 ;214:259-268. Epub 2016 Jul 1. PMID: 27507474 Abstract Title:  Comparison of-amylase, -glucosidase and lipase inhibitory activity of the phenolic substances in two black legumes of different genera. Abstract:  Antioxidant-rich plant foods can inhibit starch and lipid digestions that are relevant to diabetes management. Two high-antioxidant black legumes, black soybean (Glycine max) and black turtle bean (Phaseolus vulgaris), belonging to two different genera were used to investigate their capacity against digestive enzymes. Phenolic substances were compared in crude, semi-purified extracts (semi-purified by XAD-7 column), and fractions (fractionationed by Sephadex LH-20 column) from these two legumes. In addition, their antioxidant capacities and abilities to inhibit digestive enzymes were characterized. Results showed that Fraction V from black soybean was the most effective (IC50: 0.25mg/mL) against-amylase; Fraction V from black turtle bean was the most potent (IC50: 0.25g/mL) against -glucosidase; Fraction IV from black turtle bean was the most powerful (IC50: 76g/mL) against lipase. Of the pure phenolic compounds tested, myricetin showed the highest inhibition of -amylase, -glucosidase and lipase (IC50: 0.38mg/mL, 0.87g/mL and 15g/mL, respectively).

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00:45

Peptides from common bean have antidiabetic and antihypertensive potential. "IndyWatch Feed Health"

PMID:  J Sci Food Agric. 2017 Jun ;97(8):2401-2410. Epub 2016 Oct 29. PMID: 27664971 Abstract Title:  Characterization of peptides from common bean protein isolates and their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress. Abstract:  BACKGROUND: Diabetes and hypertension are diseases affecting a high proportion of the world population; the use of food-based products such as common bean peptides may contribute to reduce the risk of complications associated to chronic diseases. The aim was to produce and characterize peptides from common bean protein isolates and evaluate their potential to inhibit markers of type-2 diabetes, hypertension and oxidative stress.RESULTS: Mexican black and Brazilian Carioca bean isolated proteins were characterized after pepsin/pancreatin digestion. Also, four synthesized pure peptides, originally found in these beans, were evaluated. Bean protein digests and pure peptides exerted dipeptidyl peptidase-IV (DPP-IV) inhibition (IC= 0.03-0.87 mg dry weight (DW) mL). Lineweaver-Burk plots and computational modeling showed competitive inhibition of DPP-IV. Angiotensin-converting enzyme (ACE) inhibition ranged from IC= 0.09 to 0.99 mg DW mL, and-glucosidase inhibition ranged from 36.3 to 50.1% mgDW. Carioca Perola bean digested proteins presented the highest antioxidant capacity (269.3 mmol LTrolox equivalent gDW) as the peptide KTYGL (P>0.05) with the most potent DPP-IV and ACE inhibition.CONCLUSION: Peptides from common bean have antidiabetic and antihypertensive potential regardless of their antioxidant capacity. 2016 Society of Chemical Industry.

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00:40

Black Adzuki bean attenuates high-fat diet-induced colon inflammation. "IndyWatch Feed Health"

PMID:  J Med Food. 2017 Apr ;20(4):367-375. PMID: 28406732 Abstract Title:  Black Adzuki Bean (Vigna angularis) Attenuates High-Fat Diet-Induced Colon Inflammation in Mice. Abstract:  Adzuki beans (Vigna angularis), one of the most important legume crops in East Asia, have been shown to possess potential antioxidant and anti-inflammatory effects in mice. Here, we investigated the effects of black adzuki bean (BAB) on colon inflammation triggered by high-fat diet (HD)-induced obesity in mice. We also isolated lipopolysaccharide (LPS)-stimulated peritoneal macrophages and assessed inflammation-related parameters. We found that BAB decreased the concentrations of LPS and various circulating proinflammatory cytokines such as tumor necrosis factor (TNF)-, interleukin (IL)-1, and IL-6 in mice with HD-induced obesity. BAB also attenuated changes associated with HD-induced colon inflammation, such as increased expression of proinflammatory cytokines. Moreover, BAB inhibited induction of nitric oxide synthase (iNOS), cyclooxygenase (COX)-2, and activation of nuclear factor-kappa B (NF-B) in the colon. Furthermore, BAB upregulated colon mRNA expression of tight junction-associated proteins such as claudin-1 and Zo-1, as well as mucosal barrier defense promoting genes such as mucin (Muc) 1 and Muc3. BAB also reduced macrophage infiltration into adipose tissue in mice with HD-induced intestinal inflammation. In LPS-stimulated peritoneal macrophages, treatment with BAB significantly decreased TNF- and NO production, NF-B activation, and iNOS expression. Our findings indicate that BAB ameliorates HD-induced disorders such as obesity and colitis by improving mucosal barrier protection and reducing endotoxemia, as well as by inactivating NF-B to decrease the production of proinflammatory cytokines.

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00:34

Bumps on The Back of Throat: What White, Red, Yellow, or Black Bumps Mean "IndyWatch Feed Health"

Bumps on the back of your throat usually mean that you have an infection or something has irritated your throat or tonsils. Red spots or dots, white patches, blister-like bumps or swollen lumps at the back of the throat can cause pain and discomfort. The throat bumps could also be a sign of swollen lymph glands due to a viral infection.

If you get a sore throat, there is a good chance that you or your doctor will notice red patches on your tonsils. You may also experience painful swallowing, notice white streaks of pus at the back of your throat, or have swollen tonsils. Along with symptoms of an infection at the back of your throat, you could also have a fever, headaches, and muscle aches.

In some cases, red, yellow, or black bumps at the back of your throat can be an indication of something more serious. If left untreated, some throat infections can cause serious complications. Infections can go deeper into your respiratory tract or affect other organs. Sometimes, black, white, or red spots or sores on your throat that dont go away need to be examined by a doctor.

In this article, you will learn about the various reasons why you have white, red or yellow bumps on your throat. You will also find out what it means if you notice black-colored bumps on the back of your throat.

What Are Bumps on Back of Throat

Back of the throat bumps that cause a sore throat can come in various shapes and sizes. Many viral or bacterial throat infections cause painful red spots that cause irritation. However, you might see that the bumps look more like blisters with or without pus.

If you have a yeast infection, then you will notice clumps of white bumps that are surrounded by red patches of inflamed skin.

Whatever type of bumps or lumps you have at the back of your throat, many home remedies can help to soothe the discomfort and treat the symptoms.

Symptoms of Bumps on Back of Throat

Because most causes of lumps and bumps on the back of your throat or tonsils are caused by an infection, you may have other symptoms.

If you are bothered by back of the throat lesions, one of the most common symptoms is discomfort and pain when swallowing. For example, some people say that the back of their throat feels like sandpaper when they swallow. When you look at the back of your throat, you may also notice tiny white spots or tiny red spots or dots.

Other symptoms of white or red bumps on the back of the throat can include any of the following:

00:33

Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2011 Oct 11 ;137(3):1197-206. Epub 2011 Aug 2. PMID: 21821108 Abstract Title:  Anti-inflammatory activity of ethanol extract derived from Phaseolus angularis beans. Abstract:  ETHNOPHARMACOLOGICAL SIGNIFICANCE: Phaseolus angularis Wight (adzuki bean) is an ethnopharmacologically well-known folk medicine that is prescribed for infection, edema, and inflammation of the joints, appendix, kidney and bladder in Korea, China and Japan.AIM OF STUDY: The anti-inflammatory effect of this plant and its associated molecular mechanisms will be investigated.MATERIALS AND METHODS: The immunomodulatory activity of Phaseolus angularis ethanol extract (Pa-EE) in toll like receptor (TLR)-activated macrophages induced by ligands such as lipopolysaccharide (LPS), Poly (I:C), and pam3CSK was investigated by assessing nitric oxide (NO) and prostaglandin (PG)E(2) levels. To identify which transcription factors such as nuclear factor (NF)-B and their signaling enzymes can be targeted to Pa-EE, biochemical approaches including reporter gene assays, immunoprecipitation, kinase assays, and immunoblot analyses were also employed. Finally, whether Pa-EE was orally available, ethanol (EtOH)/hydrochloric acid (HCl)-induced gastritis modelin mice was used.RESULTS: Pa-EE dose-dependently suppressed the release of PGE(2) and NO in LPS-, Poly(I:C)-, and pam3CSK-activated macrophages. Pa-EE strongly down-regulated LPS-induced mRNA expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2. Interestingly, Pa-EE markedly inhibited NF-B, activator protein (AP)-1, and cAMP response element binding protein (CREB) activation; further, according to direct kinase assays and immunoblot analyses, Pa-EE blocked the activation of the upstream signaling molecules spleen tyrosine kinase (Syk), p38, and transforming growth factor -activated kinase 1 (TAK1). Finally, orally administered Pa-EE clearly ameliorated EtOH/HCl-induced gastritis in mice.CONCLUSION: Our results suggest that Pa-EE can be further developed as a promising anti-inflammatory remedy because it targets multiple inflammatory signaling enzymes and transcription factors.

