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PMID: Radiat Prot Dosimetry. 2017 Nov 1 ;177(1-2):63-68. PMID: 28981841 Abstract Title: CANADIAN POPULATION RISK OF RADON INDUCED LUNG CANCER-VARIATION RANGE ASSESSMENT BASED ON VARIOUS RADON RISK MODELS. Abstract: To address public concerns regarding radon risk and variations in risk estimates based on various risk models available in the literature, lifetime lung cancer risks were calculated with five well-known risk models using more recent Canadian vital statistics (5-year averages from 2008 to 2012). Variations in population risk estimation among various models were assessed. The results showed that the Canadian population risk of radon induced lung cancer can vary from 5.0 to 17% for men and 5.1 to 18% for women based on different radon risk models. Averaged over the estimates from various risk models with better radon dosimetry, 13% of lung cancer deaths among Canadian males and 14% of lung cancer deaths among Canadian females were attributable to long-term indoor radon exposure.
PMID: J Cancer Prev. 2017 Dec ;22(4):234-240. Epub 2017 Dec 30. PMID: 29302581 Abstract Title: Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure. Abstract: Background: Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic alterations induced by radon exposure are associated with the susceptible risk of lung cancer in never smokers.Methods: To accurately identify mutations within individual tumors, next generation sequencing was conduct for 19 pairs of lung cancer tissue. The associations of germline and somatic variations with radon exposure were visualized using OncoPrint and heatmap graphs. Bioinformatic analysis was performed using various tools.Results: Alterations in several genes were implicated in lung cancer resulting from exposure to radon indoors, namely those in epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), NK2 homeobox 1 (NKX2.1), phosphatase and tensin homolog (PTEN), chromodomain helicase DNA binding protein 7 (CHD7), discoidin domain receptor tyrosine kinase 2 (DDR2), lysine methyltransferase 2C (MLL3), chromodomain helicase DNA binding protein 5 (CHD5), FAT atypical cadherin 1 (FAT1), and dual specificity phosphatase 27 (putative) (DUSP27).Conclusions: While these genes might regulate the carcinogenic pathways of radioactivity, further analysis is needed to determine whether the genes are indeed completely responsible for causing lung cancer in never smokers exposed to residential radon.
Dane Wigington GeoengineeringWatch.org Countless forms of environmental contamination are taking their toll on the health and cognitive function of populations. But is this actually the primary factor behind the perplexing and willful blindness of the masses? As the ancient saying goes, "Nero fiddled while Rome burned, overall human nature has not changed. The flow of dire headlines
PMID: Cancer Treat Res. 2018 ;173:53-72. PMID: 29349758 Abstract Title: Is DCIS Overrated? Abstract: Ductal carcinoma in situ (DCIS), the noninvasive form of breast cancer (BC), comprises just over 20% of breast cancer cases diagnosed each year in the USA. Most patients are treated with local excision of the disease followed by whole breast radiation therapy. Total mastectomy is not an uncommon approach, and total mastectomy with a contralateral risk-reducing mastectomy has been on the rise in the past decade. In estrogen receptor-positive disease, patients are often offered endocrine ablative therapy with a selective estrogen receptor modulator or an aromatase inhibitor as both treatment and prevention. Local regional treatment options have no impact upon ultimate overall survival. Long-term survival rates are higher in patients with DCIS than with any other form of the disease. Are these strikingly high success rates a testament to effective treatment strategies or is there a significant subset of DCIS that was unlikely to ever progress to invasive ductal carcinoma? DCIS was not seen in the US prior to the advent of screening mammography. When compared to other countries, the USA has the highest utilization of screening mammography and the incidence rate of DCIS. Other lines of evidence include autopsy series examining the breast tissue of women who died of other causes, missed-diagnosis series and current retrospective reviews of DCIS, all align in support of the concept of DCIS as indolent in the majority of cases [3-14]. The evidence suggests that both patient and physician misconceptions about DCIS have led to overdiagnosis and over-treatment of DCIS. Recently, a gene expression profiling tool (12 gene assay, Oncotype DCIS) has emerged that shows considerable promise in predicting class in DCIS patients.
Legendary rocker Tom Petty passed away recently, on October 2, 2017 of cardiac arrest in his home in California. Now, some three months later, an autopsy has revealed the true cause of death to be accidental overdose on prescription medications.
Petty had a mixture of fentanyl, oxycodone, temazepam, alprazolam, citalopram, acetylfentanyl and despropionyl fentanyl in his system. The musician, 66, was found unconscious and in cardiac arrest at his Malibu home on Oct. 3 and died at the UCLA Medical Center that evening. [Source]
A social media post by his wife and daughter reveals this information and offers insight into what Petty was going through medically at the time of his death.
Our family sat together this morning with the Medical Examiner Coroners office and we were informed of their final analysis that Tom Petty passed away due to an accidental drug overdose as a result of taking a variety of medications.
Unfortunately Toms body suffered from many serious ailments including emphysema, knee problems and most significantly a fractured hip.
