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Tuesday, 07 August

23:29

What Separates Leadership and Delegate Decision-Making? "IndyWatch Feed Health"

Leaders are more willing to take responsibility for making decisions that affect the welfare of others. In a new study, researchers at the University of Zurich identified the cognitive and neurobiological processes that influence whether someone is more likely to take on leadership or to delegate decision-making.

23:04

Phloretin induces apoptosis of BEL-7402 cells in vitro. "IndyWatch Feed Health"

PMID:  Nan Fang Yi Ke Da Xue Xue Bao. 2008 Jul ;28(7):1249-51. PMID: 18676276 Abstract Title:  [Phloretin induces apoptosis of BEL-7402 cells in vitro]. Abstract:  OBJECTIVE: To examine the effect of phloretin on apoptosis of BEL-7402 cells.METHODS: The viability changes of BEL- 7402 cells as a result of phloretin-induced toxicity were analyzed using MTT assay, and the cell morphology changes were observed with fluorescence microscope. Flow cytometry was used to analyze the cell cycle and mitochondrial membrane potential changes, and chromogenic substrate assay performed to detect caspase activity.RESULTS: Phloretin induced obvious cytotoxicity against BEL-7402 cells with IC50 of 89.23 microg/mL. The growth curve demonstrated decreased growth of the cells as phloretin concentration increased. Cell apoptosis occurred 24 h after treatment with 40-160 microg/mL phloretin. Morphological, the cells exposed to phloretin exhibited nuclear chromatin condensation and increased fluorescence intensity. The activity of caspase-9 reached the peak level 12 h after phloretin exposure, and leak levels of caspase-6 and caspase-3 activities occurred 18 and 24 h after the exposure, respectively.CONCLUSION: Phloretin can induce BEL-7402 cell apoptosis though the mitochondrial pathway.

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22:56

Would You Go Camping In This Mansion Tent From Cabelas? "IndyWatch Feed Health"

Would you live in a tent? No? Think again. The Cabelas Ultimate Alaknak tent can hold your family, friends, dogs, gear, and then some. Its not even a joke. The tent is 13 by 17 feet wide, which is the size of a spacious apartment. The 10 sturdy poles hold it up under any condition.... View Article

The post Would You Go Camping In This Mansion Tent From Cabelas? appeared first on Healthy Holistic Living.

22:50

If You Can Solve This Math Equation, Then You Really Are A Genius! Can You Do It? "IndyWatch Feed Health"

Lets be honest everybody wants to be considered a genius, but when it comes to proving our minds abilities, were often somewhat less than thrilled about putting ourselves to the test. This seems especially true in the case of math, since so many people detest it and its strict rules, resulting in feelings of shyness... View Article

The post If You Can Solve This Math Equation, Then You Really Are A Genius! Can You Do It? appeared first on Healthy Holistic Living.

22:47

Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells. "IndyWatch Feed Health"

PMID:  Biosci Biotechnol Biochem. 1999 Apr ;63(4):719-25. PMID: 10361685 Abstract Title:  Phloretin-induced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells. Abstract:  The dihydrochalcone phloretin induced apoptosis in B16 mouse melanoma 4A5 cells and HL60 human leukemia cells. Phloretin was suggested to induce apoptosis in B16 cells mainly through the inhibition of glucose transmembrane transport. The phloretin-induced apoptosis in B16 cells was inhibited by actinomycin D, Ac-YVAD-CHO caspase-1-like inhibitor, and Ac-DEVD-CHO caspase-3-like inhibitor. During the induction of apoptosis by phloretin, the expression of Bax protein in B16 cells increased and the levels of p53, Bcl-2, and Bcl-XL proteins did not change. Our results suggested that phloretin induced apoptosis through the promotion of Bax protein expression and caspases activation. On the other hand, phloretin may induce apoptosis in HL60 cells through the inhibition of protein kinase C activity because phloretin inhibited protein kinase C activity in HL60 cells more than that in B16 cells. The phloretin induced-apoptosis in HL60 cells was not inhibited by actinomycin D and the caspase-1-like inhibitor, but slightly inhibited by the caspase-3-like inhibitor. Phloretin reduced the level of caspase 3 protein in HL60 cells, but not the level of the Bcl-2 protein. Phloretin did not increase the level of Bax protein. Phloretin was suggested to induce apoptosis in HL60 cells through the inhibition of protein kinase C activity, followed by the pathway, which is different from that in B16 cells.

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22:42

Keep Your Sciatic Back And Hip Pain Under Control With 6 Stretches "IndyWatch Feed Health"

Never skip your daily stretch! It is crucial for flexibility and strengthening your muscles. Regular stretching can prevent and improve minor discomfort, injuries and sciatic nerve pain in your back and hip. Do these simple stretches regularly, and thank us later. 6 Stretches To Keep Sciatic Back And Hip Pain Under Control Camel Pose This... View Article

The post Keep Your Sciatic Back And Hip Pain Under Control With 6 Stretches appeared first on Healthy Holistic Living.

22:39

17 F*cks You Should Finally Stop Giving When Youre A Grown And Mature Person "IndyWatch Feed Health"

Life is hard is a phrase we hear a lot, especially as we grow into adulthood and set out on our trail through life. There are bills to pay, responsibilities to follow through on, consequences and random occurrences to be tended to, as well as a lot of inner dialogue to contend with through all... View Article

The post 17 F*cks You Should Finally Stop Giving When Youre A Grown And Mature Person appeared first on Healthy Holistic Living.

22:37

Pumpkin seed has potential as a hypoglycemic food. "IndyWatch Feed Health"

PMID:  Nutr Res. 2018 Aug ;56:90-97. Epub 2018 Apr 26. PMID: 30055778 Abstract Title:  Addition of pooled pumpkin seed to mixed meals reduced postprandial glycemia: a randomized placebo-controlled clinical trial. Abstract:  We investigated if pumpkin and flaxseeds could improve postprandial glycemic, food intake, and appetitive responses. Herein, we hypothesize based on the literature that pumpkin seed has potential to lower postprandial glycemic effects. Therefore, we conducted a randomized, single-blind, placebo-controlled, crossover design study involving normoglycemic adults (food intake: n = 25; glycemia: n = 15). Three high-carbohydrate mixed meals presenting no seed (control [C]) or 65 g of the tested seeds (pumpkin seed [P] or flaxseed [F]) were consumed in 3 nonconsecutive days. Test meals had similar nutritional composition. Blood glucose was measured by capillary finger blood at 0 (immediately before), 15, 30, 45, 60, 90, and 120 minutes after the ingestion of each meal, and the incremental area under glycemic response curves (iAUC) were calculated. Appetitive responses were assessed, and dietary records were used to evaluate food intake on testing days. Glucose iAUC was significantly lower in P compared with C (reduction of ~35%, P = .025). There was no significant differences in glucose iAUC between F and C (P = .257). Glycemic response at each time point did not differ between C, P, and F (P= .238). Fiber consumption was higher in F (P = .009) than in C, but there were no differences in appetitive responses, energy, or macronutrient consumptions between dietary interventions. Acute consumption of 65 g of pumpkin seed markedly reduced postprandial glycemia. Pumpkin seed has potential as a hypoglycemic food, which now deserves to be confirmed in long-term studies.

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22:12

Phloretin could be therapeutic for treating TLR2-mediated inflammatory immune diseases. "IndyWatch Feed Health"

PMID:  Nutrients. 2018 Jul 5 ;10(7). Epub 2018 Jul 5. PMID: 29976865 Abstract Title:  Phloretin as a Potent Natural TLR2/1 Inhibitor Suppresses TLR2-Induced Inflammation. Abstract:  Toll-like receptor 2 (TLR2) responses are involved in various inflammatory immune disorders. Phloretin is a naturally occurring dietary flavonoid that is abundant in fruit. Here, we investigated whether the anti-inflammatory activity of phloretin is mediated through TLR2 pathways, and whether phloretin acts as an inhibitor of TLR2/1 heterodimerization using the TLR2/1 agonist PamCSK. We tested the effects of phloretin on tumor necrosis factor (TNF)- production induced by various TLRs using known TLR-specific agonists. Phloretin significantly inhibited PamCSK-induced TRL2/1 signaling in Raw264.7 cells compared to TLR signaling induced by the other agonists tested. Therefore, we further tested the effects of phloretin in human embryonic kidney (HEK) 293-hTLR2 cells induced by PamCSK, and confirmed that phloretin has comparable inhibition of TLR2/1 heterodimerization to that induced by the known TLR2 inhibitor CU-CPT22. Moreover, phloretin reduced the secretion of the inflammatory cytokines TNF- and interleukin (IL)-8 in PamCSK-induced HEK293-hTLR2 cells, whereas it did not significantly reduce these cytokines under PamCSK-induced activation. Western blot results showed that phloretin significantly suppressed PamCSK-induced TLR2 and NF-B p65 expression. The molecular interactions between phloretin and TLR2 were investigated using bio-layer interferometry and in silico docking. Phloretin bound to TLR2 with micromolar binding affinity, and we proposed a binding model of phloretin at the TLR2TLR1 interface. Overall, we confirmed that phloretin inhibits the heterodimerization of TLR2/1, highlighting TLR2 signaling as a therapeutic target for treating TLR2-mediated inflammatory immune diseases.

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22:00

Dr. Ron Unfiltered Uncensored Episode 270 Dr Jaffe and Predictive Biomarkers "IndyWatch Feed Health"

Dr. Ron who is a Fellow of the American Academy of Family Practice and a Charter member of the American Academy of Emergency Medicine and a licensed Acupuncturist is joined by Dr. Gerry and Dr. Dan to host this weekly podcast on the latest medical news and information We are not influenced by Big Pharma and will give you honest opinions on the news, medical devices and we have terrific guests. We have over 150 years of combined medical experience and are grateful to share it with you.  You can hear us on BlogTalkRadio, Stitcher, iTunes, GooglePlay, Alexa, and others. Reach us live at 347-989-8899

21:49

Farmer Converts 40,000 Acres into Largest Organic Farm in Canada "IndyWatch Feed Health"

Farmer Converts 40,000 Acres into Largest Organic Farm in Canada

By 

In what could possibly be the worlds largest agricultural feat, Canadian farmer Travis Heide is in the process of converting his 40,000-acre farm entirely to organic.

Heides farm is large enough to produce 2,200,000 bushels of wheat per year. Although he has been mostly quiet about his transition to organic, his company Organics Canada Ltd. is set to boom as he will begin producing oats, lentils, peas, wheat and hemp all organically.

Currently, the farm is half-organic and half-conventionally grown, but by 2020 Travis plans to convert his entire farm to organic.

Well be 75 percent organic in 2019, and if we dont add anything else, in 2020 well be 100 percent organic. ~Travis Heide

The size and ambition of his operation is even more impressive considering Heide just started farming full-time in 2014.

I have never heard of anything like thatThe biggest one Ive heard of before is maybe 20,000 [acres]. ~Laura Telford, Organic Development Specialist, Manitoba Agriculture

In his early years, Travis grew up working on his parents farm near Moosomin, Saskatche...

21:37

French Oncologist Analysis of Gardasil Vaccine Finds Higher Rates of Cervical Cancer Associated with High Vaccination Rates "IndyWatch Feed Health"

Gardasil-vaccine-danger

by Brian Shilhavy
Editor, Health Impact News

A medical doctor in France, Dr. Grard Delpine, an oncologist, has published an analysis of the HPV vaccine Gardasil on the independent news site, Agora Vox, showing how increased rates of Gardasil vaccinations are actually correlated with a higher rate of cervical cancer.

The analysis was published as an Open letter to parliamentarians, and to all citizens in response to a recent meeting between French President Emmanuel Macron and thirty leaders of the worlds largest pharmaceutical groups, and to the call among some politicians to make the HPV vaccine Gardasil mandatory in France.

Pointing out that Gardasil only targets 2 to 5% of the 200 known strains of the human papillomavirus, Dr. Delpine explains that there is no evidence that Gardasil protects against cancer.

Instead of reducing the risk of invasive cancer of the cervix, HPV vaccines keep it at a high level or increase it!

Using statistics from several countries, Dr. Delpine shows that cervical cancer was decreasing in all these countries due to the implementation of regular pap smears.

However, in some countries where mass Gardasil vaccination took place, the incidence of cervical cancer actually increased.

Since France currently has a low rate of Gardasil vaccination, Dr. Delpine urges the French government to not make Gardasil vaccination mandatory.

A compulsory health measure should not be based on faith in vaccination or hidden conflicts of interest, but on proven facts, verifiable by every citizen. However, the facts established by the official records of cancer registries show that HPV vaccination does not protect against invasive cancer of the cervix, but seems rather to maintain its frequency at a high level, and sometimes even increase it.

Let us fight against this bill that threatens our children, by informing everyone, our MP, our senator, our elected officials, that no one may be unaware (of t...

21:31

Pterostilbene inhibited lipopolysaccharide-induced inflammatory response in RAW264.7 macrophages. "IndyWatch Feed Health"

PMID:  Molecules. 2018 May 11 ;23(5). Epub 2018 May 11. PMID: 29751609 Abstract Title:  Pterostilbene and 4'-Methoxyresveratrol Inhibited Lipopolysaccharide-Induced Inflammatory Response in RAW264.7 Macrophages. Abstract:  Pterostilbene (Pte) and 4-Methoxyresveratrol (4MR) are methylated derivatives of resveratrol. We investigated the anti-inflammatory effect of Pte and 4MR in lipopolysaccharide (LPS)-stimulated RAW264.7 murine macrophages. Both Pte and 4MR significantly reduced LPS-induced nitric oxide release by inhibiting the inducible nitric oxide synthase mRNA expression. Moreover, both of them inhibited LPS-induced mRNA expression of inflammatory cytokines including monocyte chemoattractant protein (MCP)-1, interleukin (IL)-6 and IL-1, and tumor necrosis factor (TNF-), and attenuated LPS-induced nuclear factor-B (NF-B) activation by decreasing p65 phosphorylation. In addition, 4MR but not Pte inhibited LPS-induced the activator protein (AP)-1 pathway in RAW 264.7 macrophages. Further study suggested that Pte had an inhibitory effect on extracellular regulated protein kinases (ERK) and p38 activation, but not on c-Jun N-terminal kinase (JNK), while 4MR had an inhibitory effect on JNK and p38 activation, but not on ERK. Taken together, our data suggested that Pte induced anti-inflammatory activity by blocking mitogen-activated protein kinase (MAPK) and NF-B signaling pathways, while 4MR showed anti-inflammatory activity through suppression of MAPK, AP-1, and NF-B signaling pathways in LPS-treated RAW 264.7 macrophages.

