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Wednesday, 19 December


Holistic MD who founded Florida Marijuana Institute found dead of alleged suicide "IndyWatch Feed Health"

On Sunday, November 11th, 2018, Dr. Russell T. Bain, newly married and full of life, allegedly committed suicide by shooting himself in the head. There were no witnesses. From what we have been able to find, little to nothing was written up about him and four days after he died, his funeral services were held. []

The post Holistic MD who founded Florida Marijuana Institute found dead of alleged suicide appeared first on Health Nut News.


Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. "IndyWatch Feed Health"

PMID:  Int J Biol Macromol. 2018 Nov 8 ;123:81-90. Epub 2018 Nov 8. PMID: 30414900 Abstract Title:  Ginger polysaccharides induced cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. Abstract:  In this study, ginger polysaccharide (GP) was obtained from ginger by enzymatic method, its chemical properties and antitumor activity were investigated. The results indicated that the composition and proportion of GP were lrhamnose, darabinose, dmannose, dglucose and dgalactose in a molar ratio of 3.64:5.37:3.04:61.03:26.91, GP had the characteristic absorption peak of polysaccharide. Congo red experiment showed that GP had a triple helix structure, which could have anti-tumor effect. Furthermore, MTT assay, cell morphology observation, nuclear morphology observation and reactive oxygen species observation demonstrated that GP had significant antitumor effect. Flow cytometry suggested that GP could promote apoptosis and arrest cells in G0-G1 phase. Real-time fluorescence quantification and Westernblot revealed that GP could up-regulate the expression of Bax, Fas, FasL, caspase-3, p21 and p53, and down-regulate the expression of Bcl-2. These studies suggested that GP would be used as an antitumor drug in foods to promote the development of functional foods.

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Ginger is an alternative for the prevention of postoperative nausea and vomiting. "IndyWatch Feed Health"

PMID:  Phytomedicine. 2018 Nov 15 ;50:8-18. Epub 2018 Sep 5. PMID: 30466995 Abstract Title:  Ginger (Zingiber officinale): An alternative for the prevention of postoperative nausea and vomiting. A meta-analysis. Abstract:  BACKGROUND: Postoperative nausea and vomiting (PONV) is a distressing outcome related to surgeries. Traditionally, ginger has been used in the treatment of nausea and vomiting for thousands of years. Recently, several randomized, placebo-controlled clinical trials (RCTs) have been conducted to evaluate the efficacy of ginger in PONV.PURPOSE: To systematically evaluate the efficacy of ginger on postoperative nausea and vomiting (PONV) compared to placebo, based on RCTs.STUDY DESIGN: The meta-analysis was reported following the PRISMA guidelines using the PICO format, and it was registered with the PROSPERO register.METHODS: PubMed, Embase, the Cochrane Central Register of Controlled Trials and Web of Science were searched for relevant studies. Human, placebo-controlled clinical studies of patients undergoing any types of surgery, receiving pharmacological doses of ginger per os were included. Only clinical trials with explicit description of the ginger preparation used were analysed. No language or publication year restrictions was applied.RESULTS: Ten randomized trials including a total of 918 patients were pooled for the statistical analysis. The present meta-analysis supports that ginger has a significant effect on the severity of PONV based on visual analogue scale (VAS) results: in a fixed effects model the pooled standardized mean difference (SMD) was -0.247 (favouring ginger; [LL]: -0.455, [UL]: -0.040, p-value: 0.019). Moreover, our results suggest that ginger reduces the incidence of postoperative nausea and vomiting, as well antiemetic drug demand; however, these effects are not statistically significant compared to placebo, which may be explained by underdosing.CONCLUSIONS: According to our thorough meta-analysis ginger is safe and well tolerated, and decreases the severity of PONV, and may lower the incidence of postoperative nausea and vomiting, which in turn may reduce antiemetic drug demand, suggesting that ginger may be a useful alternative to antiemetic medications to alleviate PONV.

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6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2018 Nov ;107:1523-1529. Epub 2018 Sep 5. PMID: 30257370 Abstract Title:  6-Gingerol attenuates LPS-induced neuroinflammation and cognitive impairment partially via suppressing astrocyte overactivation. Abstract:  6-Gingerol, the major component of gingerols extracted from Zingiber officinale, has been shown to exhibit anti-inflammatory and antioxidant bioactivities. Since neuroinflammation plays an important role in neurodegenerative diseases, such as Alzheimer's disease (AD), and astrocytes have been considered important in the process of neurodegeneration, it was of interest to know whether 6-gingerol reduced astrocytes activation or even attenuated cognitive impairment. Here we examined the neuroprotective effects of 6-gingerol in lipopolysaccharide (LPS)-induced disorder models both in vitro and in vivo. C6 astroglioma cells treated with LPS were found to release excessive pro-inflammatory cytokines, including TNF- and IL-6, and also increase intercellular ROS, NO, and iNOS (i.e. NOS2). All these were blocked by 6-gingerol in a concentration-dependent manner. The spatial learning and memory of rats challenged with LPS (10g, i.c.v.) in the absence or presence of 6-gingerol were evaluated using the Morris water-maze (MWM) test. 6-Gingerol attenuated LPS-induced imapirement of MWM learning and memory in a dose-dependent manner. Besides, 6-gingerol inhibited LPS-induced increases in levels of GFAP and TNF- in the rat brain. The results suggest that 6-gingerol suppresses astrocyte overactivation, through which it contributes to improvement of cognitive ability.

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Ginger displayed significant efficacy with regard to controlling chemotherapy-induced nausea and vomiting in the experimental groups. "IndyWatch Feed Health"

PMID:  Cancer Nurs. 2018 Oct 6. Epub 2018 Oct 6. PMID: 30299420 Abstract Title:  Does the Oral Administration of Ginger Reduce Chemotherapy-Induced Nausea and Vomiting?: A Meta-analysis of 10 Randomized Controlled Trials. Abstract:  BACKGROUND: Preclinical tests in animals have shown that ginger extract can be used to treat chemotherapy-induced nausea and vomiting (CINV); however, research findings in clinical trials have not been conclusive.OBJECTIVE: Through this meta-analysis, we aimed to determine whether ginger could be used to treat CINV, which was interpreted using the PICOS (patient, problem/population, intervention, comparison, outcome, study) framework, with P being patients who underwent chemotherapy; I being 0.5 to 2.0 g/d of Zingiberaceae, Zintoma, dry ginger, ginger capsules, powdered ginger root, Zingiber officinale Roscoe, ginger extract, powdered ginger, 6-gingerol, or shogalos; C being placebo or standard care; and O being the relief, reduction, or improvement of CINV.METHOD: Via systematic literature review, we searched for studies in English from 2000 to 2017 in databases. We conducted a meta-analysis using Comprehensive Meta-analysis 2 on a total of 10 studies with complete data.RESULTS: The odds ratio (OR) of ginger in controlling CINV was 0.71 (95% confidence interval [CI], 0.54-0.94; P = .015). Heterogeneity existed among the samples; therefore, we proceeded with a subgroup analysis and divided nausea and vomiting into acute or delayed. The results revealed that ginger could only reduce acute CINV in patients (OR, 0.60; 95% CI, 0.42-0.86; P = .006), particularly acute vomiting (OR, 0.58; 95% CI, 0.37-0.94; P = .025).CONCLUSIONS: Ginger displayed significant efficacy with regard to controlling CINV in the experimental groups.IMPLICATIONS FOR PRACTICE: Our results could provide a reference for antiemetic methods to treat CINV and facilitate support for more clinical trials in the future to establish relevant guidelines.

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Tuesday, 18 December


Steamed ginger can decrease plasma total cholesterol and triglyceride and can inhibit liver steatosis by regulating the expressions of hepatic genes. "IndyWatch Feed Health"

PMID:  Nutr Res Pract. 2018 Dec ;12(6):503-511. Epub 2018 Nov 30. PMID: 30515278 Abstract Title:  The antioxidant activity of steamed ginger and its protective effects on obesity induced by high-fat diet in C57BL/6J mice. Abstract:  BACKGROUND/OBJECTIVES: Ginger, a root vegetable, is known to have antioxidant and antiobesity effects. Preparation, such as by steaming, can affect the chemical composition of prepared root vegetables or herbs and can change their functional activities. In the present study, we investigated the protective effects of steamed ginger against oxidative stress and steatosis in C57BL/6J mice fed a high-fat diet.MATERIALS/METHODS: The levels of polyphenols and flavonoids in two different extracts of steamed ginger,, water extract (SGW) and ethanolic extract (SGE); as well, their antioxidant activities were examined. Forty male C57BL/6J mice were fed a normal diet (ND, n = 10), high-fat diet (HFD, 60% fat, w/w, n = 10), HFD supplemented with 200 mg/kg of SGE or garcinia (GAR) by weight (SGED or GARD, respectively, n = 10) for 12 weeks. Serum chemistry was examined, and the expressions of genes involved in lipid metabolism were determined in the liver. Histological analysis was performed to identify lipid accumulations in epididymal fat pads and liver.RESULTS: The SGE had higher contents of polyphenols and flavonoids and higher DPPH and ABTSfree radical scavenging activities compared to those of SGW. Treatment with SGE or GAR significantly decreased the HFD-induced weight gain. Both SGE and GAR significantly reduced the high serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein levels induced by HFD. Compared to ND, HFD significantly increased hepatic TC and TG levels. SGE or GAR supplementation significantly decreased the increase of hepatic lipids by HFD. Interestingly, SGE had a more significant effect in reducing hepatic TC and TG levels than GAR. Furthermore, hepatic genes involved in lipogenesis and lipolysis were altered in both the SGED and GARD groups.CONCLUSIONS: The present study indicates that steamed ginger supplementation can decrease plasma TC and TG and can inhibit liver steatosis by regulating the expressions of hepatic genes.

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Africans Paid 69 Cents an Hour to be Bitten in GMO Mosquito Trial "IndyWatch Feed Health"


Human guinea pigs paid to expose themselves to mosquitoes that may carry malaria



Under the headline, Malaria trial pays Africans to be bitten, The Times of London reports that human guinea pigs in the West African state of Burkina Faso are being paid to expose themselves to mosquitoes that could potentially carry malaria or other diseases.

Although the Bill & Melinda Gates Foundation has invested $70 million in the project, The Times reports that about 25 African volunteers in the village of Bana are being paid just 69 cents (0.55) an hour to expose their legs for six hours a night to all mosquitoes in their local environment, as part of a GMO mosquito trial.

The villagers taking part have been given information sheets warning them that they could be bitten by a mosquito and be infected by malaria or another sickness transmitted by the mosquito.

According to The Times, for each six-hour shift, between dawn and dusk when the insects are most active, the villagers are paid just $4.17 (3.30) a night to compensate for fatigue and time given.

As part of this, they are expected to try and capture the mosquitoes that come to bite them. The information sheet also says they will be tested regularly for malaria.

The trial is being run by the Target Malaria consortium as a first step towards the deployment of so-called gene-drives that aim to eliminate whole species, in this case malaria-carrying mosquitoes.

The Times reports a number of other concerns about the project, quite apart from its use of poorly paid human guinea pigs:

Those opposed to tampering with mosquito genes cite the possibility of unforeseen consequences to the food chain. Mosquitoes pollinate flowers and are important food sources for fish, frogs, birds and bats. Ingeborg van Schayk, director of the Malaria Foundation, said:

We do not support the release of GM mosquitoes as long as the long-te...


Natural Remedies for Macular Degeneration and Healthy Vision "IndyWatch Feed Health"

Medical Education Chart of Biology for Human Eye internal Diagram. Vector illustration

by Paul Fassa
Health Impact News

Macular degeneration is the most common cause of blindness among people 55 and over who once had normal eyesight. Thats why it is often called age-related macular degeneration, or AMD. It can also occur rarely among younger people within a six to twenty year age span.

Conventional medicine is relatively clueless about its cause, blaming it on imply aging or genetics for younger victims. It also falls short of effectively avoiding or treating it, considering it to be incurable and only poorly managed with harsh treatments.

This article explores a newly discovered source of macular degeneration and its prevention as well as natural remedies that include eating the right foods and cannabis.

Basic Macular Degeneration Profile

Younger people do get macular degeneration, but rarely. Then its called Stargardt disease, named after Karl Stargardt, who first discovered the disease among his patients very early in the 20th Century. Though Stargardt disease is associated with a certain genetic disposition, materially it is still macular degeneration.  

The macula is located in the back of the eyes inner retina wall. It is responsible for receiving images that pass through pupil and lens, then translating the imagerys energy into nerve impulses that our brains translate into what we see. It connects us visually to what we see while looking straight ahead.

As the maculas cells degrade over time, clarity declines until central vision is completely lost with only relatively dim peripheral vision remaining. There are public health concerns that the United States current number of 11 million vision impaired from macular degeneration will double by 2050. 


Ginger as well as Novafen is effective in relieving pain in girls with primary dysmenorrhea. "IndyWatch Feed Health"

PMID:  Taiwan J Obstet Gynecol. 2018 Dec ;57(6):806-809. PMID: 30545531 Abstract Title:  Effect of Ginger and Novafen on menstrual pain: A cross-over trial. Abstract:  OBJECTIVE: Menstrual pain is a periodic pain which happens during the days of menses. The menstrual disturbances as a health problem among young girls affect not only reproductive, but also psychical health and quality of life. This study was done with the goal of comparing the effect of Ginger and Novafen on the menstrual pain.MATERIALS AND METHODS: This crossover clinical trial study was done in Iran on 168 single girl students 18-26 years old in Babol University of Medical Sciences with primary menstrual pain. The participants were randomly allocated to two groups receiving the drugs Novafen and Ginger. At the beginning of pain, in the two groups 200 mg capsule was given every 6 h for two serial cycles. Pain severity was measured by the visual scale before treatment, 1 h after consuming the drug (for 24 h) and 48 h after the onset of drug.RESULTS: The mean age of participants was 21.83  2.07 years. It has been reported that the intensity of pain from dysmenorrhea decreased in the Novafen and Ginger groups. Before treatment, the average pain intensity in Novafen and Ginger users were 7.12  2.32 and 7.60  1.84, respectively and after treatment pain intensity decreased to 3.10  2.69 and 2.97  2.69, respectively. Differences between two groups each time showed no statistical significance (p > 0.05).CONCLUSION: Both drugs reduced menstrual pain. Ginger as well as Novafen is effective in relieving pain in girls with primary dysmenorrhea . Therefore, treatment with natural herbal medicine, non-synthetic drug, to reduce primary dysmenorrhea is recommended.

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Ginger decreases the negative metabolic consequences induced by high-refined carbohydrate diet. "IndyWatch Feed Health"

PMID:  J Med Food. 2018 Oct 26. Epub 2018 Oct 26. PMID: 30362875 Abstract Title:  Ginger (Zingiber officinale Rosc.) Ameliorated Metabolic and Inflammatory Dysfunction Induced by High-Refined Carbohydrate-Containing Diet in Mice. Abstract:  This study aimed to evaluate the effects and the mechanisms of ginger extract intake in the adiposity gain, metabolic and inflammatory disturbances induced by a high-refined carbohydrate (HC) diet in mice. Ginger extract at doses of 200, 600, and 1800mg/kg was supplemented in the daily food of obese Balb/c mice during an 8-week experiment. Our findings indicate that consumption of high doses of ginger extracts prevents the increase of adiposity induced by HC diet, improves lipid profile, and promotes decrease of inflammatory markers in mice.We showed that ginger addition to HC diet leads to decrease in the recruitment of cells visualized in vivo in the microvasculature of adipose tissue, decrease of inflammatory cytokines, and increase of adiponectin serum levels. These results indicate that the consumption of ginger decreases the negative metabolic consequences induced by HC diet.

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10-gingerol affects multiple metastatic processes and induces apoptosis in MDA-MB-231 breast tumor cells. "IndyWatch Feed Health"

PMID:  Anticancer Agents Med Chem. 2018 10 29. Epub 2018 Oct 29. PMID: 30370858 Abstract Title:  [10]-Gingerol Affects Multiple Metastatic Processes and Induces Apoptosis in MDA-MB-231 Breast Tumor Cells. Abstract:  BACKGROUND: Triple negative breast cancer (TNBC) represents the approximately 15% of breast cancers that lack expression of estrogen (ER) and progesterone receptors (PR) and do not exhibit amplification of the human epidermal growth factor receptor 2 (HER2) gene, imposing difficulties to treatment. Interactions between tumor cells and their microenvironment facilitate tumor cell invasion in surrounding tissues, intravasation through newly formed vessels, and dissemination to form metastasis. To treat metastasis from breast and many other cancer types, chemotherapy is one of the most extensively used methods. However, its efficacy and safety remain a primary concern, as well as its toxicity and other side effects. Thus, there is increasing interest in natural antitumor agents. In a previous work, we have demonstrated that [10]-gingerol is able to revert malignant phenotype in breast cancer cells in 3D culture and, moreover, to inhibit the dissemination of TNBC to multiple organs including to lung, bone and brain, in spontaneous and experimental in vivo metastasis assays in mouse model.OBJECTIVES: This work aims to investigate the in vitro effects of [10]-gingerol, using human MDA-MB-231TNBC cells, in comparison to non-tumor MCF-10A breast cells, in order to understand the antitumor and anti-metastatic effects found in vivo and in a 3D environment.METHODS: We investigated different steps of the metastatic process in vitro, such as cell migration, invasion, adhesion and MMP activity. In addition, we analyzed the anti-apoptotic and genotoxic effects of [10]-gingerol using PE-Annexin, DNA fragmentation, TUNEL and comet assays, respectively.RESULTS: [10]-gingerol was able to inhibit cell adhesion, migration, invasion and apoptosis more effectively in TNBC cells, when compared to non-tumor cells, demonstrating that these mechanisms can be involved in the anti-tumor and anti-metastatic effects of [10]-gingerol, found both in 3D culture and in vivo.CONCLUSION: Taken together, results found here are complementary to previous studies of group and others and demonstrate that additional mechanisms, besides apoptotic cell death, is used by [10]-gingerol to accomplish its antitumor and antimetastatic effects. Our results indicate a potential for this natural compound as an antitumor molecule or as an adjuvant for chemotherapeutics already used in the clinic.

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6-gingerol ameliorates age-related hepatic steatosis "IndyWatch Feed Health"

PMID:  Toxicol Appl Pharmacol. 2019 Jan 1 ;362:125-135. Epub 2018 Nov 5. PMID: 30408433 Abstract Title:  6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. Abstract:  The prevalence of NAFLD increases with age. As the main active ingredient of ginger, 6-gingerol significantly improves lipid metabolism abnormalities in adult rodents. However, few studies have reported its effect on age-related NAFLD. This study was to investigate the effects of 6-gingerol on age-related hepatic steatosis and its potential targets. As expected, 6-gingerol dramatically normalized the hepatic triglyceride content, plasma insulin and HOMA-IR index of ageing rats. Mechanistically, 6-gingerol affected lipid metabolism by increasing-oxidation and decreasing lipogenesis through activation of PPAR and CPT1 and inhibition of DGAT-2. Furthermore, 6-gingerol reversed the decreases in citrate, Cs and ATP, lessened the damage caused by ROS, and upregulated mitochondrial marker enzymes NOX, SDH, and SIRT3 in the ageing liver, indicating its ability to strengthen mitochondrial function. Our results showed 6-gingerol exerted a positive effect on insulin sensitivity by regulating Akt. In conclusion, the hepatic anti-steatotic effect of 6-gingerol is associated with inhibition of de novo lipogenesis, upregulation of fatty acidoxidation, reduction in oxidative stress and synergistic enhancement of mitochondrial function.

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6-gingerol ameliorates age-related hepatic steatosis. "IndyWatch Feed Health"

PMID:  Toxicol Appl Pharmacol. 2019 Jan 1 ;362:125-135. Epub 2018 Nov 5. PMID: 30408433 Abstract Title:  6-gingerol ameliorates age-related hepatic steatosis: Association with regulating lipogenesis, fatty acid oxidation, oxidative stress and mitochondrial dysfunction. Abstract:  The prevalence of NAFLD increases with age. As the main active ingredient of ginger, 6-gingerol significantly improves lipid metabolism abnormalities in adult rodents. However, few studies have reported its effect on age-related NAFLD. This study was to investigate the effects of 6-gingerol on age-related hepatic steatosis and its potential targets. As expected, 6-gingerol dramatically normalized the hepatic triglyceride content, plasma insulin and HOMA-IR index of ageing rats. Mechanistically, 6-gingerol affected lipid metabolism by increasing-oxidation and decreasing lipogenesis through activation of PPAR and CPT1 and inhibition of DGAT-2. Furthermore, 6-gingerol reversed the decreases in citrate, Cs and ATP, lessened the damage caused by ROS, and upregulated mitochondrial marker enzymes NOX, SDH, and SIRT3 in the ageing liver, indicating its ability to strengthen mitochondrial function. Our results showed 6-gingerol exerted a positive effect on insulin sensitivity by regulating Akt. In conclusion, the hepatic anti-steatotic effect of 6-gingerol is associated with inhibition of de novo lipogenesis, upregulation of fatty acidoxidation, reduction in oxidative stress and synergistic enhancement of mitochondrial function.

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Dr Ron Unfiltered Uncensored Interview with Dr Jaffe "IndyWatch Feed Health"

Merry Christmas and Happy Holidays. We are bringing you a rerun of one of our classic programs to extend you life.


6-gingerol protects heart by suppressing myocardial ischemia/reperfusion induced inflammation. "IndyWatch Feed Health"

PMID:  Evid Based Complement Alternat Med. 2018 ;2018:6209679. Epub 2018 Nov 5. PMID: 30519268 Abstract Title:  6-Gingerol Protects Heart by Suppressing Myocardial Ischemia/Reperfusion Induced Inflammation via the PI3K/Akt-Dependent Mechanism in Rats. Abstract:  Our previous study has demonstrated that 6-Gingerol (6-G) could alleviate myocardial ischemia/reperfusion injury (MIRI). However, the molecular mechanism underlying the process of myocardial ischemia/reperfusion (I/R) injury alleviation by 6-G remains unelucidated. The objective of the present study is to further investigate the potential mechanism for 6-G to alleviate MIRI in rats. Thirty-two Sprague-Dawley rats were randomly divided into four groups: the Sham group, the I/R group, the 6-G + I/R group, and the LY294002 (LY) + 6-G + I/R group. For the rats in each of the groups, data were collected for cardiogram, cardiac function, area of myocardial infarction, myocardial pathology, myocardial enzyme, marker of inflammatory response, and PI3K/Akt signaling pathway. We found that the pretreatment of 6-G with 6mg/kg could shrink the ST section of cardiogram, improve the cardiac function, reduce the area of myocardial infarction and the degree of cardiac pathological injury, lower the level of myocardial enzyme, and inhibit the inflammatory response. In addition, our results also indicated that 6-G could upregulate the expression of PI3K and p-Akt and that LY294002, a blocking agent of PI3K/Akt signaling pathway, could nullify the protecting role of 6-G. Our experimental results showed that 6-G could inhibit I/R-induced inflammatory response through the activation of the PI3K/Akt signaling pathway.

