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Friday, 23 March

01:10

Super Antioxidant Chaga Mushrooms: Healing Cancer and Autoimmune Diseases "IndyWatch Feed Health"

mushroom chaga on old fallen trees in the forest.

Chaga mushrooms on old fallen trees in a forest.

by Paul Fassa
Health Impact News

The information in this article is not intended to give medical advice. This information is for educational purposes, showing the options beyond chemo and radiation for cancer.

Mushrooms are among the least publicized potential cancer treatment adjuncts to alternative cancer treatments. Even most holistic medical practitioners and journalists ignore the immune boosting and moderating properties of medicinal mushrooms.

Do chaga mushrooms have anti-cancer properties that mainstream oncology is obliged to suppress in order to maintain its high revenue monopoly over cancer victims and their families? Some say chaga does well as both a healing agent for cancer or as an adjunct to help chemo patients survive their ordeal.

The Chaga Mushroom (Inonotus obliquus)

This mushroom provides a folk medicine that has been used for hundreds of years in northern climates, especially Russia. Science writer Ralph Moss, Ph.D., stated there are at least 135 PubMed chaga studies with 44 demonstrating efficacy on cancer, but unfortunately none were human trials.

Ralph Moss was fired from his media relations position with the Memorial Sloane-Kettering Cancer Institute after publicly leaking the lies that covered up their own scientists positive evidence of efficacy and safety with laetrile.

Ironically, Sloane-Kettering has acknowledged the validity of many lab culture (in vitro) and animal (in vivo) studies on chaga mushrooms and is suggesting human studies, unlikely events since theres no chance of cashing in on patents to motivate funding human trials.

Though not published in a medical journal or perhaps published and lost, Moss divulged what he had discovered from other reliable sources.

In a 48-patient human clinical trial in Poland in 1957, ten patients treated with chaga showed a reduction of tumor size, a decrease in pain, a...

00:59

Curcumin, resveratrol, and EGCG, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors. "IndyWatch Feed Health"

PMID:  Cancer Immunol Immunother. 2018 Feb 16. Epub 2018 Feb 16. PMID: 29453519 Abstract Title:  TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors. Abstract:  Our earlier studies reported a unique potentiated combination (TriCurin) of curcumin (C) with two other polyphenols. The TriCurin-associated C displays an IC50 in the low micromolar range for cultured HPV+TC-1 cells. In contrast, because of rapid degradation in vivo, the TriCurin-associated C reaches only low nano-molar concentrations in the plasma, which are sub-lethal to tumor cells. Yet, injected TriCurin causes a dramatic suppression of tumors in TC-1 cell-implanted mice (TC-1 mice) and xenografts of Head and Neck Squamous Cell Carcinoma (HNSCC) cells in nude/nude mice. Here, we use the TC-1 mice to test our hypothesis that a major part of the anti-tumor activity of TriCurin is evoked by innate and adaptive immune responses. TriCurin injection repolarized arginase1(ARG1), IL10, inducible nitric oxide synthase(iNOS), IL12M2-type tumor-associated macrophages (TAM) into ARG1, IL10, iNOS, and IL12M1-type TAM in HPV+tumors. The M1 TAM displayed sharply suppressed STAT3 and induced STAT1 and NF-kB(p65). STAT1 and NF-kB(p65) function synergistically to induce iNOS and IL12 transcription. Neutralizing IL12 signaling with an IL12 antibody abrogated TriCurin-induced intra-tumor entry of activated natural killer (NK) cells and Cytotoxic T lymphocytes (CTL), thereby confirming that IL12 triggers recruitment of NK cells and CTL. These activated NK cells and CTL join the M1 TAM to elicit apoptosis of the E6+tumor cells. Corroboratively, neutralizing IL12 signaling partially reversed this TriCurin-mediated apoptosis. Thus, injected TriCurin elicits an M2M1 switch in TAM, accompanied by IL12-dependent intra-tumor recruitment of NK cells and CTL and elimination of cancer cells.

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00:15

Mom Stands Up to Dental Bullying When Dentist Threatens to Call CPS Over Missed Dental Appointment "IndyWatch Feed Health"

Trey Hoyumpa

Pennsylvania mom Trey Hoyumpa is taking a stand against Dental Bullying. Image from Facebook.

by Terri LaPoint
Health Impact News

Is Medical Kidnapping now spreading to the dental profession?

Parents all over social media are in an uproar over a letter posted by a Pennsylvania mother from her childrens dentist office. Smiles4Keeps Pediatric Dentistry sent a letter to a mother threatening to call Child Protective Services if she did not schedule a dental appointment for her child.

The dental office staff has responded to the post and comments with a post of their own, defending their actions as being their legal obligation. Instead of quieting public fears, the response appears even more disturbing to parents, who are accusing the dental office of bullying, and blackmail.

Here is the letter posted on Facebook that Trey Hoyumpa allegedly received in the mail on March 19, 2018, from the Bartonsville, Pennsylvania, Smiles4Keeps office:

dentist letter threatens medical kidnapping

Trey Hoyumpa isnt smiling. Neither are the hundreds of other parents who have been sharing the post and commenting.

Parental Concerns over Office Policies

smiles4keeps

Image from...

00:10

Nigella sativa may be interesting adjuvant support in diabetes therapy and in treating dyslipidemia and coronary heart disease. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2017 ;2017:8427034. Epub 2017 Dec 12. PMID: 29479371 Abstract Title:  In Vivo Subacute Toxicity and Antidiabetic Effect of Aqueous Extract of. Abstract:  seeds are usually used as traditional medicine for a wide range of therapeutic purposes.To investigate the subacute toxicity of NS aqueous extract and select its lowest dose to study its antidiabetic effect.5 AqE.NS doses (2, 6.4, 21, 33, and 60g/Kg) were daily administered to mice by gavage. Biochemical parameters measurements and histological study of the liver and the kidney were performed after 6 weeks of supplementation. Thereafter, and after inducing diabetes by alloxan, rats were treated by 2g/Kg of AqE.NS during 8 weeks. Metabolic parameters were measured on sera. A horizontal electrophoresis of plasmatic lipoprotein was conducted. Glycogen, total lipids, and triglycerides were measured in the liver. TBARS were evaluated on adipose tissue, liver, and pancreas.AqE.NS showed no variation in urea and albumin at the 5 doses, but hepatotoxicity from 21g/Kg was confirmed by histopathological observations of the liver. In diabetic rats, AqE.NS significantly decreased glycemia, TG, T-cholesterol, LDL-c, and TBARS and showed a restored insulinemia and a significant increase in HDL-c. Results on the liver indicated a decrease in lipids and a possible glycogenogenesis.AqE.NS showed its safety at low doses and its evident antihyperglycemic, antihyperlipidemic, and antioxidant effect.

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Thursday, 22 March

23:47

Thymoquinone holds potential for neuroprotection and may be a promising approach for the treatment of neurodegenerative disorders. "IndyWatch Feed Health"

PMID:  Neurol Res. 2018 Apr ;40(4):324-333. Epub 2018 Feb 21. PMID: 29464986 Abstract Title:  Protective effects of thymoquinone on D-galactose and aluminum chloride induced neurotoxicity in rats: biochemical, histological and behavioral changes. Abstract:  OBJECTIVES: Thymoquinone (TQ), the main active ingredient in Nigella sativa oil, exhibits various bioactivities. This study aimed to investigate the effect of TQ on neurobehavioral and neuropathological alterations induced by aluminum trichloride (AlCl) and D-galactose (D-gal)-in male rats and to explore the related mechanisms.METHODS: D-gal (60 mg/kg day) and AlCl(10 mg/kg day) were given intraperitoneally (i.p.) once daily for 42 days and after 4 weeks TQ was concomitantly administered intragastrically (i.g.) (20 mg/kg/day) once daily for 14 days. Then, memory function was evaluated by Morris water maze test (MWM). Superoxide dismutase (SOD), Total antioxidant capacity (TAC), Acetylcholinesterase (AChE) activities, and malondialdehyde (MDA), nitric oxide (NO), brain-derived neurotrophic factor (BDNF), and B-cell lymphoma-2 (Bcl-2) levels in whole brain were assessed with the biochemical technique. Tumor necrosis factor-alpha (TNF-) and Acetylcholine (ACh) were also assessed using an immunohistochemical technique.RESULTS: Administration of TQ significantly improved cognition. In addition, TQ significantly increased SOD and TAC and decreased AChE activities. It also decreased MDA and NO levels as well as TNF- immunoreactivity and increased BDNF and Bcl-2 levels as well as ACh immunoreactivity.DISCUSSION: Our results indicate that TQ prevents D-gal/AlCl-induced cognitive decline by enhancing cholinergic function and synaptic plasticity as well as attenuation of oxidative damage, neuronal apoptosis, and neuroinflammation. These results indicate that TQ holds potential for neuroprotection and may be a promising approach for the treatment of neurodegenerative disorders.

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23:37

This review describes protective role and related mechanism of thymoquinone against liver injuries. "IndyWatch Feed Health"

PMID:  Recent Pat Food Nutr Agric. 2018 Feb 20. Epub 2018 Feb 20. PMID: 29473535 Abstract Title:  An overview on hepatoprotective effects of thymoquinone. Abstract:  Liver as an essential organ has an important function in metabolism and waste secretion from the body. Disorders of this organ may caused by several reasons such as high alcoholic consumption, various chemical or microbial agents and various hepatic cancers. Reactive and oxidative stress and oxygen species (ROS) are introduced the main mechanisms of these hepatic injuries. The seeds of Nigella sativa (Family Ranunculaceae) which is known as black seed, is widely used as a medicinal herb for cure or prevention of many of diseases such as liver problems. Thymoquinone (TQ) as a bioactive phytochemical constituent of Nigella sativa has hepatoprotective effects against of injures through different mechanisms including radical scavenging. This review describes protective role and related mechanism of TQ against liver injuries.

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23:21

In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa. "IndyWatch Feed Health"

PMID:  Turk J Med Sci. 2018 Feb 23 ;48(1):178-186. Epub 2018 Feb 23. PMID: 29479981 Abstract Title:  In vivo attenuation of angiogenesis in hepatocellular carcinoma by Nigella sativa Abstract:  Background/aim: Angiogenesis is imperative in malignant tumor growth. Hepatocellular carcinoma is a typical hypervascular tumor that relies on angiogenesis. The aim of this study is to investigate the in vivo molecular mechanism underlying the antitumor properties of Nigella sativa ethanolic extract (NSEE) through its antiangiogenic effect against diethyl nitrosamine (DENA)-induced hepatocarcinogenesis. Materials and methods: Male Wistar rats were divided into 4 groups: normal, NSEE, DENA, and NSEE-DENA groups. Final body weight, hepatosomatic indices, serum AFP, serum vascular endothelial growth factor (VEGF) levels, and liver tissue hepatocyte growth factor (HGF) protein expression were estimated. Liver sections were stained for histological examination. AFP levels with the histological variations were chosen to confirm cancer development. Results: DENA significantly increased liver weight, hepatosomatic indices, serum AFP and VEGF levels, and liver HGF protein expression and significantly decreased final body weight. These effects were significantly reversed by NSEE. Furthermore, the histopathological changes that appeared in rat livers due to DENA were reduced by NSEE without harmful effects when taken alone. Conclusion: The results of the present investigation provide evidence that the in vivo antiangiogenic effect of NSEE through downregulation of serum VEGF and liver HGF protein could be implicated in its antitumor activity. Its consumption has health benefits that favor liver cancer management. These findings might prove useful and helpful for the progression of therapies for hepatocarcinogenesis treatment.

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23:21

Mom Stands Up to Dental Bullying When Dentist Threatens to Call CPS Over Missed Dental Appointment "IndyWatch Feed Health"

Trey Hoyumpa

Pennsylvania mom Trey Hoyumpa is taking a stand against Dental Bullying. Image from Facebook.

by Terri LaPoint
Health Impact News

Is Medical Kidnapping now spreading to the dental profession?

Parents all over social media are in an uproar over a letter posted by a Pennsylvania mother from her childrens dentist office. Smiles4Keeps Pediatric Dentistry sent a letter to a mother threatening to call Child Protective Services if she did not schedule a dental appointment for her child.

The dental office staff has responded to the post and comments with a post of their own, defending their actions as being their legal obligation. Instead of quieting public fears, the response appears even more disturbing to parents, who are accusing the dental office of bullying, and blackmail.

Here is the letter posted on Facebook that Trey Hoyumpa allegedly received in the mail on March 19, 2018, from the Bartonsville, Pennsylvania, Smiles4Keeps office:

dentist letter threatens medical kidnapping

Trey Hoyumpa isnt smiling. Neither are the hundreds of other parents who have been sharing the post and commenting.

Parental Concerns over Office Policies

smiles4keeps

Image from...

22:11

Public Health England Makes a Scientific Ass of Itself "IndyWatch Feed Health"

Public Health England Makes a Scientific Ass of Itself

On March 22, Public Health England issued a report titled Water Fluoridation. Health monitoring report for England 2018 . It is yet another sham review by a pro-fluoridation government agency.

Public Health England described itself this way:

Public Health England exists to protect and improve the nations health and wellbeing, and reduce health inequalities. We do this through world-leading science, knowledge and intelligence, advocacy, partnerships and the delivery of specialist public health services. We are an executive agency of the Department of Health and Social Care, and a distinct delivery organisation with operational autonomy. We provide government, local government, the NHS, Parliament, industry and the public with evidence-based professional, scientific and delivery expertise and support. (page 2)

Public Health England on fluoride and IQ:

 At the time the PHE working group were considering health outcomes, the evidence for an association between lower IQ and fluoride in water was considered weak (22, 24), and there were no quality routine datasets available for analysis. Therefore IQ was not considered a priority health outcome for inclusion. (page 23)

Comment from FAN:

We recommend our readers re-read these two statements again while listening to a recording of Elgars famous Pomp and Circumstance march!

The two references used for this statement were from outdated rubber-stamp reports from Ireland (2015) and New Zealand (2014) (which we discussed in some detail in a previous bulletin.

It is a hallmark of these government sham reviews that they incestuously cite each other piling propaganda on top of propaganda but all the while trying to impress with their inflated authority.  Nowhere, was this clearer than with the NZ review which stressed that Sir Peter Gluckman was the senior scientific adviser to the Prime Minister of NZ and Sir David Skegg was the President of The Royal Society of New Zealand.  The shock comes when someone who knows the science of the issue actually reads their reports and finds how little they know about the subject.

Of course, neither the authors of these two sham reviews could have considered the Bashash et al., 2017 st...

21:43

More Doctors Are Prescribing Food as Medicine- Heres Why "IndyWatch Feed Health"

This article was written by Nicole Eckert, Holistic Nutritionist and the Owner + Founder of Holisticole. Check out her holistic living blog: holisticole.com for amazing clean-eating recipes, informative blog posts and online programs. Stay inspired by Nicoles passion follow her on Facebook & Instagram (@holisticole). BE vibrant. How do you feel on a day-to-day... View Article

The post More Doctors Are Prescribing Food as Medicine- Heres Why appeared first on Healthy Holistic Living.

21:33

As Pfizer CEO Gets Obscene Pay Raise, The Nations Health Declines "IndyWatch Feed Health"

Over the years, big pharma giant Pfizer Inc. has faced constant bombardment from all sides and for good reason. From addictive band-aid-type drugs to skyrocketing drug prices, Pfizer CEO Ian Read has come under fire for receiving a gluttonous pay raise. Bloomberg, in a 2017 financial filings report, revealed that Ian Read received $27,900,000 in... View Article

The post As Pfizer CEO Gets Obscene Pay Raise, The Nations Health Declines appeared first on Healthy Holistic Living.

21:28

Tinospora cordifolia induces cell cycle arrest in human oral squamous cell carcinoma cells. "IndyWatch Feed Health"

PMID:  Gulf J Oncolog. 2017 May ;1(24):10-14. PMID: 28797995 Abstract Title:  Tinospora Cordifolia Induces Cell Cycle Arrest in Human Oral Squamous Cell Carcinoma Cells. Abstract:  Natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. Tinospora cordifolia (Guduchi) has been used for centuries in Ayurvedic system of medicine for treating various ailments including cancer. In present study, we found that the Tinospora cordifolia extracts (TCE) induced inhibition of proliferation of KB cells was associated with arrest of G0/G1-phase of cell cycle. The effectiveness of TCE in checking the growth of KB cells without altering the growth of normal peripheral blood mononuclear cells (PBMC) indicates that Tinospora cordifolia has differential effect on normal and malignant cells hence, it may have therapeutic potential in cancer.

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21:04

New Study Says Motherhood is the Equivalent of Working 2.5 Full-Time Jobs "IndyWatch Feed Health"

Being a mom is one of the toughest, yet most rewarding jobs in the world and you dont even have to be a mother yourself to recognize that. Its a job that trains you to have plenty of skills such as organization, negotiation, communication, multi-tasking, managing people, and plenty more to add to the list.... View Article

The post New Study Says Motherhood is the Equivalent of Working 2.5 Full-Time Jobs appeared first on Healthy Holistic Living.

20:58

Leaked Report: Nahua Tribe Hit By Mercury Crisis Is Slowly Dying "IndyWatch Feed Health"

Did you know there are believed to be 15 uncontacted tribes still living in the Peruvian Amazon. Up until the mid-1980s, the indigenous Nahua people were included in that list. Since that time, contact with outsiders has seriously impacted their community. Now, a recent unpublished Health Ministry report is shedding light on a mercury poisoning... View Article

The post Leaked Report: Nahua Tribe Hit By Mercury Crisis Is Slowly Dying appeared first on Healthy Holistic Living.

20:47

Thymoquinone administration could have beneficial protective effects on sepsis. "IndyWatch Feed Health"

PMID:  Bratisl Lek Listy. 2018 ;119(3):152-155. PMID: 29536743 Abstract Title:  Investigation of the effects of thymoquinone on erythrocyte deformability in sepsis treatment which created by cecal perforation in rat. Abstract:  AIM: We aimed to study the effects of thymoquinone on erythrocyte deformability in an experimental model of sepsis given before or after the initiation of the sepsis model.METHOD: The animals were grouped as (n = 6) control, nigella sativa, sepsis, sepsis group with administration of nigella sativa before sepsis development and sepsis group with nigella sativa administration after sepsis development. Cecal ligation and puncture model (CLP) was used to induce sepsis in the animals. The thymoquinone was given 1 hour before or after the CLP in the study groups with a dose of 500 mgkg-1. Erythrocyte deformability and relative resistance was calculated.RESULT: Relative resistance was increased in the sepsis groups when compared to the control group (p

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20:37

Supplementation with N. sativa exerts a moderate effect on reduction in body weight, body mass index and waist circumference. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2018 Mar 17. Epub 2018 Mar 17. PMID: 29559374 Abstract Title:  The effects of Nigella sativa L. on obesity: A systematic review and meta-analysis. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Nigella sativa L. (N.sativa) is a traditional herbal medicine that has been used for centuries to treat rheumatoid arthritis, diabetes, asthma, and other metabolic disorders. Recently, anti-obesity characteristics of N.sativa have been indicated.AIM OF THE STUDY: The effects of N. sativa as a complementary therapy in obesity management remains controversial. We aimed to perform a meta-analysis on the effects of supplementation with N. sativa on some anthropometric indices in adult subjects.MATERIALS AND METHODS: We searched PubMed/Medline, Cochrane Library, ISI Web of Science, and Scopus databases untill June 2017 to identify relevant placebo-controlled clinical trials. Data was reported as weighted mean differences and standard deviations to show the magnitude of effects for N. sativa on body weight, body mass index (BMI) and waist circumference (WC).RESULTS: Findings of 11 studies revealed that N. sativa supplement reduced body weight (-2.11kg, 95% CI: -3.61, -0.61, I:72.4%), BMI (-1.16kg/m; 95%CI: -1.81, -0.51; I: 40.1%) and WC (-3.52cm, 95%CI: -4.10, -2.92, I=0%) significantly compared to placebo groups.CONCLUSION: Supplementation with N. sativa exerts a moderate effect on reduction in body weight, BMI and WC. However, due to the high heterogeneity for body weight and limited high quality studies, the findings should be declared by caution. No serious side effects were also reported following N. sativa supplementation. Further studies are needed to clarify the effects of N. sativa on other anthropometric indices.

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20:29

These Amino Acids and Antioxidants Could Treat Psychosis Soon "IndyWatch Feed Health"

 

By Heather CallaghanEditor

A new scientific systemic review offers rekindled hope in the ability of nutrients to ease the symptoms of schizophrenia.

The study aimed to determine which main amino acids and antioxidants could reduce typical symptoms of schizophrenia in addition to standard treatment. They were most interested in the effects of Taurine, NAC (n-acetyal-cysteine) and vitamins like C, B-complex and B9 on psychotic illness.

Also, this information applies to the early stages of onset, called First-episode psychosis (FEP). This is the first evaluation of its kind on nutritional supplements for this problem.