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00:29

Genistein exerts an immunomodulatory effect in a mouse model of Human Papillomavirus (HPV) associated-cervical cancer. "IndyWatch Feed Health"

PMID:  Iran J Immunol. 2012 Jun ;9(2):119-27. PMID: 22735799 Abstract Title:  Genistein induces a protective immunomodulatory effect in a mouse model of cervical cancer. Abstract:  BACKGROUND: Genistein (GEN), a naturally occurring flavonoid present in soy bean, has attracted scientific interest for its possible benefits in cancer.OBJECTIVE: The potential immunomodulatory effects of genistein on the immune system and against TC-1 tumor cell line were evaluated in adult female C57BL/6 mice.METHODS: Mice were treated with GEN 10 days before to 10 days after the tumor induction. Thirty days after the last GEN treatment, lymphocyte proliferation, Lactase Dehydrogenase (LDH) cytolytic activity and cytokine secretion were analyzed in GEN and control groups.RESULTS: The results showed that ingestion of genistein significantly increased lymphocyte proliferation and LDH release. Furthermore, the treatment with genistein also caused a significant increment in interferon gamma (IFN-). In addition, the treatment achieved significant therapeutic effect in tumor models compared to the control group. These results indicated that the effect of GEN on tumor growth may be attributed to its effect on lymphocyte proliferation, cytolytic activity and IFN- production.CONCLUSION: These results demonstrate that GEN exerts an immunomodulatory effect in a mouse model of Human Papillomavirus (HPV) associated-cervical cancer.

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00:24

A hemagglutinin from northeast red beans with immunomodulatory activity and anti-proliferative and apoptosis-inducing activities toward tumor cells. "IndyWatch Feed Health"

PMID:  Protein Pept Lett. 2013 Oct ;20(10):1159-69. PMID: 23514011 Abstract Title:  A hemagglutinin from northeast red beans with immunomodulatory activity and anti-proliferative and apoptosis-inducing activities toward tumor cells. Abstract:  A 64-kDa hemagglutinin from a Phaseolus vulgaris cultivar, the northeast red bean, was purified by a protocol composed of three chromatographic steps involving affinity chromatography on Affi-gel blue gel, cation exchange chromatography on SP-Sepharose and FPLC-gel filtration on Superdex 75. The purified hemagglutinin appeared as a single 32-kDa band in SDS-PAGE indicating its dimeric nature. The N-terminal amino acid sequence of the hemagglutinin resembled the sequences of lectins and hemagglutinins from a number of Phaseolus species. The hemagglutinin manifested moderate thermostability and pH stability. It retained full activity up to 65C and in the pH range 2-12. It did not interact with simple sugars such as glucose, mannose and galactose. The hemagglutinin exerted immunostimulatory effects by upregulating the expression of cytokines like interferon- and tumor necrosis factor-. It also exhibited antiproliferative activity on a number of tumor cells including MCF7 (breast cancer), HepG2 (liver cancer), CNE1 and CNE2 (nasopharyngeal cancer) cells, with stronger activity toward MCF7 and CNE1 cells. The hemagglutinin induced phophatidylserine externalization, mitochondrial depolarization and DNA condensation in MCF7 cells, indicating initiation of apoptosis. However, at high hemagglutinin concentrations, severe damage to the MCF7 cells was detected.

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00:19

These results suggested that fermented mung bean has potential cancer chemoprevention effects. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2013 ;2013:708464. Epub 2013 Apr 22. PMID: 23710232 Abstract Title:  In Vivo Immunomodulation and Lipid Peroxidation Activities Contributed to Chemoprevention Effects of Fermented Mung Bean against Breast Cancer. Abstract:  Mung bean has been reported to have antioxidant, cytotoxic, and immunomodulatory effects in vitro. Fermented products are reported to have enhanced immunomodulation and cancer chemopreventive effects. In this study, fermented mung bean treatments in vivo were studied by monitoring tumor development, spleen immunity, serum cytokine (interleukin 2 and interferon gamma) levels, and spleen/tumor antioxidant levels after injection with low and high risk 4T1 breast cancer cells. Pretreatment with fermented mung bean was associated with delayed tumor formation in low risk mice. Furthermore, this treatment was connected with higher serum anticancer cytokine levels, spleen T cell populations, splenocyte cytotoxicity, and spleen/tumor antioxidant levels. Histopathological evaluation of fermented mung bean treated tumor revealed lower event of mitotic division. On the other hand, antioxidant and nitric oxide levels that were significantly increased in the untreated mice were inhibited in the fermented mung bean treated groups. These results suggested that fermented mung bean has potential cancer chemoprevention effects through the stimulation of immunity, lipid peroxidation, and anti-inflammation.

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00:11

Mung bean proteins have the capacity to be regarded as a radio-sensitizer for breast cancer. "IndyWatch Feed Health"

PMID:  Int J Radiat Biol. 2018 Mar 19:1-10. Epub 2018 Mar 19. PMID: 29482484 Abstract Title:  The evaluation of radio-sensitivity of mung bean proteins aqueous extract on MCF-7, hela and fibroblast cell line. Abstract:  PURPOSE: Breast cancer is one of the most common malignant tumors in women all over the world. Many of these women resist the common treatments. Therefore, it is important to find new products to increase the efficacy of the treatment process. Legume beans, with their various pharmacological properties, can be regarded as a sensitizer when they are combined with radiation. The present study strove to survey the radio-sensitivity effect of proteins isolated from mung bean aqueous extract on the human breast adenocarcinoma cell line (MCF-7), human cervical cancer cells (Hela) and the human dermal fibroblast cell line.MATERIALS AND METHODS: The mung bean aqueous extract was partially purified by ammonium sulfate. At first, various concentrations of the extracts were used to evaluate the inhibitory activity by MTT cell proliferation assay.RESULTS: The results showed that MCF-7 cells and Hela cells were inhibited by an ICvalue of less than 250 and 411g/ml, respectively, but it proved to have a proliferation effect on the fibroblast cells. Then, the cells were incubated with 250g/ml extract and exposed to 2, 4, and 6Gy of X-ray radiation. The percentage of the cell survival was investigated through MTT and the clonogenic assay. Apoptosis was measured using acridine orange/ethidium bromide staining. The results demonstrated that the treated MCF-7 cells and Hela cells had significant radio-sensitivity compared with the results of the control group in radiation dose manner in all MTT, clonogenic, and apoptosis assays. In contrast,the treated fibroblast showed a protective effect against radiation.CONCLUSION: The results suggest that mung bean proteins have the capacity to be regarded as a radio-sensitizer for breast cancer. Our results also indicated that it could be worth to investigate on mung bean proteins further and they should be tested in animal models for being treated in radiotherapy.

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00:02

Black turtle bean extract exhibit anti-cancer activity by inducing apoptosis in breast cancer cell lines. "IndyWatch Feed Health"

PMID:  Chem Cent J. 2017 Jun 20 ;11(1):56. Epub 2017 Jun 20. PMID: 29086840 Abstract Title:  Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway. Abstract:  The black turtle bean (BTB) is most widely consumed legume all over the world having anticancer activity. The aim of the study was to analyse the apoptotic effects of BTB extracts on human breast cancer cell lines. Plant extract was prepared by homogenization and centrifugation. The cytotoxic effects of BTB was evaluated by MTT assay and their apoptotic effects were characterized by DNA fragmentation, nuclear staining assay, mitochondrial membrane potential analysis, annexin-V FITC and caspase 3/7 activity assay. The changes in cell cycle and gene expression of cell lines were analysed by flow cytometry and qRT-PCR, respectively. BTB extract showed cytotoxicity with ICvalues of 50 g/ml in MCF-7 and MDA-MB231 cells. The caspase 3/7 was activated in the cancer cells treated with BTB extract leading to cell death by apoptosis. Moreover, there was significant increase in the expression of Bax as well as decrease in the Bcl-2 and Bcl-xL expression with in a dose dependent manner in both cells. It induces cell cycle arrest in S and G2/M phase in MCF-7 and MDA-MB231 cells, respectively. The mitochondrial membrane potential was decreased in BTB treated cells thereby transducing the apoptotic signal through the mitochondrial pathway and it also causes DNA fragmentation. Thus, it can be concluded that BTB induces the apoptosis in MCF-7 and MDA-MB-231 cells through intrinsic and extrinsic pathway and can be explored further for promising candidate to combat breast cancer. BTB extract exhibit anti-cancer activity by inducing apoptosis in breast cancer cell lines.

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Wednesday, 18 April

23:50

A high dietary intake of bean fiber and fiber-rich foods such as beans and grains may lower the risk of ER-PR- breast cancer "IndyWatch Feed Health"

PMID:  Cancer Med. 2018 Mar 23. Epub 2018 Mar 23. PMID: 29573201 Abstract Title:  Intake of bean fiber, beans, and grains and reduced risk of hormone receptor-negative breast cancer: the San Francisco Bay Area Breast Cancer Study. Abstract:  High dietary fiber intake has been associated with reduced breast cancer risk, but few studies considered tumor subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status or included racial/ethnic minority populations who vary in their fiber intake. We analyzed food frequency data from a population-based case-control study, including 2135 breast cancer cases (1070 Hispanics, 493 African Americans, and 572 non-Hispanic Whites (NHWs)) and 2571 controls (1391 Hispanics, 557 African Americans, and 623 NHWs). Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer associated with fiber intake were calculated using unconditional logistic regression. Breast cancer risk associated with high intake (high vs. low quartile) of bean fiber (p-trend = 0.01), total beans (p-trend = 0.03), or total grains (p-trend = 0.05) was reduced by 20%. Inverse associations were strongest for ER-PR- breast cancer, with risk reductions associated with high intake ranging from 28 to 36%. For bean fiber, risk was reduced among foreign-born Hispanics only, who had the highest fiber intake, whereas for grain intake, inverse associations were found among NHWs only. There was no evidence of association with fiber intake from vegetables and fruits or total intake of vegetables and fruits. A high dietary intake of bean fiber and fiber-rich foods such asbeans and grains may lower the risk of ER-PR- breast cancer, an aggressive breast cancer subtype for which few risk factors have been identified.