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Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats. "IndyWatch Feed Health"

PMID:  Chem Biol Interact. 2018 Mar 25 ;284:90-100. Epub 2018 Feb 3. PMID: 29409856 Abstract Title:  Crocin mediated amelioration of oxidative burden and inflammatory cascade suppresses diabetic nephropathy progression in diabetic rats. Abstract:  Diabetic Nephropathy (DN) is one of the main complications associated with diabetes mellitus. Persistently elevated blood glucose level drives histopathological changes in renal tissues that hinder normal kidney functions. In the current study, crocin; the main bioactive constituent of Crocus sativus was investigated as a reno-protective agent against DN by virtue of its numerous pharmacological activities. Diabetes was induced in male Sprague-Dawely rats through intravenous injection of streptozocin (STZ) (50mg/kg), DN was confirmed eight weeks post diabetes induction. Daily oral crocin for eight weeks (20mg/kg) significantly reduced blood glucose level with a significant increase in insulin level. Moreover, crocin improved impaired kidney functions as manifested in reduction of serum creatinine levels, blood urea nitrogen and proteinuria with concomitant increase in urinary creatinine clearance. Furthermore, biomarkers of cell injury and tissue necrosis like LDH activity was significantly reduced, kidney content of NOS significantly declined likewise. In addition, renal antioxidants such asSOD, GSH and serum catalase activity significantly increased with concomitant reduction of kidney MDA; biomarker of oxidative load. Kidney content of toll-like receptors 4 and IL-6 significantly declined with simultaneous suppression of nuclear factor kappa-B (NF-B/p65) protein expression and immuno-staining in rat renal cortex. Furthermore, crocin inhibited progression of renal fibrosis as seen with reduction of renal hydroxyproline and collagen content, TGF- immuno-staining and Masson's Trichrome positive tissue. Histopathologically, crocin pretreatment was associated with minimal renaldamage with fewer fibrotic lesions. There was a concomitant restoration of renal tubules integrity with preservation of glomerular space area. In conclusion, crocin's ameliorative impact on DN may be attributed to its free radicals scavenging properties, its ability to enhance host antioxidant defense system and its ability to inhibit inflammatory and fibrotic cascades activation.

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6-shogaol may be of value in protection against diabetic complications in kidney and heart. "IndyWatch Feed Health"

PMID:  Pak J Pharm Sci. 2018 Sep ;31(5(Supplementary)):2109-2117. PMID: 30393220 Abstract Title:  6-shogaol protects against diabetic nephropathy and cardiomyopathy via modulation of oxidative stress/NF-B pathway. Abstract:  Diabetes dramatically increases the risk of numerous heart and kidney troubles. Diabetic nephropathy (DN) and cardiomyopathy (DC) are major causes of death. The pathophysiology of DN/DC includes inflammatory and oxidative stress mechanisms. NF-B is one of the transcription factor that mediates signal transduction processes. Nowadays, it is suggested that inhibition of NF-B activation could delay the development of DN and DC. 6-shogaol was reported to modulate NF-B besides its anti-oxidant and anti-inflammatory activities. Therefore,it is worth testing it against diabetic complications. Rats were divided to 4 groups: Normal control (NC), 6-shogaol (6S), diabetic control (DC), diabetic rats treated with 6-shogaol (DC+6S). BGL, BUN, serum creatinine, total urine protein, creatine kinase (CK), LDH, NO, TNF- NF-B were determined in serum. Heart and kidney tissues were isolated for GSH, MDA, SOD measurement and histopathology. NF-B was estimated in kidney tissues using immunohistopathology and western blot techniques. Results showed that diabetic rats left untreated for 16 weeks showed kidney injury as evidenced from elevated BUN, serum creatinine, urine protein, TNF- and NF-B. Heart tissue damage was evidence from elevated CK, LDH. Diabetic rats simultaneously treated with 6-shogaol showed a protective effect on both kidney and heart as evidenced biochemically and histopathologically. Therefore, using 6-shogaol may be of value in protection against diabetic complications in kidney and heart of rats.

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6-Shogaol reduces progression of experimental endometriosis. "IndyWatch Feed Health"

PMID:  Korean J Physiol Pharmacol. 2018 Nov ;22(6):627-636. Epub 2018 Oct 25. PMID: 30402023 Abstract Title:  6-Shogaol reduces progression of experimental endometriosisandregulation of VGEF and inhibition of COX-2 and PGE2-mediated inflammatory responses. Abstract:  Endometriosis (EM) is one of the most common gynaecological disorder affecting women in their reproductive age. Mechanisms involved in the pathogenesis of EM remains poorly understood, however inflammatory responses have been reported to be significantly involved. The efficacy of 6-shogaol on proliferation of endometriotic lesions and inflammatory pathways in experimentally-induced EM model was explored in this study. EM was stimulated in Sprague-Dawley rats by implantation of autologous endometrium onto the peritoneum abdominal wall. Separate groups were treated with 6-shogaol (50, 100 or 150 mg/kg b.wt/day) via oral gavage for one month period. Gestrinone (GTN) group received GTN (0.5 mg/kg/day) as positive control. Five weeks after implantation, the spherical volume of ecto-uterine tissues was determined. Treatment with 6-shogaol significantly reduced the implant size. Histological analysis reported atrophy and regression of the lesions. 6-shogaol administration effectively down-regulated NF-B signaling, VEGF and VEGFR-2 (Flk-1) expression in the endometriotic lesions. Excess production of IL-1 and IL-6 (pro-inflammatory cytokines), PGE2 and nitric oxide (NO) were reduced. Overall, the results of the study reveal the efficacy of 6-shogaol against endometriosis via effectively suppressing proliferation of the lesions and modulating angiogenesis and COX-2/NF-B-mediated inflammatory cascades.

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What is Krill Oil? Is it a Better Choice than Fish or Cod Liver Oil? "IndyWatch Feed Health"

krill oil and cod liver oilEvery ocean on planet Earth contains an abundance of tiny animals known as krill. Measuring only about two inches in size, they are uniquely positioned at the base of the food chain along with other organisms such as zooplankton, sardines and minnows.

Thousands of diverse animal species rely on krill for food including birds,

The post What is Krill Oil? Is it a Better Choice than Fish or Cod Liver Oil? appeared first on The Healthy Home Economist.


6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. "IndyWatch Feed Health"

PMID:  Int J Mol Med. 2018 Nov 21. Epub 2018 Nov 21. PMID: 30483736 Abstract Title:  Attenuation of autophagy flux by 6-shogaol sensitizes human liver cancer cells to TRAIL-induced apoptosis via p53 and ROS. Abstract:  Tumor necrosis factor (TNF)related apoptosisinducing ligand (TRAIL) is a member of the TNF superfamily and is an antitumor drug that induces apoptosis in tumor cells with minimal or no effects on normal cells. Here, it is demonstrated that 6shogaol (6sho), a bioactive component of ginger, exerted antiinflammatory and anticancer properties, attenuated tumor cell propagation and induced TRAILmediated cell death in liver cancer cells. The current study identified a potential pathway by revealing that TRAIL and 6sho or chloroquine acted together to trigger reactive oxygen species (ROS) production, to upregulate tumorsuppressor protein 53 (p53) expression and to change the mitochondrial transmembrane potential (MTP). Treatment with NacetylLcysteine reversed these effects, restoring the MTP and attenuated ROS production and p53 expression. Interestingly, treatment with 6sho increasedp62 and microtubuleassociated proteins 1A/1B light chain 3BII levels, indicating an inhibited autophagy flux. In conclusion, attenuation of 6shoinduced autophagy flux sensitized cells to TRAILinduced apoptosis via p53 and ROS, suggesting that the administration of TRAIL in combinationwith 6sho may be a suitable therapeutic method for the treatment of TRAILresistant Huh7 liver cells.

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The Guardian: Snopes paid to push Propaganda by Facebook, former editor reveals "IndyWatch Feed Health"

According to Snopes former managing editor Brooke Binkowski (who was fired for reasons unknown to her, apparently), Facebook pays Snopes to push certain propaganda. (She said at one point, it seemed as if Facebook was pushing reporters to prioritize debunking misinformation that affected Facebook advertisers- something they disputed after the Guardian piece went to print.) And []

The post The Guardian: Snopes paid to push Propaganda by Facebook, former editor reveals appeared first on Health Nut News.


Curcumin inhibits the growth via Wnt/-catenin pathway in non-small-cell lung cancer cells. "IndyWatch Feed Health"

PMID:  Eur Rev Med Pharmacol Sci. 2018 Nov ;22(21):7492-7499. PMID: 30468498 Abstract Title:  Curcumin inhibits the growth via Wnt/-catenin pathway in non-small-cell lung cancer cells. Abstract:  OBJECTIVE: In recent decades, the death rate from lung cancer appears to be an increasing yearly trend, particularly for non-small-cell lung cancer (NSCLC). Curcumin is a yellow pigment found in turmeric rhizomes, reported to exhibit various anti-inflammatory, anti-angiogenic, anti-proliferative, and antioxidant properties. Many reports have suggested that curcumin could induce apoptosis in malignant cells, and therefore, has great potential in tumor treatment. However, little is known about the effect of curcumin on NSCLC or its associated mode of action. Therefore, in this study, we explored curcumin's effect on NSCLC and investigated its associated mechanism.MATERIALS AND METHODS: The non-small-cell lung cancer (NSCLC) cell line A549 was cultured and subjected to MTT and clonogenic survival assays to assess cell proliferation. Reactive oxygen species (ROS) levels were measured using a Fluostar Omega Spectrofluorimeter. Superoxide dismutase (SOD) and-glutamyl cysteine synthetase (-GCS) activity in A549 cells were both determined by a commercial determination kit. Expression levels of p-GSK3 (Ser9), c-Myc, cyclin D1, -catenin -tubulin, and proliferating cell nuclear antigen (PCNA) were analyzed by Western blot.RESULTS: Results of the MTT and clonogenic survival assay indicated that curcumin reduced A549 proliferation. ROS levels and SOD and-GCS activities were detected. Curcumin decreased intracellular ROS levels and increased SOD and -GCS activity. Meanwhile, the ROS inhibitor N-Acetylcysteine (NAC) reversed the decrease in ROS levels and the increase in SOD and -GCS activity. These results indicate that oxidative stress is involved in the curcumin-induced reduction of A549 viability. Curcumin also strongly inhibited -catenin and p-GSK3 (Ser9) protein expression, as well as the expression of downstream cyclin D1 and c-Myc. Similarly, NAC reversed the inhibition of -catenin and p-GSK3 (Ser9) protein expression, aswell as the expression of downstream cyclin D1 and c-Myc.CONCLUSIONS: We showed that curcumin inhibits NSCLC proliferation via the Wnt/-catenin pathway.

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Thymoquinone and NAC attenuate uranyl acetate adverse effects on the testicular microenvironement. "IndyWatch Feed Health"

PMID:  Gen Physiol Biophys. 2018 Dec 14. Epub 2018 Dec 14. PMID: 30547892 Abstract Title:  Uranium exposure increases spermatocytes metaphase apoptosis in rats: inhibitory effect of thymoquinone and N-acetylcysteine. Abstract:  Uranyl acetate (UA), a commercial stock from depleted uranium (DU), has a combined effect of chemical toxicity and mild radioactivity. Here, we investigated the potential antioxidant, antiapoptotic and cytoprotective effects of thymoquinone (TQ) and N-acetylcysteine (NAC) against UA-induced testicular damage in rats. UA reduced testicular superoxide dismutase (SOD) activity and nitric oxide (NO) and glutathione (GSH) levels relative to the control group. Interestingly, the testicular SOD activity and NO and GSH levels of UA/TQ- and UA/NAC-treated groups were also significantly lower relative to the control. A marked increase in spermatocytes metaphase apoptosis was found (stage XIII) in UA-treated rats, which is probably due to difficulties in segregation of homologous-chromosomes. This may clarify why UA exposure decreased round spermatids numbers and fertility in previous studies. To check the reason of partial metaphase arrest, the presence of DNA-damage-related-H2AX foci in late spermatocytes of all groups was checked, but only insignificant increase was found in UA-treated group. TQ or NAC supplementation reduced the apoptosis and improved the testicular histological alterations. Thus, TQ and NAC attenuate UA adverse effects on the testicular microenvironement through anti-apoptotic and cytoprotective but not antioxidant effects.

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Beef, Sausage, & Corn Recalled But Dont Worry, Says the FDA "IndyWatch Feed Health"

By Daisy Luther

I cant be the only one wondering what the heck is going on with our food system lately. The recalls on commonly consumed foods have been so numerous that it seems like theres another one every other day.

The contamination of our food supply is very unsettling. This year hundreds of people were sickened by romaine lettuce contaminated with E. coli and several even died. But there have also been recalls on meat, on breakfast cereal, on frozen food, and even pet food.

In just the past week, there have been massive recalls on ground beef, breakfast sausage, and canned corn. Below, youll find the details. Check your kitchen and dispose of any of these foods if you have them on hand.

12 Million Pounds of Ground Beef Recalled

JBS Tolleson Inc. has expanded their recall of ground beef and non-intact beef products to include 12 million pounds of meat. The products are feared to be contaminated with salmonella.

Because these were packaged between July 26, 2018, to Sept. 7, 2018, the most likely destination for these products would be your freezer. The products recalled include ground beef chubs, burger patties, ground beef sold in trays, and pre-seasoned ground beef.



What Do Twin Studies Prove About Genetic Influences on Psychiatric Disorders? Absolutely Nothing "IndyWatch Feed Health"

I write frequently about the fallacies of behavioral twin research, in both its reared-together and reared-apart forms. I am compelled to keep doing this because twin studies of behavior, and the claims based on them, have not gone away despite decades of critics airtight arguments that indicate that they should have gone away a long time ago. Assessing the validity of psychiatric twin research is very important because it relates directly to the question of whether the main causes of psychological distress and dysfunction, and socially disapproved behavior, are located inside of the human body and brain, as mainstream psychiatry claims, or outside of the body and brain, as many critics argue. Twin studies are often cited in support of psychiatrys disputed claim that its diagnoses are valid medical/biological conditions caused by a brain malfunction or by a chemical imbalance.

I recently published an online in-depth critical analysis of the famous Minnesota Study of Twins Reared Apart (MISTRA), where I concluded that because this reared-apart twin study was unable to disentangle (separate) the potential influences of genes and environments on human behavior, in addition to many other reasons, the researchers conclusions in favor of important genetic influences on IQ, personality, and other behavioral characteristics must be rejected. This conclusion applies to all other published twins reared apart studies as well. Other than some individual cases of MZ pairs that have come to the attention of researchers since the 1920s, the only reared-apart twin study that looked into areas related to psychiatry was a 1990 MISTRA study of substance abuse/dependence and antisocial personality.

Twin studies of the major psychiatric disorders have been based on pairs who were reared together in the same family home. Since 1998 I have written about the many problems with these studies, which nevertheless form the bedrock of genetic theories and claims in psychiatry. Here I will highlight and examine the main underlying fallacy of psychiatric twin studies, and of twin studies of behavior in general. It is now widely understood that psychiatric family studies are unable t...


Protective effect of N-acetylcysteine on dizocilpine-induced testicular oxidative stress in mice. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2019 Jan ;109:1988-1993. Epub 2018 Nov 26. PMID: 30551454 Abstract Title:  Protective effect of N-acetylcysteine on MK-801-induced testicular oxidative stress in mice. Abstract:  Experimental studies indicate that MK-801 causes organ injury in schizophrenic mice testes although it is molecular mechanism has not been clearly defined. In this study, we investigated the probable protective effect of N-Acetylcysteine (NAC) against MK-801- induced testicular toxicity in mice. In total, 24 Balb/C male mice were divided into 4 equal groups: the animals in the control group (vehicle treated) were intraperitoneally given 10mL/kg/day saline solution, the animals in the experiment groups were intraperitoneally given 1mg/kg/day MK-801 alone, 100mg/kg/day NAC alone and MK-801 by 1mg/kg/day for 14 days. The level of the testes' total oxidant status (TOS) in mice that were treated with MK-801 was significantly higher than those level in the other groups while the total antioxidant status (TAS) levels decreased. In comparison to the MK-801 group, the TOS levels were lower, and the TAS levels increased in the MK-801 + NAC group. In the morphometric analysis, the diameter and epithelial height of the seminiferous tubules of the testes showed no significant changes after MK-801 administration. Conversely, the weights of the testes decreased significantly. In the treatment with NAC, the weights of testes significantly increased in comparison to the MK-801 group. The histopathological examination revealednecrobiotic and degenerative changes in the epithelial cells, vacuole formation within the seminiferous tubules, a decrease in the number of the spermatozoid, and disorganization in the basement membrane of the seminiferous tubules in the MK-801 group in comparison to the control group. Administration of NAC alleviated several negative effects of MK-801 on the testicular damage in mice. In conclusion, our results showed that NAC protected the mice against the testicular toxicity of MK-801 when it was administrated intraperitoneally.

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N-acetylcysteine could be associated with a reduction in depressive symptoms. "IndyWatch Feed Health"

PMID:  J Clin Psychiatry. 2018 Dec 4 ;80(1). Epub 2018 Dec 4. PMID: 30549489 Abstract Title:  A Double-Blind, Randomized, Placebo-Controlled Study of Aspirin and N-Acetylcysteine as Adjunctive Treatments for Bipolar Depression. Abstract:  OBJECTIVE: Neuroinflammation has been implicated in the pathophysiology of bipolar disorder. Some evidence shows that nonsteroidal anti-inflammatory drugs (NSAIDs) have promising antidepressant effects. The antioxidant N-acetylcysteine (NAC) may enhance the effects of NSAIDs. No study has, however, tested the adjunctive therapeutic benefits of an NSAID and NAC in bipolar disorder.METHODS: The sample included 24 medicated patients diagnosed with DSM-IV-TR bipolar disorder who were aged 18-65 years and had a Montgomery-Asberg Depression Rating Scale (MADRS) score 20. Participants were randomly assigned to receive either aspirin (1,000 mg), NAC (1,000 mg), combined aspirin and NAC (1,000 mg each), or placebo. Data were collected between 2013 and 2017. The primary outcome was a 50% reduction in MADRS scores. Participants completed mood and global functioning questionnaires. They also underwent blood tests prior to and following 8 and 16 weeks of treatment. A Bayesian analytic method was adopted, and posterior probability distributions were calculated to determine the probability of treatment response.RESULTS: Following the first 8-week treatment phase, individuals on treatment with placebo and NAC + aspirin had a similar probability for successful treatment response (about 70%). Following a 16-week treatment period, NAC + aspirin was associated with higher probability of treatment response (67%) compared to placebo (55%), NAC (57%), and aspirin (33%). There was no treatment effect on interleukin-6 and C-reactive protein levels at either 8 or 16 weeks.CONCLUSIONS: The coadministration of NAC and aspirin during a period of 16 weeks was associated with a reduction in depressive symptoms. The adverse effects were minimal. These preliminary findings may serve as a starting point for future studies assessing the efficacy, tolerability, and safety of anti-inflammatory and antioxidant agents in the treatment of bipolar depression.TRIAL REGISTRATION: identifier: NCT01797575.

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Overview on the effects of N-acetylcysteine in neurodegenerative diseases. "IndyWatch Feed Health"

PMID:  Molecules. 2018 Dec 13 ;23(12). Epub 2018 Dec 13. PMID: 30551603 Abstract Title:  Overview on the Effects of-Acetylcysteine in Neurodegenerative Diseases. Abstract:  -acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson's and Alzheimer's disorders and in neuropathic pain and stroke.

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NPR: Baby, Its Cold Outside, seen as sexist, frozen out by radio stations "IndyWatch Feed Health"

By now, you have heard about the controversy surrounding the song, Baby, its cold outside or you live under a rock. Written by Frank Loesser in 1944, Baby, Its Cold Outside was featured in the 1949 film Neptunes Daughter, and even won the Oscar for best original song.1 Check it out below: While some radio stations []

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Do not buy chicken with this brand on the label "IndyWatch Feed Health"

Theres overwhelming evidence showing that antibiotic use in livestock is driving the rise in antibiotic resistance, and many poultry producers including Tyson Foods, Perdue and Pilgrims Pride have taken steps to curb antibiotic use in their live poultry production. In recent years, a number of grocery and restaurant chains have also vowed to []

The post Do not buy chicken with this brand on the label appeared first on Health Nut News.


Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress. "IndyWatch Feed Health"

PMID:  J Nutr Biochem. 2018 Dec ;62:221-229. Epub 2018 Sep 1. PMID: 30312797 Abstract Title:  Fisetin inhibits cardiac hypertrophy by suppressing oxidative stress. Abstract:  Cardiac hypertrophy is a pathophysiological response to various pathological stresses and ultimately leads to heart failure. Oxidative stress is one of the critical processes involved in hypertrophy development. Fisetin, a small molecular flavonoid, has been shown to have anti-oxidative, anti-proliferative and anti-inflammatory properties. However, the effect of fisetin on cardiac hypertrophy remains unknown. In our present study, we showed that fisetin inhibited pressure overload-induced cardiac hypertrophy, improved cardiac function in vivo and suppressed phenylephrine (PE)-induced cardiomyocyte hypertrophy in vitro. Reactive oxygen species (ROS) levels were markedly decreased by fisetin treatment in both hypertrophic hearts and cardiomyocytes. Moreover, fisetin significantly up-regulated the expression of antioxidative genes, including catalase (CAT), superoxide dismutase 1 (SOD1) and heme oxygenase 1 (HO-1). Furthermore, co-treatment with N-acetylcysteine (NAC; ROS scavenger) and fisetin did not have synergistic inhibitory effects on PE-induced cardiomyocyte hypertrophy, indicating that the anti-hypertrophic effects of fisetin are mainly associated with the blockade of oxidative stress. Finally, the pro-hypertrophic signaling pathways, mitogen-activated protein kinase (MAPK) and mammalian target of rapamycin (mTOR) kinase, were found to be suppressed by fisetin after pressure overload and PE treatment. In conclusion, our study revealed that fisetin protects against cardiac hypertrophy and that oxidative stress inhibition may be one of the pivotal mechanisms involved.

