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Monday, 19 February


Red meat consumption was significantly positively associated with ferritin concentrations and myocardial infarction risk. "IndyWatch Feed Health"

PMID:  Am J Clin Nutr. 2018 Jan 1 ;107(1):113-119. PMID: 29381787 Abstract Title:  Red meat consumption and risk of cardiovascular diseases-is increased iron load a possible link? Abstract:  Background: High iron load and red meat consumption could increase the risk of cardiovascular diseases (CVDs). As red meat is the main source of heme iron, which is in turn a major determinant of increased iron load, adverse cardiometabolic effects of meat consumption could be mediated by increased iron load.Objective: The object of the study was to assess whether associations between red meat consumption and CVD risk are mediated by iron load in a population-based human study.Design: We evaluated relations between red meat consumption, iron load (plasma ferritin), and risk of CVD in the prospective EPIC-Heidelberg Study using a case-cohort sample including a random subcohort (n = 2738) and incident cases of myocardial infarction (MI, n = 555), stroke (n = 513), and CVD mortality (n = 381). Following a 4-step mediation analysis, associations between red meat consumption and iron load, red meat consumption and CVD risk, and iron load and CVD risk were assessed by multivariable regression models before finally testing to which degree associations between red meat consumption and CVD risk were attenuated by adjustment for iron status.Results: Red meat consumption was significantly positively associated with ferritin concentrations and MI risk [HR per 50 g daily intake: 1.18 (95% CI: 1.05, 1.33)], but no significant associations with stroke risk and CVD mortality were observed. While direct associations between ferritin concentrations and MI risk as well as CVD mortality were significant in age- and sex-adjusted Cox regression models, these associations were substantially attenuated and no longer significant after multivariable adjustment for classical CVD risk factors. Strikingly, ferritin concentrations were positively associated with a majority of classical CVD risk factors (age, male sex, alcohol intake, obesity, inflammation, and lower education).Conclusion: Increased ferritin concentrations may be a marker of an overall unfavorable risk factor profile rather than a mediator of greater CVD risk due to meat consumption.

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What Makes Mustard Spicy? "IndyWatch Feed Health"

By Dr. Mercola

Everyone has individual likes and dislikes, especially when it comes to heat in their food. Look at the menus at certain restaurants, for instance, and you might find tiny jalapeno icons next to certain dishes to signify their heat level. One jalapeno means mildly hot; five indicate as fiery as they can make it.

A perfect example of a food or rather a condiment thats very popular and comes in widely varying degrees on the heat index is mustard, which can definitely rival jalapenos in the heat index. Some like it hot, as the saying goes.

There are multiple varieties of mustard to satisfy your cravings, but have you ever wondered what provides the flavor and heat? Theres actually a plant known as mustard, a Brassica (or more scientifically, a Brassicaceae, sometimes referred to as mustards) correctly and its seed is the agent, in a matter of speaking, that supplies the spice.

In and of themselves, tiny, round mustard seeds arent hot or spicy. Its when theyre ground or broken open and mixed with liquid that the zing emerges. There are a few types of mustard seeds: white, brown and black. White mustard seeds produce heat on your tongue, but its the darker seeds that impart the pungent essence in your nose. This type of flavor is longer-lasting and more intense.

Thats why the traditional yellow mustard youre probably familiar with requires white mustard seeds, and the stronger varieties of this popular condiment come from using darker seeds. In fact, yellow mustard is the second most-used condiment in the U.S., no doubt because it works so well with so many types of meat as well as seafood. Experimenting with different types of mustards is a tasty way to get acquainted with all the different types.

Mustard: The Science Behind the Heat

One of the compounds in mustard seeds that imparts the aforementioned zing is called sinigren, a glucosinolate or natural constituent of pungent plants found in this Brassica veggie.

When sinigren is broken down, it emits an enzyme called myrosinase, and that in turn creates mustard oil. Its the oil that produces the heat when liquid is added, such as cold water. Its so strong that if you should attempt to make your own homemade mustard, the heat can burn and blister your skin. Savvy mustard makers wear protective gloves for this reason.

The process doesnt happen immediately. It takes about 15 minutes for the chemical process of turning up the heat to take place and reach its peak intensity. Because this intensity begins to rapidly diminish, the process of maki...

Weekly Health Quiz: Plants, Pollution and Digestion "IndyWatch Feed Health"

1 A potent adaptogen, this perennial plant has been shown to boost vitality and mood by modulating your immune function and enhancing nervous system health, and may offer powerful protection against burnout.

  • Rhodiola Rosea

    Rhodiola rosea is a powerful adaptogen known to enhance vitality by helping your body adapt to physical, chemical and environmental stress. Learn more.

  • Ginseng
  • Holy Basil
  • Rosemary

2 CDC Director Dr. Brenda Fitzpatrick resigned from her post a day after it was publicly revealed that she had bought stocks in:

  • Fracking industry
  • Tobacco industry

    Mere months into her new job as director of the CDC, Dr. Brenda Fitzgerald purchased stocks in a Japanese tobacco company, even though smoking is a leading cause of preventable death in the U.S. She resigned the day after her new investments were publicly exposed. Learn more.

  • Processed food industry
  • Soda industry

3 Which of the following industries has been identified as a major contributor to India's rapidly growing water pollution problem and a culprit in growing antibiotic-resistance?

  • Water treatment
  • Pharmaceutical

    Between 2010 and 2015, the number of contaminated waterways in India more than doubled, and the severe water pollution problem can be, to a...

Why This Meat Is so Healthy "IndyWatch Feed Health"

By Dr. Mercola

Even though grass fed and grain-finished beef sales have grown by 1,500 percent since 2012, according to ABC News, they are still overshadowed by conventional beef sales in the U.S., which topped $105 billion in 2015.1 While there is a long way to go before grass fed beef will become as popular as its conventional counterpart, the tides are changing as more consumers are demanding higher quality, safer meat products.

Once again, the health benefits of grass fed beef to both the consumer and the soil are making news. An ABC News feature highlights the success Texas farmers had in surviving a multiyear drought using regenerative agriculture practices and rotational grazing. The solution to their success was so simple and it can be applied anywhere: healthy soil + healthy grass = healthy grass fed beef.

Grass to the Rescue: Grass Fed Cows Save Drought-Stricken Texas Farms

As featured on ABC News Food Forecast program,2 the native grasses used to pasture grass fed beef is more than just animal feed its vital to the survival of both the soil and ranching way of life. Among those interviewed by program host Ginger Zee, chief meteorologist for ABC News, was cattle rancher Jon Taggart of Grandview, Texas, who has been raising grass fed and grass-finished cows for slaughter since 1999. To bring his meat to market, Taggart owns and operates three stores in Texas that sell pastured beef.

In 2011, as other ranchers watched feed grasses dry up and die when oppressive heat and drought gripped Texas, Taggart continued operating his business as usual. I'm proud to say we harvested cattle every week of the year through that entire drought, he told ABC News. The drought, by the way, lasted into 2015.

While millions of cattle were moved out of Texas to survive the heat and shortage of edible forage, Taggart did not destock a single animal, or turn to supplemental feeding. He attributes his success to the fact his farm was replete with what he calls those deep-rooted native grasses that were designed [to survive those droughts] by somebody a lot bigger than us.

After initially raising grain-finished cows meaning the animals, after starting a grass diet, were fed corn and other grains at the end of their lives as a means of increasing their size and weight just before slaughter Taggart and others began feeding their cows exclusively on grass. As you may imagine, feeding large herds of farm animals gras...

Magnesium One of the Most Important Nutrients for Heart Health "IndyWatch Feed Health"

By Dr. Mercola

Magnesium deficiency is extremely common, and recent research shows even subclinical deficiency can jeopardize your heart health. Magnesium is also important for brain health, detoxification, cellular health and function, and the optimization of your mitochondria. In short, magnesium has enormous potential to influence your health and general well-being, especially the prevention of heart disease and cancer, but also for general energy and athletic performance.

Why You Need Magnesium

Magnesium is the fourth most abundant mineral in your body and is involved in more than 600 different biochemical reactions. For example, magnesium plays an important role in:

Creation of adenosine triphosphate (ATP), the energy currency of your body1,2

Metabolism of calcium, potassium, zinc, phosphorous, iron, sodium, hydrochloric acid, acetylcholine and nitric oxide, as well as 300 enzymes and the activation of thiamine.3

Magnesium is also required for DNA, RNA and protein synthesis and integrity,4 and plays a role in the creation of chromosomes5

Mitochondrial function and health. Magnesium is required both for increasing the number of mitochondria in your cells and for increasing mitochondrial efficiency

Regulation of blood sugar and insulin sensitivity, which is important for the prevention of Type 2 diabetes6,...

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Sunday, 18 February


Knee Pain at Night: Causes and Natural Treatments "IndyWatch Feed Health"

Knee pain at night can affect people with various forms of arthritis or be caused by issues with nerves in the leg. The pain in your knees can be mild, dull aches that keep you awake at night. Or, you could have severe throbbing knee pain that causes you to wake up in the middle of the night.

Nighttime chronic knee pain can mean that you dont sleep well and it can make you tired and irritable the next day. Not getting enough sleep because of sharp pains in your knee can also have a knock-on effect on your knee pain. When you are well rested, your body deals with pain better.

There are some effective knee pain remedies that can help deal with pain in the legs at night. A warm compress or hot water bottle can help to relieve sharp knee pain by increasing circulation. Also, some remedies that include turmeric have pain-relieving properties and can help manage arthritis pain in your knees and joints.

So, what can you do if knee pain at night is keeping you awake and you cant get to sleep? In this article, you can find out what it means if one or both your knees hurt during the night. I will also discuss some ways that can help to get relief from knee pain discomfort.

Why Knees Can Ache at Night

Its not unusual for joint pain to get worse at night, and that includes your knees. According to Dr. Michael Schaefer, a specialist in musculoskeletal medicine and rehabilitation at the Cleveland Clinic, walking and moving helps to lubricate joints during the daytime. Knees can then start to ache at night because joints tend to swell when you stop moving.1

Dr. Schaefer points to another reason why you can get knee pain at night. Your sleeping position and body alignment can often cause pain in your knees, hips, and shoulders during the night. This is one reason why knee pain can get worse while you are sleeping.

Common Causes of Knee Pain at Night

Lets look in more detail at some of the common causes of knee pain while sleeping.


Osteoarthritis can cause sharp stabbing knee pains at night when you are resting in bed. The frequency and intensity of the night knee pain depend greatly on the extent of the osteoarthritis.

Researchers in the HSS Journal reported that there are a number of mechanisms that can contribute to nighttime knee pain. For example, minor injuries in the knee joint, damage to nerve fibers, or inflammation due to tissue damage could all be to blame for throbbing knee pain at night. Osteoarthritis suffers describe nighttime knee pain as anything from mild, dull aching to intense jabbing knee pain....


Do Criminals have more Rights than Parents in Tennessee? Local Media Covers Problem of Legal Kidnapping by State of Tennessee "IndyWatch Feed Health"

Fox17 Tori Tennessee

Image courtesy of Fox17 Nashville.

Comments by Brian Shilhavy
Editor, Health Impact News

We applaud and thank reporter Dennis Ferrier for exposing the injustice in Tennessees Juvenile Justice System, where he reports that serial killers have more rights than parents in Tennessee. Please click through to read his entire expose, and thank him for daring to cover this important topic.

For more on the unconstitutional practices of family courts nationwide that routinely remove children from parents against their will and against the principles of the U.S. Constitution, where a rapist, murderer, or terrorist has more rights in our judicial system than parents do in family courts, see:

Does the State Ever Have a Right to Remove Children from a Home?