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21:20

French Oncologist Analysis of Gardasil Vaccine Finds Higher Rates of Cervical Cancer Associated with High Vaccination Rates "IndyWatch Feed Health"

Gardasil-vaccine-danger

by Brian Shilhavy
Editor, Health Impact News

A medical doctor in France, Dr. Grard Delpine, an oncologist, has published an analysis of the HPV vaccine Gardasil on the independent news site, Agora Vox, showing how increased rates of Gardasil vaccinations are actually correlated with a higher rate of cervical cancer.

The analysis was published as an Open letter to parliamentarians, and to all citizens in response to a recent meeting between French President Emmanuel Macron and thirty leaders of the worlds largest pharmaceutical groups, and to the call among some politicians to make the HPV vaccine Gardasil mandatory in France.

Pointing out that Gardasil only targets 2 to 5% of the 200 known strains of the human papillomavirus, Dr. Delpine explains that there is no evidence that Gardasil protects against cancer.

Instead of reducing the risk of invasive cancer of the cervix, HPV vaccines keep it at a high level or increase it!

Using statistics from several countries, Dr. Delpine shows that cervical cancer was decreasing in all these countries due to the implementation of regular pap smears.

However, in some countries where mass Gardasil vaccination took place, the incidence of cervical cancer actually increased.

Since France currently has a low rate of Gardasil vaccination, Dr. Delpine urges the French government to not make Gardasil vaccination mandatory.

A compulsory health measure should not be based on faith in vaccination or hidden conflicts of interest, but on proven facts, verifiable by every citizen. However, the facts established by the official records of cancer registries show that HPV vaccination does not protect against invasive cancer of the cervix, but seems rather to maintain its frequency at a high level, and sometimes even increase it.

Let us fight against this bill that threatens our children, by informing everyone, our MP, our senator, our elected officials, that no one may be unaware (of thes...

21:20

Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression. "IndyWatch Feed Health"

PMID:  Acta Biochim Biophys Sin (Shanghai). 2018 Jun 29. Epub 2018 Jun 29. PMID: 29961897 Abstract Title:  Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression. Abstract:  Mantle cell lymphoma (MCL) is an aggressive and mostly incurable B-cell malignancy with frequent relapses after an initial response to standard chemotherapy. Therefore, novel therapies are urgently required to improve MCL clinical outcomes. In this study, MCL cell lines were treated with pterostilbene (PTE), a non-toxic natural phenolic compound primarily found in blueberries. The antitumor activity of PTE was examined by using the Cell Counting Kit-8, apoptosis assays, cell cycle analysis, JC-1 mitochondrial membrane potential assay, western blot analysis, and tumor xenograft models. PTE treatment induced a dose-dependent inhibition of cell proliferation, including the induction of cell apoptosis and cell cycle arrest at the G0/G1 phase. Moreover, the PI3K/Akt/mTOR pathway was downregulated after PTE treatment, which might account for the anti-MCL effects of PTE. Synergistic cytotoxicity was also observed, both in MCL cells and in xenograft mouse models, when PTE was administered in combination with bortezomib (BTZ). The antitumor effects of PTE shown in our study provide an innovative option for MCL patients with poor responses to standardized therapy. It is noteworthy that the treatment combining PTE with BTZ warrants clinical investigation, which may offer an alternative and effective MCL treatment in the future.

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21:00

Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients. "IndyWatch Feed Health"

PMID:  Nutr J. 2016 10 12 ;15(1):86. Epub 2016 Oct 12. PMID: 27733151 Abstract Title:  Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial). Abstract:  BACKGROUND: Water-soluble dietary fibers intake may help control blood glucose and body weight.OBJECTIVE: The objective of the study was to determine whether soluble fiber supplementation from psyllium improves glycemic control indicators and body weight in type 2 diabetic patients.METHOD: Forty type 2 diabetes patients, non-smoker, aged>35 years were stratified to different strata according to sex, age, body mass index (BMI) and fasting blood sugar level (FBS) and randomly assigned into two groups; The intervention group which consists of 20 participants was on soluble fiber (10.5 g daily), and the control group which consist of 20participants continued on their regular diet for eight weeks duration.RESULTS: After 8 weeks of intervention, soluble fiber supplementation showed significant reduction in the intervention group in BMI (p

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20:48

A moderate carbohydrate diet with psyllium reduces fasting plasma insulin and tumor necrosis factor- in patients with type 2 diabetes mellitus. "IndyWatch Feed Health"

PMID:  J Diet Suppl. 2018 Jul 4 ;15(4):507-515. Epub 2017 Sep 28. PMID: 28956658 Abstract Title:  Short-Term Supplementation of a Moderate Carbohydrate Diet with Psyllium Reduces Fasting Plasma Insulin and Tumor Necrosis Factor- in Patients with Type 2 Diabetes Mellitus. Abstract:  The purpose of this study was to compare effects of a moderate carbohydrate diet supplemented with psyllium with those of a lower carbohydrate diet supplemented with placebo powder on glycemic control in patients with type 2 diabetes (T2D). In an open randomized controlled trial, 37 patients with T2D with body mass index (BMI) 25-35 kg/m2 received either a low-energy, moderate carbohydrate diet plus 7 grams of psyllium powder (MoCyllium group) or a low-energy, lower carbohydrate diet plus placebo powder (LoCarb group) for 2 weeks. Fasting and 2-hour postprandial plasma glucose, insulin, and tumor necrosis factor- (TNF-)as well as the homeostasis model assessment of insulin resistance (HOMA-IR) were determined at the beginning and end of the 2-week period. Postprandial samples were obtained after ingestion of a standardized breakfast meal in both groups. Body weight change did not differ between the two groups. There was no significant intervention effect on fasting plasma glucose. Fasting plasma insulin and TNF- significantly decreased from baseline in the MoCyllium group (p = .01). The differences of absolute change of insulin and TNF- between the groups were statistically significant (p = .002 and p =.017, respectively). Insulin sensitivity, evaluated by HOMA-IR, increased significantly in the MoCyllium group (p = .016), and comparison of absolute change between the groups showed a trend toward statistical significance. No statistical differences were detected among postprandial glucose, insulin, and TNF- concentrations. The finding supports the concept that in diabetic patients with cultural preferences to a higher carbohydrate diet, an increase in soluble fiber intake should be encouraged.

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20:29

NY Times vaccine science hostage op-ed is a gift "IndyWatch Feed Health"

By J.B. Handley, Director, World Mercury Project Underneath one of the more absurd cause-and-effect conjectures ever undertaken by a reporter lies a treasure-trove of truth about vaccine safety science. If the study results implicate vaccines, scientists are pressured to suppress. NEW YORK, New YorkI just got finished reading Melinda Wenner Moyers Op-Ed in the New York []

The post NY Times vaccine science hostage op-ed is a gift appeared first on Health Nut News.

20:26

The best vitamin to help stop tumor cells in their tracks "IndyWatch Feed Health"

Each year during the anniversary week of Mercola.com, we recognize a Game Changer, someone whose work stands as a great service to humanity by making a significant contribution to improving peoples health. Previous recipients include Dr. Fred A. Kummerow for his lifes work on trans fats, Thomas Seyfried, Ph.D., for his advancement of cancer as a metabolic disease, []

The post The best vitamin to help stop tumor cells in their tracks appeared first on Health Nut News.

20:22

Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice. "IndyWatch Feed Health"

PMID:  Br J Nutr. 2017 Nov ;118(9):661-672. PMID: 29185927 Abstract Title:  Supplemental psyllium fibre regulates the intestinal barrier and inflammation in normal and colitic mice. Abstract:  Our previous study demonstrated that supplemental psyllium fibre increased cytoprotective heat-shock protein (Hsp) 25 levels in the intestinal cells of mice. Here, we examined the effect of psyllium fibre on colonic gene and protein expression and faecal microbiota in normal and colitic mice to improve the understanding of the preventive role of the supplement. DNA microarray analysis revealed that a 10 % psyllium fibre diet administered for 5 d up-regulated eleven extracellular matrix (ECM)-associated genes, including collagens and fibronectins, in normal mice. Acute colitis was induced using dextran sodium sulphate (DSS) in mice that were administered a pre-feeding 5 to 10 % psyllium fibre diet for 5 d. Psyllium fibre partially ameliorated or resolved the DSS-induced colon damage and inflammation characterised by body weight loss, colon shortening, increased levels of pro-inflammatory cytokines and decreased tight junction protein expression in the colon. Analysis of faecal microbiota using denaturing gradient gel electrophoresis of the PCR-amplified 16S rRNA gene demonstrated that psyllium fibre affected the colonic microbiota. Intestinal permeability was evaluated by growing intestinal Caco-2 cell monolayers on membrane filter supports coated with or without fibronectin and collagen. Cells grown on collagen and fibronectin coating showed higher transepithelial electrical resistance, indicating a strengthening of barrier integrity. Therefore, increased Hsp25 levels and modification of colonic ECM contribute to the observed psyllium-mediated protection against DSS-induced colitis. Furthermore, ECM modification appears to play a role in the strengthening of the colon barrier. In conclusion, psyllium fibre may be useful in the prevention of intestinal inflammatory diseases.

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20:18

Treatment of functional constipation by Psyllium seed in patients with gastroesophageal reflux disease leads to improvement and lessens its recurrence. "IndyWatch Feed Health"

PMID:  J Evid Based Integr Med. 2018 Jan-Dec;23:2515690X18763294. PMID: 29607676 Abstract Title:  Comparing the Effect of Psyllium Seed on Gastroesophageal Reflux Disease With Oral Omeprazole in Patients With Functional Constipation. Abstract:  Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases. Several studies have been carried out on the treatment of symptoms associated with GERD. The present study aimed to compare the effect of Psyllium seed and oral omeprazole on GERD in patients with functional constipation. In this trial, 132 patients were divided into 2 groups. The impact of omeprazole and Psyllium seed on the treatment and recurrence of GERD was studied. Among the patients, the rate of response to treatment was 89.2% (n = 58) in the Psyllium seed group, while in omeprazole group, it was 94% (n = 63; P = .31). The recurrence rates of Psyllium seed and omeprazole groups were 24.1% (n =14) and 69.8% (n = 44), respectively ( P

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19:50

This candidate for Florida governor is the only one taking money from Big Sugar despite algae bloom controversy "IndyWatch Feed Health"

(Note from Erin: Ive written about how both sides have taken money from Big $ugar in the past. However, this man takes the cake. He should be considered a criminal.) Over the last couple of weeks, weve been pointing out the part that Big Sugar has played in whats happening to the ecosystem in Florida. And []

The post This candidate for Florida governor is the only one taking money from Big Sugar despite algae bloom controversy appeared first on Health Nut News.

19:49

Adding psyllium fiber resulted in reductions in low-density lipoprotein-cholesterol equivalent to doubling the statin dose. "IndyWatch Feed Health"

PMID:  Am J Cardiol. 2018 Jul 4. Epub 2018 Jul 4. PMID: 30078477 Abstract Title:  Meta-Analysis of Usefulness of Psyllium Fiber as Adjuvant Antilipid Therapy to Enhance Cholesterol Lowering Efficacy of Statins. Abstract:  Statins are usually well-tolerated drugs with a clear dose-dependent efficacy. However, manifestation of statin's side effects also bears a direct relation to higher doses necessary to achieve high impact cholesterol-lowering effects. Nevertheless, the reliance on statin efficacy alone has often left dietary intervention underutilized even though studies have shown a reduction in serum cholesterol levels when dietary fiber intake is increased. In this meta-analysis, we investigated whether the concomitant use of psyllium, a gel-forming viscous soluble fiber, would cause further overall cholesterol lowering in subjects already receiving statins. A systematic review of the medical literature was performed and identified three randomized, controlled clinical studies that evaluated the cholesterol lowering efficacy of statins when given concomitantly with psyllium as a fiber supplement. The duration of the studies ranged from 4 weeks to 12 weeks. The objective of the meta-analysis was to estimate the overall effect of psyllium plus statin versus statin alone. The results of the meta-analysis showed a clinically and statistically significant (p=0.001) cholesterol lowering advantage for psyllium plus statin combination treatment over a statin alone. Adding psyllium fiber resulted in reductions in low-density lipoprotein-cholesterol equivalent to doubling the statin dose. In conclusion, the data support that psyllium fiber taken before meals adds to the efficacy of statins, providing an easy to implement dietary intervention for those who cannot tolerate side effects associated with higher-dose statins.

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19:42

Drinking Out of a Glass Water Bottle Offers These Uniquely Overlooked Health Benefits "IndyWatch Feed Health"

 

glass jar water benefits tequila

Mason jars provide a healthier vessel for whatever you happen to be drinking. Photo via Replay Lincoln Park/Chicago

 

 

19:39

15 Year Old French Girls Descent into Hell After Gardasil Vaccine Wheelchair Bound and Paralyzed "IndyWatch Feed Health"

MarieOcane-FB

Marie Ocane photo prior to being injected with the Gardasil vaccines.

Gardasil in France: Marie-Ocane Bourguignons Experience

by SaneVax, Inc.
Story submitted by her parents

MarieOcanes parents, Jean-Jacques and Yveline Bourguignon, granted permission for their daughters story to be published hoping they can help people realize there are potential risks involved with HPV vaccinations. They do not want anyone else to go through what they have experienced without knowing of the possibility in advance.

Jean-Jacques and Yveline say Ocane was a girl full of joy, health, and laughter before her 15th birthday. They affectionately called her their little pearl. She never had to visit the doctor for an illness. That is until her life was turned upside-down because of trust. This is her story.

Ocane was 15 years old when she went to her family doctor to get a medical certificate for dancing with a friend. The doctor suggested Gardasil for cervical cancer prevention. Her parents trusted their family doctor and consented to the vaccination. They did not realize this decision would set off a chain of events that would make Dantes Inferno look like a picnic.

In 2010, Marie-Ocane Bourguignon received two injections of Gardasil; the first on October 11th and the second on December 13th. Two weeks after the first injection, she experienced sensory and motor problems in her upper limbs before spontaneously and gradually regressing over a two week period. Her parents thought the tingling in her arms and loss of balance were simply a normal part of adolescence.