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Windsor to put fluoride back into the water after council vote "IndyWatch Feed Health"

After a five-year moratorium, Windsor will be seeing fluoride in the water again.

City council voted 8-3 in favour of the reintroduction of fluoride. Back in 2013, council voted 8-3 to take it out after more than 50 years of water fluoridation.

The issue was a controversial one with 16 delegates lined up to speak, and 59 emails received by the city clerk ahead of the meeting. The debate went on for hours.

One of the delegates was Dr. Wajid Ahmed, acting medical officer of health with the Windsor-Essex County Health Unit. According to the Oral Health 2018 report released by the health unit, the percentage of children with tooth decay or requiring urgent care has increased by 51 per cent in 2016-17 compared to 2011-12.

However, Mayor Drew Dilkens, who voted to have fluoride taken out five years ago did not change his stance. He joined Ward 1 Coun. Fred Francis and Ward 5 Coun. Ed Sleiman in casting dissenting votes.

Fluoride is one tool for good oral health, we all know that, but its not the only tool, Dilkens said before the meeting.

Dilkens said fluoridated toothpaste is the number-one thing people can use to protect their teeth. He also suggested Healthy Smiles, the provincial program for low-income families to send their kids to receive free dental care.

However, Joyce Zuk, executive director of Family Services Windsor-Essex doesnt agree that toothpaste is enough.

She said requests for dental assistance at the organization have gone up by 300 per cen*t from 2014 to 2018.

Im not trained in science, said Zuk. When we dont know the answer, we look to our experts to provide us with an answer. And in this case, our experts are the Windsor-Essex County Health Unit.

Ward 6 Coun. Jo-Anne Gignac, who voted against taking fluoride out five years ago, kept her stance this time. She said even though water fluoridation is not a silver bullet in solving dental problems in the community, its going to go a heck of a long way.

Mixed reviews

Some delegates wrote that they dont want fluoride in their water because they are worried about potential adverse health effects, while others want to have a choice for what...


The antiadipogenic properties of piceatanol could be used in the treatment of the metabolic complications associated with obesity. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2018 Jul 17 ;19(7). Epub 2018 Jul 17. PMID: 30018277 Abstract Title:  The Dietary Antioxidant Piceatannol Inhibits Adipogenesis of Human Adipose Mesenchymal Stem Cells and Limits Glucose Transport and Lipogenic Activities in Adipocytes. Abstract:  Phenolic compounds are among the most investigated herbal remedies, as is especially the case for resveratrol. Many reports have shown its anti-aging properties and the ability to reduce obesity and diabetes induced by high-fat diet in mice. However, such beneficial effects hardly translate from animal models to humans. The scientific community has therefore tested whether other plant phenolic compounds may surpass the effects of resveratrol. In this regard, it has been reported that piceatannol reproduces in rodents the anti-obesity actions of its parent polyphenol. However, the capacity of piceatannol to inhibit adipocyte differentiation in humans has not been characterized so far. Here, we investigated whether piceatannol was antiadipogenic and antilipogenic in human preadipocytes. Human mesenchymal stem cells (hMSC), isolated from adipose tissues of lean and obese individuals, were differentiated into mature adipocytes with or without piceatannol, and their functions were explored. FiftyM of piceatannol deeply limited synthesis/accumulation of lipids in both murine and hMSC-derived adipocytes. Interestingly, this phenomenon occurred irrespective of being added at the earlier or later stages of adipocyte differentiation. Moreover, piceatannol lowered glucose transport into adipocytes and decreased the expression of key elements of the lipogenic pathway (PPAR, FAS, and GLUT4). Thus, the confirmation of the antiadipogenic properties of piceatanol in vitro warrants the realization of clinical studies for the application of this compound in the treatment of the metabolic complications associated with obesity.

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Business Insider: Erin Brockovich is warning about an emerging drinking-water crisis in the US. Heres how she recommends you protect yourself. "IndyWatch Feed Health"

(Note from Erin: We are proud to be endorsing the same water system as Erin, the Click on the link for more info and a great deal on the price.) Erin Brockovich, who some of you know as the woman who fought against Californias Pacific Gas and Electric (PG&E) in 1996 and later had a movie []

The post Business Insider: Erin Brockovich is warning about an emerging drinking-water crisis in the US. Heres how she recommends you protect yourself. appeared first on Health Nut News.



Strophanthin / Ouabain is the most powerful natural heart attack prevention remedy known to man. In our newest video we have


One Step Closer: The Legal Expansion of Industrial Hemp "IndyWatch Feed Health"

By Susan Boskey

Let it be known that the cultivation of industrial hemp, a non-psychoactive variety of cannabis, is now possible for every state of these United States. This, with the passing of the Unified 2018 Farm Bill, December 2018, championed by Senate Majority Leader Mitch McConnell (R-Ky.). The Bill is said to have been signed with a pen made from hemp.

The summary for Title X Horticulture under subheading, Other Provisions reads:

Hemp Production: Amends the Agricultural Marketing Act of 1946 [1] to allow states and Indian tribes to regulate or follow a plan established by the Secretary to regulate hemp production that includes locations of hemp production, sample testing for THC concentration, sample inspections of producers, and disposal of plants that are out of compliance.

The welcome news regarding industrial hemp laws does, however, come at the price of heavy regulation.  According to section 10113 of the 2018 Farm Bill, an interested states plan for industrial hemp cultivation must first be run by their governor and top law enforcement official. Once the plan has buy-in from these top officials, it then must be submitted for further approval from the federal Secretary of USDA. In states that do...


Canadian Chiropractor Faces Suspension For Vaccine Posts "IndyWatch Feed Health"

A Canadian chiropractor who made posts online regarding vaccines is facing the suspension of her license. Dena Churchill, who operates Oxford Chiropractic Inc., is currently suspended pending a complete investigation. Churchill has 16 allegations against her...

The post Canadian Chiropractor Faces Suspension For Vaccine Posts appeared first on Vaxxter.


Brazilian spiritual healer John of God, accused of sexually assaulting 450 women, proclaims innocence to tearful devotees "IndyWatch Feed Health"

In case you wondered whether or not the famous Brazilian spiritual healer Joao de Deus or John of God (he shot to fame in 2010 when Oprah Winfrey ran a show on him after having visited him the previous year) was actually a bonafide healer from God, it seems, no: police are currently investigating complaints []

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Cheesecake Factory Honors The Spirit of Christmas for Intellectually Disabled Young Adult "IndyWatch Feed Health"

Cheesecake factoryHi, friends. I thought we could use a feel good story that is more than lip service to those of us who have children with special needs. I'm in a Facebook group for families with children with any sort of disability or diagnosis, from young to adult. We support each other, share ideas, kvetch about the vagaries of life, etc. This week, a Mom posted a great message that I will paraphrase here. The Cheesecake Factory is at the Westfield Mall in Trumbull, CT. The manager is Jamie.

The Cheesecake Factory does not take reservations. This Mom wanted to have her young adult son's birthday party there, at HIS request. When she explained to the manager that a group of about 10 special needs guests would be attending the party, and that they might have a difficult time waiting in the infamous Cheesecake Factory line, the manager instantly made an exception and booked a table for the group.

This seems like such an insignificant gesture. So what? They reserved a table. Bah humbug! You and I know this is a big deal. Each moment of kindness that helps us to help our kids feels like Christmas Day.  

Happy Holidays.  God bless us, Kim


Toddler in China dies day after MMR vaccination "IndyWatch Feed Health"

On November 28th in the Chinese province of Hunan, a two-year-old boy died just one day after being vaccinated with the MMR vaccine at a health center in the city of Changsha (Kaifu district). We are so sorry for his familys loss. Our heart goes out, especially to his mother. I cannot imagine. RELATED STORY: []

The post Toddler in China dies day after MMR vaccination appeared first on Health Nut News.


Neuroscientist: To Fight Opioid Addiction, Tackle Loneliness "IndyWatch Feed Health"

From The Washington Post: Feeling lonely? Social isolation isnt just bad for your mood it can be bad for your health, too. And in a TEDxMidAtlantic talk, Rachel Wurzman says it contributes to opioid addiction fueling drug use, relapses and overdoses.

Wurzman, a neuroscientist, says she thinks there is a way to make recovery from opioid addiction easier: social connection. That idea is informed by her work with the striatum, a region at the base of the forebrain that helps enable decision-making and is dramatically affected by social connection.

Called the brains autopilot, the striatum can also trigger compulsive behaviors, such as repeated drug use. Social isolation leaves the striatum in a hypersensitive state, she says, one in which people are more likely to chase a quick reward. The brain can translate loneliness into literal pain, says Wurzman, and that can have disastrous consequences.

If we dont have the ability to connect socially, we are so ravenous for our social neurochemistry to be rebalanced, were likely to seek relief from anywhere, she says. And if that anywhere is opioid painkillers or heroin, it is going to be a heat-seeking missile for our social reward system.'



More Than a Third of Female Suicides Are Committed by Indian Women "IndyWatch Feed Health"

From Scientific American: The situation may be related to a clash between womens aspirations and the rigidity of their social environment, hypothesizes study author Rakhi Dandona, a professor of global health at the Public Health Foundation of India and the University of Washington. As India has developed, women have become better educated and more empowered, and arranged marriages have declined. Yet in many aspects of society, women still possess lower status and face barriers to opportunity. Dandona and other experts suspect this disconnect may drive some to despair. Suicide rates are especially high in southern Indian states, where development and social advances have accelerated. In contrast, Dandona says, suicide rates in the rural, more traditional northern states could be lower because women there may have less knowledge that they could actually live a better life.

Deaths that occur due to suicide are also a product of the method that is used, says Vikram Patel, a professor of global health at Harvard University, who was not involved in the Lancet Public Health study. In the West, women attempt suicide more often than men, but men typically use more lethal means, resulting in more deaths. In India, however, Patel says that men and women tend to use the same, more fatal, methods.



The waiting game: A university requests a retraction. Then it waits three years. "IndyWatch Feed Health"

On June 25, 2015, following an investigation into the work of a then-graduate student at University College Cork in Ireland, the senior author of a 2014 paper in PLOS ONE requested its retraction. The paper, said senior author Zubair Kabir in an email to Iratxe Puebla, the journals managing editor, was fundamentally flawed. Puebla responded Continue reading The waiting game: A university requests a retraction. Then it waits three years.


Researchers Ask, Why Do Antidepressants Stop Working? "IndyWatch Feed Health"

An international group of researchers, including several with financial ties to manufacturers of antidepressants, explores possible explanations for why long-term users of antidepressants become chronically depressed.

The lead author on the paper is Michele Fornaroa at the University School of Medicine Federico II, Naples, Italy. The article is published online ahead of print in the journal Pharmacological Research. Fornaroas conservative estimate, based on previous literature, is that up to a third of people taking antidepressants find them ineffective or find that they increase depressive symptoms.

Mad in America has previously reported on studies that have found that antidepressant efficacy is overestimated, that antidepressant use is associated with worse outcomes, regardless of initial depression severity, and that severe withdrawal symptoms are common after discontinuationparticularly after long-term use.

Emotional Blunting

Consistent with this research, Fornaroa and the others write that a potential detrimental manifestation of long-term treatment with antidepressants may be the emotional blunting phenomenon or otherwise depressogenic phenomena.

A high proportion of patients receiving SSRIs may exhibit a clinical phenomenon referred to as emotional blunting. Those patients often describe their emotions as being damped-down or toned-down, while some patients refer to a feeling of being in limbo and just not caring about issues that were they once cared about. Such adverse aective manifestations may persist even after the symptoms of depression have improved and may ensue in patients of all ages.

In emotional blunting, people lose the ability to experience their emotions and to self-regulate their emotional state. Thus, in a high proportion of patients, the inability to experience pleasure, joy, and passion may be the cost of numbing ones pain.

Other Tolerance...


The Emperor Has No Clothes "IndyWatch Feed Health"

One would almost think he had nothing on, but that's what makes them so fine.

"Exactly," all the noblemen agreed, though they could see nothing, for there was nothing to see.

The Emperor shivered, for he suspected they were right. But he thought, "This procession has got to go on." So he walked more proudly than ever, as his noblemen held high the train that wasn't there at all.

Thank you Ted for helping to "connect the dots." The theme of the naked emperor is universal when the people refuse to acknowledge an ugly reality, despite what is in front of their very eyes.

By Ted Kuntz

Vaccination is not:

  • Immunization
  • Safe
  • Effective
  • Evidence-based
  • Patient-centric
  • Prevention
  • Health promoting

Vaccination Policy is:

  • based on faith/blind trust
  • industry dominated
  • anti-science
  • coercive and fear based
  • corrupted by conflicts of interest
  • eroding rights and freedoms


  • negatively impact brain development
  • negatively impact immune development
  • contain neurotoxic ingredients
  • contain aborted human fetal cells
  • contain animal cells and viruses
  • contain chemicals, preservatives and foreign matter
  • are not tested for their ability to cause cancer (carcinogenicity)
  • are not tested for impact on fertility
  • are not tested for their ability to damage an organism (toxicity)
  • are not tested for their ability to damage genetic information within a cell (genotoxicity)
  • are not tested for their ability to change the genetic information within an organism (mutagenicity)
  • are not tested for long term effects
  • erode true herd immunity...


19 Foods Proven To Lower Blood Pressure "IndyWatch Feed Health"

19 Foods Proven To Lower Blood Pressure

Hypertension affects about 30% of adults worldwide. While most people try to cut back on salt to lower their pressure, a better strategy may be to add these healthy foods to the menu.   

Hypertension affects about 30% of adults worldwide. Among dietary factors salt has taken the brunt of the blame.  But sugar may be the real culprit in high blood pressure

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Why Almonds Are So Good for You: Health Benefits of Almonds Backed by Science "IndyWatch Feed Health"

Almonds are a delicious nut that are packed with minerals, vitamins, healthy fats, and antioxidants. Almonds come from the Mediterranean, the Middle East, and the Western United States and are very good for you because they are a very nutritious snack. Consuming almonds can help you lose weight, improve your cardiovascular health, and keep your digestion working well.

You can eat almonds with the skin on, blanched (skinless), and roasted. It is usually best to eat almonds without removing the skin because the brown almond skin is full of antioxidants. That means that some of the other health benefits of eating raw almonds include improving the symptoms of diabetes, boosting your immunity, and they have anticancer properties.

In this article, you will find out about the rich nutritional content of almonds and why they are so good for you. You will also learn about recent scientific research that shows why almonds are a delicious healthy nut.

What Are Almonds?

Almonds are actually not true tree nuts they are the seeds of the fruit of the almond tree (called drupe). Almond seeds are surrounded by a hard shell which has to be removed to enjoy the tasty almonds.

Researchers from Harvard Public School of Health say that raw almonds are a nutrition-dense food that have many health benefits. (1)

You can eat raw almonds with the skins still on. However, many people prefer blanching almonds by placing them in some boiling water to help remove their skin. This gives skinless almonds a finer texture that is good for making almond flour.

Almonds, like many other nuts and seeds, contain phytic acid which can inhibit the absorption of important nutrients. One way to remove the phytic acid is to soak the nuts overnight. This means that soaked almonds may have better nutritional content than un-soaked almonds.

As well as eating roasted or raw almonds as a tasty nutritious snack, you can also consume almond milk, almond butter, or almond paste.

Why Almonds Are So Good for You

The reason why almonds are very healthy is that they contain fiber, protein, healthy fats, and important minerals.

Researchers have found that almonds are a healthy snack because they contain high amounts of vitamin E (alpha-tocopherol), magnesium, copper, and other phytonutrients. The healthy fats in almonds are also beneficial if you want to reduce cholesterol. (2)

Scientists also say that almonds can help with weight loss. Even though almonds are an energy-dense food, there is no evidence that consuming almonds dai...


Judge Rules False Advertising Lawsuit Against Sanderson Poultry CAFO Will Proceed "IndyWatch Feed Health"

There's overwhelming evidence showing that antibiotic use in livestock is driving the rise in antibiotic resistance, and many poultry producers including Tyson Foods,1 Perdue2 and Pilgrim's Pride have taken steps to curb antibiotic use in their live poultry production.

In recent years, a number of grocery and restaurant chains have also vowed to stop buying and selling chicken raised with antibiotics. Examples include Whole Foods Market, Chick-fil-A, Chipotle, Panera Bread and even McDonald's.

Six of the largest school districts in the U.S. (New York City, Los Angeles, Chicago, Dallas, Miami-Dade County and Orlando County) have also switched to antibiotic-free chicken in their cafeterias.

In contrast, Sanderson Farms,3 the third-largest poultry producer in the U.S., has stood firm against the tide of calls to reduce antibiotic use, vowing to continue using the drugs in their chickens, going so far as to use it as a selling point,4,5 while simultaneously advertising their chicken as "100% Natural."

A lawsuit filed against the company last year, charging Sanderson Farms with false advertising, is now moving forward. At the same time, Sanderson has announced it will discontinue using antibiotics deemed important for human health for disease prevention purposes in their production a radical change in stance that shows public pressure is paying off.

For Years, Sanderson Farms Has Refused to Yield to Call for Antibiotic-Free Chicken

Remarkably, Sanderson Farms' CEO Joe Sanderson Jr. has actually gone on record saying antibiotics don't cause antibiotic-resistant bacteria, and that the shift away from antibiotics is nothing more than a marketing ploy to justify higher prices.6

Lampkin Butts, president and chief operating officer of Sanderson Farms, has also stated "There is not any credible science that leads us to believe we're causing antibiotic resistance in humans."7 In a 2016 press release, the company said:8

"While Sanderson Farms recognizes that antibiotic resistance is an issue that must be taken seriously, many...


All Civilizations Collapse if They Depend on This "IndyWatch Feed Health"

A society that builds its foundations on annual agriculture cannot survive, according to Mark Shepard, CEO of Forest Agriculture Enterprises and founder of New Forest Farm, a 106-acre perennial agricultural savanna. In the video above, Shepard speaks to organic farmers not only about his farm but also why annual agriculture is doomed from the start.

In short, annuals which include the grain crops and soy that make up most U.S. farmland are chemical intensive and enemies of diversity. Eventually, Shepard says, the destruction caused by this type of shortsighted farming, i.e., annual monocropping, will cause the civilization that depends on it to collapse.

Whats needed, instead, are perennial ecosystems that redesign agriculture in natures image. In other words, as stated by Forest Agriculture Nurserys restoration philosophy:1

Annual monocropping produces nearly all of the grain, meat, vegetables and processed foods consumed today. These practices require giant machinery, tilling and the application of chemical pesticides and fertilizers, resulting in the eradication of biodiversity, the erosion of topsoil, and contributes 30 percent of global carbon emissions more than from any other source.

Despite the massive human efforts applied to farming, we are woefully short of the inherent resilience, stability, and outright beauty of natural ecosystems. We need look no further than native ecosystems for a template of how to move forward from the many woes of annual monocropping.

Whats the Cost of Corn and Other Annual Crops?

Theres now so much corn grown in the U.S. that the Corn Belt (typically said to include corn grown across Indiana, Illinois, Iowa, Missouri and parts of Nebraska and Kansas) can be seen from space, courtesy of satellite chlorophyll-sensors.2 Rather than corn being grown as a food source for humans, the two major consumers of corn are industrial in nature: concentrated animal feeding operations (CAFOs) and ethanol.

The first part of the devastation comes in making room for the vast swatches of monocrops, as valuable prairies are often turned under as a result. Since the early 1800s, grasslands in North America have decreased by 79 percent and in some areas by 99.9 percent.3

Carbon erosion from the land and into th...

Study: Microplastics Were in the Gut of Every Sea Turtle Tested "IndyWatch Feed Health"

Every year, anywhere from 5 million to 12 million tons of plastic debris enter waterways worldwide, which equates to an estimated 5 trillion pieces of plastic.1 While some of this plastic is in the form of large debris like plastic bottles, six-pack rings and bags, much of it is in the form of tiny particles known as microplastics, which are less than 5 millimeters (mm) in size.

Microplastics can come from direct or primary sources, such as microbeads used in cosmetics or fibers used in clothing. They can also be secondary microplastics, meaning theyre the result of larger plastic items that have disintegrated due to exposure to waves, salt water, ultraviolet radiation and physical abrasion against shorelines.

Microplastics do not, unfortunately, simply disappear into the water. Their prevalence and abundance has made them one of the worst polluters in the oceans, with a variety of marine life ingesting the particles, either by intention or happenstance.

Sea Turtles Are Ingesting Microplastics

Research published in Global Change Biology revealed that microplastics are ubiquitous in sea turtles.2 Every turtle tested, which included 102 turtles from all seven marine turtle species from three ocean basins (Atlantic, Mediterranean and Pacific), contained the plastics, at varying levels.

Most abundant were plastic microfibers (most often blue or black in color), but fragments and microbeads were also detected, albeit in lesser quantities. Microfibers come from many sources, including shedding from synthetic fabrics, wear from automotive tires and degradation of cigarette filters and fishing nets and ropes.

Once in the water, turtles may be exposed via contaminated sea water and sediments. In the latter case, many sea turtles are known to feed along the ocean bottom, stirring up and ingesting sediment along with their prey.

They may also be exposed directly via their dietary sources. Microplastics can bind to seaweed electrostatically, for instance, while sponges, another turtle delicacy, also ingest microplastics.

In all, more than 800 particles were found by the researchers,3 but because the featured study only tested a small sample of the turtles gut content residue, its believed that their findings represent only minimum exposure levels to plastics.

The total number of synthetic particles within the whole gut is likely to be the order of...


The Best Scientifically Proven Foods to Cleanse Your Liver "IndyWatch Feed Health"

Foods that are good for your liver help to naturally increase detoxification enzymes that help to cleanse the liver. Liver healthy foods that have a cleansing effect include green tea, citrus fruits, garlic, green leafy vegetables, and nuts. To help improve your liver function, it is also important to consume healthy oils like extra virgin olive oil and omega-3 fatty acids.

