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Friday, 24 November


Your Earwax Can Give You Important Clues about Your Health "IndyWatch Feed Health"

For the most part, we dont spend a lot of time thinking about the inside of our ears, apart from a very general are they clean?. Perhaps we should be giving them more thought because the color of our earwax can say a lot about our general health, and it can give us valuable clues... View Article

The post Your Earwax Can Give You Important Clues about Your Health appeared first on Healthy Holistic Living.


Pinterest Censoring Anti-Vaccine Doctors and Pins Related to Vaccine Rights "IndyWatch Feed Health"

Pinterest Vaccines Censored

by Brian Shilhavy
Editor, Health Impact News

The popular image-sharing social media website Pinterest is blocking pins that provide safety information about vaccines, or question whether or not legislation should be passed to mandate vaccines.

When Health Impact News noticed that some of their pins were no longer showing, we contacted Pinterest to find out why.

Someone named Tina from Pinterest Help emailed this to Health Impact News:

One or more of your Pins about vaccines has been highlighted as containing medical misinformation. Per our policy, this content will remain available to you, but it will be hidden from circulation on Pinterest as it contains claims that are considered to be misleading or inaccurate by the medical community.

We dont know which pins they actually blocked (we have thousands of them on their site), but a pro Big Pharma company printed a commentary last year about an article published in the pro-vaccine journal Vaccine that criticized Pinterest for allow pins that contradict Big Pharmas pro-vaccine extremist position, or questioned parental rights in regards to vaccine choice.

In their commentary on the Journal article On pins and needles: How vaccines are portrayed on Pinterest they lamented:

Guidry and her colleagues collected 800 pins and analyzed them to determine whether they are pro- or anti-vaccination.

The results revealed that 75 percent of all vaccine-related pins were negative.

Rather than using social media as a tool to understand the publics sentiment and experience with vaccines (which of course includes doctors and other medical professionals) and respect those views, this information was used as fuel to pressure lawmakers into passing laws to punish those who do not believ...


8 Symptoms of Meningitis That Every Parent Should Know About "IndyWatch Feed Health"

This article is shared with permission from our friends at Medical News Today. Bacterial meningitis is the most serious type of meningitis. It can lead to death or permanent disability. It is a medical emergency. Meningitis affects the meninges, the membranes that surround the brain and spinal cord and protect the central nervous system (CNS), together with... View Article

The post 8 Symptoms of Meningitis That Every Parent Should Know About appeared first on Healthy Holistic Living.


The treatment appeared to prevent some of the changes in the microbiota associated with penicillin use. "IndyWatch Feed Health"

PMID:  PLoS One. 2016 ;11(4):e0154012. Epub 2016 Apr 25. PMID: 27111772 Abstract Title:  Lactobacillus rhamnosus GG Intake Modifies Preschool Children's Intestinal Microbiota, Alleviates Penicillin-Associated Changes, and Reduces Antibiotic Use. Abstract:  UNLABELLED: Antibiotic use is considered among the most severe causes of disturbance to children's developing intestinal microbiota, and frequently causes adverse gastrointestinal effects ranging from mild and transient diarrhoea to life-threatening infections. Probiotics are commonly advocated to help in preventing antibiotic-associated gastrointestinal symptoms. However, it is currently unknown whether probiotics alleviate the antibiotic-associated changes in children's microbiota. Furthermore, it is not known how long-term probiotic consumption influences the developing microbiota of children. We analysed the influence of long-term Lactobacillus rhamnosus GG intake on preschool children's antibiotic use, and antibiotic-associated gastrointestinal complaints in a double blind, randomized placebo-controlled trial with 231 children aged 2-7. In addition, we analysed the effect of L. rhanmosus GG on the intestinal microbiota in a subset of 88 children. The results show that long-term L. rhamnosus GG supplementation has an influence on the composition of the intestinal microbiota in children, causing an increase in the abundance of Prevotella, Lactococcus, and Ruminococcus, and a decrease in Escherichia. The treatment appeared to prevent some of the changes in the microbiota associated with penicillin use, but not those associated with macrolide use. The treatment, however, did reduce the frequency of gastrointestinal complaints after a macrolide course. Finally, the treatment appeared to prevent certain bacterial infections for up to 3 years after the trial, as indicated by reduced antibiotic use.TRIAL REGISTRATION: NCT01014676.

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Are We Headed For Near-Term Human Extinction? "IndyWatch Feed Health"

earth warming-614722536Source: Now Toronto Recent studies suggest it is irresponsible to rule out the possibility after last week's "warning to humanity" from more than 15,000 climate change scientists Shifts in climate can be exponential, abrupt and massive due to feedbacks, which can amplify and diminish the effects of global warming. A warning to humanity raising the spectre of potentially


Certain probiotics could potentially prevent postpartum uterine diseases in dairy cows, ultimately reducing the use of antibiotics. "IndyWatch Feed Health"

PMID:  Inflammation. 2016 Aug ;39(4):1483-94. PMID: 27236308 Abstract Title:  Lactobacillus rhamnosus GR-1 Limits Escherichia coli-Induced Inflammatory Responses via Attenuating MyD88-Dependent and MyD88-Independent Pathway Activation in Bovine Endometrial Epithelial Cells. Abstract:  Intrauterine Escherichia coli infection after calving reduces fertility and causes major economic losses in the dairy industry. We investigated the protective effect of the probiotic Lactobacillus rhamnosus GR-1 on E. coli-induced cell damage and inflammation in primary bovine endometrial epithelial cells (BEECs). L. rhamnosus GR-1 reduced ultrastructure alterations and the percentage of BEECs apoptosis after E. coli challenge. Increased messenger RNA (mRNA) expression of immune response indicators, including pattern recognition receptors (toll-like receptor [TLR]2, TLR4, nucleotide-binding oligomerization domain [NOD]1, and NOD2), inflammasome proteins (NOD-like receptor family member pyrin domain-containing protein 3, apoptosis-associated speck-like protein, and caspase-1), TLR4 downstream adaptor molecules (myeloid differentiation antigen 88 [MyD88], toll-like receptor adaptor molecule 2 [TICAM2]), nuclear transcription factor kB (NF-kB), and the inflammatory cytokines tumor necrosis factor (TNF)-, interleukin (IL)-1, IL-6, IL-8, IL-10, IL-18, and interferon (IFN)-, was observed following E. coli challenge. However, these increases were attenuated by L. rhamnosus GR-1 pretreatment. Our data indicate that L. rhamnosus GR-1 ameliorates the E. coli-induced disruption of cellular ultrastructure, subsequently reducing the percentage of BEECs apoptosis and limiting inflammatory responses, partly via attenuation of MyD88-dependent and MyD88-independent pathway activation. Certain probiotics could potentially prevent postpartum uterine diseases in dairy cows, ultimately reducing the useof antibiotics.

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The Many Benefits of Coconut Oil For Pets "IndyWatch Feed Health"

Coconut oil has become well known for being rich in health benefits for people, but what people do not know is that it is good for your pets as well! Incorporating organic coconut oil into your cats and dogs lives both topically and internally will undoubtedly lead to dramatic improvements in their overall health! Coconut... View Article

The post The Many Benefits of Coconut Oil For Pets appeared first on Healthy Holistic Living.


How to Make Chai Tea to Reduce Inflammation, Strengthen Immunity, and Improve Digestion "IndyWatch Feed Health"

This article is shared with permission from our friends at Complete Health and Happiness. Suffering from digestion problems or coming down with a cold? Chai tea will help you strengthen your immune system and improve digestion. Chai tea is a powerful antioxidant that helps destroy free radicals that are thought to be one of the causes... View Article

The post How to Make Chai Tea to Reduce Inflammation, Strengthen Immunity, and Improve Digestion appeared first on Healthy Holistic Living.


Toxic buildup leads to weight gain, belly fat, and other health problems. Try This Simple Detox Drink "IndyWatch Feed Health"

Article originally published on, republished with permission.  Do you suffer from excess weight, joint pain, headaches, acne, food allergies, depression, insomnia, fatigue? If so, it could be that your body is out of balance and suffering from toxic overload. Your weight gain and belly fat can be linked to toxins in your liver. The liver has two... View Article

The post Toxic buildup leads to weight gain, belly fat, and other health problems. Try This Simple Detox Drink appeared first on Healthy Holistic Living.


Herpes Vaccine Researcher Illegally Injected People With Modified Virus in Backalley Trials "IndyWatch Feed Health"

By Heather CallaghanEditor

Microbiologist William Halford of South Illinois University conducted illegal live virus herpes vaccine trials on participants in hotels without written, informed consent or oversight.

In the months spanning 2013 in Illinois and again in 2016 offshore, he injected his own created, live herpes virus injection into them and may have given two or more of the human subjects, a form genital herpes. He conducted his own brand of experiment without any outside accountability not from doctors, nurses or medical staff, and without notifying any U.S. authorities.

Halford escaped all forms of Earthly accountability when he died of cancer this past June. But before he died, RT reports that he

administered his experimental shots to at least eight herpes patients on four different occasions in the summer and fall of 2013. The volunteers were injected with a virus he had created, according to emails from seven participants and interviews with one participant.

In multiple email exchanges between Halford and the participants, seen by Kaiser...


East Coast Cannabis Conference Nov. 25-26 "IndyWatch Feed Health"

Follow Us!Share This!Still time to register for the East Coast Cannabis Conference! Speakers include our ED Mary Lynn Mathre and many more. More information and registration at Follow Us!Share This!


Action Alerts, #GivingTuesday, Issue 1000, Remembering Rep. Hinchey "IndyWatch Feed Health"

I hope that those of you who mark Thanksgiving had a good holiday.

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Support Patients Out of Time While You Shop! "IndyWatch Feed Health"

Follow Us!Share This!Getting ready to make your holiday purchases online this year? Shop for everyone on your gift list at and Amazon will donate a percentage of your purchase to Patients Out of Time! Follow Us!Share This!


Factory Shut Down, Police Investigating as Human Waste Found in Coke Cans "IndyWatch Feed Health"

Despite Coca-Colas best marketing efforts, virtually everyone already knows the world-wide popular soft drink isnt healthy. Whether its the high sugar count or aspartame, or the fact that it can act as a pretty effective household cleaner, its pretty obvious that its bad for your health. Still, somehow the corporate giant is worth over $87 billion... View Article

The post Factory Shut Down, Police Investigating as Human Waste Found in Coke Cans appeared first on Healthy Holistic Living.


A mixture containing Lactobacillus GG and micronutrients may reduce the incidence of nosocomial infections. "IndyWatch Feed Health"

PMID:  Aliment Pharmacol Ther. 2016 Sep ;44(6):568-75. Epub 2016 Jul 28. PMID: 27464469 Abstract Title:  Randomised clinical trial: a Lactobacillus GG and micronutrient-containing mixture is effective in reducing nosocomial infections in children, vs. placebo. Abstract:  BACKGROUND: Nosocomial infections are a major public health issue and preventative strategies using probiotics and micronutrients are being evaluated.AIM: To investigate the efficacy of a mixture of Lactobacillus GG and micronutrients in preventing nosocomial infections in children.METHODS: A randomised, double-blind, placebo-controlled trial was conducted in hospitalised children. Children (6 months to 5 years of age) received Lactobacillus GG (6 10(9) CFU/day) together with vitamins B and C and zinc or placebo, for 15 days, starting on the first day of hospitalisation. The incidence of gastrointestinal and respiratory nosocomial infections after discharge was determined by follow-up telephone call at 7 days. After 3 months, another telephone call estimated the incidence of further infections during follow-up.RESULTS: Ninety children completed the follow-up. Of 19/90 children with a nosocomial infection (20%), 4/45 children (9%) were in the treatment group and 15/45 (33%) in the placebo group (P = 0.016). Specifically, 2/45 (4%) children in the treatment group vs. 11/45 (24%) children in the placebo group (P = 0.007) presented with diarrhoea. The duration of hospitalisation was significantly shorter in the treatment group (3.9 days 1.7 vs. 4.9 1.2; P = 0.003). At the follow-up, a total of 11/45 (24.4%) children in the treatment group had at least one episode of infection compared to 22/45 (48.9%) in the placebo group (P = 0.016).CONCLUSION: A mixture containing Lactobacillus GG and micronutrients may reduce the incidence of nosocomial infections, supporting the hypothesis that this may represent a valid strategy to prevent nosocomial infections.

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ALERT: Medical Marijuana Is Under Threat -- Tell Congress to Act! "IndyWatch Feed Health"

For the first time in years, there's a chance that the federal budget law which has protected medical marijuana won't get reauthorized.

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Psychiatry: The Brain is a Malignant Tumor! "IndyWatch Feed Health"

My introduction to organized psychiatry came when, as a college freshman, I joined a Harvard volunteer program at the local state mental hospital. I spent hundreds of hours on the wards and eventually directed the volunteer program.

Among the astonishing educational experiences I had, one of the most stunning was my conversation with the psychiatrist running the insulin shock room in which the staff injected the hapless inmates with overdoses of insulin until their brain began to die, sending them into convulsions, unconsciousness and then a deep coma. Sometimes they writhed, sometimes they lay still like the dead that they were becoming, until saved by doses of sugar.

I asked the psychiatrist, How does insulin coma help?

He replied with certainty, It kills bad brain cells.

While still a skeptical college freshman and sophomore, I began reading on my own about what the institution of psychiatry routinely inflicted on its patients. There was insulin shockwhich undeniably killed brain cells. Tissue samples showed the dead and dying cell. And electroshock that wrecks the brain and kills the neurons of hundreds of thousands in America today, as well as the less common final resort, sending them off for lobotomies to have portions of their normal brain tissue cut or burned out. I struggled in my own mind as a young college student to understand what could motivate anyone to inflict such damaging assaults on the brains of other people.

Much more recently, in fact within the last year, I have returned to studying the origins of the first blockbuster miracle drugThorazine (chlorpromazine). I have already put up some of the original research papers from the early 1950s written by the pioneers Delay and Deniker on my free Antipsychotic Resource Center ( After experimenting with the new drugs for about two years, and watching Thorazine go viral around the world, the Frenchmen realized that the drug was behaving like an epidemic encephalitis agent. They realized they had discovered a neurotoxin!

Delay and Denikers promotional work had already led to millions of patients being overwhelmed by the new neurotoxins, inevitable suffering from all kinds of dreadful neurological and physical reactions. By 1957, they knew in detail how their drugs mimicked a well-known neurotoxic epidemic called lethargic encephalitis.

So what did the two doctors do? Did they write and phone their colleagues to say, Wait! Weve made a dreadful mistake. We are spreading neurotoxins across the face of the earth.

No, they didnt. Instead, they conta...


Castor Oil Is Great For Thickening Helping Regrow Hair, Eyelashes And Eyebrows "IndyWatch Feed Health"

Castor oil is often overlooked for its benefits for the skin and hair because of its extremely thick and sticky consistency.  However, if youre looking for a cheap, natural remedy for several common skin and hair complaints, then castor oil is definitely worth your time. Castor Oil For Thickening Hair, Eyelashes and Eyebrows I first... View Article

The post Castor Oil Is Great For Thickening Helping Regrow Hair, Eyelashes And Eyebrows appeared first on Healthy Holistic Living.


6 Warning Signs of Breast Cancer You Shouldnt Ignore "IndyWatch Feed Health"

This article is shared with permission from our friends at Living Traditionally. Breast cancer is the number one cancer that kills women. While age, diet, physical activity, and lifestyle play an important role in the development of breast cancer, an estimated 15 percent of women who have breast cancer already have a genetic susceptibility. Breast cancer is a malignancy... View Article

The post 6 Warning Signs of Breast Cancer You Shouldnt Ignore appeared first on Healthy Holistic Living.


This Syrup Will Stop a Cough Dead in its Tracks Ginger Thyme Cough Syrup "IndyWatch Feed Health"

Thyme is a powerful and effective disinfectant and can be used both externally (as a wash) and internally to help fight off infection. One of the best herbal cold remedies, its often used to help ward off colds and as a rinse to treat a sore throat and oral infections. It also makes a fine... View Article

The post This Syrup Will Stop a Cough Dead in its Tracks Ginger Thyme Cough Syrup appeared first on Healthy Holistic Living.


How To Instantly Stop A Migraine With Salt "IndyWatch Feed Health"

This article is shared with permission from our friends at Living Traditionally. Migraine sufferers are often anxious to rid themselves of the terrible pain characterizing this condition. A migraine is nothing to laugh at; a really bad migraine can pretty much cripple you and take you down for the rest of your day. Whats worse, there... View Article

The post How To Instantly Stop A Migraine With Salt appeared first on Healthy Holistic Living.


Even Science Agrees: Once a Cheater, Always a Cheater "IndyWatch Feed Health"

Relationships are tough. Its estimated that somewhere between 30 and 60% of all married individuals are unfaithful at one point in their partnership. And while there might be all kinds of reasons or circumstances unique to every couple that push one partner to cheating for the first time, psychologists have found just a couple of... View Article

The post Even Science Agrees: Once a Cheater, Always a Cheater appeared first on Healthy Holistic Living.


G.E.R.D. (Severe Acid Reflux) Off The Grid "IndyWatch Feed Health"

Acid Reflux Off The Grid In this high-stress world, you probably know someone who suffers from G.E.R.D. (Gastroesophageal Reflux Disease). Gastro- refers to your stomach; -esophageal refers to the tube that runs from it to your throat. Acid reflux is essentially acid that escapes the stomach and can go all the way up to your throat. G.E.R.D. is a severe form of acid reflux that can ruin a persons quality of life. Normally, an area called the lower esophageal sphincter

[... Continue Reading]


World Mercury Project Leads the Way ACTION ALERT "IndyWatch Feed Health"

by Elissa Meininger Health Policy Analyst In earlier articles here on The Bolen Report, we have highlighted and praised the work of Robert F. Kennedy, Jr. in his courageous and relentless drilling down to the bottom of Americas corrupt vaccine policy and law swamp. His appointment by President Trump to do this work was Continue reading World Mercury Project Leads the Way ACTION ALERT

The post World Mercury Project Leads the Way ACTION ALERT appeared first on BolenReport.


If You Fly Commercial Airlines Be Forewarned About Aerotoxic Syndrome "IndyWatch Feed Health"

By Catherine J. Frompovich

Whats Aerotoxic syndrome, and have you experienced it while a passenger in a modern jet airliner?

Many flight crews, regardless of the airline, experience serious debilitating health problems from toxic air in the cockpit and cabin. Passengers, too!

Coincidentally, I know of a person who just about every time she flies, she comes down with bronchitis, infected sinuses, sore throat and/or other respiratory problems. Somehow I dont think shes able to make the connection between toxic airplane air and her subsequent health distresses occurring within a day of flying.

This article deals with a former KLM pilot and medical doctor, Michel Mulder, who began an in-depth investigation in 2013 into Aerotoxic syndrome, which affects airline pilots, crews and passengers. Mulder contends contaminated air flows through the engine into the cockpit and cabin. Bleed-air is causing the problem. Neurologist Dr. Gerard Hegaman contends the industry no longer can ignore the symptoms associated with Aerotoxic syndrome.

Dr. Hegaman ascertained that one KLM pilot, Willem Felderhof, has a genetic sensitivity or DNA mutation, something that also happens withand affectsindividuals who are sensitive to toxic chemicals in vaccines, microwaves, Wi-Fi and...


This Mixture That Will Make Your Home Smell so WonderfulYour Neighbors Will Envy You "IndyWatch Feed Health"

As much as we all love the unique smells of herbs, spices, veggies, meats and more, sometimes those potent fragrances can get trapped inside the house for longer than wed like, and seep into the furniture or your clothes. Who else has had the experience of guests about to come over, and the entire place still... View Article

The post This Mixture That Will Make Your Home Smell so WonderfulYour Neighbors Will Envy You appeared first on Healthy Holistic Living.


Australia To Go After Anti-Vaccine Doctors For Making False Statements "IndyWatch Feed Health"

That Australian Minister of Health has announced that it will be lowering its tolerance level for doctors who decide that a child is not healthy enough to be vaccinated. Medical exemptions have risen in Australia...

The post Australia To Go After Anti-Vaccine Doctors For Making False Statements appeared first on Vaxxter.


Nobel Prize Winner Dr. Luc Montaigne Speaks About Vaccines and SIDS "IndyWatch Feed Health"

C'est la guerre. French Nobel Prize winner Dr. Luc Montaigne was criticized for his discussion of vaccine safety. In Europe, just as here in America, when you question vaccine safety or vaccine side effects, you are considered "alarmist." Mustn't allow...


Caught Our Notice: To know if someones been vaccinated, just asking isnt enough "IndyWatch Feed Health"

Title: Hepatitis B Virus Infection in Preconception Period Among Women of Reproductive Age in Rural China A Nationwide Study What Caught Our Attention: When researchers set out to study hepatitis B among women in rural China, and they wanted to know if the women had been vaccinated against the virus, they simply asked them. While []

The post Caught Our Notice: To know if someones been vaccinated, just asking isnt enough appeared first on Retraction Watch.


Italian Court Rejects Veneto Regions Vaccine Mandate Appeal "IndyWatch Feed Health"

ALL RIGHTS RESERVED Copyright ANSA NOTE: Vaccines have become an offer Italians can NOT refuse - without steep penalties. Disgrazia. Kim (ANSA) - Rome, November 22 - The Constitutional Court on Wednesday rejected the Veneto regional government's appeal against...


Inside Croatias Pioneering Mental Health Center "IndyWatch Feed Health"

From The Guardian: The oldest asylum in the Balkans has now been transformed into an unlocked mental health center. The patients have begun living in the community with in-home services and supports.

