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Wednesday, 20 September

00:01

Miracle Weed Killer Dicamba was Supposed to Save Farms Instead its Devastating Them "IndyWatch Feed Health"

Dicamba_damage_in_grapes_1200x600

by CAITLIN DEWEY
Pittsburgh Post-Gazette

Excerpts:

Clay Mayes slams on the brakes of his Chevy Silverado and jumps out with the engine running, yelling at a dogwood by the side of the dirt road as if it said something insulting.

Its leaves curl downward and in on themselves like tiny, broken umbrellas. Its the telltale mark of inadvertent exposure to a controversial herbicide called dicamba.

This is crazy. Crazy! shouts Mayes, a farm manager, gesticulating toward the shriveled canopy off Highway 61. I just think if this keeps going on. . .

Everythingll be dead, says Brian Smith, his passenger.

The damage here in northeast Arkansas and across the Midwest sickly soybeans, trees and other crops has become emblematic of a deepening crisis in American agriculture.

Farmers are locked in an arms race between ever-stronger weeds and ever-stronger weed killers.

The dicamba system, approved for use for the first time this spring, was supposed to break the cycle and guarantee weed control in soybeans and cotton. The herbicide used in combination with a genetically modified dicamba-resistant soybean promises better control of unwanted plants such as pigweed, which has become resistant to common weed killers.

The problem, farmers and weed scientists say, is that dicamba has drifted from the fields where it was sprayed, damaging millions of acres of unprotected soybeans and other crops in what some are calling a man-made disaster. Critics contend that the herbicide was approved by federal officials without enough data, particularly on the critical question of whether it could drift off target.

Read the full story at the...

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Tuesday, 19 September

23:53

Vaccines save lives a response to some ridiculous claims about drugs "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

The internet is filled with crackpot ideas. I know, thats a shocker. In todays crazy, we have this article, Six pharmaceutical drugs that immediately destroy your health. Setting aside the odd pharmaceutical drugs, let me counter that with pharmaceuticals save lives. Even more, vaccines save lives (since they attack two of my favorite vaccines). I

Skeptical Raptor

23:06

Thymoquinone has a protective effect against lead-induced alteration of the antioxidant defense system in rat livers. "IndyWatch Feed Health"

PMID:  Acta Biol Hung. 2017 Sep ;68(3):248-254. PMID: 28901799 Abstract Title:  Protective effect of thymoquinone against lead-induced antioxidant defense system alteration in rat liver. Abstract:  Alteration of the antioxidant system may be related to lead (Pb) hepatotoxicity. This study was carried out to investigate the possible beneficial effect of thymoquinone (TQ), the major active ingredient of volatile oil of Nigella sativa seeds, against Pb-induced liver antioxidant defense system impairment. Adult male rats were randomized into four groups: control group received no treatment, Pb group was exposed to 2000 ppm of Pb acetate in drinking water, Pb-TQ group was cotreated with Pb plus TQ (5 mg/kg/day, per os) and TQ group receiving only TQ. All treatments were applied for five weeks. TQ alone did not induce any significant changes in the enzymatic and non-enzymatic antioxidant status. By contrast, Pb exposure significantly decreased not only reduced glutathione level, but also superoxide dismutase, glutathione peroxidase, catalase and glutathione reductase activities in the liver tissue. Interestingly, when coadministrated with Pb, TQ significantly improved the affected antioxidant parameters. In conclusion, our results indicate a protective effect of TQ against Pb-induced liver antioxidant capacity impairment and suggest that this component might be a clinically promising alternative in Pb hepatotoxicity.

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22:54

Practising Transcendental meditation may potentially reduce the systolic blood pressure. "IndyWatch Feed Health"

PMID:  Complement Ther Med. 2017 Oct ;34:26-34. Epub 2017 Jul 24. PMID: 28917372 Abstract Title:  Transcendental meditation for lowering blood pressure: An overview of systematic reviews and meta-analyses. Abstract:  BACKGROUND: Transcendental meditation (TM) is a stress reduction technique that can potentially lower blood pressure (BP) safely. The American Heart Association recommends that TM may be considered in clinical practice.OBJECTIVE: To provide an overview of all systematic reviews and meta-analyses of TM on BP for evidence-informed clinical decision making.METHOD: Systematic searches of PubMed, EBSCOhost, Cochrane Library, Web of Science, Embase, and PsycINFO for all systematic reviews and/or meta-analyses of randomized controlled trials (RCTs) with TM as an intervention, and outcome measures include systolic BP (SBP) and diastolic BP (DBP). Qualitative and quantitative data were synthesized. The methodological quality of the selected reviews was assessed using the AMSTAR checklist.RESULTS: Eight systematic reviews and meta-analyses are included. Among them is an Agency for Healthcare Research and Quality report, a Cochrane systematic review, 4 independent reviews, and 2 reviews from a TM related institution. The quality of most of the included reviews is fair with a mean score of 5.75/11 on the AMSTAR scale. Overall, there exists a clear trend of increasing evidence over the years supporting the efficacy of TM in lowering BP. However, some conflicting findings remain across reviews and potential risk of bias exists in many of the RCTs included in these reviews.CONCLUSION: Practising TM may potentially reduce the SBP by4mm Hg and DBP by 2mm Hg. Such effect is comparable with other lifestyle interventions such as weight-loss diet and exercise. Further evidence from long-term well-designed RCTs conducted by independent researchers is needed.

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22:43

Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty. "IndyWatch Feed Health"

PMID:  Food Chem Toxicol. 2017 Sep 6 ;109(Pt 1):272-283. Epub 2017 Sep 6. PMID: 28887090 Abstract Title:  Vitamin C partially prevents reproductive damage in adult male rats exposed to rosuvastatin during prepuberty. Abstract:  Pediatric obesity is closely associated with dyslipidemias and environmental factors, such as diet and lack of physical exercises, which may alter lipid profile in children. Rosuvastatin decreases serum total cholesterol and triglycerides concentrations. Vitamin C (ascorbic acid) plays an important role on sperm integrity and fertility. Juvenile male rats were distributed into six experimental groups that received saline solution 0.9%, 3 or 10 mg/kg/day of rosuvastatin, 150 mg/day of ascorbic acid, or 3 or 10 mg/kg/day of rosuvastatin co-administered with 150 mg/day of ascorbic acid from PND23 until PND53 and then the rats were maintained until sexual maturity. Rosuvastatin-exposed groups showed lower sperm quality, androgen depletion and germ cell death. Ascorbic acid was capable to prevent partially the reproductive adverse effects provoked by rosuvastatin. In conclusion, prepubertal exposure to rosuvastatin provokes long-term reproductive damages at sexual maturity and ascorbic acid supplementation at prepuberty may be a preventive mode against these reproductive adverse effects.

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22:11

Why Plant-Based Diets Are The Nutritional Equivalent of Quitting Smoking "IndyWatch Feed Health"

This article is shared with permission from our friends at NutritionFacts. Despite the most widely accepted and well-established chronic disease practice guidelines uniformly calling for lifestyle change as the first line of therapy, doctors often dont follow these recommendations. As seen in my video, The Best Kept Secret in Medicine, lifestyle interventions are not...

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The post Why Plant-Based Diets Are The Nutritional Equivalent of Quitting Smoking appeared first on Healthy Holistic Living.

22:08

If You Have Sausage Fingers That are Always Swollen, You Need To Read This "IndyWatch Feed Health"

This article is shared with permission from our friends at Doctors Health Press. Disclaimer: Results are not guaranteed*** and may vary from person to person***. Having dactylitis or sausage fingers can be both embarrassing and painful. The dactylitis definition is simply the inflammation of the fingers or toes. It can also have...

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The post If You Have Sausage Fingers That are Always Swollen, You Need To Read This appeared first on Healthy Holistic Living.

22:05

9 Reasons You Still Have Pimples and The Natural Remedies To Fix It "IndyWatch Feed Health"

This article is shared with permission from our friends at Alina Islam. Acne isnt something thats supposed to happen once youve past your teenage years, right? If youre like me, youve been dealing with acne for a large part of your life. Youve probably tried every acne-fighting product on the market...

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The post 9 Reasons You Still Have Pimples and The Natural Remedies To Fix It appeared first on Healthy Holistic Living.

22:01

13 Signs That Your Fear of Failure is Not Normal "IndyWatch Feed Health"

This article is shared with permission from our friends at Doctors Health Press. Disclaimer: Results are not guaranteed*** and may vary from person to person***. Its probably safe to say that weve all had a fear of failing at one point or another. Maybe it was before a big test at school...

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The post 13 Signs That Your Fear of Failure is Not Normal appeared first on Healthy Holistic Living.

22:00

Dr Ron Unfiltered Uncensored Post Irma "IndyWatch Feed Health"

Drs Ron Gerry ad Danw with over 150 years of combined experience bring you the news that you need to know. We interpret the studies and give you information not available from main stream bought and paid for medicine   We are on most platforms including Google Pay, Stitcher, Blubrry, TuneIn and others and also here at Blog Talk Radio.

21:59

Are You Afraid of Being Too Happy? Turns Out Theres a Name For That "IndyWatch Feed Health"

This article is shared with permission from our friends at Doctors Health Press. Disclaimer: Results are not guaranteed*** and may vary from person to person***. There are many fears we face in our life and phobias are an issue for millions of people. Cherophobia may be an uncommon phobia, but it...

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The post Are You Afraid of Being Too Happy? Turns Out Theres a Name For That appeared first on Healthy Holistic Living.

21:58

Combined application of Grifola frondosa and vitamin C induced cell apoptosis and autophagy in vitro. "IndyWatch Feed Health"

PMID:  Apoptosis. 2017 Sep 11. Epub 2017 Sep 11. PMID: 28894987 Abstract Title:  The induction of apoptosis and autophagy in human hepatoma SMMC-7721 cells by combined treatment with vitamin C and polysaccharides extracted from Grifola frondosa. Abstract:  Polysaccharides extracted from the mushroom Grifola frondosa (GFP) are a potential anticancer agent. The objective of this study was to investigate the effect of GFP and vitamin C (VC) alone and in combination on the viability of human hepatocarcinoma SMMC-7721 and HepG2 cells. Studies designed to detect cell apoptosis and autophagy were also conducted to investigate the mechanism. Results from the cell viability assay indicated that a combination of GFP (0.2 or 0.25 mg/mL) and VC (0.3 mmol/L) (GFP/VC) led to 52.73 and 53.93% reduction in cell viability of SMMC-7721 and HepG2 cells separately after 24 h. Flow cytometric analysis indicated that GFP/VC treatment induced cell cycle arrest at the G2/M phase, and apoptosis occurred in approximately 43.62 and 42.46% of the SMMC-7721 and HepG2 cells separately. Moreover, results of Hoechst33258 and monodansylcadaverine staining, and transmission electron microscopy, showed that GFP/VC induced apoptosis and autophagy in SMMC-7721 and HepG2 cells. Western blot analysis showed changes in the expression of apoptosis-related proteins [upregulation of BAX and caspase-3, downregulation of Bcl-2, and activation of poly-(ADP-ribose)-polymerase] and autophagy protein markers (upregulation of beclin-1 and microtubule-associated protein 1A/1B light chain-3). We also demonstrated that the expression of both Akt andp-Akt was enhanced, suggesting the PI3K/Akt/mTOR pathway might not be involved in this process. Our study shows that the combined application of GFP and VC induced cell apoptosis and autophagy in vitro, and might have antitumor activity in vivo.

read more

21:56

7 Foods You Eat Everyday That Make Period Cramps Worse "IndyWatch Feed Health"

This article is shared with permission from our friends at Alina Islam. Have you ever had to skip work because of bad period cramps? Do you keep Advil in your purse at all times during that week? Do you feel like you waste at least an entire day every month...

More

The post 7 Foods You Eat Everyday That Make Period Cramps Worse appeared first on Healthy Holistic Living.

21:53

Cardiff University Expels Student Who Refused to be Vaccinated "IndyWatch Feed Health"

Cardiff University for All

Cardiff University promotes itself as a University for all. But apparently that does not include students who refuse vaccinations. Image Source.

by Christina England
Health Impact News

Currently, vaccinations are not mandatory in the UK and, according to recent reports, the UKs position on mandatory vaccination is unlikely to change.

Background Information on the UKs Decision

According to the British Medical Association, in 2003, the Department of Health issued guidelines clearly stating that none of the vaccinations available in the UK were compulsory and that they were all offered on a voluntary basis.

The guidelines stated:

UK policy on compulsory vaccination:

All immunisations in the UK are voluntary. Determining the factors that contribute to vaccination compliance is essential to the success of implementing future vaccination programmes. Across Europe the trend has been toward greater voluntary participation. Countries such as Germany, where compulsion was the rule a couple of decades ago, now rely on voluntary acceptance. Even though vaccination in the UK is not compulsory, some pre-schools/nurseries refuse entry if children are not fully vaccinated. In March 2003, the Department of Health issued the following statement, None of the childhood vaccinations available in the UK are compulsory. They are offered on a voluntary basis. There are no plans to alter this policy.

These issues were once again debated by the British Medical Association (BMA) earlier this year, and once again, UK doctors voted against making vaccinations compulsory in the UK.

In a recent article discussing the BMAs decision, the Daily Mail stated that:

Doctors leaders have rejected the...

21:46

Exogenous ascorbic acid improves defence responses of sunflower exposed to multiple stresses. "IndyWatch Feed Health"

PMID:  Acta Biol Hung. 2017 Sep ;68(3):290-299. PMID: 28901807 Abstract Title:  Exogenous ascorbic acid improves defence responses of sunflower (Helianthus annuus) exposed to multiple stresses. Abstract:  Ascorbic acid is an important antioxidant that plays role both on growth and development and also stress response of the plant. The purpose of this study was to determine the effect of ascorbate on physiological and biochemical changes of sunflower that was exposed to multiple stresses. Chlorophyll and carotenoid contents decreased and glutathione, ascorbate and malondialdehyde contents as well as antioxidant enzyme activities increased for sunflower plant that was exposed to 50 mM NaCl and pendimethalin at different concentrations. These changes were found to be more significant in groups simultaneously exposed to both stress factors. While malondialdehyde content decreased, chlorophyll, carotenoid, ascorbate, glutathione contents and antioxidant enzyme activities increased in plants treated exogenously with ascorbate, compared to the untreated samples. According to the findings of our study; compared to individual stress, the effect of stress is more pronounced in sunflower exposed to multiple stresses, and treatment with exogenous ascorbate reduces the negative effects of stress.

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21:45

This Chocolate-Coconut Bar Recipe Will Help Keep Your Colon Clean and Healthy "IndyWatch Feed Health"

 This article is shared with permission from our friends at Holistic  Saffron. Natural Remedies  For Constipation Constipation is a common complaint amongst children and adults. OTC and Prescription constipation drugs come with lots of long-term side effects. Even if your babys pediatrician says that Miralax is safe know that it...

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The post This Chocolate-Coconut Bar Recipe Will Help Keep Your Colon Clean and Healthy appeared first on Healthy Holistic Living.

21:31

Cardiff University Expels Student Who Refused to be Vaccinated "IndyWatch Feed Health"

Cardiff University for All

Cardiff University promotes itself as a University for all. But apparently that does not include students who refuse vaccinations. Image Source.

by Christina England
Health Impact News

Currently, vaccinations are not mandatory in the UK and, according to recent reports, the UKs position on mandatory vaccination is unlikely to change.

Background Information on the UKs Decision

According to the British Medical Association, in 2003, the Department of Health issued guidelines clearly stating that none of the vaccinations available in the UK were compulsory and that they were all offered on a voluntary basis.

The guidelines stated:

UK policy on compulsory vaccination:

All immunisations in the UK are voluntary. Determining the factors that contribute to vaccination compliance is essential to the success of implementing future vaccination programmes. Across Europe the trend has been toward greater voluntary participation. Countries such as Germany, where compulsion was the rule a couple of decades ago, now rely on voluntary acceptance. Even though vaccination in the UK is not compulsory, some pre-schools/nurseries refuse entry if children are not fully vaccinated. In March 2003, the Department of Health issued the following statement, None of the childhood vaccinations available in the UK are compulsory. They are offered on a voluntary basis. There are no plans to alter this policy.

These issues were once again debated by the British Medical Association (BMA) earlier this year, and once again, UK doctors voted against making vaccinations compulsory in the UK.

In a recent article discussing the BMAs decision, the Daily Mail stated that:

Doctors leaders have rejected the id...

21:20

Agent Orange: 24 Chilling Photographs of the War Crime the U.S. Govt. Got Away With "IndyWatch Feed Health"

Source: Agent Orange: 24 Chilling Photographs of the War Crime the U.S. Govt. Got Away With For more content like this visit REALfarmacy.com.

For ten years during the Vietnam War, the United States used a toxic concoction of two herbicides, labeled Agent Orange, to wipe out large areas of Vietnam which were covered by thick jungle. The aim was to enable easier and more effective bombing of enemy bases. The issue was, Agent Orange wasnt just an herbicide []

Source: Agent Orange: 24 Chilling Photographs of the War Crime the U.S. Govt. Got Away With Learn more at REALfarmacy.com - Healthy News and Information.

21:18

Red ginseng extract could be used to reduce the fermentation time of yogurt and enhance its antioxidant capacity. "IndyWatch Feed Health"

PMID:  Korean J Food Sci Anim Resour. 2016 ;36(3):412-20. Epub 2016 Jun 30. PMID: 27433113 Abstract Title:  Physicochemical Characteristics and Antioxidant Capacity in Yogurt Fortified with Red Ginseng Extract. Abstract:  The objective of this study was to investigate characteristics and functionality of yogurt applied red ginseng extract. Yogurts added with red ginseng extract (0.5, 1, 1.5, and 2%) were produced using Lactobacillus acidophilus and Streptococcus thermophilus and stored at refrigerated temperature. During fermentation, pH was decreased whereas titratable aicidity and viable cell counts of L. acidophilus and S. thermophilus were increased. The composition of yogurt samples was measured on day 1, an increase of red ginseng extract content in yogurt resulted in an increase in lactose, protein, total solids, and ash content, whereas fat and moisture content decreased. The pH value and cell counts of L. acidophilus and S. thermophilus were declined, however titratable acidity was increased during storage period. The antioxidant capacity was measured as diverse methods. During refrigerated storage time, the value of antioxidant effect was decreased, however, yogurt fortified with red ginseng extract had higher capacity than plain yogurt. The antioxidant effect was improved in proportion to concentration of red ginseng extract. These data suggests that red ginseng extract could affect to reduce fermentation time of yogurt and enhance antioxidant capacity.

read more

21:06

First U.S. School District to Serve 100% Organic, GMO-Free Meals "IndyWatch Feed Health"

Source: First U.S. School District to Serve 100% Organic, GMO-Free Meals For more content like this visit REALfarmacy.com.