Despite this painful injury he insisted on keeping his commitment to his fans and he toured for 53 dates with a fractured hip and, as he did, it worsened to a more serious injury....
PMID: Clin Nutr. 2016 Jun ;35(3):615-25. Epub 2015 May 29. PMID: 26071633 Abstract Title: Effects of flaxseed supplements on blood pressure: A systematic review and meta-analysis of controlled clinical trial. Abstract: BACKGROUND & AIMS: Many experimental and clinical trials suggested that flaxseed might be a potent antihypertensive, but the evidences concerning the effects of flaxseed supplements on blood pressure (BP) has not been fully conclusive. We aimed to assess the impact of the effects of flaxseed supplements on blood pressure through systematic review of literature and meta-analysis of available randomized controlled trials (RCTs).METHODS: The literature search included PUBMED, Cochrane Library, Scopus, and EMBASE up to February 2015 to identify RCTs investigating the effect of flaxseed supplements on plasma blood pressure. Effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).RESULTS: 15 trials (comprising 19 treatment arms) with 1302 participants were included in this meta-analysis. Random-effects meta-analysis suggested significant reductions in both systolic BP (SBP) (WMD: -2.85 mmHg, 95%CI: -5.37 to -0.33, p = 0.027) and diastolic BP (DBP) (WMD: -2.39 mmHg, 95%CI: -3.78 to -0.99, p = 0.001) following supplementation with flaxseed products. When the studies were stratified according to their duration, there was a greater effect on both SBP and DBP in thesubset of trials with 12 weeks of duration (WMD: -3.10 mmHg, 95%CI: -6.46 to 0.27, p = 0.072 and -2.62 mmHg, 95%CI: -4.39 to -0.86, p = 0.003, respectively) vs the subset lasting
By Anna Hunt
A team of Danish and French researchers have found that ibuprofen may be one of the culprits responsible for male infertility. The study showed that daily intake of the drug creates a hormonal condition associated with impaired fertility, depression and increased risk of cardiovascular events.
Ibuprofen is one of the most common over-the-counter pain relief medicines. The medical industry categorizes it as a non-steroidal anti-inflammatory drug (NSAIDs). Because the drug is readily available without a prescription, most people think its safe. As well, with OTC drugs there is typically no medical professional to raise attention to the potential side-effects of the drug.
Scientific research has already implicated ibuprofen as having some negative effects on our health. Now, this new clinical study has found that ibuprofen may be one of the causes of male infertility. The research team writes:
Using a unique combination of a randomized, controlled clinical trial and ex vivo and in vitro approaches, we report a univocal depression of important aspects of testicular function, including testosterone production, after use of over-the-counter ibuprofen.
The study shows that ibuprofen use results in selective transcriptional repression of endocrine cells in the human test...
By Vera Sharav
Note from the WMP Team: In the coming days, WMP will republish Vera Sharavs Betrayal of Public Trust & Institutional Corruption: Vaccine Safety Assessments & Vaccine Science Falsified to Support Vaccination Policy originally published on the website: Alliance for Human Research Protection. Ms. Sharav is a Holocaust survivor and a fierce critic of the medical establishment. Her research is a must-read by those in our community because it explains the intricate groundwork that has led us to the debacle we are now living with an epidemic of sick children. Through understanding the past, we can change the future.
Following is the first of a seven-part series of Sharavs in-depth expos of the complex and widespread corruption that exists in the vaccination program. Her investigation has uncovered decades-long fraudulent activity that has permeated the vaccine industry.
Sharavs Introduction: I have undertaken this review of the case against Dr. Andrew Wakefield because the issues involved are far more consequential than the vilification of one doctor. The issues, as I see them, involve (a) collusion of public health officials to deceive the public by concealing scientific evidence that confirms empirical evidence of serious harm linked to vaccines in particular polyvalent vaccines; (b) the willful blindness by the medical community as it uncritically fell in line with a government dictated vaccination policy driven by corporate business interests.
Public health officials and the medical profession have abrogated their professional, public, and human responsibility, by failing to honestly examine the iatrogenic harm caused by expansive, indiscriminate, and increasingly aggressive vaccinatio...
Tom Pettys autopsy results indicate that he died from an apparent accidental drug overdose. The 66-year-olds heart stopped as a result of taking a variety of medications prescribed to him due to several serious ailments. The L.A. County Coroner says some of Toms organs failed due to mixed drug toxicity. The official autopsy report reveals that 
Wars are won by making political alliances. If our side EVER wants to win we need to understand that simple fact. By Kent Heckenlively, JD Its not the differences with your allies which should worry you, but the DESTRUCTION your common enemy has planned for everybody who is even remotely on your side. With the establishment on Continue reading President Trump Drops NUCLEAR BOMB on Vaccine Mandates
The post President Trump Drops NUCLEAR BOMB on Vaccine Mandates appeared first on BolenReport.
Your government is watching and tracking your decisions even saying "No" to vaccines.
The Centers for Disease Control has been quietly rolling out a nationwide program called the Immunization Information Systems (IIS), registering your vaccine information into a database.  This effort has been run in parallel with state vaccine registry implementations.