Two months later, after the second injection, she vomited and suffered from severe dizziness. Three months after the second injection, on the 13th of March 2011, MarieOcane was hospitalized at Centre Hospitalier de Dax for deterioration in her general health, cerebral-vestibular disturbances and sensory-motor impairment (ataxia-an inability to coordinate voluntary muscular movements, and vertigo).

On March 15, 2011, an MRI of...

19:27

15 Year Old French Girls Descent into Hell After Gardasil Vaccine Wheelchair Bound and Paralyzed "IndyWatch Feed Health"

MarieOcane-FB

Marie Ocane photo prior to being injected with the Gardasil vaccines.

Gardasil in France: Marie-Ocane Bourguignons Experience

by SaneVax, Inc.
Story submitted by her parents

MarieOcanes parents, Jean-Jacques and Yveline Bourguignon, granted permission for their daughters story to be published hoping they can help people realize there are potential risks involved with HPV vaccinations. They do not want anyone else to go through what they have experienced without knowing of the possibility in advance.

Jean-Jacques and Yveline say Ocane was a girl full of joy, health, and laughter before her 15th birthday. They affectionately called her their little pearl. She never had to visit the doctor for an illness. That is until her life was turned upside-down because of trust. This is her story.

Ocane was 15 years old when she went to her family doctor to get a medical certificate for dancing with a friend. The doctor suggested Gardasil for cervical cancer prevention. Her parents trusted their family doctor and consented to the vaccination. They did not realize this decision would set off a chain of events that would make Dantes Inferno look like a picnic.

In 2010, Marie-Ocane Bourguignon received two injections of Gardasil; the first on October 11th and the second on December 13th. Two weeks after the first injection, she experienced sensory and motor problems in her upper limbs before spontaneously and gradually regressing over a two week period. Her parents thought the tingling in her arms and loss of balance were simply a normal part of adolescence.

Two months later, after the second injection, she vomited and suffered from severe dizziness. Three months after the second injection, on the 13th of March 2011, MarieOcane was hospitalized at Centre Hospitalier de Dax for deterioration in her general health, cerebral-vestibular disturbances and sensory-motor impairment (ataxia-an inability to coordinate voluntary muscular movements, and vertigo).

On March 15, 2011, an MRI of he...

19:05

The Attack On Homeopathy And Your Right To Choose "IndyWatch Feed Health"

By Rosanne Lindsay, ND

The extinction of homeopathic practitioners, desired by many, has not occurred yet, because of their tenacity and creative efforts to spread their knowledge, and also because homeopathy is an open code science accessible to scholars, wise men and women, who work to deepen the knowledge of homeopathy. Felipe Cardenas Tamara, homeopath

Homeopathic pills in vials

On December 18, 2017, the...

18:45

Brazil Court Suspends Glyphosate; What About Doing That, EPA & FDA? "IndyWatch Feed Health"

Brazil Court Suspends Glyphosate; What About Doing That, EPA & FDA?

By Catherine J. Frompovich

The international news agency Reuters reported August 6, 2018,

A Brazilian judge has suspended the use of products containing the agrochemical glyphosate, a widely employed herbicide for soy and other crops in the country, according to legal filings. (Source)

Why would a judge in Brazil take such action, when regulatory officials in the USA think glyphosate is harmless?  Probably because Monsanto and Bayer lobbyists cant get near Brazilian judges?

CNBC reports the same.

https://www.cnbc.com/2018/08/07/reuters-america-update-1-brazil-judge-suspends-use-of-agrochemical-glyphosate.html

Nasdaq, too!

...

18:00

Cops Called to Take Down a Kids Lending Library "IndyWatch Feed Health"

Cops Called to Take Down a Kid's Lending Library

By Heather CallaghanEditor

Were fairly certain that Winston Smith of 1984 had more freedom to curl up with a good book than the kids at Point Pleasant Boro, New Jersey.

Nothing says freedom like having police show up to swat the sharing of ideas and banish the written word.

Thats quite literally what happened recently to Grace and Peter Hagemeyer when they erected a small book case at the end of their driveway. Despite hundreds of these things popping up all over the country, police are starting to crack down on them at the behest of city code enforcers. The police and city code enforcers always say that theres one vague, anonymous complaint that  by Jove!  they must investigate immediately.

Police showed up barely a week after the Hagemeyers placed their mailbox library and ordered it be immediately dismantled, because. there was an alleged complaint.  Unlike when theres an actual crime taking place, police showed up the day of the complaint to fulf...

17:29

What is Triticale and Should You Be Eating It? "IndyWatch Feed Health"

triticaleWheat. One of the worlds oldest and its most grown and consumed staple until recently. Not only does wheat come in many shapes and sizes, including older relatives like spelt, einkorn, and kamut, it also comes in many modern cultivars and crosses hard red, soft white, and a curious grain called triticale. 

The post What is Triticale and Should You Be Eating It? appeared first on The Healthy Home Economist.

16:44

4 Ways to Keep From Losing Your Eyesight (Cataracts) "IndyWatch Feed Health"

The human eye is uniquely equipped to stay young in appearance and health late into life (thanks to the heightened expression of the enzyme telomerase) but not without good nutrition!

The gradual clouding of the lens inside of the eye which leads to a decrease in vision even blindness is called a cataract. It is believed to be an inevitable part of aging, but it has clearly modifiable risk factors and natural interventions that can be used to slow and even reverse its progression, such as:

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15:56

AMI Smart Meter DEFEAT At New Mexico Public Regulation Commission "IndyWatch Feed Health"

AMI Smart Meter DEFEAT At New Mexico Public Regulation Commission

By Catherine J. Frompovich

Whoever would even have guessed a state public utility commission would reject the New World Orders and the UNs Agendas 21 and 2030 smart agenda for asserting and implementing global control mechanisms by deliberately DISAPPROVING a utility companys proposal to retrofit AMI Smart Meters on to its customers electric service?  AMI Smart Meters are an integral link in the coming Internet of Things, smart cities, and possibly other control mechanisms.

Well, there is relief for many residents of the State of New Mexico regarding their not having to suffer the forced retrofitting, non-ionizing radiation and non-thermal adverse health effects of  AMI Smart Meters, also now being called digital meters due to the negative connotations of the term AMI Smart Meter.

The New Mexico Public Regulation Commission did their due diligence and acted responsibly in the interests of NM citizens and the Precautionary Principle.

I congratulate them heartily, and wish other states regulatory commissions had such integrity.

Here is the 121-page Decision of the...

15:22

CBS: Pediatrician charged with sexually abusing dozens of children, including a 2-week-old infant "IndyWatch Feed Health"

(Note from Erin: We are so sorry for all these kids and their families. Our hearts go out to them.) This spring Dr. Johnnie Barto, 70, a Pennsylvania pediatrician, was charged with abusing a 12-year-old patient. However, at the end of July, he was charged with sexually abusing an additional 29 children over the course of []

The post CBS: Pediatrician charged with sexually abusing dozens of children, including a 2-week-old infant appeared first on Health Nut News.

15:08

Women suffers from mystery illness for 10 years then two men make horrifying discovery "IndyWatch Feed Health"

By Emilyn Gil Health and wellness is an extensive subject. With frequent discoveries, new research, and updated technology we are constantly learning more and more about treatments, medical practices, and how the human body works. Over the years weve come incredibly far and accomplished things never before thought possible. Yet, even with all the advancements of []

The post Women suffers from mystery illness for 10 years then two men make horrifying discovery appeared first on Health Nut News.

15:06

The proven dangers of microwaves "IndyWatch Feed Health"

Extracted from NEXUS Magazine, Volume 2, #25 (April-May 95). Originally printed from the April 1994 edition of Acres, USA. Back in May of 1989, after Tom Valentine first moved to St Paul, Minnesota, he heard on the car radio a short announcement that bolted him upright in the drivers seat. The announcement was sponsored by []

The post The proven dangers of microwaves appeared first on Health Nut News.

14:14

Pet Vaccines Market May Topple $9 Billion "IndyWatch Feed Health"

Who needs people? Thats most likely what big drug companies are finally realizing after all these years. Pet vaccines are big business. If youve ever taken your pet to a veterinarian, then you know that...

The post Pet Vaccines Market May Topple $9 Billion appeared first on Vaxxter.

14:00

A 2015 PNAS paper is six pages long. Its correction is four pages long. "IndyWatch Feed Health"

Sometimes, corrections are so extensive, they can only be called one thing: Mega-corrections. Recently, the Proceedings of the National Academy of Sciences (PNAS) issued a four-page correction notice to a paper about a compound that appeared to reduce the chances a cancer will recur. The notice describes figure duplication, problems with error bars and figure Continue reading A 2015 PNAS paper is six pages long. Its correction is four pages long.

12:45

Italian Senate Repeals Vaccine Mandates "IndyWatch Feed Health"

The Italian people have spoken (voted in politicians who promised to end the mandates) and they said, "ciao!" to vaccine mandates. Note how parents and citizens who protested mandatory vaccination are called "anti-establishment." Pay careful attention to the last line...

12:02

Judge Rules No More Drugging Migrant Children Without Consent "IndyWatch Feed Health"

From MSN News: A federal judge on Monday found that U.S. government officials have been giving psychotropic medication to migrant children at a Texas facility without first seeking the consent of their parents or guardians, in violation of state child welfare laws.

U.S. District Judge Dolly Gee in Los Angeles ordered the Trump administration to obtain consent or a court order before administering any psychotropic medications to migrant children, except in cases of dire emergencies. She also ordered that the government move all children out of a Texas facility, Shiloh Residential Treatment Center in Manvel, except for children deemed by a licensed professional to pose a risk of harm to themselves or others.

Article 

12:01

What Is It Like to Be Sectioned? "IndyWatch Feed Health"

From ShortList: I asked to go out for a cigarette but was told that if I tried to leave I would be sectioned against my will. I argued that I was there of my own free will and could leave at any time. I was sectioned, Gary says. When a person is detained, despite a code of practice that stipulates otherwise, they can have very little control over what happens to them. Each time I have been sectioned, I felt trapped, powerless and unsafe, Gary says.

There is little communication by staff other than at medication times. There is little access to fresh air. Restraints by staff and attacks by other patients are commonplace. Coercion to take medication. No one tells me how to appeal my section. My family dont want to visit as they dont feel safe on the ward either. Gary says he has felt humiliated, powerless and violated when sectioned, on occasions feeling like some kind of non-human. He also notes there is little in the way of follow up care. After months of being locked away, Im suddenly free and alone at home.'

Article 

11:59

Vaccines as Alternatives to Antibiotics for Food Producing Animals. Part 1: Challenges and Needs "IndyWatch Feed Health"

Note: This article from the journal Veterinary Research provides a rare glimpse (pardon the meat pun) into what vaccine discussions can look like when the target recipients aren't children. Would love to hear David Kirby's take on this, since his...

10:31

Gardasil in France: Marie-Ocane Bourguignons Experience "IndyWatch Feed Health"

Story submitted by her parents

Before Gardasil Injections

MarieOcanes parents, Jean-Jacques and Yveline Bourguignon, granted permission for their daughters story to be published hoping they can help people realize there are potential risks involved with HPV vaccinations. They do not want anyone else to go through what they have experienced without knowing of the possibility in advance.

Jean-Jacques and Yveline say Ocane was a girl full of joy, health, and laughter before her 15th birthday. They affectionately called her their little pearl. She never had to visit the doctor for an illness. That is until her life was turned upside-down because of trust. This is her story.

Ocane was 15 years old when she went to her family doctor to get a medical certificate for dancing with a friend. The doctor suggested Gardasil for cervical cancer prevention. Her parents trusted their family doctor and consented to the vaccination. They did not realize this decision would set off a chain of events that would make Dantes Inferno look like a picnic.

In 2010, Marie-Ocane Bourguignon received two injections of Gardasil; the first on October 11th and the second on December 13th. Two weeks after the first injection, she experienced sensory and motor problems in her upper limb...

07:00

Game Changer of the Year: Carole Baggerly "IndyWatch Feed Health"

Congratulations to yesterdays winners: Georgene from Sandia & Kathy from Dunedin! Click here to enter our giveaway for your chance to win!

By Dr. Mercola

Each year during the anniversary week of Mercola.com, we recognize a Game Changer, someone whose work stands as a great service to humanity by making a significant contribution to improving people's health.

Previous recipients include Dr. Fred A. Kummerow for his life's work on trans fats, Thomas Seyfried, Ph.D., for his advancement of cancer as a metabolic disease, and Dr. Lee Cowden for his advancement of integrative medicine through the creation of the Academy of Comprehensive Integrative Medicine.

This year, we present the Game Changer Award to Carole Baggerly, director and founder of GrassrootsHealth, a nonprofit public health research organization dedicated to moving public health messages regarding vitamin D from research into practice.

"Our tag line, 'Moving Research into Practice,' [came about] because the more I got into it, the more I realized that the clinical research is there for many health conditions, yet the implementation process wasn't happening.

You cannot expect a new success story to be implemented for somewhere between 15 and 25 years. So, we work not only on the science but on the methodology. That's really important," Baggerly says.

"The biggest problem with the implementation of vitamin D right now is the methodology used to analyze the data. Almost every time you see a report that comes out that says there was no effect, they analyzed the data by dosage.

Analyzing by dosage is really targeted to give you no result. If you analyze it properly, by serum level, not by intake, you get interesting results. Our first paper, published in 2011, showed the dose response relationship. You can easily see that two people taking the same dose (e.g., 4,000 IU/day) could have very different results. That's why testing and reporting by achieved level is so important."

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Mercola.com Is Now Available in 10 Languages! "IndyWatch Feed Health"

Congratulations to yesterdays winners: Georgene from Sandia & Kathy from Dunedin! Click here to enter our giveaway for your chance to win!

By Dr. Mercola

Inspiring you to live a better, healthier life is our goal here at Mercola.com, and it's a message that crosses borders and reaches virtually every corner of the globe. That's why we're now sharing our message to take control of your health in two new languages, Polish and German, bringing the total to 10 languages worldwide:

English

Spanish

French

Russian

Portuguese

Korean

Japanese

Chinese

Polish

German

In the U.S., Mercola.com is the No. 1 most visited natural health website, and worldwide it's one the most visited health websites in any health category. Now, if you have friends or family who live in a different country, you can share your favorite health articles with ease. We've also expanded our health activism on an international level, working to support local organic agriculture and fight the spread of genetically engineered (GE) crops in Latin America and Mexico via our partnerships with:

  • ...

