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Wednesday, 23 August

21:32

Iatrogenesis and Big Pharmas Lucrative Overvaccination Agendas "IndyWatch Feed Health"

By Gary G. Kohls, MD, guest to Natural Blaze

Ignaz Semmelweis, Galileo Galilei, Andrew Wakefield and the Semmelweis Reflex:

Iatrogenesis and Big Pharmas Lucrative Overvaccination Agendas

It is dangerous to be right in matters on which the established authorities are wrong.  Voltaire

If you offend the powers that be; if you offend the public health establishments; if you offend the pharmaceutical industry and threaten their bottom line (as we did by calling into question the safety of MMR [and later all the other vaccines that contain brain-toxic, mitochondrial-toxic and blood-brain barrier-toxic ingredients like aluminum and mercury ed note]) there is no price that you will not pay. You will be destroyed in order to protect their bottom line. Dr Andrew Wakefield

Anything that implies that immunizations are not the greatest medical advance in the history of public health is ignored or ridiculed. Can you imagine the economic and political import of discovering that immunizations are killing (or maiming) thousands of babies? Dr William C. Douglass, MD (Honored twice as Americas Doctor of the Year)

I was told by a network executive that during non-election years up to 70% of his news divisions revenues are from pharmaceutical corporations advertising. That executive told me that if one of his t...

21:06

BIOSCAN & BIOTONOMETER TO BE AHEAD OF TIME "IndyWatch Feed Health"

Worldwide Unique, Affordable, Modern Bioenergy Diagnostic What does modern therapy have to provide to practitioners, patients and private users? Customized therapy options Fast, accurate therapy results No need for other tools or devices Cost-effectiveness to save your money Easytooperate & understand Perfect for multiple applications (health, nutrition, supplementation, medication, fitness, etc.) We introduce BIOSCAN SWA

20:47

Peter Doshi flu vaccine study misused by anti-vaxxers "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Anti-vaccine activists constantly look for any science that seems to support their beliefs about the safety and effectiveness of vaccines. Lately, they have gravitated to the writings of Peter Doshi, who has made a career talking about vaccines. Although Doshi lacks the credentials in any area of science related to vaccines immunology, microbiology, virology,

Skeptical Raptor

20:36

Africans Do Not Want to be Used as Guinea Pigs for Untested American GMO Technology "IndyWatch Feed Health"

African_Farmer_watering_maize_1200x600

Africans must not be used as guinea pigs for untested high-risk new GM technology

by GMWatch.org

The Alliance for Food Sovereignty in Africa has called for an immediate ban on the importation into South Africa of Monsantos high-risk second-generation gene-silencing GM maize destined for human consumption.

In an open letter to African biosafety regulators, AFSA rejects and condemns US corporation Monsantos plan to exploit millions of Africans as unwitting human guinea pigs for their latest genetic engineering experiment. AFSA also condemns the IITA (International Institute of Tropical Agriculture) field trial application in Nigeria using this same risky technology to produce GM cassava for the agro-fuels industry.

These GM applications target staple foods of maize and cassava, eaten by many millions of Africans every day. AFSAs open letter states:

Scientists have reported that the untested gene-silencing effect is able to cross over into mammals and humans, and affect their genetic makeup with unknown potential negative consequences, and have called for long-term animal testing and stronger regulation before this goes ahead.

AFSA demands that while these risks remain, the introduction of this untested RNAi technology be unequivocally banned by all member states of the African Union. Regulators in South Africa and Nigeria are urged to reject the importation of this GM maize, and the field-testing of GM cassava. These grave threats to the health and well being of African peoples must be recognized, understood and resisted.

AFSA campaigns for food sovereignty the right of peoples to healthy and culturally appropriate food produced through ecologically sound and sustainable methods, and their right to dene their own food and agriculture systems. It urges African policymakers to reject genetic engineering and support the transition to agroecology as the sustainable future of farming in...

20:12

Girl Commits Suicide After Gardasil Vaccine Destroys Her Life "IndyWatch Feed Health"

maddie-gardasil-death2

Maddie died on June 24, 2017

Health Impact News

The VAXXED team recently interviewed a mother who tells about how her daughter took her own life after suffering from the Gardasil vaccine for several years.

A doctor in their church recommended the HPV vaccine to them. After receiving the second Gardasil vaccine at the age of 15, she became very lethargic and could hardly get out of bed, suffering from horrible headaches. They had to black out the light in her room because of the pain it caused, and she did not leave her bed for days.

Prior to the vaccine, she was healthy and active, and rarely missed a day of school.

The family had to hire a teacher to teach her sophomore year of high school since she could not leave her home.

After starting a very strict diet that an alternative health practitioner recommended, the family had some hope that she could recover.

But she battled depression, and it was learned from her journals after her death that she had a constant buzzing sound in her head. She had tried every anti-depressant drug on the market without success.

Listen to the whole tragic interview below.

Comment on this article at VaccineImpact.com.

gardasil_collage-3

Young women whose lives were destroyed by the HPV vaccine.

California Nurse Gives Gardasil Vaccine to Own Daughter who Develops Leukemia and Dies

...

20:08

parthenolide can be developed as a drug used in combination therapy against melanoma. "IndyWatch Feed Health"

PMID:  Oncotarget. 2016 Feb 23 ;7(8):9026-40. PMID: 26824319 Abstract Title:  Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-M(high) melanoma cell populations. Abstract:  The activity of the M isoform of microphthalmia-associated transcription factor (MITF-M) has been attributed to regulation of differentiation, proliferation, survival and senescence of melanoma cells. MITF expression was shown to be antagonized by the activation of transcription factor NF-B. Parthenolide, an inhibitor of NF-B, has not been yet reported to affect MITF-M expression. Our results obtained in patient-derived melanoma cell populations indicate that parthenolide efficiently decreases the MITF-M level. This is neither dependent on p65/NF-B signaling nor RAF/MEK/ERK pathway activity as inhibition of MEK by GSK1120212 (trametinib) and induction of ERK1/2 activity by parthenolide itself do not interfere with parthenolide-triggered depletion of MITF-M in both wild-type BRAF and BRAF(V600E) melanoma populations. Parthenolide activity is not prevented by inhibitors ofcaspases, proteasomal and lysosomal pathways. As parthenolide reduces MITF-M transcript level and HDAC1 protein level, parthenolide-activated depletion of MITF-M protein may be considered as a result of transcriptional regulation, however, the influence of parthenolide on other elements of a dynamiccontrol over MITF-M cannot be ruled out. Parthenolide induces diverse effects in melanoma cells, from death to senescence. The mode of the response to parthenolide is bound to the molecular characteristics of melanoma cells, particularly to the basal MITF-M expression level but other cell-autonomous differences such as NF-B activity and MCL-1 level might also contribute. Our data suggest that parthenolide can be developed as a drug used in combination therapy against melanoma when simultaneous inhibition of MITF-M, NF-B and HDAC1 is needed.

read more

20:01

New: CIA Agent Whistleblower Risks All To Expose The Shadow Government "IndyWatch Feed Health"

GeoengineeringWatch.org 6675Dane Wigington GeoengineeringWatch.org Kevin Shipp was a decorated CIA officer who refused to look the other way in regard to government criminality and cover-up. At a very important public awareness event, recently held in Northern California by GeoengineerWatch.org, Mr. Shipp presented a shocking and compelling presentation on numerous, horrific and ongoing government crimes. The total persecution

19:55

The Criminal Intent of Compulsory Vaccination "IndyWatch Feed Health"

by Dr. Stefanie Hillinger, Independent Research Center, The Dayeng Foundation Are compulsory vaccinations in Italy and France mass murder by the System? No argument can justify this. Putting something into the body of another human being under...

The post The Criminal Intent of Compulsory Vaccination appeared first on Vaxxter.

19:53

Girl Commits Suicide After Gardasil Vaccine Destroys Her Life "IndyWatch Feed Health"

maddie-gardasil-death2

Maddie died on June 24, 2017

Health Impact News

The VAXXED team recently interviewed a mother who tells about how her daughter took her own life after suffering from the Gardasil vaccine for several years.

A doctor in their church recommended the HPV vaccine to them. After receiving the second Gardasil vaccine at the age of 15, she became very lethargic and could hardly get out of bed, suffering from horrible headaches. They had to black out the light in her room because of the pain it caused, and she did not leave her bed for days.

Prior to the vaccine, she was healthy and active, and rarely missed a day of school.

The family had to hire a teacher to teach her sophomore year of high school since she could not leave her home.

After starting a very strict diet that an alternative health practitioner recommended, the family had some hope that she could recover.

But she battled depression, and it was learned from her journals after her death that she had a constant buzzing sound in her head. She had tried every anti-depressant drug on the market without success.

Listen to the whole tragic interview below.

gardasil_collage-3

Young women whose lives were destroyed by the HPV vaccine.

California Nurse Gives Gardasil Vaccine to Own Daughter who Develops Leukemia and Dies

Infant Accidentall...

19:21

Skin Problems and Their Treatments "IndyWatch Feed Health"

SKIN PROBLEMS AND TREATMENTS Treating medical problems in a remote homestead or after a disaster wont always be about gunshot wounds and broken bones.  Sometimes, little things can make people miserable and affect their ability to contribute to group efforts. Skin inflammation, called dermatitis, is one of the issues that a caregiver cant ignore if the group is going to function at 100% efficiency. This condition has various causes and varies in appearance from case to case, although most present

[... Continue Reading]

18:32

Targeting thioredoxin reductase by parthenolide contributes to inducing apoptosis of HeLa cells. "IndyWatch Feed Health"

PMID:  J Biol Chem. 2016 May 6 ;291(19):10021-31. Epub 2016 Mar 21. PMID: 27002142 Abstract Title:  Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. Abstract:  Parthenolide (PTL), a major active sesquiterpene lactone from the herbal plant Tanacetum parthenium, has been applied in traditional Chinese medicine for centuries. Although PTL demonstrates potent anticancer efficacy in numerous types of malignant cells, the cellular targets of PTL have not been well defined. We reported here that PTL interacts with both cytosolic thioredoxin reductase (TrxR1) and mitochondrial thioredoxin reductase (TrxR2), two ubiquitous selenocysteine-containing antioxidant enzymes, to elicit reactive oxygen species-mediated apoptosis in HeLa cells. PTL selectively targets the selenocysteine residue in TrxR1 to inhibit the enzyme function, and further shifts the enzyme to an NADPH oxidase to generate superoxide anions, leading to reactive oxygen species accumulation and oxidized thioredoxin. Under the conditions of inhibition of TrxRs in cells, PTL does not cause significant alteration of cellular thiol homeostasis, supporting selective target of TrxRs by PTL. Importantly, overexpression of functional TrxR1 or Trx1 confers protection, whereas knockdown of the enzymes sensitizes cells to PTL treatment. Targeting TrxRs by PTL thus discloses an unprecedented mechanism underlying the biological activity of PTL, and provides deep insights to understand the action of PTL in treatment of cancer.

read more

18:30

Vaccine Mandates: The Spite House Well All Have to Live In "IndyWatch Feed Health"

August 23, 2017 Today were doing something a little different. Jill Boman, a Facebook friend of mine, posted a comment linking spite houses and vaccine mandates, and it was so good I asked her to write us a blog on Continue reading

The post Vaccine Mandates: The Spite House Well All Have to Live In appeared first on The Thinking Moms' Revolution.

18:14

Parthenolide exerts cytotoxic effects on breast cancer stem-like cells. "IndyWatch Feed Health"

PMID:  Cell Death Dis. 2016 Apr 14 ;7:e2194. Epub 2016 Apr 14. PMID: 27077810 Abstract Title:  Parthenolide and DMAPT exert cytotoxic effects on breast cancer stem-like cells by inducing oxidative stress, mitochondrial dysfunction and necrosis. Abstract:  Triple-negative breast cancers (TNBCs) are aggressive forms of breast carcinoma associated with a high rate of recidivism. In this paper, we report the production of mammospheres from three lines of TNBC cells and demonstrate that both parthenolide (PN) and its soluble analog dimethylaminoparthenolide (DMAPT) suppressed this production and induced cytotoxic effects in breast cancer stem-like cells, derived from dissociation of mammospheres. In particular, the drugs exerted a remarkable inhibitory effect on viability of stem-like cells. Such an effect was suppressed by N-acetylcysteine, suggesting a role of reactive oxygen species (ROS) generation in the cytotoxic effect. Instead z-VAD, a general inhibitor of caspase activity, was ineffective. Analysis of ROS generation, performed using fluorescent probes, showed that both the drugs stimulated in the first hours of treatment a very high production of hydrogen peroxide. This event was, at least in part, a consequence of activation of NADPH oxidases (NOXs), as it was reduced by apocynin and diphenylene iodinium, two inhibitors of NOXs. Moreover, both the drugs caused downregulation of Nrf2 (nuclear factor erythroid 2-related factor 2), which is a critical regulator of the intracellular antioxidant response. Prolonging the treatment with PN or DMAPT we observed between 12 and 24h that the levels of both superoxide anion and hROS increased in concomitance with the downregulation of manganese superoxide dismutase and catalase. In addition, during this phase dissipation of mitochondrial membrane potential occurred together with necrosis of stem-like cells. Finally, our results suggested that the effect on ROS generation found in the first hours of treatment was, in part, responsible for the cytotoxic events observed in the successive phase. In conclusion, PN and DMAPT markedly inhibited viability of stem-like cells derived from three lines of TNBCs by inducing ROS generation, mitochondrial dysfunction and cell necrosis.

read more

17:58

First Of Its Kind Study Shows Undeniable Evidence Cannabis Can Cure Opioid Addiction "IndyWatch Feed Health"

By Justin Gardner

As the opioid epidemic rages on, those professing to seek solutions are willfully ignoring one of the most promising treatments medical cannabis. When the Comprehensive Addiction & Recovery Act (CARA) was being debated in 2016, amendments to study medical cannabis were stripped out.

This happened despite studies showing that medical cannabis eases neuropathic pain, and the governments own National Institutes of Health stating, Medical marijuana products may have a role in reducing the use of opioids needed to control pain.

There were also studies showing that deaths from opioids plummet in states with legal cannabis, and that 80 percent of cannabis users give up prescription pills. A Feb. 2017 study confirmed that opioid dependence and overdoses dropped significantly in medical cannabis states.

In January 2017, the...

17:47

Parthenolide induces apoptosis and autophagy-mediated growth inhibition in HeLa cells. "IndyWatch Feed Health"

PMID:  Biotechnol Lett. 2016 Aug ;38(8):1251-60. Epub 2016 Apr 21. PMID: 27099069 Abstract Title:  Parthenolide induces apoptosis and autophagy through the suppression of PI3K/Akt signaling pathway in cervical cancer. Abstract:  OBJECTIVE: To investigate the effect of parthenolide on apoptosis and autophagy and to study the role of the PI3K/Akt signaling pathway in cervical cancer.RESULTS: Parthenolide inhibits HeLa cell viability in a dose dependent-manner and was confirmed by MTT assay. Parthenolide (6 M) induces mitochondrial-mediated apoptosis and autophagy by activation of caspase-3, upregulation of Bax, Beclin-1, ATG5, ATG3 and down-regulation of Bcl-2 and mTOR. Parthenolide also inhibits PI3K and Akt expression through activation of PTEN expression. Moreover, parthenolide induces generation of reactive oxygen species that leads to the loss of mitochondrial membrane potential.CONCLUSION: Parthenolide induces apoptosis and autophagy-mediated growth inhibition in HeLa cells by suppressing the PI3K/Akt signaling pathway and mitochondrial membrane depolarization and ROS generation. Parthenolide may be a potential therapeutic agent for the treatment of cervical cancer.

read more

17:42

9 Natural Arthritis Remedies "IndyWatch Feed Health"

By Adonia Dennis, Natural Blaze

Arthritis is a disease that can cause severely painful symptoms in joints throughout the entire body. According to the Arthritis Foundation, over 50 million American adults have been diagnosed with some form of arthritis, which accounts for more than 20% of all people of the age of 18 in the United States. In addition to these statistics, at least 300,000 children in the country have some form of arthritis or a rheumatic disease.

This particular disease is the primary cause of disability in the United States and many other countries in the world. The Centers for Disease Control and Prevention reports that the most common types of arthritis diagnosed in the United States include osteoarthritis and rheumatoid arthritis, with gout, fibromyalgia, and lupus also being fairly common.

While the majority of arthritis types are not curable diseases, the symptoms they cause can be controlled, and the progression of the diseases can be slowed down with appropriate treatment options.

...

17:39

TODAY: last day to save on conference hotel room "IndyWatch Feed Health"

Today, August 23rd, is the last day to book your hotel room for the the 6th Citizens Conference on Fluoride at a significantly discounted rate!

CLICK HERE TO RESERVE YOUR ROOM

The conference will take place at:

Hyatt Regency Hotel, Crystal City, Virginia
on September 1618, 2017

The hotel is terrific and each room has WiFi.  Its located in a safe area with several restaurants close-by.  Its also close to the Washington DCA airport where there is a free hotel shuttle bus, and its just a few quick metro (subway) stops from Union Station in Washington, D.C. see more on our conference Overview page.

Important Links

17:36

Parthenolide ameliorates diabetes-induced behavioural deficit, neurotransmitter imbalance and neuroinflammation in type 2 diabetes rat model. "IndyWatch Feed Health"

PMID:  Neuromolecular Med. 2017 Mar ;19(1):101-112. Epub 2016 Aug 23. PMID: 27553015 Abstract Title:  Parthenolide, an NF-B Inhibitor Ameliorates Diabetes-Induced Behavioural Deficit, Neurotransmitter Imbalance and Neuroinflammation in Type 2 Diabetes Rat Model. Abstract:  Diabetes is associated with behavioural and neurochemical alterations. In this manuscript, we are reporting the beneficial effects of parthenolide, an NF-B inhibitor on behavioural and neurochemical deficits in type 2 diabetic rat model. Diabetes was induced by high-fat diet followed by low dose of streptozotocin (35 mg/kg). Elevated plus maze, open-field, MWM and passive avoidance test paradigm were used to assess behavioural and cognitive deficits. Three-week treatment of parthenolide (0.25 and 0.50 mg/kg; i.p.) attenuated diabetes-induced alteration in cognitive function in Morris water maze and passive avoidance test. Anxiety-like behaviour was also reduced by parthenolide treatment. Moreover, TNF- and IL-6 levels were significantly decreased in cortex and hippocampus of parthenolide-treated rats. Three-week parthenolide treatment also toned down the alteration of GABA and glutamate homoeostasis. Results of this study corroborate the involvement of neuroinflammation in the development of behavioural and neurochemical deficits indiabetic animals and point towards the therapeutic potential of parthenolide in diabetes-induced alteration of learning, memory and anxiety behaviour.

read more

17:25

Florida Teen Suffers Debilitating Narcolepsy "IndyWatch Feed Health"

Ruth Hamper: If he goes down, we need to get to him right away to keep him safe. A Florida teenager has been diagnosed with a rare disease that causes him to fall asleep for...

The post Florida Teen Suffers Debilitating Narcolepsy appeared first on Vaxxter.

17:10

Sign the Statement to Defend Kratom "IndyWatch Feed Health"

By Dave Herman
Chairman, American Kratom Association

On August 31, 2016, the Drug Enforcement Administration (DEA) rocked the kratom world with their now infamous Notice of Intent for Emergency Scheduling of kratom as a Schedule I controlled substance.

That was truly the day that the federal government declared war on kratom and war on every one of us who believe that consumers should have the freedom to make their own decisions about how to manage their health and well-being.

But the truth is, the DEA and the FDA picked a fight with people who were unwilling to be trampled upon by the unfair and arbitrary criminalization of kratom and of the basic freedoms we have every right to enjoy.

The attempt to schedule kratom ignited a grassroots movement that continues to this very day, and I am pleased to report that we are growing stronger and stronger in our continued fight against the demonization of kratom by these federal bureaucrats.

On August 31, 2017, I intend to deliver a statement to the Presidential Commission on Combating Drug Addiction and the Opioid Crisis asking the government to recognize the numerous studies that show kratom can be used as an alternative pain management option, but kratom can also be a potentially effective Reverse-Gateway out of opioid addiction.

I am hoping that you will sign up to be an official co-signer on the American Kratom Association Statement to the Opioid Commission.

Please click on the link below and review the Statement to the Commission.  If you agree with the Statement, and I hope you will, then I need you to add your name as an official co-signer of the statement.

...

17:00

Former MD Anderson researcher objects to retraction of his paper "IndyWatch Feed Health"

A cell biology journal has retracted a 2016 paper after an investigation revealed that the corresponding author failed to include two co-authors and acknowledge the funding source. According to the retraction notice, the Journal of Cellular Physiology retracted the paper after the University of Texas, MD Anderson Cancer Center found that last author Jin Wang []

The post Former MD Anderson researcher objects to retraction of his paper appeared first on Retraction Watch.

16:15

Some Thoughts About Conferences "IndyWatch Feed Health"

Editors note: for personal and family reasons the author has chosen to publish under a pen name. 

It might sound strange, as I still get told a lot how young I seem to be, but Im fed up with attending conferences. At each of them we talk and analyze psychiatry as if we have to justify to ourselves that were standing on the right side, or as if were waiting for someone to give us the right to do what we do. We repeat again and again whats wrong with psychiatry, how we need different forms of support, that a social change is needed, etc. From conference to conference I keep asking myself, why all this?

Without judging the motivation of people presenting and speaking at conferences and without forgetting that ex-users of psychiatry are still struggling to be heard and conferences are there to give voice to those with lived experience Id like to ask the question: can we achieve more with these conferences than generating knowledge and touching peoples hearts?

Why is it important to ask such a question? It is important because we are judging a miserable situation in society. We should therefore ask ourselves if our kind of disputation, which is mainly critical and analytical, fits with the judged grievance. In other words: are we preparing the ground for change or are we marking time?

We all know whats going wrong in psychiatry and what should be changed. Weve known for decades. Thats the reason I dont think well make much difference with further analyses of this kind. What we need is to work out strategies for how to use our critique to change and abolish psychiatry. We need to analyze where the cracks in psychiatry are, and take action with our critique at exactly those points to knock over the monopoly on truth that psychiatry has had. We need to sit with each other and discuss how we can build up places to support each other and be who we are, no matter what anyone else is saying about who and what we are. Reaching out for more people to join our movement is quite important, but it feels secondary to me. It feels more urgent to ask: where and when will we start to attack?

This step away from defense to attack takes a lot of courage and strength. We have to pit oursel...

16:07

Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. "IndyWatch Feed Health"

PMID:  Exp Oncol. 2017 03 ;39(1):30-35. PMID: 28361855 Abstract Title:  Parthenolide reduces gene transcription of prosurvival mediators in U937 cells. Abstract:  : In acute myeloid leukemia (AML) the functional abnormalities of osteopontin (OPN), NF-kB, PI3K/AKT/mTOR/PTEN pathway or-catenin have been considered.AIM: To analyze the response of U937 cells to parthenolide (PTL) through the involvement of expression of OPN protein, RelB, AKT1, mTOR, PTEN and-catenin genes.MATERIALS AND METHODS: The U937 cells were treated with PTL at concentrations of 4M (IC25) or 6 M (IC50) and with OPN siRNA for MTT assay and colony forming assay. Western blot analysis using antibodies against OPN was performed with lysates of PTL-treated cells. Quantitative real-time polymerase chain reaction was performed using primers for OPN siRNA, RelB, AKT1, mTOR, PTENand -catenin.RESULTS: PTL reduces OPN protein level and down-regulates RelB mRNA in U937 cell line. Suppression of OPN with siRNA increases the cytotoxic effects of PTL. Also, mRNA expression of AKT1, mTOR, PTEN, and-catenin decreases with PTL or OPN siRNA.CONCLUSION: Sensitivity of U937 cells to PTL can be associated with the reduction in expression of prosurvival mediators.

read more

15:55

Parthenolide may be a promising component for bone regeneration in periodontitis treatment. "IndyWatch Feed Health"

PMID:  J Interferon Cytokine Res. 2017 Aug 22. Epub 2017 Aug 22. PMID: 28829282 Abstract Title:  Parthenolide Promotes Differentiation of Osteoblasts Through the Wnt/-Catenin Signaling Pathway in Inflammatory Environments. Abstract:  Periodontitis is a progressive inflammatory disease initiated by bacterial biofilm adhering to the tooth surface. If left untreated, periodontitis may lead to tooth loss and destruction of the alveolar bone. Regaining the lost alveolar bone is a clinical challenge because of the limited differentiation ability of osteoblasts in inflammatory environments. We have previously shown the anti-inflammatory and antiosteoclastogenic activities of parthenolide (PTL) in human periodontal ligament-derived cells by inhibiting nuclear factor kappa B (NF-B) signaling, indicating its potential for periodontitis treatment. In this study, we further examined whether PTL could stimulate differentiation of osteoblasts from human alveolar bone in inflammatory conditions and investigated the involvement of the Wnt/-catenin signaling pathway during thisprocess. The results showed that PTL significantly stimulated alkaline phosphatase activity, mineralization nodule formation, and osteogenesis-related gene/protein expression of osteoblasts under the stimulation of tumor necrosis factor- (TNF-). In addition, PTL inhibited the NF-B/p50 pathwayand resisted the inhibition of Wnt/-catenin signaling induced by TNF-. Our results indicate that the stimulatory effect of PTL on the differentiation of osteoblasts in inflammatory environments may involve the activation of the Wnt/-catenin signaling pathway, and PTL may be a promising component for bone regeneration in periodontitis treatment.

read more

15:19

Vaccine Disasters Governments Want You To Forget "IndyWatch Feed Health"

By Jon Rappoport

Parents who question vaccines are crazy? Really? Parents who claim to discover vaccine-dangers are crazy? Really?

Official history is a curious thing. Whole sections of fact disappear from the record.

When I was researching my first book, AIDS INC., in 1987-88, I explored various forms of immune-system suppression, in order to show that HIV was not the real story.

I looked into vaccines, for example. Here is an excerpt from AIDS INC. Keep in mind that my research, at the time, ended in 1988. This excerpt reports on vaccines disasters and statements about vaccines made by several authors.