They are the first in the nation to serve their students 100 percent organic meals, sustainably sourced, and free of genetically modified organisms (GMOs). More than 500 students at Bayside MLK Jr. Academy in Marin City and Willow Creek Academy in Sausalito will eat fresh, local food year-round, thanks to a partnership with the Conscious Kitchen, []

Source: First U.S. School District to Serve 100% Organic, GMO-Free Meals Learn more at REALfarmacy.com - Healthy News and Information.

20:52

Moncton votes to keep fluoride out of water "IndyWatch Feed Health"

Eight months of lengthy discussions came to an end on Monday night when Moncton city council voted to stick to the status quo of not adding fluoride to the municipalitys water.

In 2011, after a contentious debate, Moncton council voted to suspend adding fluoride to the citys water for five years.

At the time, council asked the provincial Department of Health and the New Brunswick Dental Society to conduct a study on the benefits and risks of water fluoridation, which neither group did.

After a meeting with speakers representing both sides of the fluoride debate in June this year, and soliciting input from the public, staff recommended the city continue to not add fluoride to the Great Moncton water supply unless directed by the federal or provincial governments to do so.

Fluoridation has been widely studied and, if the fluoride doesnt exceed a particular level, is a tool endorsed by both higher levels of government for reducing tooth decay.

Coun. Pierre Boudreau moved the motion Monday night, expressing concern the city may be held legally responsible if any dangers were ever found to be associated with water fluoridation.

We should err on the side of caution, said Boudreau.

Boudreau said an expert report should be provided by the provincial government before council approves reinstating fluoride into the citys water. Coun. Shawn Crossman seconded the motion.

Mayor Dawn Arnold weighed in, saying the city had a responsibility to be thorough.

We need to be able to prove beyond a shadow of a doubt that we are doing no harm if we were to introduce this and thats a tough one to make, said Arnold.

[There] are simply too many questions and a lack of consistent scientific consensusis worrisome to me.

Fluoride supporters disappointed

After the meeting, Dentist, vocal fluoride supporter and Vice President of the New Brunswick Dental Society Susan Drapeau-McNally said if council refuses to protect the teeth of the citys disadvantaged citizens through fluoride, then it should start working on another way to bring dental hygiene to people who cant afford it.

I am very disappointed, said Drapea...

20:52

Korean red ginseng ameliorated the devastating effects of Epididymo-orchitis on the sperm retrieved from either epididymis or testicle in rats. "IndyWatch Feed Health"

PMID:  Cell J. 2016 ;18(3):446-57. Epub 2016 Aug 24. PMID: 27602327 Abstract Title:  Ameliorating Effect of Ginseng on Epididymo-Orchitis Inducing Alterations in Sperm Quality and Spermatogenic Cells Apoptosis following Infection by Uropathogenic Escherichia coli in Rats. Abstract:  OBJECTIVE: Epididymo-orchitis (EO) potentially results in reduced fertility in up to 60% of affected patients. The anti-inflammatory effects of Korean red ginseng (KRG) and its ability to act as an immunoenhancer in parallel with the beneficial effects of this ancient herbal medicine on the reproductive systems of animals and humans led us to evaluate its protective effects against acute EO.MATERIALS AND METHODS: This animal experimental study was conducted in the Department of Anatomical Sciences, Faculty of Medicine, Zanjan University of Medical Sciences (ZUMS), Zanjan, Iran during 2013-2015. We divided 50 Wistar rats into five following groups (n=10 per group): i. Control-intact animals, ii. Vehicle-phosphate buffered saline (PBS) injection into the vas deferens, iii. KRG-an intraperitoneal (IP) injection of KRG, iv. EO-an injection of uropathogenic Escherichia coli (UPEC) strain M39 into the vas defer- ens, and v. EO/ KRG-injections of both UPEC strain M39 and KRG. The treatment lasted seven days. We then evaluated sperm parameters, number of germ cell layers, Johnson's criteria, germ cell apoptosis, body weight and relative sex organs weight.RESULTS: Acute EO increased the relative weight of prostate and seminal vesicles (P0.05). It also reduced sperm quality such as total motility, sperm concentration (P0.01), and the percentage of normal sperm (P0.001). Moreover, acute EO decreased Miller's (P0.05) and Johnsen's scores and increased apoptotic indexes of spermatogenic cells (P0.001). KRG treatment decreased prostate weight gain (P0.05) and improved the percentage of sperm with normal morphology, total motility (P0.01), and progressive motility (P0.05). The apoptotic indexes of spermatogenic cells reduced (P0.001), whereas both Johnsen's (P0.01) and Miller's criteria increased in the KRG-treated EO testis (P0.05).CONCLUSION: Consequently, KRG ameliorated the devastating effects of EO on the sperm retrieved from either epididymis or testicle in rats.

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20:01

Long-term administration of Korean red ginseng water extract significantly delayed the aging-induced testicular dysfunction. "IndyWatch Feed Health"

PMID:  Exp Gerontol. 2017 Apr ;90:26-33. Epub 2017 Jan 23. PMID: 28126553 Abstract Title:  Korean red ginseng improves testicular ineffectiveness in aging rats by modulating spermatogenesis-related molecules. Abstract:  Korean red ginseng (Panax ginseng Meyer) is known to rejuvenate testicular effectiveness and the sperm maturation process by regulating redox proteins in aged rats. This study was performed to investigate the effect of Korean red ginseng water extract (KRG-WE) on the expression level of spermatogenesis-related key biomolecules and sex hormone receptors as well as enzymes regulating oxidation, histone deacetylation, and growth-related activities in aged rat testis. KRG-WE (200mg/kg) mixed with a regular pellet diet was administered to 12-month-old rats for 6months (KRG-AC), whereas the young (YC, 2months) and aged (AC, 12months) controls received the vehicle only. The results showed that the expression levels of spermatogenesis-related key biomolecules (inhibin-, nectin-2, and cyclic adenosine monophosphate [cAMP] responsive element binding protein [CREB]-1), sex hormone receptors (androgen, luteinizing- and follicle-stimulating hormone receptors [AR, LHR, and FSHR, respectively]), and antioxidant enzymes (glutathione S-transferase mu [GSTm]-5, glutathione peroxidase [GPx]-4, peroxiredoxin [PRx]-3), as well as histone deactylation (silent mating type information regulation 2 homolog 1, SIRT1) and growth-related (mammalian target of rapamycin complex 1, mTORC1) molecules were significantly altered in the AC group rat testes compared with those of the YC group. However, KRG-WE treatment of the AC group significantly (p

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19:02

Language of Mental Illness Others People: Its a Human Rights Violation "IndyWatch Feed Health"

To separate out the sensitive and call them mentally ill is yet another disservice and retraumatization to our most sensitive citizens. Seriously. We need to cut it out.

Becoming conscious is risky business.

The language of mental illness others people and is a human rights violation committed mindlessly by our entire culture. Forced treatment is the most obvious violence against us but microaggressions happen daily everywhere.

When separation and microaggressions are legitimized and put into public policy and discourse the way its been done, we become second class citizens and subhumans and its all very acceptable as far as most are concerned.

This is an energetic reality whether people are aware of it or not. This is oppression and bigotry systemically supported and then denied by almost everyone, including those most seriously affected. We internalize it and come to believe these lies.

Just like racism and yet, its not recognized yet (not widely certainly there are those who fight for broad systemic change who do get it, but we are a tiny minority at this point).

Mentally ill is a slur for those with the greatest sensitivities to the harmful conditioning we all face and are subject to. We might say that Everyone is Mentally Ill and that some of us who are labeled as such and thus ostracized by these labels are actually the least in denial about what is happening to us and to our planet.

So yes, those of us labeled mentally ill are often closer to sanity than most of society. Language matters here and calling the most vulnerable among us mentally ill as though everyone isnt seriously affected is a form of doublespeak. Very 1984. A manipulation that helps people remain deep in denial so that we can keep on committing atrocities against one another and the planet. Everyone is Mentally Ill (yes, conditioned to the point of soul-loss) in this society, and those of us labeled are often far less so even though many of us may not yet be aware of this reality. See also: The Purpose of Life and the Human Conditioning.

It is no measure of health to be well-adjusted to a sick society. Krishnamurti

I get that its useful to use the language of illness for folks who attach to the illness construct as well so that we mi...

18:52

Scientists And Physicians Send Appeal About 5G Rollout And Health Dangers To The European Union "IndyWatch Feed Health"

By Catherine J. Frompovich

On September 13, 2017, more than 180 scientists and doctors sent an 11-page Appeal for a moratorium on the roll out of 5G in the European Union.

The reason for the appeal is RF/EMF has been proven to be harmful for humans and the environment, but 5G has not been investigated fully for potential health hazards and environmental impact by INDEPENDENT scientists, rather than industry scientists who apparently would rubber stamp 5G similarly as the other generations of telecommunications updates have been.

According to the Appeal, 5G is effective only over short distances and is transmitted poorly through solid materials. Because of that inefficiency in transmission, a tremendous number of antennas or cell towers will be needed to implement 5G service.

One key paragraph jumped out for me:

With the ever more extensive use of wireless technologies, nobody can avoid to be exposed. Because on top of the increased number of 5G-transmitters (even within housing, shops and in hospitals) according to estimates, 10 to 20 billion connections (to refrigerators, washing machines, surveillance cameras, self-driving cars and buses, etc.) will be parts of the Internet of Things. All these together can cause a substantial increase in the total, long term RF-EMF exposure to all EU citizens. [CJF emphasis]

...

18:43

Plastic in Our Bodies "IndyWatch Feed Health"

Our Bodies Are Becoming Plastic



Story at-a-glance
  • Globally, 83 percent of tap water samples tested were found to contain tiny microplastic particles
  • In the U.S., 94 percent of tap water samples were found to contain plastic the most out of all the locations tested
  • Large quantities of microplastics are likely being transferred to agricultural land via sewage sludge


By Dr. Mercola
It was a sad day in October 2015 when researchers from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) announced they had detected plastic litter on the surface of Arctic waters.1 Greenland sharks and seabirds living in the area were already known to be eating the debris,2 but the appearance of 31 pieces of floating debris in an otherwise largely pristine environment painted a disturbing picture of pollution problems that will only get worse if the amounts of litter entering the oceans arent reduced.
With plastics now entering the farthest reaches of the globe, what does that mean for the environments where these pollutants are known to accumulate? Mismanaged waste is particularly problematic in China, Indonesia, Vietnam, Thailand and the Philippines, which together make up the top five countries for plastic pollution.3 In the U.S., one of the top waste-generating countries, littering is a major issue, especially in the form of single-use plastics, like soda bottles, drinking straws and potato chip bags...

18:31

Saponin extracts induced apoptosis of endometrial cells from women with endometriosis. "IndyWatch Feed Health"

PMID:  Reprod Sci. 2017 Jan 1:1933719117711263. Epub 2017 Jan 1. PMID: 28558522 Abstract Title:  Saponin Extracts Induced Apoptosis of Endometrial Cells From Women With Endometriosis Through Modulation of miR-21-5p. Abstract:  Among the several components in Korean red ginseng, the saponin components are known to have various pharmacologic activities. The objective of this study was to evaluate therapeutic effects of saponin extracts from Korean red ginseng on endometriosis and to identify microRNAs (miRNAs) associated with saponin treatment. This is an in vitro study which used human endometrial stromal cells (HESCs) obtained from patients who underwent laparoscopic surgery for endometriosis and other benign conditions. Human endometrial stromal cells were treated with saponin extracts, and microarray profiling was performed. Human endometrial stromal cells were then transfected with miRNAs identified in the profiling. After the saponin extract treatment, the expression of caspase 3 was significantly increased in HESCs. Microarray profiling revealed several miRNAs that were differentially expressed, and miR-21-5p was further validated. Expression of miR-21-5p was significantly upregulated in the endometrium of patients with endometriosis, compared with controls. Transfection of a miR-21-5p inhibitor significantly increased caspase 3 expression in HESCs. The apoptotic potential of saponin extracts and the miR-21-5p inhibitor were further validated in HESCs using flow cytometry analysis. In conclusions, treatment with saponin extracts significantly decreased the expression of miR-21-5p in HESCs from patients with endometriosis. Inhibition of miR-21-5p effectively increased the apoptotic potential of HESCs. These findings suggest that saponin extract treatment may have therapeutic potential for endometriosis via modulation of specific miRNAs.

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18:22

Health Disparity Project Cuts Out the Recovery Movement "IndyWatch Feed Health"

NAMI Kansas ignoring the social determinants of health in their health disparity program design.

17:00

Another retraction hits high-profile food researcher under fire "IndyWatch Feed Health"

Its been a rough year for Brian Wansink. Last year, the prominent food researcher posted a blog praising a student for her productivity in his lab. But when Wansink described his methods, readers became concerned that the lab was using improper research techniques to generate more publications. Earlier this year, researchers posted an analysis of []

The post Another retraction hits high-profile food researcher under fire appeared first on Retraction Watch.

16:52

CDC Study Shows Up to 7.7 Times the Risk of Miscarriage After Influenza Vaccine "IndyWatch Feed Health"

By Robert F. Kennedy, Jr.

The CDC has just published a seismic study (Donahue et al. 2017 Vaccine 35:5314) linking spontaneous abortions in women to flu vaccines.  The study reviewed data for the 2010-11 and 2011-12 flu seasons.  Women vaccinated with the inactivated influenza vaccine (IIV) in the 2010-2011 season were 3.7 times more likely to experience a spontaneous abortion within 28 days than women not receiving the vaccine.  Over the entire study period (2010 to 2012), the odds for a spontaneous abortion for vaccinated women were 2.0 times greater than for those women not receiving the flu vaccine.  Both figures showed a statistically significant increase in miscarriages when women received their flu shot.  Most alarmingly, in women who received the H1N1 vaccine in the previous flu season, the odds of spontaneous abortion in the 28 days after receiving a flu vaccine was 7.7 times greater.

The vast majority of these flu vaccines were multi-dose formulations, containing 25 micrograms of mercury via the preservative thimerosal.  In those years, out of approximately 150 million flu shots given in the U.S. annually, less than 50 million or 34% of those vaccines available for pregnant women were thimerosal-free.

For many years, health officials have warned pregnant women to avoid eating mercury-containing tuna. And, even before this latest study, some government scientists were questioning the wisdom of pressuring women to receive mercury-laden flu shots in any trimester of pregnancy.  National Toxicology Program Deputy Director, Dr. George Lucier, said The developing fetus should NEVER be exposed to any amount of mercury, period!  In the words of senior CDC epidemiologist, Dr. William Thompson, So I dont know why they still give it [the flu shot] to pregnant women, like thats the last person I would give mercury to.

vaccine manufacturers acknowledge that flu vaccines have never been shown to be safe for pregnant women.

CDC officially claims that thimerosal is the safe mercury because it is purportedly excreted quickly from the body.  CDC bases this claim solely on its misinterpretation of data from a poorly designed study conducted in the early 2000s by an industry insider, Dr. Michael Pichichero. Subsequent studies have proven that the ethylmercury in thimerosal is actually far more persistent in organs than the methylmercury in fish (Burbacher et al. 2005 Environ Health Perspect. 113:1015) (Rodrigues et al. Arch Toxicol. 201...

15:48

Higher levels of fluoride in urine associated with lower intelligence in children "IndyWatch Feed Health"

Fluoride in the urine of pregnant women shows a correlation with lower measures of intelligence in their children, according to University of Toronto researchers who conducted the first study of its kind and size to examine fluoride exposure and multiple states of neurodevelopment.

Our study shows that the growing fetal nervous system may be adversely affected by higher levels of fluoride exposure, said Dr. Howard Hu, the studys principal investigator and Professor of Environmental Health, Epidemiology and Global Health at the Dalla Lana School of Public Health. It also suggests that the pre-natal nervous system may be more sensitive to fluoride compared to that of school-aged children.

Tap water and dental products have been fluoridated in communities in Canada and the United States (as well as milk and table salt in some other countries) by varying amounts for more than 60 years to prevent cavities and improve bone health. In recent years, fierce debate over the safety of water fluoridation particularly for childrens developing brains has fueled researchers to explore the issue and provide evidence to inform national drinking water standards.

There are some known side effects of fluoride, for example dental defects like mild staining are common among those ingesting recommended levels of fluoride in the United States and Canada. Skeletal fluorosis excessive accumulation of fluoride in the bones is much less common and only observed at levels of fluoride in the water that are more than 5 to 10 times higher than those recommended.

Relatively little is known, with confidence, about fluorides impact on neurodevelopment, said Hu, whose research team included experts from the National Institute of Public Health of Mexico, University of Toronto, University of Michigan, McGill University, Indiana University, Mount Sinai School of Medicine and Harvard School of Public Health.

The study, Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6-12 Years of Age in Mexico, published today in Environmental Health Perspectives, analyzed data from 287 mother-child pairs in Mexico City that were part of the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project, which recruited pregnant women from 1994 to 2005 and has continued to follow the women and their children ever since.

The research team analyzed urine samples that had been taken from mothers during pregnancy and from their children between six and 12 years of age to reconstruct personal measures of fluoride exposure for both mother and...