Consuming foods that have particular benefits for the liver can help to repair liver damage. These liver-friendly foods help to increase antioxidants in the liver which promote good liver health.

As well as incorporating liver cleansing foods in your diet, you should also avoid certain foods that affect liver function. Some foods that are bad for your liver include alcohol, salt, too much processed sugar, and fatty foods.

In this article, you will learn what scientific research says as to the best foods that are good for your liver. You will also find out how to improve liver function with a liver cleanse.

What Your Liver Does

Your liver is one of the largest organs in your body and is located under in your upper right abdomen. Researchers say that your liver plays an important role in flushing toxic substances from your body. The liver also helps to extract nutrients from food and drinks that we consume. (1)

According to doctors, your liver helps to detoxify any toxins that are in your blood. However, your liver does more. Liver function also includes breaking down fats and metabolizing carbohydrates and proteins. (1)

Ammonia is a toxic substance that is a natural process of metabolic processes. Your liver converts this toxin into a substance called urea that is eventually flushed from your system through your urine. (2)

What is a Liver Cleanse?

There are many foods that help promote good liver health and assist in cleansing toxins from your system.

A liver cleanse is another way of talking about liver-benefiting foods and drinks that help your liver to function properly. Foods that are included in a liver cleanse assist in boosting the number of detoxification enzymes in the liver. These compounds have a hepatoprotective effect; in other words, they promote good liver health, reduce inflammation in the liver, and help keep you healthy.

For a natural liver cleanse to promote good liver health, you should incorporate foods that are good for your liver.

Foods That Are Good f...


Video: Prison Reform and Ruthless Neocons "IndyWatch Feed Health"

Congress is close to approving a bill that promotes prison reform (the First Step Act), to the delight of President Trump, but some authoritarian neocons are vowing to obstruct it. At the same time, President Trump is appointing William Barr as his Attorney General, who is a deplorable choice.

You may watch this on YouTube if there are any problems watching the video at this site.


The antioxidative activity of piceatannol and its different derivatives. "IndyWatch Feed Health"

PMID:  Phytochemistry. 2018 Dec ;156:184-192. Epub 2018 Oct 10. PMID: 30312934 Abstract Title:  The antioxidative activity of piceatannol and its different derivatives: Antioxidative mechanism analysis. Abstract:  The naturally occurring stilbenes piceatannol and its derivatives are excellent antioxidants. In this work, the antioxidative activities of piceatannol and different piceatannol derivatives have been investigated using the density functional theory (DFT) method based on three widely accepted radical scavenging mechanisms, namely, the hydrogen atom transfer (HAT), single electron transfer followed by proton transfer (SET-PT) and sequential proton loss electron transfer (SPLET). The gas and four solvent phases, namely, bond dissociation enthalpy (BDE), ionization potential (IP), proton dissociation enthalpy (PDE), proton affinity (PA) and electron transfer enthalpy (ETE), related to these mechanisms were calculated to elucidate the antioxidative capacities of the investigated compounds. This work focuses specifically on the thermodynamically preferred mechanism, antioxidative site and antioxidative activity order of the investigated stilbenes. The substituted effects of the methyl group and prenyl group on the chemical properties of the remaining OH and CH groups are also analysed. This work confirms the vital role of the OH and CH groups on free radical scavenging of piceatannol and its derivatives.

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Piceatannol can upregulate PI3K-Akt-eNOS signaling to protect cardiomyocytes from peroxidative injury. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2019 Jan ;109:886-891. Epub 2018 Nov 5. PMID: 30551542 Abstract Title:  Piceatannol pretreatment alleviates acute cardiac injury via regulating PI3K-Akt-eNOS signaling in H9c2 cells. Abstract:  Piceatannol (3,3',4,5'-trans-trihydroxystilbene) is a natural polyphenols compound that occurs hydroxylated analogue of resveratrol showing widely biological activities. Previous studies have demonstrated its functions on anti-cancer, neuroprotection and cardioprotection. However, few studies have clarified the benefits of piceatannol on cardiomyocytes except its anti-oxidative effect based on the original property of polyphenols. Here we apply H9c2 cardiomyocytes to study the cardioprotective mechanisms of piceatannol in vitro. We firstly verify its anti-peroxidation effect by using HO-induced in vitro model. Then, flow cytometry results show piceatannol reduce cellular apoptosis by enhancing Bcl-2 expressions in immunoblot analysis. Meantime, piceatannol decreases HO-induced excessive ROS and calcium overloading, and prevents mitochondrial depolarization. Most importantly, piceatannol pretreatment can regulate PI3K-Akt-eNOS signaling pathway to alleviate peroxidative injury. Immunoblot analysis of PI3K, Akt, p-Akt and eNOS shows HOsignificantly reduces expressions of these proteins. Pretreatment of piceatannol evidently increases their expressions and decreases iNOS expression, implying piceatannol can upregulate PI3K-Akt-eNOS signaling to protect cardiomyocytes from peroxidative injury.

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Fisetin is a senotherapeutic that extends health and lifespan. "IndyWatch Feed Health"

PMID:  EBioMedicine. 2018 Oct ;36:18-28. Epub 2018 Sep 29. PMID: 30279143 Abstract Title:  Fisetin is a senotherapeutic that extends health and lifespan. Abstract:  BACKGROUND: Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combination of dasatinib and the flavonoid quercetin is a potent senolytic improving numerous age-related conditions including frailty, osteoporosis and cardiovascular disease. The goal of this study was to identify flavonoids with more potent senolytic activity.METHODS: A panel of flavonoid polyphenols was screened for senolytic activity using senescent murine and human fibroblasts, driven by oxidative and genotoxic stress, respectively. The top senotherapeutic flavonoid was tested in mice modeling a progeroid syndrome carrying a p16-luciferase reporter and aged wild-type mice to determine the effects of fisetin on senescence markers, age-related histopathology, disease markers, health span and lifespan. Human adipose tissue explants were used to determine if results translated.FINDINGS: Of the 10 flavonoids tested, fisetin was the most potent senolytic. Acute or intermittent treatment of progeroid and old mice with fisetin reduced senescence markers in multiple tissues, consistent with a hit-and-run senolytic mechanism. Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity. Administration of fisetin to wild-type mice late in life restored tissue homeostasis, reduced age-related pathology, and extended median and maximum lifespan.INTERPRETATION: The natural product fisetin has senotherapeutic activity in mice and in human tissues. Late life intervention was sufficient to yield a potent health benefit. These characteristics suggest the feasibility to translation to human clinical studies. FUND: NIH grants P01 AG043376 (PDR, LJN), U19 AG056278 (PDR, LJN, WLL), R24 AG047115 (WLL), R37 AG013925 (JLK), R21 AG047984 (JLK), P30 DK050456 (Adipocyte Subcore, JLK), a Glenn Foundation/American Federation for Aging Research (AFAR) BIG Award (JLK), Glenn/AFAR (LJN, CEB), the Ted Nash Long Life and Noaber Foundations (JLK), the Connor Group (JLK), Robert J. and Theresa W. Ryan (JLK), and a Minnesota Partnership Grant (AMAY-UMN#99)-P004610401-1 (JLK, EAA).

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Comparable efficacy of fisetin and vemurafenib for inhibiting melanoma growth was noted in this study. "IndyWatch Feed Health"

PMID:  Sci Rep. 2018 Oct 24 ;8(1):15726. Epub 2018 Oct 24. PMID: 30356079 Abstract Title:  Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models. Abstract:  The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition suppressed tumor cell proliferation and invasion. The p90 ribosomal S6 kinase (RSK), an important ERK effector, activates YB-1 to drive melanoma growth. We found that fisetin treatment of monolayer/3-D melanoma cultures resulted in YB-1 dephosphorylation and reduced transcript levels. In parallel, fisetin suppressed mesenchymal markers and matrix-metalloproteinases in melanoma cells. Data from cell-free/cell-based systems indicated that fisetin inhibited RSK activity through binding to the kinase. Affinity studies for RSK isoforms evaluated stronger interaction for RSK2 than RSK1. Competition assays performed to monitor binding responses revealed that YB-1 and RSK2 do not compete, rather binding of fisetin to RSK2 promotes its binding to YB-1. Fisetin suppressed YB-1/RSK signaling independent of its effect on ERK, and reduced MDR1 levels. Comparable efficacy of fisetin and vemurafenib for inhibiting melanoma growth was noted albeit through divergent modulation of ERK. Our studies provide insight into additional modes of regulation through which fisetin interferes with melanoma growth underscoring its potential therapeutic efficacy in disease progression.

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Fisetin and fisetin nanopartical have the effect of anti-ovarian cancer cells. "IndyWatch Feed Health"

PMID:  Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 Jul ;49(4):551-555. PMID: 30378308 Abstract Title:  [Antitumor Effects of Fisetin and Fisetin Nanopartical on Ovarian Cancer]. Abstract:  OBJECTIVE: To explore the effects of fisetin and fisetin nanopartical on anti-proliferation and apoptosis induction of human ovarian cancer cell line SKOV3.METHODS: The MTT assay was used to determine the survival rate of SKOV3 cell through apoptosis induction after fisetin and fisetin nanopartical treatment, and the drug concentration of the next experiment was selected. 15 nude mice vaccinated SKOV3 cells mixture mode randomly into three groups, treatment began on the fifth day, every 3 d injection times, each time 0.2 mL, a total of 12 times. Group A for the control (50 mL/L glucose solution), group B for fisetin (1.25 mg/kg), group C for fisetin nanopartical (1.25 mg/kg). After the treatment, tumor quality was recorded, and histopathological lesions were observed by HE staining on heart, liver, spleen, lung and kidney sections. The proliferation of SKOV3 cells was detected by Ki67 immunohistochemical staining in tumor tissue sections, and apoptosis of SKOV3 cells was detected by TUNEL assay.RESULTS: MTT test indicated that fisetin and fisetin nanopartical had inhibition effect on ovarian cancer cell in a dose-dependent manner. The half-maximal inhibitory concentration (IC) value for fisetin and fisetin nanopartical were 125-250g/mL and 62.5-125 g/mL. Therefore, the working concentration was selected as 125 g/mL. 11 mice were completed and survived until the end of the experiment (3 in group A,4 in group B,4 in group C). Group A nude mice abdominal cavity in cauliflower shape tumor nodules, B and C group only tiny granule tumor nodules, B and C group of intraperitoneal tumor mass is quite (>0.05), but were lower than group A (

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Fisetin can be considered as a potential cardioprotective agent during the management of carcinoma using doxorubicin anthracyclines. "IndyWatch Feed Health"

PMID:  Mol Biol Rep. 2018 Oct 25. Epub 2018 Oct 25. PMID: 30362071 Abstract Title:  Fisetin, a plant flavonoid ameliorates doxorubicin-induced cardiotoxicity in experimental rats: the decisive role of caspase-3, COX-II, cTn-I, iNOs and TNF-. Abstract:  Doxorubicin (DOX) is a widely used anthracycline antibiotic for the management of carcinoma. However, it is associated with cardiotoxicity. Fisetin is a plant flavonoid reported to have anti-inflammatory and antiapoptotic potential. To evaluate the cardioprotective potential of fisetin in DOX-induced cardiotoxicity in experimental rats. Sprague-Dawley rats were pre-treated with either fisetin (10, 20 and 40 mg/kg) or sitagliptin (10 mg/kg, p.o.) for 7 days. Cardiac toxicity was induced in rats (except the normal group) by doxorubicin (15 mg/kg i.p.) on 8th day. Various behavioral, biochemical, molecular and histological parameters were assessed in cardiac tissue. DOX-induced alterations in electrocardiographic, hemodynamic and left ventricular function were significantly (p

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Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell. "IndyWatch Feed Health"

PMID:  J Cell Mol Med. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30411496 Abstract Title:  Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell. Abstract:  As a natural flavonol, fisetin has significant inhibitory effects on many cancers. Although fisetin can inhibit kidney cancer, its effects on kidney renal stem cells (HuRCSCs) remain unknown. Our study found that renal cancer tissues and CD44+/CD105+ HuRCSCs both show high TET1 protein expression. Both in vivo and in vitro experiments showed that fisetin can effectively inhibit HuRCSC cell division and proliferation, invasion, in vivo tumourigenesis and angiogenesis. Our findings showed that fisetin can significantly decrease TET1 expression levels in HuRCSCs and overall 5hmC levels in the genomes of these cells. At the same time, ChIP-PCR results showed that fisetin can effectively inhibit 5hmC modification levels at the CpG islands in cyclin Y (CCNY) and CDK16 and reduce their transcription and activity. Thus, we conclude that fisetin inhibits the epigenetic mechanism in renal cancer stemcells, that is, fisetin inhibits TET1 expression and reduces 5hmC modification in specific loci in the promoters of CCNY/CDK16 in HuRSCs. This in turn inhibits transcription of these genes, causing cell cycle arrest and ultimately inhibiting renal cancer stem cell activity.

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Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits. "IndyWatch Feed Health"

PMID:  Psychopharmacology (Berl). 2018 Nov 14. Epub 2018 Nov 14. PMID: 30426184 Abstract Title:  Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-B and IDO-1. Abstract:  BACKGROUND: Fisetin, a plant active polyphenol, is well known for its antioxidant and free radical scavenging activities. The present study was designed to explore the detailed molecular mechanism underlying its neuroprotective effects.METHODS: The young male mice were either administered a single dose of lipopolysaccharide (0.83 mg/kg) or subjected to restraint stress (6 h per day for 28 days) to induce behavioral deficits in different groups. Fisetin (15 mg/kg) was orally administered for the last 14 days of the study.RESULTS: Lipopolysaccharide (LPS) as well as restraint stress (RS) exposure caused behavioral alterations (anxiety and depressive-like behavior). Gene expression analysis showed upregulation of nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-B) and indoleamine 2,3-dioxygenase (IDO)-1 gene expression along with downregulation of Nrf-2 (nuclear factor erythroid 2-related factor 2), HO-1 (heme oxygenase-1), and ChAT (choline acetyltransferase) gene expression level in RS and RS+LPS groups. Fisetin administration significantly amelioratedbehavioral and neurochemical deficits in LPS, RS, and RS+LPS groups.CONCLUSION: These findings clearly indicated that fisetin administration improved behavioral functions and suppressed the NF-B and IDO-1 (indoleamine 2,3-dioxygenase) activation along with their antioxidant effect, suggesting fisetin as an intriguing nutraceutical for the management of inflammation-associated neurological disorders.

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Fisetin induces apoptosis in breast cancer MDA-MB-453 cells. "IndyWatch Feed Health"

PMID:  J Biochem Mol Toxicol. 2018 Nov 15:e22268. Epub 2018 Nov 15. PMID: 30431692 Abstract Title:  Fisetin induces apoptosis in breast cancer MDA-MB-453 cells through degradation of HER2/neu and via the PI3K/Akt pathway. Abstract:  Overexpression of human epidermal growth factor receptor 2 (HER2) is observed in breast cancer. The major snag faced by the human population is the development of chemoresistance to HER2 inhibitors by advanced stage breast cancer cells. Moreover, recent researchers focussed on fisetin as an antiproliferative and chemotherapeutic agent. Therefore, this study was intended to analyze the effects of fisetin onHER2/neu-overexpressing breast cancer cell lines. Our results depicted that fisetin induced apoptosis of these cells by various mechanisms, such as inactivation of the receptor, induction of proteasomal degradation, decreasing its half-life, decreasing enolase phosphorylation, and alteration of phosphatidylinositol 3-kinase/Akt signaling.

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Emodin showed excellent hepatoprotective effects against lipopolysaccharide-induced acute liver injury. "IndyWatch Feed Health"

PMID:  Front Pharmacol. 2018 ;9:962. Epub 2018 Aug 22. PMID: 30186181 Abstract Title:  Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathwayand. Abstract:  Emodin is an anthraquinone with potential anti-inflammatory properties. However, the possible molecular mechanisms and protective effects of emodin are not clear. The objective of this study was to investigate the possible molecular mechanisms and protective effects of emodin on lipopolysaccharide (LPS)-induced acute liver injury (ALI) via the Toll-like receptor 4 (TLR4) signaling pathway in the Raw264.7 cell line and in Balb/c mice.This study established an inflammatory cellular model and induced an ALI animal model. TLR4 was overexpressed by lentivirus and downregulated by small interfering RNA (siRNA) technology. The mRNA and protein levels of TLR4 and downstream molecules were detected in cells and liver tissue. The tumor necrosis factor- (TNF-) and interleukin (IL)-6 levels in supernatant and serum were determined by ELISA. The distribution and expression of mannose receptor C type 1 (CD206) and arginase 1 (ARG1) in the liver were tested by immunofluorescence. Mouse liver function and histopathological observations were assessed.Administration of emodin reduced the protein and/or mRNA levels of TLR4 and its downstream molecules following LPS challenge in Raw264.7 cells and in an animal model. Additionally, emodin suppressed the expression of TNF- and IL-6 in cell culture supernatant and serum. The inhibitory effect of emodin was also confirmed in RAW264.7 cells, in which TLR4 was overexpressed or knocked down. Additionally, ARG1 and CD206 were elevated in the emodin groups. Emodin also decreased serum ALT and AST levels and alleviated theliver histopathological damage induced by LPS.Emodin showed excellent hepatoprotective effects against LPS-induced ALI, possibly by inhibiting TLR4 signaling pathways.

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Aloe-emodin induces endoplasmic reticulum stress-dependent apoptosis in colorectal cancer cells. "IndyWatch Feed Health"

PMID:  Med Sci Monit. 2018 Sep 10 ;24:6331-6339. Epub 2018 Sep 10. PMID: 30199885 Abstract Title:  Aloe-Emodin Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Colorectal Cancer Cells. Abstract:  BACKGROUND Recently, colorectal cancer has become a more common type of tumor in the world. Research has reported that several kinds of single compounds of Chinese herbs have shown anti-tumor activity in colorectal cancer. Aloe-emodin (AE), a natural compound extract from Aloe Vera, has been discovered to suppress cell proliferation and accelerate apoptosis in a variety of tumor cells. Whether AE exerts an effect on colorectal cancer cells has not yet been investigated. MATERIAL AND METHODS In this study, we examined the impact of AE on SW620 and HT29 colorectal cancer cell lines. After treatment with various concentrations of AE (10, 20, and 40M), cell proliferation, cell apoptosis, reactive oxygen species (ROS) generation, cytosolic calcium level, and related gene expression were analyzed. RESULTS Our results indicated that AE suppressed cell viability and induced cell apoptosis in SW620 and HT29 cell lines. Furthermore, both cell lines when exposed to AE generated ROS, which induces endoplasmic reticulum (ER) stress. We then detected the expression of ER stress-related proteins and cytosolic calcium levels. We found that cells exposure to AE had upregulation of unfolded protein response (UPR) proteins like glucose-related protein 78 (GRP78), phosphorylated protein kinase R (PKR)-like ER kinase (p-PERK), phosphorylated eukaryotic initiation factor-2 (p-eIF2), and transcription factor C/EBP homologous protein (CHOP). Meanwhile, we detected an increased cytosolic calcium content followed by the upregulation of the calpain-1, calpain-2 and caspase-12. CHOP and caspase-12 are important regulatory factors leading to cell apoptosis. CONCLUSIONS AE might serve as a candidate in the treatment of colorectal cancer through inducing ER stress-dependent apoptosis.

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Effects of aloe emodin on U87MG glioblastoma cell growth. "IndyWatch Feed Health"

PMID:  Environ Toxicol. 2018 Nov ;33(11):1160-1167. Epub 2018 Sep 15. PMID: 30218594 Abstract Title:  Effects of aloe emodin on U87MG glioblastoma cell growth: In vitro and in vivo study. Abstract:  Glioblastoma, the most aggressive and malignant form of glioma, appears to be resistant to various chemotherapeutic agents. Hence other approaches have been investigated to target more pathways involved in glioblastoma development and progression. Here we investigate the anticancer effect of Aloe-Emodin (AE), an anthraquinone compound presents in the leaves of Aloe arborescens, on human glioblastoma cell line U87MG. U87MG were treated with various concentrations of AE (20 and 40M) for different times (24, 48, and 72hr). Cell growth was monitored by daily cell count after treatments. Growth analysis showed that AE significantly decrease proliferation of U87MG in a time and dose dependent manner. FACS analysis demonstrates a block of cell cycle in S and G2/M phase. AE probably induced also apoptosis by releasing of apoptosis-inducing factor: PARP and Lamin activation leading to nuclear shrinkage. In addition, exposure of U87MG to AE reduced pAKT phosphorylation. AE inhibition of U87MG growth is a result of more mechanism together. Here we report that AE has a specific growth inhibition on U87MG also in in vivo. The growth of U87MG, subcutaneously injected in nude mice with severe combined immunodeficiency, is inhibited without any appreciable toxic effects on the animals after AE treatment. AE might represent a conceptually new lead antitumor adjuvant drug.

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The combination of Emodin and ginsenoside Rb1 exerts synergistically neuroprotective functions in cerebral ischemia-reperfusion injury. "IndyWatch Feed Health"

PMID:  Front Pharmacol. 2018 ;9:943. Epub 2018 Aug 28. PMID: 30233364 Abstract Title:  Combined Use of Emodin and Ginsenoside Rb1 Exerts Synergistic Neuroprotection in Cerebral Ischemia/Reperfusion Rats. Abstract:  Acute ischemic stroke (AIS) generally causes neurological dysfunction and poses a serious threat to public health. Here, we aimed to assess the independent and combined effects of ginsenoside Rb1 (GRb1) and Emodin on neuroprotection through regulating Connexin 43 (Cx43) and Aquaporin 4 (AQP4) expression in cerebral ischemia/reperfusion (I/R) model rats. Adult male Sprague-Dawley (SD) rats were randomly divided into five groups: sham group, I/R group, Emodin group, GRb1 group and Emodin+GRb1 group. They were further allocated to four subgroups according to the 6h, 1d, 3d, and 7d time points except the sham group. Based on the modified Longa suture method, the focal cerebral I/R model was established by middle cerebral artery occlusion (MCAO). The neurological deficit scores (NDS), blood brain barrier (BBB) permeability and cerebral infarction area were assessed at each corresponding time point. Cx43 and AQP4 levels were assessed by Real-time PCR and Immunofluorescence. Compared with I/R group, both the independent and combined use of GRb1 and Emodin could alleviate NDS, reduce the BBB permeability, reduce the infarction area and down-regulate Cx43 and AQP4 expression at 6h, 1d, 3d, and 7d after I/R (

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Study shows magnesium optimizes vitamin D levels: high or low "IndyWatch Feed Health"

Study shows magnesium optimizes vitamin D levels: high or low

Great news! Having optimum magnesium levels means you probably have optimum vitamin D levels. New research takes some of the confusion out of getting your vitamin D requirements.