It is forgotten history:

  • Based on the only U.S. findings on adverse DPT [diphtheria-pertussis-tetanus vaccine] reactions, an FDA-financed study at the University of California, Los Angeles, one out of every 350 children will have a convulsion; one in 180 children will experience high-pitched screaming [can indicate brain damage]; and one in 66 will have a fever of 105 degrees or more. (Jennifer Hyman, Democrat and Chronicle, Rochester, New York, special supplement on DPT, dated April, 1987.)
  • A study undertaken in 1979 at the University of California, Los Angeles, under the sponsorship of the Food and Drug Administration, and which has been confirmed by other studies, indicates that in the U.S.A. approximately 1,000 infants die annually as a direct result of DPT vaccinations, and these are classified as SIDS (Sudden Infant Death Syndrome) deaths. These represent about 10 to 15% of the total number of SIDS deaths occurring annually in the U.S.A. (between 8,000 and 10,000 depending on which statistics are used). (Leon Chaitow, Vaccination and Immunization, CW Daniel Company Limited, Saffron Walden, Essex, England, 1987.)
  • Assistant Secretary of Health Edward Brandt, Jr., MD, testifying before the U.S. Senate Committee on Labor and Human Resources, rounded figures off to 9,000 cases of convulsions, 9,000 cases of collapse, and 17,000 cases of high-pitched screaming for a total of 35,000 acute neurological reactions occurring within forty-eight hours of a DPT shot among Americas children every year. (DPT: A Shot in the Dark, by Harris L. Coulter and Barbara Loe Fischer, Harcourt Brace Jovanovich.)
  • Barker and Pichichero, in a prospective study of 1232 children in Denver, Colorado, found after DTP that only 7% of those vaccinated were free from untoward reactions, which included pyrexia [fever] (53%), acute behavioral changes (82%), prolonged screaming (13%), and listlessness, anorexia and vomiting. 71% of those receiving second injections of DTP experienced two or more of the reactions monitored. (Lancet, May 28, 1983, p. 1217)
  • ...

15:18

AQMD: Not enough data to prove safety of deadly toxic chemical used at Torrance refinery "IndyWatch Feed Health"

Southern Californias air quality watchdog has become the latest regulatory agency to cast doubt on the safety of a potentially deadly chemical used at the Torrance refinery, concluding there is not enough evidence to dismiss concerns that a toxic cloud could form and kill or injure tens of thousands.

South Coast Air Quality Management District staff members came to what they described as an initial conclusion while reviewing data provided by refinery owner PBF Energy via its subsidiary, the Torrance Refining Co.

The agency is exploring whether to create a rule that would phase out the use of hydrofluoric acid, especially in the massive quantities used in Torrance.

A modified form of the acid is used in Torrance and at Valeros Wilmington refinery, the only two in the state that use hydrofluoric acid.

The MHF is supposed to inhibit the formation of the cloud; critics have questioned whether that would actually occur.

Meanwhile, the AQMD also questioned whether existing safety measures are sufficient to prevent a catastrophic HF release of the sort federal officials said almost occurred in February 2015, when a massive explosion ripped through the plant then owned by ExxonMobil.

Data Lacking

Staffs initial conclusion is that the testing/modeling information provided by Torrance Refining Company did not sufficiently demonstrate MHF would not flash atomize and form dense HF cloud, reads a report posted on the agencys website earlier this month.

Even existing mitigations do not guarantee adequate protection in (an) unplanned event such as a major accident or earthquake causing equipment failure, the report added.

A full report is scheduled to be presented today at the fifth meeting of a working group in Diamond Bar that is looking at the new rule.

The AQMD indicated that preliminary language on the new rule and a staff report would be prepared ahead of a September working group meeting.

This is the first time the AQMD has sided with such agencies as the federal Chemical Safety Board and Environmental Protection Agency that also have cast doubt on the safety of MHF and the effectiveness of safety systems meant to protect the community.

...

15:11

Albuquerque: Fluoride could be added to metros drinking water; final vote tonight "IndyWatch Feed Health"

Citizens will be able to weigh in on a proposed plan that would once again add more fluoride to drinking water in Albuquerque.

Members of the water authority board are expected to make a final vote on a plan to spend more than $200,000 for equipment and facilities to allow the city to resume fluoridation.

Now, the debate over adding fluoride to the metros water is heating up again. While officials say it would prevent tooth decay, there are some who believe fluoride is a toxic chemical.

Back in the 1970s, citizens approved the fluoridation of drinking water. In 2011, the Albuquerque Bernalillo County Water Utility Authority halted those operations as they waited for new federal fluoride level recommendations to eventually be released in 2015.

What is being voted on Wednesday night is a one-time cost of $260,000 coming from capital funds, which would pay for the construction of a new facility at the San Juan Chama Plant. Officials say it would cost $270,000 a year for operation and maintenance costs.

Officials also say it would add fluoride to the already existing levels of in the water, bringing it to .07 milligrams, the most beneficial level for residents.

Supporters of supplemental fluoridation are concerned about the dental health in our community, particularly in underserved populations who may not be able to get to a dentist regularly. They see this as a way of helping to improve the dental health for those populations, David Morris, Public Affairs Manager with the Water Authority said.

The proposed plan doesnt come without controversy. The Department of Health says theyve received opposition from people saying that fluoride causes health problems such as Alzheimers disease.

The final vote is expected to happen at Vincent E. Griego Council Chambers at 5 p.m.

It is open to public comment. If you are unable to attend, you can email comments to ABQFluoride2017@gmail.com.

*Original article online at http://krqe.com/2017/08/23/fluoride-could-be-added-to-metros-drinking-water-final-vote-tonight/

15:06

Port Angeles: Council Candidates Discuss Fluoridation Issue "IndyWatch Feed Health"

PORT ANGELES Two candidates vying for a seat on the Port Angeles City Council agreed Tuesday the city should eschew second-class status and encourage economic development and weighed in on an avigation easement for William R. Fairchild Memorial Airport.

Lindsey Schromen-Wawrin and Artur Wojnowski disagreed on how to answer a Nov. 7 advisory vote on fluoridated drinking water, annexation and other issues during a Port Angeles Business Association forum at Joshuas Restaurant.

Wawrin and Wojnowski are running in the November general election for Port Angeles City Council Position 3, a four-year nonpartisan position held by Mayor Patrick Downie. Downie is not running for re-election.

Schromen-Wawrin, a Port Angeles native and a lawyer, was a Democratic Party precinct committeeman and recent president of the Clallam County Bar Association.

Wojnowski, a Chicago native who was raised in a Polish household, is maintenance manager for the Dungeness Meadows Home Owners Association.

I dont believe that we should be fluoridating the water, Wojnowski said.

The City Council voted 4-3 last August to stop adding fluoride to the municipal water supply, ending a 10-year-old practice.

Downie, who voted in December 2015 to continue fluoridation, cast the deciding vote last summer.

I believe that we dont know how much [fluoride] we all need to intake, Wojnowski said.

And given the fact that none of us really know how much is required, personally I dont think we should just be blanketing it. But again, thats for everyone to decide on their own.

Schromen-Wawrin said he had a more nuanced view on fluoride, saying the chemical has been shown to improve oral health and that he uses fluoride in his daily dental regime.

Schromen-Wawrin said he would personally vote no on the advisory vote but listen to the will of the voters and act accordingly, provided he has assurances that the city would not put lead and arsenic in the water.

Weve been gridlocked for too long and we need to move on from this issue, Schromen-Wawrin said.

I think at this point this issue has been tossed to the will of the people, which is not necessarily the best way to decide public health matters.

So in that regard, I think Id vote with what the voters said, with my caveat that Im not going to be putting lead and arsenic in the water supply in a knowing and intentional way.

Wojnowski said he will oppose fluoridation regardless of the advisory vote.

People can voice their opinion vot...

14:24

New Name for a Nasty Game "IndyWatch Feed Health"

By Kim Rossi (formerly Stagliano, but that's another book altogether.) While the nation was descending into darkness, both partial and full on Monday, courtesy of the solar eclipse, I noticed a lot of Tweets and FB posts laughing about "FlatEarthers."...

14:00

Data had been manipulated, again: Swiss probe prompts two more retractions "IndyWatch Feed Health"

A biologist at the University of Basel is retracting two papers, citing data manipulation uncovered during an institutional investigation. That investigation has already led to the retraction of a paper in Science Translational Medicine by some of the same authors earlier this year. The two latest retractions, in the Journal of Biological Chemistry (JBC), share []

The post Data had been manipulated, again: Swiss probe prompts two more retractions appeared first on Retraction Watch.

13:50

The Promise of CRISPR "IndyWatch Feed Health"

CRISPR is the latest rock-star medical technology that promises to revolutionize medicine. Let's take a look at the hype and the reality.

12:02

App Allows You to Call Volunteers to Help the Homeless "IndyWatch Feed Health"

From Healthline: A new app, Concrn, allows users to request assistance from mental health volunteers for homeless people in need. The creators of the app hope to provide a community-based crisis response that can be used as an alternative to calling 911.

When police respond to community needs related to mental health, substance use, or people experiencing homelessness, it can result in further escalation, violence, or incarceration. Sometimes those interactions are fatal, the Concrn team told Healthline in a statement. When you have members of a community responding to their own crises using de-escalation skills and supporting the person into available services, youre really taking more of a transformative approach.'

Article

12:01

Third of Men With Poor Mental Health Blame Jobs, Says Mind "IndyWatch Feed Health"

From BBC: According to survey results from the UK mental health charity Mind, a third of men experiencing poor mental health attribute their suffering to workplace stress. Women, on the other hand, found their job and home life equally stressful.

Article

12:00

Can You Cure Autism? Ask Dr. Kartzinel At The Autism Education Summit In Dallas. "IndyWatch Feed Health"

Autism Education Summit Sponsored by Generation Rescue 9/29 - 10/1 Dallas, Texas GO GO. GO.

09:36

Hear Voices? Your Brain May Be Sharper Than The Rest "IndyWatch Feed Health"

Researchers in the United Kingdom say they've discovered that such individuals use unusual skills when their brains process sound and that such 'voice-hearers' may be able to detect disguised speech-like sounds more quickly and easily than folks who had never had a voice-hearing experience. It suggests their brains tend more readily to detect meaningful speech patterns in ambiguous sounds.

07:00

New Research Reveals Why Avoiding Tuna Is Still a Good Idea "IndyWatch Feed Health"

By Dr. Mercola

Fish has always been the best dietary source of the animal-based omega-3 fats EPA and DHA. While your body may be able to produce some of these fats, the process is relatively inefficient, so they are considered conditionally essential.1 This means to acquire sufficient amounts for optimal health, you need to consume the omega-3 fats EPA and DHA from your food.

Unfortunately, as the levels of pollution in the oceans have increased, so have the toxins you consume. If you arent choosy about where your fish is harvested, the pollutants in the fish may outweigh the benefits of the healthy fats. At the same time, many fish species have been overfished and dangerously depleted. Orange roughy is one example. A slow growing, deep water fish, they dont usually reproduce until age 20 and may live up to 149 years.2

In the 1980s the popularity of orange roughy exploded and led to driving it almost to extinction. In some areas, fishing for roughy has been restricted and scientists expect it to take many years for the population to recover, if it ever does. Farm-raised fish are also not the answer as they present problems for both the environment and the consumer.3

Raising fish in a confined area results in the same kind of waste pollution problems as land-based factory animal farms struggle with. Fish farms also reduce biodiversity, spread disease and sea lice, and contaminate water with pesticides. It is important to consider not only your health but also the impact on the environment when choosing seafood for your family.

Why Tuna Is Best Avoided

Historically, tuna has been a very popular fish, and among the most widely consumed. They are known for a distinctive flavor and versatility in the kitchen. There are at least 15 different species,4 but only five are commonly fished and eaten. Depending upon the species, the adults can weigh from 10 pounds up to 500 pounds. The largest is the Atlantic bluefin tuna that is migratory and can travel at great speeds o...

Is Chronic Fatigue Real? "IndyWatch Feed Health"

By Dr. Mercola

Chronic fatigue syndrome (CFS) is a debilitating condition that affects up to 2.5 million Americans,1 incurring up to $51 billion in annual medical costs.2 There are actually a number of different names used for this condition, including myalgic encephalopathy/myalgic encephalomyelitis (ME), post-viral fatigue syndrome (PVFS) and chronic fatigue immune dysfunction syndrome (CFIDS).3 The most common designation is ME/CFS.

Without an ability to pinpoint a cause, many physicians have credited the condition to psychological roots. Reports of the condition were first published in the literature in 1934.4 It has only been very recently that researchers have found physiological commonalities between groups of individuals that has separated their symptoms from other comparable conditions.

Diagnostic changes have been discovered in gut bacteria and in brain tissue of individuals suffering from symptoms of ME/CFS. Now, scientists have found biomarkers in blood that correlate with ME/CFS symptoms. This combination of information puts researchers one step closer to finding a causative agent, and potentially improving treatment options.

What Is Chronic Fatigue Syndrome?

Researchers have not found a reason for the symptoms of ME/CFS. A significant hurdle is the fact that symptoms can vary widely from one person to the next. However, the most common symptom is one of overwhelming exhaustion that gets worse with physical or mental activity, and does not get better with additional rest.5 Interestingly, you may not experience the full extent of the exhaustion until up to 48 hours after the activity.

Complications from the symptoms may also include depression, social isolation, increasing absences at work and lifestyle restrictions that are related to an inability to function at your activities of daily living.6

The condition affects people of all socioeconomic, ethnic and raci...

The Problem With Organic Hydroponics "IndyWatch Feed Health"

By Dr. Mercola

Hydroponically grown vegetables and berries are increasing in popularity. But is hydroponics a healthy, sustainable and organic way to grow food? Section 7 CFR 205.2051,2 of the U.S. Department of Agricultures (USDA) organic regulations require that your crop rotation plan maintains or improves soil organic matter. Since hydroponics does not involve the use of soil, it does not qualify for organic certification.

Despite such clear-cut distinctions in the law, the Organic Trade Association and the hydroponic lobby, led by the Coalition for Sustainable Organics, are pushing to rewrite organic rules to include hydroponics. Theyre also seeking to reform the National Organic Program (NOP), reduce the influence of the National Organic Standards Board (NOSB) and alter the composition of the NOSB to improve trade representation.

They got their way, and the American people got voluntary smart labels in lieu of GMO labeling. In return, Roberts has become a strong supporter of the Coalition.

Hostile Takeover by Corporate Organics

As noted by Dave Chapman of Long Wind Farm in an article discussing the Coalition for Sustainable Organics Congressional testimony in June:3

We are witnessing an attempted hostile takeover of the National Organic Program The very fact that Congress was listening to a fringe group like the Coalition for guidance on organics is a clear sign that the organic community is in deep trouble

Melody Meyer, a spokesperson for United Natural Foods and one of the leading hydro lobbyists, has described the hydro battle as a conflict between two parts of the organic community: The Trade and the Movement. This is not an accurate description because the Coalition for Sustainable [Organics] has...

06:59

They Just Swept it Under the Carpet: A 6-Week-Old Boy Was Accidentally Injected with Gardasil. What Happened Next Raises Plenty of Questions "IndyWatch Feed Health"

The Topperwien family shaved their heads to support their son Chace going through conventional cancer treatment. PHOTO: Stuff.co.nz

 

 

01:42

Pterostilbene suppresses human endometrial cancer cells in vitro by down-regulating miR-663b. "IndyWatch Feed Health"

PMID:  Acta Pharmacol Sin. 2017 May 29. Epub 2017 May 29. PMID: 28552912 Abstract Title:  Pterostilbene suppresses human endometrial cancer cells in vitro by down-regulating miR-663b. Abstract:  Resveratrol has long been known as an antioxidant and a chemopreventive agent. Similar to resveratrol, pterostilbene (PT) is also a phenolic compound extracted from the Vitis species. However, there are few studies on the antitumor effect of PT. Thus, we investigated the effects of PT on the endometrial cancer (EC) cells in vitro and the related molecular mechanisms. Treatment of EC cell lines HTB-111 and Ishikawa with PT (25-100mol/L) dose-dependently suppressed the cell viability and induced apoptosis. Using miR microarrays, we examined the miR expression profile in Ishikawa cells with or without PT, and revealed that miR-663b was the most decreased in PT-treated Ishikawa cells. Furthermore, we predicted and verified that the pro-apoptosis factor BCL2L14 is the direct target of miR-663b. Over-expression of miR-663b and knock-down of BCL2L14 counteracted the suppressing effects of PT on HTB-111 and Ishikawa cells. In addition, we evaluated the miR-663b levels in EC tissues of 51 patients using an in situ hybridization technique. With the median of the score of miR-663b as a cut-off value, these EC patients were divided into two groups, and the patients with high miR-663b expression had significantly poor prognosis.

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01:32

The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells. "IndyWatch Feed Health"

PMID:  Oncol Rep. 2017 Jul ;38(1):488-496. Epub 2017 May 30. PMID: 28560392 Abstract Title:  The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells. Abstract:  Multiple myeloma (MM) is an incurable hematologic malignancy because of its drug resistance. Pterostilbene (Pter) is found mainly in blueberries and grapes. The effects of Pter and its exact pharmacologic mechanisms on chemoresistant myeloma are not known. Herein, we investigated the anti-myeloma activity of Pter in bortezomib-resistant cell line H929R and explored the related mechanism of action for the first time. We found that Pter inhibited proliferation of H929R cells and promoted apoptosis of the cells through a caspase-dependent pathway, loss of mitochondrial membrane potential, and activation of Akt and p38 mitogen-activated protein kinase (MAPK) signaling pathways. DNA damage and S-phase arrest might be involved in Pter-related toxicity in H929R cells. Pter and the histone deacetylase inhibitors panobinostat or vorinostat inhibited proliferation of H929R cells in a synergistic manner. These data supported that Pter might be a promising natural compound for relapsed/refractory myeloma therapy, especially against myeloma resistant to bortezomib chemotherapy.

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01:11

These results indicate that methoxylated stilbenes are efficient inhibitors of glioma cell proliferation and apoptosis inducers. "IndyWatch Feed Health"

PMID:  Toxicol In Vitro. 2017 Sep ;43:69-75. Epub 2017 Jun 6. PMID: 28595835 Abstract Title:  The effect of resveratrol, its naturally occurring derivatives and tannic acid on the induction of cell cycle arrest and apoptosis in rat C6 and human T98G glioma cell lines. Abstract:  Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a potent chemopreventive and potentially cancer therapeutic agent. Since rapid metabolism limits resveratrol bioavailability, derivatives less prone to metabolic transformation are being sought and tested. We evaluated the effect of resveratrol, and its analogs (pterostilbene and 3,5,4'-trimethoxystilbene) along with tannic acid, on cell cycle and apoptosis in rat C6 and human T98G glioma cells. At concentration ranges both lower and higher than IC50 calculated based on MTT assay, all these polyphenols affected the cell cycle distribution. However, resveratrol and pterostilbene increased the percentage of the cells in S phase, while trimethoxystilbene (TMS) caused a massive accumulation of cells at the G2/M phase of the cell cycle. Tannic acid had no effect on cell cycle distribution in C6 cells, but increased the number of dead cells in both glioma cell lines. The ability to induce apoptosis by tannic acid and stilbenes was confirmed by phosphatidylserine externalization, the loss of mitochondrial membrane potential and the level of cleaved caspase-3. The apoptosis rate was most significantly increased by TMS and this was related to p53 induction. These results indicate that methoxylated stilbenes are efficient inhibitors of glioma cell proliferation and apoptosis inducers and might be considered adjuvants in glioma therapy.

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00:39

Pterostilbene 4'--glucoside protects against dss induced colitis. "IndyWatch Feed Health"

PMID:  Oxid Med Cell Longev. 2017 ;2017:9427583. Epub 2017 May 7. PMID: 28607633 Abstract Title:  Pterostilbene 4'--Glucoside Protects against DSS-Induced Colitis via Induction of Tristetraprolin. Abstract:  Pterostilbene, a dimethyl ester analog of resveratrol, has anti-inflammatory and antioxidative effects and alters cell proliferation. Tristetraprolin (TTP) promotes the degradation of proinflammatory mediators via binding to adenosine and uridine- (AU-) rich elements (ARE) located in the 3'-untranslated regions of mRNAs. Here, we utilized pterostilbene 4'--glucoside (4-PG), a compound derived from pterostilbene, to investigate whether it has anti-inflammatory effects on dextran sulfate sodium- (DSS-) induced colitis via TTP enhancement. TTP expression was increased in 4-PG dose- and time-dependent manners in RAW264.7 cells. The production of proinflammatory cytokine, such as TNF-, was reduced by 4-PG in vitro. To investigate the role of TTP in the anti-inflammatory effects of 4-PG, we used DSS-induced colitis in TTP WT and KO mice as models. The expression levels of TTP and proinflammatory cytokines were determined in serum and colon tissue. 4-PG increased the expression of TTP while suppressing proinflammatory cytokines both in vitro and in vivo. These findings suggest that treatment with 4-PG mediates the anti-inflammatory effects of 4-PG on DSS-induced colitis via enhancing TTP expression.

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00:23

Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats. "IndyWatch Feed Health"

PMID:  Life Sci. 2017 Aug 1 ;182:112-121. Epub 2017 Jun 16. PMID: 28629731 Abstract Title:  Pterostilbene ameliorates insulin sensitivity, glycemic control and oxidative stress in fructose-fed diabetic rats. Abstract:  AIMS: The present investigation was designed to explore the effectiveness of pterostilbene (PT) on insulin resistance, metabolic syndrome and oxidative stress in fructose-fed insulin resistant rats.MAIN METHODS: Age-matched, male Sprague-Dawley rats (33030g body weight) were allocated into five groups (n=10). Control (C) group received 65% cornstarch, and the diabetic (D) group received 65% fructose for eight weeks. The third group (D+PT20) received 65% fructose and PT 20mg/kg/day for eight weeks. The fourth group (D+PT40) received 65% fructose and PT 40mg/kg/day for eight weeks. The fifth group (D+M) received 65% fructose and metformin (M) 100mg/kg/day for eight weeks. PT was dissolved in 10% -cyclodextrin and given orally to rats. Several biochemical parameters were determined to assess the PT efficacy against insulin resistance, metabolic complications, and hepatic oxidative stress.KEY FINDINGS: Significantly high HOMA-IR (p

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00:12

This supports the potential use of resveratrol, pterostilbene or related compounds as adjuvants in anti-HIV pre-exposure prophylaxis formulations. "IndyWatch Feed Health"

PMID:  Antimicrob Agents Chemother. 2017 Jun 26. Epub 2017 Jun 26. PMID: 28652233 Abstract Title:  Potent inhibition of HIV-1 replication in resting CD4 T cells by resveratrol and pterostilbene. Abstract:  HIV-1 infection of resting CD4 T cells plays a crucial and numerically dominant role during virus transmission at mucosal sites and during subsequent acute replication and T cell depletion. Resveratrol and pterostilbene are plant stilbenoids associated with several health promoting benefits. Resveratrol has been shown to inhibit replication of several viruses, including herpes simplex 1 and 2, papillomaviruses, SARS virus and influenza virus. Alone, resveratrol does not inhibit HIV-1 infection of activated T cells, but it does synergize with nucleoside reverse transcriptase inhibitors in these cells to inhibit reverse transcription. Here, we demonstrate that resveratrol and pterostilbene completely block HIV-1 infection at low micromolar dose in resting CD4 T cells, primarily at the reverse transcription step. The anti-HIV effect was fully reversed by exogenous deoxynucleosides and Vpx, a simian immunodeficiency virus protein that increases dNTP levels. These findings are consistent with the reported ability of resveratrol to inhibit ribonucleotide reductase and to lower dNTP levels in cells. This study supports the potential use of resveratrol, pterostilbene or related compounds as adjuvants in anti-HIV pre-exposure prophylaxis (PrEP) formulations.

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00:09

5G California-style Needs To Be Defeated; Everyones Help Needed "IndyWatch Feed Health"

By Catherine J. Frompovich

Probably the most harmful of microwave technologies (millimeter wavesmm) are being proposed in front of homes and other buildings in the State of California and to be erected at the whim of cellular businesses and networks with no input from citizens as to placement or concerns about health issues.

California Bill SB649 has a publics comment page where your comments will be entered into the public record at the August 23, 2017 Appropriations Committee hearing. If California enacts SB649, you can be certain similar laws will spread across the country.

Here is the link to file your comment, regardless of where you live.

http://scientists4wiredtech.com/action/#form

Completing this form is the way to get your comments into the California public record, instead of on the petition! This will make a HUGE difference!

Image Credit

Catherine J Frompovich (...

00:07

Heres What a Kid Who Has Never Eaten a Gram of Sugar in Her Life Looks Like Today "IndyWatch Feed Health"

Source: Heres What a Kid Who Has Never Eaten a Gram of Sugar in Her Life Looks Like Today For more content like this visit REALfarmacy.com.

Grace Cooper is 2 and a half years old right now and she has never eaten a gram of processed sugar in her life! Shan, Graces mom, said publicly that when her daughter is old enough to understand what she likes and doesnt like, she is not going to force her to stay on strict []

Source: Heres What a Kid Who Has Never Eaten a Gram of Sugar in Her Life Looks Like Today Learn more at REALfarmacy.com - Healthy News and Information.

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Tuesday, 22 August

23:56

Pterostilbene efficiently eradicates planktonic, biofilm, and intracellular MRSA. "IndyWatch Feed Health"

PMID:  Front Microbiol. 2017 ;8:1103. Epub 2017 Jun 13. PMID: 28659908 Abstract Title:  Pterostilbene, a Methoxylated Resveratrol Derivative, Efficiently Eradicates Planktonic, Biofilm, and Intracellular MRSA by Topical Application. Abstract:  Pterostilbene is a methoxylated derivative of resveratrol originated from natural sources. We investigated the antibacterial activity of pterostilbene against drug-resistant Staphylococcus aureus and the feasibility of using it to treat cutaneous bacteria. The antimicrobial effect was evaluated using an in vitro culture model and an in vivo mouse model of cutaneous infection. The minimum inhibitory concentration (MIC) assay demonstrated a superior biocidal activity of pterostilbene compared to resveratrol (8~16-fold) against methicillin-resistant S. aureus (MRSA) and clinically isolated vancomycin-intermediate S. aureus (VISA). Pterostilbene was found to reduce MRSA biofilm thickness from 18 to 10m as detected by confocal microscopy. Pterostilbene showed minimal toxicity to THP-1 cells and was readily engulfed by the macrophages, facilitating the eradication of intracellular MRSA. Pterostilbene exhibited increased skin absorption over resveratrol by 6-fold. Topical pterostilbene application improved the abscess formation produced by MRSA by reducing the bacterial burden and ameliorating the skin architecture. The potent anti-MRSA capability of pterostilbene was related to bacterial membrane leakage, chaperone protein downregulation, and ribosomal protein upregulation. This mechanismof action was different from that of resveratrol according to proteomic analysis and molecular docking. Pterostilbene has the potential to serve as a novel class of topically applied agents for treating MRSA infection in the skin while demonstrating less toxicity to mammalian cells.