15:45

UN Endorsed California Governor Jerry Brown Expected to Decriminalize HIV+ Blood Donors "IndyWatch Feed Health"

According to Governor Browns website, Governor Edmund G. Brown Jr. was named Special Advisor for States and Regions ahead of this years United Nations Climate Change Conference (COP 23) by the Prime Minister of Fiji Frank Bainimarama incoming president of COP 23 today at a ceremony where Fiji became the latest government to Continue reading UN Endorsed California Governor Jerry Brown Expected to Decriminalize HIV+ Blood Donors

The post UN Endorsed California Governor Jerry Brown Expected to Decriminalize HIV+ Blood Donors appeared first on BolenReport.

15:13

Canadian Study Claims Autism-Aluminum Adjuvant Link Confirmed "IndyWatch Feed Health"

Two weeks ago, a French study raised concerns regarding the aluminum used in vaccines. Concerns about its [aluminum adjuvants] safety emerged following recognition of its unexpectedly long-lasting biopersistence within immune cells in some individuals, and...

The post Canadian Study Claims Autism-Aluminum Adjuvant Link Confirmed appeared first on Vaxxter.

14:00

Article defending colonialism draws rebuke, journal defends choice to publish "IndyWatch Feed Health"

Facing a volley of criticism for publishing an essay that called for a return to colonialism, a journal editor has defended his decision to print the article. The Case for Colonialism, published Sept. 8 in Third World Quarterly (TWQ), was written by Bruce Gilley, a professor of political science at Portland State University. For an []

The post Article defending colonialism draws rebuke, journal defends choice to publish appeared first on Retraction Watch.

14:00

Autism Birthday Agony: Attitude Adjusted "IndyWatch Feed Health"

September 19, 2017 As my sons birthday rolls around again this year, I am reminded of the mindset I had just two years ago when Shia turned five. I woke up heavy hearted on his fifth birthday.  I remember being Continue reading

The post Autism Birthday Agony: Attitude Adjusted appeared first on The Thinking Moms' Revolution.

12:03

New Tool to Assess Usefulness of Clinical Guidelines "IndyWatch Feed Health"

From Medical Xpress: A new tool, G-TRUST (the Guideline Trustworthiness, Relevance, and Utility Scoring Tool) has been developed to help clinicians assess the usefulness of clinical guidelines in their treatment of patients.

In every medical specialty, physicians are required to review multiple sets of practice guidelines to determine their usefulness for a specific patients treatment. Such tools are often developed primarily for research and further guideline development rather than direct clinical application, said first and corresponding author Allen Shaughnessy, Pharm.D., M.Med.Ed., professor at Tufts University School of Medicine and fellowship director of the Tufts University Family Medicine Residency Program at Cambridge Health Alliance.

As an aid to practicing clinicians, the research team developed a straightforward eight-point tool for scoring clinical guidelines to assess their usefulness that can be applied in a clinical setting.

Article

12:02

Lawsuit Over a Suicide Points to a Risk of Antidepressants "IndyWatch Feed Health"

From The New York Times: The recent trial of Wendy Dolin, whose husband died of suicide after starting the antidepressant paroxetine, demonstrates our need for more understanding and awareness of the risks of antidepressants.

Article

12:01

APA to Release Guidelines for Fat-Shaming Kids for Profit "IndyWatch Feed Health"

From Ravishly: The American Psychological Association has released a draft of their Clinical Practice Guideline for the Behavioral Treatment of Obesity and Overweight in Children and Adolescents. These guidelines promote fat-shaming and sizeism directed at young people and could potentially lead to disordered eating and trauma.

these guidelines dont appear to have anything to do with helping people who need psychological treatment. It seems to me that somebody finally told the APA how much money the fat phobia industry makes for those who claim (however dubiously) that they can make fat people thin and, despite what well soon find is an astounding lack of evidence, the APA and its members want their piece of that anti-obesity money pie.

They acknowledge that there is tremendous stigma directed toward kids with larger bodies, but they are using that to back up their assertion that fat kids should get treatment to become thin. So the APA is basically suggesting that fat kids acquiesce to their bullies. As a queer woman, I see this logic and wonder if they are suggesting that queer kids who get bullied have reparative therapy to try to become straight (which, like weight loss attempts, is highly unlikely to work and can do physical and mental harm).

Article

09:00

Flu Shots: Here We Go Again! "IndyWatch Feed Health"

The many myths about flu shots continue to circulate and persuade some people not to get a flu shot. Flu shots are excellent insurance, safe and reasonably effective. Immunization protects not only the recipient but also vulnerable groups in the community.

07:00

High Cost of Corn and Saving Prairies "IndyWatch Feed Health"

By Dr. Mercola

Take a drive through the U.S. Midwest and you cant miss the seemingly endless fields of corn. Depending on the season, the corn may be tall and green or dry and brown, or even already plowed, leaving vast swatches of barren soil exposed. None of the scenarios would appear particularly noteworthy to the average passerby, and certainly not cause for alarm.

However, if you dig a bit deeper into the reality of not just the U.S. Corn Belt, but also the massive amounts of corn being grown around the globe, a darker picture begins to emerge. Gone are the days of small-town farmers growing just enough corn to feed locals and, perhaps, their livestock over the winter.

In the 21st century, the two major consumers of corn are industrial in nature: concentrated animal feeding operations (CAFOs) and ethanol. Theres now so much corn grown in the U.S. that the Corn Belt (typically said to include corn grown across Indiana, Illinois, Iowa, Missouri and parts of Nebraska and Kansas) can be seen from space, courtesy of satellite chlorophyll-sensors.1

Theres a tendency to think of corn as natural and even all-American, but as its true environmental costs become clear growing corn is not only chemical-intensive but also requires significant amounts of water and land, leading to air pollution, water scarcity and more accountability is becoming more important.

Where in the Supply Chain Is Corn Causing the Most Environmental Harm?

A study published in Proceedings of the National Academy of Sciences tackled the monumental task of figuring out which U.S. counties produced the most corn as well as where that corn ended up downstream, right down to the various supply chains and industries.2 Think of the new research as a computer model of the United States of Corn, Bloomberg reported, continuing:3

The general problem that the researchers took on prompted by a collaboration with the nongovernmental organization the Environmental Defense Fund (EDF) is that some 75 percent of the carbon dioxide emissions and water use of economic production is bound up in an enormous, poorly documented network of supply chains.

Given the importan...

How University Foundations Circumvent Conflict of Interest Disclosure Rules and Hide Corporate Ties to Faculty "IndyWatch Feed Health"

By Dr. Mercola

In the last few years, freedom of information act (FOIA) requests have revealed a loophole that allows corporations to hide funds given to university-based researchers and academics, thereby also hiding their behind-the-scenes collaborations to promote corporate viewpoints while maintaining an air of independence. A recent defamation suit offers an intriguing opportunity to shed even more light on this, what appears to be, common practice.

FOIA Documents Revealed Professor's Big Ag Links

Kevin Folta a plant scientist and professor at the University of Florida and an outspoken advocate of genetic engineering became a posterchild for this kind of disclosure avoidance when, two years ago, a FOIA request by the California-based activist group US Right to Know (USRTK) produced correspondence revealing Folta had instructed Monsanto on how to avoid disclosing funding his work by depositing the money into the university's SHARE (Special Help for Agricultural Research and Education) contribution account.

As noted by Folta in his proposal to Monsanto,1 "a SHARE contribution is not subject to IDC and is not in a conflict-of-interest account. In other words, SHARE contributions are not publicly noted. This eliminates the potential concern of the funding organization influencing the message." Put another way, by making a SHARE contribution, the link between Folta and Monsanto would remain hidden, and his public promotion of biotech would not be tainted by obvious suspicions of conflicts of interest.

This is one of the biggest scams going. Universities have very strict conflict of interest rules in place, all of which are effectively circumvented by giving the funds as a grant to the University of Florida Foundation, which operates as a separate, non-public entity. The foundation then issues the money to individual researchers' programs. Yet, even though the money can be easily earmarked for a specific individual or program, financial contributions to the foundation do not need to be publicly disclosed.

While this loophole is news for many, evidence suggests researchers and academics have routinely used it to avoid conflicts of interest disclosure rules. Bruce Chassy was caught doing the same thing. An investigation by Chicago WBEZ news discovered Monsanto paid the now retired University of Illinois' professor more than $57,000 over two years for travel, writing and speaking expenses, yet Chassy never disclosed his financial ties to the comp...

Our Bodies Are Becoming Plastic "IndyWatch Feed Health"

By Dr. Mercola

It was a sad day in October 2015 when researchers from the Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research (AWI) announced they had detected plastic litter on the surface of Arctic waters.1 Greenland sharks and seabirds living in the area were already known to be eating the debris,2 but the appearance of 31 pieces of floating debris in an otherwise largely pristine environment painted a disturbing picture of pollution problems that will only get worse if the amounts of litter entering the oceans arent reduced.

With plastics now entering the farthest reaches of the globe, what does that mean for the environments where these pollutants are known to accumulate? Mismanaged waste is particularly problematic in China, Indonesia, Vietnam, Thailand and the Philippines, which together make up the top five countries for plastic pollution.3 In the U.S., one of the top waste-generating countries, littering is a major issue, especially in the form of single-use plastics, like soda bottles, drinking straws and potato chip bags.

According to environmental advocacy group Ocean Conservancy, some plastic products persist for so long, even in salty ocean water, that theyll still be recognizable after 400 years.4 However, an equally alarming problem is the plastics that do get broken down into tiny pieces. Microplastic particles, which are less than 5 millimeters long, are literally clouding the oceans in spots.

Carried along with the oceans currents, swirling gyres of plastic smog5 now cover about 40 percent of the worlds ocean surfaces.6 Theyre being eaten by fish and other marine life that is well-known. But only recently did researchers take the logical next step to determine that its not only marine life ingesting plastic you probably are too.

94 Percent of US Tap Water Contains Plastic Fibers

Research commissioned by media outlet Orb revealed alarming data about plastic pollution in tap water,...

06:00

Debut Day For Vaccines: A Reappraisal by Dr. Richard Moskowitz from Skyhorse Publishing "IndyWatch Feed Health"

Congratulations to Dr. Moskowitz on the debut of his new book Vaccine Reappraisal from Skyhorse Publishing at #1 in Vaccinations. Mary Holland wrote the foreword. Order your hardcover or Kindle edition today and don't forget to leave a review at...

03:35

The Thriving Child Summit FREE Online! "IndyWatch Feed Health"

Thriving Child Summit

The Thriving Child Summit is a FREE online conference for parents who want to learn how to help their children THRIVE!

Health Impact News

Join holistic mama doc Elisa Song, MD, for this inspirational, information-packed, 1-week event where she brings you video interviews with over 40 of the worlds leading experts in holistic health and wellness, integrative medicine, nutrition, parenting, and mind-body medicine who will show you how to help your children thrive to their fullest potentials.

Whether your child is healthy, or has a chronic health concern learn how to integrate the best of conventional and holistic pediatric health care, lifestyle management, and parenting tools.

Become empowered to take charge of your childs health and wellness holistically!

The Thriving Child Summit is for YOU if you want to learn:

  • The foundations for optimal childrens health.
  • What to feed your kids (or avoid!) to nourish their bodies and brains.
  • How to use natural medicines to avoid antibiotics and keep your child healthy.
  • The truth about EMFs, GMOs, pesticides, heavy metals, and other toxins and how to keep your kids healthy in our toxic world.
  • How to find the root cause and heal your childs leaky gut, anxiety/depression, ADHD, autism, PANDAS/PANS, eczema, acne, and other chronic illnesses.
  • The truth about vaccine safety from two board-certified pediatricians.
  • How to talk to kids about puberty, stress management and social media so that theyll actually listen!
  • How to trauma-proof your child and create resilient kids for a lifetime.
  • How genetics really plays a role in the future of your or your childs health.
  • How to reclaim your mama vitality.
  • And more!

...

03:31

The Thriving Child Summit FREE Online! "IndyWatch Feed Health"

Thriving Child Summit

The Thriving Child Summit is a FREE online conference for parents who want to learn how to help their children THRIVE!

Health Impact News

Join holistic mama doc Elisa Song, MD, for this inspirational, information-packed, 1-week event where she brings you video interviews with over 40 of the worlds leading experts in holistic health and wellness, integrative medicine, nutrition, parenting, and mind-body medicine who will show you how to help your children thrive to their fullest potentials.

Whether your child is healthy, or has a chronic health concern learn how to integrate the best of conventional and holistic pediatric health care, lifestyle management, and parenting tools.

Become empowered to take charge of your childs health and wellness holistically!

The Thriving Child Summit is for YOU if you want to learn:

  • The foundations for optimal childrens health.
  • What to feed your kids (or avoid!) to nourish their bodies and brains.
  • How to use natural medicines to avoid antibiotics and keep your child healthy.
  • The truth about EMFs, GMOs, pesticides, heavy metals, and other toxins and how to keep your kids healthy in our toxic world.
  • How to find the root cause and heal your childs leaky gut, anxiety/depression, ADHD, autism, PANDAS/PANS, eczema, acne, and other chronic illnesses.
  • The truth about vaccine safety from two board-certified pediatricians.
  • How to talk to kids about puberty, stress management and social media so that theyll actually listen!
  • How to trauma-proof your child and create resilient kids for a lifetime.
  • How genetics really plays a role in the future of your or your childs health.
  • How to reclaim your mama vitality.
  • And more!

...

03:27

The Thriving Child Summit FREE Online! "IndyWatch Feed Health"

Thriving Child Summit

The Thriving Child Summit is a FREE online conference for parents who want to learn how to help their children THRIVE!

Health Impact News

Join holistic mama doc Elisa Song, MD, for this inspirational, information-packed, 1-week event where she brings you video interviews with over 40 of the worlds leading experts in holistic health and wellness, integrative medicine, nutrition, parenting, and mind-body medicine who will show you how to help your children thrive to their fullest potentials.

Whether your child is healthy, or has a chronic health concern learn how to integrate the best of conventional and holistic pediatric health care, lifestyle management, and parenting tools.

Become empowered to take charge of your childs health and wellness holistically!

The Thriving Child Summit is for YOU if you want to learn:

  • The foundations for optimal childrens health.
  • What to feed your kids (or avoid!) to nourish their bodies and brains.
  • How to use natural medicines to avoid antibiotics and keep your child healthy.
  • The truth about EMFs, GMOs, pesticides, heavy metals, and other toxins and how to keep your kids healthy in our toxic world.
  • How to find the root cause and heal your childs leaky gut, anxiety/depression, ADHD, autism, PANDAS/PANS, eczema, acne, and other chronic illnesses.
  • The truth about vaccine safety from two board-certified pediatricians.
  • How to talk to kids about puberty, stress management and social media so that theyll actually listen!
  • How to trauma-proof your child and create resilient kids for a lifetime.
  • How genetics really plays a role in the future of your or your childs health.
  • How to reclaim your mama vitality.
  • And more!

...

02:24

Dara Berger at Health Choice Connecticut Rally "IndyWatch Feed Health"

NOTE: Below is Dara Berger's speech at the Health Choice CT rally on September 15. By Dara Berger My name is Dara Berger. I am an author of the book How to Prevent Autism and a documentary filmmaker. The most...

02:23

The Medicines and Healthcare Products Regulatory Agency "IndyWatch Feed Health"

Note: We're delighted to share this post by Martin Walker. Martin covered the GMC trial in the UK moment by moment and is a copious author whose book "Dirty Medicine" is sharp and thought provoking. Please visit his website Slingshot...

02:18

There exists strong evidence from animal models suggesting pomegranate juice can be used to effectively treat IBD, and chronic inflammatory diseases. "IndyWatch Feed Health"

PMID:  Nutrients. 2017 Aug 30 ;9(9). Epub 2017 Aug 30. PMID: 28867799 Abstract Title:  Could Pomegranate Juice Help in the Control of Inflammatory Diseases? Abstract:  Fruits rich in polyphenols, such as pomegranates, have been shown to have health benefits relating to their antioxidant and anti-inflammatory properties. Using data obtained from PubMed and Scopus, this article provides a brief overview of the therapeutic effects of pomegranate on chronic inflammatory diseases (CID) such as inflammatory bowel disease (IBD), rheumatoid arthritis (RA), metabolic and cardiovascular disorders, and other inflammatory-associated conditions, with an emphasis on fruit-derived juices. Most studies regarding the effects of pomegranate juice have focused on its ability to treat prostate cancer, diabetes, and atherosclerosis. However, pomegranate juice has shown therapeutic potential for many other illnesses. For instance, a small number of human clinical trials have highlighted the positive effects of pomegranate juice and extract consumption on cardiovascular health. The beneficial effects of pomegranate components have also been observed in animal models for respiratory diseases, RA, neurodegenerative disease, and hyperlipidaemia. Furthermore, there exists strong evidence from rodent models suggesting that pomegranate juice can be used to effectively treat IBD, and as an anti-inflammatory agent to treat CID. The effects of pomegranate intake should be further investigated by conducting larger and more well-defined human trials.

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01:50

The results of this study suggest protective effects of pomegranate juice against myocardial ischemia and reperfusion injury. "IndyWatch Feed Health"

PMID:  Phytother Res. 2017 Sep 15. Epub 2017 Sep 15. PMID: 28913846 Abstract Title:  Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease. Abstract:  Ischemic heart disease is the leading cause of mortality worldwide. The purpose of this study was to evaluate the cardioprotective effects of pomegranate juice in patients with ischemic heart disease. One hundred patients, diagnosed with unstable angina or myocardial infarction, were randomly assigned to the test and the control groups (n = 50, each). During 5 days of hospitalization, in addition to the conventional medical therapies, the test groups received 220 mL pomegranate juice, daily. During the hospitalization period, the blood pressure, heart rate, as well as the intensity, occurrence, and duration of the angina were evaluated on a regular basis. At the end of the hospitalization period, the serum levels of malondialdehyde, interleukin-6, and tumor necrosis factor alpha were measured in all patients. The levels of serum troponin and high-sensitive C-reactive protein levels were also assayed in patients diagnosed with myocardial infarction. Pomegranate juice caused significant reductions in the intensity, occurrence, and duration of angina pectoris in patients with unstable angina. Consistently, the test patients had significantly lower levels of serum troponin and malondialdehyde. Other studied parameters did not change significantly. The results of this study suggest protective effects of pomegranate juice against myocardial ischemia and reperfusion injury. Copyright 2017 John Wiley&Sons, Ltd.