First, the authors first explain in Early Intervention in Psychiatry, that,

Firstepisode psychosis (FEP) refers to the first 2 to 5 years of a psychotic disorder, such as schizophrenia. The mainstay of treatment is antipsychotic medications, which reduce positive symptoms (eg, hallucinations and delusions) within weeks per month [1]. However, 80% of patients...

19:40

Role of gold and silver nanoparticles in cancer nano-medicine. "IndyWatch Feed Health"

PMID:  Artif Cells Nanomed Biotechnol. 2018 Mar 13:1-11. Epub 2018 Mar 13. PMID: 29533101 Abstract Title:  Role of gold and silver nanoparticles in cancer nano-medicine. Abstract:  Development of nanoparticles (NPs) as a part of cancer therapeutics has given rise to a new field of research - cancer nanomedicine. In comparison to traditional anti-cancer drugs, NPs provide a targeted approach which prevents undesirable effects. In this communication, we have reviewed the role of gold and silver NPs (AgNPs) in the cancer nanomedicine. The preparation of gold NPs (AuNPs) and AgNPs can be grouped into three categories - physical, chemical and biological. Among the three approaches, the biological approach is growing and receiving more attention due to its safe and effective production. In this review, we have discussed important methods for synthesis of gold and AgNPs followed by techniques employed in characterization of their physicochemical properties, such as UV-visible spectroscopy, electron microscopy (TEM and SEM) and size and surface analysis (DLS). The mechanism of formation of these NPs in an aqueous medium through various stages - reduction, nucleation and growth has also been reviewed briefly. Finally, we conclude our review with the application of these NPs as anti-cancer agents and numerous mechanisms by which they render cancer cell toxicity.

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19:31

Nano-gold displayed anti-inflammatory properties. "IndyWatch Feed Health"

PMID:  Artif Cells Nanomed Biotechnol. 2018 Mar 19:1-10. Epub 2018 Mar 19. PMID: 29553845 Abstract Title:  Nano-gold displayed anti-inflammatory property via NF-kB pathways by suppressing COX-2 activity. Abstract:  Rheumatoid arthritis (RA) is an autoimmune inflammatory disease, affecting almost 1% of world population. Although the exact cause of RA is not known but the complex interaction between inflammatory mediators like tumour necrosis factor- (TNF-), interleukin-1 (IL-1), cyclooxygenase-2 (COX-2) and nitric oxide (NO) is accountable for cartilage destruction in joints. Gold is used for arthritis treatment since long without knowing its mechanism of action. Hence, the present study was designed to assess antiarthritic activity ofnanogold (AuNGs) in collagen-induced arthritic (CIA) rat model by virtue of decreasing inflammatory mediators and oxidative stress. After induction CIA rats were treated with AuNGs in phosphate buffer at a dose of 20g/kg body weight for 20days and found a significant decrease in the level of inflammatory mediators like TNF-, IL-1, COX-2 and transcription factor NF-kB (Nuclear factor-kB), which was found to be elevated in CIA rats. Additionally imbalance in oxidant and antioxidant status were determined and perceived that AuNGs remarkably attenuates the imbalance in level of antioxidant and oxidant near to normal. In consistent to biochemical results, mRNA expression of NF-kB, TNF-, COX-2, and iNOS were also up-regulated in CIA rats, which were considerably down regulated by AuNGs treatment. These findings were positively correlated with the histological results of joints,displayed reduced inflammation and bone erosion in treated group. This study demonstrates the ability of AuNGs to ameliorate production of inflammatory mediators and oxidative stress in CIA rats. Induction of arthritis in rats showed increased inflammation, which activate the transcription factor NF-kB through activation of of IkB kinases (IKK) and ubiquination/proteosome degradation of IKB and transportation of activated NF-kB from cytoplasm to nucleus. In nucleus activated NF-kB bind to the promoter region of target gene and up regulate the production of pro-inflammatory cytokines, COX-2 andother inflammatory mediators that leads to cartilage destruction. AuNGs inhibit the activation of NF-kB and other inflammatory mediators and attenuate inflammation and cartilage destruction. COX-2: cyclooxygenase-2; IKK: IkB kinases; IKB: I Kappa B; IL-1: interleukin-6; IL-6: interleukin-6; iNOS:inducible nitric oxide synthase; NF-kB: nuclear transcription factor kappa B; ROS: reactive oxygen species; TNF-: tumour necrosis factor-alpha.

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19:14

Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy. "IndyWatch Feed Health"

PMID:  Biomaterials. 2018 Mar 14 ;167:80-90. Epub 2018 Mar 14. PMID: 29554483 Abstract Title:  Targeting epigenetic pathway with gold nanoparticles for acute myeloid leukemia therapy. Abstract:  Leukemia remains a fatal disease for most patients and novel therapeutic strategies are urgently needed. Aberrant DNA methylation is an epigenetic modification that is important in the initiation and progression of leukemia. Here, we demonstrated NCL/miR-221/NFB/DNMT1 axis as a new molecular pathway promoting aggressive acute myeloid leukemia (AML) leukemogenesis and successfully designed and prepared a nuclear localization signal (NLS) peptide-targeted gold nanoparticles with co-loaded anti-221 and AS1411 (NPsN-AS1411/a221), which can specifically target NCL/miR-221/NFB/DNMT1 signaling pathway in AML. NPsN-AS1411/a221 synergistically abrogate endogenous miR-221 promoting cancerous growth by inhibiting the expression of p27Kip1 suppressor gene, as well as effectively deregulate the DNMT1 expression through NFB signaling which led to a reduction of global DNA methylation and the restoration of tumor suppressor p15INK4B via its promoter DNA hypomethylation. Functionally, NPsN-AS1411/a221 remarkably blockage leukemia proliferation and clonogenic potential in NCL/miR-221/NFB/DNMT1 positive AML cell lines. More importantly, NPsN-AS1411/a221cooperatively extend the overall survival, lower the white blood cells, reverse splenomegaly, inhibit blasts in bone marrow and metastatic to lung in a preclinical AML animal model. Altogether, our studies provide a proof of concept for multiple-functional drug delivery system that based on the specific gene network involved in tumor growth, and highlight the clinical potential of NCL/miR-221/NFB/DNMT1-targeted AML nanotherapy.

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19:12

How to Go Green with Banana Flour "IndyWatch Feed Health"

banana flourIt seems there is an endless array of gluten free grains and paleo flours now flooding the market. This isnt a bad thing, but it can be bewildering for consumers. One that is really catching on comes from the most popular fruit in North America. Yes, thats right, banana flour!

Lets take at a look at this traditional food turned flour. 

The post How to Go Green with Banana Flour appeared first on The Healthy Home Economist.

18:54

The likelihood of disease increases from 4% to 89% when corals are in contact with plastic. "IndyWatch Feed Health"

PMID:  Science. 2018 01 26 ;359(6374):460-462. PMID: 29371469 Abstract Title:  Plastic waste associated with disease on coral reefs. Abstract:  Plastic waste can promote microbial colonization by pathogens implicated in outbreaks of disease in the ocean. We assessed the influence of plastic waste on disease risk in 124,000 reef-building corals from 159 reefs in the Asia-Pacific region. The likelihood of disease increases from 4% to 89% when corals are in contact with plastic. Structurally complex corals are eight times more likely to be affected by plastic, suggesting that microhabitats for reef-associated organisms and valuable fisheries will be disproportionately affected. Plastic levels on coral reefs correspond to estimates of terrestrial mismanaged plastic waste entering the ocean. We estimate that 11.1 billion plastic items are entangled on coral reefs across the Asia-Pacific and project this number to increase 40% by 2025. Plastic waste management is critical for reducing diseases that threaten ecosystem health and human livelihoods.

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18:35

This study estimates there are more than 5 trillion plastic pieces weighing over 250,000 tons afloat at sea. "IndyWatch Feed Health"

PMID:  PLoS One. 2014 ;9(12):e111913. Epub 2014 Dec 10. PMID: 25494041 Abstract Title:  Plastic Pollution in the World's Oceans: More than 5 Trillion Plastic Pieces Weighing over 250,000 Tons Afloat at Sea. Abstract:  Plastic pollution is ubiquitous throughout the marine environment, yet estimates of the global abundance and weight of floating plastics have lacked data, particularly from the Southern Hemisphere and remote regions. Here we report an estimate of the total number of plastic particles and their weight floating in the world's oceans from 24 expeditions (2007-2013) across all five sub-tropical gyres, costal Australia, Bay of Bengal and the Mediterranean Sea conducting surface net tows (N=680) and visual survey transects of large plastic debris (N=891). Using an oceanographic model of floating debris dispersal calibrated by our data, and correcting for wind-driven vertical mixing, we estimate a minimum of 5.25 trillion particles weighing 268,940 tons. When comparing between four size classes, two microplastic4.75 mm, a tremendous loss of microplastics is observed from the sea surface compared to expected rates of fragmentation, suggesting there are mechanisms at play that remove

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18:20

LSD Blurs Boundaries of Self and Others, Alleviates Depression "IndyWatch Feed Health"

LSD Blurs Boundaries of Self and Others, Alleviates Depression

By Brandon TurbevilleNatural Blaze

Yet another study has emerged demonstrating the benefit of LSD in treating various mental health issues.

LSD reduces the borders between the experience of ones own self and others. For that reason, it affects social interactions.

Researchers at University of Zurich have found that a serotonin receptor in the brain is crucially involved in the psychological mechanisms that involve experiencing both the self and others.

According to the researchers,

Virtually all mental health disorders come with difficulties in interpersonal relations that in the long run negatively affect the progression of the disease. The associated health and social restrictions can only be marginally improved by current forms of therapy. One of the reasons for this is that there has been very little research into the basic neurobiological principles and in particular the neurochemical mechanisms of these kinds of disorders. A further symptom of various psychiatric disorders is distortions of self-experience. People suffering from mental disorders often show either an inflated or weakened sense of self.

...

18:18

CDC Vaccine Science Covers Up Giant Conflict Of Interest "IndyWatch Feed Health"

By Jon Rappoport

If you wanted to buy a product

And the main researcher of the product was the company selling it to you

Would you automatically assume the product was safe and effective?

But you see, thats the just the beginning of the problem. Suppose the companys research was cited thousands of times in the press, as the authoritative standard of proofand anyone who disputed that research was labeled a conspiracy theorist and a quack and a danger to the community and an anti-science lunatic.

Would you begin to suspect the company had awesome media connections? Would you suspect some very powerful people were backing the company?

This is exactly the situation with the US Centers for Disease Control (CDC). Read these two quotes:

The governments Vaccine for Children Program (a CDC organization) purchases vaccines for about 50 percent of children in the U.S. (The Atlantic, February 10, 2015)

The CDC currently spends over $4 billion purchasing vaccines [annually] from drug makers (Health Impact News, October 24, 2016)

However, the CDC is also the gold standard for research on the safety and efficacy of vaccines. It turns out an unending stream of studies on these...

18:17

Only Crazy People Drink Raw Milk? The Wider Implications "IndyWatch Feed Health"

By Jon Rappoport

For a moment, dont think about whether raw milk is safe or dangerous, health-giving or harmful. Stop. There are wider implications here. And they affect every citizen.

Here is my article, from August 5, 2011. The issues are still quite relevant.

The federal raid on Rawesome Foods in Venice, California, is based on the insistence (with guns) that private citizens cant make contracts with each other to buy and sell raw unpasteurized milk.

Some uninformed types believe the raid was solely focused on the fact that Rawesome doesnt have a business license. But it is a private club, and the last time I looked, a club doesnt need a license to carry on its activities.

Do private citizens have the right to form an association, by contract, and then engage in exchange of goods and services, among its members, regardless of the opinion of the State?

18:11

The Amount of Plastic in Oceans Will Triple within Seven Years, Says Major Report "IndyWatch Feed Health"

By Vic Bishop

A recent viral video of a diver swimming through a sea of plastic is a stark reminder of what we are doing to the worlds oceans. Weve been reporting on this issue since 2012, watching the development of a massive gyre of plastic forming in the Pacific Ocean, devastating wildlife in the Midway Atolls.

About 300 million tons of plastic are produced each year. In the US alone, about 30+ million tons of plastic waste is dumped into the solid waste system, including various plastic containers, bags and other types of packaging, with only about 10% being recycled. [Source]

Sadly the overuse of plastic has only continued, and while a few grassroots and localized efforts have inspired a small handful of retailers to experiment with a retail model that does not use plastic packaging, projections indicate that the problem is very quickly getting much worse.

In a recent report by the UK Government Office for Science entitled Future of the Sea, a grim scenario is painted with regards to ocean pollution by plastics. Noting key long-term trends, the report states:

Plastic in the ocean is projected to triple between 2015 and 2025. Plastic does not decompose, instead breaking down into ever smaller pieces. The full eff...

18:06

This study contributes to the growing evidence that microplastic contamination is widespread even around sparsely-populated freshwater ecosystems. "IndyWatch Feed Health"

PMID:  Environ Pollut. 2017 Jun ;225:223-231. Epub 2017 Apr 2. PMID: 28376390 Abstract Title:  Microplastic contamination in Lake Winnipeg, Canada. Abstract:  Microplastics are an emerging contaminant of concern in aquatic ecosystems. To better understand microplastic contamination in North American surface waters, we report for the first time densities of microplastics in Lake Winnipeg, the 11th largest freshwater body in the world. Samples taken 2014 to 2016 revealed similar or significantly greater microplastic densities in Lake Winnipeg compared with those reported in the Laurentian Great Lakes. Plastics in the lake were largely of secondary origin, overwhelmingly identified as fibres. We detected significantly greater densities of microplastics in the north basin compared to the south basin of the lake in 2014, but not in 2015 or 2016. Mean lake-wide densities across all years were comparable and not statistically different. Scanning electron microscopy with energy dispersive X-ray spectroscopy indicated that 23% of isolated particles on average were not plastic. While the ecological impact of microplastics on aquatic ecosystems is still largely unknown, our study contributes to the growing evidence that microplastic contamination is widespread even around sparsely-populated freshwater ecosystems, and provides a baseline for future study and risk assessments.

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17:33

A review of microplastic pollution as threat to marine ecosystem and human health. "IndyWatch Feed Health"

PMID:  Environ Sci Pollut Res Int. 2017 Sep ;24(27):21530-21547. Epub 2017 Aug 16. PMID: 28815367 Abstract Title:  Microplastic pollution, a threat to marine ecosystem and human health: a short review. Abstract:  Human populations are using oceans as their household dustbins, and microplastic is one of the components which are not only polluting shorelines but also freshwater bodies globally. Microplastics are generally referred to particles with a size lower than 5 mm. These microplastics are tiny plastic granules and used as scrubbers in cosmetics, hand cleansers, air-blasting. These contaminants are omnipresent within almost all marine environments at present. The durability of plastics makes it highly resistant to degradation and through indiscriminate disposal they enter in the aquatic environment. Today, it is an issue of increasing scientific concern because these microparticles due to their small size are easily accessible to a wide range of aquatic organisms and ultimately transferred along food web. The chronic biological effects in marine organisms results due to accumulation of microplastics in their cells and tissues. The potential hazardous effects on humans by alternate ingestion of microparticles can cause alteration in chromosomes which lead to infertility, obesity, and cancer. Because of the recent threat of microplastics to marine biota as well as on human health, it is important to control excessive use of plastic additives and to introduce certain legislations and policies to regulate the sources of plastic litter. By setup various plastic recycling process or promoting plastic awareness programmes through different social and information media, we will be able to clean our sea dustbin in future.

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17:08

Microplastic particles cause intestinal damage and other adverse effects in zebrafish Danio rerio and nematode Caenorhabditis elegans. "IndyWatch Feed Health"

PMID:  Sci Total Environ. 2018 Apr 1 ;619-620:1-8. Epub 2017 Nov 11. PMID: 29136530 Abstract Title:  Microplastic particles cause intestinal damage and other adverse effects in zebrafish Danio rerio and nematode Caenorhabditis elegans. Abstract:  Microplastics have been frequently detected in aquatic environments, and there are increasing concerns about potential effects on biota. In this study, zebrafish Danio rerio and nematode Caenorhabditis elegans were used as model organisms for microplastic exposure in freshwater pelagic (i.e. water column) and benthic (i.e. sediment) environments. We investigated the toxic effects of five common types of microplastics: polyamides (PA), polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC) and polystyrene (PS) particles. Results showed no or low lethality in D. rerio after exposure for 10d at 0.001-10.0mgLmicroplastics. The PA, PE, PP and/or PVC microplastics with ~70m size caused intestinal damage including cracking of villi and splitting of enterocytes. Exposure to 5.0mgmmicroplastics for 2d significantly inhibited survival rates, body length and reproduction of C. elegans. Moreover, exposure to microplastics reduced calcium levels but increased expression of the glutathione S-transferase 4 enzyme in the intestine, which indicates intestinal damage and oxidative stress are major effects of microplastic exposure. Among 0.1, 1.0 and 5.0m sizes of fluorescently labeled PS, 1.0m particles caused the highest lethality, the maximum accumulation, the lowest Calevel in the intestine and the highest expression of glutathione S-transferase 4 in nematodes. Taken together, these findings suggest that intestinal damage is a key effect of microplastics; and that the toxicity of microplastics is closely dependent on their size, rather than their composition.

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17:00

Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. "IndyWatch Feed Health"

PMID:  Environ Pollut. 2018 Apr ;235:322-329. Epub 2018 Jan 4. PMID: 29304465 Abstract Title:  Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish. Abstract:  Microplastic (MP) are environmental pollutants and have the potential to cause varying degrees of aquatic toxicity. In this study, the effects on gut microbiota of adult male zebrafish exposed for 14 days to 100 and 1000g/L of two sizes of polystyrene MP were evaluated. Both 0.5 and 50m-diameter spherical polystyrene MP increased the volume of mucus in the gut at a concentration of 1000g/L (about 1.45610particles/L for 0.5m and 1.45610particles/L for 50m). At the phylum level, the abundance of Bacteroidetes and Proteobacteria decreased significantly and the abundance of Firmicutes increased significantly in the gut after 14-day exposure to 1000g/L of both sizes of polystyrene MP. In addition, high throughput sequencing of the 16S rRNA gene V3-V4 region revealed a significant change in the richness and diversity of microbiota in the gut of polystyrene MP-exposed zebrafish. A more in depth analysis, at the genus level, revealed that a total of 29 gut microbes identified by operational taxonomic unit (OTU) analysis were significantlychanged in both 0.5 and 50m-diameter polystyrene MP-treated groups. Moreover, it was observed that 0.5m polystyrene MP not only increased mRNA levels of IL1, IL1 and IFN but also their protein levels in the gut, indicating that inflammation occurred after polystyrene MP exposure. Our findings suggest that polystyrene MP could induce microbiota dysbiosis and inflammation in the gut of adult zebrafish.

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16:51

This Is Why Everyone Should Consume Broccoli Micro-greens and How To Easily Grow Them Yourself "IndyWatch Feed Health"

Source: This Is Why Everyone Should Consume Broccoli Micro-greens and How To Easily Grow Them Yourself For more content like this visit REALfarmacy.com.

A Japanese study of broccoli sprouts and liver function has found the sulforaphane-rich food to be highly beneficial. An extract from broccoli sprouts given to male participants was shown to improve hepatic abnormalities and overall liver function significantly. For the study, the researchers conducted a double blind, randomized placebo-controlled trial of males with fatty liver []

Source: This Is Why Everyone Should Consume Broccoli Micro-greens and How To Easily Grow Them Yourself Learn more at REALfarmacy.com - Healthy News and Information.

16:44

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice. "IndyWatch Feed Health"

PMID:  Sci Total Environ. 2018 Mar 9 ;631-632:449-458. Epub 2018 Mar 9. PMID: 29529433 Abstract Title:  Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice. Abstract:  Microplastic (MP) has become a concerning global environmental problem. It is toxic to aquatic organisms and can spread through the food chain to ultimately pose a threat to humans. In the environment, MP can interact with microbes and act as a microbial habitat. However, effects of polystyrene MP on the gut microbiota in mammals remain unclear. Here, male mice were exposed to two different sizes of polystyrene MP for 5weeks to explore its effect. We observed that oral exposure to 1000g/L of 0.5 and 50m polystyrene MP decreased the body, liver and lipid weights in mice. Mucus secretion in the gut decreased in both sizes of polystyrene MP-treated groups. Regarding the gut microbiota, at the phylum level, polystyrene MP exposure decreased the relative abundances of Firmicutes and -Proteobacteria in the feces. Furthermore, high throughput sequencing of the V3-V4 region of the 16S rRNA gene revealed significant changes in the richness and diversity of the gut microbiota in the cecums of polystyrene MP-treated mice. At the genus level, a total of 6 and 8 types of bacteria changed in the 0.5 and 50m polystyrene MP-treated groups, respectively. Furthermore, an operational taxonomic unit (OTU) analysis identified that 310 and 160 gut microbes were changed in the 0.5 and 50m polystyreneMP-treated groups, respectively. In addition, the hepatic triglyceride (TG) and total cholesterol (TCH) levels decreased in both 1000g/L 0.5 and 50m polystyrene MP-treated groups. Correspondingly, the relative mRNA levels of some key genes related to lipogenesis and TG synthesis decreasedin the liver and epididymal fat. These results indicated that polystyrene MP could modify the gut microbiota composition and induce hepatic lipid disorder in mice; while the mouse is a common mammal model, consequently, the health risks of MP to animals should not be ignored.