03:42

A review of the preventive and therapeutic potential of vitamin C in mental disorders. "IndyWatch Feed Health"

PMID:  Curr Med Sci. 2018 Feb ;38(1):1-10. Epub 2018 Mar 15. PMID: 30074145 Abstract Title:  Preventive and Therapeutic Potential of Vitamin C in Mental Disorders. Abstract:  In this review, we summarize the involvement of vitamin C in mental disorders by presenting available evidence on its pharmacological effects in animal models as well as in clinical studies. Vitamin C, especially its reduced form, has gained interest for its multiple functions in various tissues and organs, including central nervous system (CNS). Vitamin C protects the neuron against oxidative stress, alleviates inflammation, regulates the neurotransmission, affects neuronal development and controls epigenetic function. All of these processes are closely associated with psychopathology. In the past few decades, scientists have revealed that the deficiency of vitamin C may lead to motor deficit, cognitive impairment and aberrant behaviors, whereas supplement of vitamin C has a potential preventive and therapeutic effect on mental illness, such as major depressive disorder (MDD), schizophrenia, anxiety and Alzheimer's disease (AD). Although several studies support a possible role of vitamin C against mental disorders, more researches are essential to accelerate the knowledge and investigate the mechanism in this field.

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03:36

Lycium barbarum polysaccharide is an effective and safe hepatoprotective agent against alcoholic liver disease. "IndyWatch Feed Health"

PMID:  Mol Nutr Food Res. 2018 Jul ;62(13):e1800144. Epub 2018 Jun 10. PMID: 29797417 Abstract Title:  Lycium barbarum Polysaccharide Supplementation Improves Alcoholic Liver Injury in Female Mice by Inhibiting Stearoyl-CoA Desaturase 1. Abstract:  SCOPE: Lycium barbarum polysaccharide (LBP) is a water fraction of wolfberry, which has been demonstrated to possess a hepatoprotective effect in several liver disease models. However, the anti-alcoholic liver disease (anti-ALD) mechanism of LBP has not been investigated thoroughly. Its protective effects on both male and femal mice are investigated in the current study.METHODS AND RESULTS: A chronic ethanol-fed ALD in vivo model is applied to study the effect of LBP in both male and female mice. It is observed that ethanol causes more severe liver injury in female than male mice, and the ameliorative effects of LBP are also more significant in female mice, which are impaired after complete bilateral oophorectomy. The hepatic SCD1 expression is found to be positively correlated with the severity of the liver damage and the main mediator of LBP inducer of protection. The AMPK-CPT pathway is also activated by LBP to rebalance the dysregulated lipid metabolism during ALD development. By using concurrent sodium palmitate and an ethanol-induced in vitro cell damage model in AML-12 cell line, it is characterized that LBP directly interacts with ER instead of ER to activate the SCD1-AMPK-CPT pathway.CONCLUSIONS: LBP is an effective and safe hepatoprotective agent against ALD primarily through the SCD1-AMPK-CPT pathway after ER agonist.

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03:25

Asiatic acid may be a valuable agent for the therapeutic intervention of human hepatomas. "IndyWatch Feed Health"

PMID:  Cancer Lett. 2002 Dec 1 ;186(1):83-91. PMID: 12183079 Abstract Title:  Asiatic acid, a triterpene, induces apoptosis through intracellular Ca2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Abstract:  Asiatic acid (AA), a triterpene, decreased viability and induced apoptosis of HepG2 human hepatoma cells in a dose-dependent manner. AA also markedly increased intracellular Ca(2+) level, which was blocked by TMB-8 and dantrolene, intracellular Ca(2+) release blockers, but not by EGTA, an extracellular Ca(2+) chelator. Moreover, AA-induced apoptosis was significantly suppressed by treatment with TMB-8 and dantrolene, suggesting that intracellular Ca(2+) release may play an essential role in the AA-induced apoptosis. In addition, AA profoundly increased protein level of p53, which was also inhibited by BAPTA/AM, an intracellular Ca(2+) chelator, TMB-8 and dantrolene. Treatment with A23187, a Ca(2+) ionophore, or thapsigargin, a Ca(2+)-ATPase inhibitor, alone enhanced p53 nuclear accumulation, indicating that p53 accumulation is dependent on intracellular Ca(2+) increase. Furthermore, the viability of Hep3B, p53-null cells, was much higher than that of HepG2, p53-wild type cells, when treated with AA. Taken together, these results suggest that AA induced apoptosis through increased intracellular Ca(2+), which, in turn, enhanced p53 expression in HepG2 cells. These results further suggest that AA may be a valuable agent for the therapeutic intervention of human hepatomas.

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03:19

Asiatic acid induces apoptosis and cell cycle arrest in human breast cancer cells. "IndyWatch Feed Health"

PMID:  J Pharmacol Exp Ther. 2005 Apr ;313(1):333-44. Epub 2004 Dec 30. PMID: 15626723 Abstract Title:  Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. Abstract:  This study first investigates the anticancer effect of asiatic acid in two human breast cancer cell lines, MCF-7 and MDA-MB-231. Asiatic acid exhibited effective cell growth inhibition by inducing cancer cells to undergo S-G2/M phase arrest and apoptosis. Blockade of cell cycle was associated with increased p21/WAF1 levels and reduced amounts of cyclinB1, cyclinA, Cdc2, and Cdc25C in a p53-independent manner. Asiatic acid also reduced Cdc2 function by increasing the association of p21/WAF1/Cdc2 complex and the level of inactivated phospho-Cdc2 and phospho-Cdc25C. Asiatic acid treatment triggered the mitochondrial apoptotic pathway indicated by changing Bax/Bcl-2 ratios, cytochrome c release, and caspase-9 activation, but it did not act on Fas/Fas ligand pathways and the activation of caspase-8. We also found that mitogen-activated protein kinases (MAPKs), extracellular signal-regulated kinase (ERK1/2), and p38, but not c-Jun NH2-terminal kinase (JNK), are critical mediators in asiatic acid-induced cell growth inhibition. U0126 [1,4-diamino-2,3-dicyano-1,4-bis(2-aminophenylthio)butadiene] or SB203580 [4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole], specific inhibitors of mitogen-activated protein kinase kinase and p38 kinase activities, significantly decreased or delayed apoptosis. Asiatic acid was likely to confine the breast cancer cells in the S-G2/M phase mainly through the p38 pathway, because both SB203580 and p38 small interfering RNA (siRNA) inhibition significantly attenuated the accumulation of inactive phospho-Cdc2 and phospho-Cdc25C proteins and the cell numbers of S-G2/M phase. Moreover, U0126 and ERK siRNA inhibition completely suppressed asiatic acid-induced Bcl-2 phosphorylation and Bax up-regulation, and caspase-9 activation. Together, these results imply a critical role for ERK1/2 and p38 but not JNK, p53, and Fas/Fas ligand in asiatic acid-induced S-G2/M arrest and apoptosis of human breast cancer cells.

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03:03

Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. "IndyWatch Feed Health"

PMID:  J Med Invest. 2005 Feb ;52(1-2):65-73. PMID: 15751275 Abstract Title:  Inhibitory effects of asiatic acid and CPT-11 on growth of HT-29 cells. Abstract:  Asiatic acid is a pentacyclic triterpene contained in medicinal plants. The cytotoxic effect of this compound and its augmentative effect on the anticancer drug irinotecan hydrochloride (CPT-11) were investigated in the human colon adenocarcinoma cell line HT-29. Asiatic acid dose-dependently showed cytotoxicity in HT-29 cells. DNA fragmentation, annexin-positive apoptotic cells, and caspase-3 activation were observed in a dose-dependent manner. A caspase-3 inhibitor suppressed the DNA ladder formation in a concentration-dependent manner. Bcl-2 and Bcl-XL proteins were decreased by asiatic acid treatment. These results indicate that asiatic acid induced apoptosis in HT-29 cells via caspase-3 activation. Cytotoxic effects of combined treatment with CPT-11 and asiatic acid on HT-29 cells were further examined. Simultaneous treatment or sequential exposure first to asiatic acid and then to CPT-11 showed an additive effect. Synergism was observed when cells were first exposed to CPT-11 and then to asiatic acid. These results suggest that asiatic acid can be used as an agent for increasing sensitivity of colon cancer cells to treatment with CPT-11 or as an agent for reducing adverse effects of CPT-11.

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02:51

Our Cellphone Addiction Is Turning Wireless Tech Into an Invisible Weapon Thats Destroying Wildlife "IndyWatch Feed Health"

Our Cellphone Addiction Is Turning Wireless Tech Into an Invisible Weapon Thats Destroying Wildlife

By Reynard Loki, Independent Media Institute

There is growing evidence that our addiction to cellphones could be impacting brain functionality and be the cause of stress, anxiety, insomnia and a lack of attention and focus. Now a new report has found that were not the only living things to be affected by our increasing dependence on wireless technology. Mammals, birds, insects and even plants are likely being harmed by the electromagnetic radiation (EMR) emanating from Wi-Fi, cellphone towers, broadcast transmitters and power lines, according to a new analysis of 97 peer-reviewed studies conducted by EKLIPSE, a biodiversity and ecosystem project funded by the European Union.

The researchers said that evidence is accumulating that mammals (e.g., bats and mice) have a magnetic sense that is affected by radio-frequency-modulated electromagnetic fields (RF-EMR). Birds in particular may be highly susceptible. The researchers found that even weak magnetic fields in the radio frequency range can disrupt birds magnetoreception, their ability to use the Earths magnetic fields to orient themselves and find their way home.

...

02:42

Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice. "IndyWatch Feed Health"

PMID:  J Pharm Pharmacol. 2006 Feb ;58(2):227-33. PMID: 16451751 Abstract Title:  Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice. Abstract:  Asiatic acid (AA) is one of the triterpenoid components of Terminalia catappa L., which has antioxidative, anti-inflammatory and hepatoprotective activity. This research focused on the mitochondrial protection of AA against acute liver injury induced by lipopolysaccharide (LPS) and D-galactosamine (D-GalN) in mice. It was found that pretreatment with 25, 50 or 100 mg kg(-1) AA significantly blocked the LPS + D-GalN-induced increase in both serum aspartate aminotransferase (sAST) and serum alanine aminotransferase (sALT) levels, which was confirmed by ultrastructural observation under an electron microscope, showing improved nuclear condensation, ameliorated mitochondrion proliferation and less lipid deposition. Meanwhile, different doses of AA could decrease both the transcription and the translation level of voltage-dependent anion channels (VDACs), the most important mitochondrial PTP component protein, and block the translocation of cytochrome c from mitochondria to cytosol. On the other hand, pre-incubation with 25, 50 and 100 microg mL(-1) AA inhibited the Ca(2+)-induced mitochondrial permeability transition (MPT), including mitochondrial swelling, membrane potential dissipation and releasing of matrix Ca(2+) in liver mitochondria separated from normal mice, indicating the direct role of AA on mitochondria. Collectively, the above data suggest that AA could protect liver from damage and the mechanism might be related to up-regulating mitochondrial VDACs and inhibiting the process of MPT.

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02:38

Glioblastoma cell death was induced by asiatic acid. "IndyWatch Feed Health"

PMID:  Cell Biol Toxicol. 2006 Nov ;22(6):393-408. Epub 2006 Aug 1. PMID: 16897440 Abstract Title:  Glioblastoma cell death induced by asiatic acid. Abstract:  Asiatic acid (AA), a triterpene, is known to be cytotoxic to several tumor cell lines. AA induces dose- and time-dependent cell death in U-87 MG human glioblastoma. This cell death occurs via both apoptosis and necrosis. The effect of AA may be cell type-specific as AA-induced cell death was mainly apoptotic in colon cancer RKO cells. AA-induced glioblastoma cell death is associated with decreased mitochondrial membrane potential, activation of caspase-9 and -3, and increased intracellular free Ca2+. Although treatment of glioblastoma cells with the caspase inhibitor zVAD-fmk completely abolished AA-induced caspase activation, it did not significantly block AA-induced cell death. AA-induced cell death was significantly prevented by an intracellular Ca2+ inhibitor, BAPTA/AM. Taken together, these results indicate that AA induces cell death by both apoptosis and necrosis, with Ca2+-mediated necrotic cell death predominating.

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02:32

These results suggest that asiatic acid inhibited of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions. "IndyWatch Feed Health"

PMID:  Int Immunopharmacol. 2008 Mar ;8(3):431-41. Epub 2007 Dec 3. PMID: 18279797 Abstract Title:  Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-kappa B inactivation in RAW 264.7 macrophages: possible involvement of the IKK and MAPK pathways. Abstract:  In the present study, we investigated the effect of asiatic acid (the aglycon of asiaticoside) and asiaticoside isolated from the leaves of Centella asiatica (Umbelliferae) on LPS-induced NO and PGE(2) production in RAW 264.7 macrophage cells. Asiatic acid more potently inhibited LPS-induced NO and PGE(2) production than asiaticoside. Consistent with these observations, the protein and mRNA expression levels of inducible iNOS and COX-2 enzymes were inhibited by asiatic acid in a concentration-dependent manner. In addition, asiatic acid dose-dependently reduced the production of IL-6, IL-1 beta and TNF-alpha in LPS-stimulated RAW 264.7 macrophage cells. Furthermore, asiatic acid inhibited the NF-kappaB activation induced by LPS, and this was associated with the abrogation of I kappa B-alpha degradation and with subsequent decreases in nuclear p65 and p50 protein levels. Moreover, the phosphorylations of IKK, p38, ERK1/2, and JNK in LPS-stimulated RAW 264.7 cells were suppressed by asiatic acid in a dose-dependent manner. These results suggest that the anti-inflammatory properties of asiatic acid might be the results from the inhibition of iNOS, COX-2, IL-6, IL-1 beta, and TNF-alpha expressions through the down-regulation of NF-kappaB activation via suppression of IKK and MAP kinase (p38, ERK1/2, and JNK) phosphorylation in RAW 264.7 cells.