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23:32

Pterostilbene has potential to be an effective treatment for T-cell leukemia/lymphoma. "IndyWatch Feed Health"

PMID:  Biomed Res Int. 2017 ;2017:9872073. Epub 2017 Jul 12. PMID: 28785594 Abstract Title:  Pterostilbene Induces Cell Apoptosis and Cell Cycle Arrest in T-Cell Leukemia/Lymphoma by Suppressing the ERK1/2 Pathway. Abstract:  Pterostilbene is a natural 3,5-dimethoxy analog of trans-resveratrol that has been reported to have antitumor, antioxidant, and anti-inflammatory effects. T-cell leukemia/lymphoma is one of the more aggressive yet uncommon non-Hodgkin lymphomas. Although there has been increasing research into T-cell leukemia/lymphoma, the molecular mechanisms of the antitumor effects of pterostilbene against this malignancy are still largely unknown. The aim of this study is to confirm the effects of pterostilbene in T-cell leukemia/lymphoma. Jurkat and Hut-78 cells treated with pterostilbene were evaluated for cell proliferation using Cell Counting Kit-8, and apoptosis, cell cycle progression, reactive oxygen species generation, and mitochondrial membrane potential were analyzed using flow cytometry. The level of protein expression was detected by western blot. The results demonstrated that pterostilbene significantly inhibited the growth of T-cell leukemia/lymphoma cell lines in vitro and induced apoptosis in a dose- and time-dependent manner. Moreover, pterostilbene treatment markedly induced S-phase cell cycle arrest, which was accompanied by downregulation of cdc25A, cyclin A2, and CDK2. Pterostilbene also induced the generation of reactive oxygen species and the loss of mitochondrial membrane potential and inhibited ERK1/2 phosphorylation. Taken together, our study demonstrated the potential of pterostilbene to be an effective treatment for T-cell leukemia/lymphoma.

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23:21

This study explores the novel anticancer mechanism of Pterostilbenes senescence induction via the inhibition of telomerase in lung cancer cells. "IndyWatch Feed Health"

PMID:  Cell Death Dis. 2017 Aug 10 ;8(8):e2985. Epub 2017 Aug 10. PMID: 28796247 Abstract Title:  P53-dependent downregulation of hTERT protein expression and telomerase activity induces senescence in lung cancer cells as a result of pterostilbene treatment. Abstract:  Cellular senescence is characterized by permanent cell cycle arrest, triggered by a variety of stresses, such as telomerase inhibition, and it is recognized as a tumor-suppressor mechanism. In recent years, telomerase has become an important therapeutic target in several cancers; inhibition of telomerase can induce senescence via the DNA damage response (DDR). Pterostilbene (PT), a dimethyl ether analog of resveratrol, possesses a variety of biological functions, including anticancer effects; however, the molecular mechanisms underlying these effects are not fully understood. In this study, we investigated the possible mechanisms of PT-induced senescence through telomerase inhibition in human non-small cell lung cancer cells and delineated the role of p53 in senescence. The results indicated that PT-induced senescence is characterized by a flattened morphology, positive staining for senescence-associated- galactosidase activity, and the formation of senescence-associated heterochromatic foci. Telomerase activity and protein expression was significantly decreased in H460 (p53 wild type) cells compared with H1299 (p53 null) cells and p53 knockdown H460 cells (H460-p53-). A more detailed mechanisticstudy revealed that PT-induced senescence partially occurred via a p53-dependent mechanism, triggering inhibition of telomerase activity and protein expression, and leading to the DDR, S phase arrest and, finally, cellular senescence. This study is the first to explore the novel anticancer mechanismof PT senescence induction via the inhibition of telomerase in lung cancer cells.

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23:10

Vaccines made in China another ridiculous anti-vax myth "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

One of the most ridiculous myths of the anti-vaccine world is that vaccines made in China dominate the US market. I took a look at every vaccine licensed for use in America to determine where they are manufactured. Spoiler alert none are made in China. I didnt even know this was an anti-vaccine myth

Skeptical Raptor

23:05

Pterostilbene exerts anticancer activity on non-small-cell lung cancer. "IndyWatch Feed Health"

PMID:  Sci Rep. 2017 Aug 14 ;7(1):8091. Epub 2017 Aug 14. PMID: 28808300 Abstract Title:  Pterostilbene exerts anticancer activity on non-small-cell lung cancer via activating endoplasmic reticulum stress. Abstract:  Pterostilbene (PT), the natural dimethylated analog of resveratrol (RSV), is a potent anticarcinogen for non-small-cell lung cancer (NSCLC), but its anti-NSCLC mechanisms remain unclear. In this study, we show that PT treatment time- and dose-dependently enhanced the endoplasmic reticulum stress (ERS) signaling (i.e., p-PERK, IRE1, ATF4, CHOP), thus decreasing the cell viability and inducing apoptosis in human PC9 and A549 NSCLC cell lines. Moreover, the decreased migratory and adhesive abilities, downregulation of intracellular glutathione (GSH) level, enhanced reactive oxygen species (ROS) generation, Caspase 3 activity and mitochondrial membrane depolarization were observed in NSCLC cells treated with PT. These effects were reversed by CHOP siRNA which inhibited the ERS signaling pathway, but were promoted by thapsigargin (a classical ERS inducer) in vitro. Besides, in vivo studies also verify that PT exerted anticancer activity by mobilizing ERS signaling and apoptosis-related proteins, and these effects were enhanced by thapsigargin. Therefore, ERS activation may represent a new mechanism of anti-NSCLC action by PT, and a novel therapeutic intervention for lung cancer.

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22:40

Phytochemicals may serve as novel therapeutic agents for breast cancer treatment. "IndyWatch Feed Health"

PMID:  Semin Cancer Biol. 2016 Oct ;40-41:192-208. Epub 2016 Sep 5. PMID: 27609747 Abstract Title:  Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy. Abstract:  Breast cancer is the most common form of cancer diagnosed in women worldwide and the second leading cause of cancer-related deaths in the USA. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. Emerging evidence suggest the existence of cancer stem cells (CSCs), a population of cells with the capacity to self-renew, differentiate and be capable of initiating and sustaining tumor growth. In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeting breast CSCs may be better therapeutic agents for treating breast cancer and control recurrence and metastasis. Naturally occurring compounds, mainly phytochemicals have gained immense attention in recent times because of their wide safety profile, ability to target heterogeneous populations of cancer cells as well as CSCs, and their key signaling pathways. Therefore, in the present review article, we summarize our current understanding of breast CSCs and their signaling pathways, and the phytochemicals that affect these cells including curcumin, resveratrol, tea polyphenols (epigallocatechin-3-gallate, epigallocatechin), sulforaphane, genistein, indole-3-carbinol, 3, 3'-di-indolylmethane, vitamin E, retinoic acid, quercetin, parthenolide, triptolide, 6-shogaol, pterostilbene, isoliquiritigenin, celastrol, and koenimbin. These phytochemicals may serve as novel therapeutic agents for breast cancer treatment and future leads for drug development.

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22:07

Parthenolide administration alleviated some of the pathological changes in asthma. "IndyWatch Feed Health"

PMID:  Allergol Immunopathol (Madr). 2017 Jan - Feb;45(1):63-68. Epub 2016 Oct 4. PMID: 27717727 Abstract Title:  Efficacy of parthenolide on lung histopathology in a murine model of asthma. Abstract:  BACKGROUND: Parthenolide is the active constituent of the plant 'Tanacetum parthenium' (Feverfew) which has been used for centuries as a folk remedy for inflammatory conditions.AIM OF THE STUDY: In this study we aimed to investigate the effects of parthenolide in a murine model of chronic asthma.MATERIALS AND METHODS: Thirty-five BALB/c mice were divided into five groups; I (control), II (placebo), III (dexamethasone), IV (parthenolide) and V (dexamethasone and parthenolide combination). Lung histology was evaluated after treatment with the study drugs. Levels of interleukin (IL)-4 and IL-5 were determined by ELISA.RESULTS: Histologic parameters except the number of mast and goblet cells improved in the parthenolide group when compared with placebo. All parameters except basal membrane thickness and number of mast cells were improved significantly better in the group receiving dexamethasone when compared with the parthenolide group. Improvement of most of the histologic parameters was similar in Groups III and V. Interleukin-4 levels were significantly reduced in the parthenolide group when compared to the placebo group.CONCLUSION: We demonstrated that parthenolide administration alleviated some of the pathological changes in asthma. But parthenolide alone is not efficient as dexamethasone therapy and the parthenolide and dexamethasone combination also did not add any beneficial effect to the dexamethasone treatment.

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22:00

Dr Ron Unfiltered Uncensored EMF and Health. What is Glyphosate? "IndyWatch Feed Health"

Reach us at 347-989-8899 Facebook Dr Ron Unfiltered Uncensored email docronradio@gmail.com Drs Ron, Gerry and Dan with over 150 years of medical experience will discuss these topics and others that you will not hear from the main stream media. Big Pharmaceutical companies are controlling the research and funding. You can listen any no of ways. Stitcher, TuneIn, Google Play and Blubrry. Here are some links:   https://www.blubrry.com/drronunfiltereduncensored/   http://www.stitcher.com/s?fid=144321&refid=stpr   http://tunein.com/search/?query=Dr%20Ron%20Unfiltered

21:55

Do You Need a Parasite Cleanse? Make Your Own Natural Parasite Cleanse "IndyWatch Feed Health"

Tapeworm head image

Tapeworm head

by Paul Fassa
Health Impact News

Whenever parasites are mentioned it is usually considered a third world or developing nation issue. Phrases such as lovely place, nice people, but dont drink the water are common jokes that have some basis in truth.

Although our culture is programmed to think all illnesses are derived from viruses and some bacteria, the USA also has its share of parasite issues. The CDC openly admits this in a May 2017 report on its website:

Outbreaks of a parasitic infection linked to swimming pools and water playgrounds are increasingly being reported to CDC, with twice as many outbreaks in 2016 as in 2014. (Source)

Notice the word outbreaks is used, not cases. The outbreaks recorded from a few states with using a recently installed tracking system involved hundreds of cases reported, overflowing into the thousands range.

This specific parasite invasion was from the microscopic Cryptosporidium, aka Crypto, which has a capacity for surviving prescribed pool chlorine content requirements. The chlorine levels in municipal tap water cant handle this parasite either.

There was a neti-pot scare a few years ago when a few folks died from a brain eating amoeba after using their neti-pot with tap water or swimming in fresh water lakes of ponds during summer months. (Source)

So maybe its time to focus a bit more on parasites instead of viruses that sometimes dont really exist and are usually more difficult to spread than parasites?

...

21:52

Parthenolide may provide a beneficial therapeutic strategy for acute lung injury. "IndyWatch Feed Health"

PMID:  Arch Pharm Res. 2016 Dec ;39(12):1716-1725. Epub 2016 Oct 18. PMID: 27757770 Abstract Title:  Protective effect of sesquiterpene lactone parthenolide on LPS-induced acute lung injury. Abstract:  Acute lung injury (ALI) is a respiratory failure disease and the major source of mortality in the critically ill patients. The main pathological changes involved in ALI include the excessive recruitment and activation of neutrophils by increased pro-inflammatory mediators. However, any specific therapy for ALI has not been developed. The objective of this study was to investigate protective effects of parthenolide, a sesquiterpene lactone produced in feverfew, on LPS-induced lung injury. In the present study, parthenolide treatment reduced infiltration of inflammatory cells, airway permeability and production of pro-inflammatory cytokines in LPS-induced ALI mouse model. Further, LPS-stimulated phosphorylation of NF-B, the key regulatory transcription factor in ALI, was inhibited by parthenolide treatment in lung epithelial BEAS-2B cells and alveolar macrophage MH-S cells. These results suggest that parthenolide may provide a beneficial therapeutic strategy for ALI.

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21:52

Delhi: Handpumps, tubewells to be sealed in areas where groundwater is contaminated "IndyWatch Feed Health"

The state government would soon crack down on extraction of groundwater in areas where the water has been found to be contaminated.

Earlier this year, a report placed in the Lok Sabha revealed that groundwater in several parts of Delhi is contaminated with arsenic and fluoride. Heavy metals such as lead, cadmium and chromium have also been found in some areas.

To prevent people from drinking contaminated water, we will soon seal the handpumps and tube wells in areas where we find groundwater contamination, said a senior official of the Delhi Pollution Control Committee (DPCC).

The DPCC has also urged the Central Ground Water Board and the Delhi Jal Board to carry out a comprehensive survey to identify areas where groundwater is contaminated with elements and metals above the permissible limit prescribed by the Bureau of Indian Standards.

The report is expected to be submitted by this month. Once the report comes in we would direct the civic bodies and the DJB to seal the handpumps and tube wells, said a senior DPCC official.

CGWB sources said that most of the pollutants such as Nitrates and heavy metals come from industrial effluents that seep into the groundwater.

Earlier this month, the National Green Tribunal had set up a committee headed by the state environment secretary while hearing a case on groundwater contamination published in the Hindustan Times in June 2015.

The committee is also preparing a plan on how groundwater can be extracted from some parts of the city where groundwater level is very high. The end users have to be also identified.

The NGT had earlier suggested that if the groundwater is polluted, it could be sent to water purifier plants of the DJB and then supplied to water scarce areas. If the water remains contaminated even after purification then it could be sold to users such as the Delhi Metro Rail Corporation.

The basements of many buildings are being affected where the groundwater level is too high. In some areas such as Sukhdev Vihar, New Friends Colony, Okhla and Siddhartha Extension the water table has been found to be very high, said an official of the DJB.

*Original article online at http://www.hindustantimes.com/delhi-news/delhi-handpumps-tubewells-to-be-sealed-in-areas-where-groundwater-is-contaminated/story-c46p5SsZ53QF2Kfb9cfDdI.html

21:30

These findings unveil a novel mechanism of drug action by parthenolide in osteosarcoma cancer cells. "IndyWatch Feed Health"

PMID:  Cell Physiol Biochem. 2016 ;40(1-2):146-154. Epub 2016 Nov 18. PMID: 27855364 Abstract Title:  Parthenolide Induces Reactive Oxygen Species-Mediated Autophagic Cell Death in Human Osteosarcoma Cells. Abstract:  BACKGROUND AND AIM: Osteosarcoma is a devastating tumor of bone, primarily affecting adolescents. Parthenolide, a naturally occurring small molecule that interferes with NF-B signaling, has recently attracted considerable attention because of its pharmacological action involving anti-cancer effects. However, the mechanism of the cytotoxic effect exerted by parthenolide on tumor cells is not clearly defined today.METHODS: In this study, the effects of parthenolide were evaluated and characterized in human osteosarcoma cancer cell. Cell viability was assessed by CCK-8. Apoptosis was assessed by Annexin V-FITC/PI Flow cytometry assay. Relative quantitative real-time PCR and western blot were used to determine the expressions of genes and proteins.RESULTS: Our results suggest that parthenolide did not cause caspase-dependent cell death in osteosarcoma cancer cells, as indicated by the absence of significant early apoptosis as well as caspase-3 cleavage. Instead, parthenolide increased the autophagy and mitophagy, as characterized by increased PINK1 and Parkin translocation to mitochondria and enhanced autophagy proteins. The induction of autophagy by parthenolide was associated with the increase of reactive oxygen species (ROS). ROS antioxidants N-acetylcysteine (NAC) attenuated parthenolide-induced autophagy activity.CONCLUSIONS: Our findings unveil a novel mechanism of drug action by parthenolide in osteosarcoma cancer cells and suggest a potential value of treating osteosarcoma cancer through a caspase-independent autophagic cell death by ROS activation.

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21:03

Parthenolide has the ability to target multiple pathways that regulate the self-renewal, growth and survival of leukemia stem cells. "IndyWatch Feed Health"

PMID:  Mol Cancer. 2017 Jan 30 ;16(1):13. Epub 2017 Jan 30. PMID: 28137265 Abstract Title:  Targeting acute myeloid leukemia stem cell signaling by natural products. Abstract:  Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15-20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of somatically acquired genetic changes, altering self-renewal, proliferation, and differentiation of hematopoietic progenitor cells, resulting in uncontrolled clonal proliferation of malignant progenitor myeloid cells in the bone marrow, peripheral blood, and occasionally in other body tissues. Treatment with modern chemotherapy regimen (cytarabine and daunorubicin) usually achieves high remission rates, still majority of patients are found to relapse, resulting in only 40-45% overall 5 year survival in young patients and less than 10% in the elderly AML patients. The leukemia stem cells (LSCs) are characterized by their unlimited self-renewal, repopulating potential and long residence in a quiescent state of G0/G1 phase. LSCs are considered to have a pivotal role in the relapseand refractory of AML. Therefore, new therapeutic strategies to target LSCs with limited toxicity towards the normal hematopoietic population is critical for the ultimate curing of AML. Ongoing research works with natural products like parthenolide (a natural plant extract derived compound) and itsderivatives, that have the ability to target multiple pathways that regulate the self-renewal, growth and survival of LSCs point to ways for a possible complete remission in AML. In this review article, we will update and discuss various natural products that can target LSCs in AML.

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20:46

7 Signs You Need To Start Consuming Less Protein Right Away "IndyWatch Feed Health"

This fantastic article is written by Dr. Josh Axe. Check out his website or follow him on Facebook for more great information! Our bodies need protein to build muscle mass, feel full, promote healthy brain function, and so much more. Unfortunately, there is a lot of confusion about protein....

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The post 7 Signs You Need To Start Consuming Less Protein Right Away appeared first on Healthy Holistic Living.

20:44

These results demonstrate that parthenolide potentiates the efficacy of balsalazide. "IndyWatch Feed Health"

PMID:  Mol Cancer Res. 2017 Feb ;15(2):141-151. Epub 2016 Nov 14. PMID: 28108625 Abstract Title:  Combined Parthenolide and Balsalazide Have Enhanced Antitumor Efficacy Through Blockade of NF-B Activation. Abstract:  : Balsalazide is a colon-specific prodrug of 5-aminosalicylate that is associated with a reduced risk of colon cancer in patients with ulcerative colitis. Parthenolide, a strong NF-B inhibitor, has recently been demonstrated to be a promising therapeutic agent, promoting apoptosis of cancer cells. In the current study, the antitumor effect of balsalazide combined with parthenolide in human colorectal cancer cells and colitis-associated colon cancers (CAC) was investigated. The results demonstrate that the combination of balsalazide and parthenolide markedly suppress proliferation, nuclear translocation of NF-B, IB- phosphorylation, NF-B DNA binding, and expression of NF-B targets. Apoptosis via NF-B signaling was confirmed by detecting expression of caspases, p53 and PARP. Moreover, treatment of a CAC murine model with parthenolide and balsalazide together resulted in significant recovery of body weight and improvement in histologic severity. Administration of parthenolide and balsalazide to CAC mice also suppressed carcinogenesis as demonstrated by uptake of 18F-fluoro-2-deoxy-D-glucose (FDG) using micro-PET/CT scans. These results demonstrate that parthenolide potentiates the efficacy of balsalazide through synergistic inhibition of NF-B activation and the combination of dual agents prevents colon carcinogenesis from chronic inflammation.IMPLICATIONS: This study represents the first evidence that combination therapy with balsalazide and parthenolide could be a new regimen for colorectal cancer treatment. Mol Cancer Res; 15(2); 141-51.2016 AACR.

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20:39

Judge Orders Children Home in Kansas Case with Navy Dad Who used Medical Cannabis "IndyWatch Feed Health"

Part of the Schwab family during a visit. Photo source: Free the Schwab Children Facebook page.

by Health Impact News/MedicalKidnap.com Staff

Raymond and Amelia Schwab didnt know what to expect when they went into a Kansas courtroom on Tuesday, August 15, 2017. The Colorado couple has been fighting to get their children back since the Department for Children and Families (DCF) seized custody of them in April 2015. During that time, they have been told that their parental rights would be terminated, that their children would be returned home, and everything in between.

It has been an emotional roller coaster, and 5 of their 6 children have been in foster care for more than 2 years. (Their oldest son was 19 when his younger siblings were taken and therefore avoided foster care.)

Raymond Schwab (also known as Seraphim), an honorably discharged Navy veteran, and his wife Amelia took to Facebook Live with an update for thousands of their followers, many of whom have been praying for their children to be returned to the family.

The update was a mixture of good news and bad news the children are supposed to be returned home, just not immediately. They were told that the children should be home by Christmas.

Children Seized Over False Allegations, Which Turned into a Battle over Medicinal Cannabis

The Schwabs have always maintained that their children should never have been taken from them in the first place. As we reported in our original coverage of their story, there were false allegations made against the homeschooling parents. By July 10, less than 3 months after the children were taken, DCF knew that the allegations were unsubstantiated.

See original story, which contains the Notice of Department Findings of the unsubstantiated allegations:

Navy Dad Goes on Hunger Strike in Kansas Until State-Kidnapped Children are Returned or He Starves to Death...

20:07

Israels fluoridation supply expected to be restored after three years "IndyWatch Feed Health"

Note from Fluoride Action Network: The former Minister of Health, Yael German of the Yesh Atid political party, was smart and progressive and in taking her office in 2013 she began a process than ended mandatory fluoridation in Israel. She replaced Benjamin Netanyahu, the Prime Minister of Israel, who was the nominal Minister of Health from 2009 to 2013 (and for 3 months in 2015). In reality this position was held by orthodox Rabbi Yaakov Litzman of the United Torah Judaism political party. The reason that Litzman couldnt be named as Minister of Health was because he was a rabbi. However that issue was settled in 2015 and his name is now acknowledged as Minister. One of the first issues Rabbi Litzman took on when he was reappointed by Netanyahu was to bring back the fluoridation of drinking water in Israel. However, as the article below notes, there are still some obstacles in place before this can happen.

YAACOV LITZMAN

YAACOV LITZMAN. (photo credit:YOEL LEVI)

The cost of fluoridation adds just a few agorot per cubic meter to water bills.

Two years and two months have passed since Health MinisterYaacov Litzman promised to restore fluoridation canceled by his predecessor Yael German of the nations water supply. In the meantime, the dental health of children, especially those in low-income families that eat junk food and dont take care of their teeth properly has suffered, according to experts.

When German and her party were voted out of power in the last Knesset election, reversing her cancellation of fluoridation was one of the first steps Litzman planned to implement, but the problem has dragged on.

In a few months, fluoridation will return, according to Udi Kalin...

19:58

Parthenolide can serve as a potential chemotherapeutic agent for pancreatic cancer. "IndyWatch Feed Health"

PMID:  Onco Targets Ther. 2017 ;10:453-461. Epub 2017 Jan 23. PMID: 28176967 Abstract Title:  Parthenolide suppresses pancreatic cell growth by autophagy-mediated apoptosis. Abstract:  Pancreatic cancer is an aggressive malignancy and is unresponsive to conventional chemotherapies. Parthenolide, a sesquiterpene lactone isolated from feverfew, has exhibited potent anticancer effects against various cancers. The purpose of this report was to investigate the effect and underlying mechanism of parthenolide in human pancreatic cancer Panc-1 and BxPC3 cells. The results demonstrated that parthenolide suppressed the growth and induced apoptosis of Panc-1 and BxPC3 pancreatic cancer cells with the half maximal inhibitory concentration (IC50) ranging between 7 and 9M after 24 h of treatment. Significant autophagy was induced by parthenolide treatment in pancreatic cancer cells. Parthenolide treatment concentration-dependently increased the percentage of autophagic cells and significantly increased the expression levels of p62/SQSTM1, Beclin 1, and LC3II in Panc-1 cells. Punctate LC3II staining confirmed autophagy. Furthermore, inhibiting autophagy by chloroquine, 3-methyladenine, or LC3II siRNA significantly blocked parthenolide-induced apoptosis, suggesting that parthenolide induced apoptosis through autophagy in this study. In conclusion, these studies established that parthenolide inhibits pancreatic cell growth by autophagy-mediated apoptosis. Data of the present study suggest that parthenolide can serve as a potential chemotherapeutic agent for pancreatic cancer.

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19:53

Judge Orders Children Home in Kansas Case with Navy Dad Who used Medical Cannabis "IndyWatch Feed Health"

Part of the Schwab family during a visit. Photo source: Free the Schwab Children Facebook page.

by Health Impact News/MedicalKidnap.com Staff

Raymond and Amelia Schwab didnt know what to expect when they went into a Kansas courtroom on Tuesday, August 15, 2017. The Colorado couple has been fighting to get their children back since the Department for Children and Families (DCF) seized custody of them in April 2015. During that time, they have been told that their parental rights would be terminated, that their children would be returned home, and everything in between.

It has been an emotional roller coaster, and 5 of their 6 children have been in foster care for more than 2 years. (Their oldest son was 19 when his younger siblings were taken and therefore avoided foster care.)

Raymond Schwab (also known as Seraphim), an honorably discharged Navy veteran, and his wife Amelia took to Facebook Live with an update for thousands of their followers, many of whom have been praying for their children to be returned to the family.

The update was a mixture of good news and bad news the children are supposed to be returned home, just not immediately. They were told that the children should be home by Christmas.

Children Seized Over False Allegations, Which Turned into a Battle over Medicinal Cannabis

The Schwabs have always maintained that their children should never have been taken from them in the first place. As we reported in our original coverage of their story, there were false allegations made against the homeschooling parents. By July 10, less than 3 months after the children were taken, DCF knew that the allegations were unsubstantiated.

See original story, which contains the Notice of Department Findings of the unsubstantiated allegations:

Navy Dad Goes on Hunger Strike in Kansas Until State-Kidnapped Children are Returned or He Starves to Death

...

19:33

Worst Cholera Outbreak in the World Result of KSAs War in Yemen "IndyWatch Feed Health"

cholera yemen

By Brandon Turbeville

Saudi Arabias war of aggression in Yemen has brought yet a new weapon to bear against the Yemeni people: cholera.