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23:43

Leaked Memo Reveals Military Anthrax Vaccine Responsible for Injuries VA Claims Fake News "IndyWatch Feed Health"

Young military man getting an injection from nurse over light blue background

Comments by Brian Shilhavy
Editor, Health Impact News

Benjamin Krause is a lawyer, investigative reporter, award-winning veterans advocate, and the founder and chief editor of DisabledVeterans.org.

Krause recently published a leaked memo from the Department of the Army, admitting that during a 6-year period, from 2001 through 2007, many soldiers were vaccinated with a bad batch of the anthrax vaccine.

The purpose of the memo was to inform these veterans that they might be entitled to Veteran Affairs (VA) benefits due to the anthrax vaccine.

The memo leaked onto social media and allegedly prompted the Massachusetts Department of Veterans Services to address the memo, calling it a fake memo and a SCAM.

However, Krause reports that the memo was digitally signed and nearly impossible to fake:

A PDF of the memorandum, drafted by a person named Patrick McGrath II was digitally signed using a DOD certificate authority, and that its contents are not subject to repudiation because the certificate chain is intact, according to attorney Francis White, III, a former US Air Force compliance inspector for information technology.

I spoke with White, a colleague of mine in the same office, about his professional impression of the memo and his statement above.

White says faking the signature using a DOD CA certificate chain is nearly impossible in this context, the digital signature on that memo is valid and the related documentation shows it was signed by an individual named Patrick Steven McGrath II, and is not subject to repudiation

White says that does not mean McGrath had the authority to circulate the memo to the public, but it does show the memo cannot be summarily dismissed as fraudulent, c...

23:32

Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage. "IndyWatch Feed Health"

PMID:  J Nutr Biochem. 2018 Feb 27 ;56:215-223. Epub 2018 Feb 27. PMID: 29631142 Abstract Title:  Navy and black bean supplementation attenuates colitis-associated inflammation and colonic epithelial damage. Abstract:  The enriched levels of nondigestible fermentable carbohydrates and phenolic compounds found in common beans can exert immunomodulatory effects within the colon that improve gut health and mitigate the severity of colitis-associated inflammatory pathology. Prior to acute colitis onset, C57Bl/6 mice were prefed isocaloric 20% cooked navy bean (NB) or black bean (BB) diets for 3 weeks and switched to control basal diet (BD) 24 h prior to colitis induction via 5-day exposure to dextran sodium sulfate (2% w/v in drinking water)+3 days of fresh water. The severity of the acute colitis phenotype was attenuated by bean prefeeding, evidenced by reduced colon tissue inflammatory transcription factor activation (NFB, STAT3) and inflammatory mediator levels in the colon (IL-1, IL-6, IL-18 and MCP-1) and serum (TNF, IL-6, IL-1, MCP-1) versus BD (P.05). Additionally, biomarkers of enhanced wound repair responses were increased by bean prefeeding including colon tissue protein levels of IL-22, IL-27 and activated (i.e., GTP-bound) Cdc42 and Rac1 versus BD (P.05). mRNA expressions of genes involved in normal colonic epithelial function and the promotion of epithelial barrier integrity, defense and/or restitution and wound closure including MUC1, RELM, IgA and REG3 were all increased in NB and BB prefed mice versus BD (P.05). Collectively, bean supplementation prior to colitis induction (i.e., mimicking disease relapse) primes the colonic microenvironment to attenuate the severity of the colitis inflammatory phenotype and maintain aspects of epithelial barrier function.

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23:30

Study: Cholesterol-Lowering Statin Drugs Increase Risk of ALS Lou Gehrigs Disease "IndyWatch Feed Health"

statins-box

by Paul Fassa
Health Impact News

A recent study connecting increased statin drug use with rising ALS was discussed by Dr. Malcom Kendrick. He had followed earlier similar studies with similar concerns, but this one confirmed Dr. Kendricks suspicions.

ALS (Amyotrophic lateral sclerosis), is also known as motor neuron disease (MND), or Lou Gehrigs disease.

It is a progressive neurological disease that destroys neurons in nerves that extend laterally from the spine, thus the word lateral is part of its description. Sclerosis means scarring or hardening, which incapacitates the nerves leading to a loss of muscle control. The term Amyotrophic is a combination of Latin/Greek syllables that means no muscle nourishment leading to complete atrophy.

But the loss of motor control from lateral movement neuron damage progresses to losing the ability to partially or fully physically function in many areas required of the human body, such as walking, talking, eating, walking, and even breathing.

ALS patients can die while slowly suffocating. (Source)

Ones mind normally remains lucid while experiencing ALS. Dr. Kendrick mentions that ALS suffering can be so severe, especially in the late stage of breathing difficulty, that many ALS patients resort to finding places where assisted suicide is allowed to avoid slowly suffocating to death.

The Recent Statin Drug Study Discussed by Dr. Kendrick

The study of concern is Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDAs Adverse Event Reporting System. It was published by the journal Drug Safety in April of 2018.

The researchers at the University of California (San Diego) and Advera Health Analytics, Inc., Santa Rosa, California teamed up to analyze data from the FDA Adverse Event Reporting System (FAERS) to determine what is known as reporting odds ratios...

23:19

Therapeutic cannabinoids in multiple sclerosis. "IndyWatch Feed Health"

PMID:  Eur J Neurol. 2018 Apr 10. Epub 2018 Apr 10. PMID: 29633480 Abstract Title:  Therapeutic cannabinoids in multiple sclerosis: immunomodulation revisited. Abstract:  Cannabinoids are compounds with pleiotropic properties that act on the cannabinoid receptors, CB1 and CB2, and are divided into endocannabinoids, the endogenous ligands of these receptors, synthetic cannabinoids and phytocannabinoids. The latter are derived from the plant Cannabis sativa. The therapeutic and psychoactive properties of this plant have been observed and used for centuries. Of the over 60 compounds that are unique to Cannabis sativa, the substances that have been attributed the greatest therapeutic potential are- tetrahydrocannabinol (THC) and cannabidiol (CBD), both of which, used alone or combined with each other, have become approved drugs. This article is protected by copyright. All rights reserved.

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23:15

Scientific evidence for the alleviation of osteoarthritis pain by cannabinoids. "IndyWatch Feed Health"

PMID:  Curr Opin Pharmacol. 2018 Apr 7 ;40:104-109. Epub 2018 Apr 7. PMID: 29635215 Abstract Title:  Cannabis and joints: scientific evidence for the alleviation of osteoarthritis pain by cannabinoids. Abstract:  Cannabis has been used for millennia to treat a multitude of medical conditions including chronic pain. Osteoarthritis (OA) pain is one of the most common types of pain and patients often turn to medical cannabis to manage their symptoms. While the majority of these reports are anecdotal, there is a growing body of scientific evidence which supports the analgesic potential of cannabinoids to treat OA pain. OA pain manifests as a combination of inflammatory, nociceptive, and neuropathic pain, each requiring modality-specific analgesics. The body's innate endocannabinoid system (ECS) has been shown to ameliorate all of these pain subtypes. This review summarizes the components of the ECS and details the latest research pertaining to plant-based and man-made cannabinoids for the treatment of OA pain. Recent pre-clinical evidence supporting a role for the ECS to control OA pain is described as well as current clinical evidence of the efficacy of cannabinoids for treating OA pain in mixed patient populations.

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23:09

Iron Supplements Grow Cancer Cells Throw Them Away "IndyWatch Feed Health"

Iron Supplements Grow Cancer Cells - Throw Them Away

By Heather CallaghanEditor

As much as we support supplement freedom in the U.S., there are some very questionable supplements on the market. Some are made from rocks, hair or metals. Iron can build up in the system and become toxic so we are going to have to wave them goodbye. We forget sometimes that iron is a heavy metal, after all. We need a little, not a lot.

According to a new study of cancer cells from Chalmers University of Technology, Sweden, two common iron compounds increase the formation of a known cancer biomarker.

The two compounds, ferric citrate and ferric EDTA, are often used in dietary supplements and as a food additive in the USA and the EU. They are commonly a part of fortified foods, but the types of iron used are rarely listed on supplement bottles or ingredients lists.

Currently, there are many different types of iron supplements on the market. These can be based on at least 20 different iron compounds, and sold under a wide range of brands.

Here, we talk about what iron does in the lab and what you can you do if you need more iron.

Chalmers University reported:

The researchers studied ferric citrate and ferric EDTA, which have both previously been shown to worsen tumour formation in mice with colon cancer. The science behind this has been...

23:06

Chronic pain treatment with cannabidiol in kidney transplant patients in Uruguay. "IndyWatch Feed Health"

PMID:  Transplant Proc. 2018 Mar ;50(2):461-464. PMID: 29579828 Abstract Title:  Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay. Abstract:  BACKGROUND: Chronic pain is a major therapeutic problem in kidney transplant patients owing to nephrotoxicity associated with nonsteroidal antiiflammatory drugs. Benefits in chronic pain treatment with cannabidiol (CBD) have been reported. This study assesses the effect, safety, and possible drug interactions in kidney transplant patients treated with CBD for chronic pain.METHODS: We assessed patients who asked to receive CBD for pain treatment. Doses were increased from 50 to 150 mg twice a day for 3 weeks. Creatinine, blood count, liver function, liver enzymes, and drug levels were determined every 48 hours the first week and then once a week thereafter.RESULTS: We assessed 7 patients with a mean age of 64.5 years (range, 58-75 years). CBD initial dose was 100 mg/d, CBD dose reduction to 50 mg/d has been done on day 4 to patient 1 for persistent nausea. Tacrolimus dose reduction in patient 3 was undertaken on days 4, 7, and 21 owing to persisting elevated levels (even before CBD) and itching, and on day 21 in patient 5. Tacrolimus levels decreased in patient 2 but were normal in the control 1 week later. Patients on cyclosporine were stable. Adverse effects were nausea, dry mouth, dizziness, drowsiness, and intermittent episodes of heat. CBD dose decrease was required in 2 patients. Two patients had total pain improvement, 4 had a partial response in the first 15 days, and in 1 there was no change.CONCLUSIONS: During this follow-up, CBD was well-tolerated, and there were no severe adverse effects. Plasma levels of tacrolimus were variable. Therefore, longer follow-up is required.