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16:22

These results demonstrate the potential of Tai Chi Chuan and Baduanjin exercise for the prevention of memory deficits in older adults. "IndyWatch Feed Health"

PMID:  J Alzheimers Dis. 2017 ;60(2):389-400. PMID: 28869478 Abstract Title:  Tai Chi Chuan and Baduanjin Increase Grey Matter Volume in Older Adults: A Brain Imaging Study. Abstract:  The aim of this study is to investigate and compare how 12-weeks of Tai Chi Chuan and Baduanjin exercise can modulate brain structure and memory function in older adults. Magnetic resonance imaging and memory function measurements (Wechsler Memory Scale-Chinese revised, WMS-CR) were applied at both the beginning and end of the study. Results showed that both Tai Chi Chuan and Baduanjin could significantly increase grey matter volume (GMV) in the insula, medial temporal lobe, and putamen after 12-weeks of exercise. No significant differences were observed in GMV between the Tai Chi Chuan and Baduanjin groups. We also found that compared to healthy controls, Tai Chi Chuan and Baduanjin significantly improved visual reproduction subscores on the WMS-CR. Baduanjin also improved mental control, recognition, touch, and comprehension memory subscores of the WMS-CR compared to the control group. Memory quotient and visual reproduction subscores were both associated with GMV increases in the putamen and hippocampus. Our results demonstrate the potential of Tai Chi Chuan and Baduanjin exercise for the prevention of memory deficits in older adults.

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16:01

Tai Chi exercise is conducive to alleviate cancer-related fatigue in nasopharyngeal carcinoma patients undergoing chemoradiotherapy. "IndyWatch Feed Health"

PMID:  J Pain Symptom Manage. 2018 Mar ;55(3):737-744. Epub 2017 Nov 6. PMID: 29122618 Abstract Title:  Effects of Tai Chi Exercise on Cancer-Related Fatigue in Patients With Nasopharyngeal Carcinoma Undergoing Chemoradiotherapy: A Randomized Controlled Trial. Abstract:  CONTEXT: Tai Chi exercise has been shown to improve cancer-related fatigue (CRF) and autonomic nervous system (ANS) balance in some cancer patients or survivors; however, such effects are yet to be verified in nasopharyngeal carcinoma (NPC) patients undergoing chemoradiotherapy.OBJECTIVES: To explore the effects of Tai Chi exercise on CRF in NPC patients undergoing chemoradiotherapy and then to evaluate ANS information indicated by heart rate variability parameters and their association with CRF.METHODS: A randomized controlled trial of Tai Chi exercise was conducted from January 2014 to August 2015. Participants in the Tai Chi group practiced Tai Chi a one-hour session, five sessions/week during chemoradiotherapy. Participants in the control group received usual care. The primary end points were scores of the multidimensional fatigue symptom inventory-short form (MFSI-SF). Secondary end points were heart rate variability parameters, including normalized low-frequency (nLF) power, normalized high-frequency (nHF) power, and the nLF/nHF ratio, and their association with CRF.RESULTS: One hundred fourteen patients were recruited in this study, and 83 patients completed the trial. The Tai Chi group and the control group had comparable baseline characteristics. After chemoradiotherapy, the Tai Chi group exhibited lower MFSI-SF total score and three negative subscale (general, physical, and emotional fatigue) scores and higher vigor score compared with the control group (P 

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16:00

Journal retracts study linking gut makeover to weight loss, improved health "IndyWatch Feed Health"

Over the objections of the authors, PLOS ONE has retracted a paper linking a diet designed to restore healthy gut bacteria to weight loss and other benefits. The study, published in June 2017, claimed to show that a Microbiome restoration diet improves digestion, cognition and physical and emotional wellbeing. The diet was one championed by Continue reading Journal retracts study linking gut makeover to weight loss, improved health

15:46

Tai Chi is an acceptable, holistic treatment to individuals with musculoskeletal pain and posttraumatic stress disorder. "IndyWatch Feed Health"

PMID:  J Holist Nurs. 2017 Mar 1:898010117697617. Epub 2017 Mar 1. PMID: 29172896 Abstract Title:  Tai Chi for Posttraumatic Stress Disorder and Chronic Musculoskeletal Pain: A Pilot Study. Abstract:  PURPOSE: Explore the feasibility of a Tai Chi intervention to improve musculoskeletal pain, emotion, cognition, and physical function in individuals with posttraumatic stress disorder.DESIGN: Two-phase, one-arm quasi-experimental design.METHOD: Phase 1: 11 participants completed one Tai Chi session, feasibility questionnaire, and were offered participation in Phase 2, a 12-week Tai Chi intervention. Ten participants participated in Phase 2. Pain intensity, interference, physical function scales, an emotional battery, and cognition tests were used for pre- and postintervention outcome measures. Paired t tests and thematic analysis were used for analysis.FINDINGS: In Phase 1, most felt Tai Chi would benefit health (90.9%) and expressed interest in continuing Tai Chi (6.73 out of 7). Phase 2 results showed improvement in fear-affect (raw t = -2.64, p = .03; age adjusted t = -2.90, p = .02), fear-somatic arousal (raw t = -2.53, p = .035), List Sorting Working Memory (raw t = 2.62, p = .031; age adjusted t = 2.96, p = .018), 6-Minute Walk Test ( t = 3.541, p = .008), and current level of Pain Intensity ( t = -4.00, p = .004).CONCLUSIONS: Tai Chi is an acceptable, holistic treatment to individuals with musculoskeletal pain and posttraumatic stress disorder. It may reduce pain, improve emotion, memory, and physical function.

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15:31

Qigong training can improve the blood glucose status of the type 2 DM patients and has positive effects on the management of type 2 DM. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2018 ;2018:8182938. Epub 2018 Jan 3. PMID: 29507593 Abstract Title:  The Effects of Qigong on Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis. Abstract:  Objective: The purpose of this study was to investigate the effects of Qigong on type 2 diabetes mellitus (DM) using the systematic review and meta-analysis.Methods: All prospective, randomized, controlled clinical trials published in English or Chinese and involving the use of Qigong by patients with DM were searched in 7 electronic databases from their respective inception to June 2016. The meta-analysis was conducted using the Revman 5.2. The quality of the included trials was assessed using the Jadad rating scale. Two researchers independently completed the inclusion, data extraction, and quality assessment.Results: Twenty-one trials with 1326 patients met the inclusion criteria and were reviewed. The meta-analysis demonstrated that, compared with no exercise, the Qigong had significant effects on fasting blood glucose (MD = -0.99, 95% CI (-1.23, 0.75),

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15:15

Tai Chi and Qigong shows promise in addressing cancer-related symptoms and quality of life in cancer survivors. "IndyWatch Feed Health"

PMID:  J Cancer Surviv. 2017 Dec 8. Epub 2017 Dec 8. PMID: 29222705 Abstract Title:  Tai Chi and Qigong for cancer-related symptoms and quality of life: a systematic review and meta-analysis. Abstract:  PURPOSE: This study aims to summarize and critically evaluate the effects of Tai Chi and Qigong (TCQ) mind-body exercises on symptoms and quality of life (QOL) in cancer survivors.METHODS: A systematic search in four electronic databases targeted randomized and non-randomized clinical studies evaluating TCQ for fatigue, sleep difficulty, depression, pain, and QOL in cancer patients, published through August 2016. Meta-analysis was used to estimate effect sizes (ES, Hedges' g) and publication bias for randomized controlled trials (RCTs). Methodological bias in RCTs was assessed.RESULTS: Our search identified 22 studies, including 15 RCTs that evaluated 1283 participants in total, 75% women. RCTs evaluated breast (n=7), prostate (n=2), lymphoma (n=1), lung (n=1), or combined (n=4) cancers. RCT comparison groups included active intervention (n=7), usual care (n=5), or both (n=3). Duration of TCQ training ranged from 3 to 12 weeks. Methodological bias was low in 12 studies and high in 3 studies. TCQ was associated with significant improvement in fatigue (ES=-0.53, p

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15:02

Significant effects of Tai Chi have been found in improving aerobic endurance and psychosocial well-being among coronary heart disease patients. "IndyWatch Feed Health"

PMID:  Eur J Cardiovasc Nurs. 2017 Dec 1:1474515117749592. Epub 2017 Dec 1. PMID: 29256626 Abstract Title:  Effects of Tai Chi-based cardiac rehabilitation on aerobic endurance, psychosocial well-being, and cardiovascular risk reduction among patients with coronary heart disease: A systematic review and meta-analysis. Abstract:  INTRODUCTION: Tai Chi is an attractive exercise to improve cardiovascular health. This review aimed to synthesize articles written both in Chinese and in English to evaluate the effects of Tai Chi-based cardiac rehabilitation on aerobic endurance, psychosocial well-being and cardiovascular diseases risk reduction for coronary heart diseases patients.METHODS: PRISMA guidelines were used to search major health databases to identify randomized controlled trials or non-randomized controlled clinical trials that evaluated Tai Chi intervention compared with active or non-active control groups in coronary heart disease patients. When suitable, data were pooled using a random-effects meta-analysis model.RESULTS: Thirteen studies met the inclusion criteria. Tai Chi groups showed a large and significant improvement in aerobic endurance compared with both active and non-active control interventions (standard mean difference (SMD) 1.12; 95% confidence interval (CI): 0.58-1.66; p

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14:15

Figures in cancer paper at root of newly failed compound called into question "IndyWatch Feed Health"

How much role did a potentially problematic paper play in the demise of a once-promising compound? Researchers are questioning the validity of a high-profile article, published by Nature in 2006. Although the letter is 12 years old, the concerns have current implications: It was among the early evidence used to develop a cancer compound that Continue reading Figures in cancer paper at root of newly failed compound called into question

14:14

These results suggest a beneficial effect of Tai Chi training on cognition among stroke survivors. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2017 ;2017:9134173. Epub 2017 Nov 15. PMID: 29270204 Abstract Title:  Effect of Tai Chi Training on Dual-Tasking Performance That Involves Stepping Down among Stroke Survivors: A Pilot Study. Abstract:  Descending stairs demands attention and neuromuscular control, especially with dual-tasking. Studies have demonstrated that stroke often degrades a survivor's ability to descend stairs. Tai Chi has been shown to improve dual-tasking performance of healthy older adults, but no such study has been conducted in stroke survivors. This study investigated the effect of Tai Chi training on dual-tasking performance that involved stepping down and compared it with that of conventional exercise among stroke survivors. Subjects were randomized into Tai Chi (= 9), conventional exercise (= 8), and control (= 9) groups. Those in the former two groups received 12-week training. Assessments included auditory Stroop test, stepping down test, and dual-tasking test involving both simultaneously. They were evaluated before training (time-1), after training (time-2), and one month after training (time-3). Tai Chi group showed significant improvement in the auditory Stroop test from time-1 to time-3 and the performance was significantly better than that of the conventional exercise group in time-3. No significant effect was found in the stepping down task or dual-tasking in the control group. These results suggest a beneficial effect of Tai Chi training on cognition among stroke survivors without compromising physical task performance in dual-tasking. The effect was better than the conventional exercise group. Nevertheless, further research with a larger sample is warranted.

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14:03

EPA Approves Population Control Vaccine For Deer "IndyWatch Feed Health"

The anti-vaccination community has long suspected that vaccines, on a global scale, negatively affect human fertility. Well now, the Environmental Protection Agency is using vaccines to thwart deer fertility in communities where deer populations have exploded....

The post EPA Approves Population Control Vaccine For Deer appeared first on Vaxxter.

13:48

The Ticking Time Bomb: Indias Water Crisis About to Blow Up in Our Face "IndyWatch Feed Health"

Its not yet March-end, but water woes are already un-ravelling in many parts of India.

Bengaluru, by all accounts, sits on acute water shortages akin to the ones witnessed by Cape Town. According to a statement issued by the Centre for Science and Environment (CSE) ahead of World Water Day, water table there shrunk from 10-12 metres to 76-91 metres in two decades, while the number of extraction wells went up from 5,000 to 0.45 million in 30 years.

In Vidarbhas farm-suicide-torn Yavatmal, the government medical college has sent home its outstation students, following impending water scarcity. Much of western Vidarbha faces water shortages.

A three-hour drive from there, in coal city Chandrapur, the administration has told the super thermal power project managers to be judicious through the summer in their freshwater usage, as citizens stare at massive water shortages. Its a city that lives off a small river, now turned into small puddles.

While three units of the 3340-MW power station are likely to be shut down soon, citizens would get water once in two or three days starting from the first week of April. Chandrapur is not the only city to be facing cuts. Across the country, growing number of cities will soon cut water supplies.

Nagpur, the orange city, is witnessing unprecedented water scarcity and lopsided distribution. Yet the citys water utility, a private company called the Orange City Water Distribution Company Limited, gets a national award for being the most progressive water utility in India. The joke is on Nagpurians.

In drought-prone Marathwada, poignant stories abound of rural women spending hours in search for water.

Coastal Andhra is reeling under water scarcity. In parts of south-western Madhya Pradesh, Chhattisgarh, Gujarat, Odisha and north India, next three months seem to throw a gigantic water crisis.

The Cauvery Delta region in Tamil Nadu is facing extreme water stress. The Godavari the Ganges of the South is sans water. The Krishna too, in many stretches, is but a stream of dry pebbles.

Tens of thousands of people from the arid Bundelkhand region are already boarding trains to migrate to the cities, or wherever they could, and escape both, hunger and water scarcity.

What is more, the usually ebullient Narmada that horizontally dissects the country has fallen silent in Bharuch, thanks to a mindless political decision that prompted authorities to quietly empty upstream dams into the Sardar Sarovar Project at a time when the rains were below normal.

Hundreds of sub-rivers across India have fallen permanently silent. The masses along their beds are up and marching tow...

13:47

Paul Offit MD The Pro-Vaxxers CLOWN PRINCE "IndyWatch Feed Health"

This is The Best They Can Send So lets give him a laugh Opinion by Deplorable Consumer Advocate Tim Bolen The Anti-Vaxxer movement is so strong, so powerful, and so large, in North America that not one thing, nor combination of things, the Big Pharma thunder-funded pro-vax machine does to counter them works any more. Continue reading Paul Offit MD The Pro-Vaxxers CLOWN PRINCE

The post Paul Offit MD The Pro-Vaxxers CLOWN PRINCE appeared first on BolenReport.

13:39

Mumps Outbreak Linked To Vaccines Losing Potency "IndyWatch Feed Health"

The media has hyperfocused on some recent cases of mumps across the country. The narrative, as per the usual, originally blamed the unvaccinated for their careless decision to pass on giving mumps, or MMR, vaccines...

The post Mumps Outbreak Linked To Vaccines Losing Potency appeared first on Vaxxter.

13:29

Access to clean water Indias biggest concern "IndyWatch Feed Health"

Around 63 million Indians do not have access to clean drinking water. But, according to an OECD study, every rupee invested in clean water can yield between Rs 4 and Rs 12 in economic returns. This is where Swajal Water comes in.

Over the last five years, Swajal, an IoT (Internet of Things) based clean drinking water system, has installed Water ATMs in urban slums, villages, government schools, railway stations and hospitals, across 11 states.

These machines combine Swajals patented (and cutting-edge) technology with solar energy to provide clean water that is accessible and affordable (Rs. 1 for a 300ml glass, Rs. 3 for a 500ml bottle). On the eve of World Water Day (March 22), Sharad Kohli met up with Swajal founder Vibha Tripathi, who spoke of her hopes of reaching 1,000 stations in the next year(#1000stationsmillionlives) currently, there are around 250, pan India.

How confident are you that Swajals solar-powered water purification systems can cover the whole of India?

Swajal should touch at least a million lives every day already, were at 2,50,000. In every station, about 1,000 people get impacted every day, more in the summer.

And our first machine, Im happy to say, is still functioning (in Mewat Model School, Nuh, Mewat). We want to grow and consolidate in India, and to explore new markets, and also to explore new lines of business, maybe larger systems which can cater to a complete town. Weve received a query from Kashmir, so were planning to move there.

What is Indias biggest concern lack of water or lack of clean drinking water?

Its a no-brainer that many of the public health problems India faces can be solved by ensuring that everyone has access to clean drinking water. Lack of water may be a problem in some areas, like Rajasthan. But almost all of India gets some water, through rainfall or from rivers. Lack of clean drinking water is another issue altogether, because of pollution and over-usage. Pollution shows (up) in places like Punjab, where there is ample water but there are pesticides.

Over-harvesting shows (up) in strange fashion, such as extreme fluoride in Rajasthan, and when you go deeper into the water table, you have more arsenic, etc. Clean drinking water is very difficult to find, especially in cities. As the Ganges flows out of Rishikesh and Haridwar, each city and town pollutes it. So, by the time it reaches West Bengal, it is like a drain!

Why is it that, 70 years after Independence, access to clean drinking water remains a problem?

Quality of water has been deteriorating over the years. I was born in Indepen...

13:12

Quarterback sacks mean less plaque for kids across Wisconsin "IndyWatch Feed Health"

PLOVER, WIS. (WSAW) A partnership between the Green Bay Packers and Delta Dental is allowing kids across Wisconsin access to free dental care.

For each of the 43 quarterback sacks the Packers recorded during the 2017/18 season, a donation was made to the Seal-A-Smile program, which provides free oral health screenings, fluoride varnish and sealants to elementary students.

Delta Dental presented a check for $11,075 to the program at Roosevelt Elementary School in Plover Wednesday afternoon. The school was also presented a check for $1,000.

After the check presentation the students opened wide for dental screenings and fluoride varnish.

The Seal-A-Smile program will screen about 65,000 students and will place sealants on about 30,000 students in 2018.

*Original article online at http://www.wsaw.com/content/news/Quarterback-sacks-mean-less-plaque-for-kids-across-Wisconsin-477557663.html

13:08

Maharashtra: Fluoride levels "IndyWatch Feed Health"

Excerpts:

Nagpur: In almost all the districts of the state, nitrate pollution has become a major threat to groundwater. It is believed to cause blue baby syndrome.
The monitored data by Central Ground Water Board (CGWB) shows that the concentration of nitrate is well above the permissible limit all over the state. As per the Bureau of Indian Standards (BIS), the permissible limit for nitrate is 45 mg/litres.

Apart from nitrate, high concentration of fluoride in some parts of the state is another cause of worry. While its permissible limit is 1 mg/litres, it is present up to 2.42 mg/l in certain parts.

The report shows that at a monitored site in Salori in Chandrapur, the concentration of fluoride was 2.29 mg/l. At a site in Allapalli in Gadchiroli, it was 2.08 mg/l while in Ramdespeth, Nagpur, it was 2.19 mg/l. At three wells in Yavatmal, the concentration of fluoride has been found very high and locals have been directed not to use that water, said Sharma.

Though fluoride presence in groundwater is mainly due to presence of specific minerals in the geological formation, studies revealed that anthropogenic activities like using fertilizers and pesticides containing phosphates, discharge of untreated industrial effluents and unabated over-exploitation of groundwater are also responsible for high fluoride levels which can lead to fluoride poisoning and skeleton and dental fluorosis.

Fluoride Facts

CGWBs 2016-17 report shows presence of fluoride in state. The permissible limit of fluoride (as per Bureau of Indian Standards): Accptable limit 1 mg/l; Max permissible limit 1.5 mg/l

Chandrapur |Well above maximum permissible limit in 13 monitored sites. Highest value was 2.29 mg/l recorded in Salori

Dhule | Recorded 1.60 and 1.01 mg/l at two sites

Gadchiroli | At sites in Allapalli and Chaudampalli, was 2.08 and 1.20 mg/l, respectively

Gondia | At two sites, was 1.04 and 1.01 mg/l

Hingoli | Was 1.10 mg/l at one site

Nagpur | At 4 sites, was more than limit. At Koradi & Lonara, it was 1.17 and 101 mg/l

Ratnagiri| Was 1.09 mg/l at a site

Sindhudurg | Was 1.10 mg/l at a site

*Original article titled Nitrate pollution a big cause of worry online at...