A randomized trial by Vanderbilt-Ingram Cancer Center researchers indicates that magnesium optimizes vitamin D status, raising it in people with deficient levels and lowering it in people with high levels.

The study reported in the December issue of The American Journal of Clinical Nutrition is important because of controversial findings from ongoing research into the association of vitamin D levels with colorectal cancer and other diseases, including a recent report from the VITAL trial. It gave confirmation to a prior observational study in 2013 by the researchers that linked low magnesium levels with low vitamin D levels.

The trial also revealed something new that magnesium had a regulating effect in people with high vitamin D levels. The research provides the first evidence that magnesium may play an important role in optimizing vitamin D levels and preventing conditions related to vitamin D levels.

Qi Dai, MD, PhD, Ingram Professor of Cancer Research, the studys lead author, described the ideal level as being in the middle range of a U-shape because vitamin D at this level has been linked to the lowest risk of cardiovascular disease in previous observational studies.



Johnson & Johnson Knew About Asbestos in Baby Powder for Decades "IndyWatch Feed Health"

Johnson & Johnson Knew About Asbestos in Baby Powder for Decades

Reuters investigation published Friday charges that Johnson & Johnson, a multi-billion dollar company known for its healthcare products, knew for decades that its iconic talcum baby powder was sometimes tainted with carcinogenic asbestos, but concealed the information from regulators and the public.

Asbestos, the name given to six minerals that occur naturally in the environment as bundles of fibers, has been used in North Americas automotive, construction, and shipbuilding industries since the late 1800s, according to the National Cancer Institute. The World Health Organization (WHO) warns that all types of asbestos cause lung cancer, mesothelioma, cancer of the larynx and ovary, and asbestosis (fibrosis of the lungs).

Because asbestos sometimes occurs in the earth along with talc, contamination is possible. Reutersalong with attorneys for more than 11,000 plaintiffs currently suing Johnson & Johnson, claiming the companys products caused their cancerexamined memos, internal reports, and other confidential documents as well as deposition and trial testimony.



Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer. "IndyWatch Feed Health"

PMID:  Mol Med Rep. 2018 Dec ;18(6):5191-5197. Epub 2018 Sep 26. PMID: 30272291 Abstract Title:  Emodin suppresses angiogenesis and metastasis in anaplastic thyroid cancer by affecting TRAF6mediated pathways in vivo and in vitro. Abstract:  Emodin has been recognized to be an anticancer agent against a number of types of human cancer. It was demonstrated that TNF receptorassociated factor 6 (TRAF6) was correlated with cancer angiogenesis and metastasis. The present study confirmed the association between TRAF6 and the angiogenesis/metastasis of anaplastic thyroid cancer (ATC). The antiangiogenesis and metastatic effects of emodin, in addition to its molecular mechanisms in ATC, were investigated. A total of two ATC cell lines, namely 8505c and SW1736, were studied. ATC cells were implanted into nude mice to form xenografts or to establish lung metastasis models. Emodin was used to incubate ATC cells or to treat animals orally. An MTT assay was used to assess cell proliferation. A wound healing assay was employed to evaluate cell migration. ELISA analysis was used to detect the vascular endothelial growth factor (VEGF) content. Western blotting was used to determine the protein expression levels. In the in vivo study, cancer angiogenesis was assessed by micro vascular density measurement. The lung metastatic rate was the criterion for cancer metastasis. The results of the present study demonstrated that the proliferation of ATC was inhibited by emodin. The activation of the TRAF6/hypoxia inducible factor (HIF)1/VEGF and TRAF6/basigin (CD147)/matrix metalloproteinase9 (MMP9) pathways were associated with the angiogenesis and metastasis of ATC. In a concentrationdependent manner, emodin inhibited the TRAF6/HIF1/VEGF and TRAF6/CD147/MMP9 signaling pathways to suppress angiogenesis and metastasis. In conclusion, emodin exerted antiangiogenic and antimetastatic activities in ATC by affecting TRAF6mediated pathways.

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Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2018 Nov 10 ;505(4):973-978. Epub 2018 Sep 28. PMID: 30274778 Abstract Title:  Low dose Emodin induces tumor senescence for boosting breast cancer chemotherapy via silencing NRARP. Abstract:  PURPOSE: The resistance to 5-FU often limits its clinical effectiveness on breast cancer treatment. Combination therapy thus is employed to overcome this treatment resistance. We here report a potent antitumor effect of Emodin at low dose on chemotherapy sensitivity of MCF-7 breast cancer cells.METHODS: Cell viability, apoptosis, glutathiones (GSH) concentration and Reactive oxygen species (ROS) activity following Emodin and 5-FU treatment was assessed. Cellular senescence following combined treatment and silence of NRARP was examined by senescence-associated-galactosidase analysis. Western blot analysis was used to determine changes in the expression of p21, p16, p27, E2F1 and NRARP.RESULTS: Low dose Emodin potentiates 5-FU-induced apoptosis of breast cancer cells, in association with inhibition of NRARP, resulting in cellular senescence. RNA interference of NRARP induced cellular senescence in MCF-7 breast cancer cells. Furthermore, the cellular senescence induced by Emodin and 5-FU treatment could be reverted by pcDNA-NRARP.CONCLUSION: These findings provide preclinical evidence for repurposing use of Emodin in combination with chemotherapeutic agents to treat breast cancer as an alternative salvage regimen.

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The combination of emodin and sorafenib may offer a potential therapy for patients with advanced liver cancer. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2018 Oct 12 ;19(10). Epub 2018 Oct 12. PMID: 30321984 Abstract Title:  Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. Abstract:  Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC). Emodin is an active component of Chinese herbs, and is effective against leukemia, lung cancer, colon cancer, pancreatic cancer, and HCC; however, the sensitizing effect of emodin on sorafenib-based HCC therapy has not been evaluated. Here, we demonstrate that emodin significantly improved the anti-cancer effect of sorafenib in HCC cells, such as HepG2, Hep3B, Huh7, SK-HEP-1, and PLC/PRF5. Mechanistically, emodin inhibits sterol regulatory element-binding protein-2 (SREBP-2) transcriptional activity, which suppresses cholesterol biosynthesis and oncogenic protein kinase B (AKT) signaling. Additionally, attenuated cholesterol synthesis and oncogenic AKT signaling inactivated signal transducer and activator of transcription 3 (STAT3), an oncogenic transcription factor. Furthermore, emodin synergistically increased cell cycle arrest in the G1 phase and apoptotic cells in the presence of sorafenib. Animal models xenografted with HepG2 or SK-HEP-1 cells also showed that the combination of emodin and sorafenib was sufficient to inhibit tumor growth. Overall, these results suggested that the combination of emodin and sorafenib may offer a potential therapy for patients with advanced HCC.

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Emodin represents a novel potential candidate agent for hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features. "IndyWatch Feed Health"

PMID:  Int J Neuropsychopharmacol. 2018 Nov 8. Epub 2018 Nov 8. PMID: 30407508 Abstract Title:  Emodin rescued hyperhomocysteinemia-induced dementia and Alzheimer's disease-like features in rats. Abstract:  Background: Hyperhomocysteinemia (HHcy) is an independent risk factor for dementia, including Alzheimer's disease (AD). Lowering homocysteine levels with folic acid treatment with or without vitamin B12 was shown few clinical benefits on cognition.Methods: To verify the effect of emodin, a naturally active compound from Rheum officinale, on HHcy-induced dementia, rats were treated with homocysteine injection (HCY, 400 g/kg/day, 2 weeks) via vena caudalis. Afterwards, HCY rats with cognitive deficits were administered intragastric emodin at different concentrations, namely, 0 (HCY-E0), 20 (HCY-E20), 40 (HCY-E40) and 80 mg/kg/day (HCY-E80) for 2 weeks.Results: -amyloid (A) overproduction, tau hyperphosphorylation and losses of neuron and synaptic proteins were detected in the hippocampi of HCY-E0 rats with cognitive deficits. HCY-E40 and HCY-E80 rats had better behavioural performances. Although it did not reduce the plasma homocysteine level, emodin(especially 80 mg/kg/day) reduced the levels of A and tau phosphorylation, decreased the levels of -site amyloid precursor protein-cleaving enzyme 1, and improved the activity of protein phosphatase 2A. In the hippocampi of HCY-E40 and HCY-E80 rats, the neuron numbers, levels of synaptic proteins and phosphorylation of the cAMP responsive element-binding protein at Ser133 were increased; in addition, depressed microglial activation and reduced levels of 5-lipoxygenase, interleukin-6 and tumour necrosis factor were also observed. Lastly, HHcy-induced microangiopathic alterations, oxidative stress and elevated DNA methyltransferases 1 and 3 were rescued by emodin.Conclusions: Emodin represents a novel potential candidate agent for HHcy-induced dementia and AD-like features.

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Emodin is able to promote the proliferation of chondrocytes. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2018 Dec ;16(6):5384-5389. Epub 2018 Oct 18. PMID: 30542499 Abstract Title:  Effect of emodin on chondrocyte viability in anmodel of osteoarthritis. Abstract:  Emodin is an anthraquinone isolated from the Chinese herb Radix et Rhizoma Rhei and has been used to treat various diseases for centuries. The aim of the present study was to investigate the effect of emodin on the inflammatory mediators in rat chondrocytes. In the present study, chondrocytes were isolated from rats, cultured and harvested when they reached generation P3. Cells were treated with different doses of emodin (10, 20, and 30g/ml) followed by interleukin 1 (IL-1, 10 ng/ml). Control cells were either untreated or treated with IL-1 alone. An enzyme-linked immunosorbent assay was used to measure levels of nitric oxide (NO) and prostaglandin E2 (PGE2). Reverse transcription-quantitative polymerase chain was performed to measure levels of matrix metallopeptidase (MMP)-3 and -13 mRNA. The expression of MMP-3, MMP-13, extracellular-signal regulatory kinase (ERK)1/2, phosphorylated ERK1/2 and -catenin proteins were detected by western-blot analysis. The results demonstrated that treatment with emodin treatment reduced the cytotoxicity of IL-1 and inhibited the expression of NO and PGE2 in rat chondrocytes. Furthermore, emodin inhibited the expression of MMP3 and MMP13, and the phosphorylation of various proteins involved in the ERK and Wnt/-catenin pathway. Therefore, emodin is able to promote the proliferation of chondrocytes by inhibiting the ERK and Wnt/-catenin pathway and downregulating the expression of a series of inflammatory mediators in chondrocytes.

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Emodin may be an efficient candidate natural product for severe acute pancreatitis treatment. "IndyWatch Feed Health"

PMID:  Oncol Rep. 2018 Nov 2. Epub 2018 Nov 2. PMID: 30542707 Abstract Title:  Emodin attenuated severe acute pancreatitis via the P2X ligandgated ion channel 7/NODlike receptor protein 3 signaling pathway. Abstract:  Acute pancreatitis (AP) is an aseptic inflammation characterized with an annual incidence rate, and ~20% patients progressing to severe AP (SAP) with a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, the actual mechanism of its protective effects remains unknown. As the major active ingredient of Qingyi decoction, emodin was selected in the present study to investigate the effect of emodin against severe acute pancreatitis (SAP) in rats through NODlike receptor protein 3(NLRP3) inflammasomes. The rats were randomly divided into a sham operation group, an SAP model group induced by a standard retrograde infusion of 5.0% sodium taurocholate into the biliopancreatic duct, and lowdose (30 mg/kg) and highdose (60 mg/kg) emodintreated groups. At 12 h after the event, the plasma amylase, lipase, interleukin (IL)1, IL18 and myeloperoxidase (MPO) activities were examined. Furthermore, the pathological scores of pancreases were evaluated by hematoxylin and eosin staining. The expression levels of P2X ligandgated ion channel 7 (P2X7), NLRP3, apoptosisassociated specklike protein containing a Cterminal caspase recruitment domain and caspase1 were also analyzed by western blot analysis. The data demonstrated that, compared with the SAP group, emodin could significantly relieve the pancreatic histopathology and acinar cellular structure injury, and notably downregulate the plasma amylase and lipase levels, as well as the MPO activities in pancreatic tissues, in a dosedependent manner. Furthermore, emodin inhibited the P2X7/NLRP3 signaling pathway followed by the decrease of proinflammatory factors, and the latter is beneficial for the recovery of SAP. Collectively, the data indicated that emodin may be an efficient candidate natural product for SAP treatment.

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The current results may support the use of A. vera extract as antibacterial agent against methicillin resistant S. aureus infections. "IndyWatch Feed Health"

PMID:  Pak J Pharm Sci. 2018 Sep ;31(5(Supplementary)):2123-2130. PMID: 30393222 Abstract Title:  Aloe vera extract: A novel antimicrobial and antibiofilm against methicillin resistant Staphylococcus aureus strains. Abstract:  Bacterial infectious maladies are the leading cause of death worldwide. Microbial drug resistance boosts the severity of the maladies. In the present study, the antibacterial impact of Aloe vera leaf aqueous extract against six strains of methicillin resistant Staphylococcus aureus (LN872136, LN872137, LN871238, LN871239, LN872140, LN871241) was investigated in vitro. The effect of different concentrations (5-20mg/ ml) of the plant extract on bacterial growth was evaluated by estimating the dry weight of bacterial biomass obtained from cultures at 24 and 48 h after exposure to the plant extract. The results revealed that the plant extract at concentrations of 15-20mg/ml, markedly reduced the dry weights of most S. aureus strains after 24 and/or 48 h exposure periods. The effects of the plant extract (20mg/ml) on the inhibition zones and biofilm formation by S. aureus six strains were also investigated. The largest inhibition zone was recorded against S. aureus (LN871241) and confirmed by scanning electron microscope. The plant extract could also block the biofilm formation by most S. aureus strains. In conclusion, the current results may support the use of A. vera extract as antibacterial agent against methicillin resistant S. aureus infections.

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Emodin reduces the activity of (1,3)--D-glucan synthase from Candida albicans and does not interact with caspofungin. "IndyWatch Feed Health"

PMID:  Pol J Microbiol. 2018 ;67(4):463-470. PMID: 30550232 Abstract Title:  Emodin Reduces the Activity of (1,3)--D-glucan Synthase fromand Does Not Interact with Caspofungin. Abstract:  : Candidiasis is the most common opportunistic yeast infection, with Candida albicans as a paramount causative species. (1,3)- -D-glucan is one of the three main targets of clinically available antifungal agents used to treat Candida infections. It is one of the most abundant fungal cell wall components. Echinocandins represent the newest class of antifungals affecting cell wall biosynthesis through non-competitive inhibition of (1,3)- -D-glucan synthase. Therefore, treatment with echinocandins causes defects in fungal cell integrity. In the present study, similar activity of emodin (6-methyl-1,3,8-trihydroxyanthraquinone) has been revealed. Many reports have already shown the antifungal potential of this pleiotropic molecule, including its activity against C. albicans . The aim of this report was to evaluate the activity of emodin towards a new molecular target, i.e. (1,3)- -D-glucan synthase isolated from Candida cells. Moreover, given the identical mechanism of the activity of both molecules, interaction of emodin with caspofungin was determined. The study revealed that emodin reduced (1,3)- -D-glucan synthase activity and increased cell wall damage, which was evidenced by both a sorbitol protection assay and an aniline blue staining assay. Furthermore, the synergy testing method showed mainly independence of the action of both tested antifungal agents, i.e. emodin and caspofungin used in combination.: Candidiasis is the most common opportunistic yeast infection, withas a paramount causative species. (1,3)--D-glucan is one of the three main targets of clinically available antifungal agents used to treatinfections. It is one of the most abundant fungal cell wall components. Echinocandins represent the newest class of antifungals affecting cell wall biosynthesis through non-competitive inhibition of (1,3)--D-glucan synthase. Therefore, treatment with echinocandins causes defects in fungal cell integrity. In the present study, similar activity of emodin (6-methyl-1,3,8-trihydroxyanthraquinone) has been revealed. Many reports have already shown the antifungal potential of this pleiotropic molecule, including its activity against. The aim of this report was to evaluate the activity of emodin towards a new molecular target, i.e. (1,3)--D-glucan synthase isolated fromcells. Moreover, given the identical mechanism of the activity of both molecules, interaction of emodin with caspofungin was determined. The study revealed that emodin reduced (1,3)--D-glucan synthase activity and increased cell wall damage, which was evidenced by both a sorbitol protection assay and an aniline blue staining assay. Fur...


Coconut Oil Beats Toxic DEET at Repelling Insects "IndyWatch Feed Health"

Millions use a toxic chemical known as DEET to repel insects. Compelling new research shows that a far safer and more effective food-based alternative exists.

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Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells. "IndyWatch Feed Health"

PMID:  BMC Complement Altern Med. 2018 Nov 7 ;18(1):296. Epub 2018 Nov 7. PMID: 30404637 Abstract Title:  Aloe-emodin induces apoptosis in human oral squamous cell carcinoma SCC15 cells. Abstract:  BACKGROUND: Oral and pharyngeal cancer is the most common malignant human cancers. Chemotherapy is an effective approach for anti-oral cancer therapy, while the drug tolerance and resistance remain a problem for oral cancer patients. Aloe-emodin, rhein and physcion are classified as anthraquinones, which are the main pharmacodynamic ingredients of Rheum undulatum L.. This study was undertaken to investigate whether aloe-emodin, rhein and physcion show inhibiting growth and inducing apoptosis in oral squamous cell carcinoma SCC15 cells. We found that aloe-emodin show inhibiting growth and inducing apoptosis in oral squamous cell carcinoma SCC15 cells, we also investigated the underlying mechanisms of apoptosis induced by aloe-emodin.METHODS: Thiazolyl blue tetrazolium bromide (MTT) test was used to detect cell proliferation. Cell apoptosis was detected by flow cytometry. We also used western blot analysis to detect the potential mechanisms of apoptosis.RESULTS: Aloe-emodin, rhein and physcion inhibit the proliferation of SCC15 cells and the order of inhibition level are aloe-emodin>Rhein>Physcion, the half maximal inhibitory concentrations (IC) value of aloe-emodin was 60.90 M at 48 h of treatment. Aloe-emodin treatment resulted in a time- and dose-dependent decrease in cell viability and increased the apoptotic cell ratio. The results of western blotting showed the expression levels of caspase-9 and caspase-3 proteins increased following aloe-emodin treatment.CONCLUSIONS: Our results revealed that aloe-emodin treatment could inhibit cell viability of SCC15 cells and the potential mechanism of inhibition might be through the induction of apoptosis by regulation of the expression levels of caspase-9 and caspase-3. This indicates that aloe-emodin may be a good agent for anti-oral cancer drug exploring.

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Ultrasound mediated accelerated Anti-influenza activity of Aloe vera "IndyWatch Feed Health"

PMID:  Sci Rep. 2018 Dec 12 ;8(1):17782. Epub 2018 Dec 12. PMID: 30542141 Abstract Title:  Ultrasound mediated accelerated Anti-influenza activity of Aloe vera. Abstract:  Aloe vera (AV) is popular and has been commercialized as a beauty product, laxative, herbal medicine, the antimicrobial activity of AV is proven. The antiviral activity of AV however, has not been well documented except for a handful reports. Till date extraction of AV compounds is popularized using organic solvents, since the active components are effectively extracted in methanol. In the current work, we have employed a 5min ultrasound based extraction for the effective extraction of aloin and aloe-emodin compounds from AV in water. This rapid, one-pot extraction process resulted in enhanced extraction of flavonoids and phenolics and enrichment of the aloin and aloe-emodin moieties in the ulrasonicated water extracts. The extracts were tested for their anti-influenza activity and, the results showed that the ultrasound extraction enabled the water extracts to show excellent anti influenza activity comparable to that seen in the methanolic extracts. Compared to the methanolic extracts which showed high cytotoxicity, the water extracts showed zero cytotoxicity. Spectrophotometric scans of the extracts confirmed the enrichment of the aloin and aloe emodin peaks in the ultrasonicated extracts of AV, suggesting their handiwork behind the anti-influenza activity. The demonstrated technique if appropriatelyimplicated, would lead to promising solutions in the pharmaceutical pursuit against influenza virus.

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Why Most Doctors are Wrong About Cholesterol "IndyWatch Feed Health"

Screen Shot 2018-12-17 at 11.20.10 AM

Why Your Doctor is Wrong About Cholesterol

Written by Dr. Joseph Mercola

Cholesterol is a waxy substance found in nearly every cell of your body and is essential to good health. It plays a role in hormone production, digestion and the manufacture of vitamin D following sun exposure, and helps protect your cell membranes.

As noted by Zoe Harcombe, Ph.D.,1

It is virtually impossible to explain how vital cholesterol is to the human body. If you had no cholesterol in your body you would be dead.

Your liver manufactures most, about 80 percent, of the cholesterol your body requires, which in and of itself suggests your body cannot survive without it. The remaining 20 percent comes from your diet. However, dietary cholesterol is absorbed at a rate of 20 to 60 percent, depending on the individual,2and if you consume less, your body will compensate by making more and vice versa.

Animals use cholesterol in much the same way, hence beef, pork and chicken have similar levels of cholesterol, averaging 25 milligrams of cholesterol per ounce.3

Cholesterol has long been vilified as a primary cause of cardiovascular disease (CVD), yet numerous studies refute this hypothesis, demonstrating that cholesterol has virtually nothing to do with heart disease at least not in the way conventional medicine presents it.

As noted by Harcombe, the notion that there is good and bad cholesterol is also wrong. Low-density lipoprotein (LDL) and high-density lipoprotein (HDL) are not actually cholesterol; theyre carriers and transporters...