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22:50

This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of allergic contact dermatitis. "IndyWatch Feed Health"

PMID:  J Pharmacol Exp Ther. 2018 Apr 9. Epub 2018 Apr 9. PMID: 29632236 Abstract Title:  Anti-inflammatory properties of cannabidiol, a non-psychotropic cannabinoid, in experimental allergic contact dermatitis. Abstract:  Phytocannabinoids modulate inflammatory responses by regulating the production of cytokines in several experimental models of inflammation. Cannabinoid type-2 (CB2) receptor activation was shown to reduce the production of the monocyte chemotactic protein-2 (MCP-2) chemokine in polyinosinic-polycytidylic acid [poly-(I:C)]-stimulated human keratinocyte (HaCaT) cells, an in vitro model of allergic contact dermatitis (ACD). We investigated if non-psychotropic cannabinoids like cannabidiol (CBD) produced similar effects in this experimental model of ACD. HaCaT cells were stimulated with poly-(I:C) and the release of chemokines and cytokines was measured in the presence of CBD or other phytocannabinoids (such as CBDA, CBDV, CBDVA, CBC, CBG, CBGA, CBGV, THCV, THCVA) and antagonists of cannabinoid type-1 (CB1), CB2 or transient receptor potential vanilloid type 1 (TRPV1) receptors. HaCaT cell viability following phytocannabinoid treatment was also measured. The cellular levels of endocannabinoids [anandamide (AEA), 2-arachidonoylglycerol (2-AG)] and related molecules [palmitoylethanolamide (PEA), oleoylethanolamide (OEA)] were quantified in poly-(I:C)-stimulated HaCaT cells treated with CBD. We showed that in poly-(I:C)-stimulated HaCaT cells, CBD elevated the levels of AEA and dose-dependently inhibited poly-(I:C)-induced release of MCP-2, IL-6, IL-8 and TNF- in a manner reversed by CB2 and TRPV1 antagonists, AM630 and I-RTX, respectively, with no cytotoxic effect. This is the first demonstration of the anti-inflammatory properties of CBD in an experimental model of ACD.

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22:39

Manuka honey induces HCT-116 and LoVo cell death partly by enhancing oxidative stress. "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Apr 12. Epub 2018 Apr 12. PMID: 29644357 Abstract Title:  The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 2: Induction of oxidative stress, alteration of mitochondrial respiration and glycolysis, and suppression of metastatic ability. Abstract:  Despite its high content of phenolic compounds, the chemopreventive activity of Manuka honey (MH) is still elusive. The aim of the present work was to evaluate the effects of MH on oxidative stress, antioxidant enzymes, cellular metabolism and the metastatic ability in HCT-116 and LoVo cells, paying particular attention to the molecular mechanisms involved. We observed a strong induction of oxidative stress after MH treatment since it augmented the accumulation of reactive oxygen species and increased the damage to proteins, lipids and DNA. Furthermore, MH suppressed the Nrf2-dependent antioxidant enzyme expression (superoxide dismutase (SOD), catalase and heme oxygenase-1) and the activity of SOD, catalase, glutathione peroxidase and glutathione reductase. Cell metabolisms were markedly disrupted after MH treatment. It decreased maximal oxygen consumption and spare respiratory capacity, which could reduce the mitochondrial function that is correlated with cell survival potential. Simultaneously, MH decreased the extracellular acidification rate (glycolysis) of HCT-116 and LoVo cells. Furthermore, MH suppressed the p-AMPK/AMPK, PGC1 and SIRT1 activation, involved in the survival of HCT-116 and LoVo cells under metabolic stress conditions. Dose-dependently, MH reduced the migration and invasion (MMP-2 and MMP-9) ability, and concurrently regulated EMT-related markers (E cadherin, N cadherin, and -catenin) in both cell types. The above findings indicate that MH induces HCT-116 and LoVo cell death partly by enhancing oxidative stress, as well as by regulating the energy metabolism in both aerobic and anaerobic pathways and suppressing the metastatic ability.

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22:38

Leaked Memo Reveals Military Anthrax Vaccine Responsible for Injuries VA Claims Fake News "IndyWatch Feed Health"

Young military man getting an injection from nurse over light blue background

Comments by Brian Shilhavy
Editor, Health Impact News

Benjamin Krause is a lawyer, investigative reporter, award-winning veterans advocate, and the founder and chief editor of DisabledVeterans.org.

Krause recently published a leaked memo from the Department of the Army, admitting that during a 6-year period, from 2001 through 2007, many soldiers were vaccinated with a bad batch of the anthrax vaccine.

The purpose of the memo was to inform these veterans that they might be entitled to Veteran Affairs (VA) benefits due to the anthrax vaccine.

The memo leaked onto social media and allegedly prompted the Massachusetts Department of Veterans Services to address the memo, calling it a fake memo and a SCAM.

However, Krause reports that the memo was digitally signed and nearly impossible to fake:

A PDF of the memorandum, drafted by a person named Patrick McGrath II was digitally signed using a DOD certificate authority, and that its contents are not subject to repudiation because the certificate chain is intact, according to attorney Francis White, III, a former US Air Force compliance inspector for information technology.

I spoke with White, a colleague of mine in the same office, about his professional impression of the memo and his statement above.

White says faking the signature using a DOD CA certificate chain is nearly impossible in this context, the digital signature on that memo is valid and the related documentation shows it was signed by an individual named Patrick Steven McGrath II, and is not subject to repudiation

White says that does not mean McGrath had the authority to circulate the memo to the public, but it d...

22:28

Manuka honey could be a promising preventive or curative food therapy for colon cancer. "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Apr 12. Epub 2018 Apr 12. PMID: 29645049 Abstract Title:  The inhibitory effect of Manuka honey on human colon cancer HCT-116 and LoVo cell growth. Part 1: the suppression of cell proliferation, promotion of apoptosis and arrest of the cell cycle. Abstract:  Numerous investigations have been made on plant phenolic compounds and cancer prevention in recent decades. Manuka honey (MH) represents a good source of phenolic compounds such as luteolin, kaempferol, quercetin, gallic acid and syringic acid. The aim of this work was to evaluate the chemopreventive effects of MH on human colon cancer HCT-116 and LoVo cells. Both cells were exposed to different concentrations of MH (0-20 mg mL-1 for HCT-116 cells and 0-50 mg mL-1 for LoVo cells) for 48 h to measure apoptosis and cell cycle arrest as well as apoptosis and cell cycle regulatory gene and protein expression. MH exhibited profound inhibitory effects on cellular growth by reducing the proliferation ability, inducing apoptosis and arresting the cell cycle in a dose-dependent manner. Interestingly, MH treatment in non-malignant cells did not exert any significant toxicity at similar concentrations. The apoptosis event was associated with the increasing expression of p53, cleaved-PARP and caspase-3 and with the activation of both intrinsic (caspase-9) and extrinsic (caspase-8) apoptotic pathways. MH induced cell cycle arrest in the S phase in HCT-116 cells, and simultaneously, in LoVo cells, it occurred in the G2/M phase through the modulation of cell cycle regulator genes (cyclin D1, cyclin E, CDK2, CDK4, p21, p27 and Rb). The expression of p-Akt was suppressed while the expression of p-p38MAPK, p-Erk1/2 and endoplasmic stress markers (ATF6 and XBP1) was increased for apoptosis induction. Overall, these findings indicate that MH could be a promising preventive or curative food therapy for colon cancer.

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22:12

These results suggest that alcohol, morphine, and morphine+alcohol co-treatment may trigger cognitive deficits and inflammatory responses in the brain. "IndyWatch Feed Health"

PMID:  Anat Cell Biol. 2018 Mar ;51(1):41-51. Epub 2018 Mar 28. PMID: 29644109 Abstract Title:  Morphine-alcohol treatment impairs cognitive functions and increases neuro-inflammatory responses in the medial prefrontal cortex of juvenile male rats. Abstract:  In the developed and developing world, opioid consumption in combination with alcohol has become one of the substances abused. In this experiment, we examined the effects of alcohol, morphine, and morphine+alcohol combination on cognitive functions and neuroinflammatory responses in the medial prefrontal cortex (mPFC) of juvenile male rats. Alcohol (1.0 ml of 15% v/v ethanol twice daily, subcutaneously, 7 hours apart), morphine (0.5 ml/kg of 0.4 mg/kg morphine chlorate twice daily, subcutaneously, 7 hours apart), morphine+alcohol co-treatment (0.5 ml/kg of 0.4 mg/kg morphine chlorate+1.0 ml of 15% v/v ethanol twice daily, subcutaneously, 7 hours apart) were administered for 21 days. Treatment with morphine+alcohol significantly impairs cognition functions in the Morris water maze, passive avoidance, and novel object recognition tests, furthermore, the treatment significantly increased the quantitative count of astrocytic cells and also conferred marked neuronal cell death in the mPFC, which were studied by glial fibrillary acidic protein immunochemistry for astrocytes and Cresyl violet for Nissl's substance distribution in neurons respectively. These results suggest that alcohol, morphine, and morphine+alcohol co-treatment may trigger cognitive deficits and neuroinflammatory responses in the brain.