13:03

Tai Chi seems a good choice for coronary disease rehabilitation in improving cardiorespiratory fitness. "IndyWatch Feed Health"

PMID:  Front Physiol. 2017 ;8:1091. Epub 2018 Jan 4. PMID: 29354065 Abstract Title:  The Effect of Tai Chi on Cardiorespiratory Fitness for Coronary Disease Rehabilitation: A Systematic Review and Meta-Analysis. Abstract:  Tai Chi that originated in China as a martial art is an aerobic exercise with low-to-moderate intensity and may play a role in cardiac rehabilitation.To systematically review the effect of Tai Chi on cardiorespiratory fitness for coronary disease rehabilitation.We performed a search for Chinese and English studies in the following databases: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, Chinese Biomedical Literature Database, China Knowledge Resource Integrated Database, Wanfang Data, and China Science and Technology Journal Database. The search strategy included terms relating to or describing Tai Chi and coronary disease, and there were no exclusion criteria for other types of diseases or disorders. Further, bibliographies of the related published systematic reviews were also reviewed. The searches, data extraction, and risk of bias (ROB) assessments were conducted by two independent investigators. Differences were resolved by consensus. RevMan 5.3.0 was used to analyze the study results. We used quantitative synthesis if the included studies were sufficiently homogeneous and performed subgroup analyses for studies with different control groups. To minimize bias in our findings, we used GRADEpro to grade the available evidence.Five studies were enrolled-two randomized controlled trials (RCTs) and three nonrandomized controlled trials (N-RCTs)-that included 291 patients. All patients had coronary disease. ROB assessments showed a relatively high selection and detection bias. Meta-analyses showed that compared to other types of low- or moderate-intensity exercise, Tai Chi could significantly improve VOmax [MD = 4.71, 95% CI (3.58, 5.84),

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12:49

Meadville: Minor changes at water authoritys reorganization meeting "IndyWatch Feed Health"

Excerpt:

The members of the MAWA [Meadville Area Water Authority] board are appointed by Meadville City Council. The makeup of the board and the process of selecting its members was the focus of more attention than usual during early and mid-2017 when the board controversially approved fluoridation by a 3-2 vote.

Tommy Thompson, MAWAs consulting engineer, reported that the authority is still waiting to hear from Pennsylvania Department of Environmental Protection on its fluoridation permit application submitted several months ago.

*Original article online at http://www.meadvilletribune.com/news/local_news/minor-changes-at-water-authority-s-reorganization-meeting/article_28fabf7f-f3d3-5594-b605-42fa44ac8526.html

12:43

Tai Chi improves cognition and plasma BDNF in older adults with mild cognitive impairment "IndyWatch Feed Health"

PMID:  Neurorehabil Neural Repair. 2018 Feb ;32(2):142-149. Epub 2018 Jan 20. PMID: 29353543 Abstract Title:  Tai Chi Improves Cognition and Plasma BDNF in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial. Abstract:  BACKGROUND: Effects of Tai Chi (TC) on specific cognitive function and mechanisms by which TC may improve cognition in older adults with amnestic mild cognitive impairment (a-MCI) remain unknown.OBJECTIVE: To examine the effects of TC on cognitive functions and plasma biomarkers (brain-derived neurotrophic factor [BDNF], tumor necrosis factor- [TNF-], and interleukin-10 [IL-10]) in a-MCI.METHODS: A total of 66 older adults with a-MCI (mean age = 67.9 years) were randomized to either a TC (n = 33) or a control group (n = 33). Participants in the TC group learned TC with a certified instructor and then practiced at home for 50 min/session, 3 times/wk for 6 months. The control group received educational material that covered information related to cognition. The primary outcome was cognitive performance, including Logical Memory (LM) delayed recall, Block Design, Digit Span, and Trail Making Test B minus A (TMT B-A). The secondary outcomes were plasma biomarkers, including BDNF, TNF-, and IL-10.RESULTS: At the end of the trial, performance on the LM and TMT B-A was significantly better in the TC group compared with the control group after adjusting for age, gender, and education ( P

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12:33

Combined music and Tai Chi reduced depressive symptoms among community-dwelling older persons. "IndyWatch Feed Health"

PMID:  Issues Ment Health Nurs. 2018 Feb 13:1-5. Epub 2018 Feb 13. PMID: 29436896 Abstract Title:  The Impact of Combined Music and Tai Chi on Depressive Symptoms Among Community-Dwelling Older Persons: A Cluster Randomized Controlled Trial. Abstract:  BACKGROUND: The effectiveness of pharmacological treatment may be limited in older persons. Several studies using Tai Chi or music therapy separately confirmed positive effects in the reduction of depressive symptoms. We conducted a cluster randomized controlled trial to evaluate the possible synergistic effect of combined music and Tai Chi on depressive symptoms.METHODS: One hundred and seven older adults with mild to moderate depressive symptoms were recruited from Ya'an city. Fifty-five participants were cluster randomized to combined music and Tai Chi group for three months, while the other fifty-two individuals were randomized to the control group that entailed routine health education delivered monthly by community nurses. The primary outcome of depressive symptoms was measured with the Geriatric Depression Scale (GDS) at baseline and monthly for three months.RESULTS: At three-month follow-up, a statistically significant improvement in depressive symptoms was found in the intervention group compared with control group (F(3,315) = 69.661, P

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12:09

A review revealing the neural mechanisms underlying the beneficial effects of Tai chi. "IndyWatch Feed Health"

PMID:  Am J Chin Med. 2018 ;46(2):231-259. PMID: 29542330 Abstract Title:  Revealing the Neural Mechanisms Underlying the Beneficial Effects of Tai Chi: A Neuroimaging Perspective. Abstract:  Tai Chi Chuan (TCC), a traditional Chinese martial art, is well-documented to result in beneficial consequences in physical and mental health. TCC is regarded as a mind-body exercise that is comprised of physical exercise and meditation. Favorable effects of TCC on body balance, gait, bone mineral density, metabolic parameters, anxiety, depression, cognitive function, and sleep have been previously reported. However, the underlying mechanisms explaining the effects of TCC remain largely unclear. Recently, advances in neuroimaging technology have offered new investigative opportunities to reveal the effects of TCC on anatomical morphologies and neurological activities in different regions of the brain. These neuroimaging findings have provided new clues for revealing the mechanisms behind the observed effects of TCC. In this review paper, we discussed the possible effects of TCC-induced modulation of brain morphology, functional homogeneity and connectivity, regional activity and macro-scale network activity on health. Moreover, we identified possible links between the alterations in brain and beneficial effects of TCC, such as improved motor functions, pain perception, metabolic profile, cognitive functions, mental health and sleep quality. This paper aimed to stimulate further mechanistic neuroimaging studies in TCC and its effects on brain morphology, functional homogeneity and connectivity, regional activity and macro-scale network activity, which ultimately lead to a better understanding of the mechanisms responsible for the beneficial effects of TCC on human health.

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12:00

Misleading Headlines Re Tetyana Obukhanychs 2015 Open Letter to Legislators "IndyWatch Feed Health"

March 22, 2017 During the SB277 battle in California, I happened to catch sight of an open letter to the California state legislators written by immunologist Tetyana Obukhanych, Ph.D. The letter explained why there was no scientific rationale for forcing Continue reading

The post Misleading Headlines Re Tetyana Obukhanychs 2015 Open Letter to Legislators appeared first on The Thinking Moms' Revolution.

11:03

A Quiet Drug Problem Among the Elderly "IndyWatch Feed Health"

From The New York Times: Use of benzodiazepines has risen among seniors despite their increased vulnerability to the drugs adverse effects.

Set aside the opioid issue, said Michael Schoenbaum, an epidemiologist at the National Institutes for Health. Way too many older Americans are getting benzos. And of those, many more than half are getting them for prolonged periods. Thats just bad practice. They have serious consequences.

Probably the most serious: falls and fractures, already a common danger for older people, because benzos can cause dizziness. Theyre also associated with auto accidents, given that they cause drowsiness and fatigue.

Moreover, they have a negative effect on memory and other cognitive function, says Dr. Donovan Maust, a psychiatrist at the Veterans Affairs Ann Arbor Health Care System. Some studies have shown an association with dementia, though experts call the evidence to date inconclusive.

Article 

11:03

#SaidNoMother Campaign on Facebook Addresses Vaccine Injury "IndyWatch Feed Health"

Joshua Coleman has started a hashtag on Facebook called "#SaidNoMother in which Mothers and Fathers are creating memes with their child's vaccine injury story expressed in deliberately crushing fashion. If anyone can read them and not feel at least a...

11:02

Yale Neuroscientists Debunked the Idea That Anyone is Normal "IndyWatch Feed Health"

From Quartz: A new study by Yale neuroscientists proves that there is no universal, unconditionally optimal profile of brain functioning. This means that differences often categorized as psychiatric illness may instead be strengths, depending on a persons context.

In other words, trying to define people one way from a psychiatric perspective is a failure of imagination and opportunity, which hobbles people rather than empowering them to inhabit their full selves. Classic psychiatry categorizes people in limiting, linear ways, while the world is inherently wide-ranging, according to the researchers.

They propose instead that each individual be assessed and understood singularly from a psychiatric perspective, but according to a wide range of fluctuating behaviors and tendencies.

Article 

11:01

Why Nutritional Psychiatry is the Future of Mental Health "IndyWatch Feed Health"

From The Independent: The role that nutrition can play in improving our mental health is often overlooked. Research suggests that we should devote more resources to dietary approaches to emotional distress.

There is currently much debate over the effectiveness of antidepressants. The use of food supplements offer an alternative approach that has the potential to make a significant difference to the mental health of all age groups.

The emerging scientific evidence suggests that there should be a bigger role for nutritional psychiatry in mental health within conventional health services. If the burden of mental ill health is to be reduced, GPs and psychiatrists need to be aware of the connection between food, inflammation and mental illness.

Article 

11:00

Schools Becoming the New Mental Health Institutions "IndyWatch Feed Health"

Note: Here are some of Anne's collected media stories about the changes in schooling in the First World. We had a 16 year old female make a credible threat in my town on the day of the Walk Out. A...

10:01

The Concerned Parents Project March 22nd "IndyWatch Feed Health"

You may decide that you cant do enough to help your child reduce his or her experience of distress all by yourself. Where should you turn for help?

 

It amounts to a very different decision to take your child to a child psychologist whose speciality is talk and who uses techniques like play therapy or to take your child to a psychiatrist who routinely diagnoses mental disorders and who then prescribes medication. There are many types of helpers out therepeer counselor, school counselor, mentor, dietician, family therapist, residential treatment specialist, clinical psychologist, psychotherapist, psychiatristand each comes at human challenges from a different angle. Educate yourself as to what these different service providers actually provide and decide which sort of service makes the most sense to you.

Lets say that your teenager is getting poor grades, doesnt have friends, is morose, describes life as meaningless, and experiences great social anxiety. Will you aim for help for one of these, say by searching out a tutor to help with his math difficulties or a psychotherapist for his social anxiety, will you presume that these are all connected under the banner of difficult teenage years and press for peer counseling or a coping skills workshop, or will you go down the road of psychiatry, which will lead to a mental disorder diagnosis and chemicals? How you (and your child) conceptualize Whats going on? and What might help? will send you in one direction or another. Stay steady that the two questions Whats going on? and What might help? matter, even as you feel pulled to throw up your hands and aim your child at the first putative helper that pops to mind. Seriously considering these questions, even if you cant land on perfect answers, will remind you that you have choices, that one choice might prove better than another choice, and that when you decide to try out one sort of help that doesnt preclude you from also trying out some other sort of help.

*****

Read the Concerned Parents Project Introductory Post

Read Question 21

To get in touch or to share your feedback, please email us

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06:00

Abdominal Obesity Linked to Anxiety and Depression "IndyWatch Feed Health"

By Dr. Mercola

Depression and anxiety are two leading mental health problems that have seen a dramatic rise in incidence in recent years. Worldwide, depression is now the leading cause of ill health and disability,1,2 with rates rising 18 percent in the decade between 2005 and 2015.3

In the U.S., more than 16 million people struggle with the condition, and 1 in 4 women in their 40s and 50s are on antidepressant drugs.4 This, despite the fact that antidepressants have been proven to work no better than placebo.5,6,7,8 Eight9 to 14 percent10 of pregnant women are also on antidepressants, even though studies have linked their use during pregnancy to birth defects.11

Meanwhile, data from the National Institute of Mental Health suggests the prevalence of anxiety disorders which include generalized anxiety disorder, social anxiety and panic disorder may be as high as 40 million in the U.S. about 18 percent of the population over the age of 18 making it the most common mental illness in the nation,12,13 and 800 percent more prevalent than all forms of cancer....

What Are Some of the Best Brain-Boosting Foods? "IndyWatch Feed Health"

By Dr. Mercola

Your brain is like a sponge, soaking up not only the information around you on a daily basis but also the vitamins, minerals, antioxidants and other phytochemicals in the food you eat. The more you eat a diet based on whole, healthy foods, the more your brainpower will soar, even to the point of staving off age-related cognitive decline and other brain disorders. While eating real foods is key, there are some superstars that stand above the rest.

By planning your meals to include the brain-boosting foods that follow, youll be providing the fuel your brain needs to not only stay healthy in the future but also function optimally today, bringing with it increased productivity, focus and a creative edge.

Six Top Brain-Boosting Foods to Include in Your Diet

Healthy Fish

Small cold-water fish that are rich in animal-based omega-3 fats but have a low risk of contamination are among your best choices for healthy fish. This includes anchovies, sardines, mackerel, herring and wild-caught Alaskan salmon. The omega-3 they contain is vital to your brain, helping to fight inflammation and offer numerous protections to your brain cells.

For instance, a study in the journal Neurology found "older women with the highest levels of omega-3 fats had better preservation of their brain as they aged than those with the lowest levels, which might mean they would maintain better brain function for an extra year or two."1 In separate research, when boys were given an omega-3 supplement, there were significant increases in the activation of the dorsolateral prefrontal cortex part of the brain.2

This is an area of your brain associated with working memory. They also noticed changes in other parts of the brain, including the occipital cortex (the visual processing center) and the cerebellar cortex (which plays a role in motor control). In addition, older adults with memory complaints who consumed the omega-3 fat docosahexaenoic acid (DHA), alone or in combination with another omega-3 fat eicosapentaenoic acid (EPA), had improved memory....

Why Trying Cloudberry Is Worth It "IndyWatch Feed Health"

Bright-colored berries, popularly eaten on their own or added to various dishes, are known to deliver vital health benefits. Aside from the usual strawberries, blueberries and blackberries, there are more berry varieties out there, some of which you might have not even heard of. Cloudberry is one interesting example.

What Is Cloudberry?

An Arctic, north-temperate species, cloudberry (Rubus chamaemorus L.) comes from the Rosaceae (rose family) and can be found growing wild in cool or cold environments. In North America, you can see it in regions like Newfoundland, Alaska and British Columbia. In countries like Norway, Finland, England, Sweden and Russia, cloudberry also thrives well.1

A low-growing perennial, cloudberry typically grows in boggy and open tundra or forests. The plant is dioecious, meaning there are male or female cloudberry plants, with the latter known to produce the fruits.2

Cloudberry fruits form on very slender stems that arent more than 2 to 8 inches high. According to the University of Alaska Fairbanks Cooperative Extension Service, cloudberry plants can be distinguished by their two to three circular leaves, each with rounded lobes and toothed edges, alongside a single white, five-petal flower. Meanwhile, the small and round berry itself is composed of six to eight drupelets.3

An unripe cloudberry fruit is hard, red and sour, but as it ripens, it softens and lightens, turns either a rosy peach or amber hue and develops a sweet flavor. The taste is tart but floral, and can be described as a combination of red currant and raspberry.4

Cloudberry retains its distinct shape because of its juice. When the juice oozes out, a small percentage of fiber (found in the thin skin) and a number of seeds remain.5 You can use these seeds to grow new cloudberry plants.6 Unfortunately, cloudberry isnt widely cultivated, so it isnt exported and may not be available in many areas around the world.7

Health Benefits...

05:01

A Tale of Two Studies "IndyWatch Feed Health"

It often seems that psychiatry today, as an institution, is like a miner in the mid-1800s desperately sifting for gold. The biological psychiatry revolution has clearly failed, and with increasing evidence that psychiatric drugs do more harm than good over the long term, the field often seems focused on sifting through the mounds of research data it has collected, eager to at last sit up and cry, heres a shiny speck of gold! Our drugs do work!

We saw that recently with the Cipriani study published in the Lancet, which led to headlines in British newspapers proclaiming the wonders of antidepressants. While even a quick look at the study revealed that it provided nothing new, and that the evidence base for assessing the risks and benefits of antidepressants hadnt changed, the soundbite headlines were the holler heard round the world.

Lancet Psychiatry is back this month with another such holler, which is now making its way around psychiatric circles. The study tells of how discontinuing antipsychotic medication following recovery from an initial episode of psychosis increases the risk of poor long-term clinical outcome. That is a conclusion certain to provide comfort to prescribers today, as it will be seen as evidence that there is no need to change their current practices, which emphasize continual drug maintenance.

However, there is a newly published study in the Journal of the Norwegian Medical Association that tells of an opposite result. The Norwegian researchers report that a treatment they call basal exposure therapy has helped chronic patients taper from their medications (either down to a lower dose or off psychiatric drugs altogether), and that the best long-term outcomes are seen in those who got completely off the drugs. Unfortunately, I am pretty sure this one wont soon be circulating in psychiatric circles.

On the surface, it might seem that these two studies have focused on the same question: how does an effort to discontinue from antipsychotics and other psychiatric drugs affect long-term outcomes? But, in fact, the studies had two very different purposes.

The first study was designed to test whether maintenance drug therapy was good for patients, with that proof, in large part, dependent on patients withdrawn from their medications faring poorly. The second study was designed to assess whether discontinuation could be done successfully and provide a long-term benefit.

Its a tale of two studies, and a quick review of both helps frame an important ethica...

01:35

Robert F. Kennedy, Jr. Addresses Capitol Hill on Vaccine Safety Issues "IndyWatch Feed Health"

number-of-vaccines-vs-chronic-illness-prevalence

World Mercury Project Note: Last week, 15 dedicated childrens health and medical choice advocates joined Robert F. Kennedy, Jr. on Capitol Hill to fulfill our promise to the community to provide crucial vaccine safety information to every member of Congress.

Meetings with Congressional Members, Senators, and staff took place over a four-day time period to explain WMPs six-step Vaccine Safety Project that details the actions necessary to introduce sound science and transparency to our vaccination program.

Federally elected officials can no longer ignore the chronic health conditionstied in no small part to adverse vaccine reactionsthat currently affect over half of our nations children.

Not only are these officials now aware of the conflicts of interest and inadequate science upon which the vaccine program is built, but they have been given a common-sense plan for enacting desperately needed changes that puts childrens health first.

03-13-VSP-ATTENDEES

Congress Receives Vaccine Safety Project Details Including Actions Needed for Sound Science and Transparency

by the World Mercury Project Team

The long-term health effects of our vaccine program are inadequately studied and our regulatory bodies are conflicted. Childhood health epidemics have mushroomed along with the childhood vaccine schedule.

Vaccines contain many ingredients, some of which are known to be neurotoxic, carcinogenic and cause autoimmunity. Vaccines injuries can and do happen. The National Vaccine Injury Compensation Program of Healt...

01:02

Robert F. Kennedy, Jr. Addresses Capitol Hill on Vaccine Safety Issues "IndyWatch Feed Health"

number-of-vaccines-vs-chronic-illness-prevalence

World Mercury Project Note: Last week, 15 dedicated childrens health and medical choice advocates joined Robert F. Kennedy, Jr. on Capitol Hill to fulfill our promise to the community to provide crucial vaccine safety information to every member of Congress.

Meetings with Congressional Members, Senators, and staff took place over a four-day time period to explain WMPs six-step Vaccine Safety Project that details the actions necessary to introduce sound science and transparency to our vaccination program.

Federally elected officials can no longer ignore the chronic health conditionstied in no small part to adverse vaccine reactionsthat currently affect over half of our nations children.

Not only are these officials now aware of the conflicts of interest and inadequate science upon which the vaccine program is built, but they have been given a common-sense plan for enacting desperately needed changes that puts childrens health first.

03-13-VSP-ATTENDEES

Congress Receives Vaccine Safety Project Details Including Actions Needed for Sound Science and Transparency

by the World Mercury Project Team

The long-term health effects of our vaccine program are inadequately studied and our regulatory bodies are conflicted. Childhood health epidemics have mushroomed along with the childhood vaccine schedule.

Vaccines contain many ingredients, some of which are known to be neurotoxic, carcinogenic and cause autoimmunity. Vaccines injuries can and do happen. The National Vaccine Injury Compensation Program of Health a...

00:18

Vitamins C and K3 could be used to sensitize leukemia lymphocytes to everolimus and barasertib. "IndyWatch Feed Health"

PMID:  Anticancer Res. 2018 03 ;38(3):1407-1414. PMID: 29491065 Abstract Title:  Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib. Abstract:  BACKGROUND/AIM: Recent studies provided convincing evidence for the anticancer activity of combined application of vitamin C and pro-vitamin K3 (menadione). The molecular pathways underlying this process are still not well established. The present study aimed to investigate the effect of the combination of vitamin C plus pro-vitamin K3 on the redox status of leukemia and normal lymphocytes, as well as their sensitizing effect for a variety of anticancer drugs.MATERIALS AND METHODS: Cytotoxicity of the substances was analyzed by trypan blue staining and automated counting of live and dead cells. Apoptosis was analyzed by fluorescein isothiocyanate-annexin V test. Oxidative stress was evaluated by the intracellular levels of reactive oxygen and nitrogen species and protein-carbonyl products.RESULTS: Combined administration of 300M vitamin C plus 3 M pro-vitamin K3 reduced the viability of leukemia lymphocytes by ~20%, but did not influence the viability of normal lymphocytes. All combinations of anticancer drug plus vitamins C and K3 were characterized by synergistic cytotoxicity towards Jurkat cells, compared to cellstreated with drug alone for 24 h. In the case of barasertib and everolimus, this synergistic cytotoxicity increased within 72 hours. It was accompanied by strong induction of apoptosis, but a reduction of level of hydroperoxides and moderately increased protein-carbonyl products in leukemia cells.CONCLUSION: Leukemia lymphocytes were more sensitive to combined administration of anticancer drug (everolimus or barasertib) plus vitamins C and K3, compared to normal lymphocytes. The combination of vitamin C plus K3 seems to be a powerful redox system that could specifically influence redox homeostasis of leukemia cells and sensitize them to conventional chemotherapy.