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00:45

Polysaccharides from Acanthopanax senticosus enhances intestinal integrity in lipopolysaccharide-challenged mice. "IndyWatch Feed Health"

PMID:  Anim Sci J. 2016 Aug ;87(8):1011-8. Epub 2015 Oct 5. PMID: 26435041 Abstract Title:  Polysaccharides from Acanthopanax senticosus enhances intestinal integrity through inhibiting TLR4/NF-B signaling pathways in lipopolysaccharide-challenged mice. Abstract:  To investigate the role of polysaccharide from Acanthopanax senticosus (ASPS) on lipopolysaccharide (LPS)-induced intestinal injury, mice in three treatments were administrated orally with or without ASPS (300 mg/kg body weight) for 14 days, followed by challenge with LPS or saline. At 4 h post-injection, blood and intestinal samples of six mice / treatment were collected. The results showed ASPS ameliorated LPS-induced intestinal morphological deterioration, proven by improved villus height (P

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00:20

Acanthopanax senticosus leaves could promote beneficial health effects including the prevention of metabolic syndrome. "IndyWatch Feed Health"

PMID:  J Sci Food Agric. 2016 Aug ;96(11):3717-22. Epub 2016 Feb 3. PMID: 26676315 Abstract Title:  Antihyperlipidemic effect of Acanthopanax senticosus (Rupr. et Maxim) Harms leaves in high-fat-diet fed mice. Abstract:  BACKGROUND: Metabolic syndrome is a major risk factor for a variety of obesity-related diseases. Recently, the effects of functional foods have been investigated on lipid metabolism as a means to reduce lipid content in the blood, liver and adipose tissues associated with carnitine O-palmitoyltransferase (CPT) activity. Acanthopanax senticosus (Rupr. et Maxim) Harms (AS) is a medicinal herb possessing a wide spectra of functions including antioxidant, anti-inflammatory and anti-fatigue actions. Despite much research being focused on the cortical roots of AS, little information is available regarding its leaves, which are also expected to promote human health, for example by improving abnormal lipid metabolism. Here, we explored whether AS leaves affect lipid metabolism in mice fed a high-fat diet.RESULTS: The administration of AS to BALB/c mice fed a high-fat diet significantly decreased plasma triglycerides (TG). CPT activity in the liver of these mice was significantly enhanced by AS treatment.CONCLUSION: These findings indicate that AS leaves have the potential to alleviate increase in plasma TG levels due to high-fat diet intake in mice, possibly by increasing mitochondrial fatty acid-oxidation, especially via CPT activation. Consequently, daily intake of AS leaves could promote beneficial health effects including the prevention of metabolic syndrome. 2015 Society of Chemical Industry.

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00:09

A. senticosus exhibited a potential for inhibition of histone deacetylase. "IndyWatch Feed Health"

PMID:  Exp Hematol. 2016 Jun ;44(6):466-73. Epub 2016 Mar 15. PMID: 26992299 Abstract Title:  A preliminary study on epigenetic regulation of Acanthopanax senticosus in leukemia cell lines. Abstract:  Conventional chemotherapy for leukemia inevitably causes systemic toxicity. Acanthopanax senticosus, a naturally occurring herb used in traditional Chinese medicine, has been found to be a multipotent bioflavonoid with great potential in the prevention and treatment of malignant diseases. However, the mechanism underlying the action of A. senticosus in epigenetic regulation is poorly understood. In the study described here, we focused on the efficacy of A. senticosus in inducing apoptosis of leukemia cells and a possible mechanism. By evaluating the inhibition ratio and morphologic changes, we found that A. senticosus can inhibit growth and induce apoptosis of human leukemia HL-60 and HL60/ADM cells in a dose- and time-dependent manner. Furthermore,A. senticosus induced Fas ligand (FasL) expression and blocked the cell cycle in S phase. In addition, A. senticosus exhibited a potential for inhibition of histone deacetylase (HADC), which contributes to histone acetylation. It possibly resulted in the promotion of the expression of FasL. It is suggested that A. senticosus could be recognized as a new HDAC inhibitor which was able to reactivate aberrantly silenced genes. We discuss the clinical aspects of using A. senticosus for treatment of leukemia.

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23:44

Soluble polysaccharides from the root of Acanthopanax senticosus could inhibit proliferation and induce the apoptosis in HepG2 cells. "IndyWatch Feed Health"

PMID:  Pharmazie. 2016 Apr ;71(4):201-4. PMID: 27209700 Abstract Title:  Effects of Acanthopanax senticosus polysaccharide on the proliferation, apoptosis and cell cycle in human HepG2 cells. Abstract:  One water-soluble polysaccharide (ASPS), with four molecular weight distributions of 74, 3.8, 4.5, 2.3 x 10(4) Da, was isolated from the root of Acanthopanax senticosus and the yield was 4.8% (w/w). ASPS was composed of arabinose (51.4%), glucose (24.5%), galactose (10.2%), xylose (5.7) and galacturonic acid (4.9%). Effects of ASPS on the proliferation, apoptosis and Wnt/-catenin signaling pathway were investigated in human hepatocellular carcinoma cell line HepG2 cells. The study showed that ASPS could inhibit the proliferation, increase the apoptosis rate in HepG2 cells; meanwhile, ASPS could increase the proportion of cells in G0/G1 phase, decrease the proportion of cells in S phase and G2/M phase, and elevate the expression level of -catenin, C-myc and Cyclin D1 proteins in HepG2 cells. These results indicate that ASPS has a certain inhibition on the proliferation, can induce the apoptosis and G0/G1 phase arrest in HepG2 cells, and the mechanism may berelated to the inhibition of ASPS on the activation of Wnt/-catenin pathway HepG2 cells.

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23:28

7 Serious Infections from Contaminated Food and Water "IndyWatch Feed Health"

7 Serious Infections from Contaminated Food and Water

Just Hanging Out (and I mean just hanging out)

Just Hanging Out (and I mean just hanging out)

 

Recently, I watched a few episodes of Naked and Afraid, a series that puts two individuals in extreme environments with few supplies and, for some reason, no clothes. In this program, many of the participants come down with various infections; some of which cause bowel disturbances. Life then becomes, well, even more miserable than walking around for three weeks naked in the jungle.

Epidemics characterized by diarrhea and dehydration have been a part of the human experience since before recorded history. Cholera is an example of one particularly dangerous infection that was epidemic in the past. It and other bacterial diseases, many of which are now rare, may once again become a problem in the uncertain future.

Off the grid, water quality is questionable and may lead to misfortune if not properly purified. Using bad water to cook food in a remote setting can also lead to major problems that manifest as diarrhea, and later, dehydration. When dehydration is not treated, deaths may occur.

typical bacteria

typical bacteria

Many diseases with diarrhea as the main symptom are caused by poor sanitation. These including the following:

Cholera: Caused by CTX, a toxin produced by the marine and freshwater bacterium Vibrio cholera. Cholera toxins produce a rapid onset of diarrhea and vomiting within a few hours to 2 days of infection. This was a major issue in Haiti after the earthquake there several years ago.

The diarrhea caused by cholera looks like water after rice has been cooked in it. In addition, victims complain of nausea, leg cramps, and other symptoms. The body water loss with cholera is so severe that it is associated with a sixty per cent death rate if untreated. Aggressive efforts to rehydrate the patient, however, drops the death rate to only one pe...

23:23

Ceremonial ayahuasca drinking shows promise in the healing of eating disorders. "IndyWatch Feed Health"

PMID:  J Psychoactive Drugs. 2017 Sep 12:1-9. Epub 2017 Sep 12. PMID: 28895501 Abstract Title:  Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders. Abstract:  Eating disorders (EDs) are serious health conditions that are among the most difficult to treat. Innovative treatments are needed and modalities from across cultures must be considered. Ayahuasca is a psychoactive plant-based tea originally used by Amazonian indigenous groups. A growing body of research points to its promise in the healing of various mental health issues. This study explored the potential therapeutic value of ayahuasca in the context of EDs, including the perceived impact of the preparatory diet and the ayahuasca purge. Sixteen individuals previously diagnosed with an ED participated in a semi-structured interview relating to their experiences with ceremonial ayahuasca drinking. Interviews were analyzed using thematic analysis. Themes presented relate to the reduction or cessation of ED and mental health symptoms, shifts in body perception, and the importance of a ceremonial setting and after-care. For some, the preparatory diet resulted in familiar patterns of concern; however, none felt triggered by the purge in ayahuasca. Ceremonial ayahuasca drinking shows promise in the healing of EDs and warrants further research.

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23:03

Cannabidiol may be a safe and useful therapeutic agent for treating Osteoarthritis joint neuropathic pain. "IndyWatch Feed Health"

PMID:  Pain. 2017 Sep 1. Epub 2017 Sep 1. PMID: 28885454 Abstract Title:  Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis. Abstract:  Osteoarthritis (OA) is a multifactorial joint disease, which includes joint degeneration, intermittent inflammation, and peripheral neuropathy. Cannabidiol (CBD) is a non-euphoria producing constituent of cannabis that has the potential to relieve pain. The aim of this study was to determine if CBD is anti-nociceptive in OA, and whether inhibition of inflammation by CBD could prevent the development of OA pain and joint neuropathy. OA was induced in male Wistar rats (150-175g) by intra-articular injection of sodium monoiodoacetate (MIA; 3mg). On day 14 (end stage OA), joint afferent mechanosensitivity was assessed using in vivo electrophysiology while pain behaviour was measured by von Frey hair algesiometry and dynamic incapacitance. To investigate acute joint inflammation, blood flow and leukocyte trafficking were measured on day 1 post-MIA. Joint nerve myelination was calculated by G-ratio analysis. The therapeutic and prophylactic effects of peripheral CBD (100-300g) were assessed. In end stage OA, CBD dose-dependently decreased joint afferent firing rate, and increased withdrawal threshold and weight bearing (p

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22:07

How Hand-Washing Dishes Keeps Childrens Allergies Away and Boosts Immunity "IndyWatch Feed Health"

This article is shared with permission from our friends at ZME Science.  Heres another reason for children to do their chores: washing dishes by hand boosts childrens immune system. The findings were reported by Swedish doctors who found that in households where dishes are washed by hand children have much fewer...

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22:05

Scientific Evidence Explains Why Some Healers See the Aura of People "IndyWatch Feed Health"

This article is shared with permission from our friends at ZME Science.  You may call them healers, you may call them quacks, but a scientific study conducted in Spain has shown many of these people display a neuropsychological phenomenon known as synesthesia (specifically, emotional synesthesia), giving a valuable explanation of...

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22:04

Study Confirms Inflammation Causes Heart Disease Not Cholesterol "IndyWatch Feed Health"

heart and stethoscope laying on cardiologist working table

by Paul Fassa
Health Impact News

If you have been visiting Health Impact News, you may have noticed the notion that arterial inflammation is whats behind heart disease, not cholesterol from saturated fats.

A clinical human trial recently published in The New England Journal of Medicine in August of 2017 may tip a few more in the medical field into accepting the current awareness that inflammatory damage is a major cause of heart and cardiovascular disease, and cholesterol is trying to patch up the damage before the vessel begins to leak or rupture.

Cholesterol is actually a vitally useful waxy compound for many parts of our bodies, especially the brain. Lowering cholesterol is misguided, and usually causes terrible side effects.

Recent Novartis Pharmaceuticals Funded Study

Novartis Pharmaceuticals funded the original study titled Anti-inflammatory Therapy with Canakinumab for Atherosclerotic Disease.

Canakinumab is a drug with the brand name Illaris developed by Novartis to neutralize interleukin-1b. Interleukin-1 is a pro-inflammatory cytokine thats part of our natural immune system. But if its overproduced or becomes chronic, it results in increased inflammation throughout the body.

The current marker for inflammation is hsCRP, high-sensitivity C-reactive protein, which is produced by the liver when there is inflammation anywhere in the body. It is detected by testing for CRP with blood samples.

The Center for Cardiovascular Disease Prevention conducted a 48 month double blind placebo trial involving slightly over 10,000 heart patients covering 37 nations who had experienced at least one heart attack, technically know as a myocardial infarction, among whom all had high hsCRP readings.

The results were favorable for Novarti...

22:02

Neuroscientist Studies Dog Emotions with MRI, Concludes Dogs are People, Too "IndyWatch Feed Health"

This article is shared with permission from our friends at ZME Science. Most dog owners will tell you that their pets are awesome, and if you ask them if they think their dog loves them, most of the time youll be met with a positive answer. But do dogs feel love or...

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22:02

Robert F. Kennedy, Jr. Exposes New Evidence of CDC Corruption Regarding Vaccines and Autism "IndyWatch Feed Health"

CDC Fraud Corruption

Many of the CDC claims regarding a connection between vaccines and autism is based on fraudulent research.

Robert F. Kennedy, Jr. and World Mercury Project Issue Report Regarding New Evidence of Ongoing Corruption and Scientific Misconduct at CDC

Kennedy hopes new evidence and a fresh look at criminal misconduct will result in law enforcement action, rigorous and transparent vaccine safety science, and safer vaccines.

by World Mercury Project

FOR IMMEDIATE RELEASE, September 18, 2017
Contact: Lyn Redwood, 202-810-1826,

Washington, DC In a new report released today, Robert F. Kennedy, Jr. and his team outlined various criminal acts on the part of employees and consultants for the Centers for Disease Control and Prevention (CDC) whose questionable ethics and scientific fraud have resulted in untrustworthy vaccine safety science.

Among other information, Kennedy has found additional evidence of criminal activity by the CDC consultant, Poul Thorsen, the author and principal coordinator of multiple CDC studies exonerating the mercury-based preservative thimerosal in the development of autism.

The new evidence, recently uncovered by the World Mercury Project, shows that Thorsen and his collaborators did not obtain permission from an Institutional Review Board (IRB) to conduct their research, which was published in the New England Journal of Medicine in 2002 and Pediatrics in 2003.

...

21:59

All Conventional Spices Sold in the U.S. are Fumigated with Hazardous Chemicals Banned in Europe "IndyWatch Feed Health"

This article is shared with permission from our friends at Naturally Savvy. Last year I was invited to an editors summit in New Mexico hosted by Heel Inc. While out for dinner one night, I was sitting next to two people I had just met hours earlier, Suzy and Sam Cohen (Suzy is Americas...

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The post All Conventional Spices Sold in the U.S. are Fumigated with Hazardous Chemicals Banned in Europe appeared first on Healthy Holistic Living.

21:58

Bill Gates Funding MIT Development of Micro Implants to Automatically Give Babies Vaccines "IndyWatch Feed Health"

By Jay Syrmopoulos

A new discovery could revolutionize the way childhood vaccines are administered, as engineers at MIT have invented a way for multiple doses of a vaccine or drug to be given over an extended period of time with only one injection.

The process involves the invention of a new 3-D fabrication method that can generate a novel type of drug-carrying particle that could allow multiple doses of a drug or vaccine to be delivered over an extended period of time, according to MIT News.

This novel fabrication technique, called SEAL (Stamped Assembly of Polymer Layers), creates three-dimensional microparticles that resemble tiny coffee cups that can be filled with vaccines or drugs, which are sealed with a lid. The cups, made of a FDA-approved biocompatible polymer, can be designed to degrade at specific times, spilling out the contents.

We are very excited about this work because, for the first time, we can create a library of tiny, encased vaccine particles, each programmed to release at a precise, predictable time, so that people could potentially receive a single injection that, in effect, would have multiple boosters already built into it. This could have a significant impact on patients everywhere, especially in the developing world where patient compliance is particularly poor, Robert Langer, a noted chemical and biological at the David H. Koch Institute at MIT, said in a statement.

The SEAL technique could provide a new platform that can create nearly any tiny, fillable object with nearly any material, which could provide unprecedented opportunities in manufacturing in medicine and other areas, Langer added.

...

21:57

Robert F. Kennedy, Jr. Exposes New Evidence of CDC Corruption Regarding Vaccines and Autism "IndyWatch Feed Health"

CDC Fraud Corruption

Many of the CDC claims regarding a connection between vaccines and autism is based on fraudulent research.

Robert F. Kennedy, Jr. and World Mercury Project Issue Report Regarding New Evidence of Ongoing Corruption and Scientific Misconduct at CDC

Kennedy hopes new evidence and a fresh look at criminal misconduct will result in law enforcement action, rigorous and transparent vaccine safety science, and safer vaccines.

by World Mercury Project

FOR IMMEDIATE RELEASE, September 18, 2017
Contact: Lyn Redwood, 202-810-1826,

Washington, DC In a new report released today, Robert F. Kennedy, Jr. and his team outlined various criminal acts on the part of employees and consultants for the Centers for Disease Control and Prevention (CDC) whose questionable ethics and scientific fraud have resulted in untrustworthy vaccine safety science.

Among other information, Kennedy has found additional evidence of criminal activity by the CDC consultant, Poul Thorsen, the author and principal coordinator of multiple CDC studies exonerating the mercury-based preservative thimerosal in the development of autism.

The new evidence, recently uncovered by the World Mercury Project, shows that Thorsen and his collaborators did not obtain permission from an Institutional Review Board (IRB) to conduct their research, which was published in the New England Journal of Medicine in 2002 and Pediatrics in 2003.

...

21:56

The Most Common Genetically Modified Foods: AreYou Still Eating Them? "IndyWatch Feed Health"

This article is shared with permission from our friends at Naturally Savvy. The publicity and interest in going green has increased awareness to serious environmental issues surrounding global warming. However, genetically modified organisms (GMOs)also called genetically modified foods or GM foodsare another significant environmental issue that has disappeared in the shadows lately....