FERRIER FILES: Do criminals have more rights than parents in Tennessee?

by Dennis Ferrier 
Fox17 Nashville


It is pretty hard to believe that serial killers have more rights than parents in Tennessee, but once you enter the Juvenile Justice System, anything can happen.

And even if you do absolutely nothing wrong, your children can be taken from you. It may sound like a ridiculous question but not when you consider what happened to a Williamson County, Tennessee, mom.

It all started when Toris 3-year-old son told her something inappropriate happened to him when he was wit...


Do Criminals have more Rights than Parents in Tennessee? Local Media Covers Problem of Legal Kidnapping by State of Tennessee "IndyWatch Feed Health"

Fox17 Tori Tennessee

Image courtesy of Fox17 Nashville.

Comments by Brian Shilhavy
Editor, Health Impact News

We applaud and thank reporter Dennis Ferrier for exposing the injustice in Tennessees Juvenile Justice System, where he reports that serial killers have more rights than parents in Tennessee. Please click through to read his entire expose, and thank him for daring to cover this important topic.

For more on the unconstitutional practices of family courts nationwide that routinely remove children from parents against their will and against the principles of the U.S. Constitution, where a rapist, murderer, or terrorist has more rights in our judicial system than parents do in family courts, see:

Does the State Ever Have a Right to Remove Children from a Home?

FERRIER FILES: Do criminals have more rights than parents in Tennessee?

by Dennis Ferrier 
Fox17 Nashville


It is pretty hard to believe that serial killers have more rights than parents in Tennessee, but once you enter the Juvenile Justice System, anything can happen.

And even if you do absolutely nothing wrong, your children can be taken from you. It may sound like a ridiculous question but not when you consider what happened to a Williamson County, Tennessee, mom.

It all started when Toris 3-year-old son told her something inappropriate happened to him when he was with t...


Federal Lawsuit Challenges Cannabis Scheduling "IndyWatch Feed Health"

Follow Us!Share This!A lawsuit challenging the current scheduling of cannabis had its first hearing in federal district court on February 14. The suit was filed by the father of Texas medical marijuana patient Alexis Bortell, former NFL player Marvin Washington, the father of medical marijuana patient Jagger Cotte, US Army veteran Jose Belen, and the Cannabis Cultural Association. The governments motion to dismiss was heard on Feb 14 by US District Court Judge Alvin Hellerstein. Hellerstein deferred his ruling on...
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Should you wet your toothbrush before brushing? Dentists give the definitive answer "IndyWatch Feed Health"


Dr Lisa Creaven of Spotlight Whitening also recommended wetting the toothbrush with warm water prior to brushing for a smoother brushing experience.

She told IBTimes UK: Although toothpaste contains water that will naturally foam the paste, lubricating the brush prior can make the brushing experience that bit more comfortable.

There is no right or wrong but again the more comfortable it is, the longer you are likely to brush for and that is whats important.

What is key, however, is not rinsing the mouth immediately after brushing, according to the NHS. Instead, simply spit out excess toothpaste.

Rinsing straight away will wash away the concentrated fluoride in the remaining toothpaste, thus diluting it and reducing its preventative effects.

*Original article online at


Left vs. Right Abdominal Pain and Back Pain In Men and Women: What Does It Mean? "IndyWatch Feed Health"

Abdominal pain and back pain are some of the most common types of pain in men and women. The pain can feel like dull aches in the left or right abdomen, or sharp, jabbing pains in your lower belly or pelvic area. Many women experience abdominal cramping and low back pain as part of their menstrual cycle. Its not unusual for the pain to radiate to other areas of your body. For example, pain could start in the middle of your back and spread to your flank or groin.

Many vital organs are located below your ribcage and around your belly that can cause pain if inflamed. For example, your digestive system, kidneys, liver, and heart can all be a source of abdominal pain and back pain. Along with abdominal pain and back pain, you may have other accompanying symptoms. For example, diarrhea, nausea, vomiting, abdominal tenderness, and unexplained weight loss can happen with abdominal pain.

Knowing the exact cause of left or right abdominal pain or back pain can be a challenge. However, finding out the reason for back pain or abdominal pain is important because it can be a sign of a serious medical condition. For example, the upper abdominal pain associated with heartburn can mimic heart attack pain. Or, lower right-side belly pain may be trapped gas or could be a symptom of appendicitis.

In this article, you will learn what it means if you have left abdominal pain, right abdominal pain, or back pain. You will also find useful advice on how to treat the pain and when you should see a doctor for your symptoms.

Right vs. Left Back Pain

Left or right back pain is a common condition that most of us will suffer from at some point. Muscle strain, poor posture, a herniated disc, and damage to the spine can all be a source of chronic back pain. This can result in sharp pains when moving, or dull constant aching in the lower back when sitting or standing for a long time. Many studies point to the fact that instances of chronic lower back pain are on the rise.

Also, women are affected more by back pain than men. A study from 2015 found that cases of chronic lower back pain in women are about 50% higher than in men.1 Changes during the menstrual cycle, ovulation, pregnancy, and fibroids can cause sharp, intermittent jabbing back pains.

The cause of left back pain or right back pain can often be determined by its location.

Upper Left Back Pain vs. Upper Right Back Pain

Your upper and middle back is the area of your back from the base of your neck to your lower ri...


Interested In Muscle? Eat Whole Eggs Rather Than Egg Whites "IndyWatch Feed Health"

Healthy EggsBy Natasha Longo

Egg yolks contain over 80 percent of the overall vitamins and minerals that can be found within the egg as a whole. The yolk also contains enzymes which help the body absorb the protein in the white. People who consume protein from whole eggs or from egg whites after engaging in exercise differ dramatically in how their muscles build protein, a process called protein synthesis, during the post-workout period, researchers report in a new study.

For years, this misunderstood food low in calories, containing every single vitamin (A, B, D, E, K) except C, and nearly perfect in protein was once shunned for threats to cholesterol intake.

Specifically, the post-workout muscle-building response in those eating whole eggs is 40 percent greater than in those consuming an equivalent amount of protein from egg whites, the team found.

The discovery, reported in the American Journal of Clinical Nutrition, suggests that the widespread practice of throwing away egg yolks to maximize ones dietary protein intake from eggs is counterproductive, said Nicholas Burd, a University of Illinois professor of kinesiology and community health who led the research. The USDA National Institute of Food and Agriculture Hatch project supported this research.

The yolks also contain protein, along with key nutrients and other food components that are not present in egg whites, Burd said. And something in the yolks is boosting the bodys ability to utilize that protein in the muscles.

Egg yolks actually contain all...


Lower Risk of Chronic Illness and Cognitive Decline by Going Keto "IndyWatch Feed Health"

By Anna Hunt

One of the fastest ways to lose weight and improve your health is by eating foods that induce the bodys state of nutritional ketosis. When this occurs, the body burns fat instead of sugar as its may source of energy, as well as producing beneficial ketone bodies. To reap the benefits of going keto, you can follow a simple formula of a ketogenic diet.

What is a Ketogenic Diet?

More people are realizing that dietary changes can have a profound impact on their health. Many proponents of healthy eating believe that diet alone can cure diseases like diabetes, obesity and high blood pressure. It definitely reduces your chances of having a chronic illness.

Where Big Pharma focuses on offering life-long treatments for chronic diseases, the goal of healthy nutrition is to reestablish balance in the body, thus eliminating disease. Many anecdotal stories have shown that making smart dietary choices has the potential to reverse some very serious illness.

Regardless of your state of health, a ketogenic diet can move you towards optimal health. The diet focuses on minimal carbohydrates and sugar, moderate amounts of protein, and high intake of healthy fats.

When we eat, we store our energy in form of glycogen in the liver. Glycogen is a molecule the body uses to store glucose. When we restrict the intake of carbohydrates and sugar, we deplete our glycogen storage....


Psychiatrys War on Free Will "IndyWatch Feed Health"

Since its birth around 1800, psychiatrys main role was to forcibly negate the free will of societys outliers. Its methods included forced removal, confinement, and electrical, surgical, and chemical lobotomy, as depicted in One Flew Over the Cuckoos Nest.1 Then psychiatry sought to expand its war on free will. So it devised ways to lure non-outliers into willingly allowing psychiatry to negate their free will, too.

First came a flanking attack that preyed upon the more trusting members of society:

Psychiatry vastly lengthened its list of learned coping styles and maturational stages that it called mental illnesses, and declared them to be involuntary brain diseases. This tricked many people into believing that theyre defective/incapable. They thus surrendered their freedom to choose how to address their or their kids challenges, and voluntarily handed this responsibility over to doctors. Giving up on themselves was reinforced by rewards like victim status, euphoria-giving (but brain-impairing/addictive) drugs, and lifelong disability benefits. Giving up on their kids was rewarded with instantly docile (sedated) kids who could slide through school without doing/learning much (via accommodations). People thereby further ceded control over their lives, and were trapped into eternal submissive dependence on psychiatry. Ka-ching!

Emboldened by its success, psychiatry then conducted an all-out assault on everybodys free will:

It began proclaiming that everyones free will is limited that variations in human coping styles are due to variations in how our brains are genetically hard-wired (neurotypes), which pre-fate us to develop fixed lifestyles. To persuade us to accept this myth, psychiatric neuroscientists search for the necessarily-present brain-activity correlates of thoughts, behaviors, or feelings, and then infer that these mental processes are caused by their physiological correlates. But thats illogical, since something cant cause itself to occur. Yet their false conclusions have misled many people to think that their coping habits are pre-determined and restricted, rather than freely chosen.

In truth, the essence of being human is that our huge brains have trillions of interconnections that give us freedom to flexibly learn and choose from among endless diverse ways to adapt. This gave us a big survival advantage over all other animals. And I dissected a human brain, so I can tell you it is soft/squishy like jelly; theres no hardwiring in there. Our brain processes dont control us; they are the means by which we control...


LISTEN: Dr. Tenpenny People Should Be Asking Questions And Taking Personal Responsibility "IndyWatch Feed Health"

Dr. Sherri Tenpenny took the airwaves this week to talk about draconian vaccine laws and peoples personal responsibility in the game of doctor visits. She encourages people to always ask questions about vaccines and take...

The post LISTEN: Dr. Tenpenny People Should Be Asking Questions And Taking Personal Responsibility appeared first on Vaxxter.


Green Banana Flour Blueberry Muffins Recipe "IndyWatch Feed Health"

green banana flour blueberry muffinsThe benefits of eating starchy green bananas is making lots of waves in the health community of late. While some diets demonize all things starch, the truth is that it can be a very nourishing food if you get the right kind. The classic blueberry muffins recipe below uses green banana flour for a delicious and easy way to get some into your familys diet! 


Best of: Break My Stride "IndyWatch Feed Health"

Note: Cathy has the weekend off. She wrote this post this time of year in 2014. By Cathy Jameson All I wanted to do on Thursday was vacuum. At 10pm, as I made my way to bed, I glanced over...


How Long Does It Actually Take to Bake Chicken? "IndyWatch Feed Health"

Chicken has been a staple food throughout the world for thousands of years. Its absolutely easy to cook, and can be paired with just about any ingredients to whip up a tasty and fulfilling meal. Whats more, organic pasture-raised chickens are rich in high-quality protein, and are also excellent sources of vitamins and minerals, including:[1],[2]


Pantothenic acid


How the TB12 Method Can Help You Achieve Peak Performance at Any Age "IndyWatch Feed Health"

By Dr. Mercola

In this interview, Alex Guerrero, cofounder of TB12 and personal body coach for Tom Brady one of the best quarterbacks in NFL history shares the natural and holistic program he developed with Brady, called the TB12 Method. Tom was told at one point that surgery for one of his injuries was unavoidable. This training method was said to have helped resolve his injury and return to the field, without surgery. 