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Wednesday, 21 March

23:57

Centella asiatica and asiatic acid can be used as antifibrotic agents. "IndyWatch Feed Health"

PMID:  J Investig Clin Dent. 2017 May ;8(2). Epub 2016 Feb 3. PMID: 26840561 Abstract Title:  Antifibrotic effect of Centella asiatica Linn and asiatic acid on arecoline-induced fibrosis in human buccal fibroblasts. Abstract:  AIM: The aim of the present study was to investigate the in vitro antifibrogenic effects of Centella asiatica Linn (CA) and its bioactive triterpene aglycone asiatic acid (AA) on arecoline-induced fibrosis in primary human buccal fibroblasts (HBF).METHODS: An ethanolic extract of CA was prepared, and AA was purchased commercially. High-performance thin-layer chromatography (HPTLC) was performed to quantify AA in the CA extract; colorimetric assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) was performed to determine an half-maximal inhibitory concentration. HBF were cultured and stimulated with arecoline. The inhibitory effects of CA and AA at different concentrations were assessed using gene-expression studies on fibrosis-related markers: transforming growth factor-1, collagen 1 type 2, and collagen 3 type 1. The stimulatory effect of arecoline and the inhibitory effect of AA on fibroblast morphology and extracellular matrix were assessed qualitatively using Masson trichrome stain.RESULTS: The HPTLC analysis determined 1.2% AA per 100 g of CA extract. Arecoline produced a concentration-dependent increase in the fibrotic markers, treatment with CA significantly downregulated fibrotic markers at higher concentrations, and AA downregulated at lower concentrations. Arecoline altered fibroblast morphology and stained strongly positive for collagen, and AA treatment regained fibroblast morphology with faint collagen staining.CONCLUSION: CA and AA can be used as antifibrotic agents.

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23:49

Asiatic acid may represent a potential therapeutic agent for ovarian cancer. "IndyWatch Feed Health"

PMID:  Pharm Biol. 2016 Nov ;54(11):2377-2382. Epub 2016 Mar 17. PMID: 26984021 Abstract Title:  Asiatic acid exerts anticancer potential in human ovarian cancer cells via suppression of PI3K/Akt/mTOR signalling. Abstract:  Context Asiatic acid, a triterpenoid compound extracted from the tropical medicinal plant Centella asiatica (Family: Apiaceae), has exhibited various biological activities. Objective This study was performed to investigate the cytotoxic effects of asiatic acid on human ovarian cancer cells. Materials and methods SKOV3 and OVCAR-3 ovarian cancer cells were exposed to different concentrations of asiatic acid (10-100g/mL) for 72 or 48h. Cell viability, colony formation, cell cycle distribution, apoptotic response were examined. Involvement of the phosphoinositide 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway was tested. Results At the concentration of 40g/mL, asiatic acid causedabout 50% reduction in the viability of ovarian cancer cells, but had little effect on the viability of normal human ovarian epithelial cells. Asiatic acid at 10g/mL reduced colony formation of ovarian cancer cells by 25-30%. Asiatic acid-treated cells showed a cell cycle arrest at the G0/G1 phase and 7- to 10-fold increase in apoptosis. The phosphorylation levels of PI3K, Akt and mTOR were remarkably lower in asiatic acid-treated cells. Overexpression of constitutively active Akt partially reversed the cytotoxic effects of asiatic acid, as evidenced by increased cell viability and colonyformation. Furthermore, knockdown of Akt mimicked the growth-suppressive activity of asiatic acid. Discussion and conclusion These results provide first the evidence for the anticancer potential of asiatic acid in ovarian cancer cells, partially via inactivation of the PI3K/Akt/mTOR pathway. Asiatic acid may represent a potential therapeutic agent for ovarian cancer.

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23:27

Recent updates in neuroprotective and neuroregenerative potential of Centella asiatica. "IndyWatch Feed Health"

PMID:  Malays J Med Sci. 2016 Jan ;23(1):4-14. PMID: 27540320 Abstract Title:  Recent Updates in Neuroprotective and Neuroregenerative Potential of Centella asiatica. Abstract:  Centella asiatica, locally well known in Malaysia as pegaga, is a traditional herb that has been used widely in Ayurvedic medicine, traditional Chinese medicine, and in the traditional medicine of other Southeast Asian countries including Malaysia. Although consumption of the plant is indicated for various illnesses, its potential neuroprotective properties have been well studied and documented. In addition to past studies, recent studies also discovered and/or reconfirmed that C. asiatica acts as an antioxidant, reducing the effect of oxidative stress in vitro and in vivo. At the in vitro level, C. asiatica promotes dendrite arborisation and elongation, and also protects the neurons from apoptosis. In vivo studies have shown that the whole extract and also individual compounds of C. asiatica have a protective effect against various neurological diseases. Most of the in vivo studies on neuroprotective effects have focused on Alzheimer's disease, Parkinson's disease, learning and memory enhancement, neurotoxicity and other mental illnesses such as depression and anxiety, and epilepsy. Recent studies have embarked on finding the molecular mechanism of neuroprotection by C. asiatica extract. However, the capability of C. asiatica in enhancing neuroregeneration has not been studied much and is limited to the regeneration of crushed sciatic nerves and protection from neuronal injury in hypoxia conditions. More studies are still needed to identify the compounds and the mechanism of action of C. asiatica that are particularly involved in neuroprotection and neuroregeneration. Furthermore, the extraction method, biochemical profile and dosage information of the C. asiatica extract need to be standardised to enhance the economic value of this traditional herb and to accelerate the entry of C. asiatica extracts into modern medicine.

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23:15

Centella asiatica may be useful in preventing liver damage. "IndyWatch Feed Health"

PMID:  Mol Med Rep. 2016 Nov ;14(5):4521-4528. Epub 2016 Oct 5. PMID: 27748812 Abstract Title:  Protective effects of Centella asiatica leaf extract on dimethylnitrosamineinduced liver injury in rats. Abstract:  Oxidative stress in liver injury is a major pathogenetic factor in the progression of liver damage. Centella asiatica (L.) Urban, known in the United States as Gotu kola, is widely used as a traditional herbal medicine in Chinese or Indian Pennywort. The efficacy of Centella asiatica is comprehensive and is used as an antiinflammatory agent, for memory improvement, for its antitumor activity and fortreatment of gastric ulcers. The present study investigated the protective effects of Centella asiatica on dimethylnitrosamine (DMN)induced liver injury in rats. The rats in the treatment groups were treated with Centella asiatica at either 100 or 200 mg/kg in distilled water (D.W) or with silymarin (200 mg/kg in D.W) by oral administration for 5 days daily following intraperitoneal injections of 30 mg/kg DMN. Centella asiatica significantly decreased the relative liver weights in the DMNinduced liver injury group, compared with the control. The assessment of liver histology showed that Centella asiatica significantly alleviated mass periportal  bridging necrosis, intralobular degeneration and focal necrosis, with fibrosis of liver tissues. Additionally, Centella asiatica significantly decreased the level of malondialdehyde, significantly increased the levels of antioxidant enzymes, including superoxide dismutase, glutathione peroxidase and catalase, and may have provided protection against the deleterious effects of reactive oxygen species. In addition, Centella asiatica significantly decreased inflammatory mediators, including interleukin (IL)1, IL2,IL6, IL10, IL12, tumor necrosis factor, interferon and granulocyte/macrophage colonystimulating factor. These results suggested that Centella asiatica had hepatoprotective effects through increasing the levels of antioxidant enzymes and reducing the levels of inflammatory mediators in rats with DMNinduced liver injury. Therefore, Centella asiatica may be useful in preventing liver damage.

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22:14

Centella asiatica leaf extract may be useful as an alternative therapy against H. pylori infection. "IndyWatch Feed Health"

PMID:  Prev Nutr Food Sci. 2016 Sep ;21(3):197-201. Epub 2016 Sep 30. PMID: 27752495 Abstract Title:  andAnti-Activities ofLeaf Extract. Abstract:  infection is associated with an increased risk of developing upper gastrointestinal tract diseases. However, treatment failure is a major cause of concern mainly due to possible recurrence of infection, the side effects, and resistance to antibiotics. The aim of this study was to investigate the activities ofleaf extract (CAE) againstbothand. The minimum inhibitory concentrations (MICs) against 55 clinically isolated strains ofwere tested using an agar dilution method. The MICs of CAE ranged from 0.125 mg/mL to 8 mg/mL, effectiveness in inhibitinggrowth was 2 mg/mL. The anti-effects of CAEwere also examined in-infected C57BL/6 mice. CAE was orally administrated once daily for 3 weeks at doses of 50 mg/kg and 250 mg/kg. CAE at the 50 mg/kg dose significantly reducedcolonization in mice gastric mucosa. Our study provides novel insights into the therapeutic effects of CAE againstinfection, and it suggests that CAE may be useful as an alternative therapy.

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21:59

Cloudy Urine: What Does It Mean and Is It a Reason for Concern? "IndyWatch Feed Health"

There is a lot that the color of urine can tell about your health, and passing cloudy urine could mean that you are dehydrated or have an infection. Noticing cloudy urine once in a while is rarely a reason for concern. Usually, the symptoms go away quickly and your urine returns to the light straw-yellow color it should be.

Some medical conditions can cause your pee to appear consistently cloudy and, possibly, foamy as well. For example, urinary tract infections, kidney infections, kidney stones, or bacterial infections can all cause cloudy urine. These reasons for foggy-looking pee could give your urine a cloudy yellow color, or it could look like dark cloudy urine with a strong ammonia-like smell.

If a medical condition is making your pee cloudy, you might also have other symptoms like flank pain, a burning sensation when peeing, pressure in the lower abdomen, or a persistent urge to urinate. In cases of a mild urinary infection, there are many effective home remedies that can help to kill off the infections and stop your pee being cloudy and smelly.

In this article, you will learn what it can mean if you have cloudy urine as well as other symptoms of an infection in your urinary system. At the end of the article, I will discuss what it means if you have cloudy urine when pregnant and what to do if your children start peeing cloudy urine.

What is Cloudy Urine?

Urine can become cloudy, hazy, or foggy if there are other substances in the urine. Cloudy urine is also referred to as turbid urine and can indicate a number of underlying factors.

According to doctors from the Mayo Clinic, the normal color of urine should be a pale yellow, almost translucent color, to deep amber. The reason for the difference in color of normal, healthy urine, is due to the concentration of a pigment called urochrome. The more urochrome is diluted then the lighter yellow color your urine will be.1

There are a number of factors that can turn your urine a different color. For example, researchers from UC San Diego Health say that some simple explanations for darker colored urine are dehydration, eating beets, rhubarb, or asparagus, consuming foods containing dyes, or taking certain medications.2

Milky cloudy urine could indicate the presence of certain proteins or white bl...

21:58

These results signifies the excellent antioxidant and anti-hyperlipidemic properties of C. asiatica leaf extracts. "IndyWatch Feed Health"

PMID:  Front Pharmacol. 2016 ;7:400. Epub 2016 Oct 28. PMID: 27840607 Abstract Title:  andAntioxidant, Anti-hyperlipidemic Properties and Chemical Characterization of(L.) Extract. Abstract:  The study aimed to identify the phenolic compounds present in(L.) () extract and evaluate the respective antioxidant potential as well as its cholesterol-lowering effects in the experimental animal model. Herein, the antioxidant potential of extracts was assessed by its free radical scavenging activity such as 2, 2-diphenyl -1- picrylhydrazyl as well as reducing capability. The anti-hyperlipidemic effects ofextract (CAE) were evaluated in high cholesterol-fed (HCF) rats for 4 weeks, where different concentrations of extracts (0.25, 0.5, and 1 g/kg/day) were orally administrated daily. Lipid and antioxidant profiles, including total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) and superoxide dismutase (SOD), together with the indices of hepatic functions were also examined.revealed excellent free radical scavenging activity as revealed by 2-2- diphenyl-1-picryl-hydrazyl (DPPH) assay, with the ICvalues (9.62 0.88 g/mL). Furthermore,extracts and fenofibrate remarkably lowered the level of TC, TG, LDL-C, and showed elevated levels of HDL-C, SOD. The histopathological observations further demonstrated clear differentiation and structural changes in liver of HCF and CAE treated group. Furthermore, gulonic acid, ferulic acid, kaempferol, chlorogenic acid, and asiatic acid were identified to be the major components which might be responsible for the antioxidant activity of theextract as evidenced from an ultra-high performance liquid chromatography-mass spectrometer. Taken together, these results signifies the excellent antioxidant and anti-hyperlipidemic properties ofleaf extracts, which might be useful for the treatment of oxidative-stress related diseases such as hyperlipidemia.

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21:51

5G Technology is Coming Linked to Cancer, Heart Disease, Diabetes, Alzheimers, and Death "IndyWatch Feed Health"

Transmission tower on landscape with 5g wireless signal waves. Cell phone brain damage

by John P. Thomas
Health Impact News

The new fifth generation (5G) cellular system that is being installed in major American cities such as Dallas, Atlanta, Waco, Texas, and Sacramento [1, 3] will intensify the microwave radiation health risks for everyone living in those cities. [2]

Eleven More Cities Targeted for 5G Deployment this Year

5G network wireless systems and internet of things , Smart city and communication network concept .

The new 5G cell systems that Verizon and AT&T are planning to install in other cities in 2018 [1, 3] will use shorter length microwaves than the existing 4G (fourth generation) systems. New generation cell phones will be able to communicate with either 5G or 4G microwave towers to optimize connectivity.

Copper phone lines will be replaced with 5G rooftop antennas on homes and businesses. These antennas will communicate with 5G cell towers and with the wireless equipment in homes and offices to provide phone and broadband services.

5G will be the foundation for the smart cities of the future. [15]

The Safety of 5G Has Not Been Tested

The microwave frequencies that are being used in this new generation 5G system are in the 1-millimeter wave length.

The long-term health risks of these short microwaves have not been adequately tested and the Federal Communications Commission (FCC) and telecom companies are simply presuming that they are safe based on 1996 research. [2, 16]

New Research Reveals Harmful Effects of Cellular Systems

Research on microwave frequency radiation conducted since 1996 shows that the existing 3G and 4G cellular systems are causing serious harm to human health.

The 5G systems will increase the level of...

21:47

Asiatic acid could be used as an effective chemopreventive agent against 1,2-dimethylhydrazine-induced colon carcinogenesis. "IndyWatch Feed Health"

PMID:  Toxicol Mech Methods. 2017 Feb ;27(2):136-150. Epub 2017 Jan 11. PMID: 28004603 Abstract Title:  Asiatic acid attenuates pre-neoplastic lesions, oxidative stress, biotransforming enzymes and histopathological alterations in 1,2-dimethylhydrazine-induced experimental rat colon carcinogenesis. Abstract:  Asiatic acid (AA), a pentacyclic triterpenoid, derived from the tropical medicinal plant Centella asiatica is known to exhibit numerous pharmacological properties. We hypothesized that AA will have chemopreventive potential against 1,2-dimethylhydrazine (DMH)-induced experimental colon carcinogenesis in male Wistar rats. Rats were arbitrarily divided into six groups. Group I rats were processed as control. Group II rats received AA (8mg/kg b.w., p.o.) and groups III-VI rats received subcutaneous injections of DMH (20mg/kg b.w.) once a week, for the first four weeks. In addition, groups IV-VI rats received AA at the doses of 2, 4 and 8mg/kg b.w., respectively, for 16 weeks. Our results discovered that supplementation with AA to the DMH-exposed rats significantly decreased the incidence of polyps and Aberrant crypt foci (ACF) as compared to the DMH-alone-exposed rats. Moreover, in the AA-supplemented DMH-exposed rats, we ascertained increased activities of the antioxidants and decreased levels of lipid peroxidation(LPO) in the liver and circulation and enhanced levels of both LPO and antioxidants in the colon, which were altered in the DMH-alone-exposed rats. Furthermore, we also observed altered activities of vitamins C and E and biotransforming enzymes in DMH-alone-exposed rats, which were reversed on AA supplementation. All the observations were supported by our histological findings. Thus, we can conclude that, AA could be used as an effective chemopreventive agent against DMH-induced colon carcinogenesis.

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21:38

50-Year Study Proves Spanking Children Is Just as Bad as Physical Abuse "IndyWatch Feed Health"

I would never discipline my kids by hitting them, but I have no problem with spanking. Have you ever heard or maybe even used that logic? Parents, caregivers, and scientists alike have always debated whether it is right or wrong to use spanking as discipline. If Shakespeares Prince Hamlet could hear the news today, he... View Article

The post 50-Year Study Proves Spanking Children Is Just as Bad as Physical Abuse appeared first on Healthy Holistic Living.

21:31

Asiatic acid inhibits lung cancer cell growth. "IndyWatch Feed Health"

PMID:  Acta Pharm Sin B. 2017 Jan ;7(1):65-72. Epub 2016 Jun 20. PMID: 28119810 Abstract Title:  Asiatic acid inhibits lung cancer cell growthandby destroying mitochondria. Abstract:  Asiatic acid (AA), a pentacyclic triterpene found in, displays significant anti-proliferative effects on cancer cellsalthough the underlying mechanism of this effect remains unknown. This study investigated the efficacy and mechanism of action of AA against lung cancer bothand. Using the MTT assay, AA was found to induce apoptosis in a dose- and time-dependent manner, an effect enhanced by pretreatment with an autophagy inhibitor. It also elevated expression of microtubule-associated protein 1 light chain 3 (LC3) and decreased the expression of p62. Furthermore, exposure to AA resulted in collapse of the mitochondrial membrane potential and generation of reactive oxygen species (ROS), suggesting mitochondria are the target of AA. In the mouse lung cancer xenograft model, oral administration of AA significantly inhibited tumor volume and weight accompanied by significant apoptosis of lung cancer cells. In addition, it led to a significant decrease in the expression of proliferating cell nuclear antigen (PCNA). In summary, the results show that AA significantly reduces lung cancer cell growth bothandand that the associated apoptosis is mediated through mitochondrial damage.

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21:27

30+ Phrases To Calm An Anxious Child "IndyWatch Feed Health"

Often people dont realize how much stress children can experience and how much pressure they can be under. Sometimes this pressure is put on themselves when they compare themselves to others, or sometimes they feel this pressure coming from parents or other family members. But one thing that is for sure is that childhood anxiety... View Article

The post 30+ Phrases To Calm An Anxious Child appeared first on Healthy Holistic Living.

21:24

Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2017 Apr ;88:252-259. Epub 2017 Jan 19. PMID: 28110191 Abstract Title:  Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation. Abstract:  Asiatic acid (AA), a natural triterpene isolated from the plant Centella asiatica, have antioxidative potential, but the molecular mechanism of AA against oxidative stress remains unclear. Our study was performed to investigate the antioxidative effect of AA against oxidative stress and the antioxidative mechanism in tert-butyl hydroperoxide (t-BHP) -stimulated the HepG2 cells. The results showed that AA suppressed t-BHP-induced cytotoxicity, apoptosis, and reactive oxygen species (ROS) generation. Additionally, AA activated the nuclear factor erythroid 2-related factor 2 (Nrf2) signal, which was closely related to induction Nrf2 nuclear translocation, reduction the expression of Keap1 and up-regulation the activity of the antioxidant response element (ARE). Meanwhile, activation of Nrf2 signal upregulated the protein expressions of antioxidant genes, including heme oxygenase-1 (HO-1), NAD(P)H: quinone oxidase (NQO-1), and glutamyl cysteine ligase catalytic subunit (GCLC). Excitingly, Knockout of Nrf2 almost abolished AA-mediated antioxidant activity and cytoprotection against t-BHP. Further studies showed the mechanism underlying that AA induced Nrf2 activation in HepG2 cells via Akt and ERK signal activation. We found Akt and ERK inhibitors treatment attenuated AA-mediated Nrf2 nuclear translocation. Furthermore, treatment with either Akt or ERK inhibitor also decreased AA-mediated cytoprotection against t-BHP-induced cellular damage. Collectively, these results presented in this study indicate that AA has the protective effect against t-BHP-induced cellular damage and oxidative stress by modulating Nrf2 signaling through activating the signals of Akt and ERK.