With the relentless bombing, the targeting of civilians and civilian areas, the destruction of infrastructure and an embargo on food and medicine, conditions are ripe for disease.

The spread of cholera is worse in areas controlled by the Hutis. This is because these are the areas that under aerial bombardment and blockade.

In fact 77.7% of cholera cases and 80.7% of deaths from cholera occur in Huti controlled areas.

Researchers Jonathan Kennedy, Andrew Harmer, and David McCoy from Queen Mary University of London recently published an article in the Lancet Global Health where they addressed what has been deemed the worst cholera outbreak in the world.

Both sides have been accused of disregarding the wellbeing of civilians and breaching international humanitarian law, the researchers say. But the government and Saud...

19:30

The Totalitarian New World Order Tactics Of The Pennsylvania Public Utility Commission "IndyWatch Feed Health"

By Catherine J. Frompovich

Fox43 News has documented the outrageous and inhumane actions Pennsylvania utility companies are permitted to implement by the PA Public Utility Commission (PA PUC) regarding the callous actions forced upon a Dover, York County, Pennsylvania, resident who previously suffered a traumatic brain injury. Even a letter from her physician didnt forestall the installation of the health-dangerous AMI Smart Meter!

The inhumanness of the PA PUCs illegal interpretation of SB2200/Act 129, wherein Legislators said they were not making AMI Smart Meters mandatory, is causing terrible adverse health effects for thousands of people from AMI Smart Meters, which operate on microwave energies and pump out dramatic voluminous non-thermal radiation waves causing health problems or even making them electromagnetically hypersensitive (EHS), which medical doctors diagnose as idiopathic environmental intolerance (IEI).

Heres the Fox43 News report, which ought to get all Pennsylvanians more than angry, especially those who have autistic children and family members with health problems.

...

19:12

Chargemaster Rap "IndyWatch Feed Health"

Hospital prices are not determined by supply and demand but are purely administrative decisions. These decisions are made by the institutions Chargemaster. Hospitals are not required to make their Chargemaster public. Read Full Article.

19:08

Parthenolide was found to be efficient in inducing cell death in both cell lines tested. "IndyWatch Feed Health"

PMID:  Cell Oncol (Dordr). 2017 Jun ;40(3):263-279. Epub 2017 Apr 20. PMID: 28429280 Abstract Title:  Synergistic anti-cancer effects of epigenetic drugs on medulloblastoma cells. Abstract:  PURPOSE: Medulloblastomas are aggressive brain malignancies. While considerable progress has been made in the treatment of medulloblastoma patients with respect to overall survival, these patients are still at risk of developing neurologic and cognitive deficits as a result of anti-cancer therapies. It is hypothesized that targeted molecular therapies represent a better treatment option for medulloblastoma patients. Therefore, the aim of the present study was to test a panel of epigenetic drugs for their effect on medulloblastoma cells under mild hypoxic conditions that reflect the physiological concentrations of oxygen in the brain.METHODS: Protein levels of histone deacetylase 1 (HDAC1) and DNA methyltransferase 1 (DNMT1) in medulloblastoma-derived cells (Daoy and D283 Med), as well as in developing and differentiated brain cells, were determined and compared. Class I and II histone deacetylase inhibitors (HDACi) and a DNMT inhibitor, 5-aza-2'-deoxycytidine (5-aza-dC), were applied to Daoy and D283 Med cells, and their effects were studied using viability, apoptosis and cancer sphere assays.RESULTS: We found that in HDAC1 and DNMT1 overexpressing medulloblastoma-derived cells, cell death was induced under various epigenetic drug conditions tested. At low HDACi concentrations, however, a pro-proliferative effect was observed. Parthenolide, a drug that affects cancer stem cells, was found to be efficient in inducing cell death in both cell lines tested. In contrast, we found that Daoy cells were more resistant to 5-aza-dC than D283 Med cells. When suberoylanilide hydroxamic acid (SAHA) and parthenolide were individually applied to both cell lines in combination with 5-aza-dC, a synergistic effect on cell survival was observed.CONCLUSIONS: Our current results suggest that the application of HDACi in combination with drugs that target DNMT may represent a promising option for the treatment of medulloblastoma.

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18:44

Parthenolide selectively sensitizes prostate tumor tissue to radiotherapy while protecting healthy tissues in vivo. "IndyWatch Feed Health"

PMID:  Radiat Res. 2017 May ;187(5):501-512. Epub 2017 Mar 3. PMID: 28398879 Abstract Title:  Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo. Abstract:  Radiotherapy is widely used in cancer treatment, however the benefits can be limited by radiation-induced damage to neighboring normal tissues. Parthenolide (PTL) exhibits anti-inflammatory and anti-tumor properties and selectively induces radiosensitivity in prostate cancer cell lines, while protecting primary prostate epithelial cell lines from radiation-induced damage. Low doses of radiation have also been shown to protect from subsequent high-dose-radiation-induced apoptosis as well as DNA damage. These properties of PTL and low-dose radiation could be used to improve radiotherapy by killing more tumor cells and less normal cells. Sixteen-week-old male Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) and C57BL/6J mice were treated with PTL (40 mg/kg), dimethylaminoparthenolide (DMAPT, a PTL analogue with increased bioavailability) (100 mg/kg), or vehicle control three times over one week prior to combinations of low (10 mGy) and high (6 Gy) doses of whole-body X-irradiation. Tissues were analyzed for apoptosis at a range of time points up to 72 h postirradiation. Both PTL and DMAPT protected normal tissues, but not prostate tumor tissues, from a significant proportion of high-dose-radiation-induced apoptosis. DMAPT provided superior protection compared to PTL in normal dorsolateral prostate (71.7% reduction, P = 0.026), spleen (48.2% reduction, P = 0.0001) and colorectal tissue (38.0% reduction, P = 0.0002), and doubled radiation-induced apoptosis in TRAMP prostate tumor tissue (101.3% increase, P = 0.039). Both drugs induced the greatest radiosensitivity in TRAMP prostate tissue in areas with higher grade prostatic intraepithelial neoplasia (PIN) lesions. A 10 mGy dose delivered 3 h prior to a 6 Gy dose induced a radioadaptive apoptosis response in normal C57Bl/6J prostate (28.4% reduction, P = 0.045) and normal TRAMP spleen (13.6% reduction, P = 0.047), however the low-dose-adaptive radioprotection did not significantly add to the PTL/DMAPT-induced protection in normal tissues, nor did it affect tumor kill. These results support the use of the more bioavailable DMAPT and low-dose radiation, alone or in combination as useful radioprotectors of normal tissues to alleviate radiotherapy-induced side-effects in patients. The enhanced radiosensitisation in prostate tissues displaying high-grade PIN suggests that DMAPT also holds promise for targeted therapy of advanced prostate cancer, which may go on to become metastatic. The redox mechanisms involved in the differential radioprotection observed here suggest that increased radiotherapy efficacy by DMAPT is more...

18:35

Hospitals: Crony Capitalist Mess "IndyWatch Feed Health"

The horror stories are legion.

A 64-year-old woman had chest pains and was taken by ambulance to a non-profit hospital. After three hours of tests, she was told she had indigestion and sent home. She did not have insurance. Her bill was $21,000.

Another patient was told he had non-Hodgkins lymphoma. He went to MD Anderson Cancer Center in Houston. The total cost for an examination, an initial dose of chemotherapy and a treatment plan (fee due in advance) was $83,900.

This patient was charged $1.50 for a single, generic Tylenol tablet, when an entire bottle can be purchased for that price elsewhere. A chest X-ray cost him $283, though the hospital typically charges Medicare patients $20 for the same test.

The son of an ANH-USA board member was throwing up and was taken to an emergency room by concerned friends. The initial bill was $8,000. The insurance company reduced the price to just under $2,000, which didnt even include the doctors bill. An uninsured patient would have been charged the full $8,000.

Different hospitals charge vastly different prices even from other facilities in the same area. One hospital in New Jersey, for example, charges nearly $100,000 for a procedure to treat chronic obstructive pulmonary disease; thirty miles away a different hospital charges $7,000.

For consumers, this is a bewildering, Kafkaesque system that is often impossible to navigate. How did we get here?

The vehicle behind these absurd prices is the Chargemaster, a hospital-specific compendium of all the items that a hospital can bill a patient for (or a third-party payer like an insurance company or Medicare). The prices are not determined by supply and demand but are purely administrative decisions. Hospitals are not required to make their Chargemaster public.

Heres how it works, or rather doesnt work. Insurance companies work out deals each year with hospitals to determine what insurance will pay for hospital services, on the premise that insurers have a lot of patients that will be needing hospitalization. So Blue Cross/Blue Shield can negotiate a reduced rate for its members that is significantly lower than the price listed in the Chargemaster.

Medicare works a bit differently. By law, Medicare payments are supposed to approximate a hospitals cost of providing a service, including overhead, salaries, and equipment. But nobody really knows or cares what these costs are.

This system works brilliantlyfor hospitals. According to ...

18:34

How to Reduce Exposure to Pesticides, Herbicides, and Insecticides "IndyWatch Feed Health"

This article is shared with permission from our friends at Be Well, by Dr. Frank Lipman. Much of my practice centers around guiding people back to health by giving them the tools they need to make it happen. One of the first steps on the wellness path involves reducing your toxic...

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The post How to Reduce Exposure to Pesticides, Herbicides, and Insecticides appeared first on Healthy Holistic Living.

18:34

Parthenolide might be a candidate agent for preventing NAFLD due to its anti-inflammatory and anti-oxidative potency. "IndyWatch Feed Health"

PMID:  Immunopharmacol Immunotoxicol. 2017 Aug ;39(4):233-242. Epub 2017 May 30. PMID: 28555525 Abstract Title:  Hepatoprotective effect of parthenolide in rat model of nonalcoholic fatty liver disease. Abstract:  CONTEXT: The active ingredients of traditional medical herbs have been the focus of scientific interests.OBJECTIVE: This study was designed to explore the mechanisms of actions of parthenolide on nonalcoholic fatty liver disease (NAFLD).MATERIALS AND METHODS: Thirty-five male Wistar rats were fed high-fat diet (HFD) for eight weeks with or without an intraperitoneal injection of parthenolide to develop NAFLD. Liver triacylglycerol (TG), total antioxidant capacity (TAC), total oxidative status (TOS), thiobarbituric acid reactant substances (TBARs), total thiol groups and tumor necrosis factor alpha (TNF-) and cytochrome P4502E1 (CYP2E1) levels as well as liver ALT, AST and catalase activities were determined. In addition, quantitative real-time PCR was performed to obtain hepatic gene expression levels of TNF-, CYP2E1 and nuclear factor-B (NF-B).RESULTS: HFD caused a significant weight gain and increased liver TG content as well as alteration in ALT and AST activities, which were attenuated after administration of parthenoide (p

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18:14

Oral administration of parthenolide completely prevented tumor formation and significantly reduced the severity of histopathological changes. "IndyWatch Feed Health"

PMID:  Mol Cell Biochem. 2017 Aug 12. Epub 2017 Aug 12. PMID: 28801714 Abstract Title:  Parthenolide attenuates 7,12-dimethylbenz[a]anthracene induced hamster buccal pouch carcinogenesis. Abstract:  Over the decades, the survival rates for oral cancer have not improved despite development in novel diagnostic and therapeutic strategies. Therefore, the present study is aimed at investigating the chemopreventive potential of parthenolide in DMBA-induced hamster buccal pouch carcinogenesis. The hamsters were divided into 4 groups (n = 6/group). Group I was treated as control. Groups II and III were painted with a solution of 0.5% DMBA three times per week for 14 weeks on the left buccal pouches. In addition, group III were orally administrated with parthenolide 2 mg/kg b.w on days alternate to the DMBA application. Group IV received only parthenolide. At the end of 14th week all hamsters were sacrificed. Buccal tissues from all hamsters were evaluated for histopathology. Biochemical studies were carried out using plasma, liver, and buccal mucosa of control and experimental hamsters. Gene and protein expression studies of apoptotic markers p53, Bcl-2, and Bax were performed. The results showed 100% tumor formation and marked alterations in histopathology, status of detoxification enzymes, lipid peroxidation, and antioxidant profile in group II hamsters. Oral administration of parthenolide completely prevented tumor formation and significantly reduced the severity of histopathological changes in group III hamsters. The status of detoxification enzymes, lipid peroxidation, and antioxidants were significantly restored in parthenolide treated group compared to group II hamsters. The apoptotic gene p53 and antiapoptotic gene Bcl-2 were significantly down regulated; whereas, pro-apoptotic gene Bax was up regulated in group III hamsters compared to group II. The results of the present study suggest that parthenolide have potent chemopreventive, antioxidant, and apoptotic effect in DMBA-induced oral carcinogenesis.

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18:03

Parthenolide modulates immune response in cells from C57BL/6 mice induced with experimental autoimmune encephalomyelitis. "IndyWatch Feed Health"

PMID:  Planta Med. 2017 May ;83(8):693-700. Epub 2016 Dec 20. PMID: 27997959 Abstract Title:  Parthenolide Modulates Immune Response in Cells from C57BL/6 Mice Induced with Experimental Autoimmune Encephalomyelitis. Abstract:  Multiple sclerosis is a chronic inflammatory and autoimmune disease of the central nervous system that affects more than 2.5 million people worldwide. Experimental autoimmune encephalomyelitis is a murine autoimmune disease used to study multiple sclerosis. Parthenolide, a natural sesquiterpene lactone found in Tanacetum parthenium L., is known for its strong anti-inflammatory activity. Herein, we have investigated the in vitro immunomodulatory effects of parthenolide on cytokine production and nitric oxide in cultured cells from myelin oligodendrocyte glycoprotein 35-55 amino acid peptide mice. Experimental autoimmune encephalomyelitis was induced in C57BL/6 mice with myelin oligodendrocyte glycoprotein 35-55 amino acid peptide, and parthenolide was isolated from T. parthenium. Splenocytes and peritoneal cells were obtained from experimental autoimmune encephalomyelitis-induced mice and incubated with parthenolide (1, 5, and 20M). After in vitro treatment with parthenolide, supernatants were collected, and nitric oxide and cytokines were measured. The results suggested that parthenolide may regulate the activity of Th17 and Th1 cells, mainly by decreasing IL-17, TNF-, and interferon gamma production. This modulation may be related to the lower levels of IL-12p40 and IL-6 after treatment with parthenolide. It was shown, for the first time, that parthenolide presents in vitro immunomodulatory effects on inflammatory mediators produced by cells from experimental autoimmune encephalomyelitis-induced mice.

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17:56

Can Peanut Allergies Be Cured? Scientists Say YES using Probiotics "IndyWatch Feed Health"

peanut allergiesThe prevalence of peanut allergies continues to skyrocket worldwide. In fact, it remains the fastest growing food allergy at the present time. Frequency in US schoolchildren alone more than tripled from 1997 to 2008. Unlike other food allergies, a peanut allergy is seldom outgrown and is also one of the most dangerous. Those suffering its effects typically must carry an EpiPen for emergency treatment of anaphylaxis.

In attempts to limit life threatening exposure, many schools have banned peanuts and all products containing them. This includes lunchboxes as well as school cafeterias and vending machines. Unrefined peanut oil and foods cooked in it are also a risk as some of the peanut protein can remain in the fat.

Heres the good news!

Researchers claim that those suffering from peanut allergies have hope of recovery using a special type of therapeutic probiotic! Whats more, the potential recovery is long-term with 70% of those treated still allergy free after four years.(...)
Read the rest of Can Peanut Allergies Be Cured? Scientists Say YES using Probiotics (414 words)

The post Can Peanut Allergies Be Cured? Scientists Say YES using Probiotics appeared first on The Healthy Home Economist.

17:44

Parthenolide attenuates cerebral ischemia/reperfusion injury. "IndyWatch Feed Health"

PMID:  Biomed Pharmacother. 2017 May ;89:1159-1165. Epub 2017 Mar 24. PMID: 28314243 Abstract Title:  Parthenolide attenuates cerebral ischemia/reperfusion injury via Akt/GSK-3 pathway in PC12 cells. Abstract:  Parthenolide (PN), a sesquiterpene lactone isolated from the herbal medicine feverfew (Tanacetum parthenium), was reported to possess neuroprotective activity. However, the neuroprotective effect of PN against cerebral ischemia/reperfusion (I/R) injury remains unclear. Therefore, the aim of the present study was to explore the neuroprotective effects of PN against oxygen-glucose deprivation (OGD)-induced apoptosis in PC12 cells and the underlying mechanisms. Our results demonstrated that PN ameliorated OGD/R-evoked neuronal injury and oxidative stress in PC12 cells. In addition, PN notably decreased HIF-1 expression, as well as inhibited apoptosis in PC12 cells after OGD/R. Furthermore, PN pretreatment significantly enhanced the phosphorylation of Akt and GSK-3 in PC12 cells exposed to OGD/R. In conclusion, the present study demonstrated that PN exhibits a neuroprotective effect against OGD/R through activation of the Akt/GSK-3 signaling pathway. Our findings suggest that PN has the potential to serve as a novel therapeutic agent for cerebral I/R injury.

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17:36

Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth. "IndyWatch Feed Health"

PMID:  Oncotarget. 2017 Apr 4 ;8(14):23436-23447. PMID: 28423582 Abstract Title:  Parthenolide suppresses non-small cell lung cancer GLC-82 cells growth via B-Raf/MAPK/Erk pathway. Abstract:  Non-small cell lung cancer (NSCLC), one type of lung cancer, owns high rates of morbidity and mortality. B-Raf is one of the promising oncogenic drivers of NSCLC. Parthenolide, a natural product, is mainly extracted from the herbal plant Tanacetum parthenium. The effect of parthenolide on NSCLC cells and its potential as B-Raf inhibitor were studied in this study. It's shown that parthenolide exhibited the strong cytotoxicity against NSCLC cells with IC50 ranging from 6.07 0.45 to 15.38 1.13 M. Parthenolide was also able to induce apoptosis, suppress proliferation and invasion in NSCLC cells. In terms of the involved mechanism, parthenolide suppressed GLC-82 cell response via targeting on B-Raf and inhibiting MAPK/Erk pathway signaling. The effect of parthenolide on B-Raf and MAPK/Erk pathway was further confirmed by RNA interference of B-Raf. Decreased expression of c-Myc in protein and mRNA level was also discovered, which is considered as the further downstream of the MAPK/Erk pathway. In addition, STAT3 activity inhibition by parthenolide contributedto its effect on GLC-82 cells, which is independent of PI3K pathway signaling and GSK3. All above provide an insight to understand the action of parthenolide as a potential B-Raf inhibitor in treatment of NSCLC.

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17:26

Parthenolide is a potential novel therapeutic agent for aggressive colorectal cancer treatment. "IndyWatch Feed Health"

PMID:  Intest Res. 2017 Apr ;15(2):174-181. Epub 2017 Apr 27. PMID: 28522946 Abstract Title:  Parthenolide promotes apoptotic cell death and inhibits the migration and invasion of SW620 cells. Abstract:  BACKGROUND/AIMS: Parthenolide (PT), a principle component derived from feverfew (Tanacetum parthenium), is a promising anticancer agent and has been shown to promote apoptotic cell death in various cancer cells. In this study, we focused on its functional role in apoptosis, migration, and invasion of human colorectal cancer (CRC) cells.METHODS: SW620 cells were employed as representative human CRC cells. We performed the MTT assay and cell cycle analysis to measure apoptotic cell death. The wound healing, Transwell migration, and Matrigel invasion assays were performed to investigate the effect of PT on cell migration/invasion. Western blotting was used to establish the signaling pathway of apoptosis and cell migration/invasion.RESULTS: PT exerts antiproliferative effect and induces apoptotic cell death of SW620 cells. In addition, PT prevents cell migration and invasion in a dose-dependent manner. Moreover, PT markedly suppressed migration/invasion-related protein expression, including E-cadherin,-catenin, vimentin, Snail, cyclooxygenase-2, matrix metalloproteinase-2 (MMP-2), and MMP-9 in SW620 cells. PT also inhibited the expression of antiapoptotic proteins (Bcl-2 and Bcl-xL) and activated apoptosis terminal factor (caspase-3) in a dose-dependent manner.CONCLUSIONS: Our results suggest that PT is a potential novel therapeutic agent for aggressive CRC treatment.

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17:02

Vitamin D deficiency is associated with risk of breast cancer. "IndyWatch Feed Health"

PMID:  Pak J Med Sci. 2017 May-Jun;33(3):645-649. PMID: 28811787 Abstract Title:  Association between Vitamin D deficiency and Breast Cancer. Abstract:  OBJECTIVE: To determine the association between vitamin D deficiency and breast cancer.METHODS: This case control study included 94 female patients aged 20-75 years of any marital status and parity. Newly diagnosed 42 breast cancer patients who presented to surgical OPD of Dow University Hospital from Jan 2016 to June 2016 were included into the study as"cases"after informed consent. Age-matched 52 females who presented to OPD for complain other than breast pathology were included as the"control group". The sociodemographic of both cases and controls and histopathological characteristics of cases were recorded. Serum 25-(OH)2D levels were studied by the ELISA technique and recorded in ng/ml. Vitamin D deficiency was considered at serum level less than 20 ng/ml.RESULTS: Mean age was 40.1 Years for controls and 47.6 Years for cases. Mean height, weight and BMI did not differ between cases and controls. Serum Vitamin D levels were significantly lower in cases (85.7%) than controls (55.8%). The unadjusted and adjusted ORs for breast cancer in cases and controls showed a statistically significantly increased risk of breast cancer with low vitamin D concentration (p value0.003). After adjustment for age, parity, BMI, sun exposure, economic status and education status the ORs (95% CIs) for breast cancer risk was7.8 (1.99 - 30.58) for women with vitamin D concentrations

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17:00

Can Low Doses of Chemicals Affect Your Health? A New Report Weighs the Evidence "IndyWatch Feed Health"

By Rachel Shaffer, University of Washington

Toxicologys founding father, Paracelsus, is famous for proclaiming that the dose makes the poison. This phrase represents a pillar of traditional toxicology: Essentially, chemicals are harmful only at high enough doses.

But increasing evidence suggests that even low levels of endocrine disrupting chemicals can interfere with hormonal signals in the body in potentially harmful ways.

Standard toxicity tests dont always detect the effects that chemicals can have at lower levels. And, even when the data do suggest such effects, scientists and policymakers may not act upon this information in a timely manner.

Recognizing these challenges, the U.S. Environmental Protection Agency (EPA) asked a committee of scientists to study the issue in detail. How can we better identify whether chemicals have effects at low doses? And how can we act on this information to protect public health?

After several years of work, the committees report was released by the National Academy of Sciences in July. This landmark report provides the EPA with a strategy to identify and analyze data about low-dose health effects, as well as two case study examples. It is an evidence-based call to action, and scientists and policymakers should take notice.

...

16:51

Evidence shows a strong association between vitamin D deficiency and increased risk of heart failure in elderly populations. "IndyWatch Feed Health"

PMID:  ESC Heart Fail. 2017 Aug 17. Epub 2017 Aug 17. PMID: 28817241 Abstract Title:  Association between vitamin D deficiency and heart failure risk in the elderly. Abstract:  AIMS: The aim of this study was to evaluate the association between vitamin D deficiency and risk of heart failure in elderly patients of cardiology outpatient clinics.METHODS AND RESULTS: A cross-sectional study with an analytical approach was employed. Clinical data were collected from the elderly from August 2015 to February 2016. The dependent variable was the risk of heart failure; the independent variable was vitamin D deficiency; and intervening factors were age, gender, education, ethnicity, hypertension, diabetes mellitus, hypothyroidism, renal failure, dementia, stroke, dyslipidaemia, depression, smoking, alcoholism, obesity, andropause, and cardiac arrhythmia. To analyse the association between vitamin D deficiency and risk of heart failure, we used the bivariate logistic analysis, followed by analysis through the multivariate logistic regression model. Of the 137 elderly, the study found the following: women (75.9%); overweight (48.2%); obese (30.6%); increase in the index waist/hip (88.3%); dyslipidaemia (94.2%) and hypertension (91.2%); coronary artery disease (35.0%); and 27.7% with cardiac arrhythmia or left ventricular hypertrophy. Sixty-five per cent of the elderly were deficient in vitamin D. The risk of heart failure was significantly associated with vitamin D deficiency [odds ratio (OR): 12.19; 95% confidence interval (CI) = 4.23-35.16; P = 0.000], male gender (OR: 15.32; 95% CI = 3.39-69.20, P = 0.000), obesity (OR: 4.17; 95% CI = 1.36-12.81; P = 0.012), and cardiac arrhythmia (OR: 3.69; 95% CI = 1.23-11.11; P = 0.020).CONCLUSIONS: There was a high prevalence of vitamin D deficiency in the elderly, and the evidence shows a strong association between vitamin D deficiency and increased risk of heart failure in this population.

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16:45

How To Make A Giant Cancer-Killing Salad "IndyWatch Feed Health"

Source: How To Make A Giant Cancer-Killing Salad For more content like this visit REALfarmacy.com.

A few years ago, a young man was diagnosed with stage 3 cancer. He opted out of taking the most common treatment chemotherapy. Instead, he decided to focus on healing himself through his diet. This is his anti-cancer salad recipe.   Back in 2003, Chris Wark, a 26-year-old, was diagnosed with stage 3 colon cancer. []

Source: How To Make A Giant Cancer-Killing Salad Learn more at REALfarmacy.com - Healthy News and Information.

16:39

Mango supplementation modulates gut microbial dysbiosis. "IndyWatch Feed Health"

PMID:  J Nutr. 2016 Aug ;146(8):1483-91. Epub 2016 Jun 29. PMID: 27358411 Abstract Title:  Mango Supplementation Modulates Gut Microbial Dysbiosis and Short-Chain Fatty Acid Production Independent of Body Weight Reduction in C57BL/6 Mice Fed a High-Fat Diet. Abstract:  BACKGROUND: High-fat (HF) diet-induced obesity is associated with changes in the gut microbiota. Fiber and other bioactive compounds in plant-based foods are suggested to prevent gut dysbiosis brought on by HF feeding. Mango is high in fiber and has been reported to have anti-obesogenic, hypoglycemic, and immunomodulatory properties.OBJECTIVES: We investigated the effects of freeze-dried mango pulp combined with an HF diet on the cecal microbial population and its relation to body composition, lipids, glucose parameters, short-chain fatty acid (SCFA) production, and gut inflammatory markers in a mouse model of diet-induced obesity.METHODS: Six-wk-old male C57BL/6 mice were randomly assigned to 1 of 4 dietary treatment groups: control (AIN-93M, 10% fat kcal), HF (60% fat kcal), and HF + 1% or 10% mango (HF+1%M or HF+10%M, wt:wt) for 12 wk. The cecal microbial population was assessed by use of 16S rDNA sequencing. Body composition, plasma glucose and lipids, cecal and fecal SCFAs, and mRNA abundance of inflammatory markers in the ileum and colonic lamina propria were assessed.RESULTS: Compared with the control group, HF feeding significantly reduced (P

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16:36

The Emerging Sperm Count Crisis "IndyWatch Feed Health"

If sperm counts continue declining at the current rate, humans could become extinct.