It is 10 years since Croatia signed the UNs Convention on the Rights of Persons with Disabilities but Osijek is the only one of Croatias 24 mental health institutions, which house a total of 6,700 people, implementing its spirit. We signed this with our fingers crossed behind our backs. The government still wants people locked up, locked away. People with disabilities, whether mental health or physical, have rights. There are four reasons why inclusion is better than exclusion, said Lamza. Its better for a person, its better for the community, its legal, its cheaper. He says the cost per person per month in an institution is $1,260 (950). In the community, even with the maximum 24-hour support, it is $1,020.'



The Link Between Poor Mental Health and Low Income "IndyWatch Feed Health"

From Metro: Poverty can have a dramatic effect on peoples mental and physical health, as it can impact diet, healthcare access, sleep, and socialization.

There are plenty of rightwing rent-a-gobs hired to spout the idea that people living in poverty should simply forgo luxuries like big televisions or certain foods. The problem here, though, is that although doing that might save a few pennies in the short term, it removes peoples sources of entertainment and comfort.

Those of us lucky enough to afford trips to the cinema or a bit of retail therapy here and there are never vilified for it. These things make life worth living, by giving us variety and happiness. Everybody deserves that sense of release.



Women With Endometriosis at Risk of Mental Health Issues "IndyWatch Feed Health"

From The Sun: According to a new study, one in ten women with the chronic condition endometriosis are at a greater risk of developing mental health problems. The pain caused by the condition is associated with higher levels of anxiety, depression, and other psychiatric disorders.



Don't Forget to Use Amazon Smile to Support Age of Autism "IndyWatch Feed Health"

Hi, Friends. Here's an easy way to support our work. Make a 1/2% donation to us through Amazon Smile each time you make a purchase. You simply designate us as your organization - and Amazon does the donating! Click here...


Probiotic Lactobacillus rhamnosus reduces organophosphate pesticide absorption and toxicity to Drosophila melanogaster. "IndyWatch Feed Health"

PMID:  Appl Environ Microbiol. 2016 Oct 15 ;82(20):6204-6213. Epub 2016 Sep 30. PMID: 27520820 Abstract Title:  Probiotic Lactobacillus rhamnosus Reduces Organophosphate Pesticide Absorption and Toxicity to Drosophila melanogaster. Abstract:  : Organophosphate pesticides used in agriculture can pose health risks to humans and wildlife. We hypothesized that dietary supplementation with Lactobacillus, a genus of commensal bacteria, would reduce absorption and toxicity of consumed organophosphate pesticides (parathion and chlorpyrifos [CP]). Several Lactobacillus species were screened for toleration of 100 ppm of CP or parathion in MRS broth based on 24-h growth curves. Certain Lactobacillus strains were unable to reach stationary-phase culture maxima and displayed an abnormal culture morphology in response to pesticide. Further characterization of commonly used, pesticide-tolerant and pesticide-susceptible, probiotic Lactobacillus rhamnosus strain GG (LGG) and L. rhamnosus strain GR-1 (LGR-1), respectively, revealed that both strains could significantly sequester organophosphate pesticides from solution after 24-h coincubations. This effect was independent of metabolic activity, as L. rhamnosus GG did not hydrolyze CP and no difference in organophosphate sequestration was observed between live and heat-killed strains. Furthermore, LGR-1 and LGG reduced the absorption of 100M parathion or CP in a Caco-2 Transwell model of the small intestine epithelium. To determine the effect of sequestration on acute toxicity, newly eclosed Drosophila melanogaster flies were exposed to food containing 10 M CP with or without supplementation with live LGG. Supplementation with LGGsimultaneously, but not with administration of CP 3 days prior (prophylactically), mitigated CP-induced mortality. In summary, the results suggest that L. rhamnosus may be useful for reducing toxic organophosphate pesticide exposure via passive binding. These findings could be transferable to clinical and livestock applications due to affordability and practical ability to supplement products with food-grade bacteria.IMPORTANCE: The consequences of environmental pesticide pollution due to widespread usage in agriculture and soil leaching are becoming a major societal concern. Although the long-term effects of low-dose pesticide exposure for humans and wildlife remain largely unknown, logic suggests that these chemicals are not aligned with ecosystem health. This observation is most strongly supported by the agricultural losses associated with honeybee population declines, known as colony collapse disorder, in which pesticide usage is a likely trigger. Lactobacilli are bacteria used as beneficial microorganisms in fermented foods and have shown potentials to sequester and degrade environmental toxins. This study demonstrated th...


Lectin-like molecules of Lactobacillus rhamnosus GG inhibit pathogenic Escherichia coli and Salmonella biofilm Formation. "IndyWatch Feed Health"

PMID:  PLoS One. 2016 ;11(8):e0161337. Epub 2016 Aug 18. PMID: 27537843 Abstract Title:  Lectin-Like Molecules of Lactobacillus rhamnosus GG Inhibit Pathogenic Escherichia coli and Salmonella Biofilm Formation. Abstract:  OBJECTIVES: Increased antibiotic resistance has catalyzed the research on new antibacterial molecules and alternative strategies, such as the application of beneficial bacteria. Since lectin molecules have unique sugar-recognizing capacities, and pathogens are often decorated with sugars that affect their survival and infectivity, we explored whether lectins from the probiotic strain Lactobacillus rhamnosus GG have antipathogenic properties.METHODS: The genome sequence of L. rhamnosus GG was screened for the presence of lectin-like proteins. Two genes, LGG_RS02780 and LGG_RS02750, encoding for polypeptides with an N-terminal conserved L-type lectin domain were detected and designated Llp1 (lectin-like protein 1) and Llp2. The capacity of Llp1 and Llp2 to inhibit biofilm formation of various pathogens was investigated. Sugar specificity was determined by Sepharose beads assays and glycan array screening.RESULTS: The isolated lectin domains of Llp1 and Llp2 possess pronounced inhibitory activity against biofilm formation by various pathogens, including clinical Salmonella species and uropathogenic E. coli, with Llp2 being more active than Llp1. In addition, sugar binding assays with Llp1 and Llp2 indicate specificity for complex glycans. Both proteins are also involved in the adhesion capacity of L. rhamnosus GG to gastrointestinal and vaginal epithelial cells.CONCLUSIONS: Lectins isolated from or expressed by beneficial lactobacilli could be considered promising bio-active ingredients for improved prophylaxis of urogenital and gastrointestinal infections.

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Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women. "IndyWatch Feed Health"

PMID:  Taiwan J Obstet Gynecol. 2016 Aug ;55(4):515-8. PMID: 27590374 Abstract Title:  Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial. Abstract:  OBJECTIVE: This study is to examine the effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 taken orally before bedtime on Group B Streptococcus (GBS)-positive pregnant women with respect to becoming GBS negative.MATERIALS AND METHODS: In total, 110 pregnant women at 35-37 weeks of gestation who were diagnosed by GBS culture as being GBS positive for both vaginal and rectal GBS colonization were randomly assigned to be orally treated with two placebo capsules or two probiotic capsules (containing L. rhamnosus GR-1 and L. reuteri RC-14) before bedtime until delivery. All women were tested for vaginal and rectal GBS colonization again by GBS culture on admission for delivery.RESULTS: Of the 110 participants, 99 completed the study (49 in the probiotic group and 50 in the placebo group). The GBS colonization results changed from positive to negative in 21 women in the probiotic group (42.9%) and in nine women in the placebo group (18.0%) during this period (Chi-square p=0.007).CONCLUSION: Oral probiotic containing L. rhamnosus GR-1 and L. reuteri RC-14 could reduce the vaginal and rectal GBS colonization rate in pregnant women.

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An Attitude of Gratitude Can Help You Live a Longer, Happier Life "IndyWatch Feed Health"

By Dr. Mercola

This article previously ran a few years ago but there are so many good reminders about the benefits of gratitude, I decided to share it with you again this year with a new video. I am grateful beyond words for your support, and for partnering with me to help people all over the world take control of their health.

Besides sharing time with family and friends over food, the primary ingredient of the American Thanksgiving holiday is gratitude. While it's certainly good to have an annual holiday to remind us to express gratitude, there's much to be said for the benefits of cultivating the spirit of thankfulness year-round.

People who are thankful for what they have are better able to cope with stress, have more positive emotions, and are better able to reach their goals. Scientists have even noted that gratitude is associated with improved health. As noted in the Harvard Mental Health Letter,1 "expressing thanks may be one of the simplest ways to feel better:"

"The word gratitude is derived from the Latin word gratia, which means grace, graciousness, or gratefulness (depending on the context). In some ways gratitude encompasses all of these meanings. Gratitude is a thankful appreciation for what an individual receives, whether tangible or intangible.

With gratitude, people acknowledge the goodness in their lives. In the process, people usually recognize that the source of that goodness lies at least partially outside themselves. As a result, gratitude also helps people connect to something larger than themselves as individuals whether to other people, nature, or a higher power.

...People feel and express gratitude in multiple ways. They can apply it to the past (retrieving positive memories and being thankful for elements of childhood or past blessings), the present (not taking good fortune for granted as it comes), and the future (maintaining a hopeful and optimistic attitude).

Regardless of the inherent or current level of someone's gratitude, it's a quality that individuals can successfully cultivate further."

GratitudeIt Does a Body Good

Dr. P. Murali Doraiswamy, head of biologic psychology at Duke University Medical Center once stated that: "If [thankfulness] were a drug, it would be the world's best-selling product with a health maintenance indication for every major organ system."...

Tasty Chocolate and Avocado Truffles Recipe "IndyWatch Feed Health"


Tasty Avocado Bomb Truffles

Recipe from Jennafer Ashley of Paleohacks



Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. "IndyWatch Feed Health"

PMID:  Benef Microbes. 2016 Nov 30 ;7(5):625-630. Epub 2016 Sep 6. PMID: 27596801 Abstract Title:  Supplementation with Lactobacillus rhamnosus SP1 normalises skin expression of genes implicated in insulin signalling and improves adult acne. Abstract:  Systemic supplementation with probiotics is increasingly being explored as a potential treatment strategy for skin disorders. Because both the gut-skin axis and dysregulation of insulin signalling have been implicated in the pathogenesis of adult acne, we designed the current study to evaluate the effect of supplementation with the probiotic strain Lactobacillus rhamnosus SP1 (LSP1) on skin expression of genes involved in insulin signalling and acne improvement in adult subjects. A pilot, randomised, double-blinded, placebo-controlled study was conducted with 20 adult subjects (14 females and 6 males; mean age: 33.73.3 years) with acne. Over a 12-week period, the probiotic group (n=10) consumed a liquid supplement containing LSP1 at a dose of 3109 cfu/day (75 mg/day), whereas the placebo group (n=10) received a liquid lacking probiotics. Paired skin biopsies - one obtained before treatment initiation and one obtained at the end of the 12-week treatment period - were analysed for insulin-like growth factor 1 (IGF1) and forkhead box protein O1 (FOXO1) gene expression. The clinical criterion for efficacy was the investigator's global improvement rating on a five-point scale. Compared with baseline, theprobiotic group showed a 32% (P

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Lactobacillus rhamnosus reduced the biofilm formation and filamentation of C. albicans in vitro "IndyWatch Feed Health"

PMID:  J Appl Microbiol. 2017 Jan ;122(1):201-211. Epub 2016 Nov 15. PMID: 27727499 Abstract Title:  Lactobacillus rhamnosus inhibits Candida albicans virulence factors in vitro and modulates immune system in Galleria mellonella. Abstract:  AIM: The aim of this study was to evaluate the potential anti-Candida effects of Lactobacillus rhamnosus ATCC 9595 on Candida albicans ATCC 18804 using in vitro and in vivo models.METHODS AND RESULTS: The in vitro analysis evaluated the effects of L. rhamnosus on C. albicans's biofilm formation by CFU count and metabolic activity, filamentation capacity, and adhesion (ALS3 and HWP1) and transcriptional regulatory gene (BCR1 and CPH1) expression. The in vitro results showed that both the L. rhamnosuscells and supernatant reduced C. albicans biofilm formation, filamentation and gene expression. In the in vivo study, the treatment with L. rhamnosus supernatant increased 80% the survival of Galleria mellonella larvae infected with C. albicans. Furthermore, the supernatant of L. rhamnosus recruited haemocytes into the haemolymph (21-fold increase).CONCLUSIONS: Lactobacillus rhamnosus reduced the biofilm formation and filamentation of C. albicans in vitro by negatively regulating all studied C. albicans genes. Lactobacillus rhamnosus protected G. mellonella against experimental candidiasis in vivo.SIGNIFICANCE AND IMPACT OF THE STUDY: This study is the first study to report the anti-Candida properties of L. rhamnosus ATCC 9595. The supernatant of this strain has immunomodulatory effects on the G. mellonella model and protects the larvae against pathogens.

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Probiotic compounds can be effective in improving pediatric NAFLD. "IndyWatch Feed Health"

PMID:  J Pediatr Gastroenterol Nutr. 2016 Oct 13. Epub 2016 Oct 13. PMID: 27753706 Abstract Title:  Effects of Probiotics on Non-Alcoholic Fatty Liver Disease in Obese Children and Adolescents: A Randomized Clinical Trial. Abstract:  OBJECTIVES: This trial aims to evaluate the effects of some probiotics on sonographic and biochemical non-alcoholic fatty liver disease (NAFLD).METHODS: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 310 colony forming units, CFU; Bifidobacterium lactis DSMZ 32269, 610 CFU; B bifidum ATCC SD6576, 210 CFU; L rhamnosus DSMZ 21690, 210 CFU) or placebo for 12 weeks.RESULTS: After intervention, in the probiotic group the mean levels of alanine aminotransferase (ALT) decreased from 32.8 (19.6) to 23.1(9.9) U/L (P=0.02); and mean aspartate aminotransferase (AST) decreased from 32.2 (15.7) to 24.3 (7.7) U/L (P=0.02). Likewise the mean cholesterol, LDL-C, and triglycerides, as well as waist circumference decreased in the intervention group, without significant change in weight, BMI, and BMI Z-score. After the trial, normal liver sonography was reported in 17 (53.1%) and 5 (16.5%) of patients in the intervention and placebo groups, respectively.CONCLUSIONS: The current findings suggest that a course of the abovementioned probiotic compound can be effective in improving pediatric NAFLD.

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Lactobacillus rhamnosus GG-derived products could reduce the risk of progression to postinfective motor disorders. "IndyWatch Feed Health"

PMID:  J Clin Gastroenterol. 2016 Nov/Dec;50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics&New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S140-S144. PMID: 27741159 Abstract Title:  Protective Role of Postbiotic Mediators Secreted by Lactobacillus rhamnosus GG Versus Lipopolysaccharide-induced Damage in Human Colonic Smooth Muscle Cells. Abstract:  BACKGROUND: Some beneficial effects of probiotics may be due to secreted probiotic-derived factors, identified as"postbiotic"mediators. The aim of this study was to evaluate whether supernatants harvested from Lactobacillus rhamnosus GG (LGG) cultures (ATCC53103 strain) protect colonic human smooth muscle cells (HSMCs) from lipopolysaccharide (LPS)-induced myogenic damage.MATERIALS AND METHODS: LGG was grown in de Man, Rogosa, Share medium at 37C and samples were collected in middle and late exponential, stationary, and overnight phases. Supernatants were recovered by centrifugation, filtered, and stored at -20C. The primary HSMCs culture was exposed for 24 hours to purified LPS of a pathogen strain of Escherichia coli (O111:B4) (1 g/mL) with and without supernatants. Postbiotic effects were evaluated on the basis of HSMCs morphofunctional alterations and interleukin-6 (IL-6) production. Data are expressed as meanSE (P

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Lactobacillus rhamnosus GG significantly reduced pro-inflammatory cytokine gene expression in colon and spleen post-pneumonia. "IndyWatch Feed Health"

PMID:  Clin Nutr. 2017 Dec ;36(6):1549-1557. Epub 2016 Oct 1. PMID: 27745813 Abstract Title:  Lactobacillus rhamnosus GG treatment improves intestinal permeability and modulates inflammatory response and homeostasis of spleen and colon in experimental model of Pseudomonas aeruginosa pneumonia. Abstract:  BACKGROUND & AIMS: Recent clinical trials and in vivo models demonstrate probiotic administration can reduce occurrence and improve outcome of pneumonia and sepsis, both major clinical challenges worldwide. Potential probiotic benefits include maintenance of gut epithelial barrier homeostasis and prevention of downstream organ dysfunction due tosystemic inflammation. However, mechanism(s) of probiotic-mediated protection against pneumonia remain poorly understood. This study evaluated potential mechanistic targets in the maintenance of gut barrier homeostasis following Lactobacillus rhamnosus GG (LGG) treatment in a mouse model of pneumonia.METHODS: Studies were performed in 6-8 week old FVB/N mice treated (o.g.) with or without LGG (10(9) CFU/ml) and intratracheally injected with Pseudomonas aeruginosa or saline. At 4, 12, and 24 h post-bacterial treatment spleen and colonic tissue were collected for analysis.RESULTS: Pneumonia significantly increased intestinal permeability and gut claudin-2. LGG significantly attenuated increased gut permeability and claudin-2 following pneumonia back to sham control levels. As mucin expression is key to gut barrier homeostasis we demonstrate that LGG can enhance goblet cell expression and mucin barrier formation versus control pneumonia animals. Further as Muc2 is a key gut mucin, we show LGG corrected deficient Muc2 expression post-pneumonia. Apoptosis increased in both colon and spleen post-pneumonia, and this increase was significantly attenuated by LGG. Concomitantly, LGG corrected pneumonia-mediated loss of cell proliferation in colon and significantly enhanced cell proliferation in spleen. Finally, LGG significantly reduced pro-inflammatory cytokine gene expression in colon and spleen post-pneumonia.CONCLUSIONS: These data demonstrate LGG can maintain intestinal barrier homeostasis by enhancing gut mucin expression/barrier formation, reducing apoptosis, and improving cell proliferation. This was accompanied by reduced pro-inflammatory cytokine expression in the gut and in a downstream organ (spleen). These may serve as potential mechanistic targets to explain LGG's protection against pneumonia in the clinical and in vivo setting.

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Lactobacillus is able to alter the virulence and the sensitivity profile of Candida albicans. "IndyWatch Feed Health"

PMID:  J Appl Microbiol. 2016 Dec ;121(6):1737-1744. Epub 2016 Oct 24. PMID: 27606962 Abstract Title:  Lactobacillus is able to alter the virulence and the sensitivity profile of Candida albicans. Abstract:  AIMS: The study investigated whether the interaction with Lactobacillus rhamnosus (ATCC7469) interfere with the expression of virulence factors by Candida albicans (ATCC18804).METHODS AND RESULTS: These micro-organisms were grown in biofilms for 24, 48 and 72 h, Candida was isolated and the expression of the major virulence factors were investigated. The production of phospholipase, protease and haemolysin were observed in appropriate media; observation of germ tubes formation in serum; biofilm formation, after growth in microtitre plates and reading in spectrophotometer. Candida was also tested for antifungal sensitivity to amphotericin B, fluconazole and ketoconazole. The results were compared with the cells of Candida grown in the absence of lactobacilli (control group). Candida cells, which interacted with Lact. rhamnosus (test group), showed significantly lower proteinase and haemolysin activity, when compared with control group. The germ tube formation and biofilm formation capacity also decreased in tested groups, which demonstrated alterations in susceptibility to antifungal drugs.CONCLUSIONS: The results suggest that Lact. rhamnosus is able to influence the expression of virulence factors by C. albicans and can alter its antifungal sensitivity profile.SIGNIFICANCE AND IMPACT OF THE STUDY: These results suggest reduction in the pathogenicity of Candida and improvement in candidiasis therapy and control.

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L. rhamnosus GG improved atherosclerosis with the pharmaceutical telmisartan. "IndyWatch Feed Health"

PMID:  BMC Microbiol. 2016 Nov 8 ;16(1):264. Epub 2016 Nov 8. PMID: 27821063 Abstract Title:  High fat diet induced atherosclerosis is accompanied with low colonic bacterial diversity and altered abundances that correlates with plaque size, plasma A-FABP and cholesterol: Abstract:  BACKGROUND: Atherosclerosis appears to have multifactorial causes - microbial component like lipopolysaccharides (LPS) and other pathogen associated molecular patterns may be plausible factors. The gut microbiota is an ample source of such stimulants, and its dependent metabolites and altered gut metagenome has been an established link to atherosclerosis. In this exploratory pilot study, we aimed to elucidate whether microbial intervention with probiotics L. rhamnosus GG (LGG) or pharmaceuticals telmisartan (TLM) could improve atherosclerosis in a gut microbiota associated manner.METHODS: Atherosclerotic phenotype was established by 12 weeks feeding of high fat (HF) diet as opposed to normal chow diet (ND) in apolipoprotein E knockout (ApoE(-/-)) mice. LGG or TLM supplementation to HF diet was studied.RESULTS: Both LGG and TLM significantly reduced atherosclerotic plaque size and improved various biomarkers including endotoxin to different extents. Colonial microbiota analysis revealed that TLM restored HF diet induced increase in Firmicutes/Bacteroidetes ratio and decrease in alpha diversity; and led to a more distinct microbial clustering closer to ND in PCoA plot. Eubacteria, Anaeroplasma, Roseburia, Oscillospira and Dehalobacteria appeared to be protective against atherosclerosis and showed significant negative correlation with atherosclerotic plaque size and plasma adipocyte - fatty acid binding protein (A-FABP) and cholesterol.CONCLUSION: LGG and TLM improved atherosclerosis with TLM having a more distinct alteration in the colonic gut microbiota. Altered bacteria genera and reduced alpha diversity had significant correlations to atherosclerotic plaque size, plasma A-FABP and cholesterol. Future studies on such bacterial functional influence in lipid metabolism will be warranted.