Cardioprotective effects of spirulina therapy in children with beta-thalassemia major. "IndyWatch Feed Health"

PMID:  J Pediatr Hematol Oncol. 2018 Dec 7. Epub 2018 Dec 7. PMID: 30531602 Abstract Title:  Cardioprotective Effects of Spirulina Therapy in Children With Beta-Thalassemia Major. Abstract:  INTRODUCTION: Cardiac failure in children with Thalassemia major (TM) is the major cause of death due to iron overload. Spirulina is a micro alga with proven anti-inflammatory, antioxidant and may have a cardioprotective effect.AIM OF THE WORK: The aim of this study was to evaluate the possible beneficial effect of spirulina supplement in TM children.SUBJECT AND METHODS: It is an interventional study carried out in 60 children with TM and 30 healthy children matched for age and sex as control. Both groups received spirulina supplement at a dose of 250mg/kg/d for 3 months. 2D Echo, Tissue Doppler, and speckle tracking imaging (STI) were done for all the studied cohort before and after the 3-month duration of spirulina supplement.RESULTS: There was significant improvement in hemoglobin level at the end of 3-month period (8.271.3 vs. 9.0231.7; P

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Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2019 Jan ;109:314-321. Epub 2018 Nov 3. PMID: 30396089 Abstract Title:  Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Abstract:  Aspirin is a commonly prescribed non steroidal anti-inflammatory drug, but its prolonged use injures the gastric mucosa. The present study was carried out to evaluate the ameliorative effect of spirulina against aspirin-induced gastric ulcer in albino mice. Gastric ulcer was induced by oral administration of aspirin (500mg/kg bw). Spirulina (250 and 500mg/kg bw) was given orally for 3 days after the induction of gastric ulcer. Spirulina ameliorated aspirin-induced gastric ulcer by improving the gross morphology, histology and mucous layer of gastric tissue, augmenting the endogenous enzymatic and non-enzymatic antioxidants (reduced glutathione, glutathione peroxidase, glutathione reductase, superoxide dismutase and catalase) and the cytoprotective marker (COX-1), and by alleviating tissue levels of the lipid peroxidation marker (malondialdehyde) and inflammatory mediators (TNF-, COX-2 and NO). In conclusion, spirulina has a therapeutic potential in aspirin-induced gastric injury by alleviating oxidative stress and inflammation.

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Spirulina supplementation has favorable effect on select cardiovascular and metabolic biomarkers in humans. "IndyWatch Feed Health"

PMID:  Diabetes Metab Syndr Obes. 2018 ;11:729-742. Epub 2018 Nov 14. PMID: 30532573 Abstract Title:  Quantifying the effects of spirulina supplementation on plasma lipid and glucose concentrations, body weight, and blood pressure. Abstract:  Purpose: Spirulina is generally used as a nutraceutical food supplement due to its nutrient profile, lack of toxicity, and therapeutic effects. Clinical trials have investigated the influence of spirulina on metabolic-related risk factors but have yielded conflicting results in humans. Here, we summarize the evidence of the effects of spirulina on serum lipid profile, glucose management, BP, and body weight by conducting a meta-analysis.Materials and methods: Relevant studies were retrieved by systematic search of MEDLINE, EMBASE, Scopus databases, and reference lists of relevant original studies from inception to July 2018. Data were extracted following a standardized protocol. Two investigators independently extracted study characteristics, outcomes measures, and appraised methodological quality. Effect sizes were performed using a random-effects model, with weighted mean differences (WMDs) and 95% CIs between the means for the spirulina intervention and control arms. Subgroup analyses were conducted to explore the possible influences of study characteristics. Publication bias and sensitivity analysis were also performed.Results: A total of 1,868 records were identified of which 12 trials with 14 arms were eligible. The amount of spirulina ranged from 1 to 19 g/d, and intervention durations ranged from 2 to 48 weeks. Overall, data synthesis showed that spirulina supplements significantly lowered total cholesterol (WMD = -36.60 mg/dL; 95% CI: -51.87 to -21.33;=0.0001), low-density lipoprotein cholesterol (WMD = -33.16 mg/dL; 95% CI: -50.52 to -15.75;=0.0002), triglycerides (WMD = -39.20 mg/dL; 95% CI: -52.71 to -25.69;=0.0001), very-low-density lipoprotein cholesterol (WMD = -8.02 mg/dL; 95% CI: -8.77 to -7.26;=0.0001), fasting blood glucose (WMD = -5.01 mg/dL; 95% CI: -9.78 to -0.24;=0.04), and DBP (WMD = -7.17 mmHg; 95% CI: -8.57 to -5.78;=0.001). These findings remained stable in the sensitivity analysis, and no obvious publication bias was detected.Conclusion: Our findings provide substantial evidence that spirulina supplementation has favorable effect on select cardiovascular and metabolic biomarkers in humans, including lipid, glucose, and DBP management.

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Spirulina maxima decreases endothelial damage and oxidative stress indicators in patients with systemic arterial hypertension. "IndyWatch Feed Health"

PMID:  Mar Drugs. 2018 Dec 8 ;16(12). Epub 2018 Dec 8. PMID: 30544795 Abstract Title:  Decreases Endothelial Damage and Oxidative Stress Indicators in Patients with Systemic Arterial Hypertension: Results from Exploratory Controlled Clinical Trial. Abstract:  (1) Background:()has shown beneficial effects such as being anti-dyslipidemic, antiviral, antioxidant and antihypertensive. However, there are few and limited clinical studies. (2) Methods: a prospective, randomized, parallel pilot study of 4.5 g administration ofor placebo for 12 weeks in 16 patients with systemic arterial hypertension (SAH) undergoing treatment with angiotensin-converting enzyme (ACE) inhibitors was performed to assess the effects on endothelial damage and oxidative stress indicators. The blood levels of sICAM-1, sVCAM-1, endothelin-1, and sE-selectin were quantified; the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and concentrations of reduced glutathione, oxidized glutathione, and thiobarbituric acid reactive substances, were also quantified before and after the treatment period. (3) Results: There were statistically significant (

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Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders. "IndyWatch Feed Health"

PMID:  Int J Mol Sci. 2018 Dec 13 ;19(12). Epub 2018 Dec 13. PMID: 30551559 Abstract Title:  Regulatory Efficacy ofProtease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats. Abstract:  Lipid metabolism disorder (LMD) is a public health a widely used natural weight-reducing agent andis a kind of protein source. In the present study, we aimed to evaluate the effect ofprotease hydrolyzate (SPPH) on the lipid metabolism and gut microbiota in high-fat diet (HFD)-fed rats. Our study showed that SPPH decreased the levels of triglyceride (TG), total cholesterol (TC), low-density-lipoprotein cholesterol (LDL-c), alanine transaminase (ALT), and aspartate transaminase (AST), but increased the level of high-density-lipoprotein cholesterol (HDL-c) in serum and liver. Moreover, SPPH had a hypolipidemic effect as indicated by the down-regulation of sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl CoA carboxylase (ACC), SREBP-1c, and peroxisome proliferator-activated receptor- (PPAR) and the up-regulation of adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor (PPAR) at the mRNA level in liver. SPPH treatment enriched the abundance of beneficial bacteria. In conclusion, our study showed that SPPH might beproduce glucose metabolic benefits in rats with diet-induced LMD. The mechanisms underlying the beneficial effects of SPPH on the metabolism remain to be further investigated. Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals.

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The effects of grounding (earthing) on bodyworkers' pain and overall quality of life. "IndyWatch Feed Health"

PMID:  Explore (NY). 2018 Oct 11. Epub 2018 Oct 11. PMID: 30448083 Abstract Title:  The effects of grounding (earthing) on bodyworkers' pain and overall quality of life: A randomized controlled trial. Abstract:  BACKGROUND: It is well known that massage therapists routinely develop a number of health problems related to their profession.PURPOSE: To determine the effects of grounding on massage therapists' quality of life and pain. Grounding, refers to being in direct body contact with the ground, such as walking barefoot on humid soil or on grass.SETTING: The Chopra Center for Well-Being in Carlsbad, California, USA.PARTICIPANTS: Sixteen massage therapists (mean age 42.8 years).RESEARCH DESIGN AND INTERVENTION: A stepped wedge cluster design was incorporated into a 6-week double-blind Randomized Controlled Trial (RCT) procedure with massage therapists assigned randomly into one of two cohorts. Therapists were not grounded for the first week, were grounded while working on clients and at home while sleeping for the next four weeks, and then ungrounded for the last week.OUTCOME MEASURES: Prior to, during, and immediately following the intervention, participants completed standardized questionnaires reporting on pain, physical function, anxiety, depression, fatigue/tiredness, sleep disturbance and number of hours of sleep, number of clients worked on per working day, energy, and emotional and mental stress.RESULTS: As a group, therapists experienced significant increases in physical function and energy and significant decreases in fatigue, depressed mood, tiredness and pain while grounded as compared to not being grounded. At one-month following the study, physical function was also increased and depressed mood and fatigue were decreased.CONCLUSIONS: We observed consistent beneficial effects of grounding in domains highly relevant to massage therapists, namely pain, physical function, and mood. These findings, combined with prior results from this trial indicating improvements in inflammatory biomarkers, blood viscosity and heart rate variability (HRV), suggest that grounding is beneficial to massage therapists in multiple domains relevant to their occupation, supporting overall health and quality of life.

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Effect of quercetin monoglycosides on oxidative stress and gut microbiota diversity in mice with dextran sodium sulphate-induced colitis. "IndyWatch Feed Health"

PMID:  Biomed Res Int. 2018 ;2018:8343052. Epub 2018 Nov 12. PMID: 30539022 Abstract Title:  Effect of Quercetin Monoglycosides on Oxidative Stress and Gut Microbiota Diversity in Mice with Dextran Sodium Sulphate-Induced Colitis. Abstract:  The pathogenesis of inflammatory bowel disease (IBD) is linked to an intricate association of environmental, microbial, and host-related factors. This study examined the potential effects of dietary addition of two preparations from onion, one comprising quercetin aglycone alone (Q: 0.15% polyphenols, quercetin aglycone:quercetin monoglycosides, 98:2) and another comprising quercetin aglycone with monoglycosides (Q+MQ: 0.15% total polyphenols, quercetin aglycone:quercetin monoglycosides, 69:31), on dextran sodium sulphate- (DSS-) induced colitis in mice. The results revealed a significant decrease in the body weight gain of the mice with DSS-induced colitis, which was counteracted by the dietary Q or Q+MQ supplementation. Meanwhile, the oxidative stress indicated by myeloperoxidase (MPO), reduced glutathione (GSH), malondialdehyde (MDA), and serum nitrate (NO) concentrations was higher in mice with DSS-induced colitis than in the control group mice, but dietary Q or Q+MQ supplementation counteracted this trend. The colitis mice demonstrated reduced Chao1, angiotensin-converting enzyme (ACE), and Shannon indices and an increased Simpson index, but the colitis mice receiving dietary Q or Q+MQ exhibited higher Chao1, ACE, and Shannon indices and a reduced Simpson index. In conclusion, this research showed that even at a low dose, dietary Q or Q+MQ supplementation counteracts DSS-induced colitis in mice, indicating that Q or Q+MQ may be used as an adjuvant therapy for IBD patients.

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What Do Crowd Control, Burning Skin, and Superbugs Have in Common? 5G "IndyWatch Feed Health"

Metal antenna symbol with letters 5G on white


What Do Crowd Control, Burning Skin, Your Street Corner, and Superbugs Have in Common?


The short answer: 5G networks, which are coming to your town. Action Alert!

Recently we told you how telecom companies are working with the federal government to eliminate local control over the deployment of 5G networks, which are billed as the next best thing in wireless technology. Recent research pointing to the health implications of 5G technology reinforces the need to have local control over how its used, but more importantly asks the question of whether we should hit the pause button altogether.

5G technology will make wireless networks capable of more data streaming at faster speeds because it uses a broader frequency spectrum, as explained here. Whereas current 4G networks use up to 6 GHz, 5G will use frequencies between 24 GHz and 100 GHz, known as millimeter-wave frequencies.

This means that the dozens of small cell towers that will be installed in your neighborhood will be emanating millimeter waves.

If that doesnt sound scary, consider this. The Department of Defense has developed a non-lethal crowd control device called the Active Denial System (ADS). The ADS works by firing a high-powered beam of 95 GHz waves at a targetthat is, millimeter wavelengths.  Anyone caught in the beam will feel like their skin is burning. The burning sensation stops once the target leaves the beam.

So, what were talking about with 5G technology is being exposed to the same kind of waves day in and day out, only at a...


FAN really needs your help today "IndyWatch Feed Health"

FAN really needs your help today and every day. When you think about it our campaign has only three things its workers (paid and unpaid), its supporters and its words ours and yours.

Our words. You, and all our other, precious supporters have read and heard them many times before. The science is on our side. That science even includes U.S. government funded studies. Fluoride has the potential to damage the brains of our children, in the womb and in every glass of water they drink. This practice must be ended.

Our words are stronger than ever but how do we get them to the people who need to hear them, when our governments will not listen, our professional bodies will not read and the media will not speak?

That brings us to our workers and supporters like you.

Our workers. We have put together a team (paid and unpaid) second to none. We have Ellen, the rock who keeps our web page and everything else going, Stuart our Campaign Director, Jay our Outreach and Education Director, Robin our Environment Justice Director, Carol our long-term and unpaid Media Officer, Chris Neurath our Science Director, Rick North our unpaid Advisory Counsel Chairperson, Jack Crowther our unpaid Editorial Advisor, our Science Advisers (Bill Osmunson, DDS, Bill Hirzy, PhD, Vyvyan Howard, MD,  David Kennedy, DDS, Neil Carmen, PhD, Bob Dickson, MD, James Beck, MD, PhD, Spedding Micklem, D.Phil (Oxon)  and so many more advisers) and wonderful volunteers and then there is our lawyer, Michael who has put together our exciting TSCA lawsuit, which will be heard this coming year.

I hope you agree that our team is doing a really great job on a limited budget (far smaller than many national organizations have let alone international organizations).

Our supporters.

You. You wouldnt be reading this bulletin if you were not one of our supporters. We need you and we need you in several ways.

Obviously we need your donations to keep our campaign going and over 200 of you have already generously donated and we thank you. It doesnt have to be a lot of money because we need to make the number our supporters visible and the only way we can do that is tally up the number of donors which we do every day.

We hope today and over the next few days before Christmas and before the end of the year, many more of you will make a tax-deductible donation towards our 2019 campaign.

But money is not everything.

We would like your help in another way. We need you to do what our governments, our professional bodies and the media are not doing.



Windsor council to debate putting fluoride back in water "IndyWatch Feed Health"

Council voted 8-3 to end fluoridation five years ago

Its been five years that Windsorites have lived without fluoride in their water. Now, council is headed back to city hall to debate whether they should put it back in.

The issue is expected to be a controversial one with 16 delegates lined up to speak, and 59 emails already received by the city clerk.

Many of the written delegations are from health-care associations and health-care professionals that want fluoride back in Windsors water.

According to the Oral Health 2018 report by the Windsor-Essex County Health Unit, the percentage of children with tooth decay or requiring urgent care has increased by 51 per cent in 2016-17 compared to 2011-12.

However, Mayor Drew Dilkens, who voted to have fluoride taken out, has not changed his stance.

Fluoride is one tool for good oral health, we all know that, but its not the only tool, he said.

Dilkens said fluoridated toothpaste is the number-one thing people can use to protect their teeth. He also suggested Healthy Smiles, the provincial program for low-income families to send their kids to receive free dental care.

Coun. Ed Sleiman is not so quick to reveal his stance. He voted to have fluoride taken out five years ago as well.

How could you please everyone? Thats the thing about it, he said.

We are kind of listening to both sides.

The money saved from stopping fluoridation has been diverted for oral health and nutrition education in the region.

If started again, Enwin Utilities estimates a one-time cost of $850,000, as the old equipment is no longer available for reuse. Ongoing costs would total roughly $105,000 to purchase the fluoride each year.

Mixed reviews

Some delegates wrote that they dont want fluoride in their water because they are worried about potential adverse health effects.

Parents are advised to contact poison control if their child swallows toothpaste containing fluoride, yet were going to be forced to allow it in our childrens daily water supply? wrote Deanna Latta from Amherstburg, wh...


Windsor City Council may reintroduce fluoride to water supply "IndyWatch Feed Health"

If an informal poll is any indication, Windsor city council will vote tonight to reintroduce fluoride into the drinking water supply. called or emailed all ten councillors Monday to find out what direction they are leaning; reintroduce fluoride five years after the council voted to remove it, or put it back in.

Six responded they would likely vote to reintroduce it. Four other councillors had not responded by publication.

In 2013, Ward 6 councillor Joanne Gignac was one of only three on council who voted against removing fluoride.

Ive kept a close eye on all the articles, all of the data, all of the medical research since then, and while Ill listen to hear if there is anything new being incorporated into the discussion tonight, I would have to say Im leaning towards reincorporating it, she said.

The only other two councillors to vote against removing it in 2013 were Ward 3s Fulvio Valentinis and Hilary Payne in Ward 9.

Even though the decision to remove it was made before he was elected to the council, Chris Holt in Ward 4 believed the debate never really went away.

Im fairly well versed, he said. [But] Im an auto worker Ive never gone to medical school. So, I have to lean on the opinions of the medical professionals that have been contacting me.

One of the most recent report from the Windsor-Essex County Health Unit shows tooth decay has increased, visits to emergency departments related to oral health cost the region $508,259, and a majority of residents support water fluoridation.

A report released last week shows that a quarter of residents do not have access to regular dental care.

Groups including the Essex County Dental Society, Ontario Oral Health Alliance, United Way Windsor-Essex, Canadian Association of Public Health Dentistry, Windsor-Essex Community Foundation, and the St. Leonards Society all express support for bringing fluoride back.

However, there is still also a great deal of opposition to reintroducing fluoride. Those against it argue it is unnecessary, can cause other health problems including lowered I.Q. and bone cancer, and should be left up to individuals to decide whether to ingest it.

In a bid to answer some of those concerns, and dispel some of the myths, the President of the American Fluoridation Society, Dr Johnny Johnson will speak to council.



Fox: Metal shavings found in toddlers intestines after eating Zarbees multivitamins which Johnson & Johnson acquired "IndyWatch Feed Health"

(Editors Note: This story is EVERYWHERE. Every mainstream news source is covering it, just in case you might doubt us.) Kansas mother Samantha Andersen has been using Zarbees Naturals Vitamins for years. The same Zarbees that was recently acquired by Johnson and Johnson (the same Johnson and Johnson whose shares recently plunged after a report came []

The post Fox: Metal shavings found in toddlers intestines after eating Zarbees multivitamins which Johnson & Johnson acquired appeared first on Health Nut News.


Pinterest bans Health Nut News for posting natural health information & vaccine safety info "IndyWatch Feed Health"

On December 13th, the hard work I put into my Pinterest page, which I had before I had even started my website and with its many thousands of followers- disappeared. Poof. It is gonein an instant: There are many other pages that have disappeared, I am not alone. For instance, our friends since the 80s, the National []

The post Pinterest bans Health Nut News for posting natural health information & vaccine safety info appeared first on Health Nut News.


Oh No! I Just Got Snoped! (Laugh Here) "IndyWatch Feed Health"

By Kent Heckenlively, JD After having my talk at the Commonwealth Club of California cancelled because of protests, being thrown out of Age of Autism for daring to pen a few articles for BolenReport, and being BANNED from speaking in Australia for three years, I have a new honor. Ive been Snoped! If you dont Continue reading Oh No! I Just Got Snoped! (Laugh Here)

The post Oh No! I Just Got Snoped! (Laugh Here) appeared first on BolenReport.


Newly-elected M.D. Member Of Congress To Challenge CDC About Fraudulent Vaccine Research & Data "IndyWatch Feed Health"

By Catherine J. Frompovich

The 116th United States Congress will convene sometime after January 3, 2019. One newly-elected member of the U. S. House of Representatives is a medical doctor from Tennessee, the former TN State Senator Mark Green, who has vowed to take on the CDC regarding fraudulently-handled data and research about vaccines and Autism.

According to Autism Action Network, who has an Action Alert about the issue, Dr. Green, a West Point graduate and a Bronze Star hero, intends to stand on the CDCs desk and get the real data on vaccines.

Dr. Mark Green put it this way:

Let me say this about autism. I have committed to my people in my community up in Montgomery County, to stand on the CDCs desk and get the real data on vaccines. Because there is some real concern that the rise in autism is the result of preservatives that are in our vaccines.

As a physician, I can make that argument and take a look at it academically and make the argument against the CDC, if they really want to engage me on it. But it appears that some of the data, honestly, has been fraudulently managed. So we got to go up there and stand against that and make sure we get that fixed.




This formula offers normal, healthy adrenal support for adults looking to give their body a quick acting liquid formula which will


Biologists Make Huge Vaccine Research Donation, Italian Scientists Angered "IndyWatch Feed Health"

Italian scientists are furious over a donation made by the countrys most influential biologist to a vaccine safety advocacy group. The vaccine safety group, Corvelva, opposes Italys controversial mandatory vaccination laws. The donation comes at a...

The post Biologists Make Huge Vaccine Research Donation, Italian Scientists Angered appeared first on Vaxxter.


Breaking news: New Jersey becomes first state to adopt a sweeping ban on wild animals in circuses "IndyWatch Feed Health"

This week, New Jersey Governor Phil Murphy and his state made history when he signed into law, a bill banning the use of numerous wild animal species, including elephants, tigers, lions, bears and primates, in circuses and traveling shows.1 The measure, which recognizes both the animal welfare concerns and the public safety dangers posed by such shows, []

The post Breaking news: New Jersey becomes first state to adopt a sweeping ban on wild animals in circuses appeared first on Health Nut News.


Holistic MD drops bombshell about 5G at legislation hearing "IndyWatch Feed Health"

In the video below, Dr. Sharon Goldberg, an internal medicine physician, former medical school assistant professor, and academic- with more than two decades in the field gives her testimony regarding electromagnetic radiation, 5G technology, and makes it clear that these topics should consume more of our leaders thoughts (industry-sponsored 5G wireless infrastructure legislation recently passed []

The post Holistic MD drops bombshell about 5G at legislation hearing appeared first on Health Nut News.


BIOSLUDGED: EPA allows spraying of highly toxic sewage sludge on food crops, documentary reveals "IndyWatch Feed Health"

(Thank you to our friends at Natural News for the story below.) Unbeknownst to the vast majority of Americans, the federal government has quietly given the green light for companies to take treated sewage and spread it all over Americas food crops as fertilizer. Its a form of recycling that the U.S. Environmental Protection Agency []

The post BIOSLUDGED: EPA allows spraying of highly toxic sewage sludge on food crops, documentary reveals appeared first on Health Nut News.


