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PMID: Dermatol Ther (Heidelb). 2016 Jun ;6(2):287-98. Epub 2016 Mar 17. PMID: 26988991 Abstract Title: Injection Site Lichenoid Dermatitis Following Pneumococcal Vaccination: Report and Review of Cutaneous Conditions Occurring at Vaccination Sites. Abstract: BACKGROUND: Cutaneous dermatoses and malignancies have occurred at the sites of vaccines.PURPOSE: To describe a man who developed a lichenoid dermatitis at the pneumococcal vaccine injection site and to review cutaneous dermatoses and malignancies occurring at vaccination sites.METHODS: PubMed was used to search the following terms, separately and in combination: adverse, condition, cutaneous, dermatosis, dermatitis, injection, PCV13, pneumococcal, pneumonia, prevnar, reaction, skin, site, vaccination, and vaccine. All papers were reviewed, and relevant manuscripts, along with their reference citations, were evaluated.RESULTS: Several vaccines-including bacillus Calmette-Guerin, hepatitis B, influenza, leishmaniasis, meningitis, pneumococcal, smallpox, tetanus (alone and in combination with diphtheria, pertussis, polio, Haemophilus influenza type B or plague and yellow fever), and varicella-zoster-have been associated with post-vaccination site reactions. A 70-year-old male developed a lichenoid dermatitis that occurred at the pneumococcal vaccine injection site within 2 weeks after PCV13 vaccination; the erythematous nodule resolved spontaneously within 9 weeks following immunization.CONCLUSIONS: Dermatoses at the injection sites of vaccines can be granulomatous, immunity-related conditions, infections, lichenoid, neutrophilic, or pseudolymphomatous. Basal cell carcinoma and squamous cell carcinoma are the most common vaccination site-associated malignancies; however, melanoma and sarcomas (dermatofibrosarcoma protuberans, fibrosarcoma, and malignant fibrous histiocytoma) are also smallpox vaccine-related site neoplasms. A cutaneous immunocompromised district that is created by vaccine-induced local immunologic changes is hypothesized to be the pathogenesis of vaccination site reactions.
PMID: Obstet Gynecol. 2009 Feb ;113(2 Pt 2):550-2. PMID: 19155953 Abstract Title: Cervical cancers after human papillomavirus vaccination. Abstract: BACKGROUND: Current randomized clinical trials have shown that the quadrivalent human papillomavirus (HPV) vaccine can reduce the morbidity of precancerous lesions associated with HPV infection of vaccine-related subtypes. However, to date, there is no definite evidence showing the vaccine reduces the incidence of invasive cervical carcinoma.CASES: We present two cases--one young, vaccinated woman who developed cervical carcinoma that was unrelated to HPV and another who developed cervical carcinoma secondary to infection with an HPV subtype not covered by the vaccine. Both patients were treated successfully and remained well without evidence of cancer.CONCLUSION: Long-term follow-up data are needed to evaluate the prophylactic effectiveness of the current HPV vaccine. These cases could represent non-vaccine-related HPV infections. Young women must be thoroughly counseled about the efficacy and limitations of the vaccine and about continuing lifelong screening even after vaccination.
PMID: Med Cutan Ibero Lat Am. 1988 ;16(2):137-9. PMID: 3050329 Abstract Title: [Basocellular carcinoma in a smallpox vaccination scar]. Abstract: A 52 year old housewife was vaccinated against smallpox at the age of 18, on her right deltoid area. At the age of 50 she noticed erythema and scaling on the vaccination scar and 2 years later a nodule appear that enlarged during the following 3 months. There was no history nor skin changes suggestive of significant sun exposure. The histological examination of an initial biopsy and of the subsequently excised lesion revealed a basal cell carcinoma of the solid type. The relevant literature was reviewed and discussed with emphasis on sex and age incidence, age and site of vaccination, free interval between inoculation and tumor appearance, coexistence or not of other sun induced neoplasias and precancerous lesions and other possibly relevant clinical and etiopathogenetic aspects.
PMID: J Dermatol Surg. 1976 May ;2(2):151-2. PMID: 932293 Abstract Title: Basal-cell epithelioma occurring in a smallpox vaccination scar. Abstract: A patient with basal-cell epithelioma occurring in a smallpox vaccination site is reported. The association is probably not a chance occurrence.
PMID: Biologicals. 2008 Jan ;36(1):65-72. Epub 2007 Oct 22. PMID: 17933552 Abstract Title: Assessing the tumorigenic phenotype of VERO cells in adult and newborn nude mice. Abstract: VERO cell lines are important substrates for viral vaccine manufacture. The mechanism by which these cells became neoplastically transformed is unknown. During tissue-culture passage, VERO cells can develop the capacity to form tumors. Although at the passage levels (around p140) currently used for vaccine manufacture, VERO cells are non-tumorigenic, questions have been raised about safety issues that might be associated with this capacity to acquire a tumorigenic phenotype. To begin to address these issues, the tumorigenicity of VERO cell lines, derived at different passage levels under different growth conditions, were evaluated in 365-day assays in adult and newborn nude mice. High passage (p>200) VERO cell lines established by random passaging in tissue culture produced tumors in adult (10 out of 27) mice and newborn (21 out of 30) mice, respectively. In contrast, a high passage (p>250) cell line established by passage at sub-confluence produced tumors only in newborn mice (16 out of 30). Progressively growing tumors began forming at 36 days in newborns and at 69 days in adults. Higher tumor incidences and shorter tumor latencies suggest that newborn nude mice may be more sensitive than adults in detecting the expression of a tumorigenic phenotype by some VERO cell lines.
PMID: In Vitro Cell Dev Biol. 1985 Nov ;21(11):649-52. PMID: 4066602 Abstract Title: Activation of metastatic potential in African green monkey kidney cell lines by prolonged in vitro culture. Abstract: Studies on the tumorigenicity of Vero kidney cells of Cercopithecus aethiops monkey origin were extended to various passage levels of BSC-1 aneuploid cells and to low passage CV-1 diploid cells (derived also from C. aethiops monkey kidney). It was found that BSC-1 cells -- like Vero cells -- showed increased tumorigenicity with increasing passage level in antithymocyte globulin (ATG) treated newborn rats and in nude mice. Cells passaged over 250 times in cultures formed invasive adenocarcinomas in newborn rats. Their malignant tumor growth was further demonstrated around the 500 passage level when tumor metastases were detected in the lungs of four of the 14 inoculated rats. Vero cells induced such lung metastases in rats already at passage 227. CV-1 diploid cells at low passage level produced small nodules of epithelioid cells in newborn rats at 6th day after inoculation that had disappeared by the 21st day, and caused no local invasion nor lung metastasis. In vitro tumorigenicity tests on BSC-1 and CV-1 cells, using chick embryo skin, human muscle and colony formation in agarose, confirmed the animal test results. The results of this study indicate that BSC-1 and Vero cell lines at low and high passage levels may prove to be useful tools to study the molecular basis of malignancy.
PMID: MMWR Morb Mortal Wkly Rep. 2010 Feb 12 ;59(5):130-2. PMID: 20150888 Abstract Title: Transmission of yellow fever vaccine virus through breast-feeding - Brazil, 2009. Abstract: In April, 2009, the state health department of Rio Grande do Sul, Brazil, was notified by the Cachoeira do Sul municipal health department of a case of meningoencephalitis requiring hospitalization in an infant whose mother recently had received yellow fever vaccine during a postpartum visit. The Field Epidemiology Training Program of the Secretariat of Surveillance in Health of the Brazilian Ministry of Health assisted state and municipal health departments with an investigation. This report summarizes the results of that investigation, which determined that the infant acquired yellow fever vaccine virus through breast-feeding. The mother reported 2 days of headache, malaise, and low fever occurring 5 days after receipt of yellow fever vaccine. The infant, who was exclusively breast-fed, was hospitalized at age 23 days with seizures requiring continuous infusion of intravenous anticonvulsants. The infant received antimicrobial and antiviral treatment for meningoencephalitis. The presence of 17DD yellow fever virus was detected by reverse transcription--polymerase chain reaction (RT-PCR) in the infant's cerebrospinal fluid (CSF); yellow fever--specific immunoglobulin M (IgM) antibodies also were present in serum and CSF. The infant recovered completely, was discharged after 24 days of hospitalization, and has had normal neurodevelopment and growth through age 6 months. The findings in this report provide documentation that yellow fever vaccine virus can be transmitted via breast-feeding. Administration of yellow fever vaccine to breast-feeding women should be avoided except in situations where exposure to yellow fever viruses cannot be avoided or postponed.
The Australian documentary, The Monsanto Papers, reveals the secret tactics used by global chemical giant Monsanto (now owned by Bayer AG), to protect its best-selling herbicide, Roundup. The film starts out with a quick history of Roundup and how its now-clearly absurd safety claims (such as its biodegradable, safe enough to drink, and safer than 
(Note from Erin: Hey guys, so that no one accuses us of not being fully transparent, Dr. Dena Churchill is an acquaintance of ours via Facebook. Read on.) Chiropractor Dr. Dena Churchill is currently under investigation by the governing body for her profession in Canada and was recently ordered to shut down her practice. On Tuesday, Churchill 
A Washington school has pulled 38 students for failing to produce chickenpox vaccine documentation. A spokesperson for Battle Ground Public Schools says there are five confirmed cases of the illness. They believe that both staff...
The post 38 Unvaccinated Kids Removed From Washington School appeared first on Vaxxter.
Dane Wigington GeoengineeringWatch.org How is the global economy really doing? How is the state of the environment directly connected to the economy? The oceans are now filled with trash, what are all the sources of this trash? The largest science panel in the world says we "could" pass major climate tipping points in a decade or less. Is
CBD has gone mainstream this is nullification in action.
If there was ever any doubt, it completely vanished last month when Consumer Reports ran an article titled How to Shop for CBD. You dont get much more mainstream than Consumer Reports.
Cannabidiol (CBD) is derived from cannabis generally in the form of industrial hemp. It has proven effective in treating a number of medical conditions, including seizures, pain and anxiety.
Articles touting CBD have appeared in the mainstream media. For instance, the Washington Post called it the new it drug. And a recent CNN article called CBD, The latest it ingredient to hit menus. The report went on to tell us where we can get CBD infused food and drink
From a sleek, wellness compound in Miami to a Portland dive bar know...