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22:04

Broad bean pods may be an effective functional food for the management of diabetes and its complications. "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Mar 28. Epub 2018 Mar 28. PMID: 29589631 Abstract Title:  Broad bean (Vicia faba L.) pods: a rich source of bioactive ingredients with antimicrobial, antioxidant, enzyme inhibitory, anti-diabetic and health-promoting properties. Abstract:  This study was aimed at investigating the chemical composition (proximate, minerals, fatty acids and phenolic compounds) and the in vitro (antimicrobial, radical scavenging, anti-acetylcholinesterase and protein denaturing activities) and in vivo (anti-diabetic and histo-protective effects in alloxan-induced diabetic mice) biological activities of broad bean pods (BBPs), a food waste by-product material. The results showed that BBPs have high dietary fiber (57.46%), carbohydrate (18.93%) and protein (13.81%) content versus low fat content (

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21:39

Batterys hidden layer revealed "IndyWatch Feed Health"

The reaction mechanism for converting hydrogen fluoride (HF) impurity from the electrolyte into lithium fluoride (LiF) in the solid-electrolyte interphase (SEI) with release of hydrogen gas (H2). The SEI layer is shown on a substrate of gold (Au) atoms, which serves as a simplified model system. Scientists determined this mechanism using advanced computational methods (density functional theory and molecular dynamics simulations). Credit: Argonne National Laboratory>
_______________________________________________
Commercially available since the 1970s, the lithium-ion battery is now the workhorse power source in many applications. It can be found in cell phones, laptops and electric vehicles. Yet, much about the basic science taking place at the atomic and molecular levels during charge and discharge remains a mystery.

In a new study published in Nature Catalysis, a team at the U.S. Department of Energys (DOE) Argonne National Laboratory reports a breakthrough in understanding the chemistry of the microscopically thin layer that forms at the interface between the liquid electrolyte and solid electrode. Battery researchers commonly refer to this layer as the solid-electrolyte interphase or SEI.

Much scientific work over the last several decades has been devoted to understanding the SEI in the lithium-ion . Scientists know that the SEI forms on the graphite negative electrode, is extremely thin (less than a thousandth of a millimeter), and primarily takes shape during the first charge of the battery. Also well-established is that the SEI prevents detrimental reactions from occurring at the interface, while at the same time allowing the important lithium ions free rein to move between the electrolyte and electrode.

All good

21:31

Drinking May Have Given Me Cancer. The Alcohol Industry Has Worked Hard to Bury the Link "IndyWatch Feed Health"

Stephanie Mencimer is a 47-year-old writer.  By all her accounts, she had taken the necessary steps to be free and clear of breast cancer.  Careful diet, exercise, BPA free water bottles and breastfeeding her children were all part of Stephanies regimen.  Additionally, Stephanie was a decade and a half younger than the median age for... View Article

The post Drinking May Have Given Me Cancer. The Alcohol Industry Has Worked Hard to Bury the Link appeared first on Healthy Holistic Living.

21:23

Topical Aloe vera gel significantly demonstrated accelerated split-thickness skin graft donor site healing. "IndyWatch Feed Health"

PMID:  Plast Reconstr Surg. 2018 Mar 30. Epub 2018 Mar 30. PMID: 29649056 Abstract Title:  Topical Aloe Vera Gel for Accelerated Wound Healing of Split-Thickness Skin Graft Donor Sites: A Double-Blind, Randomized, Controlled Trial and Systematic Review." Abstract:  BACKGROUND: Aloe vera has been used to treat wounds since ancient times. However, the efficacy of Aloe vera for burns and split-thickness skin graft (STSG) donor sites are inconclusive.METHODS: A double-blind, randomized, controlled trial was conducted. Patients who underwent STSG harvesting from the thigh were included. STSG donor sites were divided into two groups: Aloe vera group and placebo group. The visual analogue scale (VAS) score evaluated pain and complete epithelialization was assessed. We searched electronic databases and included only international clinical trials published in the English language.RESULTS: Twelve patients with 24 donor sites participated. Times to complete epithelization for the Aloe vera and placebo groups were 11.5 + 1.45 and 13.67 + 1.61 days (p

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21:16

The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms. "IndyWatch Feed Health"

PMID:  Clujul Med. 2017 ;90(3):344-347. Epub 2017 Jul 15. PMID: 28781531 Abstract Title:  Antibacterial and antifungal activity of endodontic intracanal medications. Abstract:  BACKGROUND AND AIMS: The sterilization of the entire root canal system represents the main goal of every endodontist, given the fact that the control of the microbial flora is the key point of every root canal treatment. The diversity of microorganisms found inside the root canal and also the resistance of some bacterial species to intracanal medications led to a continuous development of new endodontic products. The present study focuses on the comparison of the antibacterial and antifungal properties of different endodontic products, two commercially available, one experimental plant based extract, and two control substances.METHODS: The disc diffusion assay was used to determine the antibacterial and antifungal properties of chlorhexidine, calcium hydroxide, a mix extract between Arctium lappa root powder and Aloe barbadensis Miller gel, Amoxicillin with clavulanic acid and Fluconazole (as control substances). Two of the most common microorganisms found in endodontic infections were chosen: Enterococcus faecalis (ATCC 29212) and Candida albicans ATCC(10231).RESULTS: All tested substances showed inhibition zones around the discs, for Enterococcus faecalis and Candida albicans, including the experimental mix extract of Arctium lappa root powder with Aloe vera gel.CONCLUSION: The experimental mix extract of Arctium lappa root powder and Aloe vera gel is able to inhibit very resistant microorganisms, like Enterococcus faecalis and Candida albicans.

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20:46

The effects of hypoglycemia and weight loss of total lignans from Fructus Arctii in KKAy mice and its mechanisms of the activity. "IndyWatch Feed Health"

PMID:  Phytother Res. 2018 Apr ;32(4):631-642. Epub 2017 Dec 13. PMID: 29235180 Abstract Title:  The effects of hypoglycemia and weight loss of total lignans from Fructus Arctii in KKAy mice and its mechanisms of the activity. Abstract:  Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0.5% sodium carboxymethyl cellulose), TLFA (250 and 125 mg/kg), or metformin (200 mg/kg) for 11 weeks, and C57BL/6J mice treated with saline solution (0.9%, w/v) were used as normal control. The results indicate that TLFA has dual effects of hypoglycemia and weight loss, and administration of TLFA in KKAy mice could decrease fasting blood glucose, glycated hemoglobin, and body weight; improve oral glucose tolerance; increase high density lipoprotein cholesterol; and decrease triglycerides and free fatty acid in mice serum. Its efficacy may associate with multiple mechanisms of action such as stimulation of insulin secretion, activation of phosphatidylinositol 3-kinase/protein kinase B, and adenosine-monophosphate-activated protein kinase signaling pathway, decreasing leptin.

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20:40

Rain Barrels Available at Discounted Rate for New Bedford Residents "IndyWatch Feed Health"

NEW BEDFORD This spring, rainwater collection barrels offered by The Great American Rain Barrel Company will be available for residents of New Bedford.

Harvesting rainwater with a rain barrel can mitigate the irregular patterns of rainfall. To help homeowners and the City manage their water supplies and encourage water conservation, New Bedford is offering residents the opportunity to purchase rain barrels at a discount.

Saving rainwater helps homeowners hedge against the cost of water. Rainwater is a free healthy alternative; it is organic, has no chloramine, no fluoride and no chemicals. It is an excellent water source for plants, gardens, lawns and any non-potable use.

Regular use of a rain barrel can pay for itself in one season. One tenth of an inch of rain on a 1000-square-foot roof about 25 minutes of moderate rainfall will fill a 60-gallon rain barrel. New England typically receives 17 inches of rain during the growing season from May through September. This provides enough water to fill 170 rain barrels. At 2.78 cents per gallon, homeowners can expect to save about $280 worth of water (based on current New Bedford water rates).

Droughts stress residential landscaping and town water facilities; in 2016, 168 communities in Massachusetts faced restrictions on nonessential outdoor water use a full 47% of the cities and towns in the state. There is no restriction on rainwater use.

The Great American Rain Barrel Co., a local food importing company, has been repurposing shipping drums into Rain Barrels since 1988. Last year, 30 percent of Massachusetts cities and towns partnered with The Great American Rain Barrel Co, selling over 3000 barrels. The Great American Rain Barrel Co. has been approved as vendors by the Massachusetts Department of Environmental Protection (DEP) for the state since 2010.

Barrels are being offered to residents for $69 a savings of 40 percent off the retail price. To learn more about the barrels, and to order a barrel, please visit: www.greatamericanrainbarrel.com/community and select New Bedford. Residents may also order a barrel by calling 1-800-251-2352. The deadline to order barrels is Sunday, April 29.

Once ordered, the barrels will be available for pick up on Saturday, May 5 at the New Bedford Department of Public Infrastructures office at 1103 Shawmut Avenue in New Bedford from 9 a.m. to 11 a.m.

About The Great American Rain Barrel Co.:

100% re-purposed rain barrels produced in Massachusetts.

Most d...