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Orally administered multispecies probiotic formulations to prevent uro-genital infections. "IndyWatch Feed Health"

PMID:  Arch Gynecol Obstet. 2017 Jan ;295(1):163-172. Epub 2016 Nov 9. PMID: 27826653 Abstract Title:  Orally administered multispecies probiotic formulations to prevent uro-genital infections: a randomized placebo-controlled pilot study. Abstract:  PURPOSE: The aim of this study was to evaluate in the vagina of 60 pre-menopausal women the detection of orally administered multispecies probiotic formulations showing anti-microbial properties in test in vitro.METHODS: A randomized, double-blind, three-arm parallel pilot study was carried out on 60 pre-menopausal women. Subjects were randomly divided in three groups (F_1, F_2, F_3). Each group received a daily oral administration of probiotic mixtures (for 14 days and at the day 21, 7 days after the wash-out) containing: Lactobacillus acidophilus and Lactobacillus reuteri (F_1), or Lactobacillus plantarum, Lactobacillus rhamnosus and Bifidobacterium animalis subsp. lactis (F_2), or placebo (F_3), respectively. Vaginal swabs were collected at four experimental times, at t0 and at t7, t14 and t21 days, and analyzed by qPCR. At the same time, the anti-microbial activity of the probiotic formulations was verified by assays in vitro against microorganisms as Escherichia coli and Candida albicans.RESULTS: L. acidophilus and L. reuteri as well as L. plantarum, L. rhamnosus and B. lactis were significantly increased on 7 days in the groups administered with F_1 and F_2, respectively, compared to group F_3. A similar significant trend was observed on 21 days, 7 days after the wash-out. F_1 and F_2 showed coherent anti-microbial properties.CONCLUSION: Both probiotic formulations F_1 and F_2, chosen because of their anti-microbial activity against pathogens responsible for vaginal dysbiosis and infections, led to vaginal detection and enhancement of the amount of species of formulates when orally administered. This work provides the basis for further clinical investigations of the F_1 and F_2 capacity to prevent or treat uro-genital infections.

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High protective efficacy of probiotics and rice bran against human norovirus infection and diarrhea. "IndyWatch Feed Health"

PMID:  Front Microbiol. 2016 ;7:1699. Epub 2016 Nov 2. PMID: 27853451 Abstract Title:  High Protective Efficacy of Probiotics and Rice Bran against Human Norovirus Infection and Diarrhea in Gnotobiotic Pigs. Abstract:  Probiotics have been recognized as vaccine adjuvants and therapeutic agents to treat acute gastroenteritis in children. We previously showed that rice bran (RB) reduced human rotavirus diarrhea in gnotobiotic pigs. Human noroviruses (HuNoVs) are the major pathogens causing non-bacterial acute gastroenteritis worldwide. In this study, Lactobacillus rhamnosus GG (LGG) and Escherichia coli Nissle 1917 (EcN) were first screened for their ability to bind HuNoV P particles and virions derived from clinical samples containing HuNoV genotype GII.3 and GII.4, then the effects of LGG+EcN and RB on HuNoV infection and diarrhea were investigated using the gnotobiotic pig model. While LGG+EcN colonization inhibited HuNoV shedding, probiotic cocktail regimens in which RB feeding started 7 days prior to or 1 day after viral inoculation in the LGG+EcN colonized gnotobiotic pigs exhibited high protection against HuNoV diarrhea and shedding, characterized by significantly reduced incidence (89 versus 20%) and shorter mean duration of diarrhea (2.2 versus 0.2 days), as well as shorter mean duration of virus shedding (3.2 versus 1.0 days). In both probiotic cocktail groups, the diarrhea reduction rates were 78% compared with the control group, and diarrhea severity was reduced as demonstrated by the significantly lower cumulative fecal scores. The high protective efficacy of the probiotic cocktail regimens was attributed to stimulation of IFN-(+) T cell responses, increased production of intestinal IgA and IgG, and maintenance of healthy intestinal morphology (manifested as longer villi compared with the control group). Therefore, probiotic cocktail regimens containing LGG+EcN and RB may represent highly efficacious strategies to prevent and treat HuNoV gastroenteritis, and potentially other human enteric pathogens.

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Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation. "IndyWatch Feed Health"

PMID:  Benef Microbes. 2017 Apr 26 ;8(2):243-255. Epub 2016 Dec 23. PMID: 28008783 Abstract Title:  Lactobacillus rhamnosus NCDC17 ameliorates type-2 diabetes by improving gut function, oxidative stress and inflammation in high-fat-diet fed and streptozotocintreated rats. Abstract:  Restoration of dysbiosed gut microbiota through probiotic may have profound effect on type 2 diabetes. In the present study, rats were fed high fat diet (HFD) for 3 weeks and injected with low dose streptozotocin to induce type 2 diabetes. Diabetic rats were then fed Lactobacillus rhamnosus NCDC 17 and L. rhamnosus GG with HFD for six weeks. L. rhamnosus NCDC 17 improved oral glucose tolerance test, biochemical parameters (fasting blood glucose, plasma insulin, glycosylated haemoglobin, free fatty acids, triglycerides, total cholesterol, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol), oxidative stress (thiobarbituric acid reactive substance and activities of catalase, superoxide dismutase and glutathione peroxidase in blood and liver), bifidobacteria and lactobacilli in cecum, expression of glucagon like peptide-1 producing genes in cecum, and adiponection in epididymal fat, while decreased propionate proportions (%) in caecum, and expression of tumour necrosis factor- and interlukin-6 in epididymal fat of diabetic rats as compared to diabetes control group. These findings offered a base for the use of L. rhamnosus NCDC 17 for the improvement and early treatment of type 2 diabetes.

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EHCF+LGG reduces the incidence of other allergic manifestations and hastens the development of oral tolerance in children with IgE-mediated CMA. "IndyWatch Feed Health"

PMID:  J Allergy Clin Immunol. 2017 Jun ;139(6):1906-1913.e4. Epub 2016 Dec 30. PMID: 28043872 Abstract Title:  Extensively hydrolyzed casein formula containing Lactobacillus rhamnosus GG reduces the occurrence of other allergic manifestations in children with cow's milk allergy: 3-year randomized controlled trial. Abstract:  BACKGROUND: Children with cow's milk allergy (CMA) have an increased risk of other allergic manifestations (AMs).OBJECTIVE: We performed a parallel-arm randomized controlled trial to test whether administration of an extensively hydrolyzed casein formula (EHCF) containing the probiotic Lactobacillus rhamnosus GG (LGG) can reduce the occurrence of other AMs in children with CMA.METHODS: Children with IgE-mediated CMA were randomly allocated to the EHCF or EHCF+LGG groups and followed for 36 months. The main outcome was occurrence of at least 1 AM (eczema, urticaria, asthma, and rhinoconjunctivitis). The secondary outcome was tolerance acquisition, which was defined as the negativization of a double-blind food challenge results at 12, 24, and 36 months. AMs were diagnosed according to standardized criteria. Tolerance acquisition was evaluated every 12 months.RESULTS: A total of 220 children (147 boys [67%]) with a median age of 5.0 months (interquartile range, 3.0-8.0 months) were randomized; 110 children were placed in the EHCF group, and 110 children were placed in the EHCF+LGG group. In the complete case analysis the absolute risk difference for the occurrence of at least 1 AM over 36 months was -0.23 (95% CI, -0.36 to-0.10; P 

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Lactobacillus rhamnosus GG conditioned medium prevents E. coli meningitis by inhibiting nuclear factor-B pathway. "IndyWatch Feed Health"

PMID:  Nan Fang Yi Ke Da Xue Xue Bao. 2017 Jan 20 ;37(1):24-29. PMID: 28109094 Abstract Title:  [Lactobacillus rhamnosus GG conditioned medium prevents E. coli meningitis by inhibiting nuclear factor-B pathway]. Abstract:  OBJECTIVE: To investigate whether Lactobacillus rhamnosus GG conditioned medium(LGG-CM)has preventive effect against E. coli K1-induced neuropathogenicity in vitro by inhibiting nuclear factor-B (NF-B) signaling pathway.METHODS: An in vitro blood-brain barrier (BBB) model was constructed using human brain microvascular endothelial cells (HBMECs). The effect of LGG-CM on E. coli-actived NF-B signaling pathway was assayed using Western blotting. Invasion assay and polymorphonuclear leukocyte (PMN) transmigration assay were performed to explore whether LGG-CM could inhibit E. coli invasion and PMN transmigration across the BBB in vitro. The expressions of ZO-1 and CD44 were detected using Western blotting and immunofluorescence. The changes of trans-epithelial electric resistance (TEER) and bacterial translocation were determined to evaluate the BBB permeability.RESULTS: Pre-treament with LGG-CM inhibited E. coli-activated NF-B signaling pathway in HBMECs and decreased the invasion of E. coli K1 and transmigration of PMN. Western blotting showed that LGG-CM could alleviate E. coli-induced up-regulation of CD44 and down-regulation of ZO-1 expressions in HBMECs. In addition, pre-treatment with LGG-CM alleviated E. coli K1-induced reduction of TEER and suppressed bacterial translocation across the BBB in vitro.CONCLUSION: LGG-CM can block E. coli-induced activation of NF-B signaling pathway and thereby prevents E. coli K1-induced neuropathogenicity by decreasing E. coli K1 invasion rates and PMN transmigration.

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Lactobacillus rhamnosus could be useful in minimizing the harmful consequence induced by 5-FU. "IndyWatch Feed Health"

PMID:  Probiotics Antimicrob Proteins. 2017 Mar 8. Epub 2017 Mar 8. PMID: 28275899 Abstract Title:  Spray Dried Formulation of 5-Fluorouracil Embedded with Probiotic Biomass: In Vitro and In Vivo Studies. Abstract:  The present study is utilizing the targeted therapeutic approach and antioxidant potential of selected probiotic biomass in mitigating toxic side effects of chemotherapeutic agents. Multicomponent carrier system consisting of 5-fluorouracil (5-FU) and selected probiotic strain with higher free radical scavenging activity was prepared using spray drying technique. Prepared spray dried microparticles were characterized for various physical, pharmaceutical, and biopharmaceutical properties including particle size, moisture content, entrapment efficiency, in vitro drug release, DSC, XRD, cell uptake, histopathology, and pharmacokinetic studies. In addition to the above, optimized formulation was subjected to in vivo targeting efficacy studies using radiographic technique. Optimized formulation meets the necessary physical requirement for pharmaceutical powder. X-ray studies revealed that the prepared spray dried formulations are able to target the colon. Pharmacokinetic endpoints with an extended t 1/2 and lower C max indicate lower systemic toxicity. Intact nature of colonic epithelium in experimental formulation clearly demonstrates the protective role of Lactobacillus rhamnosus in minimizing the harmful consequence induced by 5-FU. Existing outcomes provide the basis for a combination of targeted therapeutic approach with natural antioxidant capacity of potential probiotic strain which could help to mitigate the problems associated with traditional chemotherapy.

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L. paracasei 28.4 can modulate the immune system of G. mellonella and protect against candidiasis. "IndyWatch Feed Health"

PMID:  PLoS One. 2017 ;12(3):e0173332. Epub 2017 Mar 7. PMID: 28267809 Abstract Title:  Lactobacillus paracasei modulates the immune system of Galleria mellonella and protects against Candida albicans infection. Abstract:  Probiotics have been described as a potential strategy to control opportunistic infections due to their ability to stimulate the immune system. Using the non-vertebrate model host Galleria mellonella, we evaluated whether clinical isolates of Lactobacillus spp. are able to provide protection against Candida albicans infection. Among different strains of Lactobacillus paracasei, Lactobacillus rhamnosus and Lactobacillus fermentum, we verified that L. paracasei 28.4 strain had the greatest ability to prolong the survival of larvae infected with a lethal dose of C. albicans. We found that the injection of 107 cells/larvae of L. paracasei into G. mellonella larvae infected by C. albicans increased the survival of these insects compared to the control group (P = 0.0001). After that, we investigated the immune mechanisms involved in the protection against C. albicans infection, evaluating the number of hemocytes and the gene expression of antifungal peptides. We found that L. paracasei increased the hemocyte quantity (2.38 x 106 cells/mL) in relation to the control group (1.29 x 106 cells/mL), indicating that this strain is capable of raising the number of circulating hemocytes into the G. mellonella hemolymph. Further, we found that L. paracasei 28.4 upregulated genes that encode the antifungal peptides galiomicin and gallerymicin. In relation to the control group, L. paracasei 28.4 increased gene expression of galiomicin by 6.67-fold and 17.29-fold for gallerymicin. Finally, we verified that the prophylactic provision of probiotic led to a significant reduction of the number of fungal cells in G. mellonella hemolymph. In conclusion, L. paracasei 28.4 can modulate the immune system of G. mellonella and protect against candidiasis.

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Probiotic administration improves sperm quality in asthenozoospermic human donors. "IndyWatch Feed Health"

PMID:  Benef Microbes. 2017 Apr 26 ;8(2):193-206. Epub 2017 Mar 27. PMID: 28343402 Abstract Title:  Probiotic administration improves sperm quality in asthenozoospermic human donors. Abstract:  The objective of this study is to analyse the effect of the ingestion of two selected antioxidant probiotics strains (Lactobacillus rhamnosus CECT8361 and Bifidobacterium longum CECT7347) on sperm quality parameters in asthenozoospermic males after three and six weeks of administration. Nine asthenozoospermic men without any medical treatment under similar diet conditions participated in the study. The quality of individual sperm samples was evaluated before (previous to ingestion), during (after 3 and 6 weeks of ingestion) and after probiotic administration (3 and 6 weeks after finishing the treatment). Sperm motility was evaluated by computer-assisted sperm analysis system, DNA fragmentation by sperm chromatin structure assay, cell viability by flow cytometry and measurement of intracellular H2O2 (reactive oxygen species; ROS) by flow cytometry using dichloro-dihydrofluorescein diacetate. Sperm motility was drastically improved after the treatment (approximately 6 fold change), DNA fragmentation was statistically reduced after probiotic administration from (approximately 1.2 fold change) and intracellular H2O2 level was decreased (approximately 3.5 fold change). Cell viability was not affected by the treatment. The significant improvement in sperm motility and the decrease in DNA fragmentation reported in this study provide preliminary evidence that probiotics could be administrated to improve motility and decrease DNA fragmentation and ROS levels in asthenozoospermic human males.

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Lactobacillus rhamnosus HN001 supplementation from 14 to 16 weeks gestation may reduce gestational diabetes mellitus prevalence. "IndyWatch Feed Health"

PMID:  Br J Nutr. 2017 Mar ;117(6):804-813. Epub 2017 Apr 3. PMID: 28367765 Abstract Title:  Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Abstract:  The study aims to assess whether supplementation with the probiotic Lactobacillus rhamnosus HN001 (HN001) can reduce the prevalence of gestational diabetes mellitus (GDM). A double-blind, randomised, placebo-controlled parallel trial was conducted in New Zealand (NZ) (Wellington and Auckland). Pregnant women with a personal or partner history of atopic disease were randomised at 14-16 weeks' gestation to receive HN001 (6109 colony-forming units) (n 212) or placebo (n 211) daily. GDM at 24-30 weeks was assessed using the definition of the International Association of Diabetes and Pregnancy Study Groups (IADPSG) (fasting plasma glucose 51 mmol/l, or 1 h post 75 g glucose level at 10 mmol/l or at 2 h 85mmol/l) and NZ definition (fasting plasma glucose 55 mmol/l or 2 h post 75 g glucose at 9 mmol/l). All analyses were intention-to-treat. A total of 184 (87 %) women took HN001 and 189 (90 %) women took placebo. There was a trend towards lower relative rates (RR) of GDM (IADPSG definition) in the HN001 group, 059 (95 % CI 032, 108) (P=008). HN001 was associated with lower rates of GDM in women aged 35 years (RR 031; 95 % CI 012, 081, P=0009) and women with a history of GDM (RR 000; 95 % CI 000, 066, P=0004). These rates did not differ significantly from thoseof women without these characteristics. Using the NZ definition, GDM prevalence was significantly lower in the HN001 group, 21 % (95 % CI 06, 52), v. 65 % (95 % CI 35, 109) in the placebo group (P=003). HN001 supplementation from 14 to 16 weeks' gestation may reduce GDM prevalence, particularly among older women and those with previous GDM.

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Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice. "IndyWatch Feed Health"

PMID:  Benef Microbes. 2017 May 30 ;8(3):393-405. Epub 2017 May 15. PMID: 28504568 Abstract Title:  Lactobacillus rhamnosus CRL1505 nasal administration improves recovery of T-cell mediated immunity against pneumococcal infection in malnourished mice. Abstract:  Immunobiotic lactic acid bacteria have become an interesting alternative for the prevention of respiratory infections. Previously, we demonstrated that the nasal administration of Lactobacillus rhamnosus CRL1505, during repletion of malnourished mice, resulted in diminished susceptibility to the challenge with the respiratory pathogen Streptococcus pneumoniae. Considering the known alterations induced by malnutrition on T lymphocytes and the importance of this cell population on the protection against respiratory pathogens, we aimed to study the effect of L. rhamnosus CRL1505 nasal administration on the recovery of T cell-mediated defences against pneumococcal infection in malnourished mice under nutritional recovery. Malnourished mice received a balanced conventional diet (BCD) for seven days or BCD for seven days with nasal L. rhamnosus CRL1505 supplementation during last two days of the treatment. After the treatments mice were infected with S. pneumoniae. Flow cytometry studies were carried out in bone marrow, thymus, spleen and lung to study T cells, and Th1/Th2 cytokine profiles were determined in broncho-alveolar lavages and serum. The administration of CRL1505 strain to malnourished mice under recovery reduced quantitative and qualitative alterations of CD4(+) T cells in the bone marrow, thymus, spleen and lung induced by malnutrition. In addition, CRL1505 treatment augmented Th2-cytokines (interleukin 10 and 4) in respiratory and systemic compartments after pneumococcal infection. These results show that modulation of CD4(+) T lymphocytes induced by L. rhamnosus CRL1505 has an important role in the beneficial effect induced by this strain on the recovery of malnourished mice. These data also indicate that nasally administered L. rhamnosus CRL1505 may represent a non-invasive alternative to modulate and improve the T cell-mediated immunity against respiratory pathogens in immunocompromised malnourished hosts.

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Probiotics have beneficial effects on both behavioural and gastrointestinal manifestations of autism spectrum disorders. "IndyWatch Feed Health"

PMID:  Nutr Neurosci. 2017 Jul 7:1-6. Epub 2017 Jul 7. PMID: 28686541 Abstract Title:  The role of probiotics in children with autism spectrum disorder: A prospective, open-label study. Abstract:  OBJECTIVE: There are limited data on the efficacy of probiotics in children with ASD, therefore, this study aims to evaluate the efficacy and tolerability of probiotics in an Egyptian cohort of children with ASD.METHODS: Gastrointestinal (GI) flora were assessed by quantitative real-time PCR of stool samples of 30 autistic children from 5 to 9 years old. GI symptoms of autistic children were assessed with a modified six-item Gastrointestinal Severity Index (6-GSI) questionnaire, and autistic symptoms were assessed with Autism Treatment Evaluation Checklist (ATEC) before and after 3 months of supplementation of probiotics nutritional supplement formula (each gram contains 10010(6) colony forming units of three probiotic strains; Lactobacillus acidophilus, Lactobacillus rhamnosus and Bifidobacteria longum).RESULTS: After probiotic supplementation, the stool PCR of autistic children showed increases in the colony counts of Bifidobacteria and Lactobacilli levels, with a significant reduction in their body weight as well as significant improvements in the severity of autism (assessed by the ATEC), and gastrointestinal symptoms (assessed by the 6-GSI) compared to the baseline evaluated at the start of the study.CONCLUSIONS: We concluded that probiotics have beneficial effects on both behavioral and GI manifestations of ASD. Probiotics (a non-pharmacological and relatively risk-free option) could be recommended for children with ASD as an adjuvant therapy. At this stage, this study is a single center with a small number of patients and a great deal of additional wide-scale randomized controlled trials are needed to critically confirm the efficacy of probiotics in ASD.TRIAL REGISTRATION NUMBER: UMIN-CTR Study Design: Trial Number UMIN000026157.

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Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity. "IndyWatch Feed Health"

PMID:  Sci Rep. 2017 Jul 17 ;7(1):5512. Epub 2017 Jul 17. PMID: 28717234 Abstract Title:  Dietary lipid content reorganizes gut microbiota and probiotic L. rhamnosus attenuates obesity and enhances catabolic hormonal milieu in zebrafish. Abstract:  In the present study, we explored whether dietary lipid content influences the gut microbiome in adult zebrafish. Diets containing three different lipid levels (high [HFD], medium [MFD], and low [LFD]) were administered with or without the supplementation of Lactobacillus rhamnosus (P) to zebrafish in order to explore how the dietary lipid content may influence the gut microbiome. Dietary lipid content shifted the gut microbiome structure. The addition of L. rhamnosus in the diets, induced transcriptional reduction of orexigenic genes, upregulation of anorexigenic genes, and transcriptional decrease of genes involved in cholesterol and triglyceride (TAG) metabolism, concomitantly with lower content of cholesterol and TAG. Probiotic feeding also decreased nesfatin-1 peptide in HFD-P and attenuated weight gain in HFD-P and MFD-P fed zebrafish, but not in LFD-P group. Intestinal ultrastructure was not affected by dietary fat level or probiotic inclusion. In conclusion, these findings underline the role of fat content in the diet in altering gut microbiota community by shifting phylotype composition and highlight the potential of probiotics to attenuate high-fat diet-related metabolic disorder.