By Meadow Clark
Yes, the rumors are true. California lawmakers passed a state law that forces restaurants within the state to offer only select beverages on childrens menus. Governor Jerry Brown signed SB 1192 into law in late September and it easily passed in both the State and the Assembly. Support for the nanny state law flew under the guise of whats healthiest for the children.
The default options for beverages on childrens menus have been forced to change to unflavored milk and water.
In other words, one more option than a dungeon.
Please understand that we arent promoting giving children HFCS-laden sodas on a regular basis, but we ARE promoting parental choice. Adamantly.
Customers can order another drink for their child by request, but clearly, the point of the law is to make it difficult (and frowned upon) to order something unhealthy for their child. Thats how nanny-state health laws are usually created. In increments or with fines or taxes (see more below), and usually with some kind of societal shame tactic.
Non-dairy fluid milk substitutes containing under 130 calories can also appear as an option on the menu if that kind of drink is available at the restaura...
Humans have been evolving on Planet Earth for many thousands of years enjoying an environment free of man-made electromagnetic (EMF) and radiofrequency (RF) pollution, often referred to as Electric Smog. Most folks are familiar with environmental pollution especially when theres a caustic haze hanging overhead and breathing becomes difficult for many people, especially those with allergies, heart and lung diseases. That man-made environmental pollution, also referred to as anthropogenic pollution, is caused or influenced by humans. Its palpable; we can see, smell and often react to it.
Specific classifications of pollution include water, soil, noise, radioactive, light, thermal and visual. However, one very dramatic type of pollution is ignored by those who really ought to know better; its non-thermal pollution emitted by EMFs and RFs from technologies, special satellites in orbit around Earth, smart devices and smart consumer products which, unfortunately, most people have become addicted to. Try leaving your iPhone at home! How many times an hour do you check your phone?
Since we are living in the Information / Computer / Digital Technological Age, everything and anything that can be invented and mainstreamed as smart has captured not only our imagination but our lifestyles, but not without a price to pay health-wisesomething very few probably fail to realize.
Technology does what it does because it can, not because it is safe in most instances or is used safely!
Classic examples are AMI Smart Meters placed on homes to monitor and measure utility usage for electricity, natural gas and municipal water. AMI SMs replace safe, analog meters tha...
Before we present this weeks Weekend Reads, a question: Do you enjoy our weekly roundup? If so, we could really use your help. Would you consider a tax-deductible donation to support Weekend Reads, and our daily work? Thanks in advance. The week at Retraction Watch featured a call for more than 30 retractions by former Harvard Continue reading Weekend reads: A whistleblower speaks; a new most-cited retracted paper; criminalizing scientific fraud?
Managing Editor's Note: So maybe I used a bit of clickbait... But the headline is technically true! True! True! We run this article from 2010 each Fall during the Flu Shot push that is everywhere. CVS? Earn a 20% savings...
From the APA Div. 32: Society for Humanistic Psychology: On Oct. 9-10, 2018, World Mental Health Day, the United Kingdom (UK) government hosted a Global Mental Health Ministerial Summit with the intention of laying out a course of action to implement mental health policies globally. In the same week, The Lancet Commission on Global Mental Health and Sustainable Development published a report outlining a proposal for scaling up mental health care globally. In response, a coalition of mental health activists and service-users have organized an open letter detailing their concerns with the summit and report. The response has attracted the support of policy-makers, psychologists, psychiatrists and researchers.
The open letter raises several concerns with the positioning of the UK summit and calls on the organizers and leaders of the event to reflect on issues of discrimination and human rights abuses in mental health treatment in their home countries before recreating these systems abroad. The signatories raise the issue of representation and participation, writing:
Significantly, there has been little or no involvement of organizations led by mental health service users, survivors and persons with psychosocial disabilities in the thinking, planning and design of this event. While a few networks were approached to provide experts by experiences to attend panels on themes already decided on, there has been no meaningful consultation or involvement of user-led and disabled peoples organizations not already signed up to the Movement for Global Mental Health agenda or funding to enable a wide range of representatives to attend.'
Today, we bring you the second in our series of podcasts on the topic of the global mental health movement. These interviews are led by our Mad in America research news team.
On October 9th and 10th, 2018, World Mental Health Day, the UK government hosted a Global Mental Health Ministerial Summit with the intention of laying out a course of action to implement mental health policies globally. In the same week, The Lancet Commission on Global Mental Health and Sustainable Development published a report outlining a proposal for scaling up mental health care globally. In response, a coalition of mental health activists and service-users have organized an open letter detailing their concerns with the summit and report. The response has attracted the support of policy-makers, psychologists, psychiatrists, and researchers.
In our last episode, we were joined by Dr Melissa Raven, a critical psychologist and epidemiologist, who discussed problems with the scientific evidence base used by the global mental health movement. She also emphasized the need to consider responses to the distress and suffering of people globally that address the social determinants of mental health, including poverty, education, and healthcare.
Today we turn our focus to the concerns raised by mental health activists in response to the UK summit and the Lancet report. To discuss these issues, we are joined first by Jhilmil Breckenridge, a poet, writer and mental health activist and later by social science researcher Dr Bhargavi Davar.
Jhilmil is the Founder of Bhor Foundation, an Indian charity, which is active in mental health advocacy, the trauma-informed approach, and enabling other choices to heal apart from the biomedical model. Jhilmil also heads a team leading Mad in Asia Pacific; this is an online webzine working for better rights, justice and inclusion for people with psychosocial disability in the Asia Pacific region. She is currently working on a PhD in Creative Writing in the UK and, for the last three years, she has also been leading an online poetry as therapy group for women recovering from domestic violence. She is working on a few initiatives, both in the UK and India, taking this approach into prisons and as...
PMID: JAMA. 2004 Feb 11 ;291(6):725-7. PMID: 14871916 Abstract Title: Tertiary contact vaccinia in a breastfeeding infant. Abstract: On May 4, 2003, a US Army soldier received primary smallpox vaccination and experienced a primary uptake reaction at the inoculation site on days 6 through 8. The vaccinee reported observing all of the standard precautions to avoid household spread. In mid May, his breastfeeding wife developed vesicles on both areolas. On May 29, their infant daughter developed a papule on her philtrum. Contact vaccinia was confirmed by positive polymerase chain reaction and culture for vaccinia of both the maternal and infant lesions. This is the first documented case of inadvertent contact vaccinia transmission from a mother to her infant through direct skin-to-skin and skin-to-mucous membrane contact while breastfeeding. The mechanism of transfer from the vaccinee to the spouse is uncertain. This report demonstrates that breastfeeding infants living in close contact with smallpox vaccinees are at potential risk for contact vaccinia, even if the vaccinee is not the breastfeeding mother, and highlights the need for special precautions to prevent secondary transfer to breastfeeding mothers.
PMID: J Infect Dis. 1985 Sep ;152(3):606-12. PMID: 4031558 Abstract Title: Postpartum rubella immunization: association with development of prolonged arthritis, neurological sequelae, and chronic rubella viremia. Abstract: Six women developed chronic long-term arthropathy after postpartum immunization against rubella. All individuals developed acute polyarticular arthritis within 12 days to three weeks postimmunization and have had continuing chronic or recurrent arthralgia or arthritis for two to seven years after vaccination. Acute neurological manifestations, consisting of carpal tunnel syndrome or multiple paresthesiae, developed postvaccination in three women. Two have developed continuing active or chronic recurrent episodes of blurred vision, paresthesiae, and painful limb syndromes together with recurrent joint symptoms. Chronic rubella viremia has been detected in peripheral blood mononuclear cell (MNC) populations in five of the six women up to six years after vaccination. In addition rubella virus was isolated from breast milk MNCs in one individual at nine months postvaccination and from peripheral blood MNCs in two of four breast-fed infants studied at 12-18 months of age. Immune responses to rubella virus studied at sequential intervals after vaccination correlated with development of rheumatologic and neurological manifestations.
PMID: J Pediatr (Rio J). 2011 May-Jun 8;87(3):269-72. Epub 2011 Apr 1. PMID: 21461453 Abstract Title: Infant meningoencephalitis caused by yellow fever vaccine virus transmitted via breastmilk. Abstract: OBJECTIVE: To describe a case of infant meningoencephalitis that was probably caused by yellow fever vaccine virus transmitted via breastmilk.DESCRIPTION: A 38-day old patient was admitted to hospital on May 23, 2009, with fever. On May 25, 2009, convulsive crises began. Cerebrospinal fluid (CSF) test results were suggestive of meningoencephalitis. The mother had been given a dose of yellow fever vaccine and the baby was on exclusive breastfeeding. The baby was discharged after the convulsive crises were controlled. Tests identified IgM antibodies specific for yellow fever in both serum and CSF.COMMENTS: In 2009, the first case was confirmed of meningoencephalitis caused by the yellow fever vaccine virus transmitted via breastmilk. We describe a second case in which the vaccine virus was possibly the etiologic agent of meningoencephalitis. The Brazilian Ministry of Health now recommends delaying vaccination of nursing mothers until their children reach 6 months or providing them with guidance on alternative options to avoid the risk of transmission of the vaccine virus via breastmilk.
PMID: J Infect Dis. 1982 May ;145(5):654-60. PMID: 7077089 Abstract Title: Effect of immunization against rubella on lactation products. I. Development and characterization of specific immunologic reactivity in breast milk. Abstract: The development of an immune response to rubella virus in milk, serum, and nasopharyngeal secretions was studied in lactating postpartum women after immunization with HPV-77 De5 or RA 27/3 live, attenuated rubella virus vaccine administered subcutaneously or intranasally. Over 69% of the women shed virus in milk after immunization. A predictable nasopharyngeal IgA and serum IgG antibody response to rubella virus was observed after subcutaneous or intranasal immunization with RA 27/3 vaccine. Little or no nasopharyngeal antibody response was seen after subcutaneous immunization with HPV-77 DE5 vaccine. A virus-specific IgA antibody response in milk was seen in all women. The presence of rubella virus in breast milk seemed to potentiate the peak levels of virus-specific antibody in the milk. Cellular immune reactivity to rubella virus in milk was observed in all vaccine groups. Thus, the virus-specific immune response induced in human milk after immunization with rubella virus vaccine may be intimately linked with the reactivity in bronchial lymphoid tissue.
An article published in Readers Digest1 suggests you are at a greater risk for certain negative health and life outcomes if you are left-handed, including accidents, certain mental and physical problems and even early death.
While its obvious left-handers face challenges with respect to using everyday items like keyboards, notebooks, scissors and zippers, which are typically designed to favor right-handed users, does research support the notion left-handedness is actually dangerous to your health?