The pair recently launched The TB12 Method mobile app on iOS, and co-wrote a New York Times best seller book about their philosophy, called The TB12 Method: How to Achieve a Lifetime of Sustained Peak Performance. A primary focus of the program is pliability training deep force muscle work that lengthens and softens muscles at the same time those muscles are rhythmically contracted and relaxed. 

I've been practicing this for a little over 20 years now, and when I first started, it was with the idea of just doing some good deep tissue work and helping athletes recover from whatever their injuries were at the time, Guerrero says.

Some of [my] clients would feel better and would go back out and do their training, and then they would hurt themselves again It became a pattern, and at some point I thought, I really need to see what this mechanism of injury really is. And why are they feeling better but not getting better?

As I started to watch them actually train, I realized that everything they were doing, all their biomechanical movements were all learned behavior. The brain was developing more neural pathways as it related to the way they were wanting to move. So, I thought our treatment principles should be based on the same thing.

And if the brain can create neural pathways based on functional movement, then I should be able to do some functional movement during my treatments so that the brain can create more neural pathways for getting better as opposed to just feeling better.

Pliability Training

As he began working on muscle tissues through active ranges of motion, and having the client actively involved in the movement, they not only felt better but actually stopped reinjuring themselves. Thats when he realized that being pliable is different from being flexible...


The Really Weird World Of Smart Meters "IndyWatch Feed Health"

By Catherine J. Frompovich

Probably when those who either question and/or oppose AMI Smart Meters thought the situation couldnt get any more weird than it is regarding misinformation and lack of transparency about the so-called consensus science that dominates technology, medicine, pharmacology and vaccines, the makers of one high-profile Smart Meter, Landis+Gyr seemingly has outdone itself.

The website Blacklisted News featured an article titled Smart Meter Company Landis+Gyr Now Using Copyright To Try To Hide Public Records. What happened to transparency, especially in high tech science? Is there information they dont want the public to know?

As some background information, back in 2016 L+G took some legal action, which was chronicled in the Tech Dirt article Smart Grid Company Demands MuckRock Turn Over Info On Anyone Who Might Have Seen Public Records Docs Involving It.



Letter | We should be looking closer at fluoride facts "IndyWatch Feed Health"

FELLOW residents, Im a little worried. Having waded through the National Health and Medical Research Councils (NHMRC) much-touted cornerstone documentation into fluoridation, Ive gone on to research a highly critical review of that reporting prepared by Merilyn Haines of Fluoride Action Network (FAN) Australia. Her review, written in August last year, has identified over 20 major issues that bear greater scrutiny if this 2017 reporting by the NHMRC is be taken seriously by decision-makers. FAN is publicly calling for a Royal Commission into the NHMRC as a result. Dont shoot the messenger.

If these NHMRC products are what state health, the Oberon Health Council and other parties are relying on to push the fluoridation agenda, then I feel there is good reason to worry.  Ignoring established and new scientific data because it fails to pass obviously restrictive entry criteria only fuels the counter-narrative and adds to suspicion; particularly when it is irrefutable data that does not support the official agenda. Theres something definitely not right about this whole affair and decision-makers should carefully consider their next move. The legal repercussions alone should cause concern. If you can chew through it, Mr Mills, and find me a reason not to worry, Ill buy the first two rounds.

The old paradigm of innocuously adding a heavily propagandised industrial waste product to the water supply to medically treat the unwitting population has clearly run its course; as it already has for arsenic, mercury, barium and lead (all of which comes with industrial grade fluoride). The official product S6 Fluorocilic Acid [H2SiF6] and DiSodium Hexafluorosilicate [Na2SiF6] should not be in our bodies at any level. Its useful on the teeth as pharmaceutical grade fluoride only, then spat out! Thats it! (Hint: Poison warning on tube.) Trace amounts, dear people. It accumulates. Nothing nutritious or good about any of these waste products in the body. Time for us all to collectively face the music. Arent we sick enough? When we dwell in truth things only get better.

Chris Freeman

*Original letter published online at

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Saturday, 17 February


Letters to the editor Letter: Citizens should educate themselves on fluoride "IndyWatch Feed Health"

To the editor:

As a dentist with an undergraduate degree in comparative biochemistry and physiology, 30 years studying toxicology, author of a book on preventive dentistry and producer director of 30 public awareness programs as well as a co-author of the International Academy of Oral Medicine and Toxicology (IAOMT) position paper Overexposure to fluoride from all sources, I am heartened by the number of concerned citizens who are referring that IAOMT paper to their city officials. We spent a lot of time and effort to use only the best evidence and lay out our concerns as clearly and in as much detail as we felt the subject needed to fully communicate the impact of systemic exposure to fluoride. The accuracy of the document speaks for itself since its release five months ago not one statement of fact has been refuted. The IAOMT is a nonprofit association of dentists, physicians, research scientists and care providers dedicated to the mission of safe dentistry. The IAOMT was founded in 1984 to address the growing professional awareness with peer-reviewed scientific evidence that many of the commonly used materials in dentistry have an adverse impact on health. Our mission is professional education and public awareness. However, it is only natural that citizens such as Karen Spencer, Linda Wrinn, Lin Chandler and Damon Cummings of Gloucester, Jessica McGovern and Mary Hart Lenhardt of Manchester, and Alan MacMillan of Rockport would find our work useful for beginning conversations with decision makers in their communities. I commend them for their diligent commitment to supporting modern science and public health.

The first question I encourage every responsible decision maker to ask is, how much fluoride from optimally fluoridated municipal water is safe for a bottle-fed infant?

I urge the city leaders in Gloucester, Rockport and Manchester to read the IAOMT position paper and talk to their own knowledgeable citizens; 21st century science has found fluoridated water carries substantial risks and has minimal if any benefits.

DAVID KENNEDY San Diego, California

*Original letter online at



Fluoridation debate continues in Clark County "IndyWatch Feed Health"

City officials in central Ohio are considering fluoridating the municipal water supply to combat poor dental health.

The Springfield News-Sun reports Clark County Health Commissioner Charles Patterson urges Springfield city commissioners to allow a referendum vote in November on fluoridating the water supply.

A state Department of Health study says about two-thirds of children in Clark County has experienced tooth decay. Patterson says the chief complaint among patients at Springfield Regional Medical Centers emergency room in 2015 was oral health-related pain.

Patterson says fluoridation is safe and the most effective way to prevent oral health decay.

Opponents of the measure say fluoridation is harmful and the county should instead focus on expanding dental coverage for Medicaid patients.

Ballot initiatives for the November election must be filed by Aug. 8.


Protesters call for ban of modified hydrofluoric acid at Torrance refinery "IndyWatch Feed Health"

If that very heavy piece of equipment had gone 5 feet farther, the accident would have released a toxic ground-hugging cloud that could kill people all the way to the beach, said Sally Hayati, with the Torrance Refinery Action Alliance.

The refinery is aware of the communitys concerns. In a statement, the company said the explosion occurred under a previous owner.

Since acquiring the refinery on July 1, 2016, we have been investing in our people, plant and processes to improve the overall safety, reliability and performance, it said.

Protesters said they want the refinery to replace MHF with a less dangerous chemical.

Theres no acceptable level of likelihood for a release of hydrofluoric acid. The consequence is just too great to let there be any chance of having this happen, Vollbracht said.

The refinery said it continues to work closely with the South Coast Air Quality Management District.

*TV report and original article online at


Protesters rally to mark third anniversary of explosion at Torrance refinery "IndyWatch Feed Health"

A coalition of sign-wielding environmental activists on Saturday marked the third anniversary of the Feb. 18, 2015, explosion at the Torrance refinery that federal officials said nearly caused a catastrophic release of highly toxic hydrofluoric acid that could have killed and injured thousands. Led by grass-roots group the Torrance Refinery Action Alliance, hundreds of protesters gathered at Columbia Park to renew their call for a ban on the toxic chemical and marched en masse to the nearby refinery on 190th Street.

  • Prior to marching to protest at the PBF Energy refinery, people gather signs at Columbia Park in Torrance on Saturday, Feb 17, 2018. It has been three years since the refinery explosion rocked the neighborhood and now residents are calling for a ban on the use of hydrofluoric acid at the refinery. (Photo by Scott Varley, Contributor)
  • ...


6 Bodily Tissues That Can Be Regenerated Through Nutrition "IndyWatch Feed Health"

6 Bodily Tissues That Can Be Regenerated Through Nutrition

It may come as a surprise to some, especially those with conventional medical training, but the default state of the body is one of ceaseless regeneration.  Without the flame-like process of continual cell turnover within the body life and death ceaselessly intertwined the miracle of the human body would not exist.

In times of illness, however, regenerative processes are overcome by degenerative ones. This is where medicine may perform its most noble feat, nudging the body back into balance with foods, herbs, nutrients, healing energies, i.e. healing intention. Today, however, drug-based medicine invariably uses chemicals that have not one iota of regenerative potential; to the contrary, they almost always interfere with bodily self-renewal in order to suppress the symptoms against which they are applied.

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Age of Reactive Attachment Disorder? "IndyWatch Feed Health"

Our community is none too pleased to see reports that the Florida shooter "may have had autism." Our children, from tots to teens to twenties and beyond, are not innately cruel. They may be terribly violent at times most often...


New Utah Law Would Expand Raw Milk Sales From Farms and Markets to Mobile Trucks "IndyWatch Feed Health"

By Michael Maharrey

Yesterday, a Utah Senate committee passed a bill would expand raw milk sales in the state. Passage into law would take an important step toward rejecting a federal prohibition scheme in effect.

Sen. David Hinkins (R-27) and Rep. Marc Roberts (R-67) introduced Senate Bill 108 (SB108) January 23. The legislation would expand existing laws relating to raw milk sales from producer to consumer in the state. Under the proposed law, a milk producer would be able to sell up to 120 gallons of raw milk per month to consumers without meeting stricter requirements under the current law and permitting program, providing certain conditions are met. Under the proposed law, the raw milk could only be sold directly to the consumer on the premises where the milk is produced for household use, not resale. SB108 also includes handling, sanitation and record-keeping requirements for unlicensed producers of raw milk. The milk bottle would have to include the warning This raw milk has not been licensed or inspected by the state of Utah. Raw milk, no matter how carefully produced, may be unsafe.

The proposed law would also allow licensed producers to sell raw milk from a mobile refrigerated truck where the raw milk is maintained at 41 degrees Fahrenheit or a lower temperature.

The Senate Natural Resources, Agriculture, and Environment Committee...


Prevention Against Gallstones Eat More Foods With Vitamin E "IndyWatch Feed Health"

By Karen Foster

More than 90 percent of the population does not meet their recommended daily allowance of vitamin E. Researchers in Germany led by the University of Kiel found that subjects with gallstone disease had lower blood levels of vitamin E than those who did not have gallstones.

Gallstones are hardened deposits of digestive fluid that can form in your gallbladder. Gallstones range in size from as small as a grain of sand to as large as a golf ball. Some people develop just one gallstone, while others develop many gallstones at the same time. Most gallstones provoke no symptoms at all. On average, symptoms take about eight years to develop.

Vitamin E does everything from ease exercise soreness, treating menstrual pain, preventing cancer and playing a central role in neurological and cardiovascular function. Adequate levels of vitamin E, an essential micronutrient, are especially critical for the very young.

The scientists also found that those with gallstone disease also had a lower alpha-tocopherol/cholesterol ratio than healthy individuals. A similar association was found with gamma-tocopherol levels. However, with the gamma form, the results were not statistically significant.

We observed an inverse association between circulating vitamin E (alpha- and gamma-tocopherol [non-significant]) levels and the prevalence of gallstone diseas...


NJ Hospital Says More Flu Shots Key To Immune System "IndyWatch Feed Health"

Its the flu season that simply wont go away. Many people are questioning how hospital workers, such as nurses, are surviving. One New Jersey hospital claims that the more flu shots you get, the better...