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02:19

A review of cannabinoid pharmacology and therapy in gut disorders. "IndyWatch Feed Health"

PMID:  Biochem Pharmacol. 2018 Aug 1. Epub 2018 Aug 1. PMID: 30076849 Abstract Title:  Cannabinoid pharmacology and therapy in gut disorders. Abstract:  Cannabis sp and their products (marijuana, hashish...), in addition to their recreational, industrial and other uses, have a long history for their use as a remedy for symptoms related with gastrointestinal diseases. After many reports suggesting these beneficial effects, it was not surprising to discover that the gastrointestinal tract expresses endogenous cannabinoids, their receptors, and enzymes for their synthesis and degradation, comprising the so-called endocannabinoid system. This system participates in the control of tissue homeostasis and important intestinal functions like motor and sensory activity, nausea, emesis, the maintenance of the epithelial barrier integrity, and the correct cellular microenvironment. Thus, different cannabinoid-related pharmacological agents may be useful to treat the main digestive pathologies. To name a few examples, in irritable bowel syndrome they may normalize dysmotility and reduce pain, in inflammatory bowel disease they may decrease inflammation, and in colorectal cancer, apart from alleviating some symptoms, they may play a role in the regulation of the cell niche. This review summarizes the main recent findings on the role of cannabinoid receptors, their synthetic or natural ligands and their metabolizing enzymes in normal gastrointestinal function and in disorders including irritable bowel syndrome, inflammatory bowel disease, colon cancer and gastrointestinal chemotherapy-induced adverse effects (nausea/vomiting, constipation, diarrhea).

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02:11

A review of the anti-tumoural actions of cannabinoids. "IndyWatch Feed Health"

PMID:  Br J Pharmacol. 2018 Jul 17. Epub 2018 Jul 17. PMID: 30019449 Abstract Title:  Anti-tumoural actions of cannabinoids. Abstract:  The endocannabinoid system has emerged as a considerable target for the treatment of diverse diseases. In addition to the well-established palliative effects of cannabinoids in cancer therapy, phytocannabinoids, synthetic cannabinoid compounds as well as inhibitors of endocannabinoid degradation have attracted attention as possible systemic anticancer drugs. As a matter of fact, accumulating data from preclinical studies suggest cannabinoids elicit effects on different levels of cancer progression, comprising inhibition of proliferation, neovascularisation, invasion and chemoresistance, induction of apoptosis and autophagy as well as enhancement of tumour immune surveillance. Although the clinical use of cannabinoid receptor ligands is limited by their psychoactivity, nonpsychoactive compounds, such as cannabidiol, have gained attention due to preclinically established anticancer properties and a favourable risk-to-benefit profile. Thus, cannabinoids may complement the currently used collection of chemotherapeutics, as a broadly diversified option for cancer treatment, while counteracting some of their severe side effects.

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01:08

The aim of this review is to provide an overview of the potential use of cannabinoids in the treatment of glaucoma. "IndyWatch Feed Health"

PMID:  Ugeskr Laeger. 2018 Jul 16 ;180(29). PMID: 30020072 Abstract Title:  [Should ophtalmologists recommend medical cannabis to patients with glaucoma?] Abstract:  Cannabis has been widely used for various medical purposes since before year 2000 BC. Its effects are mediated by cannabinoids and stimulation of mainly G-protein coupled cannabinoid receptors. In 1971, subjects who smoked marihuana, showed a decrease in the intraocular pressure. Later investigations additionally revealed a neuroprotective effect of both-9-tetrahydrocannabinol and cannabidiol (CBD). Furthermore, CBD was found to promote neurogenesis. The aim of this review is to provide an overview of the potential use of cannabinoids in the treatment of glaucoma.

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01:05

Cannabidiol does not display drug abuse potential in mice behavior. "IndyWatch Feed Health"

PMID:  Acta Pharmacol Sin. 2018 Jul 18. Epub 2018 Jul 18. PMID: 30022153 Abstract Title:  Cannabidiol does not display drug abuse potential in mice behavior. Abstract:  Recent evidence suggests that cannabidiol (CBD) may be useful for the treatment of different neuropsychiatric disorders. However, some controversy regarding its profile as a drug of abuse hampers the further development of basic and clinical studies. In this study, the behavioral profile of CBD as a potential drug of abuse was evaluated in C57BL/6J mice. Reinforcing properties of CBD (15, 30, and 60mg/kg; i.p.) were assessed using the conditioned place preference (CPP) paradigm. Spontaneous withdrawal symptoms and motor activity in the open field were examined 12h after the last CBD administration (30mg/kg/12h, i.p., 6 days). CBD plasma concentrations were measured at 2, 4, 8, 12,and 24h after the administration of CBD (30mg/kg, i.p.). Furthermore, an oral CBD self-administration paradigm (50mg/kg; CBD water-soluble 1.2mg/mL) was performed to evaluate whether this drug produced any effects on motivation compared with a non-reinforcing substance (water). We foundthat CBD failed to induce CPP, withdrawal symptoms, or altered motor behavior 12h after its administration. At that time, only traces of CBD were detected, ensuring that the lack of alterations in somatic signs and locomotor activity was not due to residual drug in plasma. Interestingly, mice displayed similar motivation and consumption of CBD and water. Taken together, these results show that CBD lacks activity as a drug of abuse and should stimulate the development of the basic and clinical studies needed to elucidate its potential therapeutic use for the treatment of neuropsychiatric anddrug use disorders.

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00:44

Asiatic acid is neuroprotective in a mouse model of focal cerebral ischemia. "IndyWatch Feed Health"

n/a PMID:  J Neurosci Res. 2009 Aug 15 ;87(11):2541-50. PMID: 19382233 Abstract Title:  Asiatic acid, a pentacyclic triterpene from Centella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia. Abstract:  Asiatic acid, a triterpenoid derivative from Centella asiatica, has shown biological effects such as antioxidant, antiinflammatory, and protection against glutamate- or beta-amyloid-induced neurotoxicity. We investigated the neuroprotective effect of asiatic acid in a mouse model of permanent cerebral ischemia. Various doses of asiatic acid (30, 75, or 165 mg/kg) were administered orally at 1 hr pre- and 3, 10, and 20 hr postischemia, and infarct volume and behavioral deficits were evaluated at day 1 or 7 postischemia. IgG (blood-brain barrier integrity) and cytochrome c (apoptosis) immunostaining was carried out at 24 hr postischemia. The effect of asiatic acid on stress-induced cytochrome c release was examined in isolated mitochondrial fractions. Furthermore, its effects on cell viability and mitochondrial membrane potential were studied in HT-22 cells exposed to oxygen-glucose deprivation. Asiatic acid significantly reduced the infarct volume by 60% at day 1 and by 26% at day 7 postischemia and improved neurological outcome at 24 hr postischemia. Our studies also showed that the neuroprotective properties of asiatic acid might be mediated in part through decreased blood-brain barrier permeability and reduction in mitochondrial injury. The present study suggests that asiatic acid may be useful in the treatment of cerebral ischemia.

00:37

THC combined with CBD led to a rapid and highly significant improvement in a patient with Tourette syndrome. "IndyWatch Feed Health"

PMID:  Int J Psychiatry Med. 2018 Jul 30:91217418791455. Epub 2018 Jul 30. PMID: 30058466 Abstract Title:  Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report. Abstract:  Objectives Anecdotal reports and preliminary studies suggest a therapeutic potential of cannabis in Tourette syndrome. We report the case of a female patient suffering from treatment-resistant Tourette syndrome. Methods Guideline-directed antipsychotic treatment with risperidone and aripiprazole as well as pure delta-9-tetrahydrocannabinol had no significant effect on Tourette syndrome symptomatology. Results Following administration of a daily dosage of 10 mg delta-9-tetrahydrocannabinol combined with 20 mg cannabidiol (CBD), the patient showed a rapid and highly significant improvement in the Yale Global Tic Severity Scale. Conclusions It can be speculated whether the beneficial effects may rely on the pharmacological properties of cannabidiol.

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00:23

New Way to Kidnap Children from Their Homes: Pretend to be a Social Worker "IndyWatch Feed Health"

Black woman greeting a solicitor at her front door photo

by Terri LaPoint
Health Impact News

It is the one of the scariest things that a parent can ever experience. There is a knock on the door. Someone says, I am a social worker from Child Protective Services. We got a call and I need to see your children.

It happens every day in every state all across America. Social workers, alone or accompanied by police, show up to homes and to hospital rooms without a court order or warrant. There is no emergency circumstance where a childs life is in danger in the time it would take for them to get a court order or warrant signed by a judge, as provided for in the 4th Amendment to the Constitution of the United States.

As terrifying as this is, what if the person on the doorstep is not even a social worker? What if they are a kidnapper posing as a social worker?

This happened to a mother in New York recently. Ashley Bradley posted her story on Facebook, and the post went viral. If she had not known her rights, she could easily have fallen prey to a scheme to kidnap her 9-month-old baby.

CafeMom writes:

Ashley Bradley had just put her little boy down for a nap on Wednesday afternoon when there was an unexpected knock at her door. The mom from New York wasnt expecting any visitors, which is why the woman on her doorstep caught her off guard.

But when she opened the door, this stranger announced that she was from Child Protective Services and was there to take Bradleys 9-month-old son away.

Bradley describes her reaction on Facebook:

At first I was so mad and hurt I wasnt thinking right but the[n] I realized that she 1. Didnt have a state issued badge, 2. My sons name was spelled wrong on the folder she had in her hand and 3. I have no cps cases so they would not have been coming to my house.

She wisely demanded proof of the womans identity, but the social...

00:17

Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxideinduced oxidative stress and apoptosis. "IndyWatch Feed Health"

PMID:  Mol Med Rep. 2018 Jul 12. Epub 2018 Jul 12. PMID: 30015960 Abstract Title:  Lycium barbarum polysaccharides protect human trophoblast HTR8/SVneo cells from hydrogen peroxideinduced oxidative stress and apoptosis. Abstract:  Pregnancy complications are associated with abnormal cytotrophoblast differentiation and invasion. Hydrogen peroxide (H2O2) is an important mediator of oxidative ischemia/reperfusion stress in the placenta. Lycium barbarum polysaccharides (LBP) have been demonstrated to counteract oxidative free radicals. The effects of LBP in trophoblast HTR8/SVneo cells injured with H2O2 were examined. A cell counting kit8 assay was performed to detect the effect of LBP at different concentrations on the proliferativeability of H2O2 injured trophoblast cells. Flow cytometry was used to determine the levels of reactive oxygen species (ROS), mitochondria membrane potential (MMP) disruption and apoptosis. Superoxide dismutase (SOD) activity and lactate dehydrogenase (LDH) leakage into the supernatant was detected by ultraviolet spectrophotometry. Reverse transcriptionquantitative polymerase chain reaction and western blot analysis were performed to detect the expression of apoptosisassociated factors, including survivin, hypoxia inducible factor 1 (HIF1), Bcl2 apoptosis regulator (Bcl2),Bcl2 associated X apoptosis regulator (Bax). The results revealed that LBP protected the proliferative ability of trophoblast cells injured with H2O2 in a dosedependent manner. LBP inhibited the oxidative stress induced by H2O2, by reducing ROS and LDH levels and increasing SOD activity. Additionally, LBP decreased MMP disruption and cell apoptosis induced by H2O2, by increasing the mRNA and protein expression of survivin, HIF1 and Bcl2 and decreasing Bax expression. Therefore, it was concluded that LBP protected human trophoblast cells from H2O2induced oxidative stress and cell apoptosis via regulation of apoptosisassociated factor expression. It will provide a novel strategy for the treatment of pregnancy complications.

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00:07

Stomach Pain and Diarrhea: Causes & Treatments (Medically Researched) "IndyWatch Feed Health"

Stomach pain and diarrhea can cause a lot of intestinal discomfort, not to mention embarrassment. Acute bouts of abdominal pain and loose, watery stool could be due to viral infections, food poisoning, or indigestion. Other digestive conditions like irritable bowel syndrome, celiac disease, or inflammatory bowel disorders can cause chronic stomach aches and diarrhea.

Severe stomach pain can feel like short, sharp cramps that come and go. Or, the stomach ache could be a dull, constant gnawing feeling in your gut. Sometimes, passing watery stool can help to alleviate the pain in your stomach. Diarrhea could be fatty with bits of mucus in it or you may notice diarrhea with blood.

In some cases you may suffer from burning diarrhea or painful diarrhea especially if you ate spicy foods or when you have chronic diarrhea.

Usually, acute bouts of stomach pain and diarrhea could last a few days if caused by an infection. If you start to have persistent stomach cramping and diarrhea, it is best to visit your doctor.

The symptoms of diarrhea and stomach pain can sometimes help to diagnose the exact cause.

Diarrhea or Burning Diarrhea What Is It?

Diarrhea is described as frequent loose watery stools that you pass frequently with or without pain.

In some cases, especially when having chronic or intense diarrhea, you may feel pain or burning sensation during or after the bowel movements. This is described as burning diarrhea.

Symptoms Related to Stomach Pain and Diarrhea

Cramping aches in your stomach with diarrhea can cause an urgent need to frequently run to the bathroom. As if that wasnt enough, stomach pain and diarrhea can be accompanied with other unpleasant symptoms like:

00:05

New Way to Kidnap Children from Their Homes: Pretend to be a Social Worker "IndyWatch Feed Health"

Black woman greeting a solicitor at her front door photo

by Terri LaPoint
Health Impact News

It is the one of the scariest things that a parent can ever experience. There is a knock on the door. Someone says, I am a social worker from Child Protective Services. We got a call and I need to see your children.

It happens every day in every state all across America. Social workers, alone or accompanied by police, show up to homes and to hospital rooms without a court order or warrant. There is no emergency circumstance where a childs life is in danger in the time it would take for them to get a court order or warrant signed by a judge, as provided for in the 4th Amendment to the Constitution of the United States.

As terrifying as this is, what if the person on the doorstep is not even a social worker? What if they are a kidnapper posing as a social worker?

This happened to a mother in New York recently. Ashley Bradley posted her story on Facebook, and the post went viral. If she had not known her rights, she could easily have fallen prey to a scheme to kidnap her 9-month-old baby.

CafeMom writes:

Ashley Bradley had just put her little boy down for a nap on Wednesday afternoon when there was an unexpected knock at her door. The mom from New York wasnt expecting any visitors, which is why the woman on her doorstep caught her off guard.

But when she opened the door, this stranger announced that she was from Child Protective Services and was there to take Bradleys 9-month-old son away.

Bradley describes her reaction on Facebook:

At first I was so mad and hurt I wasnt thinking right but the[n] I realized that she 1. Didnt have a state issued badge, 2. My sons name was spelled wrong on the folder she had in her hand and 3. I have no cps cases so they would not have been coming to my house.