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Women who received HN001 had significantly lower depression and anxiety scores in the postpartum period. "IndyWatch Feed Health"

PMID:  EBioMedicine. 2017 Oct ;24:159-165. Epub 2017 Sep 14. PMID: 28943228 Abstract Title:  Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial. Abstract:  BACKGROUND: Probiotics may help to prevent symptoms of anxiety and depression through several putative mechanisms.OBJECTIVE: The aim of this study was to evaluate the effect of Lactobacillus rhamnosus HN001 (HN001) given in pregnancy and postpartum on symptoms of maternal depression and anxiety in the postpartum period. This was a secondary outcome, the primary outcome being eczema in the offspring at 12months of age.DESIGN, SETTING, PARTICIPANTS: A randomised, double-blind, placebo-controlled trial of the effect of HN001 on postnatal mood was conducted in 423 women in Auckland and Wellington, New Zealand. Women were recruited at 14-16weeks gestation.INTERVENTION: Women were randomised to receive either placebo or HN001 daily from enrolment until 6months postpartum if breastfeeding.OUTCOME MEASURES: Modified versions of the Edinburgh Postnatal Depression Scale and State Trait Anxiety Inventory were used to assess symptoms of depression and anxiety postpartum.TRIAL REGISTRATION: Australia NZ Clinical Trials Registry: ACTRN12612000196842.FINDINGS: 423 women were recruited between December 2012 and November 2014. 212 women were randomised to HN001 and 211 to placebo. 380 women (89.8%) completed the questionnaire on psychological outcomes, 193 (91.0%) in the treatment group and 187 (88.6%) in the placebo group. Mothers in the probiotic treatment group reported significantly lower depression scores (HN001 mean=77 (SD=54), placebo 90 (60); effect size -12, (95% CI -23, -01), p=0037) and anxiety scores (HN001 120 (40), placebo 130 (40); effect size -10 (-19, -02), p=0014) than those in the placebo group. Rates of clinically relevant anxiety on screening (score>15) were significantly lower in the HN001 treated mothers (OR=044 (026, 073), p=0002).INTERPRETATION: Women who received HN001 had significantly lower depression and anxiety scores in the postpartum period. This probiotic may be useful for the prevention or treatment of symptoms of depression and anxiety postpartum.FUNDING SOURCE: Health Research Council of New Zealand (11/318) and Fonterra Co-operative Group Ltd.

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Both L. rhamnosus NCDC 298 with FOS can be used as an effective synbiotic combination for secretory antidiarrheal fermented dairy formulations. "IndyWatch Feed Health"

PMID:  Probiotics Antimicrob Proteins. 2017 Sep 25. Epub 2017 Sep 25. PMID: 28948579 Abstract Title:  Effect of Lactobacillus rhamnosus NCDC 298 with FOS in Combination on Viability and Toxin Production of Enterotoxigenic Escherichia coli. Abstract:  The present study was to investigate the utilization of prebiotics by Lactobacillus rhamnosus NCDC 298 and its synergistic adversary effect on both population and production of heat-labile (LT) toxin in enterotoxigenic Escherichia coli (ETEC). To select suitable prebiotic in order to enhance functionality, its utilization and the prebiotic activity score was examined. Antivirulence effect on ETEC was inspected by its inactivation rate and heat-labile toxin production in presence of different synbiotic combination. L. rhamnosus NCDC 298 strain grown well on media supplemented with fructooligosaccharides (FOS) and galactooligosaccharides (GOS), whereas significant inactivation of ETEC was observed when FOS was added to the co-culture medium. Significant decrease in LT enterotoxin was seen through GM1 ganglioside enzyme linked immunoassay (GM1 ELISA), when ETEC has grown with L. rhamnosus NCDC 298 and FOS. Short-chain FOS proved to be the most effective substrate, improving antagonistic activity for L. rhamnosus NCDC 298. Both L. rhamnosus NCDC 298 with FOS can be used as an effective synbiotic combination for secretory antidiarrheal fermented dairy formulations.

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Lactobacillus rhamnosus PB01 (DSM 14870) supplementation affects markers of sperm kinematic parameters in a diet-induced obesity mice model. "IndyWatch Feed Health"

PMID:  PLoS One. 2017 ;12(10):e0185964. Epub 2017 Oct 10. PMID: 29016685 Abstract Title:  Lactobacillus rhamnosus PB01 (DSM 14870) supplementation affects markers of sperm kinematic parameters in a diet-induced obesity mice model. Abstract:  Probiotics have been proposed as alternatives to pharmacological products in several medical conditions including the modulation of obesity, which is frequently associated with poor semen quality. However, effects of probiotics on male fertility have been less investigated. This study assessed the effect of Lactobacillus rhamnosus PB01 (DSM-14870) on sperm kinematic parameters in Normal-weight (NW) and diet-induced obese (DIO) models. NW and DIO C57BL/6NTac mice were divided into two subgroups with or without a single daily dose (1x109CFU) of L. rhamnosus for four weeks. Sperm motility and kinematics together with blood lipid profiles and reproductive hormone levels were assessed using the sperm class analyzer system. Probiotic supplementation increased serum testosterone, LH and FSH levels in both NW and DIO groups resulting in significantly (P

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The results suggests that probiotic use may be beneficial in the prevention of antibiotic-associated diarrhea among outpatients. "IndyWatch Feed Health"

PMID:  Antibiotics (Basel). 2017 Oct 12 ;6(4). Epub 2017 Oct 12. PMID: 29023420 Abstract Title:  Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients-A Systematic Review and Meta-Analysis. Abstract:  A common adverse effect of antibiotic use is diarrhea. Probiotics are living microorganisms, which, upon oral ingestion, may prevent antibiotic-associated diarrhea (AAD) by the normalization of an unbalanced gastrointestinal flora. The objective of this systematic review was to assess the benefits and harms of probiotics used for the prevention of AAD in an outpatient setting. A search of the PubMed database was conducted and yielded a total of 17 RCTs with 3631 participants to be included in the review. A meta-analysis was conducted for the primary outcome: the incidence of AAD. The pooled results found that AAD was present in 8.0% of the probiotic group compared to 17.7% in the control group (RR 0.49, 95% CI 0.36 to 0.66; I = 58%), and the species-specific results were similar regarding the probiotic strains L. rhamnosus GG and S. boulardii. However, the overall quality of the included studies was moderate. A meta-analysis of the ten trials reporting adverse events demonstrated no statistically significant differences in the incidence of adverse events between the intervention and control group (RD 0.00, 95% CI -0.02 to 0.02, 2.363 participants). The results suggests that probiotic use may be beneficial in the prevention of AAD among outpatients. Furthermore, the use of probiotics appears safe.

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Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. "IndyWatch Feed Health"

PMID:  PLoS One. 2017 ;12(10):e0184438. Epub 2017 Oct 12. PMID: 29023454 Abstract Title:  Antifungal defense of probiotic Lactobacillus rhamnosus GG is mediated by blocking adhesion and nutrient depletion. Abstract:  Candida albicans is an inhabitant of mucosal surfaces in healthy individuals but also the most common cause of fungal nosocomial blood stream infections, associated with high morbidity and mortality. As such life-threatening infections often disseminate from superficial mucosal infections we aimed to study the use of probiotic Lactobacillus rhamnosus GG (LGG) in prevention of mucosal C. albicans infections. Here, we demonstrate that LGG protects oral epithelial tissue from damage caused by C. albicans in our in vitro model of oral candidiasis. Furthermore, we provide insights into the mechanisms behind this protection and dissect direct and indirect effects of LGG on C. albicans pathogenicity. C. albicans viability was not affected by LGG. Instead, transcriptional profiling using RNA-Seq indicated dramatic metabolic reprogramming of C. albicans. Additionally, LGG had a significant impact on major virulence attributes, including adhesion, invasion, and hyphal extension, whose reduction, consequently, prevented epithelial damage. This was accompanied by glucose depletion and repression of ergosterol synthesis, caused by LGG, but also due to blocked adhesion sites. Therefore, LGG protects oral epithelia against C. albicans infection by preventing fungal adhesion, invasion and damage, driven, at least in parts, by metabolic reprogramming due to nutrient limitation caused by LGG.

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Lactobacillus rhamnosus GG ameliorates inflammation induced by infection with the monophasic variant Salmonella. "IndyWatch Feed Health"

PMID:  Vet Microbiol. 2017 Oct ;210:91-100. Epub 2017 Aug 20. PMID: 29103703 Abstract Title:  Anti-inflammatory capacity of Lactobacillus rhamnosus GG in monophasic variant Salmonella infected piglets is correlated with impeding NLRP6-mediated host inflammatory responses. Abstract:  In this study, we investigated the effect of Lactobacillus rhamnosus GG strain (LGG) in ameliorating enteritis in newly weaned pigs following challenge with a monophasic variant of Salmonella enterica serovar Typhimurium (serotyped as 4,[5],12:i:-), which has been linked to disease in humans and livestocks over the past 10 years. In weaned pigs, S. enterica serovar 4,[5],12:i:- induced the mRNA expression of toll like receptor (TLR) 5 and TLR4, while increasing interleukin (IL)-8 and IL-6 mRNA expression in the jejunum. The monophasic variant Salmonella stimulated the expression of nucleotide-binding oligomerization domain-containing protein 1/2 (NOD1/2) mRNA in the ileum, which was accompanied by phosphorylation of IB-, an inhibitor of NF-B, activating the NF-B pathway and promoting the release of inflammatory cytokines. Oral administration of LGG attenuated the Salmonella-induced increases in the expression of NOD1 mRNA of jejunal and ileal tissues. LGG promoted the secretion of immunoglobulin A in different intestinal segments but did not induce expression of polymeric immunoglobulin receptor. LGG also impeded the activation of the Nod-like receptor protein (NLRP) 6/apoptosis-associated speck-like protein/caspase-1 inflammasome and decreased the production of IL-18 in the ileum during Salmonellainfection. In contrast, activation of the NLRP3 inflammasome was not altered. Our data indicate that LGG accelerated the clearance of Salmonella in the early phase of infection and prevented the excessive inflammatory responses in S. enterica serovar 4,[5],12:i:- model. LGG ameliorates inflammationinduced by infection with the monophasic variant Salmonella via inhibition of the canonical NF-B pathway and attenuation of the NLRP6-mediated inflammasome in the intestine.

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These results indicated that LGG enhanced the anticancer effects of geniposide in HSC-3 cells. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2017 Nov ;14(5):4586-4594. Epub 2017 Sep 5. PMID: 29104666 Abstract Title:  Lactobacillus raises in vitro anticancer effect of geniposide in HSC-3 human oral squamous cell carcinoma cells. Abstract:  The present study determined the ability of the Lactobacillus rhamnosus GG strain (LGG) to enhance the anticancer effects of geniposide on HSC-3 human oral squamous carcinoma cells. LGG (1.010(3) CFU/ml) on its own had no impact on human oral keratinocytes and HSC-3 cancer cells. Geniposide (25 or 50 g/ml) had no impact on human oral keratinocytes, but exerted growth inhibitory effects on HSC-3 cancer cells, which were increased in the presence of LGG. Flow cytometric analysis anda nuclear staining assay with DAPI revealed that HSC-3 cancer cells treated with LGG-geniposide (1.010(3) CFU/ml LGG and 50 g/ml geniposide) had a higher apoptotic rate than cells in other treatment groups, particularly that treated with geniposide (50 g/ml) only. Geniposide also increased themRNA and protein expression of caspase-3, -8 and -9 as well as B-cell lymphoma 2 (Bcl-2)-associated X protein, p53, p21, inhibitor of nuclear factor-B (NF-B) , Fas and Fas ligand, while decreasing Bcl-2, Bcl extra large protein, inhibitor of apoptosis-1 and -2, NF-B, cyclooxigenase-2 and inducible nitric oxide synthase in HSC-3 cells, which was increased in the presence of LGG. These results indicated that LGG enhanced the anticancer effects of geniposide in HSC-3 cells.

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Thanksgiving? A Day of Despair for Many Because of Crimes Against Humanity "IndyWatch Feed Health"

Woundedknee 1891

Burial of the dead after the massacre of Wounded Knee. U.S. Soldiers putting Indians in common grave; some corpses are frozen in different positions. South Dakota. Published Jan. 17 1891 by Northwestern Photo Co.

by Brian Shilhavy
Editor, Health Impact News

Today is a holiday of Thanksgiving for many people in the United States.

While I do not want to ruin the day for those who are truly thankful for blessings in their lives, especially if the thanks is directed towards God and his grace extended to mankind (In everything give thanks; for this is Gods will for you in Christ Jesus. 1 Thessalonians 5:18), I think it is important to understand that this is not a day of Thanksgiving for many people, but a day of mourning.

Dr. Gary Kohl has reminded us that Native Americans are not fond of Thanksgiving. Here is the text of a plaque that overlooks Plymouth Rock, the site where Puritans first landed on Native American soil that explains why Thanksgiving has only negative connotations for non-whites:

Since 1970, Native Americans have gathered at noon on Coles Hill in Plymouth to commemorate a National Day of Mourning on the US Thanksgiving holiday.

Many Native Americans do not celebrate the arrival of the Pilgrims and other European settlers.

To them, Thanksgiving Day is a reminder of the genocide of millions of their people, the theft of their lands, and the relentless assault on their culture.

Participants in a National Day of Mourning honor Native ancestors and the struggles of Native peoples to survive today. It is a day of remembrance and spiritual connection as well as a protest of the racism and oppression which Native Americans continue to experience.



Lactobacillus rhamnosus GG effectively supresses bone loss in a mouse model of induced periodontitis irrespective of the mode of administration. "IndyWatch Feed Health"

PMID:  J Clin Periodontol. 2017 Nov 9. Epub 2017 Nov 9. PMID: 29121411 Abstract Title:  Probiotic Lactobacillus rhamnosus GG prevents alveolar bone loss in a mouse model of experimental periodontitis. Abstract:  AIM: This study investigated the role of Lactobacillus rhamnosus GG on bone loss and local and systemic inflammation in an in vivo mouse model of experimental periodontitis.MATERIALS AND METHODS: Experimental periodontitis was induced in mice by oral inoculation with Porphyromonas gingivalis and Fusobacterium nucleatum over a period of 44 days. The probiotic LGG was administered via oral inoculation or oral gavage prior to, and during disease induction. The antimicrobial activity of LGG on the inoculum was also tested. Alveolar bone levels and gingival tissue changes were assessed using in vivo micro-computed tomography and histological analysis. Serum levels of mouse homologues for IL-8 were measured using multiplex assays.RESULTS: Pre-treatment with probiotics either via oral gavage or via oral inoculation significantly reduced bone loss (p

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MCH Blood Test: What Do MCH Levels in Blood Mean? (Evidence Based) "IndyWatch Feed Health"

MCH blood test is usually done as part of a complete blood count (CBC) test that doctors use to check your general health. MCH stands for mean corpuscular hemoglobin and is the amount of hemoglobin in your red blood cells. Hemoglobin is the protein molecule in red blood cells that carries oxygen from the lungs to the bodys tissues and returns carbon dioxide from the tissues back to the lungs. Some of the causes of abnormal MCH levels are iron deficiency, lack of vitamin B12, thyroid issues, or problems with your liver function.

Normal MCH levels mean that your body is producing enough hemoglobin. This also means that there are no underlying medical conditions that are causing hemoglobin to get destroyed too quickly.

Having low or high levels of hemoglobin can tell if you have different types of anemia. If your complete blood test count test shows that you have anemia and abnormal MCH levels, you might also feel fatigued, have a rapid heartbeat, palpitations, and difficulty concentrating.

This article looks at what your MCH blood test means and what it tells about your health. You will also find out what to do if you have low mean corpuscular hemoglobin levels (low MCH).

What is MCH Blood Test?

Hemoglobin is an important molecule in your red blood cells that helps to carry oxygen to body tissues. The MCH is a calculation of the average amount of hemoglobin inside a single red blood cell.

The only way that doctors can test MCH levels in a lab test is to use it as part of a complete blood count (CBC). Dr. Brian Yang Merritt on Medscape says that MCH results are derived from measuring the concentration of hemoglobin in your red blood cell count (RBC).1

The MCH blood test is also related to the MCHC blood test which measures the concentration of hemoglobin in a given volume of red blood cells. Together, the MCH and MCHC indices are used to help doctors determine the cause of certain medical conditions.

What is CBC blood test?

A CBC (complete blood count) is a panel of tests that evaluates the three types of cells that circulate in the blood:

  • White blood cells
  • Red blood cells
  • Platelets

According to doctors from the Mayo Clinic, the CBC blood test is used to assess your general health. The CBC can then be used by doctors to diagnose a variety of disorders including infections, anemia, and leukemia. The CBC tests for abnormalities in red blood cells, white blood cells, hemoglobin, plasma, and platelets.2

What Are Normal MCH Levels?...


100 Million Homes in America Contain a Deadly Fiber That Could Turn into Cancer "IndyWatch Feed Health"

The Mesothelioma + Asbestos Awareness Center is dedicated to raising asbestos and mesothelioma cancer awareness. Visit their website and follow on Facebook.   Approximately eighty percent of homes built prior to 1980 contain asbestos. Considering the approximate 125 million households in the United States, thats about 100 million homes, that each contains the potential of... View Article

The post 100 Million Homes in America Contain a Deadly Fiber That Could Turn into Cancer appeared first on Healthy Holistic Living.


L. paracasei Jlus66 has great potential as a probiotic in protecting from NAFLD. "IndyWatch Feed Health"

PMID:  Food Funct. 2017 Nov 6. Epub 2017 Nov 6. PMID: 29106426 Abstract Title:  Effect of a novel potential probiotic Lactobacillus paracasei Jlus66 isolated from fermented milk on nonalcoholic fatty liver in rats. Abstract:  Nonalcoholic fatty liver disease (NAFLD) is the main cause of chronic liver disease worldwide. Previous evidence indicates that probiotics can be applied as a therapeutic agent for NAFLD. In this study, the potential probiotic strain Lactobacillus paracasei Jlus66 was isolated from natural fermented milk by a culture-dependent method, and its probiotic potentials were tested by established in vitro tests. In addition, the protective effect of Lactobacillus paracasei Jlus66 against NAFLD was evaluated in rat models. Compared with the high-fat-diet (HFD) group, the rats administered with 4 10(10) cfu Jlus66 had significantly lower body weight gain, serum triglyceride (TG), low-density lipoprotein (LDL) as well as aminotransferase (ALT). Histopathological analysis showed Jlus66 also reduced the level of hepatic triglycerides and steatosis. From the above we conclude that L. paracasei Jlus66 has great potential as a probiotic in protecting from NAFLD.

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Lactobacillus strains attenuate Salmonella Enteritidis, Heidelberg and Typhimurium colonization and virulence gene expression in vitro. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2017 Nov 9 ;18(11). Epub 2017 Nov 9. PMID: 29120368 Abstract Title:  Lactobacillus bulgaricus, Lactobacillus rhamnosus and Lactobacillus paracasei Attenuate Salmonella Enteritidis, Salmonella Heidelberg and Salmonella Typhimurium Colonization and Virulence Gene Expression In Vitro. Abstract:  Salmonella Enteritidis (SE), Salmonella Typhimurium (ST), and Salmonella Heidelberg (SH) have been responsible for numerous outbreaks associated with the consumption of poultry meat and eggs. Salmonella colonization in chicken is characterized by initial attachment to the cecal epithelial cells (CEC) followed by dissemination to the liver, spleen, and oviduct. Since cecal colonization is critical to Salmonella transmission along the food chain continuum, reducing this intestinal association could potentially decrease poultry meat and egg contamination. Hence, this study investigated the efficacy of Lactobacillus delbreuckii sub species bulgaricus (NRRL B548; LD), Lactobacillus paracasei (DUP-13076; LP), and Lactobacillus rhamnosus (NRRL B442; LR) in reducing SE, ST, and SH colonization in CEC and survival in chicken macrophages. Additionally, their effect on expression of Salmonella virulence genes essential for cecal colonization and survival in macrophages was evaluated. All three probiotics significantly reduced Salmonella adhesion and invasion in CEC and survival in chicken macrophages (p

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Home Remedies for Migraines and Headaches "IndyWatch Feed Health"

For everyone who has had a migraine, you know how painful they are. They are much more severe and last longer than regular headaches.  At the first sign of symptoms, such as vision loss or a pins and needles feeling,  you know its time to do something before the intolerable pain comes.  Many people turn... View Article

The post Home Remedies for Migraines and Headaches appeared first on Healthy Holistic Living.