The post NJ Hospital Says More Flu Shots Key To Immune System appeared first on Vaxxter.


The REAL STORY About the Skeptic Attack on Del BigTree "IndyWatch Feed Health"

Are We Sick of The Threats, Lies and Misdirection? Opinion by Deplorable Consumer Advocate Tim Bolen The photo at the top of this article is indeed worth a thousand words, for it explains a lot about WHO, and WHAT, attacked Vaxxed producer Del BigTree. Lets explore that WHO, and WHAT.  Yes, the attack was easily repulsed Continue reading The REAL STORY About the Skeptic Attack on Del BigTree

The post The REAL STORY About the Skeptic Attack on Del BigTree appeared first on BolenReport.


Statement of APA President in Response to Florida Shooting "IndyWatch Feed Health"

APA President Jessica Henderson Daniel has released a statement on the recent school shooting in Florida emphasizing the lack of correlation between gun violence and mental health.

While law enforcement is still piecing together the shooters motives, some public figures and news reports are focusing on his mental health. It is important to remember that only a very small percentage of violent acts are committed by people who are diagnosed with, or in treatment for, mental illness. Framing the conversation about gun violence in the context of mental illness does a disservice to the victims of violence and unfairly stigmatizes the many others with mental illness. More important, it does not direct us to appropriate solutions to this public health crisis.



When You Start Paying Attention to Everyday Sensory Experience "IndyWatch Feed Health"

From Aeon: A new video aims to capture the small, abstract moments that make up our inner lives, that would otherwise go ignored or quickly disappear.



Michael Fontaine: What the Ancient World Can Teach Us About Emotional Distress "IndyWatch Feed Health"

This week on MIA Radio, we interview Professor Michael Fontaine. Michael is Professor of Classics and Associate Vice Provost of Undergraduate Education at Cornell University in New York. He regularly consults on Latin for museums, institutions, dealers, and collectors, having exposed forgery in Renaissance and Dutch Golden Age paintings. In 2016 he received the Thomas S. Szasz Award for Outstanding Contributions to the Cause of Civil Liberties.

In the episode we discuss:

  • How Michael came to be a Professor of Classics and Literature.
  • How studying the ancient world helps us to understand what the first scientists thought about mental or emotional distress.
  • The first use of the phrase psychiatric ward which can be found at the Library of Alexandria in Northern Egypt.
  • That the phrase that ultimately became the word Psychiatry in ancient times actually meant a Healing Place for the Soul and is inscribed above library entrances even today ( or Psyches iatreion).
  • The links between the Rosenhan experiment and a comedic play written 2,200 years ago by the ancient Roman playwright T. Maccius Plautus.
  • That, in the ancient world, there was no long-term incarceration in prisons or asylums.
  • The relationship between the Hippocratic/medical model (the humoral theory) and the Epicurean model of mental or emotional distress.
  • That, in the ancient world, depression didnt exist, and that the solutions for unhappiness were based in the community or in Philosophy.
  • That about 1700 years ago, the Roman Empire entered a state of decline and it...


Congress Did Something Extraordinary for Vulnerable Children "IndyWatch Feed Health"

From The Intercept: A new piece of legislation attempting to revolutionize the foster care system recently passed despite significant opposition. The Family First Prevention Services Act allows states to use federal funds for preventative mental health and substance use programs to keep at-risk children in their homes instead of the foster system.

The Family First Prevention Services Act will usher in the most significant improvements to the child welfare system in decades and provide real help to families to fight the opioid epidemic, Wyden said in a statement. We owe our most vulnerable children the best chance to stay with their families when its safe to keep them at home and the highest standards of care to protect children who are already in foster care.

Children are taken from their families in cases of abuse but more often than not, Sandy Santana, executive director for Childrens Rights, said, kids enter the foster care system because of neglect that stems primarily from issues of poverty or substance abuse.

With the opioid epidemic, more and more kids are coming into the system because their parents are dependent on opioids, Santana said. For the government now to redirect funding for substance abuse and preventative services to keep those kids that are at risk of entering foster care with their families is a big, big deal.'



Pharmagunndon in America "IndyWatch Feed Health"

Note: Teresa Wrote this post in 2012, after the shooting by Adam Lanza in Newtown, CT. Seems this post should just be "on deck" at any given moment in the USA. By Teresa Conrick Here at Age of Autism, we...


Dietary phytoestrogens are associated with lower likelihood of hypertension in adults living in the Mediterranean area. "IndyWatch Feed Health"

PMID:  Molecules. 2018 Feb 9 ;23(2). Epub 2018 Feb 9. PMID: 29425149 Abstract Title:  Dietary Phytoestrogen Intake is Inversely Associated with Hypertension in a Cohort of Adults Living in the Mediterranean Area. Abstract:  BACKGROUND: Dietary polyphenols, including phytoestrogens are abundantly present in a balanced diet. Evidence for their role in preventing non-communicable diseases is emerging.METHODS: We examined the association between estimated habitual intakes of dietary phytoestrogens and hypertension in a cohort study. The baseline data included 1936 men and women aged 18 years and older. Intakes of total phytoestrogens, isoflavones, and lignans were calculated from validated food frequency questionnaire. Data on the polyphenols content in foods were retrieved from the Phenol-Explorer database.RESULTS: Individuals in the highest quartile of dietary phytoestrogens intake were less likely to be hypertensive (OR: 0.66, 95% CI: 0.44-0.98); moreover, the association showed a significant decreasing trend. Isoflavones and lignans were not associated with lower odds of hypertension; however, some individual compounds, such as biochanin A and pinoresinol showed an independent inverse association with hypertension.CONCLUSIONS: Dietary phytoestrogens are associated with lower likelihood of hypertension in adults living in the Mediterranean area. Future studies are needed to confirm the present findings (i.e., prospective cohort studies) and to better understand the mechanisms underlying such associations.

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Med-Diet adherence might potentially delay the onset of age-related health deterioration and reduce the need of multiple medications. "IndyWatch Feed Health"

PMID:  J Nutr Health Aging. 2018 ;22(1):73-81. PMID: 29300425 Abstract Title:  Aging and Adherence to the Mediterranean Diet: Relationship with Cardiometabolic Disorders and Polypharmacy. Abstract:  OBJECTIVES: To investigate the association between adherence to the Mediterranean Diet (Med-Diet), cardiometabolic disorders and polypharmacy.DESIGN: Cross-sectional study.SETTING: Geriatrics outpatient clinic, Policlinico Umberto I, Sapienza University of Rome.PARTICIPANTS: 508 patients (219 male, 289 female) aged 50 to 89 who were evaluated for cardiovascular and metabolic disorders.METHODS AND MEASUREMENTS: Patients underwent a comprehensive medical assessment including medical history and the use of medications. Adherence to Med-Diet was assessed using the validated Med-Diet 14-item questionnaire; for the analysis, patients were divided in high (8) and medium-low (

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Pumpkin seed oil prevents the high fat diet induced obesity by altering the markers important to lipid metabolism. "IndyWatch Feed Health"

PMID:  Nat Prod Res. 2017 Oct 19:1-4. Epub 2017 Oct 19. PMID: 29047298 Abstract Title:  Anti obese potential of Cucurbita maxima seeds oil: effect on lipid profile and histoarchitecture in high fat diet induced obese rats. Abstract:  In this study, we made an attempt to evaluate the potential of Cucurbita maxima seeds oil (CSO) against high-fat diet (HFD)-induced obesity in rats. We investigated the effect of CSO (100 mg/kg body weight) supplementation over 30 days on the changes of HFD-induced obese rats in body weight, biochemical parameters and lipid profile as well as investigated the effects of CSO on the histopathological changes. Oral administration with CSO revealed significant diminution in body weight gain, glucose and insulin levels, which altered the activity of lipid profile and restored the pathological alterations. It demonstrated that CSO had considerably altered these parameters when evaluated with HFD control rats. In conclusion, this study established that CSO prevents the HFD-inducedobesity by altering the markers important to lipid metabolism.

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Dietary supplementation with almonds may have a beneficial effect in reducing the risk of oxidative stress-induced memory loss. "IndyWatch Feed Health"

PMID:  Plant Foods Hum Nutr. 2018 Feb 10. Epub 2018 Feb 10. PMID: 29429075 Abstract Title:  Dietary Supplementation of Almond Prevents Oxidative Stress by Advocating Antioxidants and Attenuates Impaired Aversive Memory in Male Rats. Abstract:  Scopolamine, an anti-muscarinic agent, has been shown to induce amnesia and oxidative stress similar to that observed in the older age. The present study was designed to determine the relationship between the oxidative status and memory improvement in scopolamine injected rats pre-administered with almonds. Rats (n=8) in the almond group were administered orally with 400 mg/kg almond suspension for 28 days daily before the intraperitoneal injection of scopolamine (0.5 mg/kg). Passive avoidance task (PAT) was used to assess memory function at the end of treatment. The present study revealed that scopolamine injection significantly impaired the memory function in rats pre-treated with saline which was accompanied by increased oxidative stress as evident by increased brain malondialdehyde (MDA) levels and reduced activities of antioxidant enzymes as compared to healthy controls. Pre-treatment withalmond significantly ameliorated scopolamine-induced oxidative stress and memory dysfunction. These findings suggest that dietary supplementation with almonds may have a beneficial effect in reducing the risk of oxidative stress-induced memory loss and delaying or preventing the onset of age-related memory impairment.

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A carotenoid extract from a cultivar of pumpkin triggers nonprotective autophagy in malignant cells. "IndyWatch Feed Health"

PMID:  Oxid Med Cell Longev. 2017 ;2017:7468538. Epub 2017 Dec 21. PMID: 29430284 Abstract Title:  A Carotenoid Extract from a Southern Italian Cultivar of Pumpkin Triggers Nonprotective Autophagy in Malignant Cells. Abstract:  Carotenoids, including-carotene, lycopene, and derivatives, such as retinoic acid, have been studied for their significant antiproliferative and differentiating activity on cancer cells in experimental models and in clinics. We are presenting here data on the mechanism of action of a carotenoid-enriched extract obtained from the pumpkin, variety"long of Naples,"on two malignant human cell lines, Caco-2 and SAOs, derived from a colon adenocarcinoma and an osteosarcoma, respectively. The carotenoid extract has been obtained from pumpkin pulp and seeds by supercritical COextraction and employed to prepare oil-in-water nanoemulsions. The nanoemulsions, applied at a final carotenoid concentration of 200-400g/ml, were not cytotoxic, but induced a delay in cell growth of about 40% in both SAOs and Caco-2 cell lines. This effect was associated with the activation of a"nonprotective"form of autophagy and, in SAOs cells, to the induction of cell differentiation via a mechanism that involved AMPK activation. Our data suggest the presence of a pool of bioactive compounds in the carotenoid-enriched extract, acting additively, or synergistically, to delay cell growth in cancer cells.