She wisely demanded...

00:03

Goji polysaccharide attenuates diabetic testicular dysfunction. "IndyWatch Feed Health"

PMID:  Cell Tissue Res. 2018 Aug 2. Epub 2018 Aug 2. PMID: 30073544 Abstract Title:  Lycium barbarum polysaccharide attenuates diabetic testicular dysfunction via inhibition of the PI3K/Akt pathway-mediated abnormal autophagy in male mice. Abstract:  Testicular dysfunction is one of the serious secondary complications in diabetes. Lycium barbarum polysaccharide (LBP) has long been considered to possess a wide range of beneficial properties including antiaging, anticancer and reproductive-enhancing. Abnormal autophagy was reported to play a significant role in accelerating diabetic reproductive injury. However, the autophagy regulation mechanism of LBP on diabetic testicular dysfunction is incompletely understood. We investigate the protective effects of LBP on diabetic testicular dysfunction and its underlying mechanism with different approaches. Protective effects of LBP (40 mg/kg) on testicular functions were assessed through the use of sperm parameters, testosterone levels and hematoxylin and eosin staining. Antioxidant capacity and serum malondialdehyde levels were determined using assay kits. Immune intensity of Beclin-1 and LC3I in testes was detected by immunofluorescence staining. Western blot analysis was used to detect expressions of p-PI3K, Akt, p-Akt, Beclin-1, LC3I and LC3II proteins. Q-PCR was used to evaluate Beclin-1 and LC3I mRNA expressions in testis. Administration of LBP (40 mg/kg) considerably recovered testicular function, obviously improved testicular histopathologic structure and significantly increased antioxidant enzyme activities. Immunofluorescence staining showed that immune intensity of Beclin-1 and LC3I significantly decreased in the LBP 40 mg/kg group. The results of Q-PCR and western blot analysis showed that LBP 40 mg/kgsignificantly downregulated Beclin-1 and LC3I protein expressions upregulated p-PI3K and p-Akt protein expressions and decreased Beclin-1 and LC3I mRNA expressions compared with diabetic mice. In conclusion, inhibition of PI3K/Akt pathway-mediated testicular excessive autophagy may be a target forprotective effects of LBP on diabetic testicular dysfunction.

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Monday, 06 August

23:51

The Top Five Things To Always Look For When Buying Butter "IndyWatch Feed Health"

 

 

butter grass fed non gmo organic

 

Butter is one of the staple foods in millions of households, and for good reason as it also happens to be one of the healthiest foods out there  as long as you buy the right kind, of course.

In 2005, butter finally broke loose from its nutritional banishment and reclaimed its top spot from longtime rival margarine, which was originally developed by a French chemist way back in 1869.

Lately butter sales have been spurred even more by health trends like the Paleo Diet and Bulletproof Coffee, which centers around mixing grass-fed butter with coffee for a nourishing and stimulating morning drink.

These dietary protocols are very particular about the type of butter allowed, however, which is a good thing considering the many pitfalls of the modern American grocery store.

Here are five things to look for the next time youre in the butter aisle and want to make a healthier choice:

1. Grass-Fed is Best-

If youve ever tried Kerrygold Irish butter before (which by now you probably have considering its the second-best selling butter in the U.S.) youve probably noticed a huge difference between it and the so-called natural stuff served by Land OLakes and other companies.

Grass-fed butter is much higher in healthy Omega-3 fatty acids and Vitamin K2 than butter from cows eating grain-based diets, as well as in conjugated linoleic acid, a powerful and healthy substance that may help prevent heart attacks and can aid in weight loss.

One caveat: the term grass-fed is still not well regulated at all.

Be sure to know your supplier or farmer if you want 100% grass-fed butter....

23:46

Asiatic acid induces colon cancer cell growth inhibition and apoptosis. "IndyWatch Feed Health"

PMID:  Biol Pharm Bull. 2009 Aug ;32(8):1399-405. PMID: 19652380 Abstract Title:  Asiatic acid induces colon cancer cell growth inhibition and apoptosis through mitochondrial death cascade. Abstract:  Cancer is one of the leading causes of death in the world. The triterpenoid compound asiatic acid derived from the tropical medicinal plant Centella asiatica displays cytotoxic activity on fibroblast cells and several other kinds of cells. The present work studies asiatic acid-mediated growth inhibition of cancer cells and the underlying mechanism. Asiatic acid markedly inhibited cancer cell proliferation. Apoptosis of SW480 human colon cancer cells was induced by asiatic acid as shown by flow cytometry, DNA fragmentation and nuclear chromatin condensation experiments. Through increasing mitochondrial membrane permeability and cytochrome c release from mitochondria into cytosol, asiatic acid induced caspase-9 activity, which further activated caspase-3 and poly(ADP-ribose) polymerase cleavage resulting in irreversible apoptotic death in the tumor cells. Taken together, these results suggest that mitochondrial death apoptosis cascade plays very important roles in asiatic acid-induced cancer apoptosis.

read more

23:01

New, Lionel Nation Addresses Climate Engineering Head-On "IndyWatch Feed Health"

Dane Wigington GeoengineeringWatch.org Lionel Nation is an extremely important voice that has fully joined the battle to expose and halt climate engineering. Lionel Nation, has always shown great courage in addressing and exposing the most dire issues on the horizon. In regard to the most critical issue of the global geoengineering assault, Lionel has yet again made

22:51

Inhibitory effect of asiatic acid on acetylcholinesterase. "IndyWatch Feed Health"

PMID:  Phytomedicine. 2012 Feb 15 ;19(3-4):311-6. Epub 2011 Nov 23. PMID: 22112723 Abstract Title:  Inhibitory effect of asiatic acid on acetylcholinesterase, excitatory post synaptic potential and locomotor activity. Abstract:  The asiatic acid, a triterpenoids isolated from Centella asiatica was used to delineate its inhibitory effect on acetylcholinesterase (AChE) properties, excitatory post synaptic potential (EPSP) and locomotor activity. This study is consistent with asiatic acid having an effect on AChE, a selective GABA(B) receptor agonist and no sedative effect on locomotor.

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22:35

Asiatic acid could be a potential candidate for a novel treatment against osteoporosis. "IndyWatch Feed Health"

PMID:  Cell Biochem Biophys. 2014 Mar ;68(2):437-42. PMID: 23934183 Abstract Title:  Asiatic acid inhibits adipogenic differentiation of bone marrow stromal cells. Abstract:  Bone marrow mesenchymal stromal cells (BMSCs) are the common precursors for both osteoblasts and adipocytes. With aging, BMSC osteoblast differentiation decreases whereas BMSC differentiation into adipocytes increases, resulting in increased adipogenesis and bone loss. In the present study, we investigated the effect of asiatic acid (AA) on adipocytic differentiation of BMSCs. AA inhibited the adipogenic induction of lipid accumulation, activity of glycerol-3-phosphate dehydrogenase, and expression of marker genes in adipogenesis: peroxisome proliferation-activated receptor (PPAR), adipocyte fatty acid-binding protein (ap) 2, and adipsin. Further, we found that AA did not alter clonal expansion rate and expression of C/EBP, upstream key regulator of PPAR, and binding activity of C/EBP to PPAR promoter was not affected by AA as well. These findings suggest that AA may modulate differentiation of BMSCs to cause a lineage shift away from the adipocytes, and inhibition of PPAR by AA is through C/EBP-independent mechanisms. Thus, AA could be a potential candidate for a novel drug against osteoporosis.

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21:48

FDA Approves Experimental Hepatitis B Vaccine for Adults Despite Higher Incidence of Heart Attacks "IndyWatch Feed Health"

FDA Licenses New Hepatitis B Vaccine Despite Big Safety Concerns

by Rishma Parpia
The Vaccine Reaction

In February 2018, the Advisory Committee on Immunizations Practices (ACIP) of the Centers for Disease Control and Prevention (CDC) approved the recommendation for a new hepatitis B vaccine, Heplisav-B (HepB-CpG) targeting for adults over the age of 18.1

Heplisav-B is manufactured by Dynavax Technologies Corp. and the new vaccine is given in a two-dose series versus the three dose recommendation for Mercks Recombivax hepatitis B vaccine licensed in 1986 and Glaxo Smith Klines Engerix-B vaccine licensed in 1989.

The U.S. Food and Drug Administration (FDA) had twice rejected Dynavaxs application for licensure for Heplisav-B in the past four years because of safety signals.2

In Dynavaxs third attempt, the FDA granted the license in November 2017, despite unresolved safety concerns. Below is the sequence of events leading to licensure of Heplisav-B.

In 2013, the FDA rejected Dynavaxs license application for Heplisav-B for the first time due to the regulatory agencys concern that the experimental vaccines new adjuvant, which was designed to boost immunogenicity, could lead to development of autoimmune disorders.

Heplisav-B differs from other licensed hepatitis B vaccines in that it contains a new synthetic adjuvant known as cytosine phosphoguanine 1018 (CpG 1018) composed of short synthetic DNA molecules.4

Hepatitis B vaccines previously licensed in the U.S contain alum adjuvants (aluminum salts), which stimulate a general inflammatory response.3

CpG 1018 is believed to stimulate a more specific inflammatory response by producing hepatitis B surface antigen-specific antibodies against the hepatitis B virus.3

According to an article publishe...

21:42

Summertime with Autism and the Living is Lonely "IndyWatch Feed Health"

What could I say that would describe the life of an almost 18 year old with autism? I could fill that pool with tears. Kim

21:36

Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats. "IndyWatch Feed Health"

PMID:  Phytomedicine. 2014 Feb 15 ;21(3):225-32. Epub 2013 Sep 24. PMID: 24075211 Abstract Title:  Antidiabetic and antihyperlipidemic activity of asiatic acid in diabetic rats, role of HMG CoA: in vivo and in silico approaches. Abstract:  Hyperlipidemia is an associated complication of diabetes and also a major risk factor for cardiovascular diseases. The present study was designed to examine the antihyperlipidemic effect of asiatic acid (AA) in streptozotocin (STZ) induced diabetic rats. Diabetes was induced in male Wistar rats by a single intraperitoneal injection of STZ (40 mg/kg b.w.). Diabetic rats show increased plasma glucose, total cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density liprotein, atherogenic index and decreased insulin and high density lipoprotein in diabetic rats. The activity of 3-hydroxy 3-methylglutaryl coenzyme A (HMG CoA) reductase increased significantly in contrast to the activities of lipoprotein lipase and lecithin cholesterol acyltransferase. In addition, the molecular docking of AA against HMG CoA reductase involved in cholesterol biosynthesis using Argus software. Diabetic rats were treated with AA shifted all these parameters towards normalcy. AA has shown best ligand binding energy 11.8122 kcal/mol. The antihyperlipidemic effect of AA was compared with glibenclamide; a well-known antihyperglycemic drug. In conclusion, this study indicates that AA showed an antihyperlipidemic effect in addition to its antidiabetic effect in experimental diabetes.

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21:17

This House Is Just 4,000 And Can Be Built In A Day "IndyWatch Feed Health"

Whether you are renting, buying, or building, a house can be extremely expensive. For most, buying or building a house involves an enormous mortgage. For others, it is out of the question altogether. Looking at the world, the living situation of many is frightening. A billion people in the world live in slums and a... View Article

The post This House Is Just 4,000 And Can Be Built In A Day appeared first on Healthy Holistic Living.

20:48

FDA Approves Experimental Hepatitis B Vaccine for Adults Despite Higher Incidence of Heart Attacks "IndyWatch Feed Health"

FDA Licenses New Hepatitis B Vaccine Despite Big Safety Concerns

by Rishma Parpia
The Vaccine Reaction

In February 2018, the Advisory Committee on Immunizations Practices (ACIP) of the Centers for Disease Control and Prevention (CDC) approved the recommendation for a new hepatitis B vaccine, Heplisav-B (HepB-CpG) targeting for adults over the age of 18.1

Heplisav-B is manufactured by Dynavax Technologies Corp. and the new vaccine is given in a two-dose series versus the three dose recommendation for Mercks Recombivax hepatitis B vaccine licensed in 1986 and Glaxo Smith Klines Engerix-B vaccine licensed in 1989.

The U.S. Food and Drug Administration (FDA) had twice rejected Dynavaxs application for licensure for Heplisav-B in the past four years because of safety signals.2

In Dynavaxs third attempt, the FDA granted the license in November 2017, despite unresolved safety concerns. Below is the sequence of events leading to licensure of Heplisav-B.

In 2013, the FDA rejected Dynavaxs license application for Heplisav-B for the first time due to the regulatory agencys concern that the experimental vaccines new adjuvant, which was designed to boost immunogenicity, could lead to development of autoimmune disorders.

Heplisav-B differs from other licensed hepatitis B vaccines in that it contains a new synthetic adjuvant known as cytosine phosphoguanine 1018 (CpG 1018) composed of short synthetic DNA molecules.4

Hepatitis B vaccines previously licensed in the U.S contain alum adjuvants (aluminum salts), which stimulate a general inflammatory response.3

CpG 1018 is believed to stimulate a more specific inflammatory response by producing hepatitis B surface antigen-specific antibodies against the hepatitis B virus.3

According to an article published i...

20:29

BREAKING: Facebook, YouTube, Apple and Spotify ban Alex Jones and Infowars "IndyWatch Feed Health"

(Note from Erin: This is scary. Regardless of how you feel about Alex Jones this is breaking news happening. Social media giants Facebook and YouTube have put an end to Alex Jones right to free speech and removed all his content.) Facebook and YouTube, as well as Apple (Sunday) and Spotify (Saturday), have all removed []

The post BREAKING: Facebook, YouTube, Apple and Spotify ban Alex Jones and Infowars appeared first on Health Nut News.

20:14

6 Benefits of Saw Palmetto For Women "IndyWatch Feed Health"

6 Benefits of Saw Palmetto For Women

By 

Saw palmetto is a low-growing palm tree that is typically used as an herbal treatment for men with enlarged prostates. But research shows that it can also be beneficial for women, particularly when it comes to counteracting the physical manifestations of too much testosterone (i.e. baldness, acne, excess body hair, etc.)

Lets take a further look at the health benefits for women.

Benefits of Saw Palmetto For Women

1. Treats bladder disorders: According to the National Center for Complementary Alternative Medicine, women who experience bladder disorders, such as urinary tract infections, may benefit from taking saw palmetto. Studies show that it is beneficial for reducing inflammation of the bladder and soothing painful urination.