The results confirmed that lactic acid bacteria are a promising strategy to control food contamination of fermented food and dairy products. "IndyWatch Feed Health"

PMID:  Probiotics Antimicrob Proteins. 2017 Nov 18. Epub 2017 Nov 18. PMID: 29150754 Abstract Title:  Detoxification of Aflatoxin B1 by Antifungal Compounds from Lactobacillus brevis and Lactobacillus paracasei, Isolated from Dairy Products. Abstract:  Aflatoxins are a large group of highly toxic, mutagenic, and carcinogenic mycotoxins produced by specific species of fungi. Potential contamination of food commodities by these compounds causes extensive damage that lead to great economic losses. This study explored the potential use of antifungal compounds, produced by Lactobacillus brevis and Lactobacillus paracasei, for growth inhibition and subsequent aflatoxin B1 production from select strains of Aspergillus flavus and Aspergillus parasiticus. Lactobacilli strains were isolated from traditional Egyptian dairy products, whereas fungal strains were isolated from infected cereal seeds. There were noticeable decreases in mycelium biomass and aflatoxin production as well. L. brevis exhibited the highest reduction of aflatoxin B1 production by A. flavus and A. parasiticus, 96.31 and 90.43%, respectively. The concentrations of amino acids of the antifungal compound produced by L. brevis were significantly higher than that produced by L. paracasei. Asparagine, glutamine, glycine, alanine, and leucine were the most concentrated amino acids for both strains. The antifungal compounds produced by L. brevis and L. paracasei were active in a wide range of pH, heat stable and inactivated by proteolytic enzymes (protease K and trypsin A). The expression of Omt-A gene that involved in the later step of aflatoxin production was evaluated by real-time PCR. There was a vigorous reduction at transcriptional level of Omt-A gene observed in A. flavus that is treated by L. brevis and L. paracasei (80 and 70%, respectively). However, the reduction of Omt-A gene observed in A. parasiticus that is treated by L. brevis and L. paracasei was 64.5 and 52%, respectively. Treating maize seeds with antifungal compounds exhibited great efficiency in controlling fungal infection and increasing seed germination. The results confirmed that lactic acid bacteria are a promising strategy to control food contamination of fermented food and dairy products.

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Lactobacillus paracasei feeding improves immune control of influenza infection in mice. "IndyWatch Feed Health"

PMID:  PLoS One. 2017 ;12(9):e0184976. Epub 2017 Sep 20. PMID: 28931041 Abstract Title:  Lactobacillus paracasei feeding improves immune control of influenza infection in mice. Abstract:  Respiratory tract infections such as flu cause severe morbidity and mortality and are among the leading causes of death in children and adults worldwide. Commensal microbiota is critical for orchestrating tissue homeostasis and immunity in the intestine. Probiotics represent an interesting source of immune modulators and several clinical studies have addressed the potential beneficial effects of probiotics against respiratory infections. Therefore, we have investigated the mechanisms of protection conferred by L. paracasei CNCM I-1518 strain in a mouse model of influenza infection. Notably, local myeloid cells accumulation is generated in the lungs after seven days feeding with L. paracasei prior to viral infection. L. paracasei-fed mice showed reduced susceptibility to the influenza infection, associated with less accumulation of inflammatory cells in the lungs, faster viral clearance and general health improvement. Interestingly, Allobaculum was significantly increased in L. paracasei-fed mice 7 days after influenza infection, even if the gut microbiota composition was not altered overall. L. paracasei-purified peptidoglycan partially recapitulated the protective phenotype observed with the entire bacteria. Collectively, our results demonstrate that oral consumption of L. paracasei CNCM I-1518 modulates lung immunity was associated with an improved control of influenza infection. These results further extend the beneficial role for certain lactobacilli to alleviate the burden of respiratory tract infections.

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Certain Lactobacillus species can effectively augment antiviral responses in chicken macrophages. "IndyWatch Feed Health"

PMID:  Res Vet Sci. 2017 Oct 31. Epub 2017 Oct 31. PMID: 29132684 Abstract Title:  Interactions between lactobacilli and chicken macrophages induce antiviral responses against avian influenza virus. Abstract:  Macrophages are an important cell type of the innate immune system that upon activation, can exert antiviral functions and also can induce virus-specific adaptive immune responses. Macrophage interaction with certain probiotic bacteria such as lactobacilli can enhance antiviral functions of these cells. We have previously shown that administration of lactobacilli to chickens can effectively augment immune response to vaccine antigens. Here, we investigated the effects of representative strains of three Lactobacillus species, L. acidophilus, L. reuteri and L. salivarius used alone or in combination, in enhancing antiviral activity of chicken macrophages against avian influenza virus in an in vitro model using MQ-NCSU cells. Treatment of macrophages with probiotic lactobacilli significantly enhanced the antiviral functions, as determined by the virus titration assay. We also found that lactobacilli stimulation of macrophages induced significantly higher expression of interleukin (IL)-1, interferon (IFN)- and IFN- cytokine genes as well as interferon regulatory factor-7 (IRF7), 2',5'-oligoadenylate synthetase (OAS) and interferon-inducible transmembrane protein M3 (IFITM3) genes. Furthermore, macrophages that were treated with lactobacilli had significantly enhanced production of nitric oxide (NO) and IFN- protein as well as surface expression of the costimulatory molecule CD40. However, the antiviral and immunostimulatory effects of probiotic lactobacilli largely depended on the Lactobacillus species studied. Collectively, the results from our study using an in vitro model showed that certain Lactobacillus species can effectively augment antiviral responses in chicken macrophages.

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Lactobacillus plantarum HNU082-derived improvements in the intestinal microbiome prevent the development of hyperlipidaemia. "IndyWatch Feed Health"

PMID:  Food Funct. 2017 Nov 2. Epub 2017 Nov 2. PMID: 29094115 Abstract Title:  Lactobacillus plantarum HNU082-derived improvements in the intestinal microbiome prevent the development of hyperlipidaemia. Abstract:  Restricted by research techniques, the probiotic-derived changes in the microbiome and microbial metabolites correlated with the potential prevention of hyperlipidaemia have remained undiscovered. In the present research, a metagenomic approach was applied to describe Lactobacillus plantarum HNU082 consumption-derived changes in the intestinal microbiome and their correlation with the occurrence and development of hyperlipidaemia. Principal coordinate analysis based on UniFrac distances indicated that the intestinal microbiota was profoundly altered in the hyperlipidaemia group, and probiotic consumption regulated the bias in the intestinal microbial structure in hyperlipidaemia. Bifidobacterium, Lactobacillus, Akkermansia and Faecalibacterium were significantly increased in the probiotic group, and the genera Clostridium, Natranaerovirga and Odoribacter were significantly increased in the hyperlipidaemia group. Further analysis based on metabolic pathways revealed that pyruvate metabolism, glycerolipid metabolism, propanoate metabolism, and fatty acid biosynthesis were enriched in the probiotic and control groups. In contrast, the pathways of secondary bile acid and lipopolysaccharide biosynthesis were enriched in the hyperlipidaemia group. Finally, we constructed a network to better explain the potential mechanism of hyperlipidaemia prevention. The present basic research will promote our understanding of the probiotic action mechanism in hyperlipidaemia therapy and provide new insight into the design and application of probiotic-containing functional foods.

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Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on birch pollen induced allergic rhinitis. "IndyWatch Feed Health"

PMID:  J Appl Microbiol. 2017 Nov 12. Epub 2017 Nov 12. PMID: 29130606 Abstract Title:  Oral administration of Lactobacillus plantarum CJLP133 and CJLP243 alleviates birch pollen induced allergic rhinitis in mice. Abstract:  AIMS: In this study, we evaluated the therapeutic efficacy of selected probiotics in a mouse model of birch pollen (BP)-induced allergic rhinitis.METHODS AND RESULTS: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 ameliorated the symptoms of BP-induced allergic rhinitis by reducing airway hyperresponsiveness (AHR), and both the histological scores and the number of infiltrated cells in the nasal cavities and lungs. Compared with those from vehicle-treated mice, bronchoalveolar lavage (BAL) fluid and draining lymph node samples from CJLP133 and CJLP243-administrated mice showed diminished numbers of immune cells, increased secretion of a Th1-type cytokine (IFN-), and decreased production of Th2-type cytokines (IL-4, IL-5 and IL-13). Consistent with these results, levels of IL-4, IL-5, IL-13, serum IgE, and BP-specific serum IgG1 were decreased, whereas secretion of IFN- and BP-specific serum IgG2a were augmented upon administration of CJLP133 and CJLP243 in mice.CONCLUSION: Oral administration of lactobacillus plantarum CJLP133 and CJLP243 alleviates symptoms of BP-induced allergic rhinitis in mice by recovering Th1/Th2 balance via enhancement of the Th1-type immune response.SIGNIFICANCE AND IMPACT OF THE STUDY: Lactobacillus plantarum CJLP133 and CJLP243 have therapeutic effects on BP-induced allergic rhinitis in an animal model. This article is protected by copyright. All rights reserved.

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50 Workers Just Fired From Health System For Refusing Vaccines "IndyWatch Feed Health"

By Heather CallaghanEditor

And so it begins A healthcare system has literally fired 50 employees in one fell swoop  over a draconian flu jab policy

They cant fire us all if we stand up, right? That might be the inner wishful thinking of those who refuse vaccinations while working in the healthcare system.

But as WGN9 reports:

A Minnesota-based health system has fired about 50 employees who refused to get a flu shot.

Essentia Health announced last month that employees would be required to get vaccinated for influenza unless they received a religious or medical exemption.

The system claimed that it was trying to keep patients from getting sick at its 15 hospitals and 75 clinics in Minnesota, Idaho, North Dakota and Wisconsin.

From WGN9:

Essentia says 99 percent of the companys 13,900 eligible employees had gotten the shot, received an exemption or were gett...


Fight Against Last Weeks FDA Warning and What It Means to the Kratom Community "IndyWatch Feed Health"

Last week, the FDA dropped the other shoe to ban kratom that we all knew was coming.Faceless bureaucrats at the Food and Drug Administration told the new FDA Commissioner, Scott Gottlieb, to issue a Public Health Advisory on kratom, justified by outright LIES that kratom carries similar risks as opiates, including addiction and death, and other mischaracterized scientific claims.

Major media outlets such as CNN, CBS News, NBC, NPR, Fox News and others picked up on the advisory, further spreading the FDAs liesall part of their campaign to threaten our hard work to keep kratom legal and available to you.The most troubling coverage of the FDA Advisory came in the form of a CNBC interview with FDA Commissioner Dr. Scott Gottlieb,who lied on air and described kratom is an opioid analogue, setting the stage to include kratom as a banned substance in the SITSA (Stop the Importation and Trafficking of Synthetic Analogues) Bill.

SITSA, if passed, would give Attorney General Jeff Sessions unchecked authority to ban any substance without any medical or scientific review; for a temporary period of FIVE YEARS, and exempt from a judicial or legislative challenge during that span.


AKA was criticized for causing a panic by some in the kratom industry for coming out strong against SITSA, arguing the bill wouldnt impact kratom given that it is not an analogue of an opioid.

but we kept up the fight,...


Essentia Health Fires Flu Shot Refusing Nurses "IndyWatch Feed Health"

Its done. 69 employees have been fired from Minnesota based health company, Essentia Health, for not complying with mandatory flu shot rules. As we first reported last week, many nurses and employees were absolutely refusing...

The post Essentia Health Fires Flu Shot Refusing Nurses appeared first on Vaxxter.


Caught Our Notice: When authors go MIA, the article may follow "IndyWatch Feed Health"

Title: IRF9 inhibits human acute myeloid leukemia through the SIRT1-p53 signaling pathway What Caught Our Attention: When authors fail to respond to editors requests for information, it isnt hard to imagine that the submitted manuscript will lose its publishing appeal. In this case, the journal and publisher withdrew the article after repeated attempts to contact the authors []

The post Caught Our Notice: When authors go MIA, the article may follow appeared first on Retraction Watch.


How to Cope With Social Anxiety Over Thanksgiving "IndyWatch Feed Health"

In this piece for Medical News Today, Jasmin Collier describes five non drug-related ways to cope with social anxiety over the Thanksgiving holiday: preparing in advance, having a job to do, turning anxiety into excitement, being curious, and giving yourself permission to step back and take a break.


4 Reasons Gratitude is Good for You "IndyWatch Feed Health"

From USA Today: Gratitude has been shown to have both physical and mental health benefits. Here are a few ways to cultivate our feelings of gratitude and express appreciation more often.

Research suggests that individuals who feel grateful experience lower blood pressure, improved immune functions, recover more quickly from illness, and can more effectively cope with stress, explains Shilagh Mirgain, PhD, a health psychologist with UW Health (University of Wisconsin).

Gratitude has one of the strongest links to mental health, more so than even optimism. And the benefits can be life-long. A sense of gratitude can reduce the lifetime risk for depression, anxiety and even substance abuse disorders.



Us, Too: Sexual Violence Against People Labeled Mentally Ill "IndyWatch Feed Health"

In light of the recent events and media discussions pertaining to the issue of sexual violence, we feel that it is of the utmost importance to speak out about this issue in the context of psychiatry and the treatment of those perceived as mentally ill. As victims of psychiatric coercion, we wanted to share some of the sexual violations and abuses we experienced in the name of medical treatment, such as forced catheterization, being watched while showering, and legal sexual assault.


Rudys Story

I have been forcibly hospitalized three times. The first time was while serving in the army in 2009, and the second and third times were in 2014 about a month apart. All of these hospitalizations were traumatizing for a variety of reasons, but the third time was by far the worst.

In 2014, I was in community college and was experiencing a great deal of stress due to pushing myself too hard. As a 26-year-old college student, I felt like a failure for having taken so long to begin college. I also felt ashamed of having a mental health diagnosis and being discharged from the army for that reason. I never felt like I quite fit in with my classmates or with students taking part in the extracurricular activities I participated in, such as my theater group. I was scared that I would never fit in or be normal.

One day, as I was driving to rehearsal for my theater group, I began to panic. I felt intense anxiety due to not being able to learn my lines as a result of the psychiatric medications I was taking. When I arrived at the theater, I became catatonic. The director called the ambulance, and I was put in restraints and taken to the emergency room. Although I was only in the emergency room for a few hours, the experience felt traumatizing and further isolated me from my peers.

Wanting to put that experience behind me, I continued with school and theater. However, the pressure kept building up. I started to feel like I couldnt handle it, and I didnt see a solution. I did not wish to drop out of school, but I also could not see myself making it to the end of the semester.

One day, just a few hours before rehearsal, I isolated myself in my room, hiding under my covers, feeling like everything in the outside world was just too much. A friend came to check on me, and I was unresponsive. My friend then called my roommate, who called the police.

Before I could fully grasp what was going on, the paramedics arrived at my apartment. Because I was catatonic and unable to respond, they put me on a stretcher in four-point restraints and took me to the emergency room. The whole ride, I felt terrified, not knowing what would happen next. Eventually, I regained my ability to speak and begged the paramedics to take me...


We're Thankful for You! Age of Autism Donor Matching Gift Program. "IndyWatch Feed Health"

November is here, Giving thanks is due. Im donating to AoA, How about you? Thanksgiving is today, and a perfect time to express our gratitude for this wonderful forum we know as the Age of Autism blog. Please take a...

Happy Thanksgiving from Age of Autism "IndyWatch Feed Health"

Dear friends, readers, families, colleagues and supporters, we at AofA would like to wish you each a very happy Thanksgiving. We are grateful for your readership, your likes, links, reTweets and comments throughout the year. The winds change, and we...


New Genetically Modified Tomatoes May Soon Hit The Marketplace "IndyWatch Feed Health"

Tomatoes were one of the first commercially available genetically modified (GM) crops ever. GM tomatoes are about to make a comeback in 2018 as Chinese and French researchers reveal details of how they genetically-engineered tomatoes to boost vitamins and other nutrients.


Members of the Australian Dental Association visit Gunnedah to brief Gunnedah Shire Council about adding fluoride to the water supply "IndyWatch Feed Health"

Gunnedah Shire Councillors attended a closed meeting on Wednesday to be briefed by members of the Australian Dental Association (ADA) NSW regarding water fluoridation.

ADA spokeswoman Dr Sarah Raphael, who hosted the briefing, shared with councillors and local dentists a report from the federal governments National Health and Medical Research Council on water fluoridation.

Dr Raphael said water fluoridation has been researched in Australia for decades.

Water fluoridation is one of the most widely-studied public health measures of all time, Dr Raphael said.

Decades of research in Australia have proven it is safe and effective in preventing tooth decay, water fluoridation gives everyone in the community protection from tooth decay on tap.

The fluoride debate has prompted a wave of facebook groups against water fluoridation, including a group administrated by Gunnedahs Wendy Carpenter called Its OK to say NO to fluoride in Gunnedahs water.

Mrs Carpenter said the group is designed to help bring balance to the discussion.

There are a growing number of people in our community who are very concerned about the proposed fluoridation of Gunnedahs water, Mrs Carpenter said.

We are very concerned that in the light of increasing evidence that ingesting fluoride in water is not safe nor is it the most effective method of tooth protection.

Fluoride Action Network Australia (FANA) chair Merilyn Haines said the organisation has sent research and reports to council and hopes council will consider research from both sides of the debate.

We hope that Councillors will consider these concerns because NSW Health will not be providing this type of information either to the Councillors, or to the public in the very one sided biased consultation that NSW Health is conducting, Mrs Haynes said.

Gunnedah dentist Dr Karthikeyan Muthusamy supports water fluoridation and said adding fluoride to the water is safe for everyone.

I strongly recommend fluoridation, Dr Muthusamy said.

It comes from a solid basis of research and it saves people a lot of trouble in regards to dental health.

The briefing follows a resolution from the October ordinary council meeting that stated NSW Health would seek public feedback regarding fluoridation and report the findings to council at Decembers ordinary council meeting.

*Original article online at...


Bill to protect fluoridation from politics "IndyWatch Feed Health"

The new chair of parliaments health select committee is looking forward to making progress on some major pieces of legislation.

Louisa Wall says the committee tends to set aside party political interests as memberrs strive for a health system that works for all New Zealanders.

On the table is a government bill that will make district health boards rather than local government responsible for fluoridating water supplies.

Its an issue that has become increasingly heated in recent years as anti-fluoridation groups target local councils.

The intent of this piece of legislation is to take it out of the hands of a political process and allow DHBs to lead about whether or not we should have fluoride in our water, whose main purpose is to help prevent tooth decay, Ms Wall says.

Also on the agenda is a private bill to ensure babies are assigned to a public health organisation with the responsibility of making sure they receive all their immunisations, and its also likely there will be bills on medical cannabis and assisted dying.


*Original article online at



Happy Thanksgiving! "IndyWatch Feed Health"

Happy Thanksgiving to our American readers, and to everyone else- have a great Thursday in November!

Happy Thanksgiving! "IndyWatch Feed Health"

Happy Thanksgiving to our American readers, and to everyone else- have a great Thursday in November!


Tarragon Adds a French Twist to Your Meals "IndyWatch Feed Health"

Tarragon (pronounced TEHR-uh-gon) or Artemisia dracunculus is an herb that is popular in the world of cooking. In fact, tarragon is such a vital part of French cuisine that it is one of the "Fines Herbes." These are the four most commonly used herbs in French cuisine, which also includes parsley, chervil and chives.1 Tarragon is known for its slightly bittersweet flavor, with an aroma similar to anise.2

The earliest records of tarragon date back to more than 600 years ago. It was believed to have been introduced to Italy in the 10th century during the time of the Mongol invasions. The Mongolians used tarragon as a sleep aid, breath freshener and seasoning.

After this turbulent period, some tarragon histories have St. Catherine of Siena bringing tarragon back to France after a visit with Pope Clement VI.3 However, she could not have done this as she was only 5 years old when Clement VI4 died. While other histories have tarragon arriving in France in the 1500s, if St. Catherine was the one who brought it to France, most likely it was after her visit to see Pope Gregory VI in 1376.5

The Different Health Benefits of Tarragon

Tarragon contains various nutrients and essential oils that can provide a multitude of benefits. The most well-known ones include:

Pain Relief

Chewing the leaves can help relieve pain, especially in the mouth or tooth. You can consume tarragon tea to get the same benefit.

Induce Sleep

Drinking tarragon tea can help those with insomnia. The calming effect of the herb's compounds can help you rest well at night.

Increase Appetite


How to Increase Your Sense of Gratitude "IndyWatch Feed Health"

By Dr. Mercola

Thanksgiving celebrated each year on the fourth Thursday of November is perhaps one of the most cherished of American holidays; it's a time when family and friends gather over ample amounts of food and give thanks for the blessings in life, including each other. As explained by University of California psychology professor Robert Emmons, one of the leading scientific experts on gratitude and author of several books on the topic, gratitude involves two key components:1

  1. It's "an affirmation of goodness;" when you feel gratitude, you affirm that you live in a benevolent world
  2. It's a recognition that the source of this goodness comes from outside of yourself; that other people (or higher powers, if you prefer) have provided you with "gifts" that improve your life in some way

An Attitude of Gratitude Fosters Health and Happiness

The practice of openly sharing what we're grateful for is by many accounts one of the healthiest aspects of our annual Thanksgiving festivity. According to psychologists, it's a ritual that fosters both happiness and health. It's unfortunate that most people reserve this gratitude ritual for Thanksgiving Day only. While giving thanks once a year is beneficial, doing it more often could be life changing.2 At least that's what science suggests.

Studies have actually shown that the psychological state of gratitude has beneficial implications for every major organ system in your body.3 So, if you're serious about your well-being you'd be wise to increase the frequency at which you feel and express gratitude. Adopting the ritual of saying grace at every meal, for example, is a great way to flex your gratitude muscle on a daily basis,4 and will also foster a deeper connection to your food.

When you reflect on all the things that went into its creation, from the sowing of the seed, to the harvest and the cooking, you'll realize just how much work by both nature and man went into creating the meal before you that will now provide you with nourishment. Considering a breakdown anywhere along that chain would result in scarcity and hunger, the...