Analyzing nearly 200 studies, researchers have found that the sperm counts in men across North America, Europe, Australia, and New Zealand have halved in less than forty years. The study found that the decline in mens sperm counts may also be accelerating.

Although the study didnt investigate the potential causes of this sharp decline, prior research has implicated exposures to man-made chemicals, especially endocrine disruptors that are plentiful in many consumer products and the pesticides sprayed on our food.

Weve previously reported the evidence that GMOs could also be culprits in declining sperm counts. In a Russian study on hamsters, scientists observed that consumption of GM soybeans tended to slow their sexual maturation, and completely eliminating their ability to reproduce. This can take several generations to unfold. Another study uncovered similar infertility in third-generation mice that consumed GM corn.

There are natural ways to improve male fertility in addition to protecting oneself from exposure to endocrine disruptors, which can be found in unexpected places, such as dental offices or checkout receipts. Natural medicine specialists can also help with more sophisticated tests as well as the right food, supplements, and exercise. Something as simple as enough Vitamin D can make all the difference in restoring fertility.

 

16:34

Congress May Order the FDA to Help Dying Patients "IndyWatch Feed Health"

An important bill has passed the Senate. It needs our support in the House. Action alert!

Earlier this month, the Trickett Wendler Right to Try Act of 2017 passed the Senate and now moves to the House.

The bill expands access to experimental drugs for terminally ill patients who have exhausted all other treatment options. It also frees drug companies from liability where trial medications are provided.

This is a much-needed reform that ANH-USA has supported for a number of years. As weve pointed out, FDA bureaucrats have thrown roadblocks into the path of patients who desire access to experimental and potentially life-saving drugs. The agencys compassionate use program is marred by a cumbersome application and documentation process, and the agency often delays or blocks approval. It can even revoke permission after it has been grantedand does. 

Patients and their families who desire access to experimental drugs are faced with incredibly difficult life and death decisions. Such decisions should be between a patient and his or her doctor, not with the FDA standing in the way. This legislation deserves our support.

Action Alert! Write to your member of Congress and urge him or her to support the federal Right to Try bill. Please send your message immediately.

16:30

Hey, thats my case study: Another retraction after doctors claim rights to case write-up "IndyWatch Feed Health"

A group of researchers have retracted their 2016 case report about a rare dermatologic disorder in the wake of disputes about authorship and institutional approval. The paper describes a young boy with Jobs Syndrome, in which patients experience painful, itchy and frequently disfiguring skin lesions, along with a constellation of other possible symptoms. The condition []

The post Hey, thats my case study: Another retraction after doctors claim rights to case write-up appeared first on Retraction Watch.

16:25

Statin therapy drives a profound remodelling of the gut microbiota, hepatic gene deregulation and metabolic alterations in mice. "IndyWatch Feed Health"

PMID:  Microbiome. 2017 Aug 9 ;5(1):95. Epub 2017 Aug 9. PMID: 28793934 Abstract Title:  Statin therapy causes gut dysbiosis in mice through a PXR-dependent mechanism. Abstract:  BACKGROUND: Statins are a class of therapeutics used to regulate serum cholesterol and reduce the risk of heart disease. Although statins are highly effective in removing cholesterol from the blood, their consumption has been linked to potential adverse effects in some individuals. The most common events associated with statin intolerance are myopathy and increased risk of developing type 2 diabetes mellitus. However, the pathological mechanism through which statins cause these adverse effects is not well understood.RESULTS: Using a murine model, we describe for the first time profound changes in the microbial composition of the gut following statin treatment. This remodelling affected the diversity and metabolic profile of the gut microbiota and was associated with reduced production of butyrate. Statins altered both the size and composition of the bile acid pool in the intestine, tentatively explaining the observed gut dysbiosis. As also observed in patients, statin-treated mice trended towards increased fasting blood glucose levels and weight gain compared to controls. Statin treatment affected the hepatic expression of genes involved in lipid and glucose metabolism. Using gene knockout mice, we demonstrated that the observed effects were mediated through pregnane X receptor (PXR).CONCLUSION: This study demonstrates that statin therapy drives a profound remodelling of the gut microbiota, hepatic gene deregulation and metabolic alterations in mice through a PXR-dependent mechanism. Since the demonstrated importance of the intestinal microbial community in host health, this work provides new perspectives to help prevent the statin-associated unintended metabolic effects.

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16:11

The gut bacterial composition in patients with T2D was partially different from that in the healthy individuals. "IndyWatch Feed Health"

PMID:  Microb Pathog. 2017 Jul 21. Epub 2017 Jul 21. PMID: 28739439 Abstract Title:  The association of type II diabetes with gut microbiota composition. Abstract:  It is known that type 2 diabetes (T2D) in humans could be linked to the composition of gut microbiota. The aim of this study was to evaluate three faecal bacterial species, including Bacteroides fragilis, Bifidobacterium longum and Faecalibacterium prausnitzii in patients with T2D. This case control study included 18 patients with T2D and 18 matched persons without diabetes. The concentrations of B. fragilis, B. longum and F. prausnitzii were determined by quantitative Real-Time PCR. Quantitative PCR analysis revealed that the gut bacterial composition in patients with T2D was partially different from that in the healthy individuals. Faecalibacterium prausnitzii was significantly lower in patients with T2D (P-value = 0.038). Bacteroides fragilis was under-represented in the microbiota of the group with diabetes, but its difference between two groups was not significant (P-value = 0.38). No difference was observed for B. longum community between the both groups (P-value = 0.99).Characterization of specific species of intestinal microbiota shows some compositional changes in patients with T2D. The results may be valuable for developing strategies to control type 2 diabetes by modifying the intestinal microbiota. Long-term studies with emphasis on other bacterial groups aresuggested to clarify the association of T2D with gut microbiota.

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16:05

Pharma Just Ripped Off Pro-Vaccine Advocates In India "IndyWatch Feed Health"

When it comes to pro-vaccine organizations, it seems sometimes they eat their own. As is the case with India and the pneumonia vaccine, Prevnar 13, who pro-vaccine proponents want to disseminate on a mass level...

The post Pharma Just Ripped Off Pro-Vaccine Advocates In India appeared first on Vaxxter.

15:28

Jury Slams Johnson & Johnson with $417M Verdict over Talc-Cancer Link "IndyWatch Feed Health"

A jury awarded a California woman $417 million on August 21, 2017 after she developed ovarian cancer as a result of using Johnson & Johnson Baby Powder for decades as part of her regular feminine hygiene routine. The award includes $70 million in compensatory damages and $347 million in punitive damages.

Los Angeles resident Eva Echeverria, 63, said she had used Johnson & Johnson Baby Powder since she was 11. She stopped using the product in 2016, after reading about another woman who had also developed ovarian cancer as a result of using the powder.

Hundreds of other cases are currently awaiting trial in California. Thousands of similar cases are progressing through state and federal courts, even as we speak. Juries elsewhere have returned 4 other verdicts against Johnson & Johnson.

Read: Johnson & Johnson Loses Another Talcum Powder-Cancer Lawsuit

The plaintiffs allege Johnson & Johnson ignored studies linking its Johnsons Baby Powder and Shower to Shower products to cancer. [2]

Echeverria was diagnosed with ovarian cancer in 2007. She had a softball-sized tumor removed from one of her ovaries, but she is now at the end of her life and was too sick to attend the trial.

Echeverrias attorney, Mark Robinson, said:

Mrs. Echeverria is dying from this ovarian cancer and she said to me all she wanted to do was to help the other women throughout the whole country who have ovarian cancer for using Johnson & Johnson for 20 and 30 years.

She really didnt want sympathy. She just wanted to get a message out to help these other women. [3]

Robinson added:

Johnson & Johnson had many warning bells over a 30 year period but failed to warn the women who were buying its product.

In her testimony, Echeverria said that if Johnson & Johnson Baby Powder had come with a warning label about the potential for cancer, she would have stopped using it much sooner. [1]

Due to the fact that talcum powder is legally considered a cosmetic, Johnson & Johnson has no legal obligation to include a warning label. As a cosmetic product, talcum powder does not have to undergo a review by the FDA.

Some other talc-based products on the market do carry labels that mention the potential risk of ovarian cancer after frequent application for feminine hygiene. Many women apply talcum powder to their genital area, or on sanitary napkins, to prevent odor and chaffing.

Research into the link between talcum powder and ovarian cance...

14:26

National Park Bottled Water Ban Reversed By Trump Administration "IndyWatch Feed Health"

The news is awash with fire and brimstone warnings about plastic pollution, both on land and at sea. To help battle back against the trillions of pieces of plastic littering the planet, the National Park Service put a policy in place in 2011 encouraging national parks to end the sale of bottled water. It wasnt an outright ban, but 23 out of 417 national parks went on to restrict bottled water sales. In mid-August 2017, the Trump Administration reversed the Obama-era policy.

The policy was rolled back in close consultation with Department of Interior leadership, the International Bottled Water Association (IBWA) said in a statement. [2]

Acting National Park Service Director Michael T. Reynolds said in a statement:

While we will continue to encourage the use of free water bottle filling stations as appropriate, ultimately it should be up to our visitors to decide how best to keep themselves and their families hydrated during a visit to a national park. [1]

The ban surely reduced some of the plastic litter plaguing national parks, but aspects of the policy made little sense. The 23 national parks that stopped selling bottled water continued to sell bottles of sweetened drinks, so the policy basically zeroed in on 1 source of pollution while essentially ignoring other sources, and made it impossible for visitors to those particular parks to purchase a healthy beverage option.

Jill Culora, vice president of IBWA, said:

The rescinded policy was seriously flawed.

The parks that banned the sale of bottled water tried to make up for it by spending millions installing water stations.

The policy was established to reduce waste, Culora said, but people coming to the parks that banned the sale of bottled water were still allowed to buy other less healthy beverages including carbonated soft drinks, sports drinks, teas, milk, beer, and wine that are packaged in much heavier plastic, glass, cans, and cardboard containers.

Visitors were also allowed to carry food wrapped in plastic into the parks. [2]

Read: This is Why We Need to Stop Using Plastic (Infographic)

The bottled water policy encouraged visitors to use water fountains and bring refillable bottles to quench their thirst. The park service says it is discontinuing the policy to give visitors more hydration options.

In a statement, the National Park Service said:

The change in policy comes after a review of the policys aims and...

13:59

One way to boost your unis ranking: Ask faculty to cite each other "IndyWatch Feed Health"

Readers who follow scientific publishing will know the term citation stacking as a profile-boosting technique, weve seen journals ask authors to cite them, and individual scientists work together to cite each other, forming citation cartels. And now, weve seen a university do it. A university in Malaysia has instructed its engineering faculty to cite []

The post One way to boost your unis ranking: Ask faculty to cite each other appeared first on Retraction Watch.

13:27

Hope for MS Sufferers: Resistance Training May Slow Brain Atrophy "IndyWatch Feed Health"

Doctors usually advise people with multiple sclerosis (MS) not to exercise for fear that it could exacerbate the illness, but a recent study out of Denmark suggests that resistance training may slow down the progression of MS by slowing brain atrophy and, in some cases, enhancing brain volume. [1] [2]

More recent studies have shown that physical training can relieve many of the symptoms of MS, including 2 of the most telltale symptoms: fatigue and hindered mobility. [2]

Ulrik Dalgas, the studys lead investigator and an associate professor in the department of public health at Aarhus University, said:

Over the past six years, we have been pursuing the idea that physical training has effects on more than just the symptoms, and this study provides the first indications that physical exercise may protect the nervous system against the disease.

For the past 15 years, we have known that physical exercise does not harm people with multiple sclerosis, but instead often has a positive impact on, for example, their ability to walk, their levels of fatigue, their muscle strength and their aerobic capacity, which has otherwise often deteriorated. But the fact that physical training also seems to have a protective effect on the brain in people with multiple sclerosis is new and important knowledge.

For the study, Dalgas and a team of researchers followed 35 people with MS for 6 months. Half of the group engaged in resistance training, while the other half served as a control group, continuing to live their lives as they always had.

Participants underwent brain scans both before and at the conclusion of the study. Through these tests, the researchers observed that the volunteers who engaged in resistance training including leg presses, knee extensions, and hamstring curls had less brain shrinkage, compared with those in the control group. [3]

Some patients scans even showed an increase in the volume of certain brain regions.

Dalgas explained:

Among persons with multiple sclerosis, the brain shrinks markedly faster than normal. Drugs can counter this development, but we saw a tendency that training further minimizes brain shrinkage in patients already receiving medication. In addition, we saw that several smaller brain areas actually started to grow in response to training. [2]

A larger, more in-depth study is necessary to investigate how resistance training positively affects the brain in people with multiple sclerosis. At the moment, the connection has researchers puzzled. O...

12:02

Gratitude Lists are B.S. Ingratitude Lists Saved me "IndyWatch Feed Health"

In this piece for Good Housekeeping, one woman shares how thinking positive and making gratitude lists worsened her depression, and how acknowledging her pain and trauma through ingratitude lists helped her feel validated and empowered.

Gratitude lists didnt help me one bit. Writing them was a practice that drove me deeper into shame and self-loathing when I was already in a very dark place. Gratitude lists imply that those of us who are in pain are choosing misery and just arent working hard enough and that if we just think happy thoughts well float up above our problems like the kids in Peter Pan.

My ingratitude lists helped me grieve the things that Id lost, missed out on, been cheated out of and all the times life had kicked me straight in the heart. I learned that stuffing down anger and sadness with a stack of gratitude lists doesnt make them go away. Writing down the things that made me miserable and furious didnt make them go away either, but it helped me focus on the things in life that I wanted to change because they caused me suffering over and over again. My ingratitude lists gave me direction, focus and helped me move away from shame and toward acceptance and action. My heart still hurts, but I dont scream at myself for being selfish for being sad anymore.

12:01

We Need to Change the way we Think About Alcoholism "IndyWatch Feed Health"

From Massive: The public generally conceptualizes alcoholism as a biological brain disease and rejects the notion that social and cultural factors may contribute to addiction. However, new research shows that family and social support can greatly reduce an individuals risk for alcoholism.

In some ways, thinking about alcoholism as a purely biological disease was a fantastic and desperately needed change, because it helped ease the image of dysfunction typically associated with alcohol use. But I believe the move to apply modern disease theory to studying an illness like Alcohol Use Disorder was problematic, too: it largely removed the social and cultural components of understanding the illness.

By changing the narrative to its just genetics, or, its a brain disease you cant control, Id argue we stunted important sociological research on Alcohol Use Disorder by silently writing off possible social and cultural attributions to the disease. Even though those lenses can be problematic, I dont think erasing them entirely is helping: researchers have shown that this disease like any other language in the light of modern medical advances does absolutely nothing for erasing the stigma associated with alcoholism and mental illness in general.

Article

12:00

Stat News Runs Incomplete Interview with Robert Kennedy Jr: Read Full Transcript "IndyWatch Feed Health"

By Anne Dachel Below is a link to an interview by Helen Branswell of StatNews with Robert Kennedy, Jr. This interviewer was argumentative and out to discredit Kennedy. The narrow scope of the questions showed that. A legitimate journalist would...

09:16

Contrary To Popular Belief, Dietary Calcium Does Not Prevent Bone Loss "IndyWatch Feed Health"

Dairy products, specifically milk is one of the beverages still aggressively pushed as a health promoting food, especially relating to strong bones. However, Bone Mineral Density (BMD) and rates of bone loss showed no association with dietary calcium intake in men, according to a recent study in British Journal of Nutrition.

09:12

Coke Life Wins Stinky Sulfur Award! "IndyWatch Feed Health"

Shit is backwards. The worst offenders of public crimes are often those who are in the highest positions.  It should be just the opposite.

Therefore, its only fitting that theyre awarded for it, hence my latest Stinky Sulfur Award.

Coke is the latest recipient. Theyre notorious for bullying their way straight to the top. For a guy who loves to bully bullies, its a huge honor for me to bestow this award on them. Their consistence in scamming the public, as youll see in the short history lesson, is unmatched.

Despite the anti-bullying campaigns on campuses around the country, the biggest bully continues its devastation unnoticed. Coke still lurks in almost every backpack and every lunchroom across America.

Its only going to get better for Coke, too. Worse for your kids.

In 2006, The Journal of the American Medical Association (JAMA) published the results of a study on sugary soft drinks. They found that as consumption went up, the average weight of 2 to 5 year olds shot up two-fold, since 1975.  

To translate, that means weight doubled among our toddlers, thanks to Coke. Another study showed that this weight increase would steal 11-20 years from the lifespan of those kids born in the year 2000 (currently 16-17 year olds) the largest reduction in longevity ever recorded.

yawn.

To better position themselves outside of the junk food stereotype, Coke now controls dietary guidelines and even government policy to ensure their success even if it means selling total shit disguised as a healthy indulgence to kids.

As of July 2017, Coke funds the exact same organizations that were built to protect us from their predatory advertising and slick sales. Coca-Colas in house physician Dr. Brenda Fitzgerald was appointed as the new chief of the Centers for Disease Control and Prevention (CDC), which monitors the impact of sugary products and artificial sweeteners on human health.

You can bet your ass consumers wont be warned about Coke products anytime soon. Checkmate Corporate America. Again.

The news was celebrated on Twitter by Coca-Colas former chief health and science officer, Rhona Applebaum, who apparently tweeted, An excellent choice! Shes the same doctor who helped orchestrate the establishment of a nonprofit group known as the Global Energy Balance Network. The members inc...

09:00

Viotren and Other Dietary Supplements for Erectile Dysfunction: Buyer Beware "IndyWatch Feed Health"

Viotren and other dietary supplements are being illegally marketed to treat erectile dysfunction. Some of them work, but only because they are adulterated with prescription drugs like Viagra (at up to 31 times the prescription dose). Using them can be risky.

07:00

How Dentistry Is Poisoning the Next Generation "IndyWatch Feed Health"

By Dr. Mercola

Since you read this newsletter, you probably already know that amalgam dental fillings are 50 percent mercury and that mercury-free filling choices are available.  But not everyone can make that choice. Whether insurance companies refuse to pay for mercury-free fillings or vulnerable children are subjected to it without their parents knowledge, mercury-based amalgam fillings still account for almost half of all fillings in the United States today.   

Mercury Poisons Our Children

Mercury a potent poison is not safe for anyone, but it is especially dangerous for children, whose developing brains are very sensitive to the neurotoxic effects of mercury. That is why it is never a good idea to implant an amalgam filling centimeters from your childs brain.

But as long as dentists use amalgam, no child including those without amalgam fillings is safe from the long reach of its mercury. Why? The environmental reason: Dental amalgam is the largest use of mercury in America today. Amalgams mercury goes into the air we breathe, the ground soil that grows our vegetables, the lakes we fish from, and the community water supply we drink from. Children are still exposed to dental mercury by such everyday activities as:

  • Going to dental offices that use amalgam, which have higher levels of mercury in their air
  • Living or going to school near crematoria, which emit mercury from cremated bodies with amalgam in them
  • Eating fish with high mercury content, some of which comes from amalgam that is released into the environment

This week (August 20 through August 27), I am proud to match your donation dollar for dollar to the champion of the cause of mercury-free dentistry, Consumers for Dental Choice.  Consumers for Dental Choice has a great track record of success. Led by my friend, Charlie Brown, a former state attorney general, this nonprofit group ended the state gag rules which directed silence by dentists about the mercury in silver fillings (a false name if there ever was one). 

Consumers for Dental Choice created and led the world alliance that brought home the bacon at the Minamata Convention on Mercury, imposing a duty on every nation to scale down amalgam use and providing a road map on how to do it. And Consumers for Dental Choice prevailed over the pro-mercury forces to gain a spectacular visit in Europe this year. Here is your chance to keep the momentum going.

...

Flame Retardants Damaging Kids' Brains "IndyWatch Feed Health"

By Dr. Mercola

Flame retardant chemicals are found in everything from furniture and mattresses to electronics and baby toys. Notorious neurotoxins, these widespread chemicals have been linked to serious health risks like infertility, birth defects, neurodevelopmental delays, hormone disruptions, various forms of cancer and reduced IQ scores and behavioral problems in children.

One variety of flame retardants, polybrominated diphenyl ethers (PBDEs), resembles the molecular structure of PCBs, which have been linked to cancer, reproductive problems and impaired fetal brain development.

As 1 in 6 U.S. children now suffers from neurodevelopmental disorders, research into possible environmental culprits is ongoing, and a recent study published in Environmental Health Perspectives revealed PBDEs are likely playing a role in the increasing rates of these disorders. In fact, the researchers concluded, "Preventing developmental exposure to PBDEs could help prevent loss of human intelligence."1

Developmental Exposure to Flame Retardants Reduces IQ

A systematic review and meta-analysis looked into exposures to PBDEs that occurred near conception or during in utero, perinatal or childhood time periods. Children experience greater exposure to chemicals pound-for-pound than adults,2 and though the blood-brain barrier is fully formed at birth, its function may be immature, which may allow greater chemical exposures to reach their developing brains.

Children also have lower levels of some chemical-binding proteins, according to the Environmental Working Group (EWG), which allows more of a chemical to reach their organs, while systems that detoxify and excrete chemicals in adults are not fully developed in the children.

These factors, coupled with the fact that a child will be around for 80 years or more, allowing more than enough time for chemicals to do their damage, signals a major challenge for kids born today. Exposure that occurs in utero may be even more problematic, as EWG reported:

"The pace and complexity of growth and development in the womb are unmatched later in life. Three weeks after conception, an embryo, still only 1/100th the size of a water droplet, has nevertheless grown at such an explosive rate that were it not to slow down, it would be born literally the size of a million Earths.

At no other time in life does a person create so much from so little in so short a time. Indust...

1 Out of 12 Doctors Collecting Bonuses for Pushing Opioids "IndyWatch Feed Health"

By Dr. Mercola

More than 33,000 Americans were killed by opioids in 2015, and nearly half of them involved a prescription for the drugs. Each day, the U.S. Centers for Disease Control and Prevention (CDC) notes, 91 Americans die from an opioid overdose, and the numbers keep rising, nearly quadrupling since 2015.1 Knowing that these drugs carry the serious risk of addiction, abuse and overdose, they should be prescribed sparingly and only for the most severe cases of pain, for which no other options are available.

Instead, they are often prescribed widely to treat milder cases of chronic pain, such as that from osteoarthritis or back pain. "In the past decade, while the death rates for the top leading causes of death such as heart disease and cancer have decreased substantially, the death rate associated with opioid pain medication has increased markedly," the CDC noted. "Sales of opioid pain medication have increased in parallel with opioid-related overdose deaths."

It's shocking that, in the midst of this epidemic of opioid overdose deaths, the pharmaceutical industry would still be making payments to physicians to prescribe more opioid products, but this is precisely what's occurring, according to a study published in the American Journal of Public Health.2

1 in 12 Doctors Being Paid by Drug Companies Marketing Opioids

Using the online Open Payments Program from the Centers for Medicare and Medicaid Services, you can easily search to find out what (if any) payments your doctor has received from the pharmaceutical industry, along with the nature of the payments. The researchers used Open Payments to reveal opioid-related payments to physicians between August 2013 and December 2015.

More than 375,000 non-research opioid-related payments were made to more than 68,000 physicians, totaling more than $46 million. This amounts to 1 in 12 U.S. physicians collecting money from drug companies producing prescription opioids.

The top 1 percent of physicians received nearly 83 percent of the payments, and the drug fentanyl, a synthetic o...

04:35

Jury awards $417M to a single plaintiff in lawsuit linking Johnson & Johnson talcum powder to the womans ovarian cancer "IndyWatch Feed Health"

Today in Los Angeles, a jury ordered Johnson & Johnson to pay $417million to terminally ill Eva Echeverria, of California. In her suit, she alleged that J&J didnt adequately warn about the potential cancer risks associated with talcum powder use and that she developed cancer as a proximate result of the unreasonably dangerous and defective

03:24

Pomegranate juice concentrated powder has favourable protective effects against UVB-induced photoaging through anti-apoptotic effects. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2017 Aug ;14(2):1023-1036. Epub 2017 Jun 16. PMID: 28810554 Abstract Title:  Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice. Abstract:  The present study investigated the anti-aging effects of pomegranate juice concentrated powder (PCP) in hairless mice following 15 weeks of UVB irradiation (three times a week; 0.18 J/cm(2)). Skin moisturizing effects were evaluated through skin water, collagen type I and hyaluronan contents, as well as collagen type I and hyaluronan synthesis-related transcript levels. Wrinkle formation and edema scores (skin weights) were also assessed, along with skin matrix metalloproteinase (MMP)-1, MMP-9 and MMP-13 transcript levels. To determine the anti-inflammatory effects of PCP, myeloperoxidase (MPO) activity, interleukin (IL)-1 and IL-10 contents were observed. Caspase-3 and cleaved poly(ADP-ribose) polymerase (PARP) were used as an apoptotic index in epidermal keratinocytes. To determine the anti-oxidative effects of PCP, nitrotyrosine and 4-hydroxynonenal immunoreactive cells were detected and glutathione (GSH) content, malondialdehyde levels, superoxide anion production, Nox2, and GSH reductase mRNA expression were all measured. The results indicated that skin wrinkles induced by photoaging were significantly reduced by PCP, whereas skin water contents, collagen type I and hyaluronan contents all increased. Furthermore, IL-1 levels in the PCP-treated groups were lower than those in the UVB-exposed control group. UVB-induced GSH depletion was also inhibited by PCP. Taken together, the results of the current study suggest that PCP has favorable protective effects against UVB-induced photoaging through anti-apoptotic effects, MMP activity inhibition and ECM (COL1 and hyaluronan) synthesis-related moisturizing, anti-inflammatory and anti-oxidative effects.