What is the intention of such programs?
My colleague Leslie Manookian, writer and director of the movie The Greater Good, wrote in a recent article, the "CDC has openly stated that vaccine registries are a tool to identify areas of 'undervaccination' so that they can be 'addressed' and brought into 'compliance.'" 
The Spotsylvania Board of Supervisors will meet on January 23rd at 6:00 p.m. in the Holbert Building.
There are several public presentations. Of note, the Human Resource Director will present findings from the Total Compensation Study covering County employee benefits recommendations.
Another is a presentation on fluoride in our county drinking water. The District Health Departments recommendation is to maintain public drinking water treatment in line with requirements and recommendations of local, state, and federal agencies.
Approval of Agenda
Public Presentations 6:02 PM (3 minutes per speaker)
Approval of the Consent Agenda (Action Items)
The week at Retraction Watch featured a researcher whose ideas were stolen at least three times, a victory for Crossfit in its attempt to reveal peer reviewers, and the second delisting of a cancer journal by an index that praised it just months ago. Heres what was happening elsewhere: Peer review trains scientists to respond 
The post Weekend reads: Why scientists respond badly to criticism; hidden retractions; journal cancels issue appeared first on Retraction Watch.
From Asia Times: In his new book The Playstation Dreamworld, Alfie Brown discusses the role of video games in both reinforcing and challenging capitalism through the lens of Freudian dream analysis.
Video games are a form of enjoyment in which the player experiences the wishes and desires of another as the wishes and desires of the players own, if even in a momentary or unconscious way, Bown claims.
Games are experienced actively rather than passively, and any apparent agency over a game is illusory as the player controls neither the environment nor the plot or outcome, as in dreams.
Just as a misreading of dreams can lead one into falsely believing things about oneself, video games are most dangerous in their capacity to force a desire onto the player while misleading them into thinking of it as their own.
This week on MIA Radio, we interview Kelli Foulkrod. Kelli is the owner of the Organic Mental Health Center. She is a therapist, yoga teacher, and mental health paradigm shifter based in Austin, Texas. For the past 15 years, Kelli has worked in the mental health field and practised yoga. She has been integrating yoga and the healing arts into traditional psychotherapy for over eight years and is passionate about offering holistic mental health treatment options.
With many years experience in an academic research setting, Kelli bridges the gap between science and spirituality. Kelli has experience serving clients populations of pregnant and postpartum women, grief and loss, psychosis, homelessness, substance abuse, teens, couples, and groups. She offers individual, couples, and group psychotherapy services in addition to yoga therapy sessions, workshops, and retreats.
In this piece for The Guardian, Dean Burnett critiques Johann Haris new book challenging what we know about depression. According to Burnett, many of the points Hari presents as fringe or new information are already widely accepted.
Hari does make several valid points, in his defence. The claim that depression is purely a result of lowered serotonin levels is indeed one that can and should be challenged. Antidepressant use isnt effective for everyone, and even if youre taking them the problem theyre supposed to be addressing can often return or eventually get worse. External factors in your life can be a big part, if not the main part, of an eventual depression diagnosis. This is all true.
However, despite Haris prose suggesting hes uncovered numerous revelations, pretty much everything he reveals is well known already.
By Dr. Mercola
If the popping or cracking sounds of your joints have ever given you cause for worry, youll be relieved to know that it is normal for your joints to occasionally talk to you. It is common to hear occasional joint sounds when you move in everyday ways, such as bending over to retrieve a dropped item or walking up or down stairs. Dr. William Shiel, chief editor and co-founder of the medical-information website MedicineNet.com, says:1
The symptom of joint cracking is described differently by different people, while nevertheless representing the same condition. Various descriptions for the same process include popping, exploding, noise, snapping and creaking of a joint.
The most common and less serious joint popping that occurs most often is caused by knuckle cracking or a certain manner of bending or twisting the body to relieve pressure.
One cause for the sounds is the reality that your soft tissues, such as ligaments and tendons, frequently contact your bones and other tissues as you move. Pockets of nitrogen gas within your joint fluid, which help with joint lubrication and nutrition, can also be responsible for some of the sounds.
To date there is insufficient evidence linking joint sounds and arthritis. Furthermore, cracking your joints does not cause them to swell up or become arthritic. That said, unless you are experiencing pain and swelling, rest assured that most joint sounds generally are normal, not harmful.
Dr. Aman Dhawan, an orthopedic sports-medicine specialist at Penn State Health Milton S. Hershey Medical Center, says, Joint sounds are not really an indicator of health or lack of health.2
In terms of cracking your joints, there is insufficient evidence to support the belief that it causes cartilage to wear down or that it will permanently loosen the joints. It may be irritating to the listener, but thats a separate issue, Dhawan notes. There is really no evidence that it causes any damage.3 As you may imagine, noisy joints can be of concern if the sounds are unusual or they are accompanied by acute pain and...