2. Blocks the overproduction of testosterone: Saw palmetto helps reverse hirsutism, which is the unusual growth of facial or body hair, particularly in women. This is usually caused by an overabundance of hormones in the body. Saw palmetto has the ability to block the overproduction of testosterone in the female body, which will alleviate unwanted hair.

3. Treats hair loss: Dihydrotestosterone (DHT) is derived from the male hormone testosteroneit is also the primary cause of hair l...

19:32

FOX: Coast to Coast AM host Art Bells cause of death revealed "IndyWatch Feed Health"

Art Bell, the radio host most well known for his show Coast to Coast AM and its X-Files-flavored focus on the paranormal, died at his Pahrump, Nevada home on April 13th. He was 72. On Friday it was revealed that he died of an accidental drug overdose. According to the Nye County Sheriffs office, Bells death was the []

The post FOX: Coast to Coast AM host Art Bells cause of death revealed appeared first on Health Nut News.

18:56

About Antibiotics in Survival Settings "IndyWatch Feed Health"

About Antibiotics in Survival Settings

ABOUT ANTIBIOTICS IN SURVIVAL SETTINGS (The following is an excerpt from the introduction to my upcoming book on antibiotics in survival and remote scenarios) In War of the Worlds, a novel by H. G. Wells that became a 1938 radio broadcast and later a hit movie (twice!), an invasion force from Mars attacks the Earth. []

18:08

Macromolecules & Microwave Radiation: Effects On Human Body DNA Fragmentation & Food "IndyWatch Feed Health"

 

By Catherine J. Frompovich

One of the many known characteristics of microwave radiation is that it affects DNA; thats a scientific given which, unfortunately, is not discussed in the literature, etc. published in owners manuals and divulged by industry lobbyists!  Therefore, there is a huge knowledge gap regarding the actual, factual science about microwaves that deliberately has been perpetrated for decades by governments, the military and the microwave industry!

However, with the current push and fast-tracking of 5G Wi-Fi, or higher Gs using millimeter waves, there are numerous secrets high tech, smart tech and microwave tech consumers need to know that are not pretty since most unknowns are about adverse health effects, even though independent science confirms the research and data, but the microwave industry prefers to report consensus science, as submitted by their industry associations, especially ICNIRP.

Recently, I was asked to make a comment submission on the European Food Safety Authoritys draft guidance on harmonized methodologies for human health...

15:33

Trump Reverses Ban on GMOs and Bee-Killing Pesticides in Refuges "IndyWatch Feed Health"

By Jessica Corbett

While regulators in other regions of the world have recently worked to ban bee-poisoning pesticides called neonicotinoids that scientists have long warned could cause an ecological armageddon, the Trump administration just reversed an Obama-era policy that had outlawed the use of neonics and genetically modified crops in the nations wildlife refuges.

The more we learn about the toxicity of neonics, the more apparent it is that pretty much any plant with nectar or pollen sprayed with these poisons is unsafe for bees.
Nathan Donley, Center for Biological Diversity

Defenders of Wildlife CEO and president Jamie Rappaport Clark, who served as director of the U.S. Fish and Wildlife Service (FWS) during the Clinton administration, called the move an insult to our national wildlife refuges and the wildlife that rely on them.

Industrial agriculture has no place on public lands dedicated to conservation of...

15:32

Two elderly men escape nursing home, go to metal festival "IndyWatch Feed Health"

German international broadcaster Deutsche Welle is reporting that two elderly men fled their nursing home last weekend to attend the worlds largest heavy metal festival, Wacken Open Air! RELATED STORY: Preparing to Age Alone The residence home contacted police once it discovered they were gone and responders found them around 3 a.m in attendance at the festival. They were reportedly []

The post Two elderly men escape nursing home, go to metal festival appeared first on Health Nut News.

15:25

Hack Your Unconscious To Boost Your Memory and Learning "IndyWatch Feed Health"

 

By Emma Young

It seems like hard conscious work, but much of the learning process goes on deep in the mind. Here are the top tips to improve how you recall facts.

We tend to think of learning as hard work, requiring a lot of conscious effort. However, much of the process goes on behind the scenes. If you could improve the unconscious processing and retrieval of memories, you could game the system. And it turns out that you can often with very little effort.

If you are learning facts such as foreign phrases or historical dates, giving your study a boost could be as simple as taking a break. Lila Davachi at New York University has found that breaks help to consolidate new memories, improving recall later. However, for a time out to work, different brain cells need to be activated to those you used during the learning period. So, try not to think about what you have just been working on.



Accept your thoughts and feelings as they come
, and let them go. Slowly, become aware of your breathing. If you like, you can ask for help, internally, from a higher power. If you dont, think of the problem you need help with this makes your conscious mind run down to the library of your unconscious mind with an intention. The unconscious then runs through its files of observations, and throws up all that can help you in the given situation.

Better yet, sleep on it. It is well establishe...

15:17

870,000 gallons of raw sewage spill into Florida river "IndyWatch Feed Health"

(Note from Erin: Im not sure how much more I can take; Im exhausted and angry watching the disasters that keep befalling our amazing state and ecosystem here in Florida. Thankfully, the mess has been cleaned up. But, how many other abandoned or ignored pipes exist? When is this going to happen again?) Last Monday, []

The post 870,000 gallons of raw sewage spill into Florida river appeared first on Health Nut News.

14:49

Courtenay Heading Takes on Journalists Regarding HPV Vaccine "IndyWatch Feed Health"

Courtenay Heading from Jurby Wellness tells Beth and Christy on MR Women Today to explain why hes sounding alarms on the HPV vaccine.

The post Courtenay Heading Takes on Journalists Regarding HPV Vaccine appeared first on Vaxxter.

14:48

Big Pharma A House Built on Sand is Collapsing "IndyWatch Feed Health"

If you build a house on unstable ground, that ground will, sooner or later, give way and the building will collapse From The Sermon On The Mount  Everyone therefore who hears these words of mine, and does them, I will liken him to a wise man, who built his house on a rock. The rain Continue reading Big Pharma A House Built on Sand is Collapsing

The post Big Pharma A House Built on Sand is Collapsing appeared first on BolenReport.

14:44

Tumors hate these vitamins despite what these experts claim "IndyWatch Feed Health"

The conventional view of dietary supplements is, for the most part, predictably negative. The New York Times recently offered a perfect demonstration of this view in its April 3 article, Older Americans Are Hooked on Vitamins. In this interview, Dr. Andrew Saul, editor-in-chief of the Orthomolecular Medicine News Service and author of Doctor Yourself: Natural Healing []

The post Tumors hate these vitamins despite what these experts claim appeared first on Health Nut News.

14:35

Neil Young and Daryl Hannah at Monsanto roundup trial "IndyWatch Feed Health"

(Editors Note: Please see the update below from the Monsanto Roundup trial, courtesy of Organic Consumers Association.) Dewayne Johnson v. Monsanto Company is the first Roundup cancer lawsuit to proceed to trial. Plaintiff Dewayne Lee Johnson, a 46-year-old former school groundskeeper, alleges exposure to Monsantos Roundup weed killer and its active ingredient, glyphosate, caused him to develop non-Hodgkin lymphoma []

The post Neil Young and Daryl Hannah at Monsanto roundup trial appeared first on Health Nut News.

14:28

JB Handley: NY Times Vaccine Science "Hostage" Op-Ed is a Gift "IndyWatch Feed Health"

BY J.B. HANDLEY August 6, 2018 Please bookmark and read JB's blog each day - here's an excerpt of his take on the NYT op-ed that none of us can believe was published. You can pre-order his book How To...

14:20

Parents lose custody of disabled adult son for questioning psych drugs "IndyWatch Feed Health"

(Editors Note: Thank you to our friends at Health Impact News for bringing this story to our attention.) Commentary by Terri LaPoint, Health Impact News Medical kidnapping can happen to adults as well as children. Health Impact News has reported a number of adult kidnapping stories over the years. Some involve senior citizens. Others, like this one reported by ABC []

The post Parents lose custody of disabled adult son for questioning psych drugs appeared first on Health Nut News.

14:14

If Your Newborn Baby Could Talk "IndyWatch Feed Health"

By Laura Hayes What if your baby could talk? Here are some things I think they would surely say: Please dont poke me with sharp needles! Those hurt! You wouldnt let anyone pinch or hit me, so why are you...

14:00

Distraction paper pulled for clerical error "IndyWatch Feed Health"

The authors of a 2018 paper on how noisy distractions disrupt memory are retracting the article after finding a flaw in their study. The paper, Unexpected events disrupt visuomotor working memory and increase guessing, appeared in Psychonomic Bulletin & Review, a publication of the Psychonomic Society. (For those keeping score at home, psychonomics is the Continue reading Distraction paper pulled for clerical error

12:02

Psychologists Are in a Nasty Fight About a Report on Torture "IndyWatch Feed Health"

From Buzzfeed News: This month in San Francisco, the American Psychological Association will vote on a proposal that would return psychologists working for the military to the detention camp at the Guantnamo Bay naval base in Cuba.

The vote by the associations 178-member governing council will take place against the backdrop of a bitter dispute over a 2015 report commissioned by the APA that found the organization colluded with the Pentagon to allow harsh interrogation methods, including sleep deprivation and painful stress positions. Some psychologists criticized in the report dispute its findings and have sued the organization for defamation.

The new proposal  backed by the associations leaders says that APA members at Guantnamo would be restricted to working in a health care role, treating both military staff at the base and the remaining detainees, who were rounded up in President George W. Bushs war on terror.'

Article 

12:01

What Is Critical Psychology? New Site for Scholar-Activists "IndyWatch Feed Health"

From Robert Beshara: I am pleased to announce that on behalf of the Critical Praxis Collective, I have put together a website which will serve as a resource for students, faculty, and nonacademics: www.criticalpsychology.org. This website is one step in the direction of critical praxis, which entails transdisciplinary collaboration between critical scholars and radical activists.

Feel free to browse through the site. The idea is that it serves as a free collaborative resource, so if you have any corrections or suggestions, do let me know. I am open to making changes.

Website

07:00

Weekly Health Quiz: Fatigue, Sugar and Fasting "IndyWatch Feed Health"

1 Which of the following statements is true?

  • Drinking whole milk increases your risk of early death
  • Drinking low-fat milk is associated with improved health and a lower risk of death
  • Evidence does not support guidelines that discourage saturated fat consumption

    A 2014 systematic review concluded current evidence does not support cardiovascular guidelines that discourage saturated fat consumption. Other studies also support consumption of full-fat dairy products such as whole milk, cheese, butter and yogurt. Learn more.

  • Eating high-fat cheese raises harmful LDL cholesterol

2 An analysis of 97 peer-reviewed studies found wireless technologies are impacting the environment by:

  • Harming mammals, birds, insects and plants

    An analysis of peer-reviewed studies concluded wireless technologies are harming mammals, birds, insects and plants. Learn more.

  • Boosting plant growth
  • Killing rodents and other pests
  • Making insects grow larger

3 Which of the following has been identified as the driving factor behind the rising death toll from liver disease?

  • Excessive alcohol consumption

    Cirrhosis cases nearly doubled between 2001 and 2013, and deaths from cirrhosis increased by 65 percent between 1999 and 2016. According to researchers, the rise in cirrhosis mortality is entirely driven by excess alc...

Top Destination Sites for Health and Wellness "IndyWatch Feed Health"

By Dr. Mercola

More than half the U.S. population is struggling with chronic illness,1 and 1 in 5 deaths is obesity related.2 We have overwhelming rates of heart disease, cancer and Alzheimer's, and future projections only look worse. One of the saddest aspects, though, is that advice given by governmental entities and conventional medicine has utterly failed when it comes to disease prevention. The good news is, it doesn't have to be this way. Aspects of health are multiple and varied, especially in recent years since a greater emphasis has been placed on fitness, disease prevention and optimal health.

That's where we come in. When it comes to finding accurate and up-to-the-moment information you need to improve or maintain your health such as the importance of balancing your sodium and potassium ratios, how to manage crucial mitochondrial function or the vital differences between omega-3s and omega-6s Mercola.com has it covered.

For example, magnesium is among the most common nutrient deficiencies, and sets the stage for deterioration of proper metabolic function that typically snowballs into more significant health problems. But you can keep your magnesium levels in a therapeutic range by eating a varied diet and including dark leafy vegetables, seaweed and some beans, nuts and seeds, like pumpkin, sesame and sunflower seeds, which can be great sources of magnesium.

This is precisely the type of information you can find using Mercola.com to access what you need, now. If you know your body requires more of a certain vitamin or mineral, or if you're interested in consuming foods containing antioxidants, you can peruse the food options, find the ones that meet your nutritional needs and plan your meals accordingly.

Multiple branches of information at Mercola.com allow you to read more about what you're interested in; just click on the sites below each section. Whether it's information about supplementation, beneficial compounds you put in and on your body or the differences between essential oils (not to mention cooking oils), you'll find it here. The categories listed and covered below are:

Tea

Food Facts

Herbs & Spices

Vitamins & Supple...

Mercola.com Celebrates 21st Anniversary "IndyWatch Feed Health"

By Dr. Mercola

Today is a special celebration, as we share Mercola.coms 21st anniversary with you! I graduated medical school in 1982. I finished my residency and opened my private practice in 1985, where in the decades that followed I had the privilege of treating well over 20,000 patients. Alongside medicine, Ive always had a passion for technology, which led to the launch of this website in 1997.

These days, my time is dedicated to research and sharing my knowledge and findings with you. Through the years, weve reached hundreds of millions of people through this site, which has grown exponentially over the past two decades. While the look and feel of this site has morphed through the years, my intention for its existence has never changed.

Your Optimal Health Is My Goal and Mission

My goal has always been to provide you with all the information you need to take control of your health free of charge! I am so happy to have the ability to interview world leading experts, which now number in the hundreds learning with you along the way. I only have this ability because of the success of this website because of your support!

You have enabled millions more to get this information, as this site is now available in 10 different languages: English, Spanish, French, Korean, Chinese, Japanese, Portuguese, Russian, German and Polish. We have also built the worlds best natural health website for your pets HealthyPets.Mercola.com led by Dr. Karen Becker, a whole-spectrum veterinarian, to help you optimize your pet's health as well.