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21:14

Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2017 May ;89:1297-1309. Epub 2017 Mar 17. PMID: 28320097 Abstract Title:  Asiatic acid ameliorates pulmonary fibrosis induced by bleomycin (BLM) via suppressing pro-fibrotic and inflammatory signaling pathways. Abstract:  Idiopathic pulmonary fibrosis is known as a life-threatening disease with high mortality and limited therapeutic strategies. In addition, the molecular mechanism by which pulmonary fibrosis developed is not fully understood. Asiatic acid (AA) is a triterpenoid, isolated from Centella asiatica, exhibiting efficient anti-inflammatory and anti-oxidative activities. In our study, we attempted to explore the effect of Asiatic acid on bleomycin (BLM)-induced pulmonary fibrosis in mice. The findings indicated that pre-treatment with Asiatic acid inhibited BLM-induced lung injury and fibrosis progression in mice. Further, Asiatic acid down-regulates inflammatory cells infiltration in bronchoalveolar lavage fluid (BALF) and pro-inflammatory cytokines expression in lung tissue specimens induced by BLM. Also, Asiatic acid apparently suppressed transforming growth factor-beta 1 (TGF-1) expression in tissues of lung, accompanied with Collagen I, Collagen III, -SMA and matrix metalloproteinase (TIMP)-1 decreasing, as well as Smads and ERK1/2 inactivation. Of note, Asiatic acid reduces NOD-like receptor, pyrin domain containing-3 (NLRP3) inflammasome. The findings indicated that Asiatic acid might be an effective candidate for pulmonary fibrosis and inflammation treatment.

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20:52

European Commission Clears Bayers Acquisition of Monsanto With Conditions "IndyWatch Feed Health"

European Commission Clears Bayers Acquisition Monsanto With Conditions

The European Commission has approved under the EU Merger Regulation the acquisition of Monsanto by Bayer. The merger is conditional on the divestiture of an extensive remedy package, which addresses the parties overlaps in seeds, pesticides and digital agriculture.

Commissioner Margrethe Vestager, in charge of competition policy, said:

We have approved Bayers plans to take over Monsanto because the parties remedies, worth well over 6 billion, meet our competition concerns in full. Our decision ensures that there will be effective competition and innovation in seeds, pesticides and digital agriculture markets also after this merger.

In particular, we have made sure that the number of global players actively competing in these markets stays the same. 

That is important because we need competition to ensure farmers have a choice of different seed varieties and pesticides at affordable prices. And we need competition to push companies to innovate in digital agriculture and to continue to develop new products that meet the high regulatory standards in Europe, to the benefit of all Europeans and the environment.

Todays decision follows an in-depth review of Bayers proposed acquisition of Monsanto. Monsanto is the worlds largest supplier of seeds, which generates most of its sales in the US and Latin Americ...

20:51

Centella asiatica attenuates A-induced neurodegenerative spine loss and dendritic simplification. "IndyWatch Feed Health"

PMID:  Neurosci Lett. 2017 Apr 12 ;646:24-29. Epub 2017 Mar 6. PMID: 28279707 Abstract Title:  Centella asiatica attenuates A-induced neurodegenerative spine loss and dendritic simplification. Abstract:  The medicinal plant Centella asiatica has long been used to improve memory and cognitive function. We have previously shown that a water extract from the plant (CAW) is neuroprotective against the deleterious cognitive effects of amyloid- (A) exposure in a mouse model of Alzheimer's disease, and improves learning and memory in healthy aged mice as well. This study explores the physiological underpinnings of those effects by examining how CAW, as well as chemical compounds found within the extract, modulate synaptic health in A-exposed neurons. Hippocampal neurons from amyloid precursor protein over-expressing Tg2576 mice and their wild-type (WT) littermates were used to investigate the effect of CAW and various compounds found within the extract on A-induced dendritic simplification and synaptic loss. CAW enhanced arborization and spine densities in WT neurons and prevented the diminished outgrowth of dendrites and loss of spines caused by A exposure in Tg2576 neurons. Triterpene compounds present in CAW were found to similarly improve arborization although they did not affect spine density. In contrast caffeoylquinic acid (CQA) compounds from CAW were able to modulate both of these endpoints, although there was specificity as to which CQAs mediated which effect. These data suggest that CAW, and several of the compounds found therein, can improve dendritic arborization and synaptic differentiation in thecontext of A exposure which may underlie the cognitive improvement observed in response to the extract in vivo. Additionally, since CAW, and its constituent compounds, also improved these endpoints in WT neurons, these results may point to a broader therapeutic utility of the extract beyond Alzheimer's disease.

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20:05

What Are We Breathing? "IndyWatch Feed Health"

12By Catherine J. Frompovich

Does it seem as if its getting a little harder to breathe? You may not be mistaken. That may not be just a figment of your imagination, especially with all the varied and unsuspected sources of air pollution resulting especially from the proliferation of chemical companies tripping over themselves to introduce new scents.

Perfumes from natural sources have been around since time immemorial. A perfume maker was discovered on a 1200 BCE Cuneiform tablet in Babylonian Mesopotamia. [Wikipedia]

Perfumery existed in the ancient Indus civilization (3300 BCE 1300 BCE), while Ayurveda texts contain many references to herbs and other botanicals used for healing. [Wikipedia]

Moving into the modern era, Europe started to become involved with perfumery around the 14th century. France became the center of European scent and perfumes with the region around Grasse becoming the premiere center, now recognized as the world capital of perfume. [Wikipedia]

...

20:03

Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats. "IndyWatch Feed Health"

n/a PMID:  Pharm Biol. 2017 Dec ;55(1):1671-1678. PMID: 28447512 Abstract Title:  Centella asiatica enhances hepatic antioxidant status and regulates hepatic inflammatory cytokines in type 2 diabetic rats. Abstract:  CONTEXT: Neutralizing the over-activation of oxidative stress and inflammation remains an important goal in the management of type 2 diabetes mellitus (T2DM). Centella asiatica (L.) Urban (Apiaceae) (CA) has been used in traditional folklore in Africa and Asia to treat various ailments including diabetes. OBJECTIVE: We investigated the hepatic antioxidant and anti-inflammatory potential of methanol extract of CA leaves in T2DM. MATERIALS AND METHODS: T2DM was induced in male Sprague-Dawley rats with 10% fructose in drinking water for 14days followed by a single intraperitoneal injection of streptozotocin (40mg/kg b.wt). Hepatic oxidant/antioxidant status was assessed by measuring the concentrations of malondialdehyde (MDA), ferric reducing antioxidant power (FRAP), oxygen radical absorbance capacity (ORAC), Trolox equivalentantioxidant capacity (TEAC), reduced glutathione (GSH) and activities of glutathione S-transferase (GST) and glutathione peroxidase (GPX). The concentrations of cytokines IL-1, IL-4, IL-6, IL-10, MCP-1 and TNF- in the liver were determined. RESULTS: Diabetes increased MDA formed (47%) and reduced FRAP (20%), TEAC (15%), GSH levels (32%), significantly; decreased GST and GPX activities in the liver and elevated levels of cytokines studied. Treatment of diabetic rats with 500mg/kg b.wt CA for 14days decreased MDA (44%); elevated FRAP (15%) and GSH (131%) levels and increased the activities of GST and GPX by 16%. Hepatic concentrations of IL-1, MCP-1 and TNF- in DCA group were reduced to 68%, 75% and 63% of DC values, respectively. CONCLUSIONS: The antioxidant and anti-inflammatory properties of CA may protect tissues such as the liver from diabetes-induced oxidative damage.

19:55

Asiatic acid can prevent the spatial working memory and hippocampal neurogenesis impairments caused by 5-FU chemotherapy. "IndyWatch Feed Health"

PMID:  PLoS One. 2017 ;12(7):e0180650. Epub 2017 Jul 10. PMID: 28700628 Abstract Title:  Asiatic acid protects against cognitive deficits and reductions in cell proliferation and survival in the rat hippocampus caused by 5-fluorouracil chemotherapy. Abstract:  The chemotherapy drug, 5-fluorouracil (5-FU), has been reported to cause cognitive impairments in cancer patients. The drug also reduces cell proliferation and survival in the brain. Asiatic acid (AA) is a triterpene compound found in Centella asiatica that can protect against reduction of neurogenesis in the hippocampus and memory deficits induced by valproic acid (VPA). In the present study, we investigated the preventive effects of AA on the deficits in spatial working memory and cell proliferation and survival caused by 5-FU chemotherapy in a rat model. Male Sprague Dawley rats received 5-FU (5 i.v. injections, 25 mg/kg) on day 8, 11, 14, 17 and 20 of the study. This was co-administered with AA (30 mg/kg, oral gavage tube) either 20 days before receiving 5-FU (preventive), after receiving 5-FU (recovery), or for the entire period of the experiment (throughout). Spatial working memory was determined using the novel object location (NOL) test and hippocampal cell proliferation and survival of dividing cells were quantified using immunohistochemistry. Rats in the 5-FU alone and recovery groups showed memory deficits in the NOL test and reductions in cell proliferation and cell survival in the subgranular zone (SGZ) of the hippocampal dentate gyrus. Rats in the control, AA alone, and both preventive and throughout co-administration groups, however, did not exhibit these characteristics. The results showed that 5-FU chemotherapy impaired memory and reduced cell proliferation and cell survival in the SGZ of the hippocampal dentate gyrus. However, these impairments in the animals receiving 5-FU chemotherapy were restored to control levels when AA was co-administered before and during 5-FU treatment. These data demonstrate that AA can prevent the spatial working memory and hippocampal neurogenesis impairments caused by 5-FU chemotherapy.

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19:16

Centella asiatica attenuates mitochondrial dysfunction and oxidative stress in A-exposed hippocampal neurons. "IndyWatch Feed Health"

PMID:  Oxid Med Cell Longev. 2017 ;2017:7023091. Epub 2017 Aug 13. PMID: 28883904 Abstract Title:  Attenuates Mitochondrial Dysfunction and Oxidative Stress in A-Exposed Hippocampal Neurons. Abstract:  has been used for centuries to enhance memory. We have previously shown that a water extract of(CAW) protects against the deleterious effects of amyloid-(A) in neuroblastoma cells and attenuates A-induced cognitive deficits in mice. Yet, the neuroprotective mechanism of CAW has yet to be thoroughly explored in neurons from these animals. This study investigates the effects of CAW on neuronal metabolism and oxidative stress in isolated A-expressing neurons. Hippocampal neurons from amyloid precursor protein overexpressing Tg2576 mice and wild-type (WT) littermates were treated with CAW. In both genotypes, CAW increased the expression of antioxidant response genes which attenuated the A-induced elevations in reactive oxygen species (ROS) and lipid peroxidation in Tg2576 neurons. CAW also improved mitochondrial function in both genotypes and increased the expression of electron transport chain enzymes and mitochondrial labeling, suggesting an increase in mitochondrial content. These data show that CAW protects against mitochondrial dysfunction and oxidative stress in A-exposed hippocampal neurons which could contribute to the beneficial effects of the extract observed in vivo. Since CAW also improved mitochondrial function in the absence of A, these results suggest a broader utility for other conditions where neuronal mitochondrial dysfunction occurs.

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19:01

Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. "IndyWatch Feed Health"

PMID:  Front Biosci (Schol Ed). 2018 01 1 ;10:262-275. Epub 2018 Jan 1. PMID: 28930532 Abstract Title:  Neuroprotective role of Asiatic acid in aluminium chloride induced rat model of Alzheimer's disease. Abstract:  Alzheimer's disease (AD) is the most common form of dementia, characterized by memory loss, cognitive impairment and personality disorders accompanied by diffuse structural abnormalities in the brain of elderly people. The current investigation explored the neuroprotective potential of asiatic acid (AA), a natural triterpene ofon aluminium chloride (AlCl) induced rat model of AD. Oral administration of AlCl(100 mg/kg b.w.) for 42 days significantly elevated the levels of Al, activity of acetyl cholinesterase and expressions of amyloid precursor protein, amyloid beta, beta and gamma secretases, glial fibrillary acidic protein, ionized calcium binding adaptor molecule 1, interleukins -1, 6, 4, 2, tumor necrosis factor alpha, inducible nitric oxide synthase, nuclear factor- k beta and cyclooxygenase-2 in the hippocampus and cortex  compared to the control group. Our observations suggested that AA treatment mitigated AlClinduced AD associated pathologies, which might be due to its multiple pharmacological actions. Further studies are necessary in order to explore the link between AlCl-mediated oxidative stress and associated apoptosis to establish its neuroprotective role in AD.

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18:48

These findings suggest that asiatic acid prevents LPS-induced neuroinflammation. "IndyWatch Feed Health"

PMID:  Food Funct. 2018 Feb 21 ;9(2):1048-1057. PMID: 29354820 Abstract Title:  Asiatic acid suppresses neuroinflammation in BV2 microglia via modulation of the Sirt1/NF-B signaling pathway. Abstract:  Asiatic acid, a triterpenoid derived from Centella asiatica, has been found to exhibit multiple bioactivities. In this study, we investigated the effects of asiatic acid on lipopolysaccharide (LPS)-induced neuroinflammation and explored the mechanism of its action in BV2 microglia. We found that asiatic acid (0.1 to 100M) treatment significantly attenuated nitric oxide (NO) production and inhibited inducible nitric oxide synthase (iNOS) expression in a concentration-dependent manner following LPS exposure. Asiatic acid reduced LPS-induced expression and secretion of inflammatory cytokines, including tumor necrosis factor- (TNF-), interleukin-1 (IL-1) and interleukin-6 (IL-6) in BV2 cells. In addition, asiatic acid enhanced Sirt1 expression, reduced NF-B p65 acetylation, and suppressed NF-B activation after LPS stimulation. However, EX-527, an inhibitor of Sirt1, abolished the inhibitory effectsof asiatic acid on LPS-stimulated microglia activation. These findings suggest that asiatic acid prevents LPS-induced neuroinflammation via regulating the Sirt1/NF-B signaling pathway.

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18:30

Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells. "IndyWatch Feed Health"

PMID:  Microb Pathog. 2018 Mar ;116:195-199. Epub 2018 Jan 31. PMID: 29369796 Abstract Title:  Asiatic acid inhibits LPS-induced inflammatory response in endometrial epithelial cells. Abstract:  Accumulating evidence indicates that asiatic acid, a natural triterpene isolated from Centella asiatica, has anti-inflammatory activity. However, the anti-inflammatory effects of asiatic acid on LPS-stimulated endometrial epithelial cells and the involved molecular pathways have not been completely elucidated. In the present study, we evaluated the effects of asiatic acid on LPS-induced inflammatory response in endometrial epithelial cells. Mouse endometrial epithelial cells were treated with asiatic acid and stimulated with LPS. ELISA was performed to measure the levels of inflammatory cytokines TNF-, IL-1, and PGE. Western blot analysis was used to test the expression of PPAR and NF-B. The results showed that LPS-induced inflammatory mediators TNF-, IL-1, NO, and PGEwere significantly inhibited by asiatic acid. Furthermore, LPS-induced TLR4 expression and NF-B activation were concentration-dependently suppressed by asiatic acid. In addition, asiatic acid was found to increase the expression of PPAR in a concentration-dependently manner. The inhibition of asiatic acid on inflammatory mediators production were prevented by PPAR inhibitor, GW9662. Taken together, these results showed that asiatic acid exhibited its anti-inflammatory effects in endometrial epithelial cells by activating PPAR.

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17:55

Centella asiatica can be useful in the management of diabetic complications. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2018 Mar 1 ;101:447-457. Epub 2018 Mar 1. PMID: 29501767 Abstract Title:  Centella asiatica ameliorates diabetes-induced stress in rat tissues via influences on antioxidants and inflammatory cytokines. Abstract:  Centella asiatica (L.) Urban (Family: Apiaceae) is a perennial herb that has been used to elevate mood, improve memory, treat wounds and manage kidney-related ailments in African traditional medicine practice. This study evaluated the potential benefits of C. asiatica (CA) on diabetes-induced stress in kidney and brain of rats. Following the induction of diabetes mellitus (DM), rats were orally treated with vehicle, CA or Metformin daily for 14 days. After treatment, renal and brain levels of inflammatory cytokines, TNF-, IFN-, IL-4, and IL-10 were assessed. Oxidant and antioxidant biomarkers were also evaluated. Phyto-compounds in the crude methanol extract of CA were analyzed by Gas Chromatography-Mass Spectroscopy. Diabetes increased malondialdehyde (MDA) concentration by 39%; elevated levels of TNF- (44%)and IFN- (20%); and reduced the antioxidant status in the kidney in comparison to normal control rats. In the brain, diabetic control rats had significantly greater levels of MDA, TNF-, and IFN- (182%, 40%, and 20%, respectively) in addition to the lowered antioxidant status when compared tonormal control rats. However, treatment with CA significantly reduced the renal levels of MDA (33%), TNF- (78%), and IFN- (42%) while that of IL-10 increased by 18% when compared to diabetic control rats. In the brain, CA treatment elicited significant reductions in MDA (37%), TNF- (30%), andIFN- (37%) levels while those of IL-4 and IL-10 increased by 94% and 20% respectively. In addition, the renal and brain antioxidant status was significantly boosted by CA treatment. Several medicinal compounds including ascorbic acid, asiatic acid, oleanolic acid, stevioside, stigmasterol, and -humulene were identified in the crude extract of CA. Findings from this study suggest CA may protect diabetic tissues from stress via antioxidant and anti-inflammatory mechanisms that can be useful in the management of diabetic complications.

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17:43

There is another way Man Refuses Surgery and Chemo and Cures His Bladder Cancer With These "IndyWatch Feed Health"

cureyourowncancer org 2

Trevor Smith was diagnosed with bladder cancer and refused conventional treatments relying on natural methods to heal. (CureYourOwnCancer org)

 

trev

17:24

Treatment with ascorbic acid and -tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain. "IndyWatch Feed Health"

PMID:  Braz J Med Biol Res. 2018 Mar 1 ;51(4):e7097. Epub 2018 Mar 1. PMID: 29513797 Abstract Title:  Treatment with ascorbic acid and-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain. Abstract:  Vitamin E (vit. E) and vitamin C (vit. C) are antioxidants that inhibit nociception. The effect of these vitamins on oxidative-stress markers in the spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve is unknown. This study investigated the effect of intraperitoneal administration of vit. E (15 mgkg-1day-1) and vit. C (30 mgkg-1day-1), given alone or in combination, on spinal cord oxidative-stress markers in CCI rats. Adult male Wistar rats weighing 200-250 g were divided equally into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve), which received injections of vitamins or vehicle (saline containing 1% Tween 80) for 3 or 10 days (n=6/each group). The vitamins preventedthe reduction in total thiol content and the increase in superoxide-anion generation that were found in vehicle-treated CCI rats. While nitric-oxide metabolites increased in vehicle-treated CCI rats 3 days after surgery, these metabolites did not show significant changes in vitamin-treated CCI rats. In all rats, total antioxidant capacity and hydrogen-peroxide levels did not change significantly. Lipid hydroperoxides increased 25% only in vehicle-treated CCI rats. These changes may contribute to vit. C- and vit. E-induced antinociception, because scavenging reactive oxygen species seems to help normalize the spinal cord oxidative status altered by pain.

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17:07

Psychiatry and a Near Mass Shooting at Cornell "IndyWatch Feed Health"

Many people struggle to control their violent feelings. Almost none massacre other people. Psychiatric drugs can become the tipping point.

17:05

Another Large Study Links Cancer To Vitamin D Levels "IndyWatch Feed Health"

By Joe Battaglia

There are now thousands of references in medical literature that show vitamin Ds effectivenessboth for the prevention and treatment of cancer. Another large study shows that Vitamin D levels could have a direct influence in your risk of developing cancer, according to the results of a Japanese cohort study.

People with higher blood levels of vitamin D live significantly longer than people who have low blood levels of the vitamin.

Almost every disease decreases in frequency and duration as we move towards equatorial populations, and the data shows that there is a minimum of a 1000 percent increase for many diseases in countries furthest from the equator, however we have obtained the same results based on data through populations and vitamin D supplementation, said Dr. Anthony Petaku who studies the effects of Vitamin D2 a...

16:56

Fasting Reduces Cardiovascular Risk "IndyWatch Feed Health"

By Natasha Longo

Intermittent energy restriction diets such as the 5:2 diet clears fat from the blood quicker after eating meals compared with daily calorie restriction diets, reducing an important risk factor for cardiovascular disease, a new study in the British Journal of Nutrition reports.

Intermittent fasting allows the body to use fat as its primary source of energy instead of sugar and there are five huge benefits.

In the first study of its kind, researchers from the University of Surrey examined the impact of the 5:2 diet on the bodys ability to metabolise and clear fat and glucose after a meal and compared it to the effects of weight-loss achieved via a more conventional daily calorie restriction diet. Previous studies in this field have predominantly focused on blood risk markers taken in the fasted state, which only tend to be, in for the minority of the time, overnight.