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03:16

Purple sweet potato anthocyanins exhibited beneficial effects on hepatic steatosis. "IndyWatch Feed Health"

PMID:  Appl Physiol Nutr Metab. 2017 Jun 21:1-10. Epub 2017 Jun 21. PMID: 28636830 Abstract Title:  Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBP signalling in high-fat-diet-treated mice. Abstract:  Our previous work showed that purple sweet potato colour (PSPC), a class of naturally occurring anthocyanins, effectively improved hepatic glucose metabolic dysfunction in high-fat-diet (HFD)-treated mice. This study investigated the effects of PSPC on HFD-induced hepatic steatosis and the signalling events associated with these effects. Mice were divided into 4 groups: control group, HFD group, HFD+PSPC group, and PSPC group. PSPC was administered daily for 20 weeks at oral doses of 700 mg/(kgday)(-1)). Our results showed that PSPC significantly improved obesity and related metabolic parameters, as well as liver injury in HFD-treated mice. Moreover, PSPC dramatically attenuated hepatic steatosis in HFD-treated mice. PSPC markedly prevented oxidative stress-mediated Src activation in HFD-treated mouse livers. Furthermore, PSPC feeding remarkably suppressed mitogen-activated protein kinase kinase/extracellular-signal-regulated kinase (MEK/ERK) signalling and consequent CCAAT/enhancer binding protein (C/EBP) activation and restored AMPK activation in HFD-treated mouse livers, which was confirmed by U0126 treatment. Ultimately, PSPC feeding dramatically reduced protein expression of FAS and CD36 and the activation of ACC, and increased the protein expression of CPT1A in the livers of HFD-treated mice, indicating decreased lipogenesis and fatty acid uptake and enhanced fatty acid oxidation. In conclusion, PSPC exhibited beneficial effects on hepatic steatosis, which were associated with blocking Src and C/EBP activation.

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02:43

Purple sweet potato protected against HFD-induced hepatic inflammation by boosting NAD level to inhibit NLRP3 inflammasome activation. "IndyWatch Feed Health"

PMID:  Molecules. 2017 Aug 8 ;22(8). Epub 2017 Aug 8. PMID: 28786950 Abstract Title:  The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice. Abstract:  Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, exhibits beneficial effects on metabolic syndrome. Sustained inflammation plays a crucial role in the pathogenesis of metabolic syndrome. Here we explored the effects of PSPC on high-fat diet (HFD)-induced hepatic inflammation and the mechanisms underlying these effects. Mice were divided into four groups: Control group, HFD group, HFD + PSPC group, and PSPC group. PSPC was administered by daily oral gavage at doses of 700 mg/kg/day for 20 weeks. Nicotinamide riboside (NR) was used to increase NAD levels. Our results showed that PSPC effectively ameliorated obesity and liver injuries in HFD-fed mice. Moreover, PSPC notably blocked hepatic oxidative stress in HFD-treated mice. Furthermore, PSPC dramatically restored NAD level to abate endoplasmic reticulum stress (ER stress) in HFD-treated mouse livers, which was confirmed by NR treatment. Consequently, PSPC remarkably suppressed the nuclear factor-B (NF-B) p65 nuclear translocation and nucleotide oligomerization domain protein1/2 (NOD1/2) signaling in HFD-treated mouse livers. Thereby, PSPC markedly diminished the NLR family,pyrin domain containing 3 (NLRP3) inflammasome activation, ultimately lowering the expressions of inflammation-related genes in HFD-treated mouse livers. In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD level to inhibit NLRP3 inflammasome activation.

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01:58

The robust anticonvulsant effects of CBD may result from multiple pharmacological mechanisms. "IndyWatch Feed Health"

PMID:  Epilepsy Behav. 2017 Aug 15 ;75:29-35. Epub 2017 Aug 15. PMID: 28821005 Abstract Title:  Anticonvulsant effect of cannabidiol in the pentylenetetrazole model: Pharmacological mechanisms, electroencephalographic profile, and brain cytokine levels. Abstract:  Cannabidiol (CBD), the main nonpsychotomimetic compound from Cannabis sativa, inhibits experimental seizures in animal models and alleviates certain types of intractable epilepsies in patients. Its pharmacological profile, however, is still uncertain. Here we tested the hypothesis that CBD anticonvulsant mechanisms are prevented by cannabinoid (CB1 and CB2) and vanilloid (TRPV1) receptor blockers. We also investigated its effects on electroencephalographic (EEG) activity and hippocampal cytokines in the pentylenetetrazole (PTZ) model. Pretreatment with CBD (60mg/kg) attenuated seizures induced by intraperitoneal, subcutaneous, and intravenous PTZ administration in mice. The effects were reversed by CB1, CB2, and TRPV1 selective antagonists (AM251, AM630, and SB366791, respectively). Additionally, CBD delayed seizure sensitization resulting from repeated PTZ administration (kindling). This cannabinoid also prevented PTZ-induced EEG activity and interleukin-6 increase in prefrontal cortex. In conclusion, the robust anticonvulsant effects of CBD may result from multiple pharmacological mechanisms, including facilitation of endocannabinoid signaling and TRPV1 mechanisms. These findings advance our understanding on CBD inhibition of seizures, EEG activity, and cytokine actions, with potential implications for the development of new treatments for certain epileptic syndromes.

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01:43

Parkinsons disease may be induced by spores from fungi or Actinobacteria. "IndyWatch Feed Health"

PMID:  Med Hypotheses. 2017 Jul ;104:48-53. Epub 2017 May 26. PMID: 28673590 Abstract Title:  Parkinson's disease; the hibernating spore hypothesis. Abstract:  The authors support the hypothesis that a causative agent in Parkinson's disease (PD) might be either fungus or bacteria with fungus-like properties - Actinobacteria, and that their spores may serve as 'infectious agents'. Updated research and the epidemiology of PD suggest that the disease might be induced by environmental factor(s), possibly with genetic susceptibility, and that-synuclein probably should be regarded as part of the body's own defense mechanism. To explain the dual-hit theory with stage 1 involvement of the olfactory structures and the 'gut-brain'-axis, the environmental factor is probably airborne and quite 'robust' entering the body via the nose/mouth, then to be swallowed reaching the enteric nervous system with retained pathogenicity. Similar to the essence of smoking food, which is to eradicate microorganisms, a viable agent may be defused by tobacco smoke. Hence, the agent is likely to be a 'living' and not an inert agent. Furthermore, and accordant with the age-dependent incidence of LPD, this implies that a dormant viable agent have been escorted by -synuclein via retrograde axonal transport from the nose and/or GI tract to hibernate in the associated cerebral nuclei. In the brain, PD spreads like a low-grade infection, and that patients develop symptoms in later life, indicate a relatively long incubation time. Importantly, Actinomyces species may form endospores, the hardiest known form of life on Earth. The authors hypothesize that certain spores may not be subject to degradation by macroautophagy, and that these spores become reactivated due to the age-dependent or genetic reduced macroautophagic function. Hence, the hibernating spore hypothesis explains both early-onset and late-onset PD. Evaluation of updated available information are all consistent with the hypothesis that PD may be induced by spores from fungi or Actinobacteria and thus supports Broxmeyer's hypothesis put forward 15years ago.

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01:28

This review aims to explore the influence of the gut microbiota on host neural function and behaviour. "IndyWatch Feed Health"

PMID:  J Anim Sci. 2017 Jul ;95(7):3225-3246. PMID: 28727115 Abstract Title:  The microbiota-gut-brain axis as a key regulator of neural function and the stress response: Implications for human and animal health. Abstract:  The brain-gut-microbiota axis comprises an extensive communication network between the brain, the gut, and the microbiota residing there. Development of a diverse gut microbiota is vital for multiple features of behavior and physiology, as well as many fundamental aspects of brain structure and function. Appropriate early-life assembly of the gut microbiota is also believed to play a role in subsequent emotional and cognitive development. If the composition, diversity, or assembly of the gut microbiota is impaired, this impairment can have a negative impact on host health and lead to disorders such as obesity, diabetes, inflammatory diseases, and even potentially neuropsychiatric illnesses, including anxiety and depression. Therefore, much research effort in recent years has focused on understanding the potential of targeting the intestinal microbiota to prevent and treat such disorders. This review aims to explore the influence of the gut microbiota on host neural function and behavior, particularly those of relevance to stress-related disorders. The involvement of microbiota in diverse neural functions such as myelination, microglia function, neuronal morphology, and blood-brain barrier integrity across the life span, from early life to adolescence to old age, will also be discussed. Nurturing an optimal gut microbiome may also prove beneficial in animal science as a means to manage stressful situations and to increase productivity of farm animals. The implications of these observations are manifold, and researchers are hopeful that this promising body of preclinical work can be successfully translated to the clinic and beyond.

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01:15

The brain-gut axis contributes to neuroprogression in stress-related disorders. "IndyWatch Feed Health"

PMID:  Mod Trends Pharmacopsychiatry. 2017 ;31:152-161. Epub 2017 Jul 24. PMID: 28738330 Abstract Title:  The Brain-Gut Axis Contributes to Neuroprogression in Stress-Related Disorders. Abstract:  There is a growing emphasis on the relationship between the complexity and diversity of the microorganisms that inhabit our gut (human gastrointestinal microbiota) and brain health. The microbiota-gut-brain axis is a dynamic matrix of tissues and organs including the brain, glands, gut, immune cells, and gastrointestinal microbiota that communicate in a complex multidirectional manner to maintain homeostasis. Changes in this environment may contribute to the neuroprogression of stress-related disorders by altering physiological processes including hypothalamic-pituitary-adrenal axis activation, neurotransmitter systems, immune function, and inflammatory responses. While appropriate, coordinated physiological responses, such as immune or stress responses, are necessary for survival, the contribution of repeated or chronic exposure to stress may predispose individuals to a more vulnerable state leaving them more susceptible to stress-related disorders. In this chapter, the involvement of the gastrointestinal microbiota in stress- and immune-mediated modulation of neuroendocrine, immune, and neurotransmitter systems and the consequential behavior is considered. We also focus on the mechanisms by which commensal gut microbiota can regulate neuroinflammation and further aim to exploit our understanding of their role in the effects of the microbiota-gut-brain axis on the neuroprogression of stress-related disorders as a consequence of neuroinflammatory processes.

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00:58

Both depression and T2D are associated with dysregulation of the hypothalamic-pituitary-adrenal and brain-gut-microbiome. "IndyWatch Feed Health"

PMID:  Curr Diab Rep. 2017 Aug 16 ;17(10):90. Epub 2017 Aug 16. PMID: 28815394 Abstract Title:  Shared Dysregulation of Homeostatic Brain-Body Pathways in Depression and Type 2 Diabetes. Abstract:  PURPOSE OF REVIEW: The purpose of this review is to provide an overview of shared dysregulation of the hypothalamic-pituitary-adrenal (HPA) and brain-gut-microbiome (BGM) axes associated with depression and type 2 diabetes (T2D). Clinical implications and future research are also discussed.RECENT FINDINGS: Both depression and T2D are associated with dysregulation of the HPA and BGM axes. These pathways regulate immune function, glucose metabolism, and sleep, which are altered in both illnesses. Dysregulation of homeostatic brain-body pathways may be positively influenced through different therapeutic actions, including psychotherapy, healthy eating, physical activity, sleep promotion, and certain anti-inflammatory or antidepressant medications. While the causal nature of the relationship between depression and T2D remains unclear, these conditions share dysregulation of homeostatic brain-body pathways that are central to mental and physical health. Better understanding of this dysregulation may provide opportunities for interventions that could benefit both conditions. Future research should examine the additive burden of depression and T2D on HPA and BGM dysregulation and better differentiate depression from emotional distress.

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00:41

Back to School Alert: Gifted Children Being Mislabeled ADHD and Given Stimulant Drugs "IndyWatch Feed Health"

Watchdog Group Alerts Parents and Teachers About Gifted Children Being Mislabeled ADHD and Given Stimulant Drugs

By CCHR International

With children returning to school parents and teachers are being alerted to the high number of gifted children that could be falsely diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) and drugged with psychostimulants that may harm their mental performance and creativity.

As part of its Fight for Kids campaign, the mental health watchdog, Citizens Commission on Human Rights International (CCHR) provides research and articles to teachers and parents to increase awareness of such pediatric misdiagnosis.

Its important for parents and teachers to work together to ensure that children are not placed on mind-altering drugs that can crush their enthusiasm, creativity and learning abilities.

Approximately 11 percent of all U.S. children aged 4-17 years are diagnosed with ADHD, according to the Centers for Disease Control and Prevention (CDC).[1]

In high school children alone, the diagnosis has been made in 15 percent.[2]

About 70 percent of children diagnosed with ADHD are prescribed drugs, according to Richard Scheffler, professor of health economics and public policy at the University of California-Berkeley and co-author of the book The ADHD Explosion.[3]

CCHR says the symptoms of this disorder are so subjective that gifted children are being put at risk of being labeled with ADHD and forced onto powerful stimulants that the Drug Enforcement Administration warns are more potent than cocaine.

In an article that has been widely quoted in literature, the symptoms of ADHD were...

00:39

Prioritise groundwater "IndyWatch Feed Health"

Groundwater has been the lifeline for millions across the country. As much as 80% of rural and 50% of the urban population of India depend on groundwater for domestic and irrigation purposes. Karnataka is not an exception. As much as 99% of the state is covered by hard rock aquifer, except in coastal areas where alluvial aquifer dominates. Erratic rainfall, over extraction of groundwater for agriculture and natural and man-made pollution has endangered this precious source of water, prompting urgent need to form strict regulation to protect, preserve, harness and improve the groundwater table.

The water table is rapidly falling in several parts of Karnataka because of over-exploitation of groundwater, mainly for irrigation. The Central Groundwater Board data shows the groundwater in as many as 82 taluks are in either over-exploited, critical or semi-critical stages that means, in several parts of the state, more groundwater is being extracted than it is being recharged by rains. The result is eye-popping: groundwater level across 70% of the state falls rapidly in the post-monsoon season, leaving many of the dug wells dry.

The groundwater problem is being worsened by toxic natural and man-made contaminants. Salinity, chloride, fluoride, iron and arsenic are the predominant natural contaminants in the state. Fluoride, the cause for bone deformities and fluorosis, is found exceeding permissible limits of 1.5mg/litre in the samples collected in 20 districts by Central Groundwater Board. Raichur has the worst fluoride concentration, followed by Kalaburagi and Ballari.

Agriculture not only uses more than 80% of the groundwater extracted but also adds nitrate, phosphate, pesticides and herbicides. As many as 25 districts have nitrate exceeding critical limits of 45 mg/l. Too much nitrate in drinking water poses a risk to infants under six months of age, causing blue baby syndrome. Bacteria which are present in an infants stomach can convert nitrate to nitrite (NO2), a chemical which can interfere with the ability of the infants blood to carry oxygen. No data is available for other more potentially toxic compounds such as pesticides.

Experience in the industrialised world shows that industries are the major sources of contaminants. Various industries manufacturing cars, textiles, polymers, electronics, electroplating, paints, dry-cleaning, glass, chemicals, etc., use a wide range of chemicals in their processes. Many a time, these chemicals are released into the soil because of improper handling, leakage of pipes or underground tanks and accidental spillage, etc. Unfortunately, some industries illegally inject untreated industrial effluents into the groundwater. Even mining an...

00:34

Netherlands going forward with thorium reactor research "IndyWatch Feed Health"

The first phase of a Salt Irradiation Experiment (SALIENT) has begun at the Nuclear Research and Consultancy Group in Petten, a nuclear research facility along the North Sea coast in the Netherlands.

The experiment is being carried out with the cooperation of the European Commission Laboratory Joint Research Center-ITU (JRC) in Karlsruhe, Germany with the initial aim of producing cleaner reactor fuel. The researchers will later look into materials for reactor construction.

It has been 45 years since this type of experiment has been undertaken. The last research into Molten-Salt thorium reactors was carried out in the 1960s at the Oak Ridge National Laboratory (ORNL) in the United States. The ORNLs Molten-Salt Reactor Experiment (MSRE) was constructed in 1964, went critical in 1965 and was in operation until 1969.

First Stage of Experiment

Scientists at the Petten facility will use the high-flux reactor, one of two reactors on-site, under the management of Sander DeGroot and lead scientist Ralph Hania.

The team will be melting a sample of thorium salt fuel a mixture of lithium fluoride and thorium fluoride inside an insulated graphite crucible.

Inside the crucible, neutron bombardment will trigger a nuclear reaction that changes the thorium salts into uranium isotopes that will undergo a nuclear reaction. The purpose of this part of the experiment will be to remove whats called noble metals, those metals that are not involved in a nuclear reaction.

To find the most efficient fuel production, two processes will be used. To test this, the scientists will place nickel foil in one crucible and a cube of highly porous nickel in another crucible, in both cases, hoping the noble metals will preferentially precipitate out onto the nickel. This part of the experiment is crucial in that the tests will determine the path of the next phase of the research project.

The use of an insulated graphite crucible in the Petten experiment is important because it tells us just how far we have come in the development of a graphite material. ORNL scientists wanted to use graphite in the 1960s, knowing the thorium salt would not permeate graphite in which the pores were on the order of a micrometer.

But they only had a few small experimental pieces. Difficulties were encountered when a manufac...

00:32

The demethylation of Foxp3 promoter might be involved in the effectiveness of B. Longum treatment for IBD. "IndyWatch Feed Health"

PMID:  Microb Pathog. 2017 Jul 18 ;110:426-430. Epub 2017 Jul 18. PMID: 28733028 Abstract Title:  Bifidobacterium longum affects the methylation level of forkhead box P3 promoter in 2, 4, 6-trinitrobenzenesulphonic acid induced colitis in rats. Abstract:  Bifidobacterium longum (B. Longum) is a common probiotic colonized in the human gut and against the development of chronic inflammation including inflammatory bowel disease (IBD). But the underlying mechanism remains unknown. The aim of this study was to evaluate the affection of B. longum on the methylation levels of forkhead box P3 (Foxp3) promoter. 2, 4, 6-trinitrobenzenesulphonic acid (TNBS)-induced colitis rat models were treated with B. longum or medium, respectively. The genomic DNA of spleen peripheral blood mononuclear cells (PBMC) cells was extracted. After bisulphite treatment and pyrosequencing, the methylation levels of each CpG sites in the promoter of forkhead box protein P3 (Foxp3) were analyzed. B. Longum treatment changes the methylation level in Foxp3 promoter in TNBS-treated colitis rats, and significantly demethylates several CpG sites in Foxp3 promoter. The demethylation of Foxp3 promoter might be involved in the effectiveness of B. Longum treatment for IBD. Further research remains necessary to investigate the role of B. Longum in Foxp3 demethylation. Using B. Longum or its metabolic products is an option for further investigations on potential treatments for IBD.

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00:22

B. longum ATCC 15707 has a function in repressing the infectious disease caused by C. difficile 027. "IndyWatch Feed Health"

PMID:  Korean J Food Sci Anim Resour. 2017 ;37(3):368-375. Epub 2017 Jun 30. PMID: 28747822 Abstract Title:  Beneficial Effect of Bifidobacterium longum ATCC 15707 on Survival Rate of Clostridium difficile Infection in Mice. Abstract:  Clostridium difficile infection (CDI) is the main cause of hospital-acquired diarrhea that can cause colitis or even death. The medical-treatment cost and deaths caused by CDI are increasing annually worldwide. New approaches for prevention and treatment of these infections are needed, such as the use of probiotics. Probiotics, including Bifidobacterium spp. and Lactobacillus, are microorganisms that confer a health benefit to the host when administered in adequate amounts. The effect of Bifidobacterium longum ATCC 15707 on infectious disease caused by C. difficile 027 was investigated in a mouse model. The survival rates for mice given the pathogen alone, and with live cells, or dead cells of B. longum were 40, 70, and 60%, respectively. In addition, the intestinal tissues of the B. longum-treated group maintained structural integrity with some degree of damage. These findings suggested that B. longum ATCC 15707 has a function in repressing the infectious disease caused by C. difficile 027.

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00:19

Conference: Only Two Days Left to Save Big "IndyWatch Feed Health"

The 6th Citizens Conference on Fluoride is less than a month away. We urge everyone fighting fluoridation to take advantage of this rare opportunity for concerned citizens, public health experts, and campaigners to learn, network, and take action.  The conference will take place at:

Hyatt Regency Hotel, Crystal City, Virginia
on September 1618, 2017

The hotel is very close to the Washington DCA airport where there is a free hotel shuttle bus and just a few quick metro (subway) stops from Union Station in Washington, D.C. see more in the Overview below.

For those that have already signed up, see below for the news on the Auction we will hold on Saturday night.

For those who havent yet registered for the conference: Please know that most of us are fighting fluoridation in our own communities and collectively we have learned how tough that battle is. When one is accused by their local Public Health department (or local newspaper or local dental association) of being unscientific (or worse) because they object to the fluoridation of their drinking water, it is too easy for people to become intimidated. However, for those of us who have studied the scientific literature on this issue for over 20 years it is clear that the science is on our side. This conference it will make that very clear.

If you are currently involved in a campaign to end fluoridation, or are planning on initiating a campaign in the near future, this conference is for YOU!  We are strongly urging organized fluoride-free groups to pool your resources and send at least one member to the conference next month.  The information and network of support you or a member of your team brings back to the group after the conference will improve your entire campaigns chances of success.

You will be exposed to honest science presented clearly in a language that ordinary citizens can understand and use. You will hear from individuals on how they stopped fluoridation in their communities, and more. See the Agenda below.

BOOKING YOUR HOTEL ROOM: August 23 is the LAST DAY that discounted room rates will be available. Please take advantage of them. See the link below to make reservations.

REGISTRATION FEE. You can pay online using our secure server, or by check. See link below.

REGISTRATION FORM.......

00:07

CNN: Diplomats hit by large sonic attacks causing nausea, headaches, hearing loss "IndyWatch Feed Health"

Senior government officials are reporting that the number of U.S. and Canadian diplomats and their families attacked by a sonic weapon in Havana, Cuba is much larger than initially thought. More than 10 U.S. diplomats and family members received treatment after the months of harassing attacks, which began in mid-November 2016 and stopped this spring. Some

00:06

Probiotics have been shown to alter brain activity as monitored by functional MRI. "IndyWatch Feed Health"

PMID:  Psychosom Med. 2017 Aug 11. Epub 2017 Aug 11. PMID: 28806201 Abstract Title:  Brain-gut-microbiota axis and mental health. Abstract:  OBJECTIVE: The brain-gut-microbiota axis has been put forward as a new paradigm in neuroscience, which may be of relevance to mental illness. The mechanisms of signal transmission in the brain-gut-microbiota axis are complex and involve bidirectional communications which enables gut microbes to communicate with the brain, and the brain to communicate with the microbes. This review assesses the potential usefulness and limitations of the paradigm.METHODS: A selective literature review was conducted to evaluate the current knowledge in clinical and pre-clinical brain-gut-microbiota interactions as related to psychiatric disorders.RESULTS: The overwhelming majority of published studies in the field are preclinical and there is so far a lack of clinical studies. Preliminary studies in psychiatric populations, support the view of a dysbiosis in some conditions, but studies are often small-scale and marred by potential confounding variables. Preclinical studies support the view that psychobiotics ('bacteria which when ingested in adequate amounts have a positive mental health benefit') might be of use in treating some patients with mental health difficulties. To date we have no well conducted studies in clinical populations, though there are some studies in healthy volunteers. A cocktail of probiotics has been shown to alter brain activity as monitored by functional MRI and Bifidobacterium longum was reported to alter brain electrical activity.CONCLUSION: It has yet to be convincingly demonstrated that the exciting findings of psychobiotic efficacy demonstrated in preclinical models of psychiatric illness will translate to patients.

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Monday, 21 August

23:53

A probiotic formula containing Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 reduced the duration of rotavirus diarrhea. "IndyWatch Feed Health"

PMID:  Nutrients. 2017 Aug 16 ;9(8). Epub 2017 Aug 16. PMID: 28813007 Abstract Title:  The Efficacy of Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 Probiotic Treatment in Infants with Rotavirus Infection. Abstract:  A total of 57 infants hospitalized with rotavirus disease were included in this study. The children were randomly divided into the study's two treatment groups: three days of the oral administration of (i) a probiotics formula containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 (N = 28); or (ii) a placebo (probiotic-free skim milk, N = 29) and the standard therapy for diarrhea. There were no differences in age, sex, or blood characteristics between the two groups. When the 57 cases completed the protocol, the duration of the patients' diarrhea was significantly shorter in the probiotics group (4.38 1.29, N = 28) than the placebo group (5.61 1.23, N = 29), with a p-value of 0.001. Symptoms such as duration of fever (p = 0.119), frequency of diarrhea (p = 0.119), and frequency of vomiting (p = 0.331) tended to be ameliorated by the probiotic treatment; however, differences were not statistically significant between the two groups. There were no serious, adverse events and no differences in the frequency of adverse events in both groups.

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23:36

Probiotics decreased the mean duration per crying episode significantly more than a lactase dietary supplement in infants with colic. "IndyWatch Feed Health"

PMID:  J Comp Eff Res. 2017 Mar ;6(2):137-144. Epub 2017 Jan 24. PMID: 28114795 Abstract Title:  Efficacy and safety of APT198K for the treatment of infantile colic: a pilot study. Abstract:  AIM: Comparing efficacy and safety of APT198K (xyloglucan plus heat-killed Lactobacillus reuteri SGL01 and Bifidobacterium brevis SGB01) versus a lactase dietary supplement as first-line treatment of infantile colic.METHODS: Randomized, multicenter, open-label, parallel group, active-controlled study, in 46 infants aged 3-16 weeks with infantile colic, receiving APT198K or a lactase dietary supplement for 10 days.RESULTS: Number and duration of crying episodes decreased significantly versus baseline in both groups. On day 8, the mean duration of crying per episode was significantly shorter in the APT198K group compared with the lactase group (9.14 5.34 vs 13.22 5.29 min; p = 0.014) and remained so up to day 11.CONCLUSION: APT198K decreased the mean duration per crying episode significantly more than a lactase dietary supplement in infants with colic. Further evaluation in larger studies is warranted. Clinical trial registry: EudraCT number 2014-002860-334; https://eudract.ema.europa.eu .