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nuts and peanut butter might reduce pancreatic cancer risk in men. "IndyWatch Feed Health"

PMID:  Cancer Epidemiol Biomarkers Prev. 2018 Jan 22. Epub 2018 Jan 22. PMID: 29358224 Abstract Title:  Total nut, tree nut, peanut, and peanut butter consumption and the risk of pancreatic cancer in the Netherlands Cohort Study. Abstract:  BACKGROUND: Nut intake has been associated with decreased cancer-related mortality, but few studies have examined the potential of nuts in the chemoprevention of pancreatic cancer. We prospectively investigated the association of total nut, tree nut, peanut, and peanut butter consumption with pancreatic cancer risk.METHODS: In the Netherlands Cohort Study, 120,852 men and women completed a baseline questionnaire, including a food frequency questionnaire, in 1986. After 20.3 years of follow-up, 583 incident pancreatic cancer cases, including 349 microscopically confirmed pancreatic cancer (MCPC) cases, were included in multivariable case-cohort analyses.RESULTS: Increased total nut consumption was associated with a non-significantly decreased MCPC risk in men (HR (95% CI) for 10+ g/day vs. nonconsumers = 0.72 (0.47-1.11), P-trend = 0.163). No clear association was found in women. For tree nut and peanut consumption, non-significant inverse associations were observed in men. In women, no or unclear associations were found for tree nut and peanut consumption. Peanut butter intake was related to a significantly reduced risk of MCPC in men (HR (95% CI) for 5+ g/day vs. nonconsumers = 0.53 (0.28-1.00), P-trend = 0.047), but this relation was not clear in women. Evidence for a nonlinear dose-response relation with MCPC was found for tree nut intake only. The associations were weaker when looking at total pancreatic cancer.CONCLUSIONS: Our results suggest that nuts and peanut butter might reduce pancreatic cancer risk in men. In women, no or unclear associations were found.IMPACT: Nut consumption might reduce the risk of pancreatic cancer in men.

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These results confirm the effects of lipid-lowering and modifying body composition of almond consumption. "IndyWatch Feed Health"

PMID:  J Med Food. 2018 Jan 9. Epub 2018 Jan 9. PMID: 29315019 Abstract Title:  Time and Intervention Effects of Daily Almond Intake on the Changes of Lipid Profile and Body Composition Among Free-Living Healthy Adults. Abstract:  Favorable health benefits of almond have been shown in several previous studies. However, repeated measures, randomized, controlled trials to investigate the changes due to almond intake based on the time effects have not yet been reported. The current study was conducted to evaluate the effects of daily almond intake on changes in body composition and lipid profiles for 20 weeks with four measurements among healthy adults. Participants in the almond group showed favorable changes on blood lipid profiles, including levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and non-high-density lipoprotein (non-HDL-C) after consuming 56g of almond per day for 20 weeks compared with those at baseline. At week 20, subjects in the almond group showed significantly decreased TC, LDL-C, non-HDL-C, TG, body fat mass, and waist-hip ratio compared with those of the control group who consumed isocaloric control food. The mixed model also confirmed that there were significant time effects in several bioimpedance indicators (i.e., total body protein, fat-free mass, etc.) and all of the lipid profile parameters in the almond group. These results confirm the effects of lipid-lowering and modifying body composition of almond consumption. In addition, our results suggest that the measuring time points would be critical to capture the effects of dietary intervention.

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These results reveal that almond consumption induced changes in the microbial community composition of the human gastrointestinal microbiota. "IndyWatch Feed Health"

PMID:  Nutrients. 2018 Jan 26 ;10(2). Epub 2018 Jan 26. PMID: 29373513 Abstract Title:  Almond Consumption and Processing Affects the Composition of the Gastrointestinal Microbiota of Healthy Adult Men and Women: A Randomized Controlled Trial. Abstract:  BACKGROUND: Almond processing has been shown to differentially impact metabolizable energy; however, the effect of food form on the gastrointestinal microbiota is under-investigated.OBJECTIVE: We aimed to assess the interrelationship of almond consumption and processing on the gastrointestinal microbiota.DESIGN: A controlled-feeding, randomized, five-period, crossover study with washouts between diet periods was conducted in healthy adults (= 18). Treatments included: (1) zero servings/day of almonds (control); (2) 1.5 servings (42 g)/day of whole almonds; (3) 1.5 servings/day of whole, roasted almonds; (4) 1.5 servings/day of roasted, chopped almonds; and (5) 1.5 servings/day of almond butter. Fecal samples were collected at the end of each three-week diet period.RESULTS: Almond consumption increased the relative abundances of,, and( 0.05). Comparisons between control and the four almond treatments revealed that chopped almonds increased,, andcompared to control (

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Cashew nut supplementation in Asian Indians with T2DM reduced systolic blood pressure and increased HDL cholesterol concentrations. "IndyWatch Feed Health"

PMID:  J Nutr. 2018 Jan 1 ;148(1):63-69. PMID: 29378038 Abstract Title:  Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: A 12-Week Randomized Controlled Trial. Abstract:  Background: There is increasing evidence that nut consumption decreases the risk of cardiovascular disease. However, there are few data on the health effects of cashew nuts among adults with type 2 diabetes (T2DM).Objective: The study aimed to investigate the effects of cashew nut supplementation on glycemia, body weight, blood pressure, and lipid profile in Asian Indians with T2DM.Methods: In a parallel-arm, randomized controlled trial, 300 adults with T2DM [mean SD age: 51 9.3 y; body mass index (BMI; in kg/m2): 26.0 3.4; 55% male] were randomly assigned to receive advice to follow a standard diabetic diet (control) or similar advice plus 30 g cashew nuts/d (intervention) for 12 wk. The macronutrient composition of the prescribed diabetic diet was60-65% energy from carbohydrates, 15-25% from fat, and the rest from protein. Differences between groups in changes in anthropometric and biochemical variables were analyzed using linear models with robust variance estimation under an assumed independence working correlation.Results: Participants in the intervention group had a greater decrease in systolic blood pressure from baseline to 12 wk than did controls (-4.9 13.7 compared with -1.7 11.6 mm Hg; P = 0.04) and a greater increase in plasma HDL cholesterol compared with controls (+1.7 5.6 compared with +0.1 4.6 mg/dL; P = 0.01). There were no differences between the groups with respect to changes in body weight, BMI, blood lipid, and glycemic variables. Plasma oleic acid concentrations and self-reported dietary intake of nuts, oleic acid, and monounsaturated fatty acids suggested excellent compliance with the nut consumption.Conclusion: Cashew nut supplementation in Asian Indians with T2DM reduced systolic blood pressure and increased HDL cholesterol concentrations with no deleterious effects on body weight, glycemia, or other lipid variables. This study was registered at the clinical trial registry of India as CTRI/2017/07/009022.

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The findings indicate that the nut consumption may contribute to the delay of cognitive decline in aging. "IndyWatch Feed Health"

PMID:  Curr Alzheimer Res. 2018 Feb 1. Epub 2018 Feb 1. PMID: 29422003 Abstract Title:  Role of Nut Consumption in the Management of Cognitive Decline - A Mini-Review. Abstract:  BACKGROUND: Currently, there is a significant increase in the number of older generation groups, which may result in serious economic and social issues. Therefore there is a need to prolong the active life of these older individuals, especially by focusing on modifying lifestyle factors such as healthy nutrition. In fact, recent research has shown that, for example, nuts are an important part of people's healthy diet because they have appeared to be neuroprotective compounds which might maintain or in some cases even improve people's cognitive functions.OBJECTIVE: The purpose of this review study is to explore the role of the nut nutrition in the maintenance and delay of cognitive decline among older individuals.RESULTS: The findings indicate that the nut consumption may contribute to the delay of cognitive decline in aging. However, this nut diet is just one component of the multi-nutrient dietary intervention for health aging.CONCLUSION: More longitudinal controlled randomized studies have to be performed in this field to prove the efficacy of the nut nutrition for the delay of cognitive decline.

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Nephroprotection of plantamajoside in rats treated with cadmium. "IndyWatch Feed Health"

PMID:  Environ Toxicol Pharmacol. 2015 Jan ;39(1):125-36. Epub 2014 Nov 30. PMID: 25499790 Abstract Title:  Nephroprotection of plantamajoside in rats treated with cadmium. Abstract:  Cadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Plantamajoside (PMS), a major compound of Plantago asiatica (PA), was reported to have the antioxidant effects. In this study, we investigated the protective effects of PMS on Cd-induced renal damage in the NRK-52E cell and rat kidney tissue. Cd exposure increased the ROS generation, lipid peroxidation, serum biochemical values of renal damage, and mRNA and protein expressions of KIM-1 in vitro and in vivo. The significant reduction in glutathione (GSH)/glutathione disulfide (GSSG) ratio and activities of antioxidant enzymes were also observed in the rats treated with Cd. PMS significantly decreased the ROS generation and lipid peroxidation, thus enhancing GSH/GSSG ratio, antioxidant enzyme activities in the cells and rats, and improved histochemical appearances, indicating that PMS has protective activities against Cd-induced renal injury.

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Plantamajoside inhibits UVB and advanced glycation end products-induced MMP-1 expression. "IndyWatch Feed Health"

PMID:  Photochem Photobiol. 2016 09 ;92(5):708-19. Epub 2016 Aug 9. PMID: 27346084 Abstract Title:  Plantamajoside Inhibits UVB and Advanced Glycation End Products-Induced MMP-1 Expression by Suppressing the MAPK and NF-B Pathways in HaCaT Cells. Abstract:  Photoaging and glycation stress are major causes of skin deterioration. Oxidative stress caused by ultraviolet B (UVB) irradiation can upregulate matrix metalloprotease 1 (MMP-1), a major enzyme responsible for collagen damage in the skin. Advanced glycation end products (AGEs) accumulate via gradual formation from skin proteins, especially from long-lived proteins such as dermal elastin and collagen. Plantamajoside (PM), isolated from Plantago asiatica, has various biological effects including anti-inflammatory and antioxidant effects. In this study, we assessed the protective effects of PM on a human keratinocyte cell line (HaCaT) and primary human dermal fibroblasts (HDF) against stress caused by glyceraldehyde-induced AGEs (glycer-AGEs) with UVB irradiation. We found that PM attenuated UVB- and-glycer-AGEs-induced MMP-1 expression in HaCaT and HDF cells and proinflammatory cytokines expression by inhibiting the phosphorylation of mitogen-activated protein kinases (MAPKs) activated by reactive oxygen species. Specific inhibitors of NF-B and MAPKs attenuated the induced expression of MMP-1. PM also inhibited the phosphorylation of IB, and reduced nuclear translocation of NF-B in these cells. Furthermore, PM attenuated the upregulation of receptor for AGEs (RAGE) by glycer-AGEs with UVB irradiation. Therefore, our findingsstrongly suggest that PM is a promising inhibitor of skin photoaging.

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Antioxidant-rich extract from plantaginis semen Ameliorates diabetic retinal injury in a streptozotocin-induced diabetic rat model. "IndyWatch Feed Health"

PMID:  Nutrients. 2016 Sep 18 ;8(9). Epub 2016 Sep 18. PMID: 27649243 Abstract Title:  Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model. Abstract:  Plantaginis semen, the dried ripe seed of Plantago asiatica L. or Plantago depressa Willd. (Plantaginaceae), has been traditionally used to treat blurred vision in Asia. The aim of this work was to investigate the effect of plantaginis semen ethanol extract (PSEE) on the amelioration of diabetic retinopathy (DR) in streptozotocin (STZ)-diabetic rats. PSEE has abundant polyphenols with strong antioxidant activity. PSEE (100, 200 or 300 mg/kg) was oral administrated to the diabetic rats once daily consecutively for 8 weeks. Oral administration of PSEE resulted in significant reduction of hyperglycemia, the diameter of the retinal vessels, and retinal vascular permeability and leukostasis in diabetic rats. In addition, PSEE administration increased the activities of superoxidase dismutase (SOD) and catalase (CAT), and glutathione peroxidase (GSH) level in diabetic retinae. PSEE treatment inhibited the expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor-1 (HIF-1) and the phosphorylation of Akt without altering the Akt protein expression in diabetic retinae. PSEE not only down-regulated the gene expression of hypoxia-inducible factor-1 (TNF-) and interleukin-1 (IL-1), but also reduced ICAM-1 and VCAM-1 expression in diabetic retinae. Moreover, PSEE reduced the nuclear factor-B (NF-B) activation and corrected imbalance between histone deacetylases (HDAC) and histone acetyltransferases (HAT) activities in diabetic retinae. In conclusion, phenolic antioxidants extract from plantaginis semen has potential benefits in the preventionand/or progression of DR.