Handedness your tendency to be more comfortable and skilled using one hand more than the other for tasks like dressing, throwing a ball or writing is a complex matter. Although you may think it is determined solely by genetics, handedness is a complex trait influenced by multiple factors, such as chance, environment and genetics.
According to the U.S. National Institutes of Health (NIH),2 the development of handedness begins before birth and is influenced by genes, as well as both your right-left asymmetry and the right and left hemispheres of your brain. They state:3
It was initially thought a single gene controlled handedness. However, more recent studies suggest multiple genes, perhaps up to 40, contribute to this trait. Each of these genes likely has a weak effect by itself, but together they play a significant role in establishing hand preference.
Studies suggest at least some of these genes help determine the overall right-left asymmetry of the body starting in the earliest stages of development.
Science Daily highlights asymmetry as an important feature of your brain, noting the left side usually controls speech and language, while the right side controls emotion. They assert, In left-handers this pattern is often reversed.
There is also evidence that asymmetry of the brain was an important feature during human evolution; the brains of our closest relatives, the apes, are more symmetrical than those of humans and apes do not show a strong handedness.4 Authors of a 2013 study published in the journal Neurosci...
The film starts out with a quick history of Roundup and how its now-clearly absurd safety claims (such as "it's biodegradable," "safe enough to drink," and "safer than table salt") made it into the worlds' most widely used weed killer, used by farmers and private gardeners alike. Indeed, it was at one time known as "the world's most trusted herbicide," but those days are now long gone.
Between 1974 the year glyphosate entered the U.S. market and 2014, glyphosate use increased more than 250fold in the U.S. Today, an estimated 300 million pounds are applied on U.S. farmland annually. Globally, nearly 5 billion pounds (over 2 billion kilograms) of glyphosate are applied to some 70 types of farm crops each year.3
Mounting evidence suggests Roundup is far from harmless, and evidence unearthed during legal discovery shows Monsanto has been well aware of its product's toxic nature, and has been covering it up.
As previously discussed in many articles, glyphosate and glyphosate-based weed killer formulations such as Roundup have in recent years been linked to a wide variety of human health consequences, including:...
Impairing your body's ability to produce fully functioning proteins5
Inhibiting the shikimate pathway (found in gut bacteria)
Interfering with the function of...
If youve ever looked into natural ways to improve your sleep, youve probably noticed that one of the most common herbal remedies used for this purpose is valerian (Valeriana officinalis). In fact, its been prescribed for insomnia since the second century A.D., and its other therapeutic uses were even described by Hippocrates.1
One of the most popular ways to reap the potential health benefits of valerian is by brewing it into a cup of tea. Read on to learn more about the properties of this relaxing beverage and what you should keep in mind before including it in your diet plan.
Valerian tea is derived from the dried roots of the valerian plant.2 Also known as natures valium, valerian is a perennial herb thats famous for its potent calming effect.3 Its native to Europe and Asia, but is also cultivated in America and China, among other countries.4
Valerian grows up to 5 feet tall and has sweet-smelling flowers that are white, lavender or pink.5 Unlike its flowers, the roots of the valerian plant from which the tea is made have a distinctive earthy scent that many people find unpleasant.6 This odor is caused by its volatile oils and active compounds.7
Despite valerian roots long history of use for medicinal applications, there is still no scientific agreement as to what specific compound is responsible for its sedative properties. Researchers suggest that its effects may be the result of the interaction between its chemical constituents.8
The ability of valerian root tea to help promote sleep quality and quantity is perhaps its most valued health benefit. This herbal concoction is usually consumed by people with sleeping disorders such as insomnia, since its sedative effect makes it a great natural alternative to sleeping pills....
PMID: Br Dent J. 2014 Jan ;216(2):69-71. PMID: 24457866 Abstract Title: Transient facial nerve paralysis (Bell's palsy) following administration of hepatitis B recombinant vaccine: a case report. Abstract: Bell's palsy is the sudden onset of unilateral transient paralysis of facial muscles resulting from dysfunction of the seventh cranial nerve. Presented here is a 26-year-old female patient with right lower motor neurone facial palsy following hepatitis B vaccination. Readers' attention is drawn to an uncommon cause of Bell's palsy, as a possible rare complication of hepatitis B vaccination, and steps taken to manage such a presentation.
PMID: BMJ. 2011 Oct 12 ;343:d5956. Epub 2011 Oct 12. PMID: 21994316 Abstract Title: Neurological and autoimmune disorders after vaccination against pandemic influenza A (H1N1) with a monovalent adjuvanted vaccine: population based cohort study in Stockholm, Sweden. Abstract: OBJECTIVE: To examine the risk of neurological and autoimmune disorders of special interest in people vaccinated against pandemic influenza A (H1N1) with Pandemrix (GlaxoSmithKline, Middlesex, UK) compared with unvaccinated people over 8-10 months.DESIGN: Retrospective cohort study linking individualised data on pandemic vaccinations to an inpatient and specialist database on healthcare utilisation in Stockholm county for follow-up during and after the pandemic period.SETTING: Stockholm county, Sweden. Population All people registered in Stockholm county on 1 October 2009 and who had lived in this region since 1 January 1998; 1,024,019 were vaccinated against H1N1 and 921,005 remained unvaccinated.MAIN OUTCOME MEASURES: Neurological and autoimmune diagnoses according to the European Medicines Agency strategy for monitoring of adverse events of special interest defined using ICD-10 codes for Guillain-Barr syndrome, Bell's palsy, multiple sclerosis, polyneuropathy, anaesthesia or hypoaesthesia, paraesthesia, narcolepsy (added), and autoimmune conditions such as rheumatoid arthritis, inflammatory bowel disease, and type 1 diabetes; and short term mortality according to vaccination status.RESULTS: Excess risks among vaccinated compared with unvaccinated people were of low magnitude for Bell's palsy (hazard ratio 1.25, 95% confidence interval 1.06 to 1.48) and paraesthesia (1.11, 1.00 to 1.23) after adjustment for age, sex, socioeconomic status, and healthcare utilisation. Risks for Guillain-Barr syndrome, multiple sclerosis, type 1 diabetes, and rheumatoid arthritis remained unchanged. The risks of paraesthesia and inflammatory bowel disease among those vaccinated in the early phase (within 45 days from 1 October 2009) of the vaccination campaign were significantly increased; the risk being increased within the first six weeks after vaccination. Those vaccinated in the early phase were at a slightly reduced risk of death than those who were unvaccinated (0.94, 0.91 to 0.98), whereas those vaccinated in the late phase had an overall reduced mortality (0.68, 0.64 to 0.71). These associations could be real or explained, partly or entirely, by residual confounding.CONCLUSIONS: Results for the safety of Pandemrix over 8-10 months of follow-up were reassuring -notably, no change in the risk for Guillain-Barr syndrome, multiple sclerosis, type 1 diabetes, or rheumatoid arthritis. Relative risks were significantly increased for Bell's palsy, paraesthesia, and inflammatory bowel disease after vaccination, p...
PMID: Ugeskr Laeger. 2014 Oct 13 ;176(42). PMID: 25316362 Abstract Title: [Squamous cell carcinoma in ulcer after bacille Calmette-Gurin vaccination]. Abstract: Marjolin's ulcer is an aggressive squamous cell carcinoma (SCC) found in chronically inflamed skin. SCC has been reported in smallpox vaccination sites, whereas basal cell carcinomas are more common in scar after bacille Calmette-Gurin (BCG) vaccination. A 72-year-old man presented with a chronic ulcer at the site of his childhood BCG vaccination. At the time of examination, a 3 1.5 cm fleshy and secreting ulcer was found on the shoulder. Biopsy revealed SCC, and the tumour was surgically removed. In conclusion, chronic ulcers, especially those originating in chronically inflamed skin, should be regularly biopsied to assure that malignant transformation has not occurred.
PMID: Rev Chir Orthop Reparatrice Appar Mot. 2006 Feb ;92(1):60-3. PMID: 16609619 Abstract Title: [Septic dislocation of the hip secondary to BCG vaccination]. Abstract: We report a case of septic dislocation of the hip in an eight-month-old infant secondary to BCG vaccination. The usual treatment of septic arthritis with surgical drainage and broad spectrum antibiotics was unsuccessful. Cure was achieved after institution of an anti-tuberculosis treatment and a second surgical drainage. This rare complication of BCG vaccination can develop several months after administration of the vaccine. Diagnosis is often difficult to establish due to the minimal clinical and non-specific clinical expression. Early radiological signs are also non-specific. Identification of the causal agent can be most difficult. Certain diagnosis is generally achieved after biopsy and pathology examination. Despite the attenuated virulence of the vaccine, anti-tuberculosis treatment is indispensable to achieve cure. Surgery drainage alone is insufficient.
PMID: Clin Exp Dermatol. 2009 Jul ;34(5):e167-9. Epub 2008 Dec 15. PMID: 19094126 Abstract Title: Lupus vulgaris at the site of BCG vaccination: report of three cases. Abstract: Lupus vulgaris (LV) is a rare complication of the bacille Calmette-Gurin (BCG) vaccination, and about 65 cases of inoculation tuberculosis resembling LV have been reported in the literature. We report three cases of LV, developing many years later at the inoculation site of BCG vaccine. All three cases had a single BCG vaccination, with a LV lesion at or in the vicinity of the vaccination site, a strong positive Mantoux test, noncaseating granuloma histologically, and two of the patients had a positive PCR result for mycobacterial complex. One of the patients had an unusually delayed appearance of the LV lesion, after an interval of about 17 years, and another case was remarkable because of the large size of the lesion (210 x 110 mm).
PMID: Klin Oczna. 2006 ;108(10-12):446-9. PMID: 17455724 Abstract Title: [The detachment of retina as possible complication after BCG vaccination during HOP--description of case]. Abstract: PURPOSE: The authors described the rare case of the progression of changes in the retina of child in course of retinopathy of prematurity. It happened after finished laser-treatment and full regression of changes of the retina. It seems that BCG vaccination done in 3-th month of life could reactivate the disease of the retina which caused total retina detachment of both eyes.MATERIAL AND METHODS: The ophthalmologic examination included: indirect ophthalmoscopy using Fisson ophthalmoscope, slit-lamp examination and USG B-mode examination, using USG Echo Scan 3300 Oculus with the head 10 MHz--performed during all control visits.RESULTS: The regular ophthalmologic examination enabled estimation of the dynamic of changes in the retina and correctness of treatment. In author's opinion, the secondary retina detachment in 3-th month of life could be associated with reaction post BCG vaccination.CONCLUSIONS: Probably secondary inflammation after BCG vaccination could be the reason of reactivation of earlier treated with good results ROP Possible vision complications should incline to take special ophthalmologic care of premature infants from high risk group (very low mass of the body or fetal immaturity). Decision of changing time of BCG vaccination in such group should be made by attending physician.