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The post The Most Common Genetically Modified Foods: AreYou Still Eating Them? appeared first on Healthy Holistic Living.

21:50

Can Essential Oils Treat an Ear Infection? "IndyWatch Feed Health"

This article is shared with permission from our friends at New Health Advisor. Ear infection is common in both adults and children. The middle ear infection, also called Otitis media (OM), is probably the most common among all types of ear infections. It causes an obstruction in the Eustachian tubes, which...

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21:40

Trophy Hunter Kills Cecil the Lions Son Outside National Park "IndyWatch Feed Health"

Like father, like son is a commonly used phrase of endearment within families. But, this phrase is one that no one ever wanted to hear in relation to the beloved father-son team of lions, Cecil and Xanda, who were killed by trophy hunters within two years of each other. The...

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The post Trophy Hunter Kills Cecil the Lions Son Outside National Park appeared first on Healthy Holistic Living.

21:38

The Alarming Facts About Sanitary Napkins You Should Know Before Using One Again "IndyWatch Feed Health"

Lets face it, ladies: Its not easy being a woman, and getting your period doesnt make it any better. Periods are never convenient and can make regular events such as getting stuck in traffic on your morning commute or sneezing a much bigger deal. Hundreds of years ago, women were...

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The post The Alarming Facts About Sanitary Napkins You Should Know Before Using One Again appeared first on Healthy Holistic Living.

20:49

Phytochemical content and pharma-nutrition study on Eleutherococcus senticosus fruits intractum. "IndyWatch Feed Health"

PMID:  Oxid Med Cell Longev. 2016 ;2016:9270691. Epub 2016 Oct 24. PMID: 27843534 Abstract Title:  Phytochemical Content and Pharma-Nutrition Study on Eleutherococcus senticosus Fruits Intractum. Abstract:  In the past two decades public interest in herbal products has increased significantly in Europe, especially in the plant-based products from non-European traditions. Eleutherococcus senticosus has been used for the treatment of inflammatory diseases, anemia, and rheumatoid arthritis. The Eleutherococcus senticosus fruits intractum was examined for the content of phenolic acids (LC-ESI-MS/MS), minerals (AAS), TPC, and TFC (spectrophotometric assay). The antioxidant activity was determined using free radical scavenging assay and TLC-DB-DPPH() dot-blot test. An anti-Hyal activity was evaluated by the spectrophotometric assay method. Cytotoxicity towards HL-60, HL-60/MX1, HL-60/MX2, CEM/C1, and CCRF/CEM leukemic cell lines was done using trypan blue test. Among eight phenolic acids, trans-caffeic acid was found in the largest amount (41.2mg/gDE). The intractum presented a high amount of macroelements (Ca, Mg, K; 1750, 1300, and 21000mg/kg) and microelements (Fe, Mn; 32.7, 54.3mg/kg), respectively. The content of TPC and TFC was 130 and 92mg/g DE, respectively. The intractum showed anti-Hyal activity (2.16-60%) andan antioxidant capacity (EC50; 52g/mL). The intractum most strongly inhibited the growth of HL-60, HL-60/MX1, and CCRF/CEM. A better understanding of the intractum health benefits is important in order to increase its utility and enrich dietary sources of health promoting compounds.

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20:35

Dorit Rubinstein Reiss an index of contributions to this website "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Dorit Rubinstein Reiss  Professor of Law at the University of California Hastings College of the Law (San Francisco, CA) is a frequent contributor to this and many other blogs, providing in-depth, and intellectually stimulating, articles about vaccines (generally, but sometimes moving to other areas of medicine), social policy and the law. Her articles usually unwind the complexities

Skeptical Raptor

20:30

Natural News is wrong about mandatory vaccinations Part 2 "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

Natural News has had a long history of vaccine denial, which always garners laughter from the scientific skeptic crowd. Occasionally, however, Natural News takes its anti-science beliefs to a whole new level, one that requires a double-pronged rebuttal and refutation. Recently, Natural News published an article that criticizes mandatory vaccinations of healthcare workers both from the scientific

Skeptical Raptor

20:19

Fundamental And Constitutional Rights Negated In The Realm of Totalitarian Corporatocracy "IndyWatch Feed Health"

By Catherine J. Frompovich

Why are U.S. citizens being subjected to inhuman violations of their fundamental and Constitutional rights by vested corporate interests, and no one in Congress, or in the practice of law or the judicial system, is doing anything to correct and to restore basic unalienable human fundamental rights?

Two specific areas of modern commerce present overwhelming examples of gross human rights violations:

  1. The pharmaceutical industry with its consensus vaccine science, which inaccurately promotes and provides neurotoxic vaccines as safe and effective that mandatorily must be inoculated into infants within 24 hours of birth and at 2, 4 and 6 months of age when their immune systems and blood brain barriers are not fully developed, thereby predisposing unknown adverse health risks for which numerous innocent children will be sacrificed for the greater good, i.e., community immunity, with ensuing lifelong harmsor possibly even deathas evidenced by the CDCs VAERS reporting system and HRSA Vaccine VICP Claims Adjudications [1]; and
  2. The microwave industry and its acolyte subsidiary-like industries, e.g., public utilities, which utilize microwaves to provide electric, natural gas and water utilities metering services despite the plethora of scientific documentation regarding EMF/RF/ELF non-thermal radiation waves impairing and damaging DNA, cellular mitochondria and central nervous systems thereby subjecting customers/consume...

20:12

A. senticosus has potential to be developed as an effective anticancer treatment. "IndyWatch Feed Health"

PMID:  Am J Chin Med. 2016 ;44(8):1543-1558. Epub 2016 Nov 16. PMID: 27852123 Abstract Title:  Acanthopanax senticosus: Photochemistry and Anticancer Potential. Abstract:  Acanthopanax senticosus (previously classified as Eleutherococcus senticosus), commonly known as Ciwujia or Siberian Ginseng, is a traditional Chinese medicine (TCM), widely used for its high medicinal value, such as antifatigue, anti-inflammation, antistress, anti-ulcer and cardiovascular functions, in China, Korea, Japan and Russia. In the past decades, researchers worldwide have conducted systematic investigations on this herb, from chemistry to pharmacology, and a large number of chemical components have been characterized for their significant pharmacological effects. However, reports about the anticancer effects of this plant had been rare until recently, when considerable pharmacological experiments both in vitro and in vivo were conducted to study the anticancer effects of this herb. A. senticosus has been found to have inhibitory effects on malignant tumors, such as those in the lung and liver, suggesting that A. senticosus has potential to be developed as an effective anticancer drug. This paper reviews recent findings on the pharmacological properties of A. senticosus, with a focus on its anticancer effects.

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20:00

Natural News is wrong about mandatory vaccinations Part 1 "IndyWatch Feed Health"

The Skeptical Raptor, stalking pseudoscience in the internet jungle.

For the typical American skeptic, there is nothing surprising by a headline that says that Natural News get its it all wrong. Most skeptics might wonder when theyve ever gotten it right. Just to be thorough, Natural News is a website thats focused on anti-science delusions and pushing junk medicine, while marketing a whole boatload

Skeptical Raptor

19:54

These results suggest that syringin protects against lipopolysaccharide induced acute lung injury. "IndyWatch Feed Health"

PMID:  J Surg Res. 2017 Mar ;209:252-257. Epub 2016 Nov 5. PMID: 28032567 Abstract Title:  Protective effects of syringin against lipopolysaccharide-induced acute lung injury in mice. Abstract:  BACKGROUND: Syringin, a major active substance isolated from Eleutherococcus senticosus, has been found to have anti-inflammatory effect. The aim of this study was to investigate the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice.METHODS: We established an LPS-induced ALI model in mice. We also detected the lung wet-to-dry ratio, myeloperoxidase activity, and inflammatory cytokines tumor necrosis factor alpha, interleukin (IL)-1, and IL-6 to estimate the index of lung injury in mice. Furthermore, the expression of nuclear factor-erythroid 2-related factor-2 (Nrf2), heme oxygenase-1, and nuclear factor B (NF-B) was detected by Western blot analysis.RESULTS: The results showed that the increases in lung wet-to-dry ratio, myeloperoxidase activity, malondialdehyde content, and levels of tumor necrosis factor alpha, IL-1, and IL-6 induced by LPS were significantly inhibited by treatment of syringin. The phosphorylation of IB- and p65 NF-B caused by LPS was inhibited by syringin. Furthermore, syringin was found to upregulate the expression of Nrf2 and heme oxygenase 1.CONCLUSIONS: In conclusion, the results suggest that syringin protects against LPS-induced ALI by activating Nrf2 and inhibiting NF-B signaling pathway.

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19:46

Chemical constituents of Eleutherococcus sessiliflorus extract have sedative and hypnotic effects. "IndyWatch Feed Health"

PMID:  Nat Prod Res. 2017 Sep ;31(17):1995-2000. Epub 2017 Jan 4. PMID: 28049349 Abstract Title:  Chemical constituents of Eleutherococcus sessiliflorus extract and its sedative-hypnotic effect. Abstract:  The present study was designed to investigate the chemical constituents and bioactivities of the roots of Eleutherococcus sessiliflorus (E. sessiliflorus). The compounds were isolated through various chromatography techniques and elucidated by mass spectrometric (MS), 1D- and 2D-NMR analyses. The sedative-hypnotic effect of E. sessiliflorus ethanol extract and its fractions (acetic ether, n-butanol and water fraction) were also investigated. In the chemical constituent study, one new compound, 3-ethyl-5-hydroxy-3-(hydroxymethyl) pentyl-3-(3,4-dihydroxyphenyl) acrylate and fourteen known compounds were isolated and identified. The chromatographic fingerprint of E. sessiliflorus was established by UPLC-PDA-MS/MS analysis. In bioactivity study, it was found that the water fraction of E. sessiliflorus extract could prolong pentobarbital-induced sleeping time more than that of the other fractions of E. sessiliflorus extract in mice, which provided a basis for future study on sedative-hypnotic effect of the chemical constituents in E. sessiliflorus.

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19:33

Ginseng extracts could be used to improve some of the symptoms related to alcohol hangover. "IndyWatch Feed Health"

PMID:  Hum Psychopharmacol. 2017 Sep ;32(5). Epub 2017 May 31. PMID: 28568743 Abstract Title:  Interventions for treatment and/or prevention of alcohol hangover: Systematic review. Abstract:  OBJECTIVE: To evaluate new research conducted over the past few years (2009-2016) assessing the effectiveness of potentially curative and/or preventive methods of alcohol hangover.METHODS: Data were retrieved by a 4-stage systematic search process. A search of the online Pubmed and Scopus databases were performed, using a combination of keywords:"Alcohol,""Ethanol,"and"C2 H5 OH,"in combination with the terms"Hangover,""Treatment,"and"Prevention."The search comprised studies listed between January 1, 2009 and June 30, 2016. Findings were synthesized using a systematic approach. Quantitative analysis was not done because of the heterogeneity of the included studies.RESULTS: Six controlled human studies were identified (placebo controlled-3, controlled studies with a comparator intervention-3). Of the interventions, the use of polysaccharide rich extract of Acanthopanax senticosus, red ginseng antihangover drink, Korean pear juice, KSS formula, and the After-Effect were associated with a significant improvement of hangover symptoms (p 

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19:26

These results show that Korean red ginseng inhibition of hypoxia-induced COX-2 expression and cell invasion is dependent on PPAR activation. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Jul ;41(3):240-246. Epub 2016 Apr 13. PMID: 28701863 Abstract Title:  Inhibition of hypoxia-induced cyclooxygenase-2 by Korean Red Ginseng is dependent on peroxisome proliferator-activated receptor gamma. Abstract:  BACKGROUND: Korean Red Ginseng (KRG) is a traditional herbal medicine made by steaming and drying fresh ginseng. It strengthens the endocrine and immune systems to ameliorate various inflammatory responses. The cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway has important implications for inflammation responses and tumorigenesis. Peroxisome proliferator-activated receptor gamma (PPAR) is a transcription factor that regulates not only adipogenesis and lipid homeostasis, but also angiogenesis and inflammatory responses.METHODS: The effects of the KRG on inhibition of hypoxia-induced COX-2 via PPAR in A549 cells were determined by luciferase assay, Western blot, and/or quantitative reverse transcription-polymerase chain reaction (qRT-PCR). The antimigration and invasive effects of KRG were evaluated on A549 cells using migration and matrigel invasion assays.RESULTS AND CONCLUSION: We previously reported that hypoxia-induced COX-2 protein and mRNA levels were suppressed by KRG. This study examines the possibility of PPAR as a cellular target of KRG for the suppression of hypoxia-induced COX-2. PPAR protein levels and PPAR-responsive element (PPRE)-driven reporter activities were increased by KRG. Reduction of hypoxia-induced COX-2 by KRG was abolished by the PPAR inhibitor GW9662. In addition, the inhibition of PPAR abolished the effect of KRG on hypoxia-induced cell migration and invasion.DISCUSSION: Our results show that KRG inhibition of hypoxia-induced COX-2 expression and cell invasion is dependent on PPAR activation, supporting the therapeutic potential for suppression of inflammation under hypoxia. Further studies are required to demonstrate whether KRG activates directly PPAR and to identify the constituents responsible for this activity.

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19:08

Meningococcal Outbreak In Australia Has Many Questioning Government "IndyWatch Feed Health"

Australia is now in the midst of a meningococcal outbreak causing many people to wonder if stiffer vaccination laws are the culprit. Another theory is that the outbreak is a false flag being used to...

The post Meningococcal Outbreak In Australia Has Many Questioning Government appeared first on Vaxxter.

18:45

Illinois School Keeps Unvaccinated Home "IndyWatch Feed Health"

A Champaign, Illinois school, Unit 4 (Kenwood elementary), is claiming that they are winning the vaccine battle. However, it seems many parents remain hold outs on getting vaccines for their kids. The school is crediting...

The post Illinois School Keeps Unvaccinated Home appeared first on Vaxxter.

18:27

These results provide strong evidence to support the development of sun ginseng for antiobesity treatment. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Jul ;41(3):257-267. Epub 2016 May 4. PMID: 28701865 Abstract Title:  Processed Panax ginseng, sun ginseng, inhibits the differentiation and proliferation of 3T3-L1 preadipocytes and fat accumulation in Caenorhabditis elegans. Abstract:  BACKGROUND: Heat-processed ginseng, sun ginseng (SG), has been reported to have improved therapeutic properties compared with raw forms, such as increased antidiabetic, anti-inflammatory, and antihyperglycemic effects. The aim of this study was to investigate the antiobesity effects of SG through the suppression of cell differentiation and proliferation of mouse 3T3-L1 preadipocyte cells and the lipid accumulation in Caenorhabditis elegans.METHODS: To investigate the effect of SG on adipocyte differentiation, levels of stained intracellular lipid droplets were quantified by measuring the oil red O signal in the lipid extracts of cells on differentiation Day 7. To study the effect of SG on fat accumulation in C. elegans, L4 stage worms were cultured on an Escherichia coli OP50 diet supplemented with 10 g/mL of SG, followed by Nile red staining. To determine the effect of SG on gene expression of lipid and glucose metabolism-regulation molecules, messenger RNA (mRNA) levels of genes were analyzed by real-time reverse transcription-polymerase chain reaction analysis. In addition, the phosphorylation of Akt was examined by Western blotting.RESULTS: SG suppressed the differentiation of 3T3-L1 cells stimulated by a mixture of 3-isobutyl-1-methylxanthine, dexamethasone, and insulin (MDI), and inhibited the proliferation of adipocytes during differentiation. Treatment of C. elegans with SG showed reductions in lipid accumulation by Nile red staining, thus directly demonstrating an antiobesity effect for SG. Furthermore, SG treatment downregulated mRNA and protein expression levels of peroxisome proliferator-activated receptor subtype (PPAR) and CCAAT/enhancer-binding protein-alpha (C/EBP) and decreased the mRNA level of sterol regulatory element-binding protein 1c in MDI-treated adipocytes in a dose-dependent manner. In differentiated 3T3-L1 cells, mRNA expression levels of lipid metabolism-regulating factors, such as amplifying mouse fatty acid-bindingprotein 2, leptin, lipoprotein lipase, fatty acid transporter protein 1, fatty acid synthase, and 3-hydroxy-3-methylglutaryl coenzyme A reductase, were increased, whereas that of the lipolytic enzyme carnitine palmitoyltransferase-1 was decreased. Our data demonstrate that SG inversely regulated theexpression of these genes in differentiated adipocytes. SG induced increases in the mRNA expression of glycolytic enzymes such as glucokinase and pyruvate kinase, and a decrease in the mRNA level of the glycogenic enzyme phosphoenol pyruvate carboxylase. In addition, mRNA levels of the g...

18:18

Korean red ginseng has a protective effect against FK506-induced damage in LLC-PK1 cells. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Jul ;41(3):284-289. Epub 2016 May 24. PMID: 28701868 Abstract Title:  Protective effect of Korean Red Ginseng against FK506-induced damage in LLC-PK1 cells. Abstract:  BACKGROUND: Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated.METHODS: LLC-PK1 cells were exposed to FK506 with KRG and cell viability was measured. Western blotting and RT-PCR analyses evaluated protein expression of MAPKs, caspase-3, and KIM-1. TLR-4 gene expression was assessed. Caspase-3 activities were also determined. The number of apoptotic cells was measured using an image-based cytometric assay.RESULTS: The reduction in LLC-PK1 cell viability by 60M FK506 was recovered by KRG cotreatment in a dose-dependent manner. The phosphorylation of p38, p44/42 MAPKs (ERK), KIM-1, cleaved caspase-3, and TLR-4 mRNA expression was increased markedly in LLC-PK1 cells treated with 60M FK506. However, with the exception of p-ERK, elevated levels of p-p38,KIM-1, cleaved caspase-3, and TLR-4 mRNA expression were significantly decreased after cotreatment with KRG. Activity level of caspase-3 was also attenuated by KRG cotreatment. Moreover, image-based cytometric assay showed that apoptotic cell death was increased by 60M FK506 treatment, whereas itwas decreased after cotreatment with KRG.CONCLUSION: Taken together, these results suggest that the molecular mechanism of KRG in the FK506-induced nephrotoxicity may lead to the development of an adjuvant for the inhibition of adverse effect FK506 in the kidney.