30 Tips in 30 Days Designed to Help You Take Control of Your Health
This article is part of the 30 Day Resolution Guide series. Each day a new tip will be added designed to help you take control of your health. For a complete list of the tips click HERE
By Dr. Mercola
Did you know the energy from the Earth can help you live a healthier life? The concept is known as earthing or grounding, which is no more complicated than walking barefoot.
In "Down to Earth"1 which received the IndieFEST Award of Excellence for a documentary short in January 20172 I speak alongside other experts to shed light on this super simple yet commonly overlooked way to protect and improve human health. As cardiologist Dr. Stephen Sinatra, author of "Earthing: The Most Important Health Discovery Ever?" explains in the film:
"[G]rounding is literally putting your bare feet on the ground. When you do that, you're in contact with the Earth, and mother Earth is endowed with electrons, and these electrons are literally absorbed through your feet. It's like taking handfuls of antioxidants, but you're getting it through your feet."
Research suggests a general lack of grounding, also referred to as "electron deficiency syndrome," has a lot to do with the rise of modern diseases. For a visual demonstration of this concept, see this previous article, which features an experiment conducted by Gary Schwartz, Ph.D., at the University of Arizona. Using sunflowers, he demonstrates the biological effects of grounding and what happens when the flowers are not grounded.
It's not unusual for Americans to spend entire days without being grounded. But though it has become the norm, it's completely unnatural, and didn't really become widespread until the advent of shoes with artificial soles that prevent grounding. When you're grounded, free electrons from the Earth are transferred into your body, and these free electrons are among the most potent antioxidants known to man.
As electrons are negatively charged and free radicals are positively charged, any fre...
the numbers of Nissl bodies in neurons in the hippocampus and cortex of
brains from both adult rats and their pups with fluorosis were lowered.
Such reduction in Nissl bodies, showing large granular bodies consisting
of rough endoplasmic reticulum with rosettes of free ribosomes
carrying out protein synthesis, indicates injury of neurons .
In cerebral cortex of the rats, treated with 100 ppm of sodium fluoride, there was disorganization of granular cell layer. The granule cells were accumulated in the form of clumps. Some pyramidal neurons showed chromatolysis (Fig. 2) and were shrunken with vacuolation around them (Fig. 4). The nuclei of some pyramidal neurons were eccentric in neuroplasm and others were showing necrosis. Some granule cells were swollen in shape and size (Fig. 5).
In rats treated with 200 ppm of sodium fluoride, the blood capillaries were constricted with narrow lumen and perivascular empty spaces were observed in the cerebral cortex.
Some glial cells appeared as darkly stained with dot like shrunken nuclei and empty spaces around them (Fig. 8).
The neuronal degeneration and hypertrophy with perineuronal empty spaces were visible in the pyramidal neuron (Fig. 11). In cerebral cortex, some area showed necrosis with complete disintegration of neuropil accompanied by loss of glial cells (Fig.12).
The pyramidal neurons in some area showed hyperchromatic and hypertrophic nucleus that was filling entire neuroplasm (Fig. 13). There were visible rounded fluid filled areas showing gliosis having debris of glial cells. The pyramidal neurons were distorted with spindle shape structure having elongated nucleus (Fig. 14).
In rats treated with 300 ppm of sodium fluoride, cerebral cortex contained the glial cells that were small, deeply stained and dot like structure with vacuolated areas around them (Fig. 15). The neuropil showed degeneration in the form of spiral structure surrounded by microglial cells (Fig. 16). At some locations eosinophilic neurons were visible in neuropil. Area of neuroplasm of some neuron was covered by darkly stained swollen large sized nucleus. Clear halos were visible around some neurons (Fig. 17). A few neurons exhibited degeneration at some locations in neuropil (Fig. 18). In some pyramidal neurons distorted nuclei were shifted to periphery. Chromatolysis visible in some granule cells (Fig. 19).
PMID: Integr Med Res. 2017 Dec ;6(4):354-360. Epub 2017 Aug 1. PMID: 29296562 Abstract Title: The potential for interaction of tolbutamide with pomegranate juice against diabetic induced complications in rats. Abstract: Background: Pomegranate can inhibit cytochrome P450 (CYP) 2C9 activity, which is largely responsible for the metabolism of sulfonylureas. The present study was undertaken to evaluate the pharmacokinetic and pharmacodynamic interaction of pomegranate and tolbutamide (TOL) against diabetic-induced complications.Methods: Diabetes was induced via administration of alloxan (150 mg/kg, intraperitoneally). Rats (n = 8) were treated with pomegranate juice (PJ) [3 mL/animal, per os (p.o.)], TOL (20 mg/kg, p.o.), and their combination for 4 weeks. Twenty-four hours after the last treatment, the pharmacodynamic interaction of PJ and TOL was evaluated by antinociceptive activity, electrocardiographic parameters, serum glucose, biomarkers, and lipid profile values. The influence of PJ on the pharmacokinetics of TOL was studied using the high performance liquid chromatography method.Results: The combination of PJ and TOL resulted in a significant improvement against diabetic complications compared to the group treated with TOL alone. The combination group was found to be the best protective group by significant improvement of antinociceptive activity, restoration of electrocardiographic parameters, serum glucose, biomarkers, and lipid profile compared to the group treated with TOL alone. Results of the pharmacokinetic study revealed that PJ increases bioavailability and half-life, along with a decrease in clearance and elimination rate of TOL.Conclusion: From this study, it can be concluded that the combination of PJ and TOL exhibited profound protection compared to TOL alone against diabetic complications. The findings of pharmacokinetic interaction justified the results of pharmacodynamic interaction.