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The Motivation Factor "IndyWatch Feed Health"

By Dr. Mercola

Research1 has convincingly demonstrated that the more physically active children and teenagers are, the better they do academically. As noted by the authors of a 2012 scientific review:

"Physical activity and sports are generally promoted for their positive effect on children's physical health There is also a growing body of literature suggesting that physical activity has beneficial effects on several mental health outcomes In addition ... there is a strong belief that regular participation in physical activity is linked to enhancement of brain function and cognition, thereby positively influencing academic performance."

Several mechanisms that help explain why physical activity benefits cognition have been proposed. For starters, exercise increases blood and oxygen flow to your brain, which in and of itself increases learning speed.2 Exercise also increases levels of norepinephrine and endorphins, which lowers stress and improves mood. Importantly, exercise triggers growth factors that create new nerve cells and enable brain plasticity, thereby facilitating memory and learning. According to the authors of this 2012 review:

"The increasing pressures to improve academic scores often lead to additional instructional time for subjects such as mathematics and language at the cost of time for being physically active [T]he literature provides inconclusive evidence on the positive longitudinal relationship between physical activity and academic performance. However, there is a strong general belief that this relationship is present, and research in this area is ongoing."

The Motivation Factor

The featured documentary, "The Motivation Factor,"3 investigates these claims, showing how exercise and particularly physical education (PE) in school helps motivate kids and young adults to excel in other areas of life, including academically.

"The knowledge that the physical well-being of the citizen is an important foundation for the vigor and vitality of all the activities of the nation, is as old as the Western civiliz...

Do Your Moles Ever Go Away? "IndyWatch Feed Health"

By Dr. Mercola

Skin is your body's largest and fastest growing organ, used to protect your body from bacteria and germs, regulate your temperature, get rid of waste products and house a nervous system that allows you to feel and sense your environment.1 Your skin is what others first notice about you, and is an indicator of both internal and external aging.

Skin cancer is one of the most common types of cancer in the U.S.2 Estimates suggest nearly 20 percent of all Americans will experience some form of skin cancer during their life. Non-melanoma skin cancers affect nearly 3 million Americans each year and more than 1 million are living with melanoma. The rates of diagnosis of basal cell (BCC) and squamous cell carcinomas (SCC), non-melanoma skin cancers, have been rising dramatically.

There has been an increase of 145 percent of BCC between 1976 to 1984 and 2000 to 2010, and a 263 percent increase of SCC during the same period.3 Routinely inspecting your skin increases the likelihood you'll recognize changes that may need medical attention, and will help you become more familiar with your unique pattern of moles (nevi), freckles and blemishes.

Monthly self-inspection is done in a well-lit room with the assistance of mirrors to inspect areas that are difficult to see. Your first examination may take longer as you record the location of moles and freckles on your body. This enables you to confirm the location and any changes each month forward. You might notice that a mole suddenly appears where there wasn't one before, or a mole you've had for years may start to disappear.

Evolution of a Mole

Moles are growths on your skin that are usually black or brown, but can be a lighter tan. They usually appear in childhood anywhere on your body, either alone or in groups. By the time you reach your mid-20s it's common to have 10 to 40 moles.4 Moles happen when cells that provide color to your skin melanocytes grow in clumps together instead of spreading throughout your skin. After being exposed to the sun or during hormonal changes, such as your teen years or pregnancy, moles may darken in color.

Not all moles are created equally. The common mole is 5 to 6 mm in diameter...


Plantago asiatica seed extract improves lipid accumulation and hyperglycemia in high-fat diet-induced obese mice. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2017 Jun 30 ;18(7). Epub 2017 Jun 30. PMID: 28665305 Abstract Title:  Plantago asiatica L. Seed Extract Improves Lipid Accumulation and Hyperglycemia in High-Fat Diet-Induced Obese Mice. Abstract:  Obesity and its common association with type 2 diabetes, dyslipidemia, and cardiovascular diseases are worldwide epidemics. Currently, to prevent or treat obesity and associated metabolic disorders, herbal dietary supplements or medicines have attracted more and more attention owing to their relative effectiveness with fewer significant side effects. We investigate the therapeutic effects and underlying mechanisms ofL. seed extract (PSE) on obesity and associated metabolic disorders in high-fat (HF) diet-induced mice. Our results displayed that PSE did not modify food intake or body weight but decreased abdominal white adipose tissue ratio, white/brown adipocyte size, serum total cholesterol, triglyceride (TG), low density lipoprotein cholesterol, free fatty acid, and hepatic TG concentrations when compared with the HF group. The levels of fasting blood glucose and glucose tolerance were improved in the PSE group when compared with the HF group. Furthermore, PSE upregulated mRNA expressions of peroxisome proliferator activated receptors (PPARs) and target genes related to fatty acid metabolism and energy expenditure in liver and adipose tissue of obese mice when compared with the HF group. PSE treatment effectively improved lipid and glucose metabolism in HF diet-induced obese mice. These effects might be attributed to the upregulation of PPAR signaling.

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Molecular properties and immunomodulatory activities of a water-soluble heteropolysaccharide isolated from Plantago asiatica. "IndyWatch Feed Health"

PMID:  Nat Prod Res. 2018 Jan 31:1-4. Epub 2018 Jan 31. PMID: 29385853 Abstract Title:  Molecular properties and immunomodulatory activities of a water-soluble heteropolysaccharide isolated from Plantago asiatica L. leaves. Abstract:  This study aims at investigating physical-chemical properties of a water-soluble heteropolysaccharide from Plnatago asiatica L. leaves, and its immunomodulatory effects on macrophages RAW264.7 cells. Hot water-extracted crude polysaccharide from the plant leaves (PLLCP) was fractionated into four fractions by DEAE Sepharose Fast Flow eluted with 0.1-0.5 M NaCl solutions. The most abundant fraction (0.3 M NaCl elution), designated PLLP-2, was identified as a heteropolysaccharide with an average molecular weight (M) of 3.54  10and composed mainly of Gal (34.4%), GalA (36.5%), Ara (10.1%) and Rha (8.4%). PLLP-2 was an acidic polysaccharide exhibiting inflaky curly aggregation with smooth surface. PLLCP and its main subfraction PLLP-2 displayed immunomodulatory activities by stimulating the production of pro-inflammatory cytokines, including TNF- and IL-1 in macrophage RAW264.7 cells. These results indicate that the main polysaccharide fraction purified from P. asiatica L. leaves is probably pectin, and have potential immunomodulatory function.

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A. vera extract exhibited pancreatic islet cell rejuvenation. "IndyWatch Feed Health"

PMID:  Pharmacognosy Res. 2017 Dec ;9(Suppl 1):S99-S104. PMID: 29333050 Abstract Title:  Improvement of Insulin Secretion and Pancreatic-cell Function in Streptozotocin-induced Diabetic Rats Treated withExtract. Abstract:  Background: Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia. Plant extracts and their products are being used as an alternative system of medicine for the treatment of diabetes.has been traditionally used to treat several diseases and it exhibits antioxidant, anti-inflammatory, and wound-healing effects. Streptozotocin (STZ)-induced Wistar diabetic rats were used in this study to understand the potential protective effect ofextract on the pancreatic islets.Objective: The aim of the present study was to evaluate theextract on improvement of insulin secretion and pancreatic-cell function by morphometric analysis of pancreatic islets in STZ-induced diabetic Wistar rats.Materials and Methods: After acclimatization, male Wistar rats, maintained as per the Committee for the Purpose of Control and Supervision of Experiments on Animals guidelines, were randomly divided into four groups of six rats each. Fasting plasma glucose and insulin levels were assessed. The effect ofextract in STZ-induced diabetic rats on the pancreatic islets by morphometric analysis was evaluated.Results: Oral administration ofextract (300 mg/kg) daily to diabetic rats for 3 weeks showed restoration of blood glucose levels to normal levels with a concomitant increase in insulin levels upon feeding withextract in STZ-induced diabetic rats. Morphometric analysis of pancreatic sections revealed quantitative and qualitative gain in terms of number, diameter, volume, and area of the pancreatic islets of diabetic rats treated withextract when compared to the untreated diabetic rats.Conclusion: extract exerts antidiabetic effects by improving insulin secretion and pancreatic-cell function by restoring pancreatic islet mass in STZ-induced diabetic Wistar rats.SUMMARY: Fasting plasma glucose (FPG) and insulin levels were restored to normal levels in diabetic rats treated withextractIslets of pancreas were qualitatively and quantitatively restored to normalcy leading to restoration of FPG and insulin levels of diabetic rats treated withextractMorphometric analysis of pancreatic sections revealed quantitative and qualitative gain in terms of number, diameter, volume, and area of the pancreatic islets of diabetic rats treated withextract when compared to the untreated diabetic rats., FPG: Fasting plasma glucose, STZ: Streptozotocin, BW: Body weight.

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The results of this study support the existing data and the empirical uses of P. major. "IndyWatch Feed Health"

PMID:  Pharmacogn Mag. 2017 Jul-Sep;13(51):393-399. Epub 2017 Jul 19. PMID: 28839362 Abstract Title:  Effects ofExtracts and Its Chemical Compounds on Proliferation of Cancer Cells and Cytokines Production of Lipopolysaccharide-activated THP-1 Macrophages. Abstract:  BACKGROUND: has been reported to have anticancer and anti-inflammatory properties. However, its antiproliferative and anti-inflammatory mechanisms have not been fully elucidated. Moreover, which plant parts are more suitable as starting materials has not been explored.OBJECTIVES: To investigate the antiproliferative activity ofextracts against MCF-7, MDA-MB-231, HeLaS3, A549, and KB cancer cell lines as well as their effects on inflammatory cytokines (tumor necrosis factor [TNF]-, interleukin [IL]-1, IL-6, and interferon [IFN]-) production by lipopolysaccharide (LPS)-stimulated THP-1 macrophages.MATERIALS AND METHODS: The methanol and aqueous extracts offrom different plant parts and its chemical compounds, i.e., ursolic acid (UA), oleanolic acid (OA), and aucubin were tested in this experiment.RESULTS: Methanol and aqueous extracts ofseeds exhibited the greatest antiproliferative activity. The methanol extracts of seeds also demonstrated the highest inhibition of TNF-, IL-1, IL-6, and IFN- production. Interestingly, the roots, which were commonly discarded, exhibited comparable activities to those of leaves and petioles. Furthermore, UA exhibited stronger activities than OA and aucubin.CONCLUSIONS: The seeds are being proposed as the main source for further development of anticancer and anti-inflammatory products, whereas the roots could be included in the preparation ofderived products with respect to anti-inflammatory.SUMMARY: Amongst the parts of, seeds exhibited the greatest antiproliferative activity against MCF-7, MDA-MB-231, HeLaS3, A549, and KB cell lines as well as the highest inhibition on TNF-, IL-1, IL-6, and IFN- productionThe roots, which were commonly discarded, exhibited comparable antiproliferative and cytokines inhibition activities to those of leaves and petiolesUrsolic acid, a chemical compound of, exhibited stronger activities than oleanolic acid and aucubinThe seeds are being proposed as the main source for further development of anticancer and anti inflammatory products, whereas the roots could be included in the preparation ofderived products with respect to anti inflammatory.TNF: Tumor Necrosis Factor; IL: Interleukin; IFN: Interferon; HPTLC: High Performance Thin Layer Chromatography; UA: Ursolic Acid; OA: Oleanolic Acid; AUC: Aucubin.