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18:10

Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. "IndyWatch Feed Health"

PMID:  Lab Invest. 2017 Jul 31. Epub 2017 Jul 31. PMID: 28759009 Abstract Title:  Ginseng extract reduces tacrolimus-induced oxidative stress by modulating autophagy in pancreatic beta cells. Abstract:  We previously reported that long-term treatment with a calcineurin inhibitor impairs autophagy process in pancreatic beta cells. This study investigated the effect of Korean red ginseng extract (KRGE) on autophagy modulated by oxidative stress. In mice with tacrolimus (Tac)-induced diabetes mellitus, KRGE alleviated islet dysfunction and decreased oxidative stress and autophagic vacuoles. In vitro, KRGE decreased autophagosome formation and attenuated lysosomal degradation, accompanied by improved beta cell viability and insulin secretion. Addition of 3-methyladenine (3-MA), an inhibitor of autophagosomes, to KRGE further improved cell viability and insulin secretion, and bafilomycin A (BA), an inhibitor of lysosomal function, reduced the effects of KRGE. At the subcellular level, Tac caused mitochondrial dysfunction (impaired mitochondrial oxygen consumption, ATP production, and increased reactive oxygen species production). But KRGE improved these parameters. The effect of KRGE on mitochondrial function enhanced by 3-MA but decreased by BA, suggesting a causal relationship between KRGE effect and autophagy modulation in Tac-induced mitochondrial dysfunction. These findings indicate that KRGE modulates autophagy favorably by reducing Tac-induced oxidative stress, and this effect is closely associated with improvement of mitochondrial function.Laboratory Investigation advance online publication, 31 July 2017; doi:10.1038/labinvest.2017.75.

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17:58

Proactive systemic administration of Korean red ginseng may effectively reduce early allergic sensitization and suppress the Th2 response. "IndyWatch Feed Health"

PMID:  J Korean Med Sci. 2017 Apr ;32(4):679-687. PMID: 28244297 Abstract Title:  Therapeutic Effects of Korean Red Ginseng Extract in a Murine Model of Atopic Dermatitis: Anti-pruritic and Anti-inflammatory Mechanism. Abstract:  Korean red ginseng (KRG) and ginsenosides exhibit diverse biological effects, including anti-inflammatory and anti-allergic. We aimed to investigate the therapeutic effect of KRG in a murine model of atopic dermatitis (AD) is mediated whether by diminishing the pruritus or by suppressing the inflammation. Thirty NC/Nga mice were randomly divided to 5 groups. AD-like skin lesions were induced by percutaneous challenge with 2,4,6-trinitro-1-chrolobenzene (TNCB) on the ears and backs of NC/Nga mice. KRG extract, evening primrose oil, cyclosporine, and phosphate-buffered saline were administered orally by a gastric tube. Each study group was also divided into scratching-permitted and scratching-restricted subgroups to evaluate the impact of scratching behavior on AD. The effects of KRG and the other agents were assessed by measuring the clinical severity score, ear thickness, extent of transepidermal water loss (TEWL), number of scratching movements, total systemic immunoglobulin E (IgE) and interleukin (IL)-31 levels, histologic changes of cutaneous lesions, and mRNA expression levels of tumor necrosis factor (TNF)-, interferon (IFN)-, thymic stromal lymphopoietin (TSLP), and IL-31. KRG exerts therapeutic effects against AD by inhibiting the T helper 2 (Th2) mediated inflammation as well as by diminishing the itching sensation. Moreover, restricting scratching behavior suppresses the vicious cycle of itching and scratching, thus reducing clinical and systemic inflammation in our murine model of AD.

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17:29

Post-publication peer review in action: Science flags paper just days after publication "IndyWatch Feed Health"

Science has issued an expression of concern for a widely covered materials science paper published on Friday, citing issues with the supplementary data. The paper  which caught the attention of multiple news outlets added properties to cotton fibers in vitro, potentially enabling researchers to manufacture fabric that can fluoresce or carry magnetic properties. The []

The post Post-publication peer review in action: Science flags paper just days after publication appeared first on Retraction Watch.

16:38

Invisible Plastic Nanoparticles Now Being Found In Drinking Water "IndyWatch Feed Health"

microplastics drinking water

By Heather CallaghanEditor

OrbMedia asks: If microscopic plastic is in oceans, lakes, and rivers, is it in drinking water as well?

In the first public scientific study of its kind, we found previously unknown plastic contamination in the tap water of cities around the world, they wrote recently in a special edition.

They claim everyone in the world is consuming plastic with each drink of water. As weve written before, plastics mimic hormones in the body and these can cause obesity and reproductive issues.

Microscopic plastic fibers are flowing out of taps from New York to New Delhi, according to exclusive research by Orb and a researcher at the University of Minnesota School of Public Health. From the halls of the U.S. Capitol to the shores of Lake Victoria in Uganda, women, children, men, and babies are consuming plastic with every glass of water.

More than 80 percent of the samples we collected on five continents tested positive for the presence of plastic fibers.

Microplastics tiny plastic fibers and fragments arent just choking the ocean; they have infested the worlds drinking water.

If that werent bad enough, they write...

15:49

(2)  Big Pharmas Influence in Congress "IndyWatch Feed Health"

Bernie and Donald AGREE On The Big Pharma Issue So why cant we solve this problem, like yesterday? Opinion by Deplorable Consumer Advocate Tim Bolen Lately, there has been speculation that there might have been influence by Big Pharma to BLOCK changes to the Health Care System, during the Repeal and Replace ObamaCare action. Of Continue reading (2)  Big Pharmas Influence in Congress  

The post (2)  Big Pharmas Influence in Congress   appeared first on BolenReport.

15:16

Woman Cured Terminal Brain Tumor With Cannabis Oil After Chemo Failed "IndyWatch Feed Health"

By Heather CallaghanEditor

Scottish woman, Lynn Cameron, was told at age 48 that she had just 6 to 18 months to live. After a seizure landed her in the hospital in 2013, doctors discovered a brain tumor. She had surgery to remove the deadly brain tumor but doctors told her they couldnt get it all and that she was now in Stage 4, terminal condition. Radiation and chemotherapy did not shrink her tumor so her condition was still labeled incurable.

She began researching alternative therapies and first began an alkalizing diet and removed all processed sugar from her diet. When the radiation and chemo didnt change the tumor, she decided to really break the mold.

She tried cannabis oil after a friend suggested it. CBD oil is allowed to be prescribed in the UK, after its regulatory body, the MHRA found it to have a restoring, correcting or modifying effect when given to humans. See: First Briton Prescribed Cannabis Now Free Of Deadly Epilepsy And Seizures

After trying cannabis oil leaving it under the tongue for better absorption Lynn began getting MRI check-up scans. She was skeptical that it would work, but each successive scan showed the tumor shrinking. The sixth scan revealed that she was cancer free!

She told the Daily Record, I found it hard to believe that it would cure brain cancer so ad...

15:15

More Doctors and Scientists Now Agree: Depression Is a Physical Illness "IndyWatch Feed Health"

By Alex Pietrowski

For those looking for a way out of depression, recent research offers a totally different approach than is what is being offered by most doctors and psychiatrists. It centers around the findings in a host of new research which suggests that many cases of depression may be physical in nature, rather than rooted in a chemical imbalance or psychological disturbance.

Some 13 million Americans suffer from some form of depression, and some 350 million people worldwide are thought to have it. Typically, medical treatment centers around the restoration of certain chemicals in the brain which are believed to be required for happiness, even though it has already been acknowledged that this link has not been clearly identified.

To understand what imbalance is, we must know what balance looks like, and neuroscience, to date, has not characterized the optimal brain state, nor how to even assess for it.

A New England Journal of Medicine review on Major Depression, stated:

numerous studies of norepinephrine and serotonin metabolites in plasma, urine, and cerebrospinal fluid as well as postmortem studies of the brains of patients with depression, have yet to identify the purported...

14:00

Stem cell scientist appealing dismissal loses another paper "IndyWatch Feed Health"

A once-prominent stem cell biologist, who recently lost both her job and a sizable grant, has lost her fifth paper. Recently, Molecular and Cellular Biology retracted a 2003 paper by Susana Gonzalez. Last February, the National Center for Cardiovascular Research (CNIC) in Spain dismissed her from her position over allegations of misconduct. The reason: suspicions []

The post Stem cell scientist appealing dismissal loses another paper appeared first on Retraction Watch.

12:03

FDA Approves Drug for the Annoyingly Cheerful (The Onion) "IndyWatch Feed Health"

From The Onion: Made by Pfizer, Despondex is the first drug designed to treat the symptoms of excessive perkiness.

Video 

12:03

Triple D for Autism Speaks: Double Digit Drop as President's Salary Exceeds Grants to Families "IndyWatch Feed Health"

NOTE: Thank you to our Nancy Hokkanen for the heads up on AS's "income down." Couldn't have happened to a "nicer" org. We've been critical of Autism Speaks since our inception watching them let down the c0mmunity time and again...

12:02

Why do People Self-Harm? You Asked Heres the Answer "IndyWatch Feed Health"

In this piece for The Guardian, Jay Watts explores the social and societal factors that often lead to self-harm and explains how psychiatric labeling can exacerbate self-harm.

Self-harm is also often the result of a clash between an ideal image and ones self-image. For example, if a teenager feels that they have to do brilliantly at school to get into a top university for Mum and Dad, not achieving that 10th A* can feel like a shattering blow crystallising long-held beliefs that they are not good enough. Early caregiving has a crucial function in ensuring kids develop a good-enough self-image that can withstand the bumps and bruises of life. However, the likelihood that an acceptable sense of self will collapse is also a function of the ideals of society at any given time, hence the current epidemic of self-harm.

A neoliberal culture that pits kids against one another at an ever earlier age, digital culture, and a hypersexualised environment that privileges certain body-ideals all serve to increase the likelihood of a catastrophic gulf between the ideal and actual self-image. Discrimination is also a huge trigger behind the startling rates of self-harm in LGBT communities. Societal hatred of difference gets drip fed into individuals whatever their conscious beliefs, and enacted on their own body.

12:01

Psych Journal Issuing Caution About Torture Paper "IndyWatch Feed Health"

From Retraction Watch: The psychology journal Teaching of Psychology plans to issue an editors note about a controversial paper exploring the APAs involvement in the torture of terror subjects, which was published last June. The editors note cautions readers that the paper solely reflects the opinions of the author and states that the subject of the paper is part of a pending lawsuit.

Article

09:00

Rigvir: Another unproven and dubious cancer therapy to be avoided "IndyWatch Feed Health"

Alternative cancer clinics have always claimed that their therapies "boost the immune system" to fight cancer. Recently, the Hope4Cancer Institute, a quack clinic in Mexico has added a treatment known as Rigvir to its other offerings. But what is Rigvir? It turns out that it's an import from Latvia, a purported oncolytic virus with a mysterious history that targets cancer specifically for which there is a profound paucity of evidence for its efficacy. Rigvir was approved by Latvia in 2004 based on grossly inadequate evidence. The story of Rigvir is the story of an unproven treatment that, because of its origin in a small country, has flown mostly under the radar. Until now, that is.

08:55

Peter Breggin, MD: The Conscience of Psychiatry (part 2) "IndyWatch Feed Health"

This week on the Mad in America podcast, we have part 2 of our interview with Dr Peter Breggin.

Dr Breggin is a Harvard-trained psychiatrist and former Consultant at the National Institute of Mental Health (NIMH). He has been called The Conscience of Psychiatry for his many decades of successful efforts to reform the mental health field.

His work provides the foundation for modern criticism of psychiatric diagnoses and drugs and leads the way in promoting more caring and effective therapies. His research and educational projects have brought about major changes in the FDA-approved Full Prescribing Information or labels for dozens of antipsychotic and antidepressant drugs. He continues to educate the public and professions about the tragic psychiatric drugging of Americas children.

He has authored dozens of scientific articles and more than twenty books, including medical books and the bestsellers Toxic Psychiatry and Talking Back to Prozac. His most recent three books are Guilt, Shame and Anxiety: Understanding and Overcoming Negative Emotions; Medication Madness: the Role of Psychiatric Drugs in Cases of Violence, Suicide and Murder; and Psychiatric Drug Withdrawal: A Guide for Prescribers, Therapists, Patients and their Families.

As a medical-legal expert, Dr Breggin has unprecedented and unique knowledge about how the pharmaceutical industry too often commits fraud in researching and marketing psychiatric drugs. He has testified many times in malpractice, product liability and criminal cases, often in relation to adverse drug effects and more occasionally electroshock and psychosurgery.

Dr Breggin has taught at many universities and has a private practice of psychiatry in Ithaca, New York.

For a career as long and distinguished as Dr Breggins we have decided to devote two episodes to hearing him speak. The first part covered Dr Breggins career, his views on psychiatry and psychiatric drugs and also recent developments in the trial involving Michelle Carter.

Part 2 of the interview focuses more on recent events surrounding the trial and alternatives to psychiatric drugs.

...

08:13

Your Longevity May Be Based On How You Perceive Time "IndyWatch Feed Health"

Time perception is a construction of the brain. How fast we perceive time to be passing -- or "mind time" -- can be manipulated or distorted. Evaluations of time differ based on our state of being at the time of judgment. How you age and how long you live may depend on that perception.

07:00

Eat Your Fiber Soluble and Insoluble "IndyWatch Feed Health"

By Dr. Mercola

What constitutes soluble as opposed to insoluble fiber is something not everyone is clear on, especially in regard to their importance. In discussing fiber, there are two types: soluble and insoluble. Most consider fiber a tool to aid in healthy digestion, but it does so much more. Dietary fiber, the indigestible part of plant material, is considered an essential nutrient because only through eating it is fiber made available to your body, and you need both kinds. Some foods are made up of both soluble and insoluble fiber.

Any portion of a plant-based food that doesn't break down when you eat it or isn't readily absorbed into your body is referred to as indigestible. Fiber is also sometimes called roughage, a term that describes, to a degree, the function of fiber as it moves through your colon and, in the process, helps move along food particles that may tend to adhere to the sides. Food that remains stuck to your colon may cause bloating, pain and constipation, as well as other problems.

Vegetables, certain fruits, seeds and nuts are all important to include in your diet on a regular basis because, besides providing nutrients, they contain the fiber necessary to promote regular bowel movements and keep your colon free of obstruction, while providing countless other health benefits.

Aspects of Soluble Fiber

Soluble fiber is easily dissolved in water and becomes gel-like when it reaches your large intestine so it's more easily broken down by liquids and gastrointestinal fluids and releases certain gases. Some of the benefits of this type of fiber are that:1

  • The thick gel moves into every crevasse in your colon and helps to slow down your digestion. This helps you to feel full longer and is one reason why fiber may help with weight control.
  • It prevents some dietary cholesterol from being broken down and digested, which serves to help optimize cholesterol levels.
  • It slows down the rate at which other nutrients are digested, including carbs, so they're not as likely to raise your blood glucose; it also helps stabilize your glucose levels and even prevent blood sugar spikes.
  • It helps lower your risks of developing heart disease and hypertension.
  • Some foods rich in soluble fiber help feed good bacteria in your gut.

Attributes of Insoluble Fiber and Overall Benefits of Both

Insoluble f...

Multiday Fasting Gaining Popularity as a Powerful Biohack for Health and Longevity "IndyWatch Feed Health"

By Dr. Mercola

One lifestyle factor that appears to be driving not only obesity but also many chronic disease processes is the fact that we avoid ever going without food for very long. Our ancestors didn't have access to food 24/7, and biologically your body simply isn't designed to run optimally when continuously fed. If you eat throughout the day and never skip a meal, your body adapts to burning sugar as its primary fuel, which down-regulates enzymes that utilize and burn stored fat.

If you struggle to lose weight, this may well be a significant part of the problem your body has simply lost the metabolic flexibility to burn fat for fuel. To correct this, you need to reduce net carbs and, ideally, the frequency of your meals. Fasting is one of the oldest dietary interventions in the world, and modern science confirms it can have a profoundly beneficial influence on your health. As noted by Fitness and Power:1

"An increasing number of researchers are saying that the intermittent fasting method is a sure-fire way for people to shred the excess fat. A study published in 2015 in the European Journal of Clinical Nutrition found that intermittent fasting gives a safe rate weight loss of 0.5 to 1.7 lbs/week, along with decreasing the overall body fat percentage."

Research has also confirmed that many important biological repair and rejuvenation processes take place in the absence of food, and this is another reason why all-day grazing triggers disease. In a nutshell, your body was designed to a) run on healthy fat as its primary fuel, and b) cycle through periods of feast and famine. Today, most people do the opposite.

Intermittent Fasting Versus Longer Fasts

Intermittent fasting is an umbrella term that covers many different meal timing schedules. As a general rule, it involves cutting calories in whole or in part, either a couple of days a week, every other day or even daily.2 The key is the cycling of feasting/feeding and famine/fasting. By mimicking the eating habits of our ancestors, who did not have access to food around the clock, you restore your body to a more natural state that allows a whole host of biochemical benefits to occur...

Top Foods to Help Lower Blood Pressure "IndyWatch Feed Health"

By Dr. Mercola

You've heard it before what you eat has a direct impact on your health, and the quality of your health naturally affects how you feel. Your blood pressure readings aren't just one isolated aspect of health but are intrinsically tied to many other functions of your body. That said, there are foods to stay away from and foods you should begin eating more of to optimize how well your blood is pumped through your body.

Vegetables are on the short list of foods you should be eating more of to naturally lower your blood pressure. But certain fruits, in moderation, including nuts and seeds, also have a place in lowering your risk for not just high blood pressure, but many related illnesses such as kidney disease, heart disease, stroke and several forms of dementia.