PMID: Oxid Med Cell Longev. 2017 ;2017:6063201. Epub 2017 Nov 30. PMID: 29333211 Abstract Title: Pomegranate Juice Prevents the Formation of Lung Nodules Secondary to Chronic Cigarette Smoke Exposure in an Animal Model. Abstract: Background: Cigarette smoke (CS) induces an oxidative stress, DNA damage, and lung cancer. Pomegranate juice (PJ) possess potent antioxidant activity attributed to its polyphenols. We investigated whether PJ supplementation would prevent the formation of lung nodules, attenuate mitotic activity, and reduce hypoxia-inducible factor-1 (HIF-1) expression secondary to CS exposure in an animal model.Methods: Mice were divided into: Control group, CS group, CS+PJ group, and PJ-only group. CS and CS+PJ were exposed to CS, 5 days per week, for a total of 5 months. Animals were then housed for additional four months. CS+PJ and PJ groups received PJ throughout the experiment period while others received placebo. At the end of the experiment, the incidence of lung nodules was assessed by (1) histological analysis, (2) mitotic activity [measurement of PHH3 antibodies], and (3) measurement of HIF-1 expression.Results: The incidence of lung nodules was significantly increased in CS. CS exposure significantly increased PHH3 and HIF-1 expression. PJ supplementation attenuated the formation of lung nodules and reduced PHH3 and HIF-1 expression.Conclusion: PJ supplementation significantly decreased the incidence of lung cancer, secondary to CS, prevented the formation of lung nodules, and reduced mitotic activity and HIF-1 expression in an animal model.
Fluoride has become a menace for the people of Sandhibahal and Dangbahal gram panchayats under the Bijepur Assembly constituency in Bargarh district, which is going for a by-election.
Most people here are suffering from a silent killer disease called fluorosis, but the pre-election propaganda by different political parties does not reveal that they are in anyway concerned at all of this long standing problem of the people.
Take the case of Jamutbahal, Jadamunda and Banchhanagar villages of Sandhibahal panchayat, where people irrespective of their ages have been affected by the dreaded disease. The official website on the National Rural Drinking Water Projects (NRDWP) of the Union Ministry of Drinking Water Supply (MDWS) reveals that six out of ten drinking water sources of the Jamutbahal village are not fit for drinking. But due to non-availability of any other secured sources, the villagers here are forced to drink the water of these contaminated sources.
Likewise, in Banchhanagar village, one of the four hand pumps is functional and considered to be safe. Chakradihi village has six tube wells, out of which only one is functional. Problems in all other villages of the panchayat are alike. Test reports of water samples of some of the sources tested in the district headquarters water testing lab reveal that most of the sources are above the permissible level of 1.5 mg/L fluoride content.
The water sources in these panchayats have been created under three schemes the PWS scheme, Hand pump scheme and Open well/other scheme. Hand pump scheme has the highest number of sources. In Sandhibahal panchayat, there are 39 hand pumps and two PWS sources. About Rs 1.29 crore has been spent in total in creation of water facilities in the panchayat till now.
There are 44 drinking water sources in Dangbahal GP, which includes one PWS project. An amount of Rs 29.37 lakh has been spent in creation of these sources. But the problems remain intact. Unless the drinking water sources are changed the problems would remain, say the villagers.
The impact of fluoride is clearly visible in people, even within children. Almost all the children have disfigured/stained teeth, which can be considered the beginning of fluorosis. Although the skeletal deformities are visible in people above 30 years, the symptoms start in their twenties. The people reveal that, it all starts from pain in waist and joints which gradually converts to stiffness and deformity.
Laxman Haripal of Banchhanagar village is only 25 yars old, but fluorosis has already deformed his arms. Bhanati Mahapatra (27) has severe pain in her waist, and she cannot bend. Digambar Rana, in his late twenties, has pain in his heels and so, has difficulty in walking. Dilip Maha...