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Chemical constituents and medical benefits of Plantago major. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2017 Dec ;96:348-360. Epub 2017 Oct 10. PMID: 29028587 Abstract Title:  Chemical constituents and medical benefits of Plantago major. Abstract:  The medicinal benefits of Plantago major have been acknowledged around the world for hundreds of years. This plant contains a number of effective chemical constituents including flavonoids, alkaloids, terpenoids, phenolic acid derivatives, iridoid glycosides, fatty acids, polysaccharides and vitamins which contribute to its exerting specific therapeutic effects. Correspondingly, studies have found that Plantago major is effective as a wound healer, as well as an antiulcerative, antidiabetic, antidiarrhoeal, anti-inflammatory, antinociceptive, antibacterial, and antiviral agent. It also combats fatigue and cancer, is an antioxidant and a free radical scavenger. This paper provides a review of the medicinal benefits and chemical constituents of Plantago major published in journals from year 1937 to 2015 which are available from PubMed, ScienceDirect and Google Scholar.

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Topical Plantavera gel seems to be an effective, cheap and safe treatment of diabetic foot ulcer. "IndyWatch Feed Health"

PMID:  Curr Drug Discov Technol. 2018 01 14. Epub 2018 Jan 14. PMID: 29336265 Abstract Title:  Efficacy of Aloe vera/ Plantago major gel in Diabetic Foot Ulcer: a randomized double-blind clinical trial. Abstract:  BACKGROUND: Diabetic foot ulcer (DFU) is one of the most common complications of diabetic patients. Mostly, non-healing DFU leads to infection, gangrene, amputation and even death. High costs and poor healing of the wounds need a new treatment such as alternative medicine. So, the aim of this study was to evaluate the efficacy of Aloe vera/ Plantago major gel (Plantavera gel) in healing of DFU.METHODS: Forty patients with DFU enrolled in a double-blind randomized clinical trial. The patients who were randomly assigned into the intervention group (n=20), received topical Plantavera gel in addition to the routine cares, whereas the patients in the control group (n=20), received topical Placebo gel in addition to the routine cares. Intervention was done twice a day for 4 weeks in the both groups. Photography and an evaluation of DFUhealing were conducted by a checklist and then were scored at baseline and at the end of each week. The collected data was analyzed by SPSS software.RESULTS: At the end of the study, there was a significant difference between the two groups in terms of total ulcer score (P

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Thymol can be therapeutic against high risk factors for Alzheimer's disease. "IndyWatch Feed Health"

PMID:  Brain Res Bull. 2018 Jan 13 ;137:338-350. Epub 2018 Jan 13. PMID: 29339105 Abstract Title:  Effects of thymol on amyloid--induced impairments in hippocampal synaptic plasticity in rats fed a high-fat diet. Abstract:  Obesity and a high-fat diet (HFD) are known to increase the incidence of Alzheimer's disease (AD). Oxidative stress, a major risk factor for AD, is increased with HFD consumption. Thymol (Thy) has antioxidant properties. Therefore, in the present study, we examined the protective and therapeutic effects of Thy on amyloid- (A)-induced impairments in the hippocampal synaptic plasticity of HFD-fed rats. In this study, 72 adult male Wistar rats were randomly assigned to 9 groups (n=8 rats/group): Group 1 (control; standard diet); Group 2: Control+phosphate-buffered saline (PBS)+Oil (Thy vehicle); Group 3 (HFD+PBS); Group 4: (HFD+A); Group 5: Control+PBS+Thy; Group 6: (HFD+A+Oil); Group 7: Control+A+Thy; Group 8: HFD+PBS+Thy; Group 9: (HFD+A+Thy). After stereotaxic surgery, the field potentials were recorded afterthe implantation of the recording and stimulating electrodes in the dentate gyrus (DG) and perforant pathway, respectively. Following high-frequency stimulation, the long-term potentiation (LTP) of the population spike (PS) amplitude and the slope of the excitatory postsynaptic potentials (EPSPs) were measured in the DG. The HFD rats that received A exhibited a significant decrease in their EPSP slope and PS amplitude as compared to the control group. In contrast, Thy administration in the HFD+A rats reduced the decrease in the EPSP slope and PS amplitude. Thy decreased the A-induced LTP impairments in HFD rats. The HFD significantly increased serum malondialdehyde levels and decreased total antioxidant capacity and total glutathione levels; whereas, Thy supplementation significantly reversed these parameters. Therefore, these results suggest that Thy, a natural antioxidant,can be therapeutic against high risk factors for AD, such as HFD.

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Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats. "IndyWatch Feed Health"

PMID:  Arq Neuropsiquiatr. 2018 Jan ;76(1):32-40. PMID: 29364392 Abstract Title:  Thymoquinone reverses learning and memory impairments and brain tissue oxidative damage in hypothyroid juvenile rats. Abstract:  In this study, the effect of thymoquinone (TQ) on propylthiouracil (PTU)-induced memory impairment was investigated in juvenile rats. The rats were grouped into control, Hypo, Hypo-TQ5 and Hypo-TQ10. Propylthiouracil increased latency time in the Morris water maze test and decreased delay in entering the dark compartment in the passive avoidance test. Both 5 mg/kg and 10 mg/kg doses of TQ decreased latency time in the Morris water maze test and increased delay in entering the dark compartment in a passive avoidance test. The PTU also increased malondialdehyde and nitric oxide metabolites in the brain while reduced the thiol content and superoxide dismutase and catalase activities and serum T4 level. Both doses of TQ decreased malondialdehyde and nitric oxide metabolites in the brain while enhanced the thiol content and superoxide dismutase and catalase activities and serum T4 level. The results of the present study showed that TQ protected against PTU-induced memory impairments in rats.

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Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2018 Jan 20 ;99:391-401. Epub 2018 Jan 20. PMID: 29367108 Abstract Title:  Thymoquinone activates MAPK pathway in hippocampus of streptozotocin-treated rat model. Abstract:  Streptozotocin (STZ), a glucosamine-nitrosourea compound, produces deficiencies in learning, memory, and cognitive functions when it was administered intracerebroventricularly (i.c.v). In molecular level, increase in neuroinflammation and oxidative stress in brain, and decrease in the number of surviving neurons are the outcomes of STZ administration. Herein, we aimed to investigate the effect of thymoquinone (TQ), an anti-inflammatory, immunomodulatory and neuroprotective agent, on STZ-induced neurodegeneration in rats. For this purpose, bilateral i.c.v. injection of STZ (3mg/kg) was given to adult female rats on days 1 and 3. TQ (20mg/kg/day in cornoil) was administered intragastrically to rats for 15 days starting from the 15th day of STZ injection. The Morris water maze test and passive avoidance test were applied to measure the learning and memory performance of animals. Following the behavioral tests, all of the rats were sacrificed for evaluation of molecular alterations. Rats in the STZ-TQ group showed higher performance in passive avoidance test than rats in the STZ group whose memory performance declined compared to control group. The worse memoryperformance in STZ group was correlated with low number of surviving neurons and high number of degenerating neurons. In addition, an increase in APOE expression and a decrease in NGF expression were observed with STZ injection. Administration of TQ reversed these STZ-triggered cognitive and molecular alterations. In the present study, we observed the neuroregenerative effects of TQ by activation of JNK protein, upregulation of mir-124, and downregulation of ERK1/2 and NOS enzymes. The same ameliorative effect of TQ was also observed in the pTau protein expression. To sum up, we can say thatthe healing effect of TQ on STZ induced neurodegeneration opens a new door for the development of Alzheimer's disease treatment using natural products as an adjuvant when their action mechanism was explained in detail.

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Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation. "IndyWatch Feed Health"

PMID:  Hum Exp Toxicol. 2018 Jan 1:960327118755256. Epub 2018 Jan 1. PMID: 29405769 Abstract Title:  Thymoquinone alleviates the experimentally induced Alzheimer's disease inflammation by modulation of TLRs signaling. Abstract:  Alzheimer's disease (AD) is characterized by a robust inflammatory response elicited by the accumulation and deposition of amyloid- (A) within the brain. A induces detrimental inflammatory responses through toll-like receptors (TLRs) signaling pathway. Thymoquinone (TQ), the main active constituent of Nigella sativa oil, has been reported by several previous studies for its potent anti-inflammatory effect. The aim of thisstudy is to elucidate the effect of TQ in improving learning and memory, using a rat model of AD induced by a combination of aluminum chloride (AlCl) and d-galactose (d-Gal). TQ was administered orally at doses of 10, 20, and 40 mg/kg/day for 14 days after AD induction. Memory functions were assessed using the step through passive avoidance test. Amyloid plaques were shown to be present using hematoxylin and eosin staining. Tumor necrosis factor-alpha (TNF-) and Interleukin-1beta (IL-1) levels in brain were assessed via ELISA and profiling TLR-2, TLR-4, myeloid differential factor 88, toll-interleukin-1 receptor domain-containing adapter-inducing interferon-, interferon regulatory factor 3 (IRF-3), and nuclear factor-B (NF-B) expressions viareal-time polymerase chain reaction. TQ improved AD rat cognitive decline, decreased A formation and accumulation, significantly decreased TNF- and IL-1 at all levels of doses and significantly downregulated the expression of TLRs pathway components as well as their downstream effectors NF-B and IRF-3 mRNAs at all levels of doses ( p

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Immunomodulatory and anti-inflammatory effects of thymoquinone. "IndyWatch Feed Health"

PMID:  Cardiovasc Hematol Disord Drug Targets. 2018 Feb 11. Epub 2018 Feb 11. PMID: 29437018 Abstract Title:  Immunomodulatory and Anti-inflammatory Effects of Thymoquinone. Abstract:  The immunomodulatory properties of Nigella sativa seed, as a basis of its clinical applications by many cultures have been reviewed. Thymoquinone (TQ) is one of the major bioactive component of the volatile oil of N. sativa seeds. The present investigations provide a comprehensive review of the ability of TQ to modulate inflammation and immune-related disorders in the various important disease states. This finding showed that TQ has the anti-inflammatory properties that prevents the biosynthesis of important mediators in inflammatory processes and asthma such as 5-LO, COX, PGD2 and LTs. TQ also reduced LPS-induced proinflammatory cytokines such as interleukins (ILs) and TNF-.. In addition, TQ showed the immunomodulatory role in the cellular and humoral immunity. This study also found that TQ improves the imidacloprid toxicity through reducing oxidative stress and increasing chemokinesis, chemotaxis, phagocytic activity, antibody levels and the hemagglutination of immunoglobulins as well as by reducing serum MDA levels and hepatic enzymes.