DASH, Mediterranean and PAMM Diets: Do They Work to Combat Hypertension?

The DASH diet, or Dietary Approaches to Stop Hypertension,1 consists largely of fresh vegetables, fruits, lean protein, whole grains, low-fat dairy and very low sodium content. It's often believed that it's the low-sodium aspect of the diet that's so important, but this diet may work for some primarily because it's low in sugar/fructose. The same holds true for reducing your intake of processed foods, which you'll do if you follow the diet, as processed foods are top sources of both heavily processed salt and sugar/fructose.

There are, however, healthier eating plans than the DASH diet, particularly since whole grains and low-fat dairy are not foods I recommend eating. As for the Mediterranean Diet, this "diet" has been around for centuries.

Because the Mediterranean region is known for their rich olives and olive oil, fresh vegetables, fruits, seafood and, infrequently, red meat, people living there are known to be some of the healthiest, longest-living people in the world. Most of the diet's health benefits are likely due to it being low in sugars, moderate in protein and high in fresh fruits and vegetables, along with healthy fats.

Dr. Stephen Sinatra's PAMM, or Pan-Asian Modified Mediterranean, diet is another slant on the Mediterranean diet, which highlights the crucial nature of eating a "high-fiber, healthy-fat, Mediterranean-type, heart-healthy diet," emphasizing healthy fats and ve...

05:13

Korean red ginseng may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as atopic dermatitis. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Apr ;41(2):134-143. Epub 2016 Feb 19. PMID: 28413317 Abstract Title:  Korean Red Ginseng improves atopic dermatitis-like skin lesions by suppressing expression of proinflammatory cytokines and chemokines in vivo and in vitro. Abstract:  BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-B) pathway in allergic inflammation.METHODS: Compound 48/80-induced anaphylactic shock and 1-fluoro-2,4-dinitrobenzene (DNFB)-induced AD-like skin lesion mice models were used to investigate the antiallergic effects of RGE. Human keratinocytes (HaCaT cells) and human mast cells (HMC-1) were also used to clarify the effects of RGE on the expression of proinflammatory cytokines and chemokines.RESULTS: Anaphylactic shock and DNFB-induced AD-like skin lesions were attenuated by RGE administration through reduction of serum immunoglobulin E (IgE) and interleukin (IL)-6 levels in mouse models. RGE also reduced the production of proinflammatory cytokines including IL-1, IL-6, and IL-8, and expression of chemokines such as IL-8, thymus and activation-regulated chemokine (TARC), and macrophage-derived chemokine (MDC) in HaCaT cells. Additionally, RGE decreased the release of tumor necrosis factor- (TNF-), IL-1, IL-6, and IL-8 as well as expressions of chemokines including macrophage inflammatory protein (MIP)-1, MIP-1, regulated on activation, normal T cell expressed and secreted (RANTES), monocyte chemoattractant protein (MCP)-1, and IL-8 in HMC-1 cells. Furthermore, our data demonstrated that these inhibitory effects occurred through blockage ofthe MAPK and NF-B pathway.CONCLUSION: RGE may be a useful therapeutic agent for the treatment of allergic inflammatory diseases such as AD-like dermatitis.

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05:05

Korean red ginseng prolongs survival in HIV-1 patients, possibly by slowing the decrease in CD4+ T-cell count. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Apr ;41(2):222-226. Epub 2017 Jan 6. PMID: 28413328 Abstract Title:  Effect of Korean Red Ginseng intake on the survival duration of human immunodeficiency virus type 1 patients. Abstract:  BACKGROUND: Long-term ginseng intake can increase longevity in healthy individuals. Here, we examined if long-term treatment with Panax ginseng Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with human immunodeficiency virus type 1 (HIV-1) infection.METHODS: We retrospectively analyzed 252 HIV-1 patients diagnosed from 1986 to 2013 prior to the initiation of antiretroviral therapy. Overall, 162 patients were treated with KRG (3,947  4,943 g) for 86  63 mo. The effects of KRG on SD were analyzed according to the KRG intake level and the length of the follow-up period.RESULTS: There were significant correlations between the total amount of KRG and SD in the KRG intake group (r = 0.64, p 

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04:56

Ginsenoside Rg3-enriched Korean red ginseng enhances blood pressure stability in spontaneously hypertensive rats. "IndyWatch Feed Health"

PMID:  Integr Med Res. 2016 Sep ;5(3):223-229. Epub 2016 Jun 3. PMID: 28462122 Abstract Title:  Rg3-enriched Korean Red Ginseng enhances blood pressure stability in spontaneously hypertensive rats. Abstract:  BACKGROUND: Korean Red Ginseng (Panax ginseng) has been shown to exert antihypertensive effects. In particular, ginsenoside Rg3 is thought to be a potent modulator of vascular function. The present study was performed to examine the antihypertensive efficacy of Korean Red Ginseng (KRG) extract and Rg3-enriched KRG (REKRG) extract.METHODS: Spontaneously hypertensive rats (SHRs) and Wistar-Kyoto rats (WKYs) were divided into six groups (WKY control, WKY-KRG, WKY-REKRG, SHR control, SHR-KRG, and SHR-REKRG), and systolic blood pressure (SBP) and diastolic blood pressure (DBP) were measured at the carotid artery, followed by injection of 3 mg/kg KRG or 3 mg/kg REKRG.RESULTS: REKRG treatment significantly decreased SBP and DBP 3 hours post-treatment in the SHR group compared with SHR control group. However, SBP and DBP were not significantly different in KRG-treated SHRs compared with control SHRs. REKRG treatment did not significantly alter SBP or DBP 3 hours post-treatment in the WKY group compared with WKY control group. Similarly, there were no differences in SBP or DBP with KRG treatment in the WKY group and WKY control group. Both KRG and REKRG increased endothelial nitric oxide synthase phosphorylation levels in the aorta, and the increases in endothelial nitric oxide synthase phosphorylation levels by REKRGtreatment were higher than those with KRG treatment. Similarly, nitric oxide production in plasma from WKYs and SHRs was also increased by both KRG and REKRG.CONCLUSION: These results suggest that REKRG has a more beneficial effect on blood pressure control than KRG in SHRs.

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04:38

Korean red ginseng extract can enhance the activity of sorafenib and may have a substantial potential in the treatment of renal cell carcinoma. "IndyWatch Feed Health"

PMID:  Phytother Res. 2017 Jul ;31(7):1078-1089. Epub 2017 May 22. PMID: 28544385 Abstract Title:  Korean Red Ginseng Extract Enhances the Anticancer Effects of Sorafenib through Abrogation of CREB and c-Jun Activation in Renal Cell Carcinoma. Abstract:  Although application of sorafenib in the treatment of human renal cell carcinoma (RCC) remains one of the best examples of successful targeted therapy, majority of RCC patients suffer from its side effects as well as develop resistance to this targeted therapy. Thus, there is a need to promote novel alternative therapies for the treatment of RCC. In this study, we investigated whether Korean red ginseng extract (KRGE) could inhibit the proliferation and induce chemosensitization in human renal cancer cells. Also, we used a human phospho-antibody array containing 46 antibodies against signaling molecules to examine a subset of phosphorylation events after KRGE and sorafenib combination treatment. Korean red ginseng extract suppressed the proliferation of two RCC cell lines; activated caspase-3; caused poly(ADP-ribose) polymerase cleavage; abrogated the expression of B-cell lymphoma 2, B-cell lymphoma extra large, survivin, inhibitors of apoptosis proteins-1/2, cyclooxygenase-2, cyclin D1, matrix metallopeptidase-9, and vascular endothelial growth factor; and upregulated pro-apoptotic gene products. Interestingly, KRGE enhanced the cytotoxic and apoptotic effects of sorafenib in RCC cells. The combination treatment of KRGE and sorafenib more clearly suppressed cyclic adenosine monophosphate response element-binding protein and c-Jun phosphorylation and induced phosphorylation of p53 than did the individual treatment regimen. Our results clearly demonstrate that KRGE can enhance the anticancer activity of sorafenib and may have a substantial potential in the treatment of RCC. Copyright 2017 John Wiley&Sons, Ltd.

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04:30

A saponin fraction of Korean red ginseng exhibited in vitro and in vivo antitumor activity in C6 glioma glioma cells. "IndyWatch Feed Health"

PMID:  J Ginseng Res. 2017 Jul ;41(3):386-391. Epub 2017 Jan 5. PMID: 28701882 Abstract Title:  Comparison of anticancer activities of Korean Red Ginseng-derived fractions. Abstract:  BACKGROUND: Korean Red Ginseng (KRG) is an ethnopharmacological plant that is traditionally used to improve the body's immune functions and ameliorate the symptoms of various diseases. However, the antitumorigenic effects of KRG and its underlying molecular and cellular mechanisms are not fully understood in terms of its individual components. In this study, in vitro and in vivo antitumorigenic activities of KRG were explored in water extract (WE), saponin fraction (SF), and nonsaponin fraction (NSF).METHODS: In vitro antitumorigenic activities of WE, SF, and NSF of KRG were investigated in the C6 glioma cell line using cytotoxicity, migration, and proliferation assays. The underlying molecular mechanisms of KRG fractions were determined by examining the signaling cascades of apoptotic cell death by semiquantitative reverse transcriptase polymerase chain reaction and Western blot analysis. The in vivo antitumorigenic activities of WE, SF, and NSF were investigated in a xenograft mouse model.RESULTS: SF induced apoptotic death of C6 glioma cells and suppressed migration and proliferation of C6 glioma cells, whereas WE and NSF neither induced apoptosis nor suppressed migration of C6 glioma cells. SF downregulated the expression of the anti-apoptotic gene B-cell lymphoma-2 (Bcl-2) and upregulated the expression of the pro-apoptotic gene Bcl-2-associated X protein (BAX) in C6 glioma cells but had no effect on the expression of the p53 tumor-suppressor gene. Moreover, SF treatment resulted in activation of caspase-3 as evidenced by increased levels of cleaved caspase-3. Finally, WE, SF, and NSF exhibited in vivo antitumorigenic activities in the xenograft mouse model by suppressing the growth of grafted CT-26 carcinoma cells without decreasing the animal body weight.CONCLUSION: These results suggest that WE, SF, and NSF of KRG are able to suppress tumor growth via different molecular and cellular mechanisms, including induction of apoptosis and activation of immune cells.

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04:19

This review provides positive evidence for the efficacy of ginseng on reducing blood pressure in patients with pre-hypertension and hypertension. "IndyWatch Feed Health"

PMID:  Curr Vasc Pharmacol. 2017 Jul 12. Epub 2017 Jul 12. PMID: 28707603 Abstract Title:  Ginseng for the treatment of hypertension: a systematic review and meta-analysis of double-blind, randomized, placebo-controlled trials. Abstract:  BACKGROUND: Evidence of ginseng for reducing blood pressure (BP) in hypertensive patients is controversial. This systematic review updated the previous reviews and evidence for it.METHODS: Ten databases were searched from their inception through October 2016, without language restriction. Randomized clinical trials (RCTs) were included if any types of ginseng were tested as the sole treatment or as an adjunct to other treatments for pre-hypertension or hypertension. The risk of bias (ROB) was assessed with Cochrane ROB tools by two independent reviewers.RESULTS: We found 528 potentially relevant articles, of which 9 RCTs met our inclusion criteria. Two studies reported positive effects of Korean red ginseng (KRG) on acute reduction of systolic BP (SBP: n=54, mean differences (MD), -6.52; P=0.0002; I2=0%) and diastolic BP DBP: MD, -5.21; P=0.0001; I2=0%), while two other trials failed to do so with north American ginseng (NAG) in both SBP and DBP. Five RCTs assessed the long-term effects of ginseng (KRG or NAG) on SBP and DBP. Two studies showed positive effects of KRG on reducing SBP and DBP compared with placebo (SBP: n = 183, MD, -2.92, P=0.04; I2 = 0%; DBP: MD, -3.19, P=0.008; I2 = 0%).CONCLUSION: This systematic review provides positive evidence for the efficacy of KRG on reducing blood pressure in patients with pre-hypertension and hypertension in acute and long-term. Future RCTs appear to be warranted.

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04:03

Ginseng may be able to prevent obesity, hyperlipidemia, and hepatic steatosis in men with testosterone deficiency. "IndyWatch Feed Health"

PMID:  J Ethnopharmacol. 2017 Aug 24 ;210:80-87. Epub 2017 Aug 24. PMID: 28844680 Abstract Title:  Korean red ginseng (Panax ginseng) inhibits obesity and improves lipid metabolism in high fat diet-fed castrated mice. Abstract:  ETHNOPHARMACOLOGICAL RELEVANCE: Korean red ginseng (Panax ginseng C.A. Meyer, Araliaceae) has been historically used as a traditional drug for the prevention and treatment of most ageing-related diseases, such as obesity, dyslipidemia, diabetes, and cardiovascular disease. Elderly men with testosterone deficiency are strongly associated with many of the aforementioned metabolic diseases. The aim of this study was to determine the effects of ginseng on obesity and lipid metabolism in a mouse model of testosterone deficiency (castrated C57BL/6J mice).MATERIALS AND METHODS: The effects of ginseng extract (GE) on obesity and lipid metabolism in high-fat diet (HFD)-fed castrated C57BL/6J mice were examined using hematoxylin and eosin staining, serum lipid analysis, and quantitative real-time polymerase chain reaction (PCR). The effects of GE, ginsenosides, and testosterone on adipogenesis were measured using Oil Red O staining, XTT assay, and real-time PCR.RESULTS: Compared with HFD mice, mice receiving HFD supplemented with GE (HFD-GE) for 8 weeks showed decreased body weight, adipose tissue mass, and adipocyte size without affecting food intake. Serum levels of triglycerides and total cholesterol were lowered in HFD-GE mice than in HFD mice. GE also markedly reduced HFD-induced hepatic lipid accumulation. Concomitantly, HFD-GE decreased mRNA expression of adipogenesis-related genes (SREBP-1C, PPAR, FAS, SCD1, and ACC1) in visceral adipose tissues compared with HFD alone. Consistent with the in vivo data, GE and major active ginsenosides (Rb1 and Rg1) decreased lipid accumulation and mRNA expression of PPAR, C/EBP, and SCD1 in 3T3-L1 adipocytes compared with control. Similarly, testosterone also decreased lipid accumulation and mRNA levels of PPAR, C/EBP, and SCD1. These inhibitory effects were further increased by co-treatment of GE or ginsenosides with testosterone.CONCLUSIONS: Our results demonstrate that ginseng can inhibit obesity and dyslipidemia in HFD-fed castrated mice, possibly by inhibiting adipogenic gene expression. In addition, our results indicate that ginseng may act like testosterone to inhibit adipogenesis, suggesting that ginseng may be able to prevent obesity, hyperlipidemia, and hepatic steatosis in men with testosterone deficiency.

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03:56

Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer. "IndyWatch Feed Health"

PMID:  Acta Pharmacol Sin. 2017 Aug 24. Epub 2017 Aug 24. PMID: 28836581 Abstract Title:  Ginsenosides synergize with mitomycin C in combating human non-small cell lung cancer by repressing Rad51-mediated DNA repair. Abstract:  The use of ginseng extract as an adjuvant for cancer treatment has been reported in both animal models and clinical applications, but its molecular mechanisms have not been fully elucidated. Mitomycin C (MMC), an anticancer antibiotic used as a first- or second-line regimen in the treatment for non-small cell lung carcinoma (NSCLC), causes serious adverse reactions when used alone. Here, by using both in vitro and in vivo experiments, we provide evidence for an optimal therapy for NSCLC with total ginsenosides extract (TGS), which significantly enhanced the MMC-induced cytotoxicity against NSCLC A549 and PC-9 cells in vitro when used in combination with relatively low concentrations of MMC. A NSCLC xenograft mouse model was used to confirm the in vivo synergistic effects of the combination of TGS with MMC. Further investigation revealed that TGS could significantly reverse MMC-induced S-phase cell cycle arrest and inhibit Rad51-mediated DNA damage repair, which was evidenced by the inhibitory effects of TGS on the levels of phospho-MEK1/2, phospho-ERK1/2 and Rad51 protein and the translocation of Rad51 from the cytoplasm to the nucleus in response to MMC. In summary, our results demonstrate that TGS could effectively enhance the cytotoxicity of MMC against NSCLC cells in vitro and in vivo, thereby revealing a novel adjuvant anticancer mechanism of TGS. Combined treatment with TGS and MMC can significantly lower the required concentration of MMC and can further reduce the risk of side effects, suggesting a better treatment option for NSCLC patients.

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03:49

Antibiotic use induced perturbations in the microbial diversity during post-natal development of animals which altered amyloid pathologies. "IndyWatch Feed Health"

PMID:  Sci Rep. 2017 Sep 5 ;7(1):10411. Epub 2017 Sep 5. PMID: 28874832 Abstract Title:  Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1E9 murine model of Alzheimer's disease. Abstract:  Recent evidence suggests the commensal microbiome regulates host immunity and influences brain function; findings that have ramifications for neurodegenerative diseases. In the context of Alzheimer's disease (AD), we previously reported that perturbations in microbial diversity induced by life-long combinatorial antibiotic (ABX) selection pressure in the APPSWE/PS1E9 mouse model of amyloidosis is commensurate with reductions in amyloid- (A) plaque pathology and plaque-localised gliosis. Considering microbiota-host interactions, specifically during early post-natal development, are critical for immune- and neuro-development we now examine the impact of microbial community perturbations induced by acute ABX exposure exclusively during this period in APPSWE/PS1E9 mice. We show that early post-natal (P) ABX treatment (P14-P21) results in long-term alterations of gut microbial genera (predominantly Lachnospiraceae and S24-7) and reduction in brain Adeposition in aged APPSWE/PS1E9 mice. These mice exhibit elevated levels of blood- and brain-resident Foxp3(+) T-regulatory cells and display an alteration in the inflammatory milieu of the serum and cerebrospinal fluid. Finally, we confirm that plaque-localised microglia and astrocytes are reduced in ABX-exposed mice. These findings suggest that ABX-induced microbial diversity perturbations during post-natal stages of development coincide with altered host immunity mechanisms and amyloidosis in a murine model of AD.