PMID: J Pediatr Ophthalmol Strabismus. 2008 Jul-Aug;45(4):252-3. PMID: 18705627 Abstract Title: Chronic anterior uveitis following bacille Calmette-Gurin vaccination: molecular mimicry in action? Abstract: A 13-year-old girl developed bilateral chronic anterior uveitis following bacille Calmette-Gurin (BCG) vaccination. HLA testing was negative for B27 but positive for DRB1 *0404, a variant of DR4 often associated with rheumatoid arthritis. The authors propose her HLA repertoire allowed for a BCG-induced abnormal autoimmune response by the mechanism of molecular mimicry.
PMID: J Forensic Sci. 2016 Jan ;61 Suppl 1:S259-64. Epub 2015 Sep 8. PMID: 26347043 Abstract Title: A Case of Sudden Infant Death Due to Incomplete Kawasaki Disease. Abstract: Although Kawasaki disease (KD) is a self-limiting disease, it may cause sudden cardiac death. Diagnosis of KD is principally based on clinical signs; however, some infant cases do not meet the criteria. Such cases are identified as incomplete KD. The sudden death risk in incomplete KD cases is similar to conventional KD. In our 5-month-old case, he had been admitted to a hospital for a fever and suppuration at the site of Bacille de Calmette et Guerin (BCG) vaccination. However, after discharge from the hospital, his C-reactive protein (CRP) levels declined, he got indisposed and died suddenly. A medico-legal autopsy revealed myocarditis, coronaritis, platelet-aggregated emboli in coronary arteries, and myocardial degeneration, suggesting that the fatal myocardial infarction was due to thrombus emboli in the coronary arteries. Forensic pathologists therefore should pay attention to the cardiac pathology originated from incomplete KD as a potential cause in cases of sudden infant death.
PMID: Int J Lepr Other Mycobact Dis. 1981 Mar ;49(1):16-20. PMID: 7195879 Abstract Title: Borderline tuberculoid leprosy following BCG vaccination. A case report. Abstract: Borderline tuberculoid leprosy was diagnosed clinically and histologically in a four year-old boy about 6 months after intradermal vaccination with BCG. His mother reported that a lesion began to appear above the vaccination site on the arm 2 weeks after the vaccination, and a second lesion appeared on the chin 2 months later. Responses in the lymphocyte transformation test to sonicated Mycobacterium leprae, BCG, and to PPD were consistent with a tuberculoid leprosy infection. Precipitation of BT leprosy by intradermal BCG infection may possibly represent the overcoming of a phase of primary suppression in an individual who might otherwise have progressed toward lepromatous leprosy. The implications of this hypothesis for the planning of a controlled trial of an anti-leprosy vaccine are discussed.
The Australian government and mainstream journalists are going to extreme lengths to prevent the public from receiving the science that supports the publics right to choice in vaccination, with credibility. This includes providing false and misleading information about my qualifications in public health and the framing of the scientific arguments as anti-vaccination or a conspiracy theory.
It is important to remember that vaccines are injected into the human body and, like all drugs, it is necessary to know what is injected and what the long-term health effects are. It is also important to know if governments are using objective science or biased science in the development of these policies.
This bias can be a result of the industry funding of vaccine science combined with the financial conflicts of interest of government representatives and the donations/lobbying of politicians by pharmaceutical companies.
My PhD research found that governments are promoting vaccines on 3 main myths:
Here is a 30 minute video presentation of the scientific evidence in my PhD that demonstrates that there is no valid reason to mandate any vaccine in any population. The mandating of vaccines is a serious risk to public health and it is most likely destroying the genetic fabric of the population. This video has been made for a scientific conference on vaccination and it is titled Vaccination against Multiple Diseases: Is this in the best interests of public health?
Please note that the control of infectious diseases is a discipline of public health (social medicine). It was not included in the field of medicine for general practitioners until the 1990s. Prior to this it was not a medical issue. This is because Infectious diseases were controlled by political and economic decisions that changed our lifestyle and environment with...
PMID: Indian J Tuberc. 2009 Apr ;56(2):104-7. PMID: 19810594 Abstract Title: Bcg induced mycobacterial spindle cell pseudotumor in an infant. Abstract: Mycobacterial Spindle cell Pseudotumor (MSP) is a rare complication of mycobacterial infection, especially the atypical variety. It is characterized by an exuberant spindle cell proliferation. This has been reported in the lymph nodes, skin, spleen, lungs, brain, etc. The incidence is higher in immuno-compromised patients, especially those with acquired immunodeficiency syndrome. It is rare to encounter this lesion in infants. We report a case of MSP in the axillary lymph node of a 7-month-old infant, following Bacillus Calmette Guerin (BCG) vaccination due to Mycobacterium tuberculosis complex, which was proved by PCR.
PMID: BMJ Case Rep. 2016 Mar 31 ;2016. Epub 2016 Mar 31. PMID: 27033285 Abstract Title: Bacillus Calmette-Gurin reactivation as a sign of incomplete Kawasaki disease. Abstract: Kawasaki disease (KD) is an acute, self-limited, systemic vasculitis of unknown aetiology, extremely rare in infants younger than 6 months old. Younger infants are more likely to present with incomplete KD (IKD) and are at higher risk of developing coronary abnormalities. An early and specific clinical sign, not included in the classical diagnosis criteria, but that can be very useful in the diagnosis of KD, is the reaction at the Bacillus Calmette-Gurin (BCG) inoculation site. We describe a case of a 4-month-old boy, fully immunised, whose BCG scar reactivation led to the diagnosis of IKD. This case-report emphasises the importance of BCG site reactivation in establishing a diagnosis of IKD that clinicians should be aware of, especially in countries where BCG vaccination is still part of the immunisation schedule.
PMID: Cent Eur J Public Health. 1995 Aug ;3(3):138-41. PMID: 8535371 Abstract Title: Adverse reactions to BCG. Abstract: In the post-war period the following BCG vaccines were successively in use for preventive vaccination in the Czech territory: (a) Copenhagen BCG, 1947-1950, (b) Prague BCG 725, 1951-1980, (c) Moscow BCG, 1981-1993, and (d) Behring BCG, from 1994 onwards. These BCG substrains can be now identified by modern methods of molecular genetics. Introducing the Moscow BCG brought about an elevated incidence of iatrogenic local and regional lymph node adverse reactions compared with the previous Prague BCG product and, as a new phenomenon, bone and joint involvements in children vaccinated at birth. The aim of this study was to analyze the incidence of postvaccination adverse reactions reported in the period from 1981 to 1993 as related to the Moscow BCG vaccine and, to demonstrate the effect of lower vaccination dosage on their frequency. The concentration of the Moscow BCG varied from 11 to 22.6 x 10(6) (average 16.2) CFU per 1 mg. In the period when full dose of BCG (0.05 mg per 0.1 ml) was applied to newborns 437 local and 195 regional lymph node complications were recorded, i.e. 0.08% of vaccinated were affected, demanding antituberculosis chemotherapy in 6.5% and surgical interventions in 24%. When the lowered vaccination dose (0.025 mg per 0.1 ml) was inoculated to newborns the local adverse reactions rose paradoxically affecting 0.1% of vaccinated but the regional lymph node reactions fell considerably to reach 0.01%; the demand for chemotherapy and surgery also fell down to 3.1 and 4.8% respectively. Bone and joint adverse involvements were recorded in 28 cases, i.e. in 3.7 per 10(5) of those vaccinated with the full dose.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID: Autoimmun Rev. 2017 Jul ;16(7):756-765. Epub 2017 May 5. PMID: 28483543 Abstract Title: Vaccinations and risk of systemic lupus erythematosus and rheumatoid arthritis: A systematic review and meta-analysis. Abstract: BACKGROUND: In the past several years, more and more studies proposed some concerns on the possibly increased risk of autoimmune diseases in individuals receiving vaccinations, but published studies on the associations of vaccinations with risks of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) reported conflicting findings. A systematic review and meta-analysis was carried out to comprehensively evaluate the relationship between vaccinations and risk of SLE and RA.METHODS: Pubmed, Web of Science and Embase were searched for observational studies assessing the associations of vaccinations with risks of RA and SLE. Two authors independently extracted data from those eligible studies. The quality of eligible studies was assessed by using the Newcastle-Ottawa Scale (NOS). The pooled relative risk (RR) with 95% confidence intervals (CIs) was used to measure the risk of RA and SLE associated with vaccinations, and was calculated through random-effect meta-analysis.RESULTS: Sixteen observational studies were finally considered eligible, including 12 studies on the association between vaccinations and SLE risk and 13 studies on the association between vaccinations and RA risk. The pooled findings suggested that vaccinations significantly increased risk of SLE (RR=1.50; 95%CI 1.05-2.12, P=0.02). In addition, there was an obvious association between vaccinations and increased risk of RA (RR=1.32; 95%CI 1.09-1.60, P=0.004). Meta-analysis of studies reporting outcomes of short vaccinated time also suggested that vaccinations could significantly increase risk of SLE (RR=1.93; 95%CI 1.07-3.48, P=0.028) and RA (RR=1.48; 95%CI 1.08-2.03, P=0.015). Sensitivity analyses in studies with low risk of bias also found obvious associations of vaccinations with increased risk of RA and SLE.CONCLUSION: This study suggests that vaccinations are related to increased risks of SLE and RA. More and larger observational studies are needed to further verify the findings above and to assess the associations of vaccinations with other rheumatic diseases.