The Science of Seasonal Affective Disorder (SAD) "IndyWatch Feed Health"

By Dr. Mercola

Seasonal affective disorder (SAD) is a form of depression that occurs seasonally, typically ramping up in the fall and winter months and disappearing come spring (although it may occur during other seasons as well, albeit less often). Its quite common for people to notice changes in their mood, energy levels and food cravings when the weather turns colder and the days get shorter, but this slump, known as winter blues, is different from true SAD.

In the case of SAD, symptoms are so severe that they interfere with daily life. "I feel myself wanting to cry for no reason; I overreact extensively and am extremely irritable," one SAD sufferer told NBC News.1 There are days where I cannot bring myself to get out of bed or function.

Common SAD symptoms include oversleeping, intense carbohydrate cravings, overeating and weight gain. Some people also have trouble concentrating and withdraw socially,2 preferring to hibernate indoors instead of carrying on with their normal day-to-day activities.

Dr. Norman Rosenthal, clinical professor of psychiatry at Georgetown University School of Medicine, was the first to describe SAD, writing in a 1984 journal article that the depressions were generally characterized by hypersomnia, overeating and carbohydrate craving, and seemed to respond to changes in climate and latitude.3 Indeed, rates of SAD vary depending on location, with people living farthest from the equator in northern latitudes being most susceptible.

In the U.S., for instance, according to a review published in Depression Research and Treatment, SAD affects only 1 percent of Floridians compared to 9 percent of Alaskans.4 Women are also at increased risk, with SAD being diagnosed four times more often in women than men. Young adults also seem to be disproportionately affected (SAD typically begins between the ages of 18 and 30 years),5 and this could be due to links to ancient ancestors. Professor Robert Levitan of the University of Toronto told The Guardian:6



Lactobacillus plantarum help protect the integrity of intestinal epithelial cell barrier damaged by enterotoxigenic Escherichia coli. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2017 Nov 13 ;18(11). Epub 2017 Nov 13. PMID: 29137183 Abstract Title:  Lactobacillus plantarum Enhanced IL-22 Production in Natural Killer (NK) Cells That Protect the Integrity of Intestinal Epithelial Cell Barrier Damaged by Enterotoxigenic Escherichia coli. Abstract:  Interleukin (IL)-22-producing Natural Killer (NK) cells protect the gut epithelial cell barrier from pathogens. A strain of probiotics, Lactobacillus plantarum (L. plantarum, LP), was previously found by our laboratory to significantly improve the mucosal barrier integrity and function of the small intestine in pigs. However, it was unclear whether LP benefited the intestinal mucosal barrier via interactions with the intestinal NK cells. The present study, therefore, was focused on the therapeutic effect of NK cells that were stimulated by LP on attenuating enterotoxigenic Escherichia coli (ETEC)-induced the damage to the integrity of the epithelial cell barrier. The results showed that LP can efficiently increase protein levels of the natural cytotoxicity receptor (NCR) family, and the expression levels of IL-22 mRNA and protein in NK cells. Transfer of NK cells stimulated by LP conferred protection against ETEC K88-induced intestinal epithelial barrier damage in NCM460 cells. We found that NK cells stimulated by LP could partially offset the reduction in NCM460 cell monolayers transepithelial electrical resistance (TEER) caused by ETEC K88, and increase ZO-1 and occludin mRNA and protein expressions by ETEC K88-infected NCM460 cells. Furthermore, adding NK cells that were stimulated by LP to ETEC K88-infected NCM460cells, IL-22R1, p-Stat3, and p-Tyk2 expression by NCM460 cells was increased. Mechanistic experiment showed that NK cells stimulated by LP lost the function of maintaining TEER of NCM460 cells challenged with ETEC K88, when polyclonal anti-IL-22 antibody was used to block IL-22 production. Collectively, our results suggested that LP stimulation of NK could enhance IL-22 production, which might be able to provide defense against ETEC-induced damage to the integrity of intestinal epithelial barrier.

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Immune-enhancing effect of nanometric Lactobacillus plantarum nF1 in a mouse model of cyclophosphamide-induced immunosuppression. "IndyWatch Feed Health"

PMID:  J Microbiol Biotechnol. 2017 Nov 15. Epub 2017 Nov 15. PMID: 29141128 Abstract Title:  Immune-enhancing effect of nanometric Lactobacillus plantarum nF1 (nLp-nF1) in a mouse model of cyclophosphamide-induced immunosuppression. Abstract:  Nanometric Lactobacillus plantarum nF1 (nLp-nF1) is a biogenics consisting of dead L. plantarum pre-treated with heat and a nanodispersion process. In this study, we investigated the immune-enhancing effects of nLp-nF1 in vivo and in vitro. To evaluate the immunostimulatory effects of nLp-nF1, mice immunosuppressed by cyclophosphamide (CPP) treatment were administered with nLp-nF1. As expected, CPP restricted the immune response of mice, whereas oral administration of nLp-nF1 significantly increased total IgG in serum, and cytokine production [interleukin-12 (IL-12) and tumor necrosis factor alpha (TNF-)] in bone marrow cells. Furthermore, nLp-nF1 enhanced the production of splenic cytokines such as IL-12, TNF-, and interferon gamma (IFN-). In vitro, nLp-nF1 stimulated the immune response by enhancing the production of cytokines such as IL-12, TNF-, and IFN-. Moreover, nLp-nF1 given a food additive enhanced the immune responses when combined with various food materials on in vitro. These results suggest that nLp-nF1 could be used to strengthen the immune system and recover normal immunity in people with a weaker immune system, such as children, the elderly, and patients.

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Lactobacillus plantarum induces apoptosis in oral cancer KB cells. "IndyWatch Feed Health"

PMID:  Bioimpacts. 2017 ;7(3):193-198. Epub 2017 Jun 7. PMID: 29159146 Abstract Title:  Lactobacillus plantarum induces apoptosis in oral cancer KB cells through upregulation of PTEN and downregulation of MAPK signalling pathways. Abstract:  Introduction: The oral tumor is the sixth most prevalent type of cancer worldwide and the second leading cause of cancer-related mortality. Although chemotherapy and immunotherapy are the main strategies for the treatment of oral cancer, an emergence of inevitable resistance to these treatment modalities is the major drawback that causes recurrence of the disease. Nowadays, probiotics have been suggested as adjunctive and complementary treatment modalities for improving the impacts of chemotherapy and immunotherapy agents. Probiotics, the friendly microflora in our bodies, contribute to the production of useful metabolites with positive effects on the immune system against various diseases such as cancer. Methods:Lactobacillus plantarum is one of the most important bacteria, which commensally live in the human oral system. In the current study, the impacts of L. plantarum on maintaining oral system health were investigated, and the molecular mechanisms of inhibition of oral cancer KB cells mediated by L. plantarum were evaluated using real-time polymerase chain reaction (PCR) and FACS flow cytometry analyses. Results: Our findings showed that L. plantarum is effective in the signal transduction of the oral cancer cells through upregulation and downregulation of PTEN and MAPK pathways, respectively. Conclusion: Based on the biological effects of oral candidate probiotics candidate bacterium L. plantarum on functional expression of PTEN and MAPK pathways, this microorganism seems to play a key role in controlling undesired cancer development in the oral system. Taken all, L. plantarum is proposed as a potential candidate for probiotics cancer therapy.

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Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects. "IndyWatch Feed Health"

PMID:  Nutrients. 2017 Nov 21 ;9(11). Epub 2017 Nov 21. PMID: 29160817 Abstract Title:  Impact of High-Dose Multi-Strain Probiotic Supplementation on Neurocognitive Performance and Central Nervous System Immune Activation of HIV-1 Infected Individuals. Abstract:  BACKGROUND: Gut microbiota has metabolic activity which influences mucosal homeostasis, local and systemic immune responses, and other anatomical systems (i.e., brain). The effects of dysbiosis are still poorly studied in Human Immunodeficiency Virus-1 (HIV-1) positive subjects and insufficient data are available on the impairment of the gut-brain axis, despite neurocognitive disorders being commonly diagnosed in these patients. This study evaluated the impact of a probiotic supplementation strategy on intrathecal immune activation and cognitive performance in combined antiretroviral therapy (cART) treated HIV-1 infected subjects.METHODS: Thirty-five HIV-1 infected individuals were included in this study. At baseline (T0) a battery of tests was administered, to evaluate neurocognitive function and a lumbar puncture was performed to determine neopterin concentration in cerebrospinal fluid (CSF), as a marker of Central Nervous System (CNS) immune activation. Subsequently, a subgroup of participants underwent a 6-month course of multi-strain probiotics supplementation; this intervention group was evaluated, after probiotic treatment, with a second lumbar puncture and with repeated neurocognitive tests.RESULTS: At T0, all participants showed impaired results in at least one neurocognitive test and elevated neopterin concentrations in CSF. After supplementation with probiotics (T6), the interventional group presented a significant decrease in neopterin concentration and a significant improvement in several neurocognitive tests. In contrast, no significant modifications were observed in the neurocognitive performance of controls between T0 and T6. The CNS Penetration Effectiveness Score of antiretroviral therapy did not show an influence from any of the investigated variables.CONCLUSIONS: Multi-strain probiotic supplementation seems to exert a positive effect on neuroinflammation and neurocognitive impairment in HIV-1 infected subjects, but large trials are needed to support the concept that modulation of the gut microbiota can provide specific neurological benefits in these patients.

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Chinese olive fruit may ameliorate metabolic dysfunction in diabetic rats under high fat diet challenge. "IndyWatch Feed Health"

n/a PMID:  Nutrients. 2017 Oct 15 ;9(10). Epub 2017 Oct 15. PMID: 29036927 Abstract Title:  Chinese Olive (Canarium album L.) Fruit Extract Attenuates Metabolic Dysfunction in Diabetic Rats. Abstract:  Hyperglycemia and dysregulation of lipid metabolism play a crucial role in metabolic dysfunction. The aims of present study were to evaluate the ameliorative effect of the ethyl acetate fraction of Chinese olive fruit extract (CO-EtOAc) on high-fat diet (HFD) and streptozotocin (STZ)-induced diabetic rats. CO-EtOAc, rich in gallic acid and ellagic acid, could markedly decreased the body weight and epididymal adipose mass. In addition, CO-EtOAc increased serum HDL-C levels, hepatic GSH levels, and antioxidant enzyme activities; lowered blood glucose, serum levels of total cholesterol (TC), triglycerides (TG), bile acid, and tumor necrosis factor alpha (TNF); and reduced TC and TG in liver. We further demonstrated that CO-EtOAc mildly suppressed hepatic levels of phosphorylated IRS-1, TNF-, and IL-6, but enhanced Akt phosphorylation. The possible mechanisms of cholesterol metabolism were assessed by determining the expression of genes involved incholesterol transportation, biosynthesis, and degradation. It was found that CO-EtOAc not only inhibited mRNA levels of SREBP-2, HMG-CoAR, SR-B1, and CYP7A1 but also increased the expression of genes, such as ABCA1 and LDLR that governed cholesterol efflux and cholesterol uptake. Moreover, the protein expressions of ABCA1 and LDLR were also significantly increased in the liver of rats supplemented with CO-EtOAc. We suggest that Chinese olive fruit may ameliorate metabolic dysfunction in diabetic rats under HFD challenge.


Zeel may reduce the main two classes of molecules responsible for arthritic pain and inflammation. "IndyWatch Feed Health"

PMID:  Explore (NY). 2007 Jan-Feb;3(1):16-22. PMID: 17234564 Abstract Title:  The homeopathic antiarthitic preparation Zeel comp. N: a review of molecular and clinical data. Abstract:  Zeel comp. N (Zeel) is a homeopathic medication that has been widely used for many years for the treatment of arthritic disorders in a large number of countries worldwide. In recent years, a growing body of clinical and molecular evidence has been accumulating that shed light on the possible antiarthritic effects of this preparation. A number of studies report anti-inflammatory effects from Zeel. In vitro studies have indicated Zeel-mediated inhibition of the pathways involving the enzymes cyclooxygenase-1 and -2, and also the 5-lipoxygenase pathways, affecting levels of both eicosanoids and leukotrienes. Thus, Zeel may reduce the main two classes of molecules responsible for arthritic pain and inflammation. This review describes recent research on Zeel and discusses the need for further studies to clarify the role of the compound in the antiarthritic armamentarium of complementary medicine.

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Dietary administration of black raspberry inhibits oral carcinogenesis via inhibition of pro-inflammatory and anti-apoptotic pathways. "IndyWatch Feed Health"

PMID:  Front Immunol. 2017 ;8:1325. Epub 2017 Oct 23. PMID: 29109723 Abstract Title:  Inhibition of Pro-inflammatory and Anti-apoptotic Biomarkers during Experimental Oral Cancer Chemoprevention by Dietary Black Raspberries. Abstract:  Oral cancer continues to be a significant public health problem worldwide. Recently conducted clinical trials demonstrate the ability of black raspberries (BRBs) to modulate biomarkers of molecular efficacy that supports a chemopreventive strategy against oral cancer. However, it is essential that a preclinical animal model of black raspberry (BRB) chemoprevention which recapitulates human oral carcinogenesis be developed, so that we can validate biomarkers and evaluate potential mechanisms of action. We therefore established the ability of BRBs to inhibit oral lesion formation in a carcinogen-induced rat oral cancer model and examined potential mechanisms. F344 rats were administered 4-nitroquinoline 1-oxide (4NQO) (20g/ml) in drinking water for 14weeks followed by regular drinking water for 6weeks. At week 14, rats were fed a diet containing either 5 or 10% BRB, or 0.4% ellagic acid (EA), a BRB phytochemical. Dietary administration of 5 and 10% BRB reduced oral lesion incidence and multiplicity by 39.3 and 28.6%, respectively. Histopathological analyses demonstrate the ability of BRBs and, to a lesser extent EA, to inhibit the progression of oral cancer. Oral lesion inhibition by BRBs was associated with a reduction in the mRNA expression of pro-inflammatory biomarkers Cxcl1, Mif, and Nfe2l2 aswell as the anti-apoptotic and cell cycle associated markers Birc5, Aurka, Ccna1, and Ccna2. Cellular proliferation (Ki-67 staining) in tongue lesions was inhibited by BRBs and EA. Our study demonstrates that, in the rat 4NQO oral cancer model, dietary administration of BRBs inhibits oral carcinogenesis via inhibition of pro-inflammatory and anti-apoptotic pathways.

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Homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. "IndyWatch Feed Health"

PMID:  Homeopathy. 2016 Aug ;105(3):257-264. Epub 2016 May 4. PMID: 27473547 Abstract Title:  Homeopathic treatments modify inflammation but not behavioral response to influenza antigen challenge in BALB/c mice. Abstract:  BACKGROUND: Influenza affects thousands of people worldwide every year, motivating the development of new therapies. In this work, the effects of two homeopathic preparations (influenza biotherapies and thymulin) were chosen following two different rationales: isotherapy and endo-isotherapy models. The homeopathic effects were evaluated individually considering the inflammatory and behavioral responses against influenza virus antigen were studied in BALB/c mice.METHODS: Male adult mice were treated orally and blindly for 21 days with highly diluted influenza virus or with thymulin, and were divided in two sets of experiments. The first series of experiments aimed to describe their behavior, using an open field (OF) device. In the second series, mice were challenged subcutaneously with influenza hemagglutinin antigen (7 g/200 l) at day 21. At day 42, behavior and inflammation response were evaluated.RESULTS: No behavioral changes were seen in OF tests at any time point after treatments. Flow cytometry and morphometry revealed significant changes in T and B cell balance after influenza antigen challenge, varying according to treatment.CONCLUSION: The results show that both homeopathic treatments induced subtle changes in acquired immune anti-viral response regulation. A deeper understanding of the mechanism could elucidate their possible use in influenza epidemiological situations.

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Patients exposed to dental amalgam fillings were 1.583 times more likely to have Parkinsons disease. "IndyWatch Feed Health"

PMID:  PLoS One. 2016 ;11(12):e0166552. Epub 2016 Dec 1. PMID: 27906991 Abstract Title:  Association between History of Dental Amalgam Fillings and Risk of Parkinson's Disease: A Population-Based Retrospective Cohort Study in Taiwan. Abstract:  The impact of dental amalgam on the development of Parkinson's disease (PD) is still uncertain, although a positive association between dental amalgam and PD has been found in a few case-control studies. The patients with amalgam fillings restored between 2000 and 2008 were identified by using the National Health Insurance Research Database (NHIRD) in Taiwan. The same number of patients who had no new amalgam filling restored was matched by sex, age, and treatment date. Both cohorts were followed up from the treatment date until the date of diagnosis of PD, death, or the end of the year 2008. The individuals who received amalgam fillings had a significantly higher risk of PD afterward (adjusted hazard ratio [HR]=1.583, 95% confidence interval [CI]=1.122-2.234, p=0.0089) than those who did not. In the individuals who received amalgam fillings, being diagnosed with diabetes or hyperlipidemia demonstrated a significantly lower HR of PD occurrence than in the patients without diabetes or hyperlipidemia (HR=0.449, 95% CI=0.254-0.794, p=0.0059; HR=0.445, 95% CI=0.260-0.763, p=0.0032) after adjusting for comorbidities and Charlson-Deyo Comorbidity Index (CCI) scores. Meanwhile, hypertension increased the hazard risk of PD (HR=1.645, 95% CI=1.098-2.464, p=0.0159). The patients exposed to dental amalgam fillings were 1.583 times more likely to have PD afterward compared to their non-exposed counterparts after adjusting for comorbidities and CCI scores.

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In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. "IndyWatch Feed Health"

PMID:  Can J Physiol Pharmacol. 2007 Nov ;85(11):1084-90. PMID: 18066110 Abstract Title:  In vitro evaluation of the antiviral effects of the homeopathic preparation Gripp-Heel on selected respiratory viruses. Abstract:  Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in vitro cytotoxicity of Gripp-Heel was determined with cells used for the infection experiments (HeLa, HEp-2, MDCK, BGM) as well as with mitogen-stimulated peripheral blood mononuclear leukocytes. A concentration of 0.5 of the commercially available product slightly reduced cell viability and proliferative capacity, and experiments on antiviral activity were determined starting with a dilution of 0.2 of the commercially available product. The antiviral activity was determined against a broad panel of enveloped and nonenveloped DNA and RNA viruses with plaque reduction assay, cytopathogenic assays, virus titrations, analysis of the viral proteins in virus-specific enzyme immunoassays, and haemagglutination tests. Control substances were acyclovir (10 microg/mL), ribavirin (6 microg/mL), and amantadine hydrochloride (5 microg/mL), depending on the virus type. Gripp-Heel demonstrated dose-dependent in vitro activity (significant reductions of infectivity by 20% to 40%) against Human herpesvirus 1, Human adenovirus C serotype 5, Influenza A virus, Human respiratory syncytial virus, Human parainfluenza virus 3, Human rhinovirus B serotype 14, and Human coxsackievirus serotype A9. The mechanisms of this antiviral activity are still unclear, but type I interferon induction might be a possible explanation. Further research on this homeopathic preparation seems warranted.

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The homeopathic combination preparation Zeel was beneficial in alleviating chronic orthopedic pain in dogs. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2009 Dec ;6(4):465-71. Epub 2007 Oct 25. PMID: 18955260 Abstract Title:  Evaluating complementary therapies for canine osteoarthritis--Part II: a homeopathic combination preparation (Zeel). Abstract:  A homeopathic combination preparation (HCP) for canine osteoarthritic pain was evaluated in a randomized, double-controlled and double-blinded clinical trial. Forty-four dogs with osteoarthritis (OA) that were randomly allocated into one of three groups completed the study. All dogs were fed test products or placebo for 8 weeks. The dogs were evaluated at the clinic four times, with 4-week intervals. Six different variables were assessed: veterinary-assessed mobility, two force plate variables, an owner-evaluated chronic pain index and pain and locomotion visual analogue scales (VASs). Intake of extra non-steroidal anti-inflammatory drugs was also evaluated. A Chi-squared test and a Mann-Whitney test were used to determine significant improvement between groups. When changed into dichotomous responses of 'improved' or 'not improved' three out of the six variables showed a significant difference (P = 0.016, P = 0.008, P = 0.039) in improved dogs per group, between the HCP group and the placebo group. The odds ratios were over one for the same variables. As extent of improvement in the variables from start to end of treatment, the HCP product was significantly more improved in four (P = 0.015, P = 0.028, P = 0.049, P = 0.020) of the six variables, compared with the placebo. Our results indicated that the HCP Zeel(R) was beneficial in alleviating chronic orthopedic pain in dogs although it was not as effective as carprofen.