16:54

Dietary intake of vitamin A and C showed a beneficial association with open-angle glaucoma. "IndyWatch Feed Health"

PMID:  Nutrients. 2018 Mar 16 ;10(3). Epub 2018 Mar 16. PMID: 29547516 Abstract Title:  The Effect of Vitamins on Glaucoma: A Systematic Review and Meta-Analysis. Abstract:  BACKGROUND: The aim of is to determine the association of vitamins with glaucoma by performing a systematic review and meta-analyses.METHODS: Studies on the relation of vitamins and glaucoma published up to December 2017 were identified in the PubMed and Embase database. Data on vitamins (method of assessment), glaucoma (type and method of assessment), study characteristics and quality were recorded. In case of multiple studies for one nutrient a meta-analysis was performed.RESULTS: A total of 629 articles were identified of which 36 were included in the systematic review. The meta-analysis included five of them (940 open-angle glaucoma (OAG) cases and 123,697 controls in total) and resulted in an odds ratio [95% confidence interval] (OR [95% CI]) of 0.58 [0.37-0.91] for dietary vitamin A, though heterogeneity was high (I = 51%). After omitting studies that contributed significantly to the heterogeneity, the pooled OR [95% CI] was 0.45 [0.30-0.68] for dietary vitamin A on OAG (I = 0%). For vitamin B1, C and E no significant association with OAG was found (OR [95% CI]: 0.84 [0.47-1.51]; 0.68 [0.38-1.22]; 0.95 [0.75-1.19]; respectively). However, after addressing heterogeneity, vitamin C showed a protective effect as well. Especially, foods high in these vitamins (e.g., dark green vegetables) were protective for OAG.CONCLUSIONS: Dietary intake of vitamin A and C showed a beneficial association with OAG; however, findings on blood levels of vitamins do not show a clear relation with OAG.

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16:34

Ascorbic acid as DNase I inhibitor in prevention of male infertility. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2018 Mar 15. Epub 2018 Mar 15. PMID: 29551685 Abstract Title:  Ascorbic acid as DNase I inhibitor in prevention of male infertility. Abstract:  Apoptotic and/or ROS-induced DNA fragmentation in sperm cells may contribute to the development of male infertility. As the known dietary antioxidant, ascorbic acid prevents ROS production and protects sperm cells from DNA damage. Here, we found that ascorbic acid has the ability to inhibit DNase I, one of the main endonucleases involved in DNA fragmentation during apoptosis. Site Finder and Molecular docking defined the ascorbic acid interactions with the most important residues of DNase I, including H-donor interactions with Asp 168 and Asn 170, and H-acceptor interaction with Asn 170. As a furan derivative, ascorbic acid could be considered a pioneer of substrate-based DNase I inhibitors. The results indicate to another possible mechanism for prevention of male infertility by ascorbic acid.

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16:24

Vitamin B6 Was Banned But Could Make a Comeback With You "IndyWatch Feed Health"

Vitamin B6

BY 

Pyridoxamine (vitamin B6) was banned as a supplementbut you can help bring it back. Action Alert!

This is exactly what happened to pyridoxamineand with your help we can bring it back.

Pyridoxamine is one of three bioavailable forms of vitamin B6. It has many health benefitsand is essential to human life. It...

16:04

Pre-treatment of skin sites with vitamin C led to a reduction in the intensity, or even ablation, of the cutaneous allergic reaction to p-phenylenediamine. "IndyWatch Feed Health"

PMID:  Contact Dermatitis. 2016 Jun ;74(6):368-72. Epub 2016 Mar 29. PMID: 27027508 Abstract Title:  Influence of vitamin C on the elicitation of allergic contact dermatitis to p-phenylenediamine. Abstract:  BACKGROUND: Hair dyes represent one of the most important causes of allergic contact dermatitis resulting from the use of cosmetic products. The principal causative chemistry is associated with oxidation products of p-phenylenediamine (PPD) and closely related substances.OBJECTIVES: To examine whether prior application of the antioxidant vitamin C to the skin was able to reduce the cutaneous allergic response to PPD.METHODS: Twenty eight volunteers with a proven history of contact allergy to PPD were recruited. Each was tested with a range of PPD doses and PPD-containing hair dye on untreated skin and skin pretreated for 10 min with a vitamin C formulation.RESULTS: Pretreatment of skin sites with vitamin C led to a reduction in the intensity, or even ablation, of the cutaneous allergic reaction to PPD in75% of cases as compared with untreated skin.CONCLUSIONS: The results suggest that treatment of the skin adjacent to the hair-bearing area with antioxidant could form part of a strategy to reduce the burden of cosmetic allergic contact dermatitis caused by hair dyeing.

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16:00

Management researcher admits to falsification, resigns "IndyWatch Feed Health"

A business journal has retracted two papers after the corresponding author admitted he falsified his results. David DeGeest, an assistant professor in the Department of Management and Marketing, has also resigned from The Hong Kong Polytechnic University, a university spokesperson told Retraction Watch. Last month, DeGeest confessed to the Journal of Management (JOM) that he Continue reading Management researcher admits to falsification, resigns

16:00

A Mind is a Terrible Thing to Waste "IndyWatch Feed Health"

We need you to be part of our winning team.

So far, we have raised $26,654 from 174 donors for our lawsuit against the Environmental Protection Agency (EPA). Thank you so very much to everyone who has contributed.

We need to raise $75,000 by May 31st to be eligible for $150,000 in matching grants! All donations are tax-exempt as Fluoride Action Network is a project of the American Environmental Health Studies Project, Inc., a 501(c)(3) non-profit. All donations will go into a designated legal fund. See details below on how to make your donation.

A mind is a terrible thing to waste*

The following is from a review of our Citizens Petition under the Toxic Control Substances Act

Available evidence suggests that the following are all associated with IQ reductions:

  1. Daily fluoride doses
  2. Urine fluoride levels
  3. Serum fluoride levels, and
  4. Dental fluorosis levels

.
The 2017 US government-funded Bashash study certainly highlighted the importance of urine fluoride levels. Note this study followed 300 mother-child pairs and found that urine fluoride levels in the mothers corresponding to fluoride levels experienced by adults in fluoridated communities in the USA-  was associated with a 6 IQ point loss in their offspring.

Each of these four metrics of fluoride exposure provide a more direct assessment of individual fluoride exposure than water fluoride concentration and are thus more probative for risk assessment purposes.

In the study by Wang et al. the authors found a clear dose response relationship between daily fluoride dose and reduced IQ. When this data was quantified using standard techniques Hirzy et al. (2016) it showed that a dose of 1.4 mg/day lowered IQ by 5 IQ points. While the precise extent to which fluoridation is reducing IQ in the U.S. cannot yet be calculated, the dose-response...

15:38

Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2018 01 1 ;495(1):433-437. Epub 2017 Nov 9. PMID: 29129689 Abstract Title:  Ascorbic acid attenuates endothelial permeability triggered by cell-free hemoglobin. Abstract:  BACKGROUND: Increased endothelial permeability is central to shock and organ dysfunction in sepsis but therapeutics targeted to known mediators of increased endothelial permeability have been unsuccessful in patient studies. We previously reported that cell-free hemoglobin (CFH) is elevated in the majority of patients with sepsis and is associated with organ dysfunction, poor clinical outcomes and elevated markers of oxidant injury. Others have shown that Vitamin C (ascorbate) may have endothelial protective effects in sepsis. In this study, we tested the hypothesis that high levels of CFH, as seen in the circulation of patients with sepsis, disrupt endothelial barrier integrity.METHODS: Human umbilical vein endothelial cells (HUVEC) were grown to confluence and treated with CFH with or without ascorbate. Monolayer permeability was measured by Electric Cell-substrate Impedance Sensing (ECIS) or transfer ofC-inulin. Viability was measured by trypan blue exclusion. Intracellular ascorbate was measured by HPLC.RESULTS: CFH increased permeability in a dose- and time-dependent manner with 1 mg/ml of CFH increasing inulin transfer by 50% without affecting cell viability. CFH (1 mg/ml) also caused a dramatic reduction in intracellular ascorbate in the same time frame (1.4 mM without CFH, 0.23 mM 18 h after 1 mg/ml CFH, p 

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15:27

Health Canada approves GM Golden Rice But It Wont Be Sold There "IndyWatch Feed Health"

Health Canada approves GM Golden Rice not intended for sale in Canada

Ottawa Health Canada has announced its approval of the genetically modified (GM or genetically engineered) Vitamin A enhanced Golden Rice even though it is not intended for sale in Canada and has not yet been approved by regulators in the intended markets.

Health Canada should not be spending public resources to assess the safety of GM foods that will not be sold in Canada, said Lucy Sharratt of the Canadian Biotechnology Action Network (CBAN).

Golden Rice is genetically engineered to have Vitamin A and is promoted as part of a solution to Vitamin A deficiency which is a serious public health problem in many developing countries, but not in Canada. Golden Rice is intended for distribution in the Philippines as well as other countries including Bangladesh, India and Indonesia where rice is a major staple food.

Farmers and consumers rights networks in the Philippines have expressed alarm about Canadas approval. The networks are concerned that a national policy loophole could enable proponents to use Canadas approval as a safety stamp to introduce Golden Rice in the Philippines and start feeding trials including with children and pregnant women.

SEE: First GM Rice Just...

15:14

Vitamin C enhances anticancer activity in methotrexatetreated Hep3B hepatocellular carcinoma cells. "IndyWatch Feed Health"

PMID:  Oncol Rep. 2014 Sep ;32(3):1057-63. Epub 2014 Jun 25. PMID: 24969544 Abstract Title:  Vitamin C enhances anticancer activity in methotrexatetreated Hep3B hepatocellular carcinoma cells. Abstract:  Methotrexate (MTX) has been widely used for rheumatoid arthritis therapy for a long time. MTX is also used as an anticancer drug for various tumors. However, many studies have shown that high-dose MTX treatment for cancer therapy may cause liver and renal damage. Alhough the mechanisms involved in MTX-induced liver and renal damage require further research, many studies have indicated that MTX-induced cytotoxicity is associated with increases in oxidative stress and caspase activation. In order to reduce MTX-induced side-effects and increase anticancer efficiency, currently, combination treatments of low-dose MTX and other anticancer drugs are considered and applied for various tumor treatments. The present study showed that MTX induces increases in H2O2 levels and caspase-9/-3 activation leading to cell death in hepatocellular carcinoma Hep3B cells. Importantly, this study is the first to demonstrate that vitamin C can efficiently aid low-dose MTX in inducing cell death in Hep3B cells. Therefore, the present study provides a possible powerful therapeutic method for tumors using a combined treatment of vitamin C and low-dose MTX.

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14:46

Reprograming of glucose metabolism by zerumbone suppresses hepatocarcinogenesis. "IndyWatch Feed Health"

PMID:  Mol Cancer Res. 2018 Feb ;16(2):256-268. Epub 2017 Nov 29. PMID: 29187559 Abstract Title:  Reprograming of Glucose Metabolism by Zerumbone Suppresses Hepatocarcinogenesis. Abstract:  Hepatocellular carcinoma (HCC) is the most prevalent and highly aggressive liver malignancy with limited therapeutic options. Here, the therapeutic potential of zerumbone, a sesquiterpene derived from the ginger plant, against HCC was explored. Zerumbone inhibited proliferation and clonogenic survival of HCC cells in a dose-dependent manner by arresting cells at the G-M phase and inducing apoptosis. To elucidate the underlying molecular mechanisms, a phosphokinase array was performed that showed significant inhibition of the PI3K/AKT/mTOR and STAT3 signaling pathways in zerumbone-treated HCC cells. Gene expression profiling using microarray and analysis of microarray data by Gene Set Enrichment Analysis (GSEA) and Ingenuity Pathway Analysis (IPA) revealed that zerumbone treatment resulted in significant deregulation of genes regulating apoptosis, cell cycle, and metabolism. Indeed, tracing glucose metabolic pathways by growing HCC cells withC-glucose and measuring extracellular and intracellular metabolites by 2D nuclear magnetic resonance (NMR) spectroscopy showed a reduction in glucose consumption and reduced lactate production, suggesting glycolytic inhibition. In addition, zerumbone impeded shunting of glucose-6-phosphate through the pentose phosphate pathway, thereby forcing tumor cells to undergo cell-cycle arrest and apoptosis. Importantly, zerumbone treatment suppressed subcutaneous and orthotopic growth and lung metastasis of HCC xenografts in immunocompromised mice. In conclusion, these findings reveal a novel and potentially effective therapeutic strategy for HCC using a natural product that targets cancer cell metabolism.Dietary compounds, like zerumbone, that impact cell cycle, apoptosis, and metabolic processes may have therapeutic benefits for HCC patients..

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13:58

Zerumbone can be a natural medicine to treat or prevent UVA-induced skin damage and photoaging. "IndyWatch Feed Health"

PMID:  Biochem Pharmacol. 2018 Feb ;148:130-146. Epub 2017 Dec 20. PMID: 29273513 Abstract Title:  Zerumbone protects human skin keratinocytes against UVA-irradiated damages through Nrf2 induction. Abstract:  Ultraviolet A (UVA) irradiation is toxic to skin as it penetrates deep into the dermis and damages cellular components through excessive reactive oxygen species (ROS) production, which accelerates photoaging and skin cancer. We evaluated the dermato-protective efficacies of zerumbone (natural sesquiterpene of Zingiber zerumbet) in UVA-irradiated human skin keratinocyte (HaCaT) cells and mouse epidermis. Zerumbone pretreatment (2-10M) substantially suppressed UVA (15J/cm)-induced HaCaT cell death and lactate dehydrogenase release in a dose-dependent manner. UVA-induced excessive ROS production, DNA single-strand breaks, apoptotic DNA fragmentation and a dysregulated Bax/Bcl-2 ratio were remarkably reversed by zerumbone in keratinocytes. Zerumbone-mediated cytoprotective properties were associated with increased nuclear translocation of nuclear factor-E2-related factor-2 (Nrf2) and elevated antioxidant response element (ARE) luciferase activity. Activation of Nrf2/ARE signaling was accompanied by induction of heme oxygenase-1 (HO-1) and-glutamyl cysteine ligase (-GCLC) genes in zerumbone-treated keratinocytes. Zerumbone-induced Nrf2 transcriptional activation was mediated by the p38 MAPK, PI3K/AKT and PKC signaling cascades. Notably, silencing of Nrf2 (siRNA transfection) significantly diminished zerumbone-mediated cytoprotective effects, as evidenced by impaired antioxidant genes, uncontrolled ROS/apoptotic DNA fragmentation and keratinocytes death, following UVA irradiation. In vivo evidence demonstrated that zerumbone treatment to nude mice (55 and 110g/day) significantly ameliorated UVA (15J/cm/every 2-day/14-day) cytotoxicity via increased nuclear localization of Nrf2 and Nrf2-dependent antioxidant genes (HO-1 and-GCLC) in UVA-treated skin tissues. Our findings emphasized the significance of Nrf2/ARE-signaling in zerumbone-mediated induction of antioxidant genes against UVA-toxicity. The molecular evidence suggests zerumbone can be a natural medicine to treat/prevent UVA-induced skin damage/photoaging.

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13:38

Zerumbone induces apoptosis, cell cycle arrest, and antimigratory effects in SW480 colorectal cancer cells. "IndyWatch Feed Health"

PMID:  J Agric Food Chem. 2018 Jan 24 ;66(3):602-612. Epub 2018 Jan 16. PMID: 29276946 Abstract Title:  Zerumbone, a Cyclic Sesquiterpene from Zingiber zerumbet Induces Apoptosis, Cell Cycle Arrest, and Antimigratory Effects in SW480 Colorectal Cancer Cells. Abstract:  Zerumbone isolated from the rhizomes of Zingiber zerumbet was investigated for the mechanisms by which it exhibits antiproliferative activity in colorectal cancer cells (SW480). The results indicated that the zerumbone suppressed cell growth and enhanced cell apoptosis. Exposure to zerumbone induced generation of reactive oxygen species, reduced the cellular antioxidant status, decreased mitochondrial membrane potential, and activated caspase 3, caspase 8, and caspase 9 (p

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13:18

Extending dental care to schools "IndyWatch Feed Health"

Four staff members of the dental ward in Samoa visited Fagalii Primary School on Monday.

This is part of their dental project which began in June last year. It is held every three months.

The visit focuses on teaching children ways of preventing tooth decay and the importance of maintaining healthy teeth.

Since June, 30 students with tooth decay in Year 1 were monitored up until they reached Year 6. These students were taught various methods of preventing tooth decay.

Students who received dental care classes have less chance of getting tooth decay. And we gave an award to one little girl because she didnt have any tooth decay in this project.  It helps to keep high motivations for children too, says Dental Hygienist and Project Coordinator, Chie Orita.

Ms. Orita is a dental surgeon from Japan and is in Samoa to help local surgeons use dental machines and provide treatment.

Through the support of the principal, we were able to visit this school, this being the fourth visit.

The project involves three main activities.

First we diagnose the childrens teeth and make a report for their parents about childrens teeth. If they need moderate tooth decay treatment, we provide saforide (drug used to prevent tooth decay) for them.

Four staff members of the dental ward in Samoa visited Fagalii Primary School on Monday.

This is part of their dental project which began in June last year. It is held every three months.

The visit focuses on teaching children ways of preventing tooth decay and the importance of maintaining healthy teeth.

Since June, 30 students with tooth decay in Year 1 were monitored up until they reached Year 6. These students were taught various methods of preventing tooth decay.

Students who received dental care classes have less chance of getting tooth decay. And we gave an award to one little girl because she didnt have any tooth decay in this project.  It helps to keep high motivations for children too, says Dental Hygienist and Project Coordinator, Chie Orita.

Ms. Orita is a dental surgeon from Japan and is in Samoa to help local surgeons use dental machines and provide treatment.

Through the support of the principal, we were able to visit this school, this being the fourth visit.

The project involves three main activities.

First we diagnose the childrens teeth and make a report for their parents about childrens teeth. If they need moderate tooth decay treatment, we provide saforide (drug used...

13:00

Caught Our Notice: Former rising star loses fourth paper "IndyWatch Feed Health"

Title: Haemophilus influenzae responds to glucocorticoids used in asthma therapy by modulation of biofilm formation and antibiotic resistance What Caught Our Attention: This is the fourth retraction for Robert Ryan, formerly a high-profile researcher studying infections that can be deadly in people with lung diseases such as cystic fibrosis. In 2016, the University of Dundee Continue reading Caught Our Notice: Former rising star loses fourth paper

12:45

Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages. "IndyWatch Feed Health"

PMID:  Int Immunopharmacol. 2018 Feb ;55:312-322. Epub 2018 Jan 5. PMID: 29310107 Abstract Title:  Zerumbone suppresses the activation of inflammatory mediators in LPS-stimulated U937 macrophages through MyD88-dependent NF-B/MAPK/PI3K-Akt signaling pathways. Abstract:  Zerumbone (ZER), isolated mainly from the Zingiber zerumbet (Z. zerumbet) rhizomes was found to be effective against numerous inflammatory and immune disorders, however, the molecular and biochemical mechanisms underlying its anti-inflammatory and immunosuppressive properties have not been well studied. This study was carried out to examine the profound effects of ZER on inflammatory mediated MyD88-dependent NF-B/MAPK/PI3K-Akt signaling pathways in LPS-stimulated U937 human macrophages. ZER significantly suppressed the up-regulation pro-inflammatory mediators, TNF-, IL-1, PGE, and COX-2 protein in LPS-induced human macrophages. Moreover, ZER significantly downregulated the phosphorylation of NF-B (p65), IB, and IKK/ as well as restored the degradation of IB. ZER correspondingly showed remarkable attenuation of the expression of Akt, JNK, ERK, and p38 MAPKs phosphorylation in a concentration-dependent manner. ZER also diminished the expression of upstream signaling molecules TLR4 and MyD88, which are prerequisite for the NF-B, MAPK and PI3K-Akt activation. Additionally, quantification of relative gene expression of TNF-, IL-1, and COX-2 indicated that, at a higher dose (50M), ZER significantly downregulated the elevated mRNA transcription levels of the stated pro-inflammatory markers in LPS-stimulated U937 macrophages. The strong suppressive effects of ZER on the activation of inflammatory markers in the macrophages via MyD88-dependent NF-B/MAPK/PI3K-Akt signaling pathways suggest that ZER can be a preventive and potent therapeutic candidate for the management of various inflammatory-mediated immune disorders.

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12:28

Manhattan Beach and Hermosa Beach support ban of hydrofluoric acid from Torrance refinery "IndyWatch Feed Health"

On Tuesday night, the Manhattan Beach City Council, in a unanimous vote, joined Hermosa Beach and Redondo Beach, as well as the county Board of Supervisors, to approve signing onto a letter to the Southcoast Air Quality Management District opposing the use of MHF at the Torrance Refinery.

All three beach cities want the hydrofluoric acid eliminated from the refinery. PBF Energy purchased the 155,000 barrel-per-day refinery from ExxonMobil following a February 2015 explosion that opponents believe could have potentially led to a catastrophic release of the acid.

The Manhattan Beach City Council said Tuesday they are viable alternatives that were already being instituted at other refineries. The risk of the deadly chemical spreading in an accident was just too great, they said.

There is a lot of risk that we all live with, some of it we are trying to mitigate, said Councilmember Nancy Hersman. There is only so much you can do. Were going to have earthquakes. But do we really need to risk that? I have to come down on the side of our community thats very concerned about it, and our residents are afraid its just too much risk.