PMID: J Drugs Dermatol. 2015 Jul ;14(7):681-4. PMID: 26151783 Abstract Title: Severe Autoimmune Adverse Events Post Herpes Zoster Vaccine: A Case-Control Study of Adverse Events in a National Database. Abstract: Zoster vaccine is recommended to reduce the incidence of herpes zoster and its complication of postherpetic neuralgia in older adults. However, there have been reports of autoimmune side effects post vaccination. We therefore aim to investigate the possible relationship of severe autoimmune adverse events (arthritis, vasculitis, systemic lupus erythematosus, thrombocytopenia, alopecia, Guillain-Barre syndrome, optic neuritis and multiple sclerosis) post zoster vaccination with a matched case-control study of reported events in the Vaccine Adverse Event Reporting System (VAERS). Our study showed no significantly increased risks of severe autoimmune adverse events, except arthritis and alopecia, after vaccination. Compared to the unexposed, patients with zoster vaccination had 2.2 and 2.7 times the odds of developing arthritis and alopecia, respectively (P
PMID: J Rheumatol. 1998 Sep ;25(9):1687-93. PMID: 9733447 Abstract Title: The development of rheumatoid arthritis after recombinant hepatitis B vaccination. Abstract: OBJECTIVE: Hepatitis B vaccination has been associated with reactive arthritis and rarely rheumatoid arthritis (RA). We defined the clinical, serologic, and immunogenetic background of patients developing RA, soon after recombinant hepatitis B vaccination.METHODS: The clinical, serologic, and HLA antigens of a cluster of firefighters who developed arthritis after prophylactic recombinant hepatitis B vaccination (5 subjects), as well as a second group of sporadic cases of arthritis (6 patients) after hepatitis B vaccination are described.RESULTS: Ten of 11 patients fulfilled revised American College of Rheumatology criteria for RA. All cases had persistent arthritis for more than 6 months; at 48 months followup 2 cases no longer had inflammatory arthritis. Nine patients required disease modifying antirheumatic drugs. Five subjects were HLA-DR4 positive. HLA class II genes expressing the RA shared motif were identified in 9/11 patients genotyped for HLA-DRbeta1 and DQbeta1 alleles (0401, 0101, or 0404). All the firefighters shared the HLA-DRbeta1 allele 0301 and the DQbeta1 allele 0201, with which it is in linkage disequilibrium.CONCLUSION: These polymorphic residues in the binding site of the MHC class II molecules of the affected patients appear capable of binding some peptide sequences of the recombinant vaccine peptides they received and may be responsible for hepatitis B vaccine triggering development of RA in these cases. Recombinant hepatitis B vaccine may trigger the development of RA in MHC class II genetically susceptible individuals.
PMID: Nihon Rinsho Meneki Gakkai Kaishi. 2016 ;39(2):145-9. PMID: 27212601 Abstract Title: A case of systemic lupus erythematosus (SLE) following Human papillomavirus (HPV) vaccination. Abstract: A 15-year-old young woman received the Human papillomavirus (HPV) vaccines. Following the second HPV vaccination, intermittent fever, myalgia, arthritis and malar rash developed, and she was admitted to our hospital. Laboratory studies showed positive results for antinuclear antibody, anti-dsDNA antibody and anti-Sm antibody. Systemic lupus erythematosus (SLE) was diagnosed according to the Systemic Lupus International Collaborative Clinics 2012. Magnetic resonance imaging showed abnormal hyperintense areas in the fascia, and en bloc biopsy showed fasciitis. Treatment with prednisolone resulted in an amelioration of the symptoms. Reportedly, SLE developed after HPV vaccinations in some patients. Most such patients have a past or family history of autoimmune disease and presented SLE symptoms after the second vaccination. We describe herein a patient in whom SLE developed in association with HPV vaccination.
PMID: Front Endocrinol (Lausanne). 2016 ;7:150. Epub 2017 Jan 24. PMID: 28167927 Abstract Title: Autoimmune/Inflammatory Syndrome Induced by Adjuvants and Thyroid Autoimmunity. Abstract: The autoimmune/inflammatory syndrome induced by adjuvants (ASIA), presented by Shoenfeld and Agmon-Levin in 2011, is an entity that incorporates diverse autoimmune conditions induced by the exposure to various adjuvants. Adjuvants are agents that entail the capability to induce immune reactions. Adjuvants are found in many vaccines and used mainly to increase the response to vaccination in the general population. Silicone has also been reported to be able to induce diverse immune reactions. Clinical cases and series of heterogeneous autoimmune conditions including systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis have been reported to be induced by several adjuvants. However, only a small number of cases of autoimmune thyroid disorder have been included under the umbrella of ASIA syndrome. Indeed, clinical cases of Hashimoto's thyroiditis and/or subacute thyroiditis were observed after the exposure to vaccines as well as silicone implantation. In our review, we aimed to summarize the current knowledge on ASIA syndrome presented as endocrinopathies, focusing on autoimmune thyroid disorders associated with the various adjuvants.
PMID: Immunol Res. 2017 02 ;65(1):55-65. PMID: 27417999 Abstract Title: Adjuvants- and vaccines-induced autoimmunity: animal models. Abstract: The emergence of autoimmunity after vaccination has been described in many case reports and series. Everyday there is more evidence that this relationship is more than casual. In humans, adjuvants can induce non-specific constitutional, musculoskeletal or neurological clinical manifestations and in certain cases can lead to the appearance or acceleration of an autoimmune disease in a subject with genetic susceptibility. The fact that vaccines and adjuvants can trigger a pathogenic autoimmune response is corroborated by animal models. The use of animal models has enabled the study of the effects of application of adjuvants in a homogeneous population with certain genetic backgrounds. In some cases, adjuvants may trigger generalized autoimmune response, resulting in multiple auto-antibodies, but sometimes they can reproduce human autoimmune diseases including rheumatoid arthritis, systemic lupus erythematosus, Sjgren syndrome, autoimmune thyroiditis and antiphospholipid syndrome and may provide insights about the potential adverse effects of adjuvants. Likewise, they give information about the clinical, immunological and histologic characteristics of autoimmune diseases in many organs, especially secondary lymphoid tissue. Through the description of the physiopathological characteristics of autoimmune diseases reproduced in animal models, new treatment targets can be described and maybe in the future, we will be able to recognize some high-risk population in whom the avoidance of certain adjuvants can reduce the incidence of autoimmune diseases, which typically results in high morbidity and mortality in young people. Herein, we describe the main animal models that can reproduce human autoimmune diseases with emphasis in how they are similar to human conditions.
PMID: Ophthalmology. 2002 Jan ;109(1):99-104. PMID: 11772587 Abstract Title: Optic neuritis after anthrax vaccination. Abstract: OBJECTIVE: To report the occurrence of optic neuritis after anthrax vaccination in two patients.DESIGN: Observational case reports, review of literature.METHODS: Description of clinical history, examination, neuroimaging, and further studies in two patients experiencing optic neuritis in temporal association with anthrax vaccination.MAIN OUTCOME MEASURES: Visual acuity, visual fields.RESULTS: Two patients, 39 and 23 years of age, were seen with acute optic neuritis 1 month and 2 weeks, respectively, after anthrax booster vaccination and successfully treated with intravenous methylprednisolone. The first patient had a typical presentation and course of unilateral retrobulbar optic neuritis with excellent visual recovery. The second patient had a bilateral anterior optic neuritis and has required chronic immunosuppression to maintain his vision. Retinal and optic nerve autoantibodies were present in the second patient. No cross-reactive epitopes between anthrax vaccine and retina/optic nerve were identified.CONCLUSION: Optic neuritis is a potential adverse reaction of anthrax vaccination.
PMID: J Toxicol Clin Toxicol. 2001 ;39(1):81-4. PMID: 11327232 Abstract Title: Delayed life-threatening reaction to anthrax vaccine. Abstract: BACKGROUND: Anthrax is an acute infectious disease caused by the spore-forming bacterium Bacillus anthracis. Due to the current world threat of unpredictable biological terrorism, the Department of Defense has mandated the systematic vaccination of all US military personnel against this warfare agent. Many may experience al mild flu-like illness and soreness at the injection site, but systemic reactions are rare.CASE REPORT: We report a delayed and potentially serious life-threatening adverse reaction to anthrax vaccine. A previously healthy 34-year-old male was transported to the emergency department with dyspnea, diaphoresis, pallor, and urticarial wheals on his face, arms, and torso after the administration of the third dose of anthrax vaccine. All symptoms resolved after pharmacological intervention and the patient was discharged. Pharmaco-epidemiological data indicate that 30% of anthrax vaccine recipients experience mild local reactions. With large numbers of military personnel being vaccinated, emergency physicians may encounter more vaccine-related adverse reactions.
PMID: Int J Clin Pharm. 2015 Feb ;37(1):23-6. Epub 2014 Dec 17. PMID: 25515616 Abstract Title: Drug-induced anaemia: a decade review of reporting to the Italian Pharmacovigilance data-base. Abstract: BACKGROUND: Studies investigating drug-induced anaemia are relatively scarce and mostly related to specific drugs or patients with specific pathologies.OBJECTIVE: To analyse all reports of suspected drug-induced anaemias recorded in the National Pharmacovigilance Database of the Italian Medicines Agency.METHOD: The cases of suspected drug-induced anaemias analysed were those retrieved from the Italian National Pharmacovigilance Database from January 2001 to December 2013.RESULTS: The active substances involved were 375 in 3,305 reports of drug-induced anaemia; of these, 72 % were reported as serious. In 35 % of the reports patients were in polytherapy. In 24.3 % of the cases relevant DDIs were identified. We found a PRR value of 57.29 for peginterferon alfa-2a, of 12.57 for ribavirin, of 13 for flu vaccine for the occurrence of autoimmune haemolytic anaemia. The drugs mostly involved in the cases where the Naranjo causality was probable or possible were acetylsalicylic acid, warfarin, ribavirin, peginterferon alfa-2a, carboplatin and acenocoumarol.CONCLUSIONS: A possible signal was detected for peginterferon alfa-2a, ribavirin and flu vaccine in the occurrence of autoimmune haemolytic anaemia. A great involvement of clopidogrel, enoxaparin, warfarin, ticlopidine and acetylsalicylic acid in preventable DDI-induced anaemia was detected, highlighting a poor awareness among healthcare providers on this issue.
PMID: J Emerg Med. 2013 Feb ;44(2):e149-51. Epub 2012 Jul 15. PMID: 22796025 Abstract Title: A case of Evans' syndrome following influenza vaccine. Abstract: BACKGROUND: Evans' syndrome is an uncommon condition defined by the combination (either simultaneously or sequentially) of immune thrombocytopenia purpura and autoimmune hemolytic anemia with a positive direct antiglobulin test in the absence of known underlying etiology.OBJECTIVES: We present a case of Evans' syndrome following influenza vaccination.CASE REPORT: A 50-year-old man with no prior medical history developed Evans' syndrome 4 days after receiving influenza immunization. The patient improved following treatment with oral prednisone and intravenous immunoglobulin.CONCLUSION: Influenza vaccine is one of the most commonly used vaccines worldwide, with millions of people being vaccinated annually. Despite its wide use, only sparse information has been published concerning any hematological effects of this vaccine. The rarity of such effects supports the safety of using this vaccine.