PMID: Am J Epidemiol. 2017 Sep 1 ;186(5):532-540. PMID: 28541391 Abstract Title: Rotating Night-Shift Work and the Risk of Breast Cancer in the Nurses' Health Studies. Abstract: In 2007, the International Agency for Research on Cancer declared shift work that involved circadian disruption to be a"probable"carcinogen (group 2A), noting that human evidence was limited. Using data from 2 prospective cohort studies, the Nurses' Health Study (1988-2012; n = 78,516) and Nurses' Health Study II (1989-2013; n = 114,559), we examined associations between rotating night-shift work and breast cancer risk. In the 2 cohorts, there were a total of 9,541 incident invasive breast malignancies and 24 years of follow-up. In the Nurses' Health Study, women with 30 years or more of shift work did not have a higher risk of breast cancer (hazard ratio (HR) = 0.95, 95% confidence interval (95% CI): 0.77, 1.17; P for trend = 0.63) compared with those who never did shift work, although follow-up occurred primarily after retirement from shift work. Among participants in the Nurses' Health Study II, who were younger than participants in the other cohort, the risk of breast cancer was significantly higher in women with 20 years or more of shift work at baseline, reflecting young-adult exposure (HR = 2.15, 95% CI: 1.23, 3.73; P for trend = 0.23), and was marginally significantly higher for women with 20 years or more of cumulative shift work when we used updated exposure information (HR = 1.40, 95% CI: 1.00, 1.97; P for trend = 0.74). In conclusion, long-term rotating night-shift work was associated with a higher risk of breast cancer, particularly among women who performed shift work during young adulthood. Further studies should explore the role of shift work timing on breast cancer risk.
Dr. Sebi spoke against parsley. However, it once ended up on the list and can probably be seen on other lists that are presented as foods recommended by Dr. Sebi. Recommended food lists from a Dr. Sebi perspective will need a comprehensive review because of at least two reasons: (1) Continue reading
PMID: Toxicol Lett. 2018 Jan 2 ;285:81-86. Epub 2018 Jan 2. PMID: 29305326 Abstract Title: Neonatal exposure to bisphenol A alters the hypothalamic-pituitary-thyroid axis in female rats. Abstract: Bisphenol A (BPA) is a component of polycarbonate plastics, epoxy resins and polystyrene found in many common products. Several reports revealed potent in vivo and in vitro effects. In this study we analyzed the effects of the exposure to BPA in the hypothalamic-pituitary-thyroid axis in female rats, both in vivo and in vitro. Female Sprague-Dawley rats were injected sc from postnatal day 1 (PND1) to PND10 with BPA: 500g 50l-1 oil (B500), or 50g 50l-1 (B50), or 5g 50l-1 (B5). Controls were injected with 50l vehicle during the same period. Neonatal exposure to BPA did not modify TSH levels in PND13 females, but it increased them in adults in estrus. Serum T4 was lower in B5 and B500 with regards to Control, whereas no difference was seen in T3. No significant differences were observed in TRH, TSH and TRH receptor expression between groups. TSH release from PPC obtained from adults in estrus was also higher in B50 with regard to Control. In vitro 24h pre-treatment with BPA or E2 increased basal TSH as well as prolactin release. On the other hand, both BPA and E2 lowered the response to TRH. The results presented here show that the neonatal exposure to BPA alters the hypothalamic pituitary-thyroid axis in adult rats in estrus, possibly with effects on the pituitaryand thyroid. They also show that BPA alters TSH release from rat PPC through direct actions on the pituitary.
PMID: Aliment Pharmacol Ther. 2018 Jan 11. Epub 2018 Jan 11. PMID: 29322544 Abstract Title: Role of bisphenol A as environmental factor in the promotion of non-alcoholic fatty liver disease: in vitro and clinical study. Abstract: BACKGROUND: Bisphenol A is an endocrine disrupting chemical associated with type 2 diabetes mellitus (T2DM), cardiovascular disease and liver enzyme abnormalities.AIM: To evaluate bisphenol A plasma and urine levels in non-alcoholic fatty liver disease (NAFLD) patients compared to healthy subjects. Furthermore, we evaluated, in human HepG2 cells, the effects of exposure to different concentrations of bisphenol A on both oxidative stress induction and cell proliferation.METHODS: We enrolled 60 patients with histological diagnosis of NAFLD with or without T2DM and sixty healthy subjects. In vitro, the proliferation of bisphenol A-exposed HepG2 cells at two different concentrations (0.025 and 0.05 M) was evaluated, both at high (H-HepG2) and at low (L-HepG2) glucose concentrations for 48 h. Lipoperoxidation was assessed by thiobarbituric acid reactive substances (TBARS) assay.RESULTS: Bisphenol A levels were significantly higher in 60 NAFLD subjects, both in urine and in plasma (P
PMID: Sci Rep. 2018 Jan 11 ;8(1):490. Epub 2018 Jan 11. PMID: 29323181 Abstract Title: Oral exposure of low-dose bisphenol A promotes proliferation of dorsolateral prostate and induces epithelial-mesenchymal transition in aged rats. Abstract: Bisphenol A (BPA) is a well-known endocrine disruptor compound reported to have prostate toxicity. This study aimed to assess the effect of BPA on the proliferation of dorsolateral prostate (DLP) and the expression of epithelial-mesenchymal transition (EMT)-related genes in aged rats. Male aged SD rats were treated with BPA (10.0, 30.0, and 90.0g/kg i.g., daily) or vehicle (i.g., daily) for 3 months. Treatment with BPA resulted in increased the expression of PCNA, DLP weight and DLP epithelial height compared with the control group (P
PMID: Environ Mol Mutagen. 2017 Dec 29. Epub 2017 Dec 29. PMID: 29285797 Abstract Title: Sodium fluoride disturbs DNA methylation of NNAT and declines oocyte quality by impairing glucose transport in porcine oocytes. Abstract: Sodium fluoride (NaF) is used as a medicine to prevent tooth decay; however, excessive NaF could cause a pathological damage to the health. Recent studies showed that NaF impaired mouse oocyte maturation, included of abnormal spindle configuration, actin cap formation, cortical granule-free domain formation, and the following development after fertilization. However, few studies used large animals as models to study the toxicology of NaF on oocytes maturation. We proposed a hypothesis that NaF would affect the nuclear and cytoplasmic maturation of porcine oocytes and DNA methylation pattern of imprinted genes in oocytes. Our results showed that NaF affected cumulus expansion, polar body emission, spindle morphology, cortical granule distribution, early apoptosis, and the following development after parthenogenetic activation during porcine oocyte maturation. Moreover, NaF increased the DNA methylation of NNAT and decreased its expression, which disturbed the glucose transport in oocytes. These results suggest that NaF impairs the porcine oocytes maturation epigenetically, which provides a new toxicological mechanism of NaF on the oocyte maturation. Environ. Mol. Mutagen, 2017. 2017 Wiley Periodicals, Inc.