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antioxidant effect of thymoquinone could protect damage of liver parameters against morphine toxicity. "IndyWatch Feed Health"

PMID:  Int J Prev Med. 2018 ;9:8. Epub 2018 Jan 29. PMID: 29441185 Abstract Title:  The Effects of Thymoquinone Against Morphine-induced Damages on Male Mice Liver. Abstract:  Background: Morphine is a pain medication. It is mostly processed in liver and reasons disturbing effects. It can increase the production of free radicals. Thymoquinone is a phytochemical compound found in the plant. It has diverse pharmacological properties such as antioxidant and anticancer. This study was intended to assess the effects of thymoquinone against morphine damages on the liver of mice.Methods: In this study, various doses of thymoquinone (4.5, 9, and 18 mg/kg) and thymoquinone plus morphine was administered (once a day) intraperitoneally to 48 male mice for 20 consequent days. These mice were randomly assigned to eight groups (= 6). Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, serum nitric oxide (NO) levels, liver weight, and histology have been studied.Results: The results indicated that morphine administration significantly increased the mean diameter of central hepatic vein and hepatocyte, blood serum NO level, liver enzymes level, and decreased liver weight compared to saline group (

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Xanthohumol protects morphology and function in a mouse model of retinal degeneration. "IndyWatch Feed Health"

PMID:  Invest Ophthalmol Vis Sci. 2018 Jan 1 ;59(1):45-53. PMID: 29305606 Abstract Title:  Xanthohumol Protects Morphology and Function in a Mouse Model of Retinal Degeneration. Abstract:  Purpose: To investigate whether treatment with xanthohumol (XN), the principal prenylated chalconoid from Humulus lupulus (hops), is protective in a mouse model of light-induced retinal degeneration (LIRD).Methods: Mice (129S2/SvPasCrl) were intraperitoneally injected with vehicle or XN prior to toxic light exposure and every 3 days thereafter. Retinal function was assessed by electroretinograms at 1, 2, and 4 weeks following toxic light exposure. Visual acuity was tested by optokinetic tracking 1 week and 4 weeks after toxic light exposure. Retina sections were stained with hematoxylin and eosin for morphologic analysis or by TUNEL. Redox potentials were assessed in retinal tissue by measuring levels of cysteine (CYS), cystine (CYSS), glutathione (GSH), and glutathione disulfide (GSSG) using HPLC with fluorescence detection.Results: Toxic light significantly suppressed retinal function and visual acuity, severely disrupted the photoreceptor cell layer, and significantly decreased the number of nuclei and increased the accumulation of TUNEL-labeled cells in the outer nuclear layer. These effects were prevented by XN treatment. Treatment with XN also maintained GSSG and CYSS redox potentials and the total CYS pool in retinas of mice undergoing toxic light exposure.Conclusions: XN treatment partially preserved visual acuity and retinal function in the LIRD mouse. Preservation of retinal CYS and of GSSG and CYSS redox potentials may indicate that XN treatment induces an increased antioxidant response, but further experiments are needed to verify this potential mechanism. To our knowledge, this is the first study to report protective effects of XN in a model of retinal degeneration.

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Antibiofilm activity of bioactive hop compounds toward susceptible and resistant staphylococci. "IndyWatch Feed Health"

PMID:  Res Microbiol. 2018 Jan 30. Epub 2018 Jan 30. PMID: 29407045 Abstract Title:  Antibiofilm activity of bioactive hop compounds humulone, lupulone and xanthohumol toward susceptible and resistant staphylococci. Abstract:  Bacterial biofilms pose a serious medical problem due to their significant resistance to antimicrobials, and staphylococci are recognized as the most frequent cause of biofilm-associated infections. The hop plant (Humulus lupulus L.) contains substances that have been determined to act as anti-infective agents against bacteria, mainly in planktonic form. Therefore, we decided to investigate the antibiofilm properties of Humulus lupulus L.-derived compounds (humulone, lupulone and xanthohumol) against a selected group of Staphylococcus spp., including methicillin-susceptible and resistant strains. All tested hop compounds were shown to possess antimicrobial properties against all tested staphylococci, both planktonic and biofilm-dwelling, with no significant difference between resistant and susceptible strains. All compounds lowered the number of bacterial cells released from the biofilm, with the strongest effect seen for lupulone, followed by xanthohumol. Moreover, lupulone and xanthohumol were not only able to penetrate the biofilm and reduce the number of bacteria within it, but their higher concentrations (60 g/mL for xanthohumol and 125 g/mL for lupulone) reduced the number of surviving bacterial cells to zero.

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Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. "IndyWatch Feed Health"

PMID:  Asia Pac J Clin Nutr. 2018 ;27(2):341-346. PMID: 29384321 Abstract Title:  Astaxanthin improves glucose metabolism and reduces blood pressure in patients with type 2 diabetes mellitus. Abstract:  BACKGROUND AND OBJECTIVES: This randomized, placebo-controlled trial was performed for 8 weeks to investigate the potential effects of astaxanthin (AST) supplementation on the adiponectin concentration, lipid peroxidation, glycemic control, insulin sensitivity, and anthropometric indices in participants with type 2 diabetes mellitus.METHODS AND STUDY DESIGN: We enrolled 44 participants with type 2 diabetes who met our inclusion criteria. Eight milligrams of AST supplementation or a placebo were randomly administered once daily for 8 weeks to these participants.RESULTS: The 8-week administration of AST supplementation increased the serum adiponectin concentration and reduced visceral body fat mass (p

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Xanthohumol prevents dextran sulfate sodium-induced colitis. "IndyWatch Feed Health"

PMID:  Oncotarget. 2018 Jan 2 ;9(1):866-880. Epub 2017 Dec 12. PMID: 29416662 Abstract Title:  Xanthohumol prevents dextran sulfate sodium-induced colitis via inhibition of IKK/NF-B signaling in mice. Abstract:  Xanthohumol (XN), a prenylated chalcone isolated from the hop plant, has been reported to exhibit multiple biological functions including anti-inflammation. However, the pharmacological function of XN on colitis remains unknown. In this study, we investigated the anti-inflammatory effect of synthesized XN and molecular mechanism on dextran sulfate sodium (DSS)-induced experimental colitis. XN attenuated the colitis symptoms along with the prevention of colonic lesions after DSS challenge. XN inhibited the production of pro-inflammatory cytokines, oxidative stress and cyclooxygenase-2 expression in DSS-treated mice. Moreover, XN inhibited the phosphorylation of IB, the nuclear translocation of NF-B subunits and the transcriptional activity of NF-Band. In contrast to XN, isoXN showed much less effects on the kinase activity of IKK and IB phosphorylation induced by XN in this study, suggesting that an electrophilic carbon center present in XN is critical for the anti-inflammation in colitis, especially inhibition of IKK/NF-B signaling pathway. Consistently, our docking analysis revealed that XN could bind to the active site, presumably at the Cys99 of IKK. Taken together, these findings demonstrate a new function of XN to inhibit IKK/NF-B signaling, suggesting XN could be the potential therapeutic agent for the prevention of colitis.

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Xanthohumol may potentially be useful as a chemopreventive agent during breast hyperplasia and carcinogenesis. "IndyWatch Feed Health"

PMID:  Oncol Lett. 2018 Jan ;15(1):908-916. Epub 2017 Nov 17. PMID: 29422966 Abstract Title:  Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathwayand. Abstract:  Natural compounds derived from plants have been an important source of numerous clinically useful anticancer agents. Nevertheless, limited studies indicate that xanthohumol (XN), a major prenylated flavonoid in hop plants (Humulus lupulus), may possess anticarcinogenic properties. The purpose of the present study was to clarify the antitumorigenic effects and the underlying mechanism of XN on breast cancerand. A 4T1 breast tumor mouse model was used in the present study to investigate XN suppression of tumor growth as detected by tumorigenicity assays. In addition,studies revealed that XN significantly decreased cell viability, induced G/Gcell cycle arrest and apoptosis in MCF-7 and MDA-MB-231 cells, as confirmed by an MTT assay, flow cytometry and western blot analysis, indicating anticarcinogenic activity of XN against breast cancer. Furthermore, immunohistochemistry was performed to confirm the inactivation of the Notch signaling pathway, Notch 1 and Ki-67,; consistently, XN caused decreased activation of the Notch signaling pathway and apoptotic regulators B-cell lymphoma-2 (Bcl-2), Bcl-extra large and caspase 3, as determined by western blot analysis. This study suggests that XN may potentially be useful as a chemopreventive agent during breast hyperplasia and carcinogenesis, acting via the regulation of Notch associated apoptotic regulatorsand.

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These results suggest that a synergistic effect between luteolin and LED could be a new effective therapy in relieving neuroinflammation. "IndyWatch Feed Health"

PMID:  Am J Transl Res. 2018 ;10(1):283-291. Epub 2018 Jan 15. PMID: 29423013 Abstract Title:  LED enhances anti-inflammatory effect of. Abstract:  Neuroinflammation is a complex pathological process usually results from abnormal microglial activation, thus, intervention in a microglial stimulation pathway could be a promising approach for the treatment of neurodegenerative diseases. Luteolin is an important bioflavonoid possesses anti-inflammatory properties, which is widely studied over these years. Light emitting diode (LED) therapy is reported to be a potential therapeutic strategy for many diseases including neurodegenerative diseases. However, little is known about the anti-inflammatory effect of LED therapy on activated microglial cells, even less is known whether there is a synergistic anti-inflammatory effect exist in LED and luteolin therapy. In this study, we aimed to confirm the anti-inflammatory effect of luteolin and LED combination therapy in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. We showed that luteolin inhibited LPS-induced cytotoxicity, tumor necrosis factor alpha (TNF) and interleukin-6 (IL-6) production through modulation of p38 and extracellular signal-regulated kinase (ERK) signaling in BV2 cells. In addition, LED therapy enhanced the anti-inflammatory effect of luteolin. These results suggest that a synergistic effect between luteolin and LED could be a new effective therapy in relieving neuroinflammation.

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Sulfuryl Fluoride: Car dealers versus the stink bug "IndyWatch Feed Health"

Note from FAN: Sulfuryl Fluoride is a highly neurotoxic fumigant (see health effects). The molecular formula is:

Tauranga MP and National Party leadership prospect Simon Bridges has been called on to tackle the nasty brown marmorated stink bug.

The bug has spread to the United States and Europe from Asia. Theyre hard to see, hard to kill, travel far and breed fast.

The Ministry of Primary Industries considers them to be a damaging economic pest and a significant household nuisance.

Now the stink bug is threatening to bring the New Zealand used Japanese car trade to its knees. Jono Allen of Tauranga Cars says compliance shops are empty with staff standing around and panel and paint shops, vehicle groomers, car stereo installers are all similarly affected.

This affects hundreds if not thousands of businesses nationwide and is costing the country huge amounts of lost revenue every day.

After the discovery of the brown marmorated stink bug, four ships carrying used cars from Japanese have been turned away from Ports of Auckland.

These boats have several thousand Japanese used vehicles on-board destined for New Zealand marketplace. They are currently in limbo as Australia has refused them to berth to have Fumigation with Sulfuryl Fluoride performed. Because of this the industry is grinding to a stand-still.

And Jono Allen has told Simon Bridges that the industry needs his help.

We need immediate action from the Minister of Primary Industries to allow Sulfuryl Fluoride to be used in New Zealand ports to treat these boats, says Jono.

There are many other vessels on their way from Japan and they will probably be affected too.

He has told Simon Bridges that every day that goes by means lost incomes, lost revenue and potentially lost jobs.

This is a serious national issue which requires your immediate attention. Please support our local motor industry.

The bug can be eliminated with heat treatment but thats not practicable with the volume of cars involved. Jono says the only other solution is to fumigate with Sulfuryl Fluoride....

Thursday, 15 February


Fluoride amendment bill to give power to DHBs "IndyWatch Feed Health"

The Health (Fluoridation of Drinking Water) Amendment Bill is currently at its second reading in parliament, but American Professor Paul Connett says fluoride damages the brain and hell present his findings to parliament this month.

The biggest concern today is the fluoride damages the brain, weve got over 300 animal studies and human studies and 51 out of 58 studies have found lowered IQ in villages with high fluoride compared with villages with low fluoride, says Connett.

Hes an emeritus professor at the Environmental Chemistry at St Lawrence University in Canton, New York. Hes here visiting different parts of the country spreading his anti-flouride message.

Connett will be presenting against the Health Flouridation Water Bill amendment which will allow DHBs to make decisions and give directions about the fluoridation of drinking water in their communities.

Ive been brought here from FAN (Flouride Action Network) to talk to communities which are not flouridated at the moment because there is a bill going through parliament which will essentially make flouridation mandatory so even though youve been able to keep flouridation out of Napier for years, you could find suddenly that youre forced to flouridate.

The Ministry of Health says there is strong international and New Zealand evidence from over 60 years that tell us that there are no health risks associated with community water fluoridations at the levels used in New Zealand.

Fluoride is present in major cities like Auckland, Wellington, Dunedin and in a few water supplies in smalltown New Zealand but  MOH say levels here comply with World Health Organisation standards.

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