PMID: Beitr Pathol. 1976 Jul ;158(2):212-24. PMID: 985298 Abstract Title: Lethal complications of typhoid-cholera-vaccination. (Case report and review of the literature). Abstract: Simultaneous parenteral vaccination against typhoid and cholera lead to death through either anaphylactic shock or endotoxic shock in a 36-year-old male. At autopsy the charactertic features of shock as well as chronic interstitial myocarditis were noted. Moreover, fresh histiocytic and lymphocytic nodules were found in the liver, heart and meninges. A review of the literature dealing with lethal complications following parenteral tyhoid vaccinations shows an increased risk in debilitated persons (emaciation, stress, cold). Most of the fatalities occurred in persons who had previous disturbances of the cardiovascular system, as in the case reviewed here. Cardiac failure, Landry's paralysis, renal failure and disturbances of skin, joints and intestines may also follow typhoid vaccinations. However, these latter complications are usually not lethal. The patients presented here had many of the conditions which are known to aggravate the situation and to lead to a lethal culmination. The review of this case and the disucussion following it shows that only healthy persons should receive the parenteral typhoid vaccination. Hopefully, the presentation of this material will help prevent fatalities of this type in the future.
PMID: BMJ. 2008 Dec 2 ;337:a2642. Epub 2008 Dec 2. PMID: 19050332 Abstract Title: Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls: retrospective cohort study. Abstract: OBJECTIVE: To describe the outcomes of clinical evaluation, skin testing, and vaccine challenge in adolescent schoolgirls with suspected hypersensitivity to the quadrivalent human papillomavirus vaccine introduced in Australian schools in 2007.DESIGN: Retrospective cohort study.SETTING: Two tertiary paediatric allergy centres in Victoria and South Australia, Australia.PARTICIPANTS: 35 schoolgirls aged 12 to 18.9 years with suspected hypersensitivity reactions to the quadrivalent human papillomavirus vaccine.MAIN OUTCOME MEASURES: Clinical review and skin prick and intradermal testing with the quadrivalent vaccine and subsequent challenge with the vaccine.RESULTS: 35 schoolgirls with suspected hypersensitivity to the quadrivalent human papillomavirus vaccine were notified to the specialised immunisation services in 2007, after more than 380 000 doses had been administered in schools. Of these 35 schoolgirls, 25 agreed to further evaluation. Twenty three (92%) experienced reactions after the first dose. Thirteen (52%) experienced urticaria or angio-oedema, and of these, two experienced anaphylaxis. Thirteen had generalised rash, one with angio-oedema. The median time to reaction was 90 minutes. Nineteen (76%) underwent skin testing with the quadrivalent vaccine: all were skin prick test negative and one was intradermal test positive. Eighteen (72%) were subsequently challenged with the quadrivalent vaccine and three (12%) elected to receive the bivalent vaccine. Seventeen tolerated the challenge and one reported limited urticaria four hours after the vaccine had been administered. Only three of the 25 schoolgirls were found to have probable hypersensitivity to the quadrivalent vaccine.CONCLUSION: True hypersensitivity to the quadrivalent human papillomavirus vaccine in Australian schoolgirls was uncommon and most tolerated subsequent doses.
PMID: Ann Med Health Sci Res. 2014 Nov ;4(6):829-36. PMID: 25506472 Abstract Title: Hepatitis B vaccination and associated oral manifestations: a non-systematic review of literature and case reports. Abstract: Hepatitis B vaccine has been administered in children and adults routinely to reduce the incidence of the disease. Even though, hepatitis B vaccine is considered as highly safe, some adverse reactions have been reported. A literature search was carried out in PubMed, accessed via the National Library of Medicine PubMed interface, searching used the following keywords: Hepatitis B vaccine and complications from 1980 to 2014. A total of 1147 articles were obtained out of which articles, which discuss the complications occurring orally or occurring elsewhere in the body, which have the potential to manifest orally after hepatitis B vaccination were selected. A total of 82 articles were identified which included 58 case series or case reports, 15 review articles, 4 cross sectional studies, 3 prospective cohort studies, one retrospective cohort study and a case control study. After reviewing the literature, we observed that complications seen after Hepatitis B vaccination are sudden infant death syndrome, multiple sclerosis, chronic fatigue syndrome, idiopathic thrombocytopenic purpura, vasculititis optic neuritis, anaphylaxis, systemic lupus erytymatosus, lichen planus and neuro-muscular disorder. Of these complications, some are manifested orally or have the potential to manifest orally. Although, most of the complications are self-limiting, some are very serious conditions, which require hospitalization with immediate medical attention.
A San Francisco judge cast doubt [recently] on a jurys $289 million damage award to a former Bay Area groundskeeper who was diagnosed with cancer after frequently spraying school grounds with a widely used weed-killer manufactured by Monsanto Co.
Superior Court Judge Suzanne Bolanos said in a tentative ruling that she would likely overturn $250 million in punitive damages because there was no convincing evidence that Monsanto had knowingly manufactured a harmful product or acted despicably toward the plaintiff, Dewayne Lee Johnson.
Bolanos did not announce a final ruling, but showed little indication during the hearing that she was reconsidering her tentative decision on punitive damages. Im not following your argument, she told Miller at one point after the lawyer said Monsanto had failed to properly test its product or study its effects.
by Bob Egelko
San Francisco Chronicle
Jurors who awarded $289 million to a former school groundskeeper who is dying of cancer are imploring a San Francisco judge to reconsider...
PMID: Vaccine. 2017 03 27 ;35(14):1758-1763. Epub 2017 Mar 3. PMID: 28262331 Abstract Title: Adverse events following quadrivalent meningococcal CRM-conjugate vaccine (Menveo) reported to the Vaccine Adverse Event Reporting system (VAERS), 2010-2015. Abstract: BACKGROUND: Limited data are available describing the post-licensure safety of meningococcal vaccines, including Menveo. We reviewed reports of adverse events (AEs) to the Vaccine Adverse Event Reporting System (VAERS) to assess safety in all age groups.METHODS: VAERS is a national spontaneous vaccine safety surveillance system co-administered by the Centers for Disease Control and Prevention and the US Food and Drug Administration. We searched the VAERS database for US reports of adverse events in persons who received Menveo from 1 January 2010 through 31 December 2015. We clinically reviewed reports and available medical records for serious AEs, selected pre-specified outcomes, and vaccination during pregnancy. We used empirical Bayesian data mining to identify AEs that were disproportionately reported after receipt of Menveo.RESULTS: During the study period, VAERS received 2614 US reports after receipt of Menveo. Of these, 67 were classified as serious, including 1 report of death. Adolescents (aged 11-18years) accounted for 74% of reports. Most of the reported AEs were non-serious and described AEs consistent with data from pre-licensure studies. Anaphylaxis and syncope were the two most common events in the serious reports. We did not identify any new safety concerns after review of AEs that exceeded the data mining threshold, although we did observe disproportionate reporting for terms that were not associated with an adverse event (e.g.,"incorrect drug dosage form administered","wrong technique in drug usage process"). Although reports were limited, we did not find any evidence for concern regarding the use of Menveo during pregnancy.CONCLUSIONS: In our review of VAERS reports, findings of AEs were consistent with the data from pre-licensure studies. Vaccine providers should continue to emphasize and adhere to proper administration of the vaccine.
PMID: Neurotoxicology. 2010 Sep ;31(5):575-81. Epub 2010 May 27. PMID: 20553758 Abstract Title: The neurotoxicity of environmental aluminum is still an issue. Abstract: Evidence for the neurotoxicity of extended exposure to low levels of aluminum salts is described using an animal model treated with aluminum at low levels reflecting those found in some water supplies. Emphasis is given to the potential role of aluminum in acceleration and promotion of some indices characteristic of brain aging. These hallmarks include the appearance of excess levels of inflammation in specific brain areas. Aluminum salts can increase levels of glial activation, inflammatory cytokines and amyloid precursor protein within the brain. Both normal brain aging and to a greater extent, Alzheimer's disease are associated with elevated basal levels of markers for inflammation. These are not attributable to obvious exogenous stimuli and may reflect the lifespan history of the organism's immune responses. It is possible that aluminum salts can act as a subtle promoter of such apparently unprovoked responses.
PMID: J Neural Transm (Vienna). 1998 ;105(1):59-68. PMID: 9588761 Abstract Title: Increased blood mercury levels in patients with Alzheimer's disease. Abstract: Alzheimer's disease (AD) is a common neurodegenerative disorder that leads to dementia and death. In addition to several genetic parameters, various environmental factors may influence the risk of getting AD. In order to test whether blood levels of the heavy metal mercury are increased in AD, we measured blood mercury concentrations in AD patients (n = 33), and compared them to age-matched control patients with major depression (MD) (n = 45), as well as to an additional control group of patients with various non-psychiatric disorders (n = 65). Blood mercury levels were more than two-fold higher in AD patients as compared to both control groups (p = 0.0005, and p = 0.0000, respectively). In early onset AD patients (n = 13), blood mercury levels were almost three-fold higher as compared to controls (p = 0.0002, and p = 0.0000, respectively). These increases were unrelated to the patients' dental status. Linear regression analysis of blood mercury concentrations and CSF levels of amyloid beta-peptide (A beta) revealed a significant correlation of these measures in AD patients (n = 15, r = 0.7440, p = 0.0015, Pearson type of correlation). These results demonstrate elevated blood levels of mercury in AD, and they suggest that this increase of mercury levels is associated with high CSF levels of A beta, whereas tau levels were unrelated. Possible explanations of increased blood mercury levels in AD include yet unidentified environmental sources or release from brain tissue with the advance in neuronal death.