Councilmember Steve Napolitano said he was not interested in shutting down the Torrance refinery as they contribute many jobs in the community. But nonetheless, he supported a ban on MHF.

What I do know is this is bad stuff and in the grand scheme of things we are trying to get rid of bad stuff, Napolitano said. Industry does find a way, but sometimes they need a push. I think the refinery will survive, but they do need a push to move away form MHF.

More than 30 people spoke at the Manhattan Beach meeting, many of whom worked at the Torrance refinery and supported the use of the dangerous chemical. Others from the Torrance Refinery Action Alliance were opposed to its use.

While it is dangerous, there are other dangerous things we work with, said one employee. It is dangerous, but they respect it. They dont fear it. A lot of the safety equipment is there to protect the workers and community.

Adam Web, a technical expert at the Torrance refinery, said there was lots of misinformation and speculation being spread about MHF.

There is risk and safety, he said. MHF was shown in the 90s to be as safe or safer than any alternative. Nothing else has been commercially proven.

Hermosa Beach support

At the March 13 Hermosa Beach City Council meeting, there were also more than 30 speakers with a majority in favor of the ban. The council voted 3-1 in favor of t...

11:58

Fasting Reduces Cardiovascular Risk "IndyWatch Feed Health"

Intermittent energy restriction diets such as the 5:2 diet clears fat from the blood quicker after eating meals compared with daily calorie restriction diets, reducing an important risk factor for cardiovascular disease, a new study in the British Journal of Nutrition reports.

11:03

The More Opioids Doctors Prescribe, the More Money They Make "IndyWatch Feed Health"

An exclusive analysis by CNN and researchers at Harvard University found that opioid manufacturers are paying physicians huge sums of money  and that doctors with higher prescription rates are paid larger amounts.

CNN spoke with two women whove struggled with opioid addiction, and they described the sense of betrayal they felt when they learned that their doctors had received large sums of money from the manufacturers of the drugs that had created such havoc in their lives.

Carey Ballou said she trusted her doctor and figured that if he was prescribing opioids, it must be because they were the best option for her pain.

Then she learned that opioid manufacturers paid her doctor more than a million dollars over two years.

Once I found out he was being paid, I thought, was it really in my best interest, or was it in his best interest? she said.

Article 

11:02

The Entire Archives of Radical Philosophy Go Online "IndyWatch Feed Health"

From Open Culture: The intellectual culture of the academic humanities has increasingly come under attack by those claiming that leftist academic work is solely focused on political correctness, identity politics, and thought policing. The journal Radical Philosophy challenges these critiques by presenting a much more nuanced, complex picture of academic work, publishing a wide range of perspectives on a variety of issues; the journals archive is now available online.

You can now read for free all of these essays and hundreds more at the Radical Philosophy archive, either on the site itself or in downloadable PDFs. The journal, run by an Editorial Collective, still appears three times a year. The most recent issue features an essay by Lars T. Lih on the Russian Revolution through the lens of Thomas Hobbes, a detailed historical account by Nathan Brown of the term postmodern, and its inapplicability to the present moment, and an essay by Jamila M.H. Mascat on the problem of Hegelian abstraction.

If nothing else, these essays and many others should upend facile notions of leftist academic philosophy as dominated by postmodern denials of truth, morality, freedom, and Enlightenment thought, as doctrinaire Stalinism, or little more than thought policing through dogmatic political correctness. For every argument in the pages of Radical Philosophy that might confirm certain readers biases, there are dozens more that will challenge their assumptions, bearing out Foucaults observation that philosophy cannot be an endless scrutiny of its own propositions.'

Article 

11:01

Knowledge of Other Cultures is Changing the Field of Psychology "IndyWatch Feed Health"

From The Conversation: Human behavior and mental processes have long been thought to be universal. However, recent studies show that culture plays an important role in shaping our cognitive styles, self-perception, and mental health.

If you were asked to describe yourself, what would you say? Would you describe yourself in terms of personal characteristics being intelligent or funny or would you use preferences, such as I love pizza? Or perhaps you would instead base it on social relationships, such as I am a parent? Social psychologists have long maintained that people are much more likely to describe themselves and others in terms of stable personal characteristics.

However, the way people describe themselves seems to be culturally bound. Individuals in the western world are indeed more likely to view themselves as free, autonomous and unique individuals, possessing a set of fixed characteristics. But in many other parts of the world, people describe themselves primarily as a part of different social relationships and strongly connected with others. This is more prevalent in Asia, Africa and Latin America. These differences are pervasive, and have been linked to differences in social relationships, motivation and upbringing.

Article 

10:00

The Concerned Parents Project March 21st "IndyWatch Feed Health"

What if your childs school difficulties have to do with poor eyesight or poor hearing? What if his or her lethargy, pain complaints, or sleeplessness are symptoms of a medical condition?

 

See if you can rule out genuine organic and biological causes for the symptoms that your child is displaying before supposing that they are symptoms of a mental disorder.

Unfortunately, the root causes of human behaviors are not so easily traced back to medical conditions even when such conditions exist. Equally unfortunately, the medical profession is under constant pressure from the pharmaceutical industry to shrink the normal range and increase the abnormal range of everything, paving the way for the prescription of chemicals. So, it may prove hard for doctors to accurately diagnosis a medical condition that actually exists and hard for them to restrain themselves from diagnosing conditions that do not truly exist.

Still, as possibly frustrating as the experience may prove, make sure that a medical workup is part of your plan to help your child with his or her current difficulties. And if that visit culminates in the doctor wanting to diagnose your child with a mental disorder, make sure to ask the following question: In the absence of hard science that suggests that feelings, attitudes and behaviors are medical problems, why are you treating this like a medical problem? See if the answer you get satisfies youor if you get any answer at all. A medical workup is a necessity, in case a genuine medical condition is present. But be alert to the ways in which such a visit can lead to a spurious, non-medical mental disorder diagnosis.

*****

Read the Concerned Parents Project Introductory Post

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06:00

Whats in That New Car Smell? "IndyWatch Feed Health"

By Dr. Mercola

Lets face it, many people love that new car smell. In fact, it is so intoxicating air fresheners for cars are designed to mimic the scent. Scientists arent sure why this particular scent holds so much appeal, but it is likely a form of classical conditioning, since the smell is associated with the luxury of owning a new car. Scent is a powerful marketing tool as it commonly evokes feelings and emotions on which sales people are adept at capitalizing.

Memories associated with certain scents is called odor-evoked autobiographical memory or the Proust phenomenon, named after French writer Marcel Proust. Researchers have discovered your brain analyzes odors and memories in a similar region, closely connected to your amygdala and hippocampus. This connection may explain why scent is tied to vivid memories.

Scents may not only bring up good memories but may also be associated with traumatic memories, triggering trauma-related flashbacks. The power of scent reveals why aromatherapy is so effective in generating calmness and relaxation. However, while the scent of a new car may generate good feelings related to the ownership of a new luxury toy, the scent carries significant health risks and car manufacturers do not purposely include it in new cars.

Off-Gassing Unregulated VOCs Create Some of the Scent in Your Car

Tests were done on 200 of the most popular cars in 2011-2012, checking for chemicals off-gassing from steering wheels, armrests, carpet and dashboards that contribute to the new car smell.1 The researchers were interested in measurements, as the average American spends 1.5 hours each day in their car, and off-gassing chemicals are a significant contributor to indoor air pollution.

The truth is, that new car smell is made up of volatile organic compounds (VOCs). Robert Weiz, certified microbial investigator and founder of RTK Environmental Group,2 says the materials used to make the interior of a new car contain plastics, glue and carpeting, all of which outgas or release VOC molecules.

Although these molecules eventually evaporate, contributing to outdoor air pollution, in a confined space they are immediately harmful to inhale. Some individuals experience abrupt symptoms such as headaches and respiratory problems.3 This class of chemicals is present in cleaning products, home improvement products and buil...

Difference Between Heart Attack and Cardiac Arrest "IndyWatch Feed Health"

By Dr. Mercola

According to the Centers for Disease Control and Prevention (CDC),1 approximately 610,000 people die of heart disease in the United States every year. Nearly 735,000 Americans have a heart attack each year. Of these, 525,000 are a first heart attack and 210,000 are repeat heart attacks. Knowing the risk factors, symptoms and taking early action increases the chances of survival.

There are a number of risk factors associated with heart attack. Data published in the Journal of the American College of Cardiology2 demonstrates that by following six lifestyle guidelines, women may lower their risk of heart disease by 92 percent and of heart attack by 70 percent. These include eating a healthy diet, getting 2.5 hours of exercise each week, not smoking and limiting alcohol, maintaining a normal weight and watching television no more than seven hours per week.

Stress,3 less than optimal mineral levels,4 daylight saving time5 and even severe emotional loss6 can increase your risk of heart attack as well. While many use the terms "heart attack" and "cardiac arrest" interchangeably, the two conditions are actually different, and knowing the difference can be a matter of life and death.

Heart Attack or Cardiac Arrest?

Sudden, unexpected cardiac arrest is the third leading cause of death in the U.S.,7 which is different from a heart attack. Understanding this difference can help save a life. The most immediately recognizable difference between the two conditions is that a heart attack victim will remain conscious with their heart beating, while someone who suffers from sudden cardiac arrest will be unconscious, with no discernible heartbeat.

Your heart is an extraordinary organ, even continuing to function when it's detached from your body....

What Is Prediabetes? "IndyWatch Feed Health"

By Dr. Mercola

Insulin is absolutely essential to staying alive; unfortunately, the vast majority of people have resistance to this essential hormone, speeding up the aging process and contributing to the development of degenerative diseases. Any meal high in grain and sugar carbs typically generates a rapid rise in blood glucose. To compensate, your pancreas secretes insulin into your bloodstream, which lowers your blood sugar to keep you from dying.

Insulin, however, is also very efficient at lowering blood sugar by turning it into fat. The more you secrete, the fatter you become. If you consistently consume a high-sugar, high-grain diet, your blood glucose level will be correspondingly high and over time your body becomes desensitized to insulin, requiring more and more of it to get the job done. Eventually, you become insulin resistant and prone to weight gain, and then full-blown diabetic.

Majority of Americans Are Likely Prediabetic

Prediabetes1 is defined as an elevation in blood glucose over 100 milligrams per deciliter (mg/dl) but lower than 125 mg/dl, at which point it formally becomes Type 2 diabetes. According to the U.S. Centers for Disease Control and Prevention, an estimated 84 million American adults about 1 in 3 are prediabetic, and most are unaware of this fact.

However, this is a semantic moot point as any fasting blood sugar regularly over 90 in my book suggests insulin resistance. As you will read below, the seminal work of the late Dr. Joseph Kraft, author of Diabetes Epidemic and You: Should Everyone Be Tested? suggests that 80 percent 8 out of 10 of Americans are insulin resistant.

Based on data from 14,000 patients,2 Kraft, former chairman of the department of clinical pathology and nuclear medicine at St. Josephs Hospital, Chicago, developed a powerful predictive test for diabetes.3 He would have the patient drink 75 grams of glucose and then measure their insulin response over time, at half-hour intervals for up to five hours.

Interestingly, he noticed five distinctive patterns suggesting a vast majority of people were already diabetic, even though their fasting glucose was normal. Only 20 percent of patients had a pattern signaling healthy post-prandial insulin sensitivity and low diabetes...

Video: The Persecution of Count Dankula "IndyWatch Feed Health"

Sarah Corriher discusses how tyranny has taken hold in Scotland, wherein Mark Meechan (Count Dankula) faces prison time for making a comical video.

You may watch this on YouTube if there are any problems watching the video at this site. It can also be viewed at Bit Chute.

02:12

World Mercury Project On Autoimmune Disease "IndyWatch Feed Health"

Note: Excerpted from World Mercury Project. Autoimmune diseases have become increasingly common in the United States and other high-income countries over the past several decades and now affect an estimated 5%-10% of the population in those countries. The broad category...

01:48

Steemit Group Raising Funds for Family Protection Who Are They? "IndyWatch Feed Health"

steemit-family-protection

The Steemit Family Protection group asks people to donate cryptocurrency earned on Steemit to their cause of Family Protection and claims to have already raised over $29,000.00 worth of cryptocurrency. But when we asked for more information about who runs this group, we were met with resistance.

by Brian Shilhavy
Editor, Health Impact News

The Fake News wars are raging in full force these days, as the corporate-sponsored mainstream media fights to hang on to its influence in American culture, using the term Fake News to refer to anyone outside of their influence who publishes material contrary to their own agendas.

They are exerting extreme pressure on social media giants such as Facebook and Google-owned YouTube, where the term Fake News is being used to censor content that they deem fake or false.

As a result, many are looking for alternative platforms to exchange the free-flow of information without centralized authoritarian censorship based on political views and ideology.

A new kind of social media platform that was started in 2016 is Steemit, which is based on blockchain technology, the same technology used for cryptocurrencies, like Bitcoin.

There are many advantages advertised for this new technology, and because it is community-driven, it is seen by many as an alternative to current social media networks that are controlled from the top down, which can lead to censorship based on the political views of those who control the platform.

But Steemits biggest advantage is seen in the ability of its users to earn rewards (cryptocurrency) for themselves for participating in the network. From Steemits FAQ:

What is Steemit.com?

Steemit has redefined social media by building a living, breathing, and growing social economy a community where users are rewarded for sharing their voice. Its a new kind of attention economy.

How does Steemit work?

...

01:20

Transcranial Magnetic Stimulation: What You Need to Know "IndyWatch Feed Health"

It's frustrating, isn't it? I mean not having a clue what intervention may work for your mood or anxiety disorder - if any. Hmmm. Well, I guess that means we have to be diligent in examining all options. Just now, let's take a look at transcranial magnetic stimulation. Please, tap-in...

01:09

Comprehensive Nutritional and Dietary Intervention for Autism Spectrum DisorderA Randomized, Controlled 12-Month Trial "IndyWatch Feed Health"

Note: Food has always been the starting point of health since "an apple a day," and all that. Many of us have found some relief from the symptoms of autism via dietary changes. Some have had life altering successes for...

00:44

Video: Fire/Cooking Supplies For Disasters "IndyWatch Feed Health"

VIDEO: Fire/Cooking Disaster Supplies Amy Alton ARNP asks: What should you have in your disaster supply storage to help you keep your family  in hot meals even when youre off the grid? In this video, Nurse Amy gives her thoughts on what the well-prepared family needs to function in the aftermath of a major disaster. To watch, click below: Heres wishing you the best of health in good times or bad, Amy and Joe Alton For more advice on disaster

[... Continue Reading]

00:39

Steemit Group Raising Funds for Family Protection Who Are They? "IndyWatch Feed Health"

steemit-family-protection

The Steemit Family Protection group asks people to donate cryptocurrency earned on Steemit to their cause of Family Protection and claims to have already raised over $29,000.00 worth of cryptocurrency. But when we asked for more information about who runs this group, we were met with resistance.

by Brian Shilhavy
Editor, Health Impact News

The Fake News wars are raging in full force these days, as the corporate-sponsored mainstream media fights to hang on to its influence in American culture, using the term Fake News to refer to anyone outside of their influence who publishes material contrary to their own agendas.

They are exerting extreme pressure on social media giants such as Facebook and Google-owned YouTube, where the term Fake News is being used to censor content that they deem fake or false.

As a result, many are looking for alternative platforms to exchange the free-flow of information without centralized authoritarian censorship based on political views and ideology.

A new kind of social media platform that was started in 2016 is Steemit, which is based on blockchain technology, the same technology used for cryptocurrencies, like Bitcoin.

There are many advantages advertised for this new technology, and because it is community-driven, it is seen by many as an alternative to current social media networks that are controlled from the top down, which can lead to censorship based on the political views of those who control the platform.

But Steemits biggest advantage is seen in the ability of its users to earn rewards (cryptocurrency) for themselves for participating in the network. From Steemits FAQ:

What is Steemit.com?

Steemit has redefined social media by building a living, breathing, and growing social economy a community where users are rewarded for sharing their voice. Its a new kind of attention economy.

How does Steemit work?

...

Tuesday, 20 March

23:13

Zerumbone is a promising phytoagent for development of new therapeutics for oral squamous cell carcinoma treatment. "IndyWatch Feed Health"

PMID:  Phytomedicine. 2018 Jan 15 ;39:33-41. Epub 2017 Dec 9. PMID: 29433681 Abstract Title:  Zerumbone targets the CXCR4-RhoA and PI3K-mTOR signaling axis to reduce motility and proliferation of oral cancer cells. Abstract:  BACKGROUND: The CXCR4-RhoA and PI3K-mTOR signaling pathways play crucial roles in the dissemination and tumorigenesis of oral squamous cell carcinoma (OSCC). Activation of these pathways have made them promising molecular targets in the treatment of OSCC. Zerumbone, a bioactive monocyclic sesquiterpene isolated from the rhizomes of tropical ginger, Zingiber zerumbet (L.) Roscoe ex Sm. has displayed promising anticancer properties with the ability to modulate multiple molecular targets involved in carcinogenesis. While the anticancer activities of zerumbone have been well explored across different types of cancer, the molecular mechanism of action of zerumbone in OSCC remains largely unknown.PURPOSE: Here, we investigated whether OSCC cells were sensitive towards zerumbone treatment and further determined the molecular pathways involved in the mechanism of action.METHODS: Cytotoxicity, anti-proliferative, anti-migratory and anti-invasive effects of zerumbone were tested on a panel of OSCC cell lines. The mechanism of action of zerumbone was investigated by analysing the effects on the CXCR4-RhoA and PI3K-mTOR pathways by western blotting.RESULTS: Our panel of OSCC cells was broadly sensitive towards zerumbone with ICvalues of less than 5 M whereas normal keratinocyte cells were less responsive with ICvalues of more than 25M. Representative OSCC cells revealed that zerumbone inhibited OSCC proliferation and induced cell cycle arrest and apoptosis. In addition, zerumbone treatment inhibited migration and invasion of OSCC cells, with concurrent suppression of endogenous CXCR4 protein expression in a time and dose-dependent manner. RhoA-pull down assay showed reduction in the expression of RhoA-GTP, suggesting the inactivation of RhoA by zerumbone. In association with this, zerumbone also inhibited the PI3K-mTOR pathway through the inactivation of Akt and S6 proteins.CONCLUSION: We provide evidence that zerumbone could inhibit the activation of CXCR4-RhoA and PI3K-mTOR signaling pathways leading to the reduced cell viability of OSCC cells. Our results suggest that zerumbone is a promising phytoagent for development of new therapeutics for OSCC treatment.

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22:51

Zerumbone suppresses angiogenesis in hepatocellular carcinoma cells. "IndyWatch Feed Health"

PMID:  Pharmacogn Mag. 2018 Jan ;13(Suppl 4):S731-S736. Epub 2018 Jan 31. PMID: 29491625 Abstract Title:  Zerumbone Suppresses Angiogenesis in HepG2 Cells through Inhibition of Matrix Metalloproteinase-9, Vascular Endothelial Growth Factor, and Vascular Endothelial Growth Factor Receptor Expressions. Abstract:  Context: Due to increase in the number of patients with impaired immunity, the incidence of liver cancer has increased considerably.Aims: The aim of this study is the investigation theanticancer effect of zerumbone (ZER) on hepatocellular carcinoma (HCC).Materials and Methods: The anticancer mechanism of ZER was determined by the rat aortic ring, human umbilical vein endothelial cells (HUVECs) proliferation, chorioallantoic membrane, cell migration, and proliferation inhibition assays.Results: Our results showed that ZER reduced tube formation by HUVECs effectively inhibits new blood vessel and tissue matrix formation. Western blot analysis revealed that ZER significantly (

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22:25

Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha. "IndyWatch Feed Health"

PMID:  Sci Rep. 2018 Mar 6 ;8(1):4090. Epub 2018 Mar 6. PMID: 29511228 Abstract Title:  Zerumbone reduces proliferation of HCT116 colon cancer cells by inhibition of TNF-alpha. Abstract:  Zerumbone is a known anti-cancer herbal compound. However, the actual protein target is not fully understood or known. This investigation focus on the association of zerumbone in HCT116 colon cancer cell proliferation and its link with TNF-alpha. The study shows that with the increasing concentration of zerumbone, there was a reduction of HCT116 cells proliferation based on the cell line study and hence higher TNF-alpha inhibition based on the TNF-alpha assay. The study also emphasizes on the computational aspect by investigating the molecular docking analysis of zerumbone against TNF-alpha. The docked complex was further validated using molecular dynamics simulation studies. The docking analysis observed that alpha-beta unsaturated carbonyl scaffold is an important moiety for the anti-cancer activity of zerumbone. Furthermore, the DFT analysis also confirms the reactivity nature of zerumbone based on the frontier molecular orbital analysis.

read more

08:59

Another Large Study Links Cancer To Vitamin D Levels "IndyWatch Feed Health"

There are now thousands of references in medical literature that show vitamin D's effectiveness--both for the prevention and treatment of cancer. Another large study shows that Vitamin D levels could have a direct influence in your risk of developing cancer, according to the results of a Japanese cohort study.

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