20:30

Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways. "IndyWatch Feed Health"

PMID:  J Pharmacol Sci. 2017 Nov ;135(3):97-104. Epub 2017 Aug 10. PMID: 29108833 Abstract Title:  Arctiin protects against cardiac hypertrophy through inhibiting MAPKs and AKT signaling pathways. Abstract:  PURPOSE: The mitogen-activated protein kinases (MAPKs) and protein kinase B (AKT) pathways have emerged as essential intracellular signaling pathways in eukaryotic cells, particularly as regulators of cardiac hypertrophy. Previous studies indicated that arctiin, an active ingredient of biennial dried ripe burdock, could exhibit potent anti-inflammatory and anti-allergic activities via down-regulating the activation of MAPKs and AKT pathways. However, little is known about its effects on cardiac hypertrophy. Therefore, the present study aimed to explore whether arctiin could attenuate cardiac hypertrophy.GENERAL METHODS: Arctiin (80 mg/kg) was administered by oral gavage once daily for 3 weeks from 1 week after surgery. Then, the mice were subjected to either chronic pressure overload generated by aortic banding (AB) or sham surgery (control group). Cardiac function was assessed by echocardiography.FINDINGS: The results indicated that arctiin attenuated cardiac hypertrophy induced by AB, and suppressed cardiac fibrosis and accumulation of collagen in vivo. Arctiin also inhibit the activation of MAPKs and AKT occurs in response to hypertrophic stimuli. Arctiin attenuated phenylephrine-induced hypertrophy of myocytes in vitro.CONCLUSIONS: In conclusion, arctiin can improve cardiac function and prevent the development of cardiac hypertrophy by blocking the MAPKs and AKT signaling pathways.

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20:24

Arctiin protected the UVB radiationmediated decrease in COL1A1 mRNA expression. "IndyWatch Feed Health"

PMID:  Mol Med Rep. 2017 Dec ;16(6):9120-9124. Epub 2017 Oct 2. PMID: 28990056 Abstract Title:  Arctiin regulates collagen type 1 chain 1 mRNA expression in human dermal fibroblasts via the miR378bSIRT6 axis. Abstract:  Arctiin, a lignin isolated from Arctium lappa, exhibits a variety of biological effects, including antiviral, antiinflammatory, and antiproliferative actions, in mammalian cells. In a previous study, arctiin was demonstrated to induce procollagen type I synthesis and exhibited protective effects against ultraviolet B (UVB) radiation in normal human dermal fibroblasts (nHDFs). However, the underlying molecular mechanism of arctiinmediated collagen synthesis remains unknown. In the present study, the mechanism for increased expression of collagen type 1 1 chain (COL1A1) mRNA in arctiininduced nHDFs was identified. The expression of microRNA378b (miR378b), downregulated by arctiin, was correlated with the expression of sirtuin6 (SIRT6) mRNA, a regulator of COL1A1 mRNA. Furthermore, it was revealed that arctiin protected the UVB radiationmediated decrease in COL1A1 mRNA expression, through the miR378b/SIRT6 signaling pathway. In conclusion, these results suggest that arctiin regulates COL1A1 through the miR378bSIRT6 axis.

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20:23

Spring Cleaning The Liver "IndyWatch Feed Health"

By Rosanne Lindsay, ND

Spring has sprung!  Tis the season for rebirth and regeneration. Spring is ruled by the wood element which is associated with the liver and its complementary organ, the gallbladder.  What better time to reset and rejuvenate body, mind, and spirit than through the liver, an organ known to regenerate itself if a portion is surgically removed?

It was at one time considered the seat of life; hence its name liver, the thing we live with. -Ambrose Bierce, The Devils Dictionary, Tales and Memoirs

As the bodys largest filter and gland, the liver is a detox powerhouse responsible for more than 500 (possibly 5000) functions. Your liver filters 1 liter of blood every minute from the digestive tract before it flows to the rest of the body. It holds about one pint of blood (13% of the bodys blood) at any given moment. It detoxifies, nourishes, replenishes, and stores blood. It also energizes the blood by releasing stored sugar (glycogen) as glucose. Other jobs of your liver include:

  • metabolizing drugs and detoxing chemicals,
  • synthesizing glutathione, an important antioxidant that removes toxins (heavy metals and chemicals),
  • converting sunlight to vitamin D3, critical to the immune system function,
  • producing bile, which helps break down fats in the small intestine during digestion, and carry away wastes,
  • making amino acids which become protein,
  • converting T4 thyroid hormone to T3,
  • making steroid and sex hormones that affect libido, menstrual cycle, and timing of menopause,
  • creating digestive enzymes and immune cells, and storing vitamins.

The liver is also...

20:21

Duty to Warn - The Painful Truth About Last Year's Failed Flu Vaccine "IndyWatch Feed Health"

There are three kinds of lies: lies, damned lies, and statistics. Mark Twain

most flu appears to have nothing to do with influenza. Every year, hundreds of thousands of respiratory specimens are tested across the US. Of those tested, on average 16% are found to be influenza positive. From the British Medical Journal editor, Peter Doshi, MD

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20:17

Supplementation with burdock has a wide spectrum of bioactive effects, including health promotion, performance improvement, and fatigue reduction. "IndyWatch Feed Health"

PMID:  J Vet Med Sci. 2017 Oct 7 ;79(10):1698-1706. Epub 2017 Sep 11. PMID: 28890521 Abstract Title:  Effect of burdock extract on physical performance and physiological fatigue in mice. Abstract:  : Burdock (BD) is a common vegetable with many pharmacological properties. However, few studies have examined the effect of BD on exercise performance and physical fatigue. We aimed to evaluate the potential beneficial effects of BD on fatigue and ergogenic functions following physical challenge in mice.METHODS: Male ICR mice were divided into four groups to receive either vehicle, or BD at 348.5, 697 or 1,742.5 mg/kg/day, by daily oral gavage for 4 weeks. Exercise performance and fatigue were evaluated from forelimb grip strength, exhaustive swimming time, and post-exercise levels of physical fatigue-related biomarkers serum lactate, ammonia, glucose, and creatine kinase (CK).RESULTS: BD supplementation elevated endurance and grip strength in a dose-dependent manner. It also significantly decreased lactate, ammonia, and CK levels after physical challenge. In addition, BD supplementation had few subchronic toxic effects.CONCLUSIONS: Supplementation with BD has a wide spectrum of bioactive effects, including health promotion, performance improvement, and fatigue reduction.

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20:05

Resveratrol induces mitochondrial apoptosis and inhibits epithelial-mesenchymal transition in oral squamous cell carcinoma cells. "IndyWatch Feed Health"

PMID:  Nutr Cancer. 2018 Jan ;70(1):125-135. Epub 2017 Nov 17. PMID: 29148840 Abstract Title:  Resveratrol Induces Mitochondrial Apoptosis and Inhibits Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma Cells. Abstract:  OSCC is the most common malignant cancer of the head and neck. EMT is an essential cellular process critical to the morphogenesis and homeostasis of solid tissues. It is also involved in the initial stage of cancer metastasis and invasion in which cells lose epithelial characteristics. While cancer therapy protocols such as surgery, radiation, and chemotherapy are effective and useful, the drug tolerance and toxicity of OSCC patients remain a problem. Resveratrol is mainly produced in red grape skin and exhibits anti-oxidative, anti-inflammatory, anti-proliferative, and anti-cancer properties. This study was undertaken to investigate the underlying mechanisms giving rise to the induction of apoptosis by resveratrol in the human tongue squamous cell carcinoma cell line. Resveratrol treatment resulted in a time- and dose-dependent decrease in cell viability and increased the apoptotic cell ratio in CAL-27, SCC15, and SCC25 cells. Resveratrol treatment of CAL-27 cells showed that several lines of apoptotic manifestation and decreased cell migration, invasion, and EMT-inducing transcription factor. Taken together, our findings demonstrate the inhibitory effect of resveratrol in human OSCC cells via the mitochondrial pathway and that resveratrol is able to inhibit cell invasion and migration by inhibiting the EMT-inducing transcription factors.

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19:46

Chemotherapy induces enrichment of immune evasive triple-negative breast cancer cells. "IndyWatch Feed Health"

PMID:  Proc Natl Acad Sci U S A. 2018 Feb 6 ;115(6):E1239-E1248. Epub 2018 Jan 24. PMID: 29367423 Abstract Title:  Chemotherapy induces enrichment of CD47/CD73/PDL1immune evasive triple-negative breast cancer cells. Abstract:  Triple-negative breast cancer (TNBC) is treated with cytotoxic chemotherapy and is often characterized by early relapse and metastasis. To form a secondary (recurrent and/or metastatic) tumor, a breast cancer cell must evade the innate and adaptive immune systems. CD47 enables cancer cells to evade killing by macrophages, whereas CD73 and PDL1 mediate independent mechanisms of evasion of cytotoxic T lymphocytes. Here, we report that treatment of human or murine TNBC cells with carboplatin, doxorubicin, gemcitabine, or paclitaxel induces the coordinate transcriptional induction of CD47, CD73, and PDL1 mRNA and protein expression, leading to a marked increase in the percentage of CD47CD73PDL1breast cancer cells. Genetic or pharmacological inhibition of hypoxia-inducible factors (HIFs) blocked chemotherapy-induced enrichment of CD47CD73PDL1TNBC cells, which were also enriched in the absence of chemotherapy by incubation under hypoxic conditions, leading to T cell anergy or death. Treatment of mice with cytotoxic chemotherapy markedly increased the intratumoral ratio of regulatory/effector T cells, an effect that was abrogated by HIF inhibition. Our results delineate an HIF-dependent transcriptional mechanism contributing to TNBC progression and suggest that combining chemotherapy with an HIF inhibitor may prevent countertherapeutic induction of proteins that mediate evasion of innate and adaptive antitumor immunity.