PMID: Vaccine. 2018 09 25 ;36(40):5949-5954. Epub 2018 Aug 29. PMID: 30172632 Abstract Title: Cluster anxiety-related adverse events following immunization (AEFI): An assessment of reports detected in social media and those identified using an online search engine. Abstract: BACKGROUND: Adverse events following immunization (AEFI) arising from anxiety have rarely been reported as a cluster(s) in the setting of a mass vaccination program. Reports of clusters of anxiety-related AEFIs are understudied. Social media and the web may be a resource for public health investigators.METHODS: We searched Google and Facebook separately from Atlanta and Geneva to identify reports of cluster anxiety-related AEFIs. We reviewed a sample of reports summarizing year, country/setting, vaccine involved, patient symptoms, clinical management, and impact to vaccination programs.RESULTS: We found 39 reports referring to 18 unique cluster events. Some reports were only found based on the geographic location from where the search was performed. The most common vaccine implicated in reports was human papillomavirus (HPV) vaccine (48.7%). The majority of reports (97.4%) involved children and vaccination programs in school settings or as part of national vaccination campaigns. Five vaccination programs were reportedly halted because of these cluster events. In this study, we identified 18 cluster events that were not published in traditional scientific peer-reviewed literature.CONCLUSIONS: Social media and online search engines are useful resources for identifying reports of cluster anxiety-related AEFIs and the geographic location of the researcher is an important factor to consider when conducting these studies. Solely relying upon traditional peer-reviewed journals may seriously underestimate the occurrence of such cluster events.
PMID: Toxicology. 2014 Jan 6 ;315:1-7. Epub 2013 Nov 1. PMID: 24189189 Abstract Title: Prolonged exposure to low levels of aluminum leads to changes associated with brain aging and neurodegeneration. Abstract: Aluminum is one of the most common metal elements in the earth's crust. It is not an essential element for life and has commonly been thought of as a rather inert and insoluble mineral. Therefore, it has often been regarded as not posing a significant health hazard. In consequence, aluminum-containing agents been used in many food processing steps and also in removal by flocculation of particulate organic matter from water. In recent years, acid rain has tended to mobilize aluminum-containing minerals into a more soluble form, ionic Al(3+), which has found their way into many reservoirs that constitute residential drinking water resources. As a result, the human body burden of aluminum has increased. Epidemiological studies suggest that aluminum may not be as innocuous as was previously thought and that aluminum may actively promote the onset and progression of Alzheimer's disease. Epidemiological data is strengthened by experimental evidence of aluminum exposure leading to excess inflammatory activity within the brain. Such apparently irrelevant immune activity unprovoked by an exogenous infectious agent characterizes the aging brain and is even more pronounced in several neurodegenerative diseases. The causation of most of these age-related neurological disorders is not understood but since they are generally not genetic, one must assume that their development is underlain by unknown environmental factors. There is an increasing and coherent body of evidence that implicates aluminum as being one such significant factor. Evidence is outlined supporting the concept of aluminum's involvement in hastening brain aging. This acceleration would then inevitably lead to increased incidence of specific age-related neurological diseases.
Are you a horse lover? I think that sometimes we take for granted how smart these animals actually are. They are paying attention more than wed like to admit! This woman got a funny surprise from her beloved horse while she was trying- unsuccessfully- to mount him one day. Take a look at this video... View Article
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PMID: Infect Immun. 2000 Feb ;68(2):658-63. PMID: 10639430 Abstract Title: Occurrence of severe destructive lyme arthritis in hamsters vaccinated with outer surface protein A and challenged with Borrelia burgdorferi. Abstract: Arthritis is a frequent and major complication of infection with Borrelia burgdorferi sensu stricto. The antigens responsible for the induction of arthritis are unknown. Here we provide direct evidence that a major surface protein, outer surface protein A (OspA), can induce arthritis. Hamsters were vaccinated with 30, 60, or 120 microg of recombinant OspA (rOspA) in aluminum hydroxide and challenged with B. burgdorferi sensu stricto isolate 297 or C-1-11. Swelling of the hind paws was detected in 100, 100, and 50% of hamsters vaccinated with 30, 60, or 120 microg of rOspA, respectively. In addition, arthritis developed in 57% of hamsters vaccinated with a canine rOspA vaccine after infection with B. burgdorferi sensu stricto. When the canine rOspA vaccine was combined with aluminum hydroxide, all vaccinated hamsters developed arthritis after challenge with B. burgdorferi sensu stricto. Histopathologic examination confirmed the development of severe destructive arthritis in rOspA-vaccinated hamsters challenged with B. burgdorferi sensu stricto. These findings suggest that rOspA vaccines should be modified to eliminate epitopes of OspA responsible for the induction of arthritis. Our results are important because an rOspA vaccine in aluminum hydroxide was approved by the Food and Drug Administration for use in humans.
(Note from Erin: Thank you so much to David Stephan, VP of Operations at Truehope Canada, for bringing this story to our attention. We cannot imagine what Jeromie and Jennifer Clark are going through right now. Our hearts are breaking for them and we stand with them.) Also, according to David Stephan, there are a lot 
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PMID: Drug Chem Toxicol. 2009 ;32(3):215-21. PMID: 19538017 Abstract Title: Effect of concurrent chronic exposure of fluoride and aluminum on rat brain. Abstract: The present in vivo study was designed to investigate the toxic potential of fluoride alone and in conjugation with aluminum on the rat brain. The region-specific response of both elements was studied in different regions of brain, namely the cerebrum, cerebellum, and medulla oblongata. Following fluoride exposure, oxidative stress increased significantly, estimated by increased lipid peroxidation and a decrease in the activity of the antioxidant enzyme, superoxide dismutase. The neurotransmitter (e.g., dopamine, norepinephrine, and serotonin) content was also altered. However, these aspects were more pronounced in animals given fluoride and aluminum together. Histological evidence showed deprivation of neuronal integrity with higher magnitude in concurrent fluoride and aluminum exposure, as compared to fluoride alone. Thus, it can be concluded that aluminum appears to enhance the neurotoxic hazards caused by fluoride.
PMID: J Immunotoxicol. 2013 Apr-Jun;10(2):210-22. Epub 2012 Sep 11. PMID: 22967010 Abstract Title: How aluminum adjuvants could promote and enhance non-target IgE synthesis in a genetically-vulnerable sub-population. Abstract: Aluminum-containing adjuvants increase the effectiveness of vaccination, but their ability to augment immune responsiveness also carries the risk of eliciting non-target responses, especially in genetically susceptible individuals. This study reviews the relevant actions of aluminum adjuvants and sources of genetic risk that can combine to adversely affect a vulnerable sub-population. Aluminum adjuvants promote oxidative stress and increase inflammasome activity, leading to the release of IL-1, IL-18, and IL-33, but not the important regulatory cytokine IL-12. In addition, they stimulate macrophages to produce PGE, which also has a role in regulating immune responses. This aluminum-induced cytokine context leads to a T(H)2 immune response, characterized by the further release of IL-3, IL-4, IL-5, IL-9, IL-13, and IgE-potentiating factors such as sCD23. Genetic variants in cytokine genes, such as IL-4, IL-13, IL-33, and IL-18 influence the response to vaccines in children and are also associated with atopy. These genetic factors may therefore define a genetically-vulnerable sub-population, children with a family history of atopy, who may experience an exaggerated T(H)2 immune response to aluminum-containing vaccines. IL-4, sCD23, and IgE are common factors for both atopy and the immune-stimulating properties of aluminum adjuvants. IL-4 is critical in the production of IgEand total IgE up-regulation. IL-4 has also been reported to induce the production of sCD23 and trigger resting sIgM+, sIgD+ B-cells to switch to sIgE+ B-cells, making them targets for IgE-potentiating factors. Further, the actions of IgE-potentiating factors on sIgE+ B-cells are polyclonal and unrestricted, triggering their differentiation into IgE-forming plasma cells. These actions provide a mechanism for aluminum-adjuvant promotion and enhancement of non-target IgE in a genetically vulnerable sub-population. Identification of these individuals may decrease the risk of adverse events associated with the use of aluminum-containing vaccines.
PMID: Med J Aust. 2005 Aug 1 ;183(3):145-6. PMID: 16053418 Abstract Title: Macrophagic myofasciitis associated with vaccine-derived aluminium. Abstract: Macrophagic myofasciitis is characterised by sheets of macrophages in striated muscle, a few lymphocytes and inconspicuous muscle fibre damage. It is due to aluminium contained in vaccines, and is localised to the inoculation site. We report the first Australian case, detected incidentally when investigating a raised serum creatine kinase level.
PMID: Cell Physiol Biochem. 2018 ;49(3):1163-1179. Epub 2018 Sep 7. PMID: 30196282 Abstract Title: Ganoderma Lucidum Polysaccharide Peptide Alleviates Hepatoteatosis via Modulating Bile Acid Metabolism Dependent on FXR-SHP/FGF. Abstract: BACKGROUND/AIMS: Non-alcoholic fatty liver disease (NAFLD) encompasses a series of pathologic changes ranging from steatosis to steatohepatitis, which may progress to cirrhosis and hepatocellular carcinoma. The purpose of this study was to determine whether ganoderma lucidum polysaccharide peptide (GLPP) has therapeutic effect on NAFLD.METHODS: Ob/ ob mouse model and ApoC3 transgenic mouse model were used for exploring the effect of GLPP on NAFLD. Key metabolic pathways and enzymes were identified by metabolomics combining with KEGG and PIUmet analyses and key enzymes were detected by Western blot. Hepatosteatosis models of HepG2 cells and primary hepatocytes were used to further confirm the therapeutic effect of GLPP on NAFLD.RESULTS: GLPP administrated for a month alleviated hepatosteatosis, dyslipidemia, liver dysfunction and liver insulin resistance. Pathways of glycerophospholipid metabolism, fatty acid metabolism and primary bile acid biosynthesis were involved in the therapeutic effect of GLPP on NAFLD. Detection of key enzymes revealed that GLPP reversed low expression of CYP7A1, CYP8B1, FXR, SHP and high expression of FGFR4 in ob/ob mice and ApoC3 mice. Besides, GLPP inhibited fatty acid synthesis by reducing the expression of SREBP1c, FAS and ACC via a FXR-SHP dependent mechanism. Additionally, GLPP reduced the accumulation of lipid droplets and the content of TG in HepG2 cells and primary hepatocytes induced by oleic acid and palmitic acid.CONCLUSION: GLPP significantly improves NAFLD via regulating bile acid synthesis dependent on FXR-SHP/FGF pathway, which finally inhibits fatty acid synthesis, indicating that GLPP might be developed as a therapeutic drug for NAFLD.