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23:22

Heat-killed L. brevis SBC8803 is safe and is suggested to be effective at improving skin hydration conditions. "IndyWatch Feed Health"

PMID:  Exp Ther Med. 2016 Dec ;12(6):3863-3872. Epub 2016 Nov 2. PMID: 28105118 Abstract Title:  Effects of oral intake of heat-killed Lactobacillus brevis SBC8803 (SBL88) on dry skin conditions: A randomized, double-blind, placebo-controlled study. Abstract:  Lactobacilli are important in intestinal homeostasis, which involves the regulation of immune function, digestive health, cholesterol absorption and intestinal tumor growth amongst others. Our previous investigations have suggested that oral intake of heat-killed Lactobacillus brevis (L. brevis) SBC8803 (SBL88) suppresses dermatitis by modulating the immune function in an atopic dermatitis mouse model. The aim of the present study was to investigate the effect of heat-killed L. brevis SBC8803 intake on skin hydration conditions in humans. A randomized, double-blind, placebo-controlled study was conducted with volunteers with slightly higher levels of transepidermal water loss (TEWL) on the forearm. The subjects (126 people aged between 21 and 59 years) were randomly allocated to three groups so that the level of TEWL and the age were distributed equally among the groups. The subjects took placebo or heat-killed L. brevis SBC8803 at a daily dose of 25 or 50 mg for 12 weeks. Following the exclusion of eight subjects for plausible reasons (two withdrawals from the study, two for study violations, one for not meeting exclusion criteria and three due to their physical condition), 118 subjects were subjected to the analysis. The results of the present study revealed that following the analysis of the whole populations, marginal differences were observed in TEWL (for example, suppression of skin water loss) at the neck in the 25 mg/day group at week 8 and at the lower eye region in the 50 mg/day group at week 4 (P=0.05 and 0.09, respectively, compared with the placebo group analyzed by Dunnett's test). A significant increase in corneal hydration was also observed at the neck in the 25 mg/day group at week 12 (P=0.06, as compared with the placebo group as analyzed by Dunnett's test). In the analysis of the subpopulations whose habitual frequency of taking lactic fermentation products was less than once per week, the levels of corneal hydration at the neck (in the 50 mg/day group) and lower eye region (in the 25 mg/day group) were significantly increased at week 12 (P

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22:53

Fermented milk containing L. rhamnosus SD11 may have beneficial effects on oral health by reducing salivary levels of mutans streptococci. "IndyWatch Feed Health"

PMID:  J Dairy Sci. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28803012 Abstract Title:  Effect of fermented milk containing Lactobacillus rhamnosus SD11 on oral microbiota of healthy volunteers: A randomized clinical trial. Abstract:  The aims of this study were to evaluate whether short-term consumption of fermented milk containing Lactobacillus rhamnosus SD11 affected levels of oral microbiota in vivo and whether L. rhamnosus SD11 could colonize in the human mouth. We also monitored for potential side effects of the probiotic. The applicability of using L. rhamnosus SD11 compared with Lactobacillus bulgaricus as a starter culture for fermented milk was evaluated. After informed consent, 43 healthy young adults were recruited and randomly assigned to either the probiotic or control group and received fermented milk containing L. rhamnosus SD11 or L. bulgaricus, respectively, once daily for 4 wk. The numbers of mutans streptococci, lactobacilli, and total bacteria in saliva were counted at baseline and then after 4 and 8 wk. An oral examination was performed at baseline and after 8 wk. The persistence of L. rhamnosus SD11 was investigated by DNA fingerprinting using arbitrary primer-PCR. Results demonstrated that statistically significant reductions in mutans streptococci and total bacteria were observed in the probiotic group compared with the control group, and the number of lactobacilli was significantly increased in both groups after receiving fermented milks. Lactobacillus rhamnosus SD11 could be detected (in>80% of subjects) up to 4 wk following cessation of dosing among subjects in the probiotic group. No side effects were reported. Thus, L. rhamnosus SD11 could be used as a starter culture for fermented milk. Daily consumption of L. rhamnosus SD11-containing fermented milk for 4 wk may have beneficial effects on oral health by reducing salivary levels of mutans streptococci. The probiotic was apparently able to colonize the oral cavity for a longer time than previously reported. However, the potential benefits of probiotic L. rhamnosus SD11 on oral health require further evaluation with a larger group of volunteers in a longer-term study.

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22:46

Lactobacillus probiotics could be useful in obesity treatments or prevention. "IndyWatch Feed Health"

PMID:  Int J Obes (Lond). 2017 Jul 10. Epub 2017 Jul 10. PMID: 28792488 Abstract Title:  Effect of Lactobacillus on body weight and body fat in overweight subjects: a systematic review of randomized controlled clinical trials. Abstract:  Gut microbiota is important for maintaining body weight. Modulation of gut microbiota by probiotics may result in weight loss and thus help in obesity treatment. The aim of this systematic review was to evaluate the effects of Lactobacillus on weight loss and/or fat mass in overweight adults. A search was performed on the Medline (PubMed) and Scopus electronic databases using the search terms: 'probiotics', 'Lactobacillus, 'obesity', 'body weight changes', 'weight loss', 'overweight', 'abdominal obesity', 'body composition', 'body weight', 'body fat' and 'fat mass'. In the total were found 1567 articles, but only 14 were included in this systematic review. Of these nine showed decreased body weight and/or body fat, three did not find effect and two showed weight gain. Results suggest that the beneficial effects are strain dependent. It can highlight that Lactobacillus plantarum and Lactobacillus rhamnosus when combined with a hypocaloric diet, L. plantarum with Lactobacillus curvatus, Lactobacillus gasseri, Lactobacillus amylovorus, Lactobacillus acidophilus and Lactobacillus casei with phenolic compounds, and multiple species of Lactobacillus.International Journal of Obesity advance online publication, 8 August 2017; doi:10.1038/ijo.2017.161.

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22:38

How to Spot High Quality Olive Oil On a Shelf Full of Fake Brands "IndyWatch Feed Health"

This article is shared with permission from our friends at Be Well, by Dr. Frank Lipman. We all know that extra-virgin olive oil is good for us. The delicious staple of the Mediterranean diet is loaded with healthy fats that help reduce our risk of chronic diseases a big reason...

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The post How to Spot High Quality Olive Oil On a Shelf Full of Fake Brands appeared first on Healthy Holistic Living.

22:02

The anti-inflammatory activity of orally administered L. plantarum No.14 and L. rhamnosus GG is mediated, at least in part, by circulating exosomes. "IndyWatch Feed Health"

PMID:  Biochem Biophys Res Commun. 2017 Jul 22 ;489(2):248-254. Epub 2017 May 27. PMID: 28559134 Abstract Title:  Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro. Abstract:  Orally administered Lactobacillus strains, including L. plantarum No.14 and L. rhamnosus GG, reportedly reduce inflammatory cytokine production in mice. The present study tested our idea that circulating exosomes mediate the action of Lactobacillus strains. The lipopolysaccharide-induced production of TNF- and IL-6 in vitro was attenuated in peritoneal exudate cells (PECs) isolated from C57BL/6N mice that had been fed L. plantarum No.14. When PECs were cultured for 24 h with exosomes isolated from the serum of mice fed L. plantarum No.14 or L. rhamnosus GG, accumulation of both TNF- and of the corresponding mRNA was lowered. Growth in the presence of these exosomes also decreased the production of TNF- and IL-6 by the murine macrophage cell line RAW264.7. In contrast, supplementation with exosome-depleted serum of mice fed L. plantarum No.14 or L. rhamnosus GG failed to affect the production of TNF- and IL-6 by RAW264.7 cells. When PECs and RAW264.7 cells were cultured for 24 h with PKH67-labeled exosomes isolated from murine serum, fluorescent signal was observed inside the cells, suggesting that these cells incorporate serum exosomes. We propose that the anti-inflammatory activity of orally administered L. plantarum No.14 and L. rhamnosus GG is mediated, at least in part, by circulating exosomes.

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21:43

Is This What You Want Outside Your Bedroom Window? "IndyWatch Feed Health"

By Catherine J. Frompovich

5G is creating an environmental nightmare in more ways than technology addicts even can imagine!

Since 5G waves dont travel very far, innovative cell towers of all shapes, types and sizesincluding that of a refrigerator sizemost likely will be planted on a pole of some sort outside most buildings, including your home!

5G cell towers are noisy suckers, too, as they contain fans to keep them cool! Another fire hazard like AMI Smart Meters? Just imagine whirl, whirl, whirl all night long outside your bedroom window sending EMF radiation along with that constant droning noise! And you cant stop it!

[1]

According to San Francisco, California, City Planner Omar Masry, a large cabinet the size of a refrigerator, with noisy cooling fans for the computers, may be mounted a few feet from a bedroom bay window in a dense area of town. Can you imagine sleeping every night with that noise and electrosmog pollution?

...

21:29

Mother Blamed for Babys Vaccine Injuries Baby Adopted Out as Parents Face Jail "IndyWatch Feed Health"

Rebecca%20with%20Javoni

Rebecca and her son Javoni. Photo provided by the family.

by Health Impact News/MedicalKidnap.com Staff

In December 2013, in the State of Florida, Ms. Rebecca Wood gave birth to Javoni, a seven-pound baby boy with mild infant jaundice. Doctors assured her that jaundice was relatively common in newborns and told her that he would recover from the condition in a few days.

Although his health initially improved, his health deteriorated significantly within hours of receiving a series of routine vaccinations just eight weeks later. Rebecca explained:

Immediately after his two-month routine vaccinations, my son became very ill. He had constant diarrhea. Diarrhea after vaccinations is not uncommon; however, his diarrhea continued for days.

We took him to the emergency room, concerned since his diarrhea had not stopped. They transferred him to the Tallahassee Memorial Hospital due to elevated temperature and ultimately he was admitted. They did various blood tests and gave him antibiotics. The diarrhea continued.

He was released from the hospital after three nights with antibiotics. We followed up with his pediatricians office because we were still concerned that the diarrhea had not stopped. He also was not gaining any weight. The doctors did not appear to be very concerned.

One evening, Javoni was coughing non-stop. I called the after-hours nurse and they advised that he sleep in his bouncer. He started spitting up more than normal. Once again, [we took] a trip to the pediatrician and their solution was to provide him with Zantac for possible acid reflux.

The vaccinations that Javoni received were the following:

  • DTaP (diphtheria, tetanus, pertussis)
  • IPV (inactivated polio)
  • HIB (haemophilus influenzae type B)
  • PVC 13 (pneumococcal conjugate vaccine)
  • ...

21:29

Mother Blamed for Babys Vaccine Injuries Baby Adopted Out as Parents Face Jail "IndyWatch Feed Health"

Rebecca%20with%20Javoni

Rebecca and her son Javoni. Photo provided by the family.

by Health Impact News/MedicalKidnap.com Staff

In December 2013, in the State of Florida, Ms. Rebecca Wood gave birth to Javoni, a seven-pound baby boy with mild infant jaundice. Doctors assured her that jaundice was relatively common in newborns and told her that he would recover from the condition in a few days.

Although his health initially improved, his health deteriorated significantly within hours of receiving a series of routine vaccinations just eight weeks later. Rebecca explained:

Immediately after his two-month routine vaccinations, my son became very ill. He had constant diarrhea. Diarrhea after vaccinations is not uncommon; however, his diarrhea continued for days.

We took him to the emergency room, concerned since his diarrhea had not stopped. They transferred him to the Tallahassee Memorial Hospital due to elevated temperature and ultimately he was admitted. They did various blood tests and gave him antibiotics. The diarrhea continued.

He was released from the hospital after three nights with antibiotics. We followed up with his pediatricians office because we were still concerned that the diarrhea had not stopped. He also was not gaining any weight. The doctors did not appear to be very concerned.

One evening, Javoni was coughing non-stop. I called the after-hours nurse and they advised that he sleep in his bouncer. He started spitting up more than normal. Once again, [we took] a trip to the pediatrician and their solution was to provide him with Zantac for possible acid reflux.

The vaccinations that Javoni received were the following:

  • DTaP (diphtheria, tetanus, pertussis)
  • IPV (inactivated polio)
  • HIB (haemophilus influenzae type B)
  • PVC 13 (pneumococcal conjugate vaccine)
  • ...

21:19

Energy company shutting off power of residents opposed to smart meters "IndyWatch Feed Health"

If you live in Michigan and have been holding out getting a smart meter, you may soon have your power shut off. DTE has consistently maintained that no one should be worried about the radio frequencies the meters emit (others argue they are harmful to human health and are especially distressing for people with electromagnetic hypersensitivity)

21:07

L. salivarius LI01 and P. pentosaceus LI05 attenuated liver fibrosis by protecting the intestinal barrier and promoting microbiome health. "IndyWatch Feed Health"

PMID:  Sci Rep. 2017 Jul 31 ;7(1):6927. Epub 2017 Jul 31. PMID: 28761060 Abstract Title:  Administration of Lactobacillus salivarius LI01 or Pediococcus pentosaceus LI05 prevents CCl4-induced liver cirrhosis by protecting the intestinal barrier in rats. Abstract:  Alterations in the gut microbiome have been reported in liver cirrhosis, and probiotic interventions are considered a potential treatment strategy. This study aimed to evaluate the effects and mechanisms of Lactobacillus salivarius LI01, Pediococcus pentosaceus LI05, Lactobacillus rhamnosus GG, Clostridium butyricum MIYAIRI and Bacillus licheniformis Zhengchangsheng on CCl4-induced cirrhotic rats. Only administration of LI01 or LI05 prevented liver fibrosis and down-regulated the hepatic expression of profibrogenic genes. Serum endotoxins, bacterial translocations (BTs), and destruction of intestinal mucosal ultrastructure were reduced in rats treated with LI01 or LI05, indicating maintenance of the gut barrier as a mechanism; this was further confirmed by the reduction of not only hepatic inflammatory cytokines, such as TNF-, IL-6, and IL-17A, but also hepatic TLR2, TLR4, TLR5 and TLR9. Metagenomic sequencing of 16S rRNA gene showed an increase in potential beneficial bacteria, such as Elusimicrobium and Prevotella, and a decrease in pathogenic bacteria, such as Escherichia. These alterations in gut microbiome were correlated with profibrogenic genes, gut barrier markers and inflammatory cytokines. In conclusion, L. salivarius LI01 and P. pentosaceus LI05 attenuated liver fibrosis by protecting the intestinal barrier and promoting microbiome health. These results suggest novel strategies for the prevention of liver cirrhosis.

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21:05

Gardasil safety and efficacy debunking the HPV vaccine myths "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

There was an article published in Pediatrics that described how educating either teenagers or their parents about HPV vaccinations had little effect on the overall vaccination rate for the vaccine. Essentially, the researchers found that it was a 50:50 probability that any teen would get the vaccine, regardless of their knowledge of HPV and the vaccine itself.

Skeptical Raptor

21:01

Mother Blamed for Babys Vaccine Injuries Baby Adopted Out as Parents Face Jail "IndyWatch Feed Health"

Rebecca%20with%20Javoni

Rebecca and her son Javoni. Photo provided by the family.

by Health Impact News/MedicalKidnap.com Staff

In December 2013, in the State of Florida, Ms. Rebecca Wood gave birth to Javoni, a seven-pound baby boy with mild infant jaundice. Doctors assured her that jaundice was relatively common in newborns and told her that he would recover from the condition in a few days.

Although his health initially improved, his health deteriorated significantly within hours of receiving a series of routine vaccinations just eight weeks later. Rebecca explained:

Immediately after his two-month routine vaccinations, my son became very ill. He had constant diarrhea. Diarrhea after vaccinations is not uncommon; however, his diarrhea continued for days.

We took him to the emergency room, concerned since his diarrhea had not stopped. They transferred him to the Tallahassee Memorial Hospital due to elevated temperature and ultimately he was admitted. They did various blood tests and gave him antibiotics. The diarrhea continued.

He was released from the hospital after three nights with antibiotics. We followed up with his pediatricians office because we were still concerned that the diarrhea had not stopped. He also was not gaining any weight. The doctors did not appear to be very concerned.

One evening, Javoni was coughing non-stop. I called the after-hours nurse and they advised that he sleep in his bouncer. He started spitting up more than normal. Once again, [we took] a trip to the pediatrician and their solution was to provide him with Zantac for possible acid reflux.

The vaccinations that Javoni received were the following:

  • DTaP (diphtheria, tetanus, pertussis)
  • IPV (inactivated polio)
  • HIB (haemophilus influenzae type B)
  • PVC 13 (pneumococcal conjugate vaccine)
  • ...

20:53

Dorit Rubinstein Reiss an index of contributions to this website "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Dorit Rubinstein Reiss  Professor of Law at the University of California Hastings College of the Law (San Francisco, CA) is a frequent contributor to this and many other blogs, providing in-depth, and intellectually stimulating, articles about vaccines (generally, but sometimes moving to other areas of medicine), social policy and the law. Her articles usually unwind the complexities

Skeptical Raptor

20:51

Oral administration of Lactobacillus rhamnosus GG ameliorates salmonella infantis-induced inflammation. "IndyWatch Feed Health"

PMID:  Front Cell Infect Microbiol. 2017 ;7:323. Epub 2017 Jul 18. PMID: 28770173 Abstract Title:  Oral Administration of Lactobacillus rhamnosus GG Ameliorates Salmonella Infantis-Induced Inflammation in a Pig Model via Activation of the IL-22BP/IL-22/STAT3 Pathway. Abstract:  The high rate of Salmonella enterica serovar Infantis (S. Infantis) infection poses significant risk for the development of non-typhoidal Salmonella gastroenteritis. However, efficient strategies to prevent or treat the infection remain elusive. Here, we explored the effect of the probiotic Lactobacillus rhamnosus GG (LGG) administration in preventing S. Infantis infection in a pig model. Probiotic LGG (1.0 10(10) CFU/day) was orally administered to newly weaned piglets for 1 week before S. Infantis challenge. LGG pretreatment reduced the severity of diarrhea and alleviated intestinal inflammation caused by S. Infantis. Pre-administration of LGG excluded Salmonella from colonization of the jejunal mucosa but increased the abundance of Bifidobacterium in the feces. LGG promoted the expansion of CD4(+) T-bet(+) IFN(+) T cells but attenuated S. Infantis-induced increases in the percentage of CD4(+) IFN(+) T cells and serum interleukin (IL)-22 levels in peripheral blood after S. Infantis challenge. In the small intestine, LGG pretreatment upregulated expression of the transcription factor T-bet but downregulated the S. Infantis-induced increase of CD4(+) IFN(+) T cells in Peyer's patches and IL-7R expression in the jejunum. Notably, LGG-treated pigs had enhanced expression of IL-22 and activated STAT3 in the ileum in response to S. Infantis infection. Pretreatment of pigs with LGG also elevated intestinal IL-22-binding protein production in response to S. Infantis challenge. In contrast, LGG consumption reduced the S. Infantis-induced increase in the number of CCL20-expressingcells in the jejunum. Our results suggest that the mechanism by which LGG ameliorates the intestinal inflammation caused by S. Infantis involves the upregulation of T-bet, activation of STAT3, and downregulation of CCL20.

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19:56

Saffron Healing Powers Confirmed by Science "IndyWatch Feed Health"

Saffron: Ancient Healing Powers Confirmed by Science

Posted on: Friday, April 13th 2012 at 7:45 pm
Written By: Sayer Ji, Founder
This article is copyrighted by GreenMedInfo LLC, 2013

Clearly there is something magical about the Crocus sativus flower, from which the spice saffron is derived.  If its striking beauty does not immediately cast a spell on its beholder, often it simply takes experiencing the spice to fall into full enchantment with it.  While saffron is exceptionally expensive, because it takes approximately 150 flowers to yield just 1,000 mg (0.035 oz) of dry saffron threads, and costs approximately $1,000 a pound, it does not take much to have an effect. Its uniqueness is also illustrated by the fact that it shuns mechanization, requiring of its would-be possessors that it be painstakingly harvested by hand , as no doubt has been done for tens of thousands, if not hundreds of thousands of years. Because each Crocus sativus flower bears no more than four flowers, each with three vivid crimson stigmas from which the spice is derived, at most only 12 stigma are produced by each, which yields the equivalent of 30 mg (0.011 oz) of fresh saffron or 7 mg (0.00025 oz) dried.  

Saffron has been documented to have been used as a versatile medicine since ancient times. In 2004 researchers studying 3,500 year old frescoes at Thera, a Greek island in the Aegean, found depictions of a goddess presiding over the manufacturer and use of a drug from the saffron flower. [i]   Perhaps even more amazing is the fact that 50,000 year-old depictions of prehistoric places in northwest Iran contained saffron-based pigments, indicating the human relationship with saffron is as old as time itself.[ii]

A Minoan goddess supervising saffron use
Saffron's chemistry expresses otherworldly complexity. It contains over 150 volatile and aroma-yielding compounds a biochemical symphony that ensures its mystery will never fully be plumbed, at least insofar as it great medicinal power remains refractory to the reductionist gaze of modern pharmacology. What power might that be?
...

19:54

Gotu Kola A dozen Proven Medical Benefits "IndyWatch Feed Health"

Gotu Kola: A Dozen Proven Medical Benefits

Posted on: Saturday, August 19th 2017 at 7:30 am

Gotu kola is an ancient plant medicine used for thousands of years for a number of disorders. Now we find clear scientific evidence for at least a dozen medical benefits of Centella asiatica.
Gotu kola (Centella asiatica) has a long and successful history of use in traditional medicines. Traditional uses for Gotu kola have included:
Hepatitis
Syphilis
Gastrointestinal conditions
Asthma
Epilepsy
Varicose veins
Ulcers
Skin irritation
Swellings
And this is just the short list. Gotu kola has been a go to herb for herbal practitioners in Ayurveda, Chinese Traditional Medicine, Kampo Medicine (Japan), Thai Traditional Medicine, Indonesian Traditional Medicine, Hawaiian Traditional Medicine and many others.
Some of the above traditional uses for Gotu kola have been proven out in clinical research. Some have yet to be proven out. In this article, well discuss twelve medicinal uses for Gotu kola that have proven out in human clinical research.
Other names for Gotu kola
Among these various traditions, Gotu kola is also referred to as Kaki kuda, Gagan-gagan, Brahmi, Brahmi-buti, Panegowan, Hydrocotyle, Tungke-tunfke, Calingan rambat, Centella, Kerok batok, Tete karo, Kos tekosan, Thankuni, Lui gong gen, Pagaga, Tsubo-kusa, Puhe beta, Tete kadho, Papaiduh, Tungchian, Pegagan and Idrocotyle. Gotu kola has also been ref...

19:18

I Was In The Illuminati Im Going To Tell You Everything, Shocking Expose "IndyWatch Feed Health"

An ex illuminati member has penned a letter outlining the plans the secret society has in store for humanity in the next few years.

After spending 47 years as a high-ranking illuminati member, the anonymous insider says that he wants to reveal everything after the burden of keeping it a secret became too much to bear.

In an online post the illuminati insider reveals:

The process you have to go through in order to become a member
Shocking revelations about who Obama really is (he is much more evil than anyone realises apparently)
Information about Space flights program
How dark and satanic Denver, Colorado really is
The truth about aliens
This post will be about how the Illuminati recruited me and what exactly I had to go through.

When I was nineteen years old, I fell into some money through some connections with friends and some successful investments of some money that I had made throughout my childhood. I got involved in some backroom deals and saw my money begin to grow. As I attended college at Harvard in 1964, I begin to become increasingly rich, and my influence on campus grew as well through my participation in various clubs, and organizations. Some friends and I began to serve as quasi-stock brokers while still at Harvard. I made tons of cash during that year, and was very powerful and influential on campus.

One night as I was walking back to my dorm shortly after midnight, I was approached by two men in black suits. I initially assumed that they were going to investigate my business activity because some of it was not exactly legal. They asked me to come with them and I followed them into the basement of a two story house a couple streets over from my dorm room. They sat me down at a table and asked me if I was willing to make a deal. They would not tell me what deal I would be making, but just continually asked if I would be willing to make a deal. I half-assed agreed that I would, and that is when the biggest man that I have ever seen walked through some closet doors and sat down First of all, if you do not believe me then I am sorry. I am here to tell the truth, and nothing that is written by me is false exaggeration nor science fiction. This information is real, it is true, it is reality, and it is time for it to be told.

I was a member of the Illuminati for 47 years. I was recruited when I was 19 years old. I have posted here off and on over the past year. (Some of the posts are mine, others are my brothers, mainly they are his) The information that I am about to unfold is very revealing and very dangerous. I am one of seven people in the history of the Illuminati that have performed the Departure Ritual. I knew that I needed to get out when I had something revealed to me at a meeting in June of 2010. For years I was in line wit...

18:57

Vitamin A and C cosupplementation synergistically enhances reprogramming of differentiated cells to the naive state. "IndyWatch Feed Health"

PMID:  Epigenomics. 2017 Jun ;9(6):863-871. Epub 2017 May 30. PMID: 28554227 Abstract Title:  Modulating epigenetic memory through vitamins and TET: implications for regenerative medicine and cancer treatment. Abstract:  Vitamins A and C represent unrelated sets of small molecules that are essential to the human diet and have recently been shown to intensify erasure of epigenetic memory in naive embryonic stem cells. These effects are driven by complementary enhancement of the ten-eleven translocation (TET) demethylases - vitamin A stimulates TET expression, whereas vitamin C potentiates TET catalytic activity. Vitamin A and C cosupplementation synergistically enhances reprogramming of differentiated cells to the naive state, but overuse may exaggerate instability of imprinted genes. As such, optimizing their use in culture media will be important for regenerative medicine and mammalian transgenics. In addition, mechanistic perception of how these vitamins interact with the epigenome may be relevant for understanding cancer and improving patient treatment.

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18:37

Frankford lands local oversight with well-drilling ordinance "IndyWatch Feed Health"

FRANKFORD Lacking municipal teeth currently at the state level, the town of Frankford has gone the local route for authority over well-drilling within town limits.

Town council at its Aug. 7 meeting approved Ordinance 34 following second reading by council president Joanne Bacon.

The local ordinance gives the town authority to approve or deny any well sought to be drilled within town limits in efforts to:

  • safeguard against the threat to the towns aquifer;
  • allow oversight on usage of any wells;
  • restrict usage of wells within the Well Head Protection Zone designated by DNREC;
  • and to continue providing water to residents and businesses.