Product Updates

Aside from providing free health information, I am also passionate about making the highest quality products and providing the best possible service. Its unlikely you were reading this site 21 years ago, so you probably dont remember the very first product I created to help fund our mission and that of our nonprofit partners. That product was a cookbook called Just What the Doctor Ordered.

This was the ketogenic cookbook before keto even existed. Weve come a long way since then, and now have a full line of supplements, foods, drinks, air and water filters, and even a line of organic clothing certified to the highest regenerative standards.

Most recently, we launched our first biodynamic product a certified biodynamic moringa powder and this is just the beginning of our biodynamic lineup as we continue to bring regener...

06:01

Suicide in the Age of Prozac "IndyWatch Feed Health"

In June, the Centers for Disease Control reported that the suicide rate in the United States had increased 30% from 1999 to 2016, with more Americans killing themselves than ever before. The CDC has been sounding this alarm for several years now, stirring headlineseach time it issues its annual reportof a public health crisis.

Here are just a few of the headlines that have appeared:

Although the media reports may tell of social factors that can contribute to suicide, such as unemployment, the language in the articles often tell of a medical crisis. Mental health experts say mental health screening would help people get into treatment before their depression becomes severe, Voice of America News wrote, in an article on the CDC report. Other recommendations include reducing the social stigma associated with mental illness and making treatment more widely available.

The American Foundation for Suicide Prevention, which has been promoting suicide awareness programs since the late 1980s, similarly tells of how ninety percent of people who die by suicide have a mental disorder at the time of their deaths. The most common disorder associated with suicide, the Foundation states, is depression, an illness that goes undiagnosed and untreated far too often. It advises reporters to convey that suicidal thoughts and behaviors can be reduced with the proper mental health support and treatment.

This rise in suicide certainly deserves societal attention. But given that it has occurred during a time when an ever greater number of people are getting mental health tr...

03:09

Medically Researched Causes of Clay or Pale Colored Stool & Treatments "IndyWatch Feed Health"

Clay or pale colored stool can be a cause for alarm as it can indicate a medical issue. Clay stool is usually a sign that there is a problem with your gallbladder, liver, pancreas, or bile ducts (biliary system). Whitish, clay or gray stool usually happens when digestive bile cant get to your small intestine to help with the digestion of food, as bile gives poop its brown color. Acholic stool is another name for pale, clay or whitish colored stool due to a lack of bile.

Clay, light gray or pale colored stools can also be a result of a parasite infection, viral infection, or issue with your digestion

In some cases, white, pale or clay stool can be associated with other symptoms such as yellowing of the skin and eyes, pain in your right upper abdomen, or nausea.

What is Clay or Pale Colored Stool?

Clay-colored stool usually indicates a lack of bile in your small intestine. Bile produced by your liver and stored in your gallbladder is responsible for the typical brown color of your stool. A lack of bile in your digestive process will result in stool that is gray, pale or clay-colored.

Dr. Benjamin Wedro on MedicineNet says that a compound in bile called bilirubin turns stool brown during digestion. Light to dark brown poop is a sign of a healthy digestive system. However, a number of conditions can affect how your digestion works.1

Symptoms Associated with Clay Stool

Passing whitish, gray or clay poop is generally associated with issues in your biliary system. The biliary system is composed of the organs and ducts that produce, store and transport bile. Therefore, along with clay or pale feces, you will usually have other symptoms.

According to doctors from the Mayo Clinic, you may have the following symptoms along with white chalky stool:2

00:49

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. "IndyWatch Feed Health"

PMID:  Eur J Pharmacol. 2012 Mar 15 ;679(1-3):51-9. Epub 2012 Jan 24. PMID: 22296759 Abstract Title:  Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis. Abstract:  Ceramides derived from sphingosine contribute to the apoptotic processes of neuronal cells in neurodegenerative disorders including Alzheimer's disease. This study investigates the potential neuroprotective effects of Asiatic acid, a triterpenoid derived from Centella asiatica, against C(2)-ceramides-induced cell death in primary cultured rat cortical neuronal cells. In primary neurons, Asiatic acid (0.01 to 1.0mol/l) reduced C(2)-ceramide-induced cell death and mitochondria membrane potential loss in a concentration-dependent manner. Furthermore, Asiatic acid decreased cellular production of reactive oxygen species following C(2)-ceramide treatment. At a maximal concentration of 1.0 mol/l, Asiatic acid partly counteracted the pro-apoptotic effects of the C(2)-ceramide by reducing the cytosolic release of HtrA2/Omi, the upregulation of Bax and caspase 3, as well as the dephosphorlyation of ERK1/2. Taken together, these data suggest that Asiatic acid protects neurons from C(2)-ceramide-induced cell death by antagonizing mitochondria-dependent apoptosis.

read more

00:45

America #1 in Child Sex Trafficking and Pedophilia CPS and Foster Care are the Pipelines "IndyWatch Feed Health"

US map, statute of liberty, open hands stating Human Trafficking and Sex Slavery image

by Brian Shilhavy
Editor, Health Impact News

Many Americans hold to a national pride that believes the United States is, or at least was, the greatest country in the world.

Few would argue that America is not what it used to be when considering the greatness of America today.

Current American President Donald Trump was swept into power because he ran on a campaign slogan to Make America Great Again (MAGA), suggesting that what was once considered great in America no longer is.

This pride that America is greater than most other countries of the world, that it is the land of opportunity and hope, was perhaps best articulated by the American poet Emma Lazarus who penned the following words that today are etched into a plaque attached to the Statute of Liberty standing in the harbor of New York City, which was once considered the gateway to America:

Give me your tired, your poor, Your huddled masses yearning to breathe free, The wretched refuse of your teeming shore.

Send these, the homeless, tempest-tost to me, I lift my lamp beside the golden door!

Today, depending on how one measures greatness, America could still be considered greater than other countries in certain aspects, such as having the worlds largest economy, or the worlds most powerful military force.

But there is one area where America exceeds all other nations of the world that hopefully most Americans would not be proud to admit: America is the #1 destination for pedophilia and child sex trafficking, and this huge market exists mainly because it is funded by taxpayers through the U.S. government Child Protection Services and foster care system.

The Problem of Child Sex Trafficking in the U.S. Is Real and Documented

not-for-sale-child

In 2016, Sen. Rob Portman (R-Ohio)...

00:42

Asiatic acid inhibits lliver fibrosis. "IndyWatch Feed Health"

PMID:  PLoS One. 2012 ;7(2):e31350. Epub 2012 Feb 7. PMID: 22363627 Abstract Title:  Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro. Abstract:  Liver fibrosis is a major cause of liver failure, but treatment remains ineffective. In the present study, we investigated the mechanisms and anti-hepatofibrotic activities of asiatic acid (AA) in a rat model of liver fibrosis induced by carbon tetrachloride (CCl(4)) and in vitro in TGF-beta1-stimulated rat hepatic stellate cell line (HSC-T6). Treatment with AA significantly attenuated CCl(4)-induced liver fibrosis and functional impairment in a dosage-dependent manner, including blockade of the activation of HSC as determined by inhibiting de novo alpha smooth muscle actin (a-SMA) and collagen matrix expression, and an increase in ALT and AST (all p

read more

00:32

Asiatic acid attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. "IndyWatch Feed Health"

PMID:  Acta Pharmacol Sin. 2012 May ;33(5):578-87. Epub 2012 Mar 26. PMID: 22447225 Abstract Title:  Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. Abstract:  AIM: To investigate whether asiatic acid (AA), a pentacyclic triterpene in Centella asiatica, exerted neuroprotective effects in vitro and in vivo, and to determine the underlying mechanisms.METHODS: Human neuroblastoma SH-SY5Y cells were used for in vitro study. Cell viability was determined with the MTT assay. Hoechst 33342 staining and flow cytometry were used to examine the apoptosis. The mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were measured using fluorescent dye. PGC-1 and Sirt1 levels were examined using Western blotting. Neonatal mice were given monosodium glutamate (2.5 mg/g) subcutaneously at the neck from postnatal day (PD) 7 to 13, and orally administered with AA on PD 14 daily for 30 d. The learning and memory of the mice were evaluated with the Morris water maze test. HE staining was used to analyze the pyramidal layer structure in the CA1 and CA3 regions.RESULTS: Pretreatment of SH-SY5Y cells with AA (0.1-100 nmol/L) attenuated toxicity induced by 10 mmol/L glutamate in a concentration-dependent manner. AA 10 nmol/L significantly decreased apoptotic cell death and reduced reactive oxygen species (ROS), stabilized the mitochondrial membrane potential (MMP), and promoted the expression of PGC-1 and Sirt1. In the mice models, oral administration of AA (100 mg/kg) significantly attenuated cognitive deficits in the Morris water maze test, and restored lipid peroxidation and glutathione and the activity of SOD in the hippocampus and cortex to the control levels. AA (50 and 100 mg/kg) also attenuated neuronal damage of the pyramidal layer in the CA1 and CA3 regions.CONCLUSION: AA attenuates glutamate-induced cognitive deficits of mice and protects SH-SY5Y cells against glutamate-induced apoptosis in vitro.

read more

00:22

This study shows asiatic acid is effective against multiple models of focal ischemia. "IndyWatch Feed Health"

PMID:  Stroke. 2012 Jun ;43(6):1632-8. Epub 2012 Apr 17. PMID: 22511009 Abstract Title:  Asiatic acid attenuates infarct volume, mitochondrial dysfunction, and matrix metalloproteinase-9 induction after focal cerebral ischemia. Abstract:  BACKGROUND AND PURPOSE: Asiatic acid (AA) has been shown to attenuate cerebral infarction in a mouse model of focal ischemia and shows promise as a neuroprotective stroke therapy. To facilitate translation of these findings to clinical studies, we determined pharmacokinetics, a dose-response relationship, the therapeutic time window, and efficacy using multiple stroke models. We also explored potential mechanisms of action.METHODS: Escalating doses of intravenous AA were administered and serum concentrations were measured at multiple time points for the pharmacokinetic studies. Subsequently, a dose-response relationship was determined followed by administration at different intervals after the onset of ischemia to establish a therapeutic time window for neuroprotection. Outcome measurements included both histological and behavioral. Mitochondrial function and matrix metalloproteinase activity in controls and treated rats were also determined.RESULTS: The pharmacokinetic studies showed that AA (75 mg/kg) has a half-life of 2.0 hours. AA significantly decreased infarct volume and improved neurological outcome even when administration was at time points up to 12 hours after the onset of ischemia. Infarct volume was also significantly decreased in female rats and spontaneously hypertensive rats. AA attenuated mitochondrial dysfunction and reduced matrix metalloproteinase-9 induction.CONCLUSIONS: Our study shows AA is effective against multiple models of focal ischemia, has a long therapeutic time window, and is also effective in females and hypertensive animals. AA may mediate neuroprotection by protecting mitochondria and inhibiting matrix metalloproteinase-9 induction and activation. Taken together these data suggest that AA is an excellent candidate for development as a stroke therapy.

read more

00:05

America #1 in Child Sex Trafficking and Pedophilia CPS and Foster Care are the Pipelines "IndyWatch Feed Health"

US map, statute of liberty, open hands stating Human Trafficking and Sex Slavery image

by Brian Shilhavy
Editor, Health Impact News

Many Americans hold to a national pride that believes the United States is, or at least was, the greatest country in the world.

Few would argue that America is not what it used to be when considering the greatness of America today.

Current American President Donald Trump was swept into power because he ran on a campaign slogan to Make America Great Again (MAGA), suggesting that what was once considered great in America no longer is.

This pride that America is greater than most other countries of the world, that it is the land of opportunity and hope, was perhaps best articulated by the American poet Emma Lazarus who penned the following words that today are etched into a plaque attached to the Statute of Liberty standing in the harbor of New York City, which was once considered the gateway to America:

Give me your tired, your poor, Your huddled masses yearning to breathe free, The wretched refuse of your teeming shore.

Send these, the homeless, tempest-tost to me, I lift my lamp beside the golden door!

Today, depending on how one measures greatness, America could still be considered greater than other countries in certain aspects, such as having the worlds largest economy, or the worlds most powerful military force.

But there is one area where America exceeds all other nations of the world that hopefully most Americans would not be proud to admit: America is the #1 destination for pedophilia and child sex trafficking, and this huge market exists mainly because it is funded by taxpayers through the U.S. government Child Protection Services and foster care system.

The Problem of Child Sex Trafficking in the U.S. Is Real and Documented

not-for-sale-child

...

Sunday, 05 August

16:17

Potsdam village board will vote on fluoridation before end of September "IndyWatch Feed Health"

POTSDAM The village board will vote on whether or not to continue fluoridating municipal water either at its August or September meeting.

Village Administrator Greg Thompson said that after a meeting with officials from Walden, New York, which voted to drop its fluoridation program, and with a statement to the Board of Trustees from the St. Lawrence County Board of Health strongly supporting fluoridation, he feels the board will have all the information they need to make a decision on the issue.

Residents of St. Lawrence County are especially likely to suffer if the Village decides to stop providing this well-established safety measure, said Board of Health President Dr. Andrew Williams in a notice to Potsdam. The board strongly urges the village to continue fluoridation.

You can read reports all day long. There are thousands for and thousands against fluoridation, Thompson said. He said the best advice he got from the representatives from Walden was to tell the board to vote your heart and follow through.

Mayor Ron Tischler, Trustee Abby Lee and Thompson met with officials from Walden . seeking information on what would be required of the Potsdam board if they choose to discontinue fluoridation, as Walden has.

It was good to talk to someone whos been through the process, and what the pitfalls are, Lee said.

They told us about their process, their thinking on it. They were very helpful.

Advice from Walden

In particular, she said, they warned of the changing nature of applicable law, which has changed since Canton ceased fluoridation in 2003 and even since Walden voted to end treatment last October.

The state Department of Health has outlined what steps would have to be taken to end the water treatment, but since the law governing the process, Public Health Law 1100-a, has been undergoing changes, the departments best advice to Potsdam has been to seek the help of lawyers, Lee said.

What is clear, she said, is that if the village decides to cease fluoridation, there is a process that must be followed, but if they simply replace the existing equipment and continue fluoridation, it is a much simpler operation.

Fluoridation of water for prevention of tooth decay has been a controversial topic for decades, with opponents claiming to have strong evidence that adding fluoride to municipal water is dangerous enough that it could compromise the health of people in communities where fluoridation is done.

But the county Board of Health says the preponderance of evidence, from informed and authoritative sources, overwhelmingly indicates of th...

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