Detoxing from Vaccines, a doctors informative lecture "IndyWatch Feed Health"

With the world becoming increasingly toxic and the incredible lack of knowledge regarding appropriate healthcare, it has never been more important to take charge of your health and your life. And the way you do that is through education: RELATED STORY: Vaccine detoxes for adults We are very well aware of the fact that for some []

The post Detoxing from Vaccines, a doctors informative lecture appeared first on Health Nut News.


60 Minutes Reports on Detained Children Given Wrong Immunizations "IndyWatch Feed Health"

60 min w quote

What recourse does an immigrant family have if their children are vaccine injured while detained?   Not only were improper doses given, one mother in the report said her son was "changed" when they were reunited after 73 days.  Is the child suffering depression or trauma from the separation and/or vaccine injury that so many of us saw as our toddlers regressed and withdrew into autism?

Three-year-old Immers, the boy with the arrest warrant, was placed by the government with a foster family in Michigan for 73 days. This was his reunion with his mother.

She's saying, "I'm your mother honey, what is wrong with my son?"

In an interview, Gladys told us, "It felt like he wasn't my son anymore. It felt like a nightmare. Like I was dead."

She says, since detention, Immers has been withdrawn and moody.

"And from that day until today," Gladys said, "It's been very difficult to deal with him."
Separated at the border, a mother and child reunite

On the dosing errors:

Dr. Scott Allen: There was an episode where children in a mass immunization program were immunized with the wrong dose, adult dose instead of child dose, because the providers at the facility weren't used to working with children and didn't recognize some very common color coding that would denote adult versus pediatric vaccines.

They'd been writing reports of poor pediatric care in federal custody for four years when they heard that thousands more children were going to be cared for by the government, some...


Young People Are Being Prescribed Dangerous Antidepressants "IndyWatch Feed Health"

From The Guardian letters: I have been advised by colleagues in psychiatry that these drugs can raise young peoples energy level before they act to raise their mood, especially in the early months of use. This could lead to increasing the mindset and energy to carry out their dark thoughts, either harming themselves or others.

We wholeheartedly support the NICE guidelines recommendations that prescribing these drugs should be a last resort for children under 18 and not be used for those under the age of 10.


Your report is shocking. The two drugs most widely prescribed as first choice are paroxetine and venlafaxine, both SSRIs. These are powerful drugs, and the effect on developing brains is little researched. What little research there is suggests an increased risk of suicidal thoughts. But not only that, they are the two SSRIs with the most devastating withdrawal symptoms.



Is it time for a new classification system for scientific misconduct? "IndyWatch Feed Health"

Are current classification systems for research misconduct adequate? Toshio Kuroki special advisor to the Japan Society for the Promotion of Science and professor emeritus at the University of Tokyo and Gifu University thinks the answer is no. In a new paper in Accountability in Research, Kuroki who has published on research misconduct before Continue reading Is it time for a new classification system for scientific misconduct?


AlJazeera Series Questions WHO Infallability on Global Health "IndyWatch Feed Health"

Camels 3Note:  In the past years, it has become increasingly difficult to find an American news source that does not kowtow to Pharma. More recently, the vicious focus on politics, politicians and parties has made watching or reading the news almost impossible for me, personally. I was once politically active and tuned in. I've all but tuned out today.  Yesterday, I was seeking an update on the upheaval in France and tuned into BBC. American Sunday morning TV was nothing but a nasty tennis match. Here's an interesting report from AlJazeera on the World Health Organization, that points out the Swine Flu scare and vaccine purchases that enriched global pharma companies.  JB Handley's book How to End the Autism Epidemic also delves into using what we now call "tobacco [bought] science" to promote vaccination.


Trust WHO: The Business of Global Health

Investigating the hidden motives behind actions of the World Health Organisation and the real powers that control it.

Headquartered in Geneva, Switzerland, the WHO is now 7,000 employees strong, with six regional offices and 150 country offices around the world, and over 194 member states adhering to the regulations released by the organisation as per the United Nations system.

Whether it's the effects of smoking, the swine flu pandemic or a nuclear disaster, the WHO is the body we rely on to advise on and resolve a public health crisis. But can it be trusted? How does the WHO decide on its recommendations? And how reliable are they?

Trust in the WHO's ability to objectively address global health matters is not as strong as it may have been at its inception. And concerns regarding the organisation's finances and the influences of independent contributors have been circulating since the 1950s when, after years of inaction, the WHO's relationship with key players in the tobacco industry came to light.

"The tobacco industry founded institutes and bought scientists who would represent their position and they made sure their own names didn't appear anywhere," says former secretary of health of Switzerland, Thomas Zeltner. "So the organisations were called things that wouldn't make you suspect they were really representing the tobacco industry."

Scientists and other important figures within these institutes would often have links to both tobacco giants and the WHO,...


This popular treatment is deadly, doctors repeatedly proven wrong "IndyWatch Feed Health"

In the featured podcast, Dr. Peter Attia interviews professor Thomas Seyfried, Ph.D., recipient of our Game Changer Award in 2016 for his work on cancer as a metabolic disease, which is also the title of Seyfrieds book on this topic. His work is also heavily featured in Travis Christoffersons excellent book, Tripping Over the Truth: []

The post This popular treatment is deadly, doctors repeatedly proven wrong appeared first on Health Nut News.


Proven Uses and Benefits of Peppermint Oil (Peppermint Essential Oil) Backed by Medical Studies "IndyWatch Feed Health"

Peppermint essential oil is a cooling and soothing essential oil that has many health benefits. You can use the antimicrobial and antispasmodic properties of peppermint oil to relieve digestive complaints, get rid of cold symptoms, boost hair growth, and treat toothache. Peppermint oil is also good to rub on sore joints to help relieve pain and inflammation.

There are many different ways that you can use peppermint oil for its health benefits. Peppermint oil can be used with a carrier oil to apply topically. Or, you can put a few drops of peppermint essential oil to use in your diffuser for inhalation. For digestive complaints, you can buy peppermint oil capsules to help relieve stomach upset and excess gas.

In this article, you will learn about what science says as to the many uses of peppermint oil. You will also find practical ways to use peppermint oil for headaches, heartburn, improved performance, and better cognitive function.

What Is Peppermint Oil (Peppermint Essential Oil)?

Peppermint essential oil is an antimicrobial oil that is extracted by distillation from the leaves and flowers of the Mentha x piperita plant (Peppermint).

The National Center for Complementary and Integrative Health says that peppermint is a herb that is a cross of water mint and spearmint. Peppermint oil has been used for centuries to treat various ailments. (1)

Research into the composition of peppermint oil shows that it is made up of various volatile oils. The main compounds that give peppermint oil its cooling and therapeutic properties are menthol and menthone. Peppermint essential oil also contains antioxidant properties. (2)

Peppermint oil is used topically to soothe headaches, muscle and joint pain, and orally to alleviate digestive complaints. Using peppermint oil in recommended dosages rarely causes any adverse effects. (3)

Many people describe the taste of peppermint oil as a sharp minty, cool taste that refreshes your mouth. Spearmint has a milder taste to peppermint as there is less menthol in the plant.

The difference between peppermint extract and peppermint oil is that peppermint extract is usually obtained in an alcohol solution and is not as concentrated as peppermint essential oil.

What Peppermint Oil Is Good for (Peppermint Essential Oil Uses)

Peppermint oil is a commonly-used essential oil that has many uses as an antibacterial, antifungal, antispasmodic and pain-relieving remedy.

There are many scientific studies that back up th...


Five of the Top Six Fruits and Vegetables Eaten in the U.S. are Highly Contaminated with Toxic Pesticides "IndyWatch Feed Health"


five of top six toxic

Both tomatoes and potatoes made the list of top U.S. vegetables that also happen to be contaminated.






Can Drinking Okra Water Help Fight Diabetes? "IndyWatch Feed Health"

According to research, extracts from okra could help offset damage done by oxidative stress and insulin resistance, and simultaneously improve your blood glucose levels. Those results were attained when scientists tested okra extracts on pregnant rats with induced gestational diabetes mellitus (GDM).

During the featured study on rats from 2015,1 scientists found okra extract exerted potential antihyperglycemic and hypolipidemic effects. The okra was also associated with reduced damage to pancreatic tissues. In a recent study,2 researchers concluded that okra may improve glucose homeostasis and -cell (beta cells that produce, store and release insulin3) impairment in diabetes.

Okra, you may know, is a vegetable known as a favorite in the American south for dishes like Creole-style gumbo. The Abelmoschus esculentus (okra) plant, also known as Hibiscus esculentus (being related to the hibiscus plant, as well as cotton), is also called lady fingers because it produces several tapering, pentagon-shaped, fuzzy pods with pointed tips and lots of compartmentalized seeds.4

As an ancient, flowering plant with origins all over the world, okra has several more names: gombo, bamia or bamya in France; bhindi in India, quibombo in Spain and simply "bamies" in the Mediterranean and Middle East. It was probably brought to the Southern U.S. by slaves from West Africa, who often used it to thicken soups.5 In fact, this plant does require balmy temperatures to thrive.

The seedpods are the part of the plant with the most gastronomical interest. As Cooking Channel TV maintains, they can be barbecued, pickled, skewered and grilled, or sauted. It doesn't have to be doused in canola or some other "vegetable" oil, coated with flour and deep-fried; you can use healthy ingredients:

"Gumbo is nothing without the okra that breaks down and helps thicken the stew Okra is often paired with acidic flavors like lemon juice or tomatoes to balance out the earthy, woody flavors Yankee Okra, or okra sauted in olive oil with garlic, crushed red pepper, thyme and basil, pairs the flavors you know and love with an ingredient that you will soon be familiarizing yourself with."6


Weekly Health Quiz: Cholesterol and Life Expectancy "IndyWatch Feed Health"

1 For optimal health and prevention of cardiovascular disease and neurological degeneration, you'll want to maintain the following ratio of omega-3 to omega-6:

  • 1-to-18
  • 1-to-3

    While omega-3s have an anti-inflammatory effect, the omega-6 found in seed oils tend to be proinflammatory. Maintaining a healthy 1-to-3 ratio of omega-6 to omega-3 is important, as chronic low-grade inflammation is a hallmark of most chronic diseases, including obesity, diabetes and heart disease. Learn more.

  • 1-to-6
  • 1-to-1

2 Which of the following is more likely to kill a person than being unvaccinated and contracting the childhood diseases rubella, mumps or rotavirus in childhood?

  • Slipping in the shower
  • A lightning strike
  • Choking on food
  • All of the above

    Before vaccines became available and were routinely used, the annual death toll in the U.S. from rubella was 17 to 24, rotavirus 20 to 30 and mumps 39 to 50. For comparison, each year 100 people die from being struck by lightning, 200 die from choking on food, 350 die from slip and fall accidents in the bath or shower. Learn more.

3 The most significant risk factor for cardiovascular disease is:

  • High total cholesterol
  • High LDL
  • High HDL
  • ...

Essential Oils Highly Effective at Destroying Lyme Bacterium "IndyWatch Feed Health"

Lab-based research conducted at Johns Hopkins School of Public Health suggests various essential oils, including garlic, can effectively kill persistent forms of Lyme disease bacterium. While clinical trials are needed to validate the lab-based results, this is good news for anyone who had previously been relying on antibiotics alone to treat this life-threatening, tick-based disease.

Notably, 10 of the 35 essential oils tested showed strong killing activity against dormant and slow-growing "persister" forms of Lyme disease bacterium.1

If you are struggling with Lyme disease, I encourage you to look beyond conventional treatment, which often focuses on the use of long-term antibiotics. You owe it to yourself to investigate essential oils and other natural solutions, which I highlight below.

Essential Oils Shown To Be Effective for Treating Lyme Disease

As presented in the featured video, a new study published in the journal Antibiotics2 suggests essential oils such as garlic and eucalyptus may be useful in treating Lyme disease.

Interested in the oils strong antibacterial properties and many other health benefits, a team of researchers from the Johns Hopkins School of Public Health conducted lab tests designed to treat Lyme bacterium with 35 essential oils.

Previously, lead study author Dr. Ying Zhang, professor in the department of molecular microbiology and immunology, and his colleagues identified five essential oils, including oregano, cinnamon bark and citronella, that have higher antipersister activity than the commonly used Lyme antibiotic drug daptomycin.3 Results of the current research revealed:4,5,6

  • Ten of the 35 essential oils that were tested showed "strong activity" against persister forms of Lyme disease bacterium
  • Essential oils derived from allspice berries, cinnamon bark, cumin seeds, eucalyptus, garlic cloves, myrrh trees and thyme leaves are among those found to effectively combat persister forms of Lyme disease
  • Five of these oils were effect...

Protein in Royal Jelly Shows Promise in the Facilitation of Stem Cell Research "IndyWatch Feed Health"

Aside from being vital pollinators, bees produce a number of products that benefit human health. Honey1 is an obvious one, but there are others as well, such as royal jelly, a nutritious substance secreted by nurse bees as exclusive nourishment for the queen of the hive.

Recent research2,3,4,5 by Stanford University scientists found royalactin (also known as major royal jelly protein 1, or MRJP1), a protein found in royal jelly responsible for the queen's massive growth, has the ability to keep embryonic stem cells pluripotent.

This initial finding could eventually lead to the development of drugs to boost stem cells in the human body, allowing for the regeneration of healthy tissue in damaged organs, be it your heart, eyes, skin or spinal cord.

They also identified a protein with similar qualities found in mammals, which they dubbed Regina a nod to the queen bee for which royalactin is made which like royalactin allows embryonic stem cells to maintain their nave state. According to the authors:

"This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species."

Researchers Discover Innate Program for Stem Cell Self-Renewal

Embryonic stem cells are the product of the initial meeting of egg and sperm. Three days after fertilization of the egg, an inner cell mass can be isolated, and these are the embryonic stem cells that, if left alone, will grow into a fetus.

Stem cells are pluripotential, meaning that they have the ability to turn into any and every type of tissue to form an entire being, be it animal or human. Adult stem cells, in contrast, are multipotential, meaning they only have the ability to form subsets of tissue.

The problem researchers have is that embryonic stem cells have a tendency to differentiate into mature tissue cells of various kinds when grown in the lab, and in order to use the stem cells for research and/or therapies, they must be kept in their "nave" state long enough. As explained by New Atlas:6

"With the ability to differentiate into all kinds of cells that serve specialized functions, like muscle cells, red blood cells or brain cells, embryonic stem cells have incredible potential. But growing them in the laboratory is difficult, because their natural inclination is to quickly...


Ameliorative effects of quercetin against bisphenol A-caused oxidative stress in human erythrocytes. "IndyWatch Feed Health"

PMID:  Toxicol Res (Camb). 2018 Nov 1 ;7(6):1091-1099. Epub 2018 Aug 22. PMID: 30542603 Abstract Title:  Ameliorative effects of quercetin against bisphenol A-caused oxidative stress in human erythrocytes: anand. Abstract:  Bisphenol A (BPA) is an endocrine disruptor of xenobiotic type, mainly used for the production of polycarbonate plastic, epoxy resins and non-polymer additives. Because of its wide usages in the environment, the toxic effects of BPA have proved to be harmful to human health. However, its effects on human haemoglobin remain unclear. The affinity between BPA and haemoglobin, as well as erythrocytes, is an important factor in understanding the mechanism of the toxicity of BPA. Flavonoids are strong antioxidants that prevent oxidative stress and Quercetin is a flavonoid found in numerous vegetables and fruits. Therefore, the present investigation was undertaken to investigate whether Quercetin can be used to alleviate the toxic effects of BPAin human red blood cells (RBC). Venous blood samples were collected from healthy, well-nourished adult volunteers (25-30 years old) by phlebotomy. In a RBC suspension with a cell density of 2 104 cell per mL, the concentration of BPA (25-150 g mL) was found to cause an increase in the lipid peroxidation (LPO) and a decrease in the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) in human RBC. However, the concurrent addition of BPA (150g mL) and quercetin (10-50g mL) lead to significant amelioration.studies gave structural insight into BPA and quercetin to decipher the plausible binding mechanism and molecular level recognition.

read more


Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss. "IndyWatch Feed Health"

PMID:  FASEB J. 2018 Oct 4:fj201800920R. Epub 2018 Oct 4. PMID: 30285579 Abstract Title:  Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling. Abstract:  Postmenopausal osteoporosis is initiated by estrogen withdrawal and is characterized mainly by overactivated osteoclastic bone resorption. Targeting TNF receptor-associated factor 6 (TRAF6) or its downstream signaling pathways to modulate osteoclast formation and function is an appealing strategy for osteoclast-related disorders. In the present study, we determined the effect of tomatidine, a steroidal alkaloid derived from Solanaceae, on the formation and function of receptor activator of NF-B (RANK) ligand-induced osteoclasts and the underlying mechanism. Tomatidine inhibited osteoclast formation in a dose-dependent manner and decreased the expression of osteoclast marker genes. Actin ring formation and osteoclastic bone resorption were attenuated in the presence of tomatidine in vitro. Eight weeks after ovariectomy, tomatidine prevented estrogen deficiency-induced bone loss and restored the mechanical properties of the femur. At the molecular level, tomatidine abrogated phosphorylation of c-Jun N-terminal kinase (JNK)/p38, NF-B, and protein kinase B (Akt) pathway proteins bysuppressing RANK expression, inhibiting the binding of TRAF6 to RANK, and downregulating the osteoclastogenesis marker-related protein expression. In summary, these data demonstrated that tomatidine attenuated osteoclast formation and function by modulating multiple TRAF6-mediated pathways. Therefore, tomatidine could be a novel candidate for the treatment of osteoclast-related disorders, including osteoporosis.-Hu, B., Sun, X., Yang, Y., Ying, Z., Meng, J., Zhou, C., Jiang, G., Li, S., Wu, F., Zhao, X., Zhu, H., Wu, H., Cai, X., Shi, Z., Yan, S. Tomatidine suppresses osteoclastogenesis and mitigates estrogen deficiency-induced bone mass loss by modulating TRAF6-mediated signaling.

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Tomatidine could be a candidate for the treatment of dengue given its potent antiviral activity. "IndyWatch Feed Health"

PMID:  Antiviral Res. 2018 Nov 22 ;161:90-99. Epub 2018 Nov 22. PMID: 30468746 Abstract Title:  Tomatidine, a novel antiviral compound towards dengue virus. Abstract:  Dengue is the most common arboviral disease worldwide with 96 million symptomatic cases annually. Despite its major impact on global human health and huge economic burden there is no antiviral drug available to treat the disease. The first tetravalent dengue virus vaccine was licensed in 2015 for individuals aged 9 to 45, however, most cases are reported in infants and young children. This, together with the limited efficacy of the vaccine to dengue virus (DENV) serotype 2, stresses the need to continue the search for compounds with antiviral activity to DENV. In this report, we describe tomatidine as a novel compound with potent antiviral properties towards all DENV serotypes and the related Zika virus. The strongest effect was observed for DENV-2 with an EC50 and EC90 value of 0.82 and 1.61M, respectively, following infection of Huh7 cells at multiplicity of infection of 1. The selectivity index is 97.7. Time-of-drug-addition experiments revealed that tomatidine inhibits virus particle production when added pre, during and up to 12h post-infection. Subsequent experiments showthat tomatidine predominantly acts at a step after virus-cell binding and membrane fusion but prior to the secretion of progeny virions. Tomatidine was found to control the expression of the cellular protein activating transcription factor 4 (ATF4), yet, this protein is not solely responsible for the observed antiviral effect. Here, we propose tomatidine as a candidate for the treatment of dengue given its potent antiviral activity.

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Co-encapsulation of EGCG and quercetin in liposomes for optimum antioxidant activity. "IndyWatch Feed Health"

PMID:  J Food Sci. 2018 Dec 12. Epub 2018 Dec 12. PMID: 30548488 Abstract Title:  Co-Encapsulation of EGCG and Quercetin in Liposomes for Optimum Antioxidant Activity. Abstract:  Although different delivery systems have been developed to overcome the limits of Epigallocatechin-3-gallate (EGCG) and quercetin in food application, none have referred to their simultaneous encapsulation. In this study, these two polyphenols were successfully co-loaded into liposomes. Under the optimal conditions (lecithin-total polyphenols ratio 25:1, lecithin-cholesterol ratio 6:1, lecithin-Tween 80 ratio 8:1 and ultrasonic time 2 min), the mean size, polydispersity index (PDI) and zeta potential of liposomes were 111.10 0.52 nm, 0.259 0.006 and -19.83 0.45 mV, with an encapsulation efficiency of 64.05 1.56% and 61.73 2.55% for EGCG and quercetin, respectively. After 30-day storage, an increase of 4.05% was observed in the mean size with no significant change (P 0.05) in the PDI and zeta potential. Moreover, 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay revealed a synergistic antioxidant effect of the two compounds in liposomal system. These results demonstrated that co-encapsulation of EGCG and quercetin enhances their effectiveness. PRACTICAL APPLICATION: EGCG and quercetin are natural polyphenols abound in the human diet with diverse biological activities. These two polyphenols were successfully co-encapsulated into a homogeneous and stable liposomal system. Interestingly, a synergistic antioxidant effect of the two polyphenols was observed due to co-encapsulation. This indicated thatthe simultaneous delivery of EGCG and quercetin was an attractive approach to improve their functionality for expanding their application in food, cosmetic and pharmaceutical industries.

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A review of the in vitro and in vivo evidence that quercetin protects against diabetes and its complications. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2019 Jan ;109:1085-1099. Epub 2018 Nov 6. PMID: 30551359 Abstract Title:  In vitro and in vivo evidence that quercetin protects against diabetes and its complications: A systematic review of the literature. Abstract:  Quercetin, a typical flavonoid, possesses diverse biochemical and physiological actions, including antiplatelet, estrogenic, and anti-inflammatory properties. This review mainly centers on recent ten years findings with respect to intervening diabetes and its complications with the well-known flavonoid quercetin. After a short introduction of quercetin, major in vitro and in vivo findings are summarized showing that quercetin is a promising molecule for the treatment of these diseases. Finally, we contemplate future development and application prospects of quercetin. Despite the wealth of in animal research results suggesting the anti-diabetic and its complications potential of quercetin, its efficacy in diabetic human subjects is yet to be explored. The problem may become an important direction in the future research.