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19:40

Could Goldman Sachs report be exposing Pharmas real end game of drug dependency vs. curing disease? "IndyWatch Feed Health"

World Mercury Project (WMP) Note: This important article exposes how Goldman-Sachs looks at the business model of cure vs. no cure for diseases. The report asks the question: Is curing patients a sustainable business model? WMP is working to change this model. By the World Mercury Project Team Together, the U.S. government and American families are spending billions on medications, therapy, insurance,

19:21

Join the 7th Annual Food Revolution Summit- FREE "IndyWatch Feed Health"

You all know me: I love good, healthy, whole foods. LOVE. So I was absolutely thrilled when the team at the Food Revolution Summit asked me to invite you all to join 300,000+ other healthy food lovers for this totally FREE online event, beginning April 28th and going thru May 6th. When you sign up, youll get the latest cutting-edge insights

19:15

Houston Council to make a decision on fluoride "IndyWatch Feed Health"

Members of the Houston City Council heard input Monday during a hearing and later at their regular meeting on fluoridation.

The six-member council could decide to continue the 16-year-old practice, opt to end it or place the issue on a ballot. Two years ago, the council decided not to end it.

The most recent debate brought two national organizations to the Texas County seat  one against and another that supports it. Both sides spoke about 10 minutes each at the council meeting.

Dr. Paul Connett, a retired professor of chemistry and current director of the Fluoride Action Network, said the practice, which extends over generations, is unsafe, that children are being overexposed and forcing people to swallow fluoride made no sense. Additionally, he said damage can occur to teeth, bones and the brain, which is supported by study. He urged the council to support a more concentrated effort on education to fight tooth decay, obesity and chronic diseases, such as diabetes.

Johnny Johnson Jr., president of the American Fluoridation Society, disputed Connetts assertions and studies cited. He said across the country, adding fluoride had greatly reduced cavities and introduced studies he said were conducted at the highest standard including a finding just released that found no damage with even higher doses.

Johnson said public hearings have played out across the country over years, calling it a waste of time and energy, adding it is safe, effective and not hurting anyone.

The council meets next May 7.

*Original article online at https://www.houstonherald.com/council-to-make-a-decision-on-fluoride/article_fe29fe20-42a0-11e8-8d5d-db8e40c45261.html

19:11

Radiation-induces increased tumor cell aggressiveness of tumors of the glioblastomas. "IndyWatch Feed Health"

PMID:  Bull Cancer. 2014 Sep ;101(9):876-80. PMID: 25296414 Abstract Title:  [Radiation-induces increased tumor cell aggressiveness of tumors of the glioblastomas?]. Abstract:  Glioblastoma multiform is the most common and aggressive brain tumor with a worse prognostic. Ionizing radiation is a cornerstone in the treatment of glioblastome with chemo-radiation association being the actual standard. As a paradoxal effect, it has been suggested that radiotherapy could have a deleterious effect on local recurrence of cancer. In vivo studies have studied the effect of radiotherapy on biological modification and pathogenous effect of cancer cells. It seems that ionizing radiations with photon could activate oncogenic pathways in glioblastoma cell lines. We realized a review of the literature of photon-enhanced effect on invasion and migration of glioblastoma cells by radiotherapy.

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19:11

Houston council hears opinions on fluoridation "IndyWatch Feed Health"

It had all the trappings of a debate on a national stage: The countrys foremost critic of fluoridation and representatives of the national organization that promotes its use with a local medical community that has seen its benefits.

And it all happened in Houston, Mo., on a Monday night with the Houston City Council looking on as it found itself reliving a decision made 16 years ago to add fluoride to the water supply to improve dental health in the community. Houston is among about 75 percent of the countrys population now covered. Cabool also is included after generations of Cartwrights  the towns early dentists  promoted it.  Supporters say the benefits are undeniable. Critics say it is a health danger.

Houstons city government says the discussion was sparked by questions raised by George Sholtz, an Upton resident and a principal in a radio station whose airwaves cover Texas County and other regions. Sholtz, who frequently attends council meetings, raised questions about fluoridation at an earlier meeting and in writing. The council called for a public hearing and asked questions.

What resulted was a visit organized by opponents, including Sholtz and Marie Lasater of Licking, from Dr. Paul Connett, who operates an anti-fluoridation group, Fluoride Action Network.  That led the president of the American Fluoridation Society, Dr. Jonny Johnson Jr., and a colleague, Steve  Slott,  to arrive to provide an alternative view in an exchange at the Houston Storm Shelter and later at city hall, the venue for that early hearing in 2002 that filled the towns city hall.

The one-hour hearing allowed anyone to give a three-minute comment to the council. Later, the principals in the debate each had time to address the council at Houston City Hall during its regular meeting.

Heres what was said at the shelter  with City Administrator Tona Bowen at the time clock as the speakers rose for three minutes:

Members of the Hous...

19:09

Bloomberg: Drug made from cannabis plant gets backing from FDA "IndyWatch Feed Health"

U.K. company GW Pharmaceuticals Plc has created the first drug derived from the marijuana plant that might soon be approved in the U.S. Created with plants bred to have high cannabidiol, or CBD, content, the medication is a purified chemical made into a strawberry-flavored oral solution. GW Pharma hopes to market the medication under the name Epidiolex. The

19:07

Arctii Fructus and arctigenin are potential therapeutic agents against allergic inflammatory diseases. "IndyWatch Feed Health"

PMID:  J Agric Food Chem. 2017 Nov 1 ;65(43):9443-9452. Epub 2017 Oct 17. PMID: 28976750 Abstract Title:  Inhibition of Mast Cell-Mediated Allergic Responses by Arctii Fructus Extracts and Its Main Compound Arctigenin. Abstract:  The Arctium lappa seeds (Arctii Fructus) and its major active compound, arctigenin (ARC), are known to have anticancer, antiobesity, antiosteoporosis, and anti-inflammatory activities. However, the effect of Arctii Fructus and ARC on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, we attempted to investigate the antiallergic activity of Arctii Fructus and ARC on mast cells and experimental mouse models. Arctii Fructus water extract (AFW) or ethanol extract (AFE) and ARC reduced the production of histamine and pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-8, and TNF- in mast cells. AFW, AFE, and ARC inhibited phosphorylation of MAPKs and NF-B in activated mast cells. Moreover, IgE-mediated passive cutaneous anaphylaxis and compound 48/80-induced anaphylactic shock were suppressed by AFW, AFE, and ARC administration. Theseresults suggest that Arctii Fructus and ARC are potential therapeutic agents against allergic inflammatory diseases.

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18:56

Experimental study of the anti-tumour activity and pharmacokinetics of arctigenin and its valine ester derivative. "IndyWatch Feed Health"

PMID:  Sci Rep. 2018 Feb 19 ;8(1):3307. Epub 2018 Feb 19. PMID: 29459629 Abstract Title:  Experimental study of the anti-tumour activity and pharmacokinetics of arctigenin and its valine ester derivative. Abstract:  Arctigenin (ARG) is a functional active component that has important physiological and pharmacological activities. The anti-tumour and anti-inflammatory activities of ARG show good potential for application and development, but this material has the defect of low water solubility. In this experiment, the valine derivative of ARG (ARG-V) was designed and synthesized to overcome this disadvantage. The ARG amino acid, EDCI and DMAP were raw materials in the addition reaction, with a molar ratio of 1:2:2:0.5. The yield of ARG-V was up to 80%. ARG-V has strong anti-tumour activity in vivo and in vitro. The inhibitory rate of ARG-V was 69.2%, with less damage to the immune organs and different degrees of increased serum cytotoxicity. Moreover, the pharmacokinetics of ARG following oral administration and ARG-V following oral administration in rats were also studied. The Cand AUC values of ARG-V showed significant differences compared to ARG. The relative bioavailabilities of three doses of ARG-V compared to ARG were 664.7%, 741.5% and 812.9%. These pharmacokinetic results may be useful for further studies of the bioactive mechanism of ARG and provide a theoretical basic for clinical use.

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18:52

Does sugar make you sad? New science suggests so "IndyWatch Feed Health"

 

sugar depression

By Anika Knppel, UCL

The thought of a cupcake, skillfully frosted with fluffy vanilla icing, may put a smile on your face, but research suggests that, in the long term, a sweet tooth may turn that smile into a frown but not for the reasons you think. In a new study, published in Scientific Reports, my colleagues and I found a link between a diet high in sugar and common mental disorders.

The World Health Organisation recommends that people reduce their daily intake of added sugars (that is, all sugar, excluding the sugar that is naturally found in fruit, vegetables and milk) to less than 5% of their total energy intake. However, people in the UK consume double in the US, triple that amount of sugar. Three-quarters of these added sugars come from sweet food and beverages, such as cakes and soft drinks. The rest come from other processed foods, such as ketchup.

At the same time, one in six people worldwide suffers from a common mental disorder, such as a mood or anxiety disorder. Could there be a link between high sugar consumption and common mental disorders?

Earlier research, published in 2002, exa...