It shall be unlawful for any person to drill or otherwise construct, install, operate or use any well for the taking of water within the corporate limits without first securing approval of the town council and valid permit being issued by the DNREC (Department of Natural Resources and Environmental Control), said ordinance states.

Frankfords proposed ordinance coincides with a proposed amendment to Delaware Code Title 7 House Bill 38 that would give municipalities authority to sign off on well permits.

HB 38, which would have reverted to 2001 law that gave municipalities authority to sign off on well drilling, passed the state House of Representatives but died in committee in the state senate during this past General Assembly session.

A legislative change in the law in 2001 removed municipal governments from having approval authority over nonpotable wells.

That 2001 legislation came into play last year when town officials discovered a sharp drop in its water revenue. With DNRECs permission but not the towns, Mountaire, historically the towns top water user for decades, drilled its own well to meet what company spokesman Mike Tirrell said was high volume/pressure needs at its feed mill operation on Daisey Street.

That well went into operation in January 2016.

Facing substantial loss in annual water revenue, the town in August 2016 challenged the validity of DNRECs approval without any sign-off authority from the town with an appeal to the Delaware Environmental Appeals Board.

The appeal has not been heard, and is a poker chip in an agreement between the town and DNREC.

DNREC will forgive loans the town obtained for its water plant and system in return for the town dropping its appeal, conducting a water feasibility student and installing fluoride in its water system.

Frankfords local ordinance...

18:20

Honoring One Life to Save Others "IndyWatch Feed Health"

Kimberly Coffey was 17 years old and days away from high school graduation when she caught what she thought was a case of flu. Days later, her family was saying good-bye.

Many families would keep this story to themselves, but Kimberlys mother, Patti Wukovits, knew that she could do something to stop bacterial meningitis from taking other lives. In response, Patti started the Kimberly Coffey Foundation to educate and to advocate about meningococcal disease.

Tweens and teens need vaccines to protect against HPV and tetanus/diphtheria/pertussis as well as meningococcal disease, but the schedule is confusing and parents (and their children) are often very busy. Join our discussion about all of these topics by listening to our podcast. We promise that Kimberlys story is one you will long remember, and we ask you to remember Kimberly by sharing her story with others.

Also subscribe for future episodes at iTunesGoogle Play, or Stitcher. You can also listen to these episodes on Cast. Dont forget to leave a 5-star review!

...

17:43

Flavan 3-ol delayed disuse muscle atrophy by metabolic alteration. "IndyWatch Feed Health"

PMID:  Exp Gerontol. 2017 Aug 11. Epub 2017 Aug 11. PMID: 28807824 Abstract Title:  Flavan 3-ol delays the progression of disuse atrophy induced by hindlimb suspension in mice. Abstract:  Periods of skeletal muscle disuse, for example due to a sedentary lifestyle or bed rest, are associated with aging and can lead to muscle atrophy. We previously found that the flavan 3-ol fraction derived from cocoa (FL) enhanced energy expenditure with metabolic changes in skeletal muscle. In the present study, we examined the effect of FL on disuse muscle atrophy induced by hindlimb suspension in mice. Male C57BL/6J mice were assigned to four groups as follows: unsuspended-vehicle, unsuspended-FL, suspended-vehicle, and suspended-FL. Mice in the vehicle treatment groups were administered distilled water and those in the FL treatment groups were dosed with FL (50mg/kg/day) for 2weeks. The weights of the gastrocnemius (GC), tibialis anterior (TA), and soleus (SOL), but not the extensor digitorum longus (EDL), decreased significantly in mice with hindlimb suspension (-11.8%, -16.5%, and -41.0%, respectively). This reduction in GC, TA, and SOL mass was inhibited by FL (-5.3%, +2.0%, and -16.6%, respectively). The FL increased the EDL weight>20% with or without hindlimb suspension. The protein level of the ubiquitin ligase, muscle ring finger-1, in the SOL was significantly increased by hindlimb suspension, but inhibited by treatment with FL. Protein expression of p70S6 kinase in the SOL was significantly decreased by hindlimb suspension, and FL treatment inhibited this change. These results suggested that FL delayed disuse muscle atrophy by metabolic alteration.

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17:30

SAGE journal retracts three more papers after discovering faked reviews "IndyWatch Feed Health"

SAGE recently retracted three 2015 papers from one of its journals after the publisher found the articles were accepted with faked peer reviews. The retraction notices call out the authors responsible for submitting the reviews. This trio of retractions is the second batch of papers withdrawn by Technology in Cancer Research & Treatment over faked []

The post SAGE journal retracts three more papers after discovering faked reviews appeared first on Retraction Watch.

17:30

Acute chocolate intervention can significantly affect human metabolism. "IndyWatch Feed Health"

PMID:  J Proteome Res. 2017 Jul 7 ;16(7):2516-2526. Epub 2017 Jun 15. PMID: 28585834 Abstract Title:  Acute Consumption of Flavan-3-ol-Enriched Dark Chocolate Affects Human Endogenous Metabolism. Abstract:  Flavan-3-ols and methylxanthines have potential beneficial effects on human health including reducing cardiovascular risk. We performed a randomized controlled crossover intervention trial to assess the acute effects of consumption of flavan-3-ol-enriched dark chocolate, compared with standard dark chocolate and white chocolate, on the human metabolome. We assessed the metabolome in urine and blood plasma samples collected before and at 2 and 6 h after consumption of chocolates in 42 healthy volunteers using a nontargeted metabolomics approach. Plasma samples were assessed and showed differentiation between time points with no further separation among the three chocolate treatments. Multivariate statistics applied to urine samples could readily separate the postprandial time points and distinguish between the treatments. Most of the markers responsible for the multivariate discrimination between the chocolates were of dietary origin. Interestingly, small but significant level changes were also observed for a subset of endogenous metabolites. (1)H NMR revealed that flavan-3-ol-enriched dark chocolate and standard dark chocolate reduced urinary levels of creatinine, lactate, some amino acids, and related degradation products and increased the levels of pyruvate and 4-hydroxyphenylacetate, a phenolic compound of bacterial origin. This study demonstrates that an acute chocolate intervention can significantly affect human metabolism.

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17:12

2 Florida cancer centers accused of Medicare fraud and unsafe medical practices "IndyWatch Feed Health"

Until very recently a 50-page federal whistleblower lawsuit, against two of the nations largest cancer-care providers, has been under seal and kept from the public eye. But its now been made public and it doesnt look good. According to the lawsuit, Florida Cancer Specialists and 21st Century Oncology paid millions of dollars to each other in

17:10

Consumption of chocolate containing high concentrations of cocoa enhanced vascular endothelial function. "IndyWatch Feed Health"

PMID:  J Nutr. 2017 Aug 9. Epub 2017 Aug 9. PMID: 28794213 Abstract Title:  Brachial and Cerebrovascular Functions Are Enhanced in Postmenopausal Women after Ingestion of Chocolate with a High Concentration of Cocoa. Abstract:  Background: Cocoa contains polyphenols that are thought to be beneficial for vascular health.Objective: We assessed the impact of chocolate containing distinct concentrations of cocoa on cerebrovascular function and cognition.Methods: Using a counterbalanced within-subject design, we compared the acute impact of consumption of energy-matched chocolate containing 80%, 35%, and 0% single-origin cacao on vascular endothelial function, cognition, and cerebrovascular function in 12 healthy postmenopausal women (mean SD age: 57.3 5.3 y). Participants attended a familiarization session, followed by 3 experimental trials, each separated by 1 wk. Outcome measures included cerebral blood flow velocity (CBFv) responses, recorded before and during completion of a computerized cognitive assessment battery (CogState); brachial artery flow-mediated dilation (FMD); and hemodynamic responses (heart rate and blood pressure).Results: When CBFv data before and after chocolate intake were compared between conditions through the use of 2-factor ANOVA, an interaction effect (P = 0.003) and main effects for chocolate(P = 0.043) and time (P = 0.001) were evident. Post hoc analysis revealed that both milk chocolate (MC; 35% cocoa; P = 0.02) and dark chocolate (DC; 80% cocoa; P = 0.003) induced significantly lower cerebral blood flow responses during the cognitive tasks, after normalizing for changes in arterial pressure. DC consumption also increased brachial FMD compared with the baseline value before chocolate consumption (P = 0.002), whereas MC and white chocolate (0% cocoa) caused no change (P-interaction between conditions = 0.034).Conclusions: Consumption of chocolate containing high concentrations ofcocoa enhanced vascular endothelial function, which was reflected by improvements in FMD. Cognitive function outcomes did not differ between conditions; however, cerebral blood flow responses during these cognitive tasks were lower in those consuming MC and DC. These findings suggest that chocolatecontaining high concentrations of cocoa may modify the relation between cerebral metabolism and blood flow responses in postmenopausal women. This trial was registered at www.ANZCTR.orgau as ACTRN12616000990426.

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16:46

High dietary protein content has an antisteatotic and antiobesogenic effect in mice. "IndyWatch Feed Health"

PMID:  Biochim Biophys Acta. 2017 Jul ;1863(7):1789-1804. Epub 2017 Apr 28. PMID: 28457799 Abstract Title:  Dietary treatment of fatty liver: High dietary protein content has an antisteatotic and antiobesogenic effect in mice. Abstract:  Few studies have assessed the effect of changing ratios of dietary macronutrients on fat accumulation in adipose tissue and organs such as the liver in a 3n(n3) factorial design. We investigated the effects of 7 diets from a single manufacturer containing 11-58en% protein (casein), 0-81en% carbohydrates (CHO; sucrose, maltrodextrin-10 and corn starch), and 8-42en% fat (triheptanoin, olive oil or cocoa butter) in C57BL/6J mice, a good model for diet-induced obesity and fatty liver. The diets were fed for 3weeks to wild-type and hyperlipidemic male and female mice. Caloric intake was mainly determined by dietary fat. Body weight, liver lipid and cholesterol content, NFB activation, and fat-pad size decreased only in mice fed a high-proteindiet. A high dietary protein:CHO ratio reduced plasma FGF21 concentration, and increased liver PCK1 protein content and plasma triglyceride concentration. The dietary protein:CHO ratio determined hepatic expression of Pck1 and Ppargc1a in males, and Fgf21 in females, whereas the dietary CHO:fat ratio determined that of Fasn, Acaca1, and Scd1 in females. Hepatic glycogen content was determined by all three dietary components. Both hepatic PCK1 and plasma FGF21 correlated strongly and inversely with hepatic TG content, suggesting a key role for PCK1 and increased gluconeogenesis in resolving steatosis with a high-protein diet, with FGF21 expression reflecting declining cell stress. We propose that a diet containing ~35en% protein, 5-10en% fat, and 55-60en% carbohydrate will prevent fatty liver in mice without inducing side effects.

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16:20

Dark chocolate attenuates subsequent food intake in postmenopausal women. "IndyWatch Feed Health"

PMID:  Appetite. 2017 Sep 1 ;116:544-551. Epub 2017 May 29. PMID: 28572069 Abstract Title:  Consumption of dark chocolate attenuates subsequent food intake compared with milk and white chocolate in postmenopausal women. Abstract:  BACKGROUND: Chocolate has a reputation for contributing to weight gain due to its high fat, sugar and calorie content. However, the effect of varying concentrations of cocoa in chocolate on energy intake and appetite is not clear.OBJECTIVE: To compare the acute effect of consuming an isocaloric dose of dark, milk and white chocolate on subsequent energy intake, appetite and mood in postmenopausal women.METHODS: Fourteen healthy postmenopausal women (57.6  4.8yr) attended an introductory session followed by three experimental trials performed in a counterbalanced order at a standardised time of day, each separated by one week. Ad libitum energy intake, perceived appetite, mood and appetite-related peptides were assessed in response to consumption of 80% cocoa [dark chocolate], 35% cocoa [milk chocolate] and cocoa butter [white chocolate] (2099 kJ), prepared from a single-origin cacao bean.RESULTS: Ad libitum energy intake was significantly lower following dark (1355  750 kJ) compared with both milk (1693  969 kJ; P = 0.008) and white (1842  756 kJ; P = 0.001) chocolate consumption. Blood glucose and insulin concentrations were transiently elevated in response to white and milk chocolate consumption compared with the dark chocolate (P 

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15:26

These dogs are turning bright blue and one company is responsible "IndyWatch Feed Health"

Though there are many Western nations that cherish dogs as companions, going so far as to regularly have them groomed and parts of their fur dyed different colors, thats not the case with these stray dogs showing up with bright blue fur in Mumbai. Despite their comical appearance, this shade is anything but flattering or healthy for these

15:25

Fracking Giant Sues Citizen for Speaking out Against Fracking "IndyWatch Feed Health"

Fracking giant Cabot Oil & Gas Corp. is suing Dimock, Pennsylvania resident Ray Kemble and his attorneys for $5 million after Kemble accused the gas driller of polluting residential wells in Pennsylvania. Cabot alleges that Kemble and his lawyers extorted the company through a frivolous lawsuit. [1]

In 2013, an EPA official wrote in an internal report that fracking conducted by Cabot Oil & Gas Corp. caused methane to leak into domestic water wells in Dimock, completely contradicting Cabots assessment, which said the methane gas was naturally occurring. [2]

State regulators initially got involved in 2010 and said Cabots drilling contaminated local wells, though a subsequent EPA investigation in 2012 found the water posed no health risks to Dimock residents.

Though the 2013 report didnt exactly contract the EPAs finding that the water was safe to use, it did show that at least one official determined that Cabots work damaged water wells.

Read: Study: People Living Near Fracking Sites Suffer Severe Health Problems

Now, Cabot is suing Kemble, claiming that his efforts to garner media attention to his polluted well harmed the company. The energy company alleges in the suit that Kembles actions breached a 2012 settlement that was part of an ongoing federal class action lawsuit over Dimocks water quality.

Kemble says that even now his water burns the back of your throat, makes you gag, makes you want to puke. According to the outspoken Pennsylvanian, who, along with other community members, was featured in the 2010 documentary Gasland, said that things only got worse after Cabot fracked 3 wells near his house. [3]

In August 2017, scientists from the Agency for Toxic Substances and Disease Registry (ATSDR), a public health agency, again tested the water at Kembles home and about 2 dozen other houses.

A report released by the ATSDR in 2016 found contamination in some of Dimocks well-water, but the tests did not look at what was casing the contamination. [4]

Read: Fracking Contaminates Groundwater, Study Proves

George Stark, Cabots director of external affairs, said of the lawsuit:

Cabot will protect its rights and pursue justice against those who irresponsibly and maliciously abuse the legal system. [1]

...

15:16

Clary Sage Essential Oil: Facts, Benefits, Uses, and Recipes "IndyWatch Feed Health"

By

Clary sage essential oil comes from the clary sage herb (Salvia sclarea). The flowering plant has a floral or herby aroma that is pleasantly inviting, and deeply soothing on the nervous system.As a medicinal herb, clary sage has a long history and is especially useful for womens health and balancing hormones.It contains natural phytoestrogens that help deal with heavy menstrual cycles, hot flashes, and cramps.

As a result, clary sage oil is one of the more helpful essential oils. Clary sage essential oil is known for its antispasmodic, astringent, antiseptic, antifungal, anticonvulsive, antidepressant, sedative, nerve tonic, and anti-inflammatory properties. It is also known for its ability to support digestion, increase circulation, improve skin health, and fight leukemia.

The following article will help you learn about clary sage essential oil, and its many amazing benefits and uses.

...

15:15

Kratom Update: Operation Choke Point Ended "IndyWatch Feed Health"

OPERATION CHOKE POINT ENDED 
Policy ended that targeted legitimate business within the kratom community 

WASHINGTON, D.C.- [Last week], the DOJ announced the ending of the Obama-Era program called Operation Choke Point.  This program had attempted to cut off sources of credit for businesses targeted by the department, including many working within the kratom industry.

Dave Herman, the Chairman of the American Kratom Association (AKA) stated, We have been working with lawmakers for months to discontinue this program due to its impact on those within the kratom community.  We felt that this was significantly hurting legitimate businesses across the country.  We are encouraged by the actions of the DOJ.

Over the last several months, experiences started to surface of many kratom businesses and consumers having their credit card transactions restricted.

The AKA is hopeful this will be a major step in restoring the freedom of access to kratom for consumers from legitimate businesses, Herman continued.

According to Assistant Attorney General Stephen Boyd, All of the Departments bank investigations conducted as part of Operation Choke Point are now over, the initiative is no longer in effect.

The AKA would like to thank Senator Orrin Hatch (UT), who has been a champion for kratom and the rights for individuals to make their own decisions about their well-being, for his efforts in ending Operation Choke Point.

ABOUT AKA

The America Kratom Association, a consumer-based non-profit organization, is here to set the record straight, giving a voice to those suffering and protecting our rights to possess a...

15:09

Controversy over fake meat burger heats up as documents reveal FDA safety concerns "IndyWatch Feed Health"

By Dr. Mercola Three years ago, I wrote about the safety questions looming over the meat substitute known as Quorn, a fungus-based ferment that hit the U.S. market in 2002. Quorn was originally developed by Imperial Chemical Industries, one of the largest chemical companies in the U.K. The fungus used to make quorn is Fusarium venenatum,

14:27

Loneliness, Isolation Are Bigger Health Threats than Obesity "IndyWatch Feed Health"

Obesity always makes headlines for being one of the biggest health threats in the U.S. (as well as globally). But according to a recent study, loneliness and social isolation may be even more deadly than obesity or than smoking 15 cigarettes a day. Lack of social connection can be so deadly, in fact, that the feeling of loneliness is a stronger predictor of mortality than obesity. [1]

Social isolation and loneliness are different, but they are typically connected. Social isolation, or lack of social connection, means you have a lack of contact with other people. Loneliness is more about lacking an emotional connection, and its something you can feel even if youre surrounded by people.

Julianne Holt-Lunstad, who is a professor of psychology and neuroscience at Brigham Young University in Provo, Utah, and her colleagues discovered that social isolation and loneliness may increase the risk of premature death by as much as 50%.

The researchers came to these conclusions by conducting two meta-analyses of studies exploring potential links between loneliness, social isolation, and mortality. [2]

Their findings were presented at the 125th Annual Convention of the American Psychological Association, held in Washington, D.C.

More than 300,000 adults encompassing 148 studies were involved in the first meta-analysis, while the second included 70 studies involving over 3.4 million adults.

In the first meta-analysis, Holt-Lunstad and her team found that the risk of dying early was 50% lower among people who said they had good social connections, compared with those who reported being more socially isolated.

The team found in the second meta-analysis that loneliness, social isolation, and living alone all increased the risk of early death.

Overall, the combination of loneliness, social isolation, and living alone was found to increase the risk of premature death as much, if not more, than obesity and other major health conditions. By comparison, obesity increases the risk of dying before age 70 by about 30%. [1] [3]

Holt-Lunstad said:

There is robust evidence that social isolation and loneliness significantly increase risk for premature mortality, and the magnitude of the risk exceeds that of many leading health indicators. [3]

This, according to Holt-Lunstad, is worrisome considering that the aging population is growing. [2]

Indeed, many nations around the world now suggest we are facing a loneliness epidemic. The challenge we face now is what...

14:25

No Bake almond butter cacao bars "IndyWatch Feed Health"

These dairy-free, gluten-free, and refined sugar-free treats yield 8 square bars or 16 smaller bars. Enjoy! Many people avoid snacks because they believe it will contribute to weight gain when in actuality it helps to maintain a healthy weight and keep energy levels at an ultimate high, avoiding cravings of junk food and refined sugar.  However,

13:26

Is Metformin a Viable Anti-Aging Solution? "IndyWatch Feed Health"

If youre a longevity enthusiast, Ive got some news for you. After all of these years, aging itself is on its way to be officially classified as a disease. Of course, its taken decades of improving life expectancy and survival rates due to better living standards and lifestyles, but it is most likely worth the wait.

Why?

This could mean that antiaging will be taken more seriously by the health industry and society as a whole, including insurance companies. It may also raise the value of prevention, instead of just waiting for health problems to appear or reach a certain level of severity before treatment.

So, What Happened Exactly?

Two years ago, researchers managed to convince the United States Food and Drug Administration (FDA) to approve a human lifespan study of metformin, which is currently used for blood sugar control. But it may end up being the first drug approved specifically to treat aging.

The study, known as the TAME Study (Targeting Aging With Metformin) started up in 2016, aiming to enroll 3,000 people aged 70-80 and study the effects of metformin over 5-7 years. Everyone must be at risk of or have one or more of the following: cancer, heart disease, or dementia. If metformin can delay or prevent these and delay death, the next step is to test it in younger people.

But why Metformin?

High blood sugar and insulin resistance are key factors in aging and other complex, chronic illnesses, such as cardiovascular disease and cancer. But this is not the only way that metformin could fight aging. Metformin works by acting on an enzyme called AMPK (adenosine monophosphate-activated protein kinase), which regulates how cells process energy.

AMPK boosts metabolism, which may aid weight loss by burning more sugar and fat; it improves blood flow and body composition; it aids cell detoxification and renewal; and it has antioxidant, anti-inflammatory effects.

On the other hand, unaddressed aging results in slowing metabolism and weight gain; muscle loss; poor circulation and detoxification, and a vicious cycle of inflammation.

Is Metformin Really the Best Solution to Aging?

Unfortunately, no. Aging is a complex disease involving chronic inflammation, so health and longevity promoting strategies that target the whole person are likely to be far more effective. As it is multifactorial, focusing on one aspect of it is probably not the best strategy, as other complex, chronic diseases do not respond to this method.

Metformin is not without side effects, either. It has a black box warning for the rare-but-dangerous side effect...

02:36

DIFFERING PERSPECTIVES ON WATER FLUORIDATION "IndyWatch Feed Health"

Fair use excerpts from this lengthy article:

According to a University of Toronto Faculty of Dentistry, Water Fluoridation: Questions and Answers, 42.6% of Canadas population, on public water supplies, is receiving water fluoridation.

The level of the population receiving fluorides ranges from 75.9% in Ontario to 0% in Nunavut and Yukon.

and Qubec at 6.4%.

We spoke with Paul Connett PhD, Senior Advisor to the Fluoride Action Network

When asked to make his case against the use of the additive, Connett said he wants people to recognize that nature or evolution, call it what you like, did not find a use for fluoride in the body. Though fluoride is naturally occurring and there is no use for it in the body he found it astounding that we would add this artificially to our water. Connett suggests the substance is highly toxic.

Connett argued that the low levels contained in it, mothers milk offers protection to the baby from fluoride. He continued by saying water fluoridation removes [that] protection.

*Original article online at http://www.watertoday.ca/ts-fluoridation-differing-perspectives.asp

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Sunday, 20 August

21:18

Vaccines cause SIDS? Not supported by Boatmon vs HHS case "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

This is about the case of little J. B. Boatmon, who was born born four weeks prematurely, at the 36th week.  However, he rebounded from his early start, and at his four-months well baby pediatric visit, on September 2 was doing very well and found healthy.  At that visit, J.B. had the routine 4 months

Skeptical Raptor

20:45

Fluoridated Kentucky had the fifth highest rate of tooth loss among people 65 and over in 2012 "IndyWatch Feed Health"

Note from Fluoride Action Network: This is an excerpt from a much longer article. The Centers for Disease Control and Prevention ranked Kentucky as the Number One state for the fluoridation of public drinking water. CDC noted that the percentage of public drinking water supplies in Kentucky was 99.9% in 2012 and 2014, while this article gives the rate as 96%.

Kentucky: Fifth highest rate of tooth loss

Where does Kentucky rank? In 2012, Kentucky had the fifth highest rate of tooth loss among people 65 and over in the nation. Four out of 10 of our children reportedly never visited a dentist, and over 16,000 uninsured residents turned to an ER rather than a dentist for dental pain.

Lack of dental coverage and affordability are just a part of the equation. A lack of education regarding the importance of oral health, fear of visiting a dentist, inconvenient location or time, particularly among working families with school age children, lack of transportation, distance to, and trouble finding a dentist are all contributing factors.

That is why the work of the Kentucky Oral Health Program (KOHP), and more recently, the Kentucky Oral Health Coalition, is so significant. A part of the Kentucky Cabinet for Health and Family Services, the Kentucky Oral Health Program has a longstanding history of service to Kentucky. At the time it was formed in 1928, KOHP was only the third state public dental health program in the nation.

Over the years, KOHP has made water fluoridation one of its major priorities. Today, our state is considered a national leader in that area, providing approximately 96 percent of Kentuckians with fluoridated water. In addition, KOHP also offers a fluoride supplement program for preschool children whose home drinking water supply is fluoride deficient. The American Dental Society, the Centers for Disease Control, and the Association of State and Territorial Dental Directors have all recognized Kentucky for its efforts.

In 2002, Kentucky also became one of the first states in the nation to introduce a school-based Dental Sealant program for children who might otherwise not have access to regular dental care. Dental sealants are thin plastic coatings applied to the chewing surfaces of back teeth to protect them against tooth decay. Sealants have been associated with reducing the incidence of tooth decay by as much as 40-60 percent.

In more recent years, KOHP has been working in conjunction with the Kentucky Health Coalition and other stakeholders to achieve both stat...

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Saturday, 19 August

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Thursday, 17 August

23:20

Medical exemption abuse hurting Californias vaccine uptake "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Since the enactment of Californias SB277, which prevents parents from using religious or personal beliefs to excuse their children from vaccinations, has lead to much higher vaccine uptake rates in California schools. The law still allows medical exemptions, which are medically-related reasons for not vaccinating, such as allergies to ingredients in the vaccine. Unfortunately, this

Skeptical Raptor

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Wednesday, 16 August

21:30

California SB277 lawsuit update judge rejected Torrey-Love "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

On August 15, 2017 Judge Charles D. Wachob from the Placer County Superior court granted the states demurrer to the California SB277 lawsuit (known as Torrey-Love).  In lay terms, dismissed the suit without leave to amend. Demurrer is generally granted when, assuming all the facts plaintiffs claimed are true, the court sees no legal basis

Skeptical Raptor

Tuesday, 15 August

23:08

Alternative medicine cancer treatment increased death rate "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

One of the most annoying subjects that catch my eye on a regular basis is an alternative medicine cancer treatment that pervades the internet. I find it disheartening when people risk their lives for unproven pseudoscience over treatments that are supported with real scientific evidence. Moreover, it is not my opinion that an alternative medicine cancer

Skeptical Raptor

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