PMID: Occup Environ Med. 2017 Sep ;74(9):680-683. Epub 2017 Jun 26. PMID: 28652381 Abstract Title: Oxidative DNA damage during night shift work. Abstract: OBJECTIVES: We previously reported that compared with night sleep, day sleep among shift workers was associated with reduced urinary excretion of 8-hydroxydeoxyguanosine (8-OH-dG), potentially reflecting a reduced ability to repair 8-OH-dG lesions in DNA. We identified the absence of melatonin during day sleep as the likely causative factor. We now investigate whether night work is also associated with reduced urinary excretion of 8-OH-dG.METHODS: For this cross-sectional study, 50 shift workers with the largest negative differences in night work versus night sleep circulating melatonin levels (measured as 6-sulfatoxymelatonin in urine) were selected from among the 223 shift workers included in our previous study. 8-OH-dG concentrations were measured in stored urine samples using high performance liquid chromatography with electrochemical detection. Mixed effects models were used to compare night work versus night sleep 8-OH-dG levels.RESULTS: Circulating melatonin levels during night work (mean=17.1ng/mg creatinine/mg creatinine) were much lower than during night sleep (mean=51.7ng/mg creatinine). In adjusted analyses, average urinary 8-OH-dG levels during the night work period were only 20% of those observed during the night sleep period (95% CI 10% to 30%; p
PMID: Chemosphere. 2018 Jan 8 ;197:117-122. Epub 2018 Jan 8. PMID: 29334651 Abstract Title: Effects of perinatal fluoride exposure on the expressions of miR-124 and miR-132 in hippocampus of mouse pups. Abstract: To investigate the effects of perinatal fluoride exposure on learning and memory ability of mouse offspring, ICR female mice were received different doses of sodium fluoride (0, 25, 50, 100mg/L NaF) from pregnant day 7 to lactational day 21. Pups were exposed to fluoride through the cord blood and breast milk. Open field test showed that compared to the control group, perinatal fluoride exposure significantly decreased the number of entries into the center zone in 100mg/L NaF group. In the eight-arm maze test, the number of working memory errors, reference memory errors, and the total arm entries were significantly increased in fluoride treatment groups, compared to the control group. Additionally, 100mg/L NaF significantly elevated the expression levels of miR-124, miR-132, and DiGeorge syndrome chromosomal region 8 (DGCR8) in hippocampus of mouse pups at postnatal day (PND) 21. Contrarily, methyl CpG binding protein 2 (MeCP2) were dramatically reduced in 50 and 100mg/L NaF groups, while cAMP-response element binding protein (CREB) mRNA level was significantlydecreased in all fluoride groups. These findings suggested that the impairment of learning and memory in mouse offspring induced by perinatal fluoride exposure may partly result from the enhanced miR-124 and miR-132 and the alterations of their target genes.
PMID: Health Promot Chronic Dis Prev Can. 2017 Aug ;37(8):238-247. PMID: 28800293 Abstract Title: Rotating shift work associated with obesity in men from northeastern Ontario. Abstract: INTRODUCTION: While some studies have suggested associations between shift work and obesity, few have been population-based or considered multiple shift schedules. Since obesity is linked with several chronic health conditions, understanding which types of shift work influence obesity is important and additional work with more detailed exposure assessment of shift work is warranted.METHODS: Using multivariate polytomous logistic regression, we investigated the associations between shift work (evening/night, rotating and other shift schedules) and overweight and obesity as measured by body mass index cross-sectionally among 1561 men. These men had previously participated as population controls in a prostate cancer case-control study conducted in northeastern Ontario from 1995 to 1999. We obtained information on work history (including shift work), height and weight from the existing self-reported questionnaire data.RESULTS: We observed an association for ever (vs. never) having been employed in rotating shift work for both the overweight (OR [odds ratio] = 1.34; 95% CI [confidence interval]: 1.05-1.73) and obese (OR = 1.57; 95% CI: 1.12-2.21) groups. We also observed nonsignificant associations for ever (vs. never) having been employed in permanent evening/night shifts. In addition, we found a significant trend of increased risk for both overweight and obesity with increasing duration of rotating shift work.CONCLUSION: Both the positive association between rotating shift work and obesity and the suggested positive association for permanent evening/night shift work in this study are consistent with previous findings. Future population-based research that is able to build on our results while examining additional shift work characteristics will further clarify whether some shift patterns have a greater impact on obesity than others.