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The homeopathic preparation Nervoheel N can offer an alternative to lorazepam therapy for mild nervous disorders. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2009 Dec ;6(4):507-15. Epub 2007 Oct 25. PMID: 18955261 Abstract Title:  The homeopathic preparation Nervoheel N can offer an alternative to lorazepam therapy for mild nervous disorders. Abstract:  In an open-label, prospective non-randomized cohort study, we compared the effectiveness and tolerability profiles of the homeopathic remedy Nervoheel N with those of the benzodiazepine, lorazepam, in 248 patients with insomnia, distress, anxieties, restlessness or burnout and similar nervous conditions ('mild nervous disorders'). Patients were treated with Nervoheel N or lorazepam at the recommended doses for a maximum of 4 weeks. Dose variations were allowed if in the patient's best interest. Treatment effects were evaluated by the practitioner in a dialogue with the patient at the start of treatment, after 2 weeks and after maximally 4 weeks of treatment. Tolerability data were recorded as adverse events. At baseline, lorazepam patients were on average slightly older and there was a somewhat greater percentage of men in this group than in the Nervoheel group. Both treatment groups reported significant symptomatic improvements of similar magnitude during the course of the study. The sum of symptom scores improved by 4.4 points with Nervoheel N and by 4.2 points with lorazepam. The differences between the treatment groups were not significant. All differences between treatments were within 10% of the maximum score ranges, demonstrating non-inferiority of Nervoheel N. Both treatments were well tolerated, with few adverse events and very good self-assessed tolerability ratings by the patients. Thus, in patients who opt for a homeopathic treatment regimen for the short-term relief of mild nervous disorders, the effects of Nervoheel N are non-inferior to those of lorazepam.

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Black raspberry extract and protocatechuic acid can inhibit initiation of carcinogenesis by polycyclic aromatic hydrocarbons. "IndyWatch Feed Health"

PMID:  Cancer Prev Res (Phila). 2016 Aug ;9(8):704-12. Epub 2016 Jun 7. PMID: 27267891 Abstract Title:  Effects of Black Raspberry Extract and Protocatechuic Acid on Carcinogen-DNA Adducts and Mutagenesis, and Oxidative Stress in Rat and Human Oral Cells. Abstract:  Effects of black raspberry (BRB) extract and protocatechuic acid (PCA) on DNA adduct formation and mutagenesis induced by metabolites of dibenzo[a,l]pyrene (DBP) were investigated in rat oral fibroblasts. The DBP metabolites, ()-anti-11,12-dihydroxy-11,12,-dihydrodibenzo[a,l]pyrene (DBP-diol) and 11,12-dihydroxy-13,14-epoxy-11,12,13,14-tetrahydrodibenzo[a,l]pyrene (DBPDE) induced dose-dependent DNA adducts and mutations. DBPDE was considerably more potent, whereas the parent compound had no significant effect. Treatmentwith BRB extract (BRBE) and PCA resulted in reduced DBP-derived DNA adduct levels and reduced mutagenesis induced by DBP-diol, but only BRBE was similarly effective against (DBPDE). BRBE did not directly inactivate DBPDE, but rather induced a cellular response-enhanced DNA repair. When BRBE was added to cells 1 day after the DBP-diol, the BRBE greatly enhanced removal of DBP-derived DNA adducts. As oxidative stress can contribute to several stages of carcinogenesis, BRBE and PCA were investigated for their abilities to reduce oxidative stress in a human leukoplakia cell line by monitoring theredox indicator, 2',7'-dichlorodihydrofluorescein diacetate (H2DCF) in cellular and acellular systems. BRBE effectively inhibited the oxidation, but PCA was only minimally effective against H2DCF. These results taken together provide evidence that BRBE and PCA can inhibit initiation of carcinogenesis by polycyclic aromatic hydrocarbons; and in addition, BRBE reduces oxidative stress. Cancer Prev Res; 9(8); 704-12. 2016 AACR.

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Black raspberry extract reduces bulky DNA damage and mutagenesis and support a role for BRB in the inhibition of initiation of carcinogenesis. "IndyWatch Feed Health"

PMID:  Chem Res Toxicol. 2017 Nov 15. Epub 2017 Nov 15. PMID: 29068672 Abstract Title:  Effects of Black Raspberry Extract and Berry Compounds on Repair of DNA Damage and Mutagenesis Induced by Chemical and Physical Agents in Human Oral Leukoplakia and Rat Oral Fibroblasts. Abstract:  Black raspberries (BRB) have been shown to inhibit carcinogenesis in a number of systems, with most studies focusing on progression. Previously we reported that an anthocyanin-enriched black raspberry extract (BE) enhanced repair of dibenzo-[a,l]-pyrene dihydrodiol (DBP-diol)-induced DNA adducts and inhibited DBP-diol and DBP-diolepoxide (DBPDE)-induced mutagenesis in a lacI rat oral fibroblast cell line, suggesting a role for BRB in the inhibition of initiation of carcinogenesis. Here we extend this work to protection by BE against DNA adduct formation induced by dibenzo-[a,l]-pyrene (DBP) in a human oral leukoplakia cell line (MSK) and to a second carcinogen, UV light. Treatment of MSK cells with DBP and DBPDE led to a dose-dependent increase in DBP-DNA adducts. Treatment of MSK cells with BE after addition of DBP reduced levels of adducts relative to cells treated with DBP alone, and treatment of rat oral fibroblasts with BE after addition of DBPDE inhibited mutagenesis. These observations showed that BE affected repair of DNA adducts and not metabolism of DBP. As a proof of principle we also tested aglycones of two anthocyanins commonly found in berries, delphinidin chloride and pelargonidin chloride. Delphinidin chloride reduced DBP-DNA adduct levels in MSK cells, while PGA did not. These results suggested that certain anthocyanins can enhance repair of bulky DNA adducts. As DBP and its metabolites induced formation of bulky DNA adducts, we investigated the effects of BE on genotoxic effects of a second carcinogen that induces bulky DNA damage, UV light. UV irradiation produced a dose-dependent increase in cyclobutanepyrimidine dimer levels in MSK cells, and post-UV treatment with BE resulted in lower cyclobutanepyrimidine dimer levels. Post-UV treatment of the rat lacI cells with BE reduced UV-induced mutagenesis. Taken together, the results demonstrate that BE extract reduces bulky DNA damage and mutagenesis and support a role for BRB in the inhibition of initiation of carcinogenesis.

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Homeopathic ear drops may be effective in reducing the use of antibiotics in children with acute otitis media. "IndyWatch Feed Health"

PMID:  Glob Pediatr Health. 2014 ;1:2333794X14559395. Epub 2014 Nov 21. PMID: 27335917 Abstract Title:  Homeopathic Ear Drops as an Adjunct in Reducing Antibiotic Usage in Children With Acute Otitis Media. Abstract:  Objective. To determine if use of a homeopathic ear drop preparation reduces antibiotic use in children diagnosed with acute otitis media (AOM). Methods. Children 6 months to 11 years old, diagnosed with AOM and managed with a delayed antibiotic approach, were randomized to standard therapy alone or standard therapy plus a homeopathic ear drop preparation. The primary outcome was whether or not the antibiotic prescription given at the index visit was filled during a 12- to 15-day follow-up period. Results. Among 210 enrolled children, follow-up antibiotic data were collected on 206. During the 12- to 15-day follow-up period, fewer parents of children randomized to the homeopathic ear drops group filled the antibiotic prescription compared with those of children receiving standard therapy alone (26.9% and 41.2%, respectively, P = .032). Conclusion. Homeopathic ear drops may be effective in reducing the use of antibiotics in children with AOM managed with a delayed antibiotic approach.

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Wednesday, 22 November


Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines. "IndyWatch Feed Health"

PMID:  Homeopathy. 2014 Oct ;103(4):264-74. Epub 2014 Oct 3. PMID: 25439043 Abstract Title:  Modulation of inflammation response to murine cutaneous Leishmaniasis by homeopathic medicines: Antimonium crudum 30cH. Abstract:  BACKGROUND: Leishmaniasis is a zoonotic disease caused by protozoan parasites of the mononuclear phagocytic system. The modulation activity of these cells can interfere in the host/parasite relationship and influences the prognosis.METHODS: We evaluated the effects of the homeopathic preparation Antimonium crudum 30cH on experimental infection induced by Leishmania (L.) amazonensis. Male Balb/c mice were inoculated with 2 10(6)Leishmania (L.) amazonensis promastigotes into the footpad and, after 48 h (acute phase) or 60 days (chronic phase), cell population of lymphocytes and phagocytes present in the peritoneal washing fluid and spleen were analyzed by flow cytometry and histopathology, with histometry of the subcutaneous primary lesion, local lymph node and spleen. Immunohistochemistry was performed to quantify CD3 (T lymphocyte), CD45RA (B lymphocyte) and CD11b (phagocytes) positive cells.RESULTS: In treated mice, during the acute phase, there was significant increase of the macroscopic lesion, associated to inflammatory edema, as well increase in the number of free amastigotes and B lymphocytes inside the lesion. Increase of B lymphocytes (predominantly B-2 cells) was also seen in the local lymph node, spleen and peritoneum. In the chronic phase, the inflammatory process in the infection focus was reduced, with reduced phagocyte migration and peritoneal increase of B-1a cells (precursors of B-2 immunoglobulin producers cells) and T CD8+ cells.CONCLUSION: The treatment of mice with Antimonium crudum 30cH induced a predominantly B cell pattern of immune response in Leishmania (L.) amazonensis experimental infection, alongside the increase of free amastigote forms number in the infection site. The clinical significance of this study is discussed, further studies are suggested.

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The Path You Pick Reveals Your Personality and Future "IndyWatch Feed Health"

Congratulations! You are on the road trip of your dreams to a destination only you know. But if you had to make a pitstop along the way, where would you go?  Heres how the quiz works: Choose a mid-trip destination from one of the picturesque options above and then scroll down to see what your mid-trip destination... View Article

The post The Path You Pick Reveals Your Personality and Future appeared first on Healthy Holistic Living.


The homeopathic treatment shortened upper respiratory tract infection duration, and reduced the use of symptomatic medication. "IndyWatch Feed Health"

PMID:  Forsch Komplementmed. 2015 ;22(3):163-70. Epub 2015 May 12. PMID: 26335189 Abstract Title:  A Homeopathic Combination Preparation in the Treatment of Feverish Upper Respiratory Tract Infections: An International Randomized Controlled Trial. Abstract:  BACKGROUND: Upper respiratory tract infections (URTI) are very common and associated with considerable healthcare costs. We evaluated the clinical benefit of a homeopathic add-on therapy.PATIENTS AND METHODS: In this randomized controlled multinational clinical trial, patients (age range 1-65 years) with feverish URTI received either on-demand symptomatic standard treatment (ST group: paracetamol, ambroxol, and/or oxymetazoline), or homeopathic medication (IFC group: Influcid) for 7 days plus the same on-demand standard treatment. URTI symptoms were assessed using the Wisconsin Upper Respiratory Symptom Survey-21. Response at day 4, defined as absence of fever and absence or very mild degree of URTI symptoms, was the primary outcome measure.RESULTS: 523 patients (265 IFC group, 258 ST group) were randomized in 12 Ukrainian and 10 German centers. The responder rate on day 4 was 15.4% in the IFC group and 6.7% in the ST group (x0394;IFC-ST = 8.7%, 95% confidence interval 2.9-14.5%). The IFC group used less symptomatic medication, and symptoms were alleviated 1-2 days earlier. 3 and 8 adverse events (AEs) in the IFC and ST group, respectively, were assessed as possibly treatment-related; 2 out of the 3 AEs in the IFC group were possibly related to symptomatic therapy, 1 (vomiting) to IFC treatment.CONCLUSION: The homeopathic treatment shortened URTI duration, reduced the use of symptomatic medication, and was well tolerated.

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Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin glycation. "IndyWatch Feed Health"

PMID:  Homeopathy. 2015 Jul ;104(3):197-204. Epub 2015 Jun 15. PMID: 26143453 Abstract Title:  Syzygium jambolanum and Cephalandra indica homeopathic preparations inhibit albumin glycation and protect erythrocytes: an in vitro study. Abstract:  BACKGROUND: Diabetes mellitus is a common endocrine disorder characterized by hyperglycemia eventually resulting in long-term complications. Increased glycation of proteins is implicated in the pathogenesis of complications. For treatment of diabetes, Syzygium jambolanum and Cephalandra indica are frequently prescribed in homeopathy. However their role in glycation is not well elucidated. The present study aimed to evaluate the role of these homeopathic preparations in glycation induced structural modifications and further to examine their cellular protection ability.METHODS: In human erythrocytes, in vitro mother tincture and dilutions of S. jambolanum (Sj , 30c, 200c), C. indica (Ci , 30c, 200c) and standard antiglycator (AG) were compared and their antiglycation potential assessed by the estimating different markers of glycation (frcutosamines, carbonyls, bound sugar), structural modifications (free amino and thiol group). Phytochemical characterization (total phenolic, flavonoids and glycosides contents) was performed.RESULTS: The homeopathic preparations have different mode of action on albumin glycation modifications. Sj preparation demonstrated effective inhibition of all glycation, structural modifications except amino group protection. When dilutions were compared, Sj preparations showed reduction of glycation, structural modifications. All preparations showed significant erythrocyte protection. Sj preparation exhibited noteworthy antiglycation and cell protection ability as compared to AG.CONCLUSION: These homeopathic preparations especially Sj prevented glycation induced albumin modifications and subsequent toxicity in human eryrthrocytre in vitro. Further investigation of their potential as antiglycators is justified.

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Potentized estrogen at a dose of 3 drops twice daily for 24 weeks was effective in reducing endometriosis-associated pelvic pain. "IndyWatch Feed Health"

PMID:  Eur J Obstet Gynecol Reprod Biol. 2017 Apr ;211:48-55. Epub 2017 Jan 25. PMID: 28187404 Abstract Title:  Potentized estrogen in homeopathic treatment of endometriosis-associated pelvic pain: A 24-week, randomized, double-blind, placebo-controlled study. Abstract:  OBJECTIVE: To evaluate the efficacy and safety of potentized estrogen compared to placebo in homeopathic treatment of endometriosis-associated pelvic pain (EAPP).STUDY DESIGN: The present was a 24-week, randomized, double-blind, placebo-controlled trial that included 50 women aged 18-45 years old with diagnosis of deeply infiltrating endometriosis based on magnetic resonance imaging or transvaginal ultrasound after bowel preparation, and score5 on a visual analogue scale (VAS: range 0 to 10) for endometriosis-associated pelvic pain. Potentized estrogen (12cH, 18cH and 24cH) or placebo was administered twice daily per oral route. The primary outcome measure was change in the severity of EAPP global and partial scores (VAS) from baseline to week 24, determined as the difference in the mean score of five modalities of chronic pelvic pain (dysmenorrhea, deep dyspareunia, non-cyclic pelvic pain, cyclic bowel pain and/or cyclic urinary pain). The secondary outcome measures were mean score difference for quality of life assessed with SF-36 Health Survey Questionnaire, depression symptoms on Beck Depression Inventory (BDI), and anxiety symptoms on Beck Anxiety Inventory (BAI).RESULTS: The EAPP global score (VAS: range 0 to 50) decreased by 12.82 (P

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Bumps on Face: Causes and Effective Treatments (Science Based) "IndyWatch Feed Health"

Bumps on the face can come in many shapes and sizes. Skin conditions like acne can cause red bumps that may have a pus-filled white center. Or, you may notice that little white bumps around your eyes or cheeks have appeared. Other types of facial bumps could look like a bumpy rash that isnt acne with hard, flesh-colored bumps that wont pop, or you may notice a dark mole appearing that needs to be examined by a dermatologist.

Noticing any kind of bump on your face can be a cause for concern, at least from a cosmetic point of view. A large red bump on your face will make you very self-conscious. Even just having clusters of tiny blackheads or whiteheads is enough to reach for concealer to cover up the unsightly spots.

The causes of bumps appearing on your face are many and varied. Having an oily complexion or too much sebum on your face can block pores that become infected and inflamed. Or, having an oily face could result in groups of blackheads on your nose, cheeks, or forehead. A viral infection could also cause sore bumps on your lips that ooze fluid before crusting over.

How can you get a clear complexion and get rid of bumps on your face? Should you try to pop bumps on your face to remove them?

In this article, you will learn about facial bumps and what to do to get rid of them from your face.

How do Bumps on Face Look Like?

You might have large red facial bumps if they are caused by infected or blocked pores on your forehead, cheeks, chin or nose, These can appear as just one or two pimples or you may have a cluster of inflamed and swollen red pores. These pustules may be tender to touch and become filled with pus.

Not all bumps that appear on your face are caused by acne and become red pimples that look unsightly. Raised skin bumps can sometimes be a result of a keratin buildup under your skin that causes small white bumps or skin colored bumps on your face. These types of spots generally dont have other symptoms other than giving your face a bumpy appearance.

Causes of Bumps on Face

What can be causing the outbreak of bumps on your face and how can you prevent these facial bumps becoming worse?

Razor burn and razor bumps on face

Shaving facial hair is one reason why many men get red sore bumps on their face.

Razors bumps (medical name: pseudofolliculitis barbae) are small red bumps that appear on shaved areas of the face. According to dermatologist Dr. Amanda Oakley, razor bumps occur when...


Patients with hemorrhoids had improved symptom severity and anoscopic scores with homeopathy. "IndyWatch Feed Health"

PMID:  J Intercult Ethnopharmacol. 2016 Sep-Dec;5(4):335-342. Epub 2016 Jun 25. PMID: 27757262 Abstract Title:  Treatment of hemorrhoids with individualized homeopathy: An open observational pilot study. Abstract:  AIM: Controversies and disagreement exist on conventional treatment strategies of hemorrhoids due to relapse, inefficacy, and complications. We intend to evaluate the role of individualized homeopathic treatment in hemorrhoids.MATERIALS AND METHODS: In this prospective, open, observational trial, hemorrhoids patients were treated using five standardized scales measuring complaints severity and anoscopic score. It was conducted at two homeopathic hospitals in India, during from mid-July 2014 to mid-July 2015. Patients were intervened as per individualized homeopathic principles and followed up every month up to 6 months.RESULTS: Total 73 were screened, 52 enrolled, 38 completed, 14 dropped out. Intention to treat population (n: = 52) was analyzed in the end. Statistically significant reductions of mean bleeding (month 3: -21.8, 95% confidence interval [CI]: -30.3, -13.3, P:

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Retired Medical Doctor Exposes Deceptive Statistics Used to Justify Billion Dollar Flu Vaccine and Drug Market "IndyWatch Feed Health"

Scientist researching in laboratory.

Flu Shots, Fosamax and Pharmaceutical Fakery: The Common Use of Deceptive Statistics in the Vaccine and Pharmaceutical Literature

by Gary G. Kohls, MD
Duty to Warn

A few years ago, there was a temporary media buzz generated by an article in The Lancet Infectious Disease journal. That highly respected medical journal is, as is true of most such journals, a pro-vaccine, pro-pharmaceutical medical industry publication that is published in London.

The article showed that flu vaccinations were far less effective than had been previously believed. In fact, that particular study suggested that the trivalent flu vaccine currently being pushed at that time approached worthlessness.

The articles principle author was Michael Osterholm, PhD, MPH, a widely published infectious disease researcher who, prior to his current faculty position at the University of Minnesota, had served in various capacities with the CDC and the Minnesota Department of Health (MDH), including a high-profile role as the MDHs Chief of the Acute Disease Epidemiology Section. For 15 years of that association with the MDH he served as Minnesota state epidemiologist. Dr Osterholm, who is not a physician, has published over 300 articles and is highly respected in his field.

The Disconnect Between Real, Unbiased Science and Profit-focused Corporate Propaganda

The Lancet study, in the reports that I listened to on NPR and then did additional research on, was deceptively reported by NPR as being 60% effective thus implying that that seasons trivalent flu vaccine should still be regarded as moderately effective for flu prevention (rather than being brought into question as the nearly worthless vaccine that it was). What could explain the disconnect between the real hard science and the media propaganda?

Seeing no sign of a public retraction from Osterholm or his co-authors about the glaring disconnect, I began to wonder if the researchers were even aware of the depths that so many other medical, psychiatric and pharmaceutical industry researchers have stooped to when their research is reported...


The homeopathic syrup appeared to be effective in reducing the severity of cold symptoms in the first day after beginning treatment. "IndyWatch Feed Health"

PMID:  Complement Ther Med. 2016 Dec ;29:229-234. Epub 2016 Nov 2. PMID: 27912951 Abstract Title:  A randomized controlled trial of a homeopathic syrup in the treatment of cold symptoms in young children. Abstract:  BACKGROUND: There is little evidence that the decongestant, antihistamine, or cough suppressant medications commonly used to treat cold symptoms in preschool children are effective. One option for treating cold symptoms in young children is with homeopathy. This study was conducted to determine if a homeopathic syrup was effective in treating cold symptoms in preschool children.METHODS: Children 2-5 years old diagnosed with an upper respiratory tract infection were randomized to receive a commercial homeopathic cold syrup or placebo. Parents administered the study medication as needed for 3days. The primary outcome was change in symptoms one hour after each dose. Parents also assessed the severity of each of the symptoms of runny nose, cough, congestion and sneezing at baseline and twice daily for 3days, using a 4-point rating scale. A composite cold score was calculated by combining the values for each of the four symptoms.RESULTS: Among 261 eligible participants, data on 957 doses of study medication in 154 children were analyzed. There was no significant difference in improvement one hour after the dose for any symptom between the two groups. Analysis of twice daily data on the severity of cold symptoms compared to baseline values found that improvements in sneezing, cough and the composite cold score were significantly greater at both the first and second assessments among those receiving the cold syrup compared to placebo recipients.CONCLUSION: The homeopathic syrup appeared to be effective in reducing the severity of cold symptoms in the first day after beginning treatment.

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How efforts to reverse climate change could Destroy the planet in catastrophic backfire, scientists warn "IndyWatch Feed Health"

Human efforts to reverse climate change could DESTROY the planet in catastrophic backfire, scientists warn


(Natural News) Reversing climate change seems to be the celebrity cause du jour, and there are many people who feel that significant action is needed to help counteract global warming. Most people want to protect the planet on which we live, but there is a lot of misinformation out there and plenty of debate on the best way to achieve this....