18:38

Guardian: Scientists accidentally create mutant enzyme that eats plastic bottles "IndyWatch Feed Health"

An accidental discovery is showing promise in our fight against the plastic that is taking over and polluting our world. In 2016, a bacterium that had naturally evolved to eat plastic was discovered at a dump in Japan and scientists have now revealed the detailed structure of the crucial enzyme produced by the bug. The international

18:06

This study has identified a new mechanism of action of arctigenin against liver cancer growth. "IndyWatch Feed Health"

PMID:  Front Pharmacol. 2018 ;9:268. Epub 2018 Mar 27. PMID: 29636686 Abstract Title:  Arctigenin Inhibits Liver Cancer Tumorigenesis by Inhibiting Gankyrin Expression via C/EBP and PPAR. Abstract:  Burdock () is a popular vegetable in China and Japan that is consumed for its general health benefits. The principal active component of burdock is arctigenin, which shows a range of bioactivitiesand. Here, we investigated the potential anti-tumor effects of arctigenin using two human hepatocellular carcinoma (HCC) cell lines, HepG2 and Hep3B, and sought to elucidate its potential mechanisms of action. Our results showed that arctigenin treatment inhibited cell growth in both HepG2 and Hep3B cell lines (ICof 4.74 nM for HepG2 cells, and of 59.27 nM for Hep3B cells). In addition, migration, invasion, and colony formation by HepG2 cells were significantly inhibited by arctigenin. By contrast, treatment of Hep3B cells with arctigenin did not alter these parameters. Arctigenin also significantly reduced the levels of gankyrin mRNA and protein in HepG2 cells, but not in Hep3B cells. A luciferase assay indicated that arctigenin targeted the -450 to -400 region of the gankyrin promoter. This region is also the potential binding site for both C/EBP and PPAR, as predicted and confirmed by an online software analysis and ChIP assay. Additionally, a co-immunoprecipitation (Co-IP) assay showed that binding between C/EBP and PPAR was increased in the presence of arctigenin. However, arctigenin did not increase the expression of C/EBP orPPAR protein. A binding screening assay and liquid chromatography-mass spectrometry (LC-MS) were performed to identify the mechanisms by which arctigenin regulates gankyrin expression. The results suggested that arctigenin could directly increase C/EBP binding to the gankyrin promoter (-432 to -422 region), but did not affect PPAR binding. Expression of gankyrin,, andwere analyzed in tumor tissues of patients using real-time PCR. Bothandshowed negative correlations with gankyrin. In tumor-bearing mice, arctigenin had a significant inhibitory effect on HCC growth. In conclusion, our results suggested that arctigenin could inhibit liver cancer growth by directly recruiting C/EBP to the gankyrin promoter. PPAR subsequently bound to C/EBP, and both had a negative regulatory effect on gankyrin expression. This study has identified a new mechanism of action of arctigenin against liver cancer growth.

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17:42

Gmail should be banned, please stop using it "IndyWatch Feed Health"

By Dr. Mercola Google and Facebook are two of the largest and clearest monopolies in the world, and between them, the harvesting of your personal information goes far beyond what most people realize was even possible. I have recently removed Google Search from this website and replaced with a search engine without the privacy concerns,

17:41

A. lappa could protect the liver cells from carbon tetrachloride or acetaminophen-induced liver damages. "IndyWatch Feed Health"

PMID:  Am J Chin Med. 2000 ;28(2):163-73. PMID: 10999435 Abstract Title:  Hepatoprotective effects of Arctium lappa on carbon tetrachloride- and acetaminophen-induced liver damage. Abstract:  The root of Arctium lappa Linne (A. lappa) (Compositae), a perennial herb, has been cultivated for a long time as a popular vegetable. In order to investigate the hepatoprotective effects of A. lappa, male ICR mice were injected with carbon tetrachloride (CCl4, 32 microl/kg, i.p.) or acetaminophen (600 mg/kg, i.p.). A. lappa suppressed the SGOT and SGPT elevations induced by CCl4 or acetaminophen in a dose-dependent manner and alleviated the severity of liver damage based on histopathological observations. In an attempt to elucidate the possible mechanism(s) of this hepatoprotective effect, glutathione (GSH), cytochrome P-450 (P-450) and malondialdehyde (MDA) contents were studied. A. lappa reversed the decrease in GSH and P-450 induced by CCl4 and acetaminophen. It was also found that A. lappa decreased the malondialdehyde (MDA) content in CCl4 or acetaminophen-intoxicated mice. From these results, it was suggested that A. lappa could protect the liver cells from CCl4 or acetaminophen-induced liver damages, perhaps by its antioxidative effect on hepatocytes, hence eliminating the deleterious effects of toxic metabolites from CCl4 or acetaminophen.

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17:19

Pruritus after intrathecal morphine for cesarean delivery: incidence, severity and its relation to serum serotonin level. "IndyWatch Feed Health"

PMID:  Int J Obstet Anesth. 2018 Feb 16. Epub 2018 Feb 16. PMID: 29544720 Abstract Title:  Pruritus after intrathecal morphine for cesarean delivery: incidence, severity and its relation to serum serotonin level. Abstract:  BACKGROUND: Pruritus is the most common side effect of intrathecal morphine, especially in parturients. The exact mechanism is not clear and many possible mechanisms have been suggested. Among these is the activation of the 5-hydroxytryptamine sub-type-3 receptors by intrathecal morphine.METHODS: Forty parturients who underwent elective cesarean delivery under spinal anesthesia were divided into two groups of 20 each in this prospective, randomized study. Both groups received an intrathecal injection of 0.5% (2-3mL) hyperbaric bupivacaine in addition to 100g of morphine in group 1 (M100) and 200g of morphine in group 2 (M200). Two blood samples were taken from each patient for serotonin estimation, preoperatively and four hours later. Postoperatively, all patients were assessed for pruritus (incidence and severity), pain (visual analog pain scale), first request for analgesia, and total analgesic dose required within 24hours.RESULTS: The serum serotonin level increased significantly postoperatively, by 283% versus 556% (P

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16:55

These studies indicate the morphine can have a deleterious effect on postoperative pain. "IndyWatch Feed Health"

PMID:  Anesth Analg. 2018 Mar 27. Epub 2018 Mar 27. PMID: 29596097 Abstract Title:  Repeated Morphine Prolongs Postoperative Pain in Male Rats. Abstract:  BACKGROUND: Opioids are effective postoperative analgesics. Disturbingly, we have previously reported that opioids such as morphine can worsen inflammatory pain and peripheral and central neuropathic pain. These deleterious effects are mediated by immune mediators that promote neuronal hyperexcitability in the spinal dorsal horn. Herein, we tested whether perioperative morphine could similarly prolong postoperative pain in male rats.METHODS: Rats were treated with morphine for 7 days, beginning immediately after laparotomy, while the morphine was tapered in a second group. Expression of genes for inflammatory mediators was quantified in the spinal dorsal horn. In the final experiment, morphine was administered before laparotomy for 7 days.RESULTS: We found that morphine treatment after laparotomy extended postoperative pain by more than 3 weeks (time treatment: P

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14:16

Is there evidence that our meat-sweet diets play a cause-and-effect role in dementia? "IndyWatch Feed Health"

In the video below, Dr. Greger discusses what the science says about the role diet plays in our brain health. This quick video is a must for anyone who is aging or dealing with a relative in the beginning stages of dementia or Alzheimers Disease.  RELATED STORY: This vegetable puts the brakes on beta-amyloid and Alzheimers

Tuesday, 17 April

19:47

AP: #MeToo has little impact on medical world "IndyWatch Feed Health"

According to a recent AP investigation, the world of medicine is often far more forgiving about sexual misconduct than it should be. And certainly more forgiving than weve seen in pop culture over the last few months. If a doctor is found to have committed some type of misconduct, when and IF they are disciplined,

18:06

Sign up for the FREE Chronic Lyme Disease Summit "IndyWatch Feed Health"

Im proud to be participating in the 3rd Chronic Lyme Disease Summit, a free, online summit beginning April 30th. RELATED STORY: Dr. Klinghardts Treatment of Lyme Disease >>>>>>>>>>>>Click here to sign up for FREE!<<<<<<<<<<<<<< After battling Lyme Disease for years, and finally having freedom from it, Im passionate about people finding that same thing for

16:54

Millions will soon die from these infections, unless we stop this nonsense "IndyWatch Feed Health"

By Dr. Mercola According to the largest review of the drug resistance problem to date, by 2050 the annual global death toll from antibiotic-resistant disease will reach 10 million. At present, an estimated 23,000 Americans die each year from drug-resistant infections, and the death toll will continue to rise until or unless the underlying causes are

16:52

AP: Baboons work together to escape research facility, but are apprehended "IndyWatch Feed Health"

(Editors Note: We love animals and we absolutely hate animal testing. Period. So it is with heavy hearts that we share this story with you.) Over the weekend, four baboons worked together to ESCAPE from the Southwest National Primate Reseach Center in San Antonio, Texas, one of seven federally supported National Primate Research Centers. However, they

14:36

5 Steps to a More Active Life with BetterMe Fitness App "IndyWatch Feed Health"


The article below is a sponsored review for the BetterMe Fitness App

Were on a quest to find the fitness app an app with excellent reviews and excellent features that is actually good for you. Well, BetterMe reviews suggest that everything is okay in the customer satisfaction department, but will we be as excited about this app when we try it out?

Why were reviewing BetterMe fitness app

Today, its so simple to download an app, use it for a bit and either delete and forget about it, or find out that you really like this tiny little helper and recommend it to your friends. The wellness and fitness app section is overflowing with options both on GooglePlay and AppStore, so the competition is kind of tough. What makes a certain fitness app stand out?

The BetterMe app is relatively new on the market, but it already tops the app charts and has thousands of mostly positive reviews. BetterMe Facebook community seems to be thriving as well, and they have their own site, BetterMe Guru, dedicated to health and wellness. So the BetterMe brand looks intriguing enough!

Exploring BetterMe

Both iOS and Android device owners can use the app. The developers strongly advise to download it only through AppStore or GooglePlay, to avoid possible scamming attempts.

Youll need to enter your email, or register through Facebook, in order to set up an account with BetterMe.

The app makes use of some of your personal data you enter yourself, such as weight, age, height, target weight, your level of physical training (a newbie,...

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