PMID: mSystems. 2017 Jul-Aug;2(4). Epub 2017 Aug 8. PMID: 28808691 Abstract Title: Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. Abstract: Fluoridation of drinking water and dental products prevents dental caries primarily by inhibiting energy harvest in oral cariogenic bacteria (such as Streptococcus mutans and Streptococcus sanguinis), thus leading to their depletion. However, the extent to which oral and gut microbial communities are affected by host fluoride exposure has been underexplored. In this study, we modeled human fluoride exposures to municipal water and dental products by treating mice with low or high levels of fluoride over a 12-week period. We then used 16S rRNA gene amplicon and shotgun metagenomic sequencing to assess fluoride's effects on oral and gut microbiome composition and function. In both the low- and high-fluoride groups, several operational taxonomic units (OTUs) belonging to acidogenic bacterial genera (such as Parabacteroides, Bacteroides, and Bilophila) were depleted in the oral community. In addition, fluoride-associated changes in oral community composition resulted in depletion of gene families involved in central carbon metabolism and energy harvest (2-oxoglutarate ferredoxin oxidoreductase, succinate dehydrogenase, and the glyoxylate cycle). In contrast, fluoride treatment did not induce a significant shift in gut microbial community composition or function in our mouse model, possibly due to absorption in the upper gastrointestinal tract. Fluoride-associated perturbations thus appeared to have a selective effect on the composition of the oral but not gut microbial community in mice. Future studies will be necessary to understand possible implications of fluoride exposure for the human microbiome. IMPORTANCE Fluoride has been added to drinking water and dental products since the 1950s. The beneficial effects of fluoride on oral health are due to its ability to inhibit the growth of bacteria that cause dental caries. Despite widespread human consumption of fluoride, there have been only two studies of humans that considered the effect of fluoride on human-associated microbial communities, which are increasingly understood to play important roles in health and disease. Notably, neither of these studies included a true cross-sectional control lacking fluoride exposure, as study subjects continued baseline fluoride treatment in their daily dental hygiene routines. To our knowledge, this work (in mice) is the first controlled study to assess the independent effects of fluoride exposure on the oral and gut microbial communities. Investigating how fluoride interacts with host-associated microbial communities in this controlled setting represents an effort toward understanding how common environmental exposures...
While most Congressional observers are focused on the battle to avert a weekend government shutdown (an outcome thats looking increasingly likely), the Senate on Thursday quietly passed an extension of the NSAs spying surveillance program, sending the bill to the presidents desk a week after the House voted to authorize the controversial plan. Even President 
One of the questions that has puzzled the greatest minds in history is What is the meaning of life?. What is our true purpose on this earth, why are we here? Chances are youll get a different answer from almost every single person. Some people believe that money will help them find the answer, so... View Article
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PMID: Scand J Work Environ Health. 2017 Nov 1 ;43(6):560-568. Epub 2017 Sep 7. PMID: 28879368 Abstract Title: Shift work and the incidence of prostate cancer: a 10-year follow-up of a German population-based cohort study. Abstract: Objectives We investigated the association of shift and night work with the incidence of prostate cancer using data of the population-based prospective Heinz Nixdorf Recall Study from the highly industrialized Ruhr area in Germany. Methods Participants of the baseline survey were recruited between 2000-2003. A follow-up survey including, a detailed interview on shift and night work, was conducted from 2011-2014. We included 1757 men who did not report a history of prostate cancer at baseline. We assessed shift- and night-work exposure up to time of the baseline interview. Incident prostate cancers were recorded from baseline through September 2014. We calculated hazard ratios (HR) of shift- and night-work exposure using Cox proportional hazards regression with age at event as timescale, adjusting for smoking status, family history of prostate cancer, education (13, 14-17, 18 years), and equivalent income (low, medium, high). Results We observed a twofold increased HR for prostate cancer among shift and night workers. Ever employment in shift work was associated with HR 2.29, 95% confidence interval (CI) 1.43-3.67 and night work with HR 2.27, 95% CI 1.42-3.64. HR increased steadily with duration of employment in shift or night work. Stratifying analyses by preferred midpoint of sleep, yielded strongly elevated HR among subjects with early sleep preference, although these analyses were limited by small number of cases. Conclusions We identified increased risks for prostate cancer among men with employment in shift or night work. HR were strongly elevated among long-term employed shift workers and men with early preferred midpoint of sleep.
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