Retired Medical Doctor Exposes Deceptive Statistics Used to Justify Billion Dollar Flu Vaccine and Drug Market "IndyWatch Feed Health"

Scientist researching in laboratory.

Flu Shots, Fosamax and Pharmaceutical Fakery: The Common Use of Deceptive Statistics in the Vaccine and Pharmaceutical Literature

by Gary G. Kohls, MD
Duty to Warn

A few years ago, there was a temporary media buzz generated by an article in The Lancet Infectious Disease journal. That highly respected medical journal is, as is true of most such journals, a pro-vaccine, pro-pharmaceutical medical industry publication that is published in London.

The article showed that flu vaccinations were far less effective than had been previously believed. In fact, that particular study suggested that the trivalent flu vaccine currently being pushed at that time approached worthlessness.

The articles principle author was Michael Osterholm, PhD, MPH, a widely published infectious disease researcher who, prior to his current faculty position at the University of Minnesota, had served in various capacities with the CDC and the Minnesota Department of Health (MDH), including a high-profile role as the MDHs Chief of the Acute Disease Epidemiology Section. For 15 years of that association with the MDH he served as Minnesota state epidemiologist. Dr Osterholm, who is not a physician, has published over 300 articles and is highly respected in his field.

The Disconnect Between Real, Unbiased Science and Profit-focused Corporate Propaganda

The Lancet study, in the reports that I listened to on NPR and then did additional research on, was deceptively reported by NPR as being 60% effective thus implying that that seasons trivalent flu vaccine should still be regarded as moderately effective for flu prevention (rather than being brought into question as the nearly worthless vaccine that it was). What could explain the disconnect between the real hard science and the media propaganda?

Seeing no sign of a public retraction from Osterholm or his co-authors about the glaring disconnect, I began to wonder if the researche...


Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum. "IndyWatch Feed Health"

PMID:  Cytokine. 2017 Jul ;95:97-101. Epub 2017 Feb 27. PMID: 28254560 Abstract Title:  Homeopathic medicines cause Th1 predominance and induce spleen and megakaryocytes changes in BALB/c mice infected with Leishmania infantum. Abstract:  The prevalence of Th1/Th2 response, spleen changes and megakaryocytes were investigated in BALB/c mice (n=138) infected with Leishmania infantum, and treated with Leishmania infantum 30 (10(-30)) biotherapy - BioLi30. We performed controlled experiments using 8-to-12-week-old mice, infected with 510(7)L. infantum promastigotes, divided into eight groups: G1 (healthy), G2 (infected with L. infantum), G3 (BioLi30 pre-treated), G4 (BioLi30 pre/post-treated), G5 (BioLi30 post-treated), G6 (Water 30 post-treated), G7 (Antimonium crudum 30 post-treated) and G8 (Glucantime post-treated). G3-G7 groups were orally treated with their respective drugs diluted in filtered water (1:10), and G8 received Glucantime (0.6mg/100l of PBS), intraperitoneally. Spleen fragments were submitted to double blind histopathological evaluation and the number of megakaryocytes was counted. Besides, animals' serum was measured after 49days of infection, and cytokines (IFN-, IL-4, IL-10, IL-12), as well as the Th1/Th2 correlation (IFN-/IL-4 and IFN-/IL-10), were analyzed.Spleen histological parameters were classified as: healthy appearance (G1); discreet (G3-G7), moderate (G2) and moderate to severe (G8) white pulp hyperplasia; proliferation of megakaryocytes (G2-G8), and intense disruption (G2-G8). All groups, except for G7, showed higher percentages of megakaryocytes per field ranging from 87% to 15%, when compared to healthy animals (G1). Th1 predominance in IFN-/IL-4 ratio (comparing to G2) was detected in G4, G5, G6 and G7. Finally, pre/post (BioLi30x) and post-treatment (Antimonium crudum 30x) presented reduction of megakaryocytes/spleen changes due toimmunomodulation animal process, controlling the infection process, probably by the Th1 cytokine predominance.

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Homeopathy outperforms antibiotics treatment in juvenile scallop. "IndyWatch Feed Health"

PMID:  Homeopathy. 2017 Feb ;106(1):18-26. Epub 2017 Jan 10. PMID: 28325219 Abstract Title:  Homeopathy outperforms antibiotics treatment in juvenile scallop Argopecten ventricosus: effects on growth, survival, and immune response. Abstract:  BACKGROUND: Mortality from vibriosis in mollusk production is attributed to pathogenic bacteria, particularly Vibrio alginolyticus. Use of increasingly potent antibiotics has led to bacterial resistance and increased pathogenicity. Alternatives in sanitation, safety, and environmental sustainability are currently under analysis. To-date, homeopathy has been investigated in aquaculture of freshwater fish, but not in marine mollusks. The effect of the homeopathic complexes in the growth, survival, and immune response of the Catarina scallop Argopecten ventricosus were assessed.METHODS: A bioassay to assess the potential of homeopathy in improving cultivation of juvenile A. ventricosus was conducted for 21 days, with a final challenge of 120 h with V. alginolyticus. The experimental design included two homeopathic formulas The homeopathic complex Passival, consisting of Passiflora incarnata 30 CH, Valeriana officinalis 30 CH, Ignatia amara 30 CH and Zincum valerianicum 30 CH plus Phosphoricum acid 30 CH (treatment TH1) or Silicea terra 30 CH (TH2), two antibiotics (ampicillin = AMP, oxytetracycline = OXY), and two reference treatments (without homeopathic or antibiotic treatment = CTRL, ethanol 30 GL = ETH). Additionally, a negative control CTRL- (untreated/uninfected) is included in the challenge test. Juvenile scallops (4.14  0.06 mm, 13.33 mg wet weight) were cultivated in 4 L tanks provided with aerated, filtered (1 m), and UV-sterilized seawater that was changed every third day. They were fed a blend of the microalgae Isochrysis galbana and Chaetoceros calcitrans (150,000 cells mL(-1) twice a day). All treatments were directly added to the tank water and then 500 mL challenge units were inoculated with 1  10(7) CFU/mL (LD50) of V. alginolyticus.RESULTS: Juveniles grew significantly larger and faster in height and weight with TH2 compared to the ETH and CTRL (P

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Prevention of poison ivy dermatitis with oral homeopathic Rhus toxicodendron. "IndyWatch Feed Health"

PMID:  Dermatol Online J. 2017 Jan 15 ;23(1). Epub 2017 Jan 15. PMID: 28329482 Abstract Title:  Prevention of poison ivy dermatitis with oral homeopathic Rhus toxicodendron. Abstract:  Acute allergic contact dermatitis to poison ivy is acommon and miserable dermatosis which affectsmillions of Americans each year. Preventativemeasures, such as avoidance, protective clothing,barrier creams, soaps, and solvents often fail despiteour patients' best attempts. Severe allergic reactionsto poison ivy are a significant source of decreasedemployee productivity owing to inability to work anda major health care expenditure. Patients may haveto leave their jobs and discontinue favorite outdoorrecreational activities as a result of severe urushiolsensitivity. Thus, a simple and effective method ofpreventing poison ivy dermatitis would be of greatbenefit to clinical dermatologists and their patients.Complementary and alternative medical practitionerscommonly prescribe homeopathic poison ivyproducts by mouth for the prevention of poisonivy dermatitis. Yet, conventional dermatologists aremostly unaware of this little known clinical pearl. Theauthor discusses two open studies and anecdotalexperience with administration of homeopathicpoison ivy in the prevention of acute allergic contactdermatitis related to poison ivy exposure. Potentialadvantages could include patient acceptability,ease of administration, affordability, and availability.Randomized clinical trials are needed to furtherevaluate the safety and efficacy of this interesting andpromising clinical tip.

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The 5 Things You Should Never Say to Your Kids, Experts Say "IndyWatch Feed Health"

When were young we spend our time trying to figure out the world. Everything is new and exciting, and sometimes scary. As children, we take cues about how we should react to our environment from adults, and our parents are our biggest teachers, whether we realize it or not.  During childhood, the brains neuroplasticity is... View Article

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A homeopathic and a conventional nasal spray produced equivalent improvements in nasal and ocular symptoms. "IndyWatch Feed Health"

PMID:  J Altern Complement Med. 2017 Jun ;23(6):426-444. Epub 2017 Feb 16. PMID: 28437146 Abstract Title:  Homeopathy for Allergic Rhinitis: A Systematic Review. Abstract:  OBJECTIVE: The aim of this study was to evaluate the efficacy and effectiveness of homeopathic intervention in the treatment of seasonal or perennial allergic rhinitis (AR).METHOD: Randomized controlled trials evaluating all forms of homeopathic treatment for AR were included in a systematic review (SR) of studies published up to and including December 2015. Two authors independently screened potential studies, extracted data, and assessed risk of bias. Primary outcomes included symptom improvement and total quality-of-life score. Treatment effect size was quantified as mean difference (continuous data), or by risk ratio (RR) and odds ratio (dichotomous data), with 95% confidence intervals (CI). Meta-analysis was performed after assessing heterogeneity and risk of bias.RESULTS: Eleven studies were eligible for SR. All trials were placebo-controlled except one. Six trials used the treatment approach known as isopathy, but they were unsuitable for meta-analysis due to problems of heterogeneity and data extraction. The overall standard of methods and reporting was poor: 8/11 trials were assessed as"high risk of bias"; only one trial, on isopathy for seasonal AR, possessed reliable evidence. Three trials of variable quality (all using Galphimia glauca for seasonal AR) were included in the meta-analysis: nasal symptom relief at 2 and 4 weeks (RR=1.48 [95% CI 1.24-1.77] and 1.27 [95% CI 1.10-1.46], respectively) favored homeopathy compared with placebo; ocular symptom relief at 2 and 4 weeks also favored homeopathy (RR=1.55 [95% CI 1.33-1.80] and 1.37 [95% CI 1.21-1.56], respectively). The single trial with reliable evidence hada small positive treatment effect without statistical significance. A homeopathic and a conventional nasal spray produced equivalent improvements in nasal and ocular symptoms.CONCLUSIONS: The low or uncertain overall quality of the evidence warrants caution in drawing firm conclusions about intervention effects. Use of either Galphimia glauca or a homeopathic nasal spray may have small beneficial effects on the nasal and ocular symptoms of AR. The efficacy of isopathic treatment of AR is unclear.

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Oxford County: Annual Reminder Issued for Fluoride and Sodium in Drinking Water Systems "IndyWatch Feed Health"

Natural mineralization in drinking water for some communities could present health considerations for some residents

Oxford County Public Health is issuing an annual reminder to residents about levels of fluoride and sodium in some of the Countys municipal drinking water. Parents with children under six years of age should pay close attention to fluoride exposure to prevent dental fluorosis in children, while those on sodium restricted diets should pay close attention to sodium they may be consuming from municipal water.


While fluoride levels up to 2.4 mg/L are safe to drink, fluoride levels above 1.5 mg/L in municipal drinking water have been reported in the communities of Brownsville, Ingersoll, Lakeside, Springford and Tillsonburg. Fluoride levels above the recommended level of 1.5 mg/L may put children under six years of age at risk for dental fluorosis (discolouration of the teeth). Households with children under six in these communities should use bottled water for baby formula, and cutback on other sources of fluoride, like using non-fluoride toothpaste.
Fluoride is not added to Oxford County drinking water, but is naturally present in some of the water systems.

Read the full Health Information Advisory for fluoride.


Sodium levels in drinking water are only a concern for individuals on a sodium-restricted diet. This includes people with kidney disease, heart disease, high blood pressure or liver disease. These residents should speak with their physician or health care provider about how sodium in the water may affect their health. Communities with sodium levels that range above the recommended level of 20mg/L include: Bright, Brownsville, Embro, Ingersoll, Norwich, Otterville, Springford, Thamesford, Tillsonburg and Woodstock.

Read the full Health Information Advisory for sodium.

Oxford Countys 17 municipal drinking water systems are monitored 24/7 to ensure its safety and quality. In 2015, Oxford County Public Works treated and supplied 11.6 million cubic metres of drinking water.


Fluoride and sodium are naturally occurring minerals in Oxford Countys water supply. While these minerals are harmless for most people, those with health challenges that could be impacted by excess sodium in their diet should be keenly aware of the sodium content in drinking water. As well, parents in certain communities should be aware o...


Individualized homeopathic treatment was associated with better glycaemic control compared with standard conventional treatment alone. "IndyWatch Feed Health"

PMID:  Homeopathy. 2017 May ;106(2):79-86. Epub 2017 Mar 17. PMID: 28552177 Abstract Title:  Individualized homeopathic treatment in addition to conventional treatment in type II diabetic patients in Hong Kong - a retrospective cohort study. Abstract:  OBJECTIVE: Glycaemic goals are not achieved in most patients with type II diabetes mellitus (T2DM), especially in those with long disease duration and taking multiple oral antidiabetic drugs (OAD). We aimed to investigate the effectiveness of individualized homeopathic treatment in glycaemic control.DESIGN: Retrospective cohort study.SETTING: At least 6 months of individualized homeopathic treatment at a private homeopathic centre in Hong Kong.PARTICIPANTS: Twenty-seven adults aged 37-84 years were treated with individualized homeopathic remedies between 2012 and 2015. Published data on 40 T2DM patients under standard conventional treatment in Hong Kong were used as a control.MAIN OUTCOME MEASURE: Change in fasting plasma glucose (FPG) and glycated haemoglobin (HbA1c) at 12-month or the last follow-up, whichever is earlier.RESULTS: Compared with the conventional treatment only group, the homeopathy group had higher baseline FPG (p = 0.044), and more patients had a long (>20 years) duration of diabetes (p = 0.006), and a history of cardiac events (p = 0.022). The mean difference in FPG in the homeopathy group was significantly greater than in the control after 12 months: -2.24 mmol/L (95% confidence interval [CI]: -3.47 to -1.01) vs 0.16 mmol/L (95% CI: -1.72 to 2.04), p = 0.001. The mean difference in glycated haemoglobin (HbA1c) was also significantly greater, -1.11% (95% CI: -2.17 to -0.05) vs 0.08% (95% CI: -1.37 to 1.53), p = 0.046. Poorer baseline glycaemic control was associated with better outcome (r = -0.750, p 

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6 Ways You Can Save the World Everyday "IndyWatch Feed Health"

The news is often depressing, the environment is under attack and it can easily seem overwhelming to try and make the slightest difference in the world. Despite this, you still try. We all do. No matter how bad things get, we persevere in trying to make them bettersometimes we need a reminder, though, that our efforts really do count. If youre feeling burnt out, or getting close, focus on small everyday initiatives that use your energy effectively and provide the satisfaction of knowing youve made a difference. The following six tips are a few ways you can accomplish this.

Saving the world doesnt have to be a monumental undertaking. You save the world a little bit every day when you make the right choices and choose to invest in the world. Rather than get caught up in the pressure to perform, take on little projects that will cumulatively make a great impact on yourself, your community and the world.

Take Care of Yourself

Have you ever stopped to consider your self-care routine? According to The Atlantic, self-care is an imperative part of every persons health and wellbeing. What is it, thoughand how do you practice it? Self-care simply refers to the act of attuning to ones own needs and prioritizing ones own wellness. Too often, we spend busy days ignoring hunger, dealing with negative feelings or medicating pain rather than addressing it directly. All of these behaviors are detrimental, an...


1080: Operation to protect Northern Ruahine species complete "IndyWatch Feed Health"

Note from FAN: Molecular structure of highly toxic Sodium fluoroacetate (known as 1080)

A pest control operation to protect at-risk native species in the Northern Ruahine Ranges has been completed.

The operation was part of the Department of Conservations (DOCs) Battle for our Birds programme, which aims to protect our most vulnerable native species.

Director Operations Lower North Island Reg Kemper, is pleased with how the operation went.

Its early days, but anecdotal reports indicate some wins already, with dead possums, rats and mice reported by our staff and volunteers working in the treatment area, says Reg.

A lot of effort goes in to planning and delivering an operation like this. Its a credit to all those involved; they just got on with it and did the job safely and effectively.

DOC worked with OSPRI (which manages New Zealands TBfree programme) to lay cereal baits containing sodium fluoroacetate (known as 1080) over 32,829ha of the Northern Ruahine Ranges, between 13 and 15 November 2017.

Their work will protect our taonga species across a large area of difficult terrain, explains Reg.

Aerial 1080 is the most effective large-scale pest control tool we currently have. Monitoring shows its successful in protecting our vulnerable species.

The operation will reduce rat, possum and stoat numbers in the area, helping to protect Ruahine populations of highly valued species, such as whio/blue duck, kiwi, giant land snails, bats/pekapeka, red mistletoe, Dactylanthus, and Pittosporum turneri.

Although the operation itself is complete, the work is not over. During the coming months, teams will be gathering data to assess the impact of the operation:
Rat and mouse numbers will be monitored in early December.
Whio populations in two catchments will be surveyed using conservation dogs in late summer.
Powelliphanta snail populations will be monitored in February/March 2018.

Access points into the operational area have warning signs in place. The presence of these signs indicates that pesticide residues may still be present in bait or animals.

For more information, see



Fluoride Question Goes to Edgartown Voters "IndyWatch Feed Health"

The decision about whether to add fluoride to Edgartowns public water supply will now go before voters next April, following a successful petition effort by residents.

The Edgartown town clerks office confirmed Wednesday that a petition had been certified with enough signatures to place the fluoridation question before voters at the annual town meeting next spring. The question will require a vote on the town meeting floor and by ballot at the annual town election, assistant town clerk Karen Medeiros said.

Meanwhile, at a meeting Tuesday, the Edgartown board of health stood by its vote last month to take steps to add fluoride to the water supply. The vote has sparked heated debate at meetings before the board of health and water commission in recent weeks.

Board of health members Harold Zadeh and Dr. Garrett Orazem reaffirmed their Oct. 10 vote to fluoridate the town water supply. The third board member, Kathie Case, abstained from the original vote and was not at the meeting.

The boards decision was published Oct. 20. Under state law, town voters then had 90 days to gather a petition to bring the matter before town meeting.

And while the successful petition ensures a binding vote in the spring, members of the town water commission and other residents at the meeting Tuesday again called on the board of health to rescind its vote. Critics have cited both concerns about the health effects of fluoridation and what they claim was a flawed process.

Board of health members have said the decision was in the interest of public health because fluoride is well established to reduce tooth decay, and that they welcomed a town vote. About 15 people attended the meeting, including two Island dentists who said they back the boards position.

Town health agent Matt Poole said Tuesday that town counsel had advised the board against rescinding the vote.

Mr. Zadeh began the meeting by apologizing for not involving the water commission earlier in the process. Water commissioner David Burke, who led the petition initiative, said discussion about fluoride should have taken place earlier. Were looking for opportunities to be educated. Education should have taken place before the order . . . They should start by educating us, he said.

What else is good for us that could be put in the water, Edgartown resident Maria Thibodeau said, pointing out that vegetables are healthy, but eating them is a choice.

Debra Gaines said she found a study that linked fluoride to cognitive difficulties, and questioned whether it contributed to the rising rates of obesity in the United States.

But Dr. Bruce Golden, a pediatric d...


Proponents ask North Marshall Utilities board to return fluoride to water supply "IndyWatch Feed Health"

MARSHALL COUNTY, AL (WAFF) Proponents are hoping a water utility in Marshall County will put fluoride back into the water system.

North Marshall Utilities ceased putting fluoride in the water system at the end of October.

A group of dentists and other health professionals appeared before the utilitys board Tuesday night to ask them to reconsider.

Julian Sparks, a retired dentist from Grant, was there and hopes their discussion was persuading.

They listened to what we had to say and I felt good after I left the meeting about their next meeting. I think theyll bring it up for a vote again and hopefully theyll vote to put the fluoride back in the water, said Sparks.

The board meets again Jan. 16 at 6:30 p.m.

*Original article online at

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Tuesday, 21 November


PFCS. State alleges 3M chemicals caused cancer and infertility, alleges $5 billion in damage "IndyWatch Feed Health"

Minnesota Attorney General Lori Swanson says toxic chemicals dumped by 3M Co. in the east metro suburb Oakdale caused higher rates of cancer, infertility and low birthweight babies the first time anyone has estimated the potential human health impact of groundwater contamination in the area since the problem came to light almost two decades ago.

In court briefs filed Friday, Swanson included the conclusions of an expert environmental witness, while alleging that the health and environmental damage of the contamination totals $5 billion and arguing that 3M should be liable for punitive damages.

The states lawsuit against 3M, first filed in 2010, is scheduled for trial early next year after a long series of procedural delays.

The new filings detail allegations that 3M knew the local groundwater was contaminated with chemical compounds known as PFCs years before it stopped making them; that it suppressed the information over the objections of its own scientists; and that it withheld critical information from the U.S. Environmental Protection Agency (EPA).

3M, in pursuit of profit, deliberately disregarded the substantial risk of injury to the people and environment of Minnesota from its continued manufacture of PFCs and its improper disposal, the state said.

In a statement Monday, 3M said Minnesota has not sustained any injuries, let alone over $5 billion in alleged damages.

3M believes these chemicals present no harm at the levels they are observed in Minnesota, said 3Ms lead attorney, William Brewer III.


The Death of Expertise "IndyWatch Feed Health"

In Tom Nichols' new book, The Death of Expertise, he explains how a misguided intellectual egalitarianism is harming our ability to assess the truth and solve problems, and discusses some of the responsible factors and possible long-term consequences.

Monday, 20 November

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