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03:37

Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. "IndyWatch Feed Health"

PMID:  Brain Behav Immun. 2017 Sep 7. Epub 2017 Sep 7. PMID: 28890155 Abstract Title:  Antibiotic-induced microbiota perturbation causes gut endocannabinoidome changes, hippocampal neuroglial reorganization and depression in mice. Abstract:  The microbiota-gut-brain axis (MGBA) regulates the reciprocal interaction between chronic inflammatory bowel and psychiatric disorders. This interaction involves multiple pathways that are highly debated. We examined the behavioural, biochemical and electrophysiological alterations, as well as gut microbiota composition in a model of antibiotic-induced experimental dysbiosis. Inflammation of the small intestine was also assessed. Mice were exposed to a mixture of antimicrobials for 2weeks. Afterwards, they received Lactobacillus casei DG (LCDG) or a vehicle for up to 7days via oral gavage. Perturbation of microbiota was accompanied by a general inflammatory state and alteration of some endocannabinoidome members in the gut. Behavioural changes, including increased immobility in the tail suspension test and reduced social recognition were observed, and were associated with altered BDNF/TrkB signalling, TRPV1 phosphorylation and neuronal firing in the hippocampus. Moreover, morphological rearrangements of non-neuronal cells in brain areas controlling emotional behaviour were detected. Subsequent probiotic administration, compared with vehicle, counteracted most of these gut inflammatory, behavioural, biochemical and functional alterations. Interestingly, levels of Lachnospiraceae were found to significantly correlate with the behavioural changes observed in dysbiotic mice. Our findings clarify some of the biomolecular and functional modifications leading to the development of affective disorders associated with gut microbiota alterations.

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03:28

Inflammation is a key contributor to the genesis and progression of chronic kidney disease. "IndyWatch Feed Health"

PMID:  Contrib Nephrol. 2017 ;191:72-83. Epub 2017 Sep 14. PMID: 28910792 Abstract Title:  Inflammation: A Key Contributor to the Genesis and Progression of Chronic Kidney Disease. Abstract:  It has become apparent that inflammation and inflammatory reactions can evoke renal injury and promote chronic kidney disease (CKD) progression. Under physiological condition, intrarenal vascular distribution is heterogeneous, and medulla is hypoxic. To avoid energy deprivation in the low pO2 regions of the kidney, an array of hormones, autocoids, and vasoactive substances, including medullipin, prostaglandins, endothelins, nitric oxide, angiotensin II, kinins, and adenosine, tonically regulates the microvasculature to ensure a perfect match of the microcirculation (O2 supply) and renal tubules (O2 demand). Inflammation, systemic or intrarenal, not only can abolish the microvascular response to its regulators, but also induces an array of tubular toxins, including reactive oxygen species, leading to tubular injury, nephron dropout, and onset of CKD. Positive acid balance, electrolyte alterations, and intestinal dysbiosis can perpetuate CKD progression. Understanding the role of inflammation in the genesis and progression of CKD will foster the development of strategies to prevent and treat the underlying inflammation and improve CKD outcomes.

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03:23

These findings reveal the adverse effects of HFCS drinking on the reproductive function and lipid metabolism of female rats. "IndyWatch Feed Health"

PMID:  Dev Reprod. 2017 Jun ;21(2):151-156. Epub 2017 Jun 30. PMID: 28785736 Abstract Title:  Effect of High Fructose Corn Syrup (HFCS) Intake on the Female Reproductive Organs and Lipid Accumulation in Adult Rats. Abstract:  High-fructose corn syrup (HFCS) is widely used as sweetener, and its overconsumption is become a major health problem. In the present study, we used adult female rats and applied a 28 days HFCS feeding model to monitor the estrous cycle and changes in tissue weights and histology. Adult female rats were divided into three groups. Animals were fed with ad libitum normal chow and (1) 24 hours tap water (Control group), (2) 12 hours HFCS access during dark period and 12 hours tap water (12H group), and (3) 24 hours HFCS only access (24H group). Total exposure period was 28 days. There is no significant change in body weight between control and HFCS-fed animals. Both absolute and relative weights of ovary in 24H animals were significantly heavier than those in control or 12H animals. The absolute and relative weights of the kidney and liver in 24H groups were significantly heavier than those in control or 12H animals. The estrous cycles of the 24H animals were significantly longer. Histological analyses revealed that 24H ovaries were relatively bigger and possessed more corpus lutea than control ovaries. Uterine sections of 12H and 24H animals showed a well-developed stratum vasculare between inner and outer myometrial layers. The number of endometrial glands were decreased in 12H uteri, and recovered in 24H uteri compared to control. Numbers of convoluted tubule in distal region increased in 12H and 24H kidney samples. Liver specimens of 12H and 24H showed the increased number of fat containing vacuoles. In conclusion, our study demonstrated that HFCS treatment for 28 days could induce (1) changes in length of estrous cycle with extended estrous and diestrous stages, (2) altered ovarian and uterine histology, and (3) liver and renal lipid accumulation. These findings reveal the adverse effects of HFCS drinking on the reproductive function and lipid metabolism of female rats.

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03:15

High fat, high fructose, high cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile ossabaw swine. "IndyWatch Feed Health"

PMID:  Am J Physiol Endocrinol Metab. 2017 Sep 12:ajpendo.00015.2017. Epub 2017 Sep 12. PMID: 28899857 Abstract Title:  High Fat, High Fructose, High Cholesterol Feeding Causes Severe NASH and Cecal Microbiota Dysbiosis in Juvenile Ossabaw Swine. Abstract:  Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal model. Here, we examined the effects of high fat, high fructose corn syrup, high cholesterol Western style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 weeks old) were fed WD (43.0% fat; 17.8% high fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10.5% fat) for 16 wks (n=6 each) or 36 wks (n=4 each). WD-fed pigs developed obesity, dyslipidemia, and systemic insulin resistance compared with CON pigs. In addition, obese WD-fed pigs developed severe NASH, with hepatic steatosis, hepatocyte ballooning, inflammatory cell infiltration, and fibrosis after 16 weeks, with further exacerbation of histological inflammation and fibrosis after 36 wks of WD-feeding. WD-feeding also resulted in robust cecal microbiota changes including increased relative abundances of families and genera in Proteobacteria (P

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03:07

Short forest bathing program is a promising therapeutic method for enhancing heart rate and blood pressure functions. "IndyWatch Feed Health"

PMID:  Int J Environ Res Public Health. 2017 Aug 9 ;14(8). Epub 2017 Aug 9. PMID: 28792445 Abstract Title:  Effects of Short Forest Bathing Program on Autonomic Nervous System Activity and Mood States in Middle-Aged and Elderly Individuals. Abstract:  The present study investigated changes in autonomic nervous system activity and emotions after a short (2 h) forest bathing program in the Xitou Nature Education Area (XNEA), Taiwan. One hundred and twenty-eight (60.0 7.44 years) middle-aged and elderly participants were recruited. Physiological responses, pulse rate, systolic and diastolic blood pressure, heart rate variability (HRV), and psychological indices were measured before and after the program. We observed that pulse rate, systolic and diastolic blood pressure were significantly lower after the program, which indicated physiological benefits from stress recovery. The Profile of Mood States negative mood subscale scores of"tension-anxiety","anger-hostility","fatigue-inertia","depression-dejection", and"confusion-bewilderment"were significantly lower, whereas the positive mood subscale score of"vigor-activity"was higher. Furthermore, participants exhibited significantly lower anxiety levels according to the State-Trait Anxiety Inventory. However, changes in sympathetic and parasympathetic nerve activity were nonsignificant. Our study determined that the short forest bathing program is a promising therapeutic method for enhancing heart rate and blood pressure functions as well as an effective psychological relaxation strategy for middle-aged and elderly individuals.

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03:00

A state-of-the-art review of the health benefits of forest bathing and nature therapy. "IndyWatch Feed Health"

PMID:  Int J Environ Res Public Health. 2017 Jul 28 ;14(8). Epub 2017 Jul 28. PMID: 28788101 Abstract Title:  Shinrin-Yoku (Forest Bathing) and Nature Therapy: A State-of-the-Art Review. Abstract:  BACKGROUND: Current literature supports the comprehensive health benefits of exposure to nature and green environments on human systems. The aim of this state-of-the-art review is to elucidate empirical research conducted on the physiological and psychological effects of Shinrin-Yoku (or Forest Bathing) in transcontinental Japan and China. Furthermore, we aim to encourage healthcare professionals to conduct longitudinal research in Western cultures regarding the clinically therapeutic effects of Shinrin-Yoku and, for healthcare providers/students to consider practicing Shinrin-Yoku to decrease undue stress and potential burnout.METHODS: A thorough review was conducted to identify research published with an initial open date range and then narrowing the collection to include papers published from 2007 to 2017. Electronic databases (PubMed, PubMed Central, CINAHL, PsycINFO and Scopus) and snowball references were used to cull papers that evaluated the use of Shinrin-Yoku for various populations in diverse settings.RESULTS: From the 127 papers initially culled using the Boolean phrases:"Shinrin-yoku"AND/OR"forest bathing"AND/OR"nature therapy", 64 studies met the inclusion criteria and were included in this summary review and then divided into"physiological,""psychological,""sensory metrics"and"frameworks"sub-groups.CONCLUSIONS: Human health benefits associated with the immersion in nature continue to be currently researched. Longitudinal research, conducted worldwide, is needed to produce new evidence of the relationships associated with Shinrin-Yoku and clinical therapeutic effects. Nature therapy as a health-promotion method and potential universal health model is implicated for the reduction of reported modern-day"stress-state"and"technostress.".

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02:54

This systematic review shows a significant effect of Shinrin-yoku on reduction of blood pressure. "IndyWatch Feed Health"

PMID:  BMC Complement Altern Med. 2017 Aug 16 ;17(1):409. Epub 2017 Aug 16. PMID: 28814305 Abstract Title:  Blood pressure-lowering effect of Shinrin-yoku (Forest bathing): a systematic review and meta-analysis. Abstract:  BACKGROUND: Shinrin-yoku (experiencing the forest atmosphere or forest bathing) has received increasing attention from the perspective of preventive medicine in recent years. Some studies have reported that the forest environment decreases blood pressure. However, little is known about the possibility of anti-hypertensive applications of Shinrin-yoku. This study aimed to evaluate preventive or therapeutic effects of the forest environment on blood pressure.METHODS: We systematically reviewed the medical literature and performed a meta-analysis.Four electronic databases were systematically searched for the period before May 2016 with language restriction of English and Japanese. The review considered all published, randomized, controlled trials, cohort studies, and comparative studies that evaluated the effects of the forest environment on changes in systolic blood pressure. A subsequent meta-analysis was performed.RESULTS: Twenty trials involving 732 participants were reviewed. Systolic blood pressure of the forest environment was significantly lower than that of the non-forest environment. Additionally, diastolic blood pressure of the forest environment was significantly lower than that of the non-forest environment.CONCLUSIONS: This systematic review shows a significant effect of Shinrin-yoku on reduction of blood pressure.

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02:28

Lip Twitching: What it Means and How to Treat it Effectively at Home "IndyWatch Feed Health"

Lip twitching can cause annoying tics or slight muscle spasms around your mouth that can be difficult to control. Although most causes of a twitching lip are harmless, the twitching on the left side or right side of your lip, or your upper or lower lip can be a source of embarrassment. Usually, stress, tiredness, a nutrient deficiency, or excessive caffeine intake are to blame for lip twitching. In some cases, a lip that twitches constantly can be a sign of a more serious neurological condition if it is accompanied by other symptoms.

Very often, lip twitching resolves itself on its own within a few minutes or days. Treating occasional or recurring lip twitching is usually a case of addressing the underlying causes. This usually involves relieving stress, getting proper rest, and eating a healthy diet. In some cases, chronic twitching of the lips or an incessant tremors require medical attention to check for other symptoms.

In this article, you will learn what causes lip twitching and what you can do to get rid of the annoying facial tics or tremors around your mouth.

What are Lip Twitches?

Lip twitching is caused by small muscle contractions around the mouth and lips. According to MedlinePlus, most muscle twitches are minor and even normal.1

Dr. Neil Lava on WebMD says that twitches are symptoms of spasm-like movements of certain muscles. Muscle twitches are also called tics or tremors. Dr. Lava says that most twitching of the muscles, including facial muscles, are harmless and temporary. Usually, lifestyle changes help to manage and treat twitching disorders.2

Sometimes, lip twitching may be accompanied by other symptoms. For example, twitching of the left eye or right eye can also accompany lip trembling on one side of your mouth if the condition is caused by a hemifacial spasm.

Causes of Lip Twitching

First, lets look at the common causes of upper or lower lip twitching and what can be to blame for occasional muscle spasms around your lips. You will also find out about the more serious causes of why lips can twitch constantly or develop a facial tic that you cant get rid of.

Stress

Stress can cause facial muscles and nerves to tighten and cause twitching around your upper or lower lips. It is known that stress can cause a wide range of health issues and facial tics and twitching is just one effect.

The journal Movement Disorders found a link between levels of stress and conditions that cause faci...

02:07

When Does Implantation Bleeding Occur and How Does It Look Like? "IndyWatch Feed Health"

Knowing exactly when implantation bleeding occurs is helpful information for women who are trying to get pregnant. Implantation bleeding or spotting can be one of the first visible signs of pregnancy and it usually happens when the fertilized egg implants itself on the wall of the uterus. Bleeding caused by implantation doesnt happen with every woman, however, if it does, implantation spotting may occur around 10 to 14 days after ovulation.

Menstrual bleeding can be easily mistaken for implantation bleeding because the timings can be similar. Also, the spotting on underwear when implantation takes place can look like the start of the menstrual period. Knowing when implantation bleeding starts and what the other signs of pregnancy to look for can help you know if its time to take a pregnancy test.

This article looks at all you need to know about implantation bleeding and how to know when implantation bleeding or spotting happens.

What is Implantation Bleeding?

Implantation bleeding or implantation spotting refers to light vaginal bleeding that occurs when a fertilized egg gets attached to the wall of the uterus or endometrial lining. This causes spotting before your period.

The National Institutes of Health says that about 25% of pregnant women notice light spotting as one of the first signs that conception has happened. However, because implantation bleeding happens around the same time the period is due, it is a reason why many women mistake spotting associated with pregnancy for the start of their period.1

When Does Implantation Bleeding Occur and How Long Does It Last?

When exactly can you expect implantation bleeding to occur if you have become pregnant? There is no exact day when spotting happens due to implantation. However, doctors give a timeframe when you could see the visible signs that fertilization and implantation have occurred.

When the fertilized egg implants into the endometrial lining, some blood vessels are broken down. According to the American Pregnancy Association, this results in slight bleeding that can happen about 10 days after ovulation.2

Regarding the time when to expect implantation spotting to happen after fertilization, Dr. Nivin Todd on WebMD provides some helpful information on the steps that take place before implantation bleeding may happen:3

  1. Ovulation occurs about 2 weeks before the start of your next period.
  2. The egg moves into the fallopian tube and stays there for about 24 hours.
  3. If a sperm...

00:52

Negacin del Autismo Como Epidemia "IndyWatch Feed Health"

NOTE: Autism is a global epidemic. Adriana Gamondes has teamed up with Alberto Castra, in Argentina, to begin providing perspective from beyond our shores. Just as John Stone brings us the UK news, Adriana and Alberto will be adding more...

00:04

Experimental Herpes #Vaccine trials held offshore to avoid FDA guidelines. "IndyWatch Feed Health"

https://techcrunch.com/2017/08/29/peter-thiel-backs-offshore-human-testing-of-experimental-herpes-vaccine/

Sunday, 17 September

23:56

Alzheimers disease #vaccine on the horizon "IndyWatch Feed Health"

https://futurism.com/potential-vaccine-and-oral-medication-for-alzheimers-disease-in-human-trials/

23:52

BPA substituting chemicals may influence thyroid hormone homeostasis by affecting thyroid regulation and hormone synthesis. "IndyWatch Feed Health"

PMID:  Toxicol In Vitro. 2017 Apr ;40:297-304. Epub 2017 Feb 5. PMID: 28167136 Abstract Title:  Thyroid hormone disrupting potentials of bisphenol A and its analogues - in vitro comparison study employing rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Abstract:  As adverse health effects of bisphenol A (BPA) become a growing public health concern, the chemicals substituting BPA have been increasingly used in everyday lives. BPA substitutes have been frequently detected in both environment and biota in increasing levels. However, very limited toxicological information is available for these chemicals. In the present study, thyroid disrupting effects of nine structural analogues of BPA were evaluated along with BPA, using rat pituitary (GH3) and thyroid follicular (FRTL-5) cells. Similar to BPA, its analogues caused significant down-regulation of tsh, tr, tr, dio1 or dio2 genes in GH3 cells, and some analogues, such as BPF, BPM or BPZ, showed even greater potency compared to BPA. In FRTL-5 cells, the genes responsible for hormone synthesis, e.g., pax8, nis, tg or tpo genes, exhibited over 1.5-fold up-regulation following exposure to BPA analogues, such as BPS. The effects on gene regulation was different by the cell line. Our results clearly show that the BPA substituting chemicals may influence thyroid hormone homeostasis by affecting thyroid regulation and hormone synthesis, often at lower doses compared to BPA. Thyroid effects ofthe BPA analogues deserve further investigations in experimental organisms and in human populations.

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01:17

Geoengineering Creating Freeze Fry Extremes "IndyWatch Feed Health"

GeoengineeringWatch.org 11276Dane Wigington GeoengineeringWatch.org Global climate engineering operations are creating ever more extreme weather and temperature whiplash scenarios. The immense scale of climate forcing being carried out by the geoengineers is wreaking havoc on the biosphere. Over 70 years of covert climate intervention and weather warfare (along with countless other forms of anthropogenic activity) has done unimaginable

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