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A significant reduction in blood glucose and HbA1c levels was observed in rats treated with resveratrol or mangiferin. "IndyWatch Feed Health"

PMID:  J Diet Suppl. 2018 Jul 9:1-17. Epub 2018 Jul 9. PMID: 29985711 Abstract Title:  Effects of Resveratrol and Mangiferin on PPAR and FALDH Gene Expressions in Adipose Tissue of Streptozotocin-Nicotinamide-Induced Diabetes in Rats. Abstract:  Type 2 diabetes (T2D) is characterized by insufficient insulin secretion by the pancreatic beta cells and insulin resistance in liver, skeletal muscle, and white adipose tissue. Adipose tissue plays a major role in glucose homeostasis and lipid metabolism. Dietary antioxidants such as resveratrol and mangiferin may offer some protection against the early stage of diabetes mellitus. Therefore, an attempt has been made to investigate the effects of resveratrol and mangiferin on biochemical parameters and molecular mechanism of PPAR and FALDH gene expression in adipose tissue of streptozotocin- (STZ-) nicotinamide- (NA-) induced diabetic rats. Albino Wister rats were randomly divided into five groups: control rats (Group 1), diabetic control rats (Group 2), diabetic rats given resveratrol (40 mg/kg body weight per day; Group 3), diabetic rats given mangiferin (40 mg/kg body weight per day; Group 4), diabetic rats given glibenclamide (0.6 mg/kg body weight per day; Group 5). Serum biochemical parameters-total cholesterol (TC), total triglyceride (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, glycosylated hemoglobin (HbA1c), urea, and uric acid were analyzed. We found that the oral administration of resveratrol and mangiferin to STZ-NA-induced diabetic rats for 30 days showed the significant protective effect on all the biochemical parameters. A significant reduction in blood glucose and HbA1c levels was observed in rats treated with 40 mg/kg body weight per day of resveratrol or mangiferin. Moreover, both these antioxidants showed significant enhancement of PPAR and FALDH gene expression in rat adipose tissue compared to control rats.

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A mini-review of therapeutic potential of Mangifera indica L. "IndyWatch Feed Health"

PMID:  Pak J Pharm Sci. 2018 Jul ;31(4):1441-1448. PMID: 30033432 Abstract Title:  Mini-Review- A mini-review of therapeutic potential of Mangifera indica L. Abstract:  Among known species of 69 Mangifera, Mangifera indica L. is a medicinal plant being used in tropical regions by indigenous people. It has been a main plant species being used in Ayurvedic as well as indigenous medical systems form 4000 years. Components of M. indica are recurrently used as a traditional medicine system to cure numerous ailments. Active constituents are present in stem bark, leaves, heartwood, roots and fruit and have antioxidant, anti-inflammatory, radioprotective, antitumor, immune-modulatory, anti-allergic, anti-diabetic, anti-bone resorption, mono-amine oxidase inhibiting, anti-viral, anti-fungal, anti-bacterial, anti-spasmodic, antidiarrheal, anti-malarial, antiparasitic as well as lipolytic properties. In spite of essential progress in phyto-chemical and medicinal analysis of M. indica, more efforts are needed to explore M. indica active components and their application in pharmaceutical industry. In this review, we focus on recent information about chemical constituents and pharmacological uses of M. indica.

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The study also highlights mangiferin as a promising Wnt inhibitor for liver cancer treatment. "IndyWatch Feed Health"

PMID:  Cell Physiol Biochem. 2018 ;47(5):1819-1834. Epub 2018 Jun 28. PMID: 29953980 Abstract Title:  Repression of WT1-Mediated LEF1 Transcription by Mangiferin Governs-Catenin-Independent Wnt Signalling Inactivation in Hepatocellular Carcinoma. Abstract:  BACKGROUND/AIMS: The development of hepatocellular carcinoma (HCC) is a complex process which involves deregulation of multiple signalling pathways. The hyper-activation of Wnt signalling promotes sustained expansion, invasion, and neovascularization of HCC. Mangiferin, a natural small molecule present in Mangifera indica L. has been shown to inactivate-catenin, which is an indispensable regulator in Wnt pathway. Our study aimed to determine whether mangiferin has any inhibitory effect on HCC and examine how it modulates Wnt signalling.METHODS: The tumour inhibitory effect of mangiferin was examined by in vitro cellular models and an in vivo orthotopic HCC implantation model. The genes responsible for mangiferin-mediated anti-HCC were delineated by polymerase chain reaction (PCR) microarray. The expression of target genes was further determined by quantitative PCR and immuno-blotting assays. The binding capacity of Wilms' tumour 1 (WT1) to the lymphoid enhancer-binding factor 1 (LEF1) promoter was confirmed by chromatin immunoprecipitation-qPCR.RESULTS: Oral administration of mangiferin inhibited orthotopic tumour growth. Cellular investigations confirmed the dose-dependent inhibition of mangiferin on HCC expansion and invasion. PCR array combined with Gene Ontology analysis revealed that the Wnt pathway was the predominant target of mangiferin and LEF1 was the most reduced gene in the Wnt pathway. Overexpression of LEF1 diminished repression of Wnt signalling and reduced proliferation activity in mangiferin-treated HCC cells. The mangiferin-mediated down-regulation of LEF1 was independent of-catenin but associated with WT1 protein. WT1 knock-in in HCC cells further enhanced LEF1 expression. Chromatin immunoprecipitation assays revealed that the mangiferin induced repression of LEF1 was associated with decreased occupancy of WT1 on the LEF1 promoter.CONCLUSION: Our study identifies a novel mechanism of hepatocellular carcinoma inhibition through-catenin-independent Wnt signalling, which is regulated by WT1-associated LEF1 repression. The study also highlights mangiferin as a promising Wnt inhibitor for HCC treatment.

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M. indica leaf aqueous extract alleviates the harmful effect of carbon tetrachloride-induced hepatic damage. "IndyWatch Feed Health"

PMID:  J Pharm Biomed Anal. 2018 Oct 21 ;164:112-118. Epub 2018 Oct 21. PMID: 30368116 Abstract Title:  Restorative activity of aqueous extract Mangifera indica leaves against CClinduced hepatic damage in rats. Abstract:  Hepatic diseases remain problematic throughout the world. There are no drugs that completely restore hepatic capacity and help to regenerate liver cells. Therefore, the present examination was intended to investigate the hepatoprotective impacts of Mangifera indica (M. indica) leaf aqueous extract at two doses (200 and 400mg/kg body weight (bw) for 6 weeks. Liver damage was induced by CCland the extent of damage was measured by body weight gain, feed efficiency, and liver index, and by assessing hematological, biochemical parameters, and liver histology. Results show that phytochemical analysis revealed the presence of important phytochemicals like flavonoids, phenols, steroids, glycosides, saponins and terpenoids. Also, aqueous extract of M. indica showed that the total phenolic contents (86.202.6g GEA/mg),flavonoid contents (42.643.1g QE/mg) and antioxidant activities (DPPH) were 92.584.1. The 50% inhibitory concentration (IC50) was 0.467gml. CClcaused a significant decrease in food intake, weight gain, feed efficiency ratio, and liver index, and also in the serum protein, albumin, globulin, high-density lipoprotein (HDLc), and CAT levels. CClalso caused an increase in serum AST, ALT, total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDLc), very low-density lipoprotein (VLDLc), and MAD. However, treatment with M. indica revealed attenuation of liver function, serum biomarker levels that had been increased by chronic CClintoxication. M. indica (400mg/kg of bw) showed a greater reduction in the biomarker levels compared with M. indica (200mg/kg of bw) and silymarin. These results were supported by histopathological examination of liver sections. Collectively, this study indicates that M. indica leaf aqueous extract alleviates the harmful effect of CCl-induced hepatic damage.

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The effect of ethanolic extract of S. indicum was found to be equivalent to methotrexate and greater than diclofenac. "IndyWatch Feed Health"

PMID:  J Tradit Complement Med. 2018 Jul ;8(3):377-386. Epub 2017 Jul 5. PMID: 29992108 Abstract Title:  Anti-rheumatoid activity of ethanolic extract ofseed extract in Freund's complete adjuvant induced arthritis in Wistar albino rats. Abstract:  one of the first recorded plants used for its seeds, is reported to have analgesic, antioxidant, anticancer, anti-obesity as well as hepato and nephro protective activities. The current study evaluated the effects of two doses (400 and 800 mg/kg) of ethanolic extract of.seeds in Freund's complete adjuvant induced arthritis in rats in comparison with diclofenac and methotrexate by the changes produced in body weight, body temperature, paw volume and spontaneous activity, hemoglobin, erythrocyte sedimentation rate, total white blood cells, red blood cells, Interleukin-6 and Tumor necrosis factor- as well as joint changes in X-ray and histological changes in joint tissue. Unlike the untreated group, the groups treated with.showed significant decrease in paw volume, body weight, white blood cell count, erythrocyte sedimentation rate, Interleukin-6 and Tumor necrosis factor- and an increase in body weight, spontaneous activity, hemoglobin level, and red blood cell count. Histopathological examination showed gross reduction in synovial inflammation and cartilage damage. X-ray revealed significant improvement in joint space. The effect of ethanolic extract of.was found to be equivalent to methotrexate and greater than diclofenac.

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Scientifically Proven Benefits and Uses of Lemon Oil (Lemon Essential Oil) "IndyWatch Feed Health"

Lemon essential oil is a fresh aromatic oil that is good for your skin, improving your brain health, boosting digestion, and invigorating you. To get the health benefits of lemon oil, you can dilute it with a carrier oil to massage onto your skin. You can also use lemon essential oil in a diffuser to inhale its refreshing scent and boost your mood.

Lemon, of course, is a very a healthy fruit full of vitamin C. It seems that the benefits of lemon essential oil are just as many as consuming fresh lemons. Lemon oil contains beneficial compounds that have antioxidant, antimicrobial, and anticancer properties.

As well as lemon essential oil being good to put on your skin, you can add it to water. All you need to do is put a drop or 2 of lemon oil in a glass of drinking water.

In this article, you will learn what science says as to the many reasons to use lemon oil for your health. You will also find out practical ways to use lemon essential oil to improve your skin, get rid of acne, energize your mind, and improve your digestive health.

What Is Lemon Oil (Lemon Essential Oil)?

Lemon essential oil is usually extracted from lemons (botanical name Citrus limon) using a steam distillation method. Lemon oil is also derived by cold-pressing the lemon peel which is full of goodness. This produces a zesty essential oil that has a distinct lemon smell to it.

Research into the benefits of lemon essential oil has found that its main components are limonene and beta-Pinene. These compounds have a powerful antioxidant activity that helps keep you healthy. Lemon essential oil also contains antimicrobial compounds that kill many germs. (1)

There are various types of extracts apart from lemon essential oil that also have health benefits. For example, lemon extract is usually made by placing lemon peel in alcohol to extract the goodness. Or, you can also buy lemon seed oil.

In this article, I will concentrate on the many beneficial uses for lemon essential oil.

What is Lemon Oil (Lemon Essential Oil) Good For?

The medicinal compounds in lemon essential oil mean that lemon oil has many uses when it comes to your health.

Research published in the International Journal of Molecular Sciences in 2018 confirmed why lemon oil has been used for its therapeutic benefits for centuries. Among some of the reasons why lemon essential oil is good for you, scientists noted some of the following: (2)

  • Lemon oil has carm...


Lavender Oil: Uses and Benefits for Hair, Skin, and More (Science Based) "IndyWatch Feed Health"

Lavender essential oil is a popular oil that can help to keep your skin and hair looking healthy. Lavender oil has many uses that include relieving stress, getting rid of headaches, soothing pain, and killing off germs from your skin. You can also use lavender essential oil to treat dandruff or athletes foot due to its antifungal properties.

One of the reasons why lavender oil is such a popular essential oil is that it is one of the most versatile healing oils. The antimicrobial properties and pleasant scent of lavender oil mean that you can use it with carrier oils to treat many ailments. Lavender oil is also delicate enough to use directly on your skin as a spot treatment.

In this article, you will learn about the many uses of lavender oil. You will find out what science says as to why lavender essential oil is good for your skin, hair, and mind.

What Is Lavender Oil (Lavender Essential Oil)

Lavender essential oil is extracted from flowers of the lavender plant (Lavendula angustifolia). People have used lavender extracts for centuries due to its medicinal properties.

Lavender oil contains chemicals that are known to have a positive effect on the mind and your general well-being.

Studies into the composition of lavender reveal that lavender contains volatile oils such as linalool, linalyl acetate, lavandulyl acetate, and camphor. (1) These oils are extracted using a distillation method that can affect the yield and composition of lavender essential oil. (2)

Lavender essential oil has a very floral and recognizable scent with a distinct camphor smell to it. Researchers say that the smell of linalool in lavender is a pleasant smell that induces calmness and enhances sleep. (3)

Unlike most essential oils, you can put a drop or two of lavender oil directly on your skin as a spot treatment. In fact, the journal Cell Proliferation reports that lavender is one of the mildest essential oils that are good for your skin. (4)

To use lavender oil on larger areas of skin, you should dilute lavender oil in a carrier oil. Some of the carrier oils you can use for diluting lavender oil are olive oil, sweet almond oil, coconut oil, or...


Red bean extract inhibits the expressions of transcription factors associated with adipocyte differentiation in a dose-dependent manner. "IndyWatch Feed Health"

PMID:  Food Sci Biotechnol. 2018 Dec ;27(6):1811-1821. Epub 2018 Jul 7. PMID: 30483446 Abstract Title:  Repressive effects of red bean,extracts on obesity of mouse induced with high-fat diet via downregulation of adipocyte differentiation and modulating lipid metabolism. Abstract:  Obesity is generally caused by quantitative changes in adipocyte differentiation and fat metabolism. Only a few studies have been determined the effect of red beans extract on obesity and plasma cholesterol concentration. We have been studied the functional activities of red-bean extracts including anti-oxidative effect against DNA and cell damages. Histological study including micro CT analysis showed that the accumulation of fat in hepatocytes and intestines was significantly decreased in red bean extract treated group. In addition, plasma cholesterol and triglyceride levels were decreased in blood samples. In addition, it was confirmed that the red bean extract inhibited the expression of PPAR, Fabp4 and RETN genes, which regulate total adipocyte differentiation and lipid metabolism. Red bean extract inhibits the expressions of transcription factors associated with adipocyte differentiation in a dose-dependent manner, thereby inhibiting fat accumulation and decreasing blood lipid levels in obese mice induced by high fat diet.

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Rosemary (Essential) Oil: Benefits and Uses for Hair, Skin and More (Science Based) "IndyWatch Feed Health"

Rosemary essential oil is a fragrant oil that is good for improving your brain function, enhancing memory, coping with stress, and relieving pain. The pleasant aroma of rosemary oil does wonders to boost your mood and enhance feelings of calm. Rosemary essential oil can also be used topically to promote hair growth, relieve muscle pain, and improve the appearance of your skin.

Rosemary oil and rosemary extracts have been used for centuries due to their medicinal properties. Scientific research now backs up many of the therapeutic uses of rosemary essential oil. In fact, research has shown that rosemary oil contains high levels of powerful antioxidants.

In this article, you will learn about the many rosemary oil uses and benefits for your health. You will also find out practical ways to use rosemary oil for its therapeutic benefits.

What Is Rosemary?

Rosemary (botanical name Rosmarinus officinalis) is an evergreen herb that gives off a pleasant woody scent.

Rosemary grows mainly in the Mediterranean region and is used as a food flavoring, meat preserver, and for its floral aroma in fragrances.

Dried and fresh rosemary are used in culinary products and to make a refreshing rosemary tea.

What Is Rosemary Oil (Rosemary Essential Oil)?

Rosemary essential oil is made by a steam distillation process to extract the volatile oils from the leaves that contain all the health benefits.

Researchers say that the main components of rosemary essential oil are 1,8-cineole, camphor, rosmarinic acid, and alpha-terpineol. These compounds have antioxidant, antibacterial, and antitumor properties. Researchers point out that the health benefits of rosemary oil are due to a synergistic effect of all its medicinal compounds. (1)

Rosemary essential oil is a very aromatic herb, and people describe rosemary scent as piney and woody scent. Some people say that rosemary oil has a slight citrusy aroma.

In general, you should use 4-5 drops of rosemary essential oil for every tablespoon of carrier oil, or 10-12 drops for each 1 oz (30 ml) of carrier oil.

What Is Rosemary Oil Good For? (Rosemary Essential Oil Uses)

The therapeutic compounds in rosemary make rosemary essential oil a popular oil in aromatherapy.

Scientific research into the healing properties of rosemary oil has confirmed many of its traditional uses. The journal Future Science OA reports that rosemary essential oil is good for treating many of the following health conditions: (2)...


Pinterest Bans GreenMedInfo for Posting Natural Health & Vaccine Safety Info "IndyWatch Feed Health"

Pinterest, one of social media's largest players, is banning websites like GreenMedInfo which promote natural healing methods and provide access to peer-reviewed research questioning vaccine safety. 

On Dec. 13th, 2018 Pinterest removed, one of the worlds most trafficked and widely referenced natural health research sites, from its platform, stating: your linked website violated our misinformation policy. This policy includes things like promotion of false cures for terminal or chronic illnesses, and anti-vaccination advice.

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Argentina Creates Mandatory Vaccination Law For Passport, ID, Drivers License, School & More "IndyWatch Feed Health"


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In order to renew the DNI, passport and registration, the complete vaccination card must be presented.

The Senate approved on Wednesday a law that establishes the obligatory nature and free of vaccination against preventable diseases for all the inhabitants of the country, and stipulates that the complete vaccination card will be required at the time of processing the DNI, passport and driving record , among others.

The project was promoted by the Tucuman deputy Pablo Yedlin (Front Justicialista by Tucumn), and will replace the law 22,909, which is in force since 1983. So far, the mandatory vaccination applies only to children and the new project will be made extensive also to adults. The gratuity of the vaccines, in as much, happened in fact, but from now on it will be protected by law.

According to the text itself, it will be the Executive, through the Ministry of Health of the Nation, which must regulate in a term of 120 days the fine print of the norm for its specific application.

Its a law of much consensus, not only was it unanimous in both houses, but it had the support of all the scientific societies, and it puts Argentina at the height of its vaccination schedule, which is very generous, Yedlin said. dialogue with LA NACION.

Requirement for the DNI

The legislator also explained one of the points of the project that generated more controversy. Until now, proof of vaccination was a requirement to enroll in schools. But Article 9 of the new law states that the certification of compliance with the National Vaccination Calendar must be required also at the time of processing the ID, passport or drivers license.

It will not interrupt the processing of any document, said Yedlin and explained that in case of not presenting the full schedule of vaccinations, the person will be notified as well as the local health authority, to get in contact and offer the necessary vaccines.

They are control points, the Tucuman insisted. Its not that you will not be able to sign up for the fac...


Argentina Creates Mandatory Vaccination Law For Passport, ID, Drivers License, School & More "IndyWatch Feed Health"

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Sunday, 16 December


Infanrix Hexa 65 Toxins Found. All Risk. No Benefit. "IndyWatch Feed Health"

by Dr. Sherri Tenpenny, DO, AOBNMM, ABIHM Ive been saying for YEARS that we need to raise $50k to have every vaccine tested to see what is REALLY coming through that needle. This clearly came...

The post Infanrix Hexa 65 Toxins Found. All Risk. No Benefit. appeared first on Vaxxter.


Proven Health Benefits of Red Clover & How to Make Red Clover Tea "IndyWatch Feed Health"

Red clover comes as an herbal tea or supplement that can help manage many symptoms of the menopause. However the benefits of taking red clover supplements extend to more than just relieving hot flashes, fatigue, mood swings, and other menopausal symptoms. Red clover extracts can help strengthen bones, soothe coughing, and keep your skin looking healthy.

Taking red clover is good for both women and men. Scientific research on the benefits of red clover has found that red clover flower extracts can help to prevent hair loss in men. Red clover tea may benefit men because isoflavones in the extract also promote good prostate health.

In this article, you will find out about the many scientifically-proven benefits of taking red clover. You will also learn why taking red clover supplements is good if you are going through the menopause.

What Is Red Clover?

Red clover (Trifolium pratense) is a flowering plant that grows in Europe, parts of Africa, and Western Asia. Many of the health benefits of red clover are found in the blossoms of red clover.

Researchers from the National Center for Complementary and Integrative Health report that red clover blossoms contain isoflavones. These substances are phytoestrogens and they have a similar effect to the hormone estrogen. (1)

Studies into isoflavones extracted from red clover flowers have found that they can help relieve many menopausal symptoms. (2)

Red clover extracts are found in the form of supplements, pills, or capsules. You can also buy dried red clover flower if you want to make your own red clover tea at home.

What Is Red Clover Tea?

Red clover tea is a caffeine-free herbal infusion made by putting fresh or dried red clover flowers in a cup of hot water. Red clover tea has a mild fruity taste to it.

Drinking red clover tea can be especially useful if you have a cold or a persistent cough. Most women consume red clover tea to help alleviate many symptoms connected with the menopause.

At the end of the article you will find a recipe for making your own red clover tea.

Red Clover Nutrition

Red clover contains a number of beneficial compounds such as isoflavones and flavonoids.

Research into the nutritional value of red clover has revealed that it contains the phenolic compounds clovamide, flavanols, and quercetin. (3)

These compounds act as antioxidants in the body and are also known to have an anti-inflammato...

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Thursday, 13 December


FDA Warns About Dangers Of Epidural Steroid Injections For Back Pain "IndyWatch Feed Health"

There are few things quite as debilitating as excruciating back pain. It seems to overtake your entire life, leaving you miserable and unable to accomplish ordinary tasks since every waking moment is spent penetrated by the pulsating pain in your back. Often as a last resort, people suffering from severe back pain will turn to... View Article

The post FDA Warns About Dangers Of Epidural Steroid Injections For Back Pain appeared first on Healthy Holistic Living.

Wednesday, 12 December


Women Who Smoke Weed Have Higher IQs Than Those Who Dont "IndyWatch Feed Health"

What do you think about cannabis? Yea or nay? It is a controversial topic, isnt it? There is more and more research on its benefits. More and more states decriminalizing or legalizing it for medical, and even recreational purposes. Yet, many are still on the opposing side, believing that cannabis is for dopes only. (1)... View Article

The post Women Who Smoke Weed Have Higher IQs Than Those Who Dont appeared first on Healthy Holistic Living.

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