This week, tests confirmed what residents and tourists on our side of the state have been complaining about: red tide had indeed struck the Space Coast, raising the specter of more dead fish, itchy throats, and beachside coughs. Although to be fair, the rancid fish carcasses on the beach should have been a dead giveaway, too. (And while 
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PMID: Food Chem. 2019 Jan 15 ;271:148-156. Epub 2018 Jul 18. PMID: 30236660 Abstract Title: Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis. Abstract: The hepatoprotective activity of ethanol extract of Ganoderma lucidum (GLE) in alcohol-induced liver injury in mice was investigated. HPLC coupled with photo-diode array detector and electrospray ionization-mass spectrometry was used to analyze the major triterpenoids in GLE. The effects of GLE on hepatoprotection were evaluated through histopathology and biochemical analysis of serum enzymes. We used isobaric tag for relative and absolute quantitation (iTRAQ) coupled with tandem mass spectrometry to identify differentially expressed liver proteome in mice. There were more than 4000 differentially expressed proteins; 40 proteins with the most significant changed proteins were applied for further bioinformatics analysis. Expression levels of cytochrome P450 2E1 and alcohol dehydrogenase 1, proteins that are closely associated with these processes, were validated by western blotting. Triterpenoids, major components of GLE, protected alcohol-induced liver injury through inhibiting lipid peroxidation, elevating activity of antioxidant enzymes, and suppressing apoptotic cell death and immune inflammatory response.
This story came out last month - but as flu shot season roars into Fall, it's important to note that not every healthcare provider agrees with getting flu shots. And associations are fighting back. Just as healthy children are being...
PMID: Int J Med Mushrooms. 2018 ;20(8):705-716. PMID: 30317947 Abstract Title: Randomized Clinical Trial for the Evaluation of Immune Modulation by Yogurt Enriched with-Glucans from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), in Children from Medellin, Colombia. Abstract: Pattern recognition receptor (PRR) agonists are promising for use in modulating immune responses in clinical settings characterized by immune immaturity or deficiency.-Glucans derived from Ganoderma lucidum have demonstrated immune-modulatory activity both in vitro and in vivo. To evaluate the immunomodulatory activity of orally administered -glucans, a randomized, double-blinded, placebo-controlled clinical study was performed in asymptomatic children, aged3 to 5 years old, from Medellin, Colombia. Primary outcomes were the circulating CD8+ T lymphocyte and natural killer cell counts; secondary outcomes were circulating lymphocyte counts (total, CD3+, and CD4+ T cells), serum concentrations of total immunoglobulin A and cytokines, and various hematological parameters. The treatments were administered daily for 12 weeks, and physical and laboratory evaluations were performed at days 0 and 84. Children in the group receiving a yogurt with -glucans presented a significantly higher absolute count of peripheral blood total lymphocytes (CD3+, CD4+,and CD8+ T cells) than that in the group receiving placebo. The interventions were safe and well tolerated; no abnormal increases in serum creatinine or hepatic aminotransferases occurred, and adherence was higher than 90% in the intervention groups. This study demonstrates that -glucans from G. lucidum increase the frequency of immune system cells in the peripheral blood; these cells are critical in the defense against infectious threats in asymptomatic children 3 to 5 years old. These findings warrant longer controlled clinical trials that aim to evaluate the efficacy of -glucans in preventing infections in healthy children and to define their potential to enhance lymphoid cell number and functions in various lymphoid immune deficiencies.
PMID: Int J Med Mushrooms. 2018 ;20(9):809-823. PMID: 30317976 Abstract Title: Protection against Gut Inflammation and Sepsis in Mice by the Autodigested Product of the Lingzhi Medicinal Mushroom, Ganoderma lingzhi (Agaricomycetes). Abstract: Ganoderma lingzhi (reishi) (GL) is a widely used medicinal mushroom in the treatment of several diseases, including metabolic syndrome and cancer. We recently performed autodigestion of GL and found enhanced release of hypotensive peptides and immunomodulating beta-1,3-glucan. In the present study, we examined the protective effects of G. lingzhi and its autodigested product (AD-GL) against gut inflammation and endogenous sepsis induced in mice by the oral administration of indomethacin (IND). Gut inflammation was assessed by measuring the lengths of the intestines and colon, and sepsis was evaluated by the survival period. G. lingzhi and AD-GL were mixed with animal feed (2.5%) that was available ad libitum during the experimental period. The murine model was established by the repeated oral administration of IND (once a day, 5 mg/kg from day 0). On day 3, the lengths of the small intestine and colon were measured, and the average lengths of the intestines were significantly shorter in the control and G. lingzhi-administered groups than in the AD-GL-administered group. This finding suggests that AD-GL protected against gut inflammation due to IND-induced ulceration and subsequent microbial translocation. Furthermore, the median numbers of survival days in the control group, the G. lingzhi group, and the AD-GL group were 5, 6, and 11, respectively. The concentrations of the inflammatory cytokines, tumor necrosis factor (TNF)- and interleukin-6, in the blood were significantly reduced in the mice administered AD-GL. In the in vitro cell culture, G. lingzhi and AD-GL fractions released a significantly higher concentration of TNF- from the spleen, and the splenocytes of mice administered AD-GL hot water extract showeda greater potential to produce cytokines in response to pathogen-associated molecular patterns. These results strongly suggest the protection of the gut mucosa from inflammation, and therefore the prevention of sepsis, by the administration of AD-GL. Autodigestion appears to be a promising protocolthat enhances the usefulness of G. lingzhi as a functional food.
PMID: Int J Med Mushrooms. 2018 ;20(8):761-774. PMID: 30317952 Abstract Title: Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), Prevents Doxorubicin-Induced Cardiotoxicity in Rats. Abstract: Doxorubicin (DOX) is an anticancer drug used extensively to treat a variety of human malignancies. DOX chemotherapy often leads to serious cardiotoxicity. We examined the ability of a Ganoderma lucidum extract (GLE) to prevent DOX-associated cardiotoxicity. DOX treatment of cardiac tissue drastically increased levels of creatine kinase (CK), lactate dehydrogenase (LDH), lipid peroxidation (thiobarbituric acid-reactive substances), advanced oxidation protein products (AOPPs), and protein carbonyls (PCOs), and significantly decreased reduced glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase activities. Administration of GLE restored CK, LDH, AOPPs, and PCOs to almost normal levels and significantly enhanced the activity of SOD, GPx, catalase, and GSH; it also downregulated lipid peroxidation. Histopathological observations, hematology profiles, and electrocardiography parameters supported the protective effect of GLE against cardiotoxicity associated with DOX treatment.
PMID: Oncotarget. 2016 11 15 ;7(46):75749-75762. PMID: 27716619 Abstract Title: Alpha fetoprotein antagonises benzyl isothiocyanate inhibition of the malignant behaviors of hepatocellular carcinoma cells. Abstract: Benzyl isothiocyanate (BITC) is a dietary isothiocyanate derived from cruciferous vegetables. Recent studies showed that BITC inhibited the growth of many cancer cells, including hepatocellular carcinoma (HCC) cells. Alpha-fetoprotein (AFP) is a important molecule for promoting progression of HCC, in the present investigation, we explore the influence of AFP on the role of BITC in the malignant behaviours of HCC cells, and the potential underlying mechanisms. We found thatBITC inhibited viability, migration, invasion and induced apoptosis of human liver cancer cell lines, Bel 7402(AFP producer) and HLE(non-AFP producer) cells in vitro. The role of BITC involve in promoting actived-caspase-3 and PARP-1 expression, and enhancing caspase-3 activity but decreasing MMP-2/9, survivin and CXCR4 expression. AFP antagonized the effect of BITC. This study suggests that BITC induced significant reductions in the viability of HCC cell lines. BITC may activate caspase-3 signal and inhibit the expression of growth- and metastasis-related proteins; AFP is an pivotal molecule for the HCC chemo-resistance of BITC.
The Brain And Stomach Are Connected In Ways You Never Imagined Lets be honest here. We have all found ourselves in a situation like this: We think that we are starving for food, and so we start to crave something fatty. Preferably something along the lines of pizza or cheap take-out. So what do we... View Article
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PMID: Oncotarget. 2017 Sep 8 ;8(38):63949-63962. Epub 2017 Jul 12. PMID: 28969043 Abstract Title: Isothiocyanates suppress the invasion and metastasis of tumors by targeting FAK/MMP-9 activity. Abstract: Isothiocyanates, which are present as glucosinolate precursors in cruciferous vegetables, have strong activity against various cancers. Here, we compared the anti-metastatic effects of isothiocyanates (benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and sulforaphane (SFN)) by examining how they regulate MMP-9 expression. Isothiocyanates, particularly PEITC, suppressed 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced MMP-9 activity and invasion in various cancer cell lines. By contrast, N-methyl phenethylamine, a PEITC analog without an isothiocyanate functional group, had no effect. A reporter gene assay demonstrated that BITC, PEITC, and SFN suppressed TAP-induced MMP-9 expression by inhibiting AP-1 and NF-B in U20S osteosarcoma cells. All three compounds reduced phosphorylation of FAK, ERK1/2, and Akt. In addition, MMP-9 expression was downregulated by inhibiting FAK, ERK1/2, and Akt. Isothiocyanates-mediated inhibition of FAK phosphorylation suppressed phosphorylation of ERK1/2 and Akt in U2OS andA549 cells, along with the translocation of p65 and c-Fos, suggesting that isothiocyanates inhibit MMP-9 expression and cell invasion by blocking phosphorylation of FAK. Furthermore, isothiocyanates, abolished MMP-9 expression and tumor metastasiswith the following efficacy: PEITC>BITC>SFN. Thus, isothiocyanates act as anti-metastatic compounds that suppress MMP-9 activity/expression by inhibiting NF-B and AP-1 via suppression of the FAK/ERK and FAK/Akt signaling pathways.
PMID: Environ Toxicol. 2018 Nov ;33(11):1097-1104. Epub 2018 Jul 4. PMID: 29972272 Abstract Title: Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo. Abstract: Benzyl isothiocyanate (BITC), a member of isothiocyanates (ITCs), has been shown to induce cell death in many human cancer cells, but there is no further report to show BITC suppresses glioblastoma multiforme cells in vivo. In the present study, we investigate the effects of BITC on the inhibition of GBM 8401/luc2 cell generated tumor on athymic nude mice. We established a luciferase expressing stable clone named as GBM 8401/luc2. Thirty male mice were inoculated subcutaneously with GBM 8401/luc2 cells to generate xenograft tumor mice model. Group I was treated with 110L phosphate-buffered solution plus 10 L dimethyl sulfoxide, Group II-III with BITC (5 or 10 mol/100 L/day, relatively). Mice were given oral treatment of BITC by gavage for 21 days. Results showed that BITC did not affect the body weights. After anesthetized, the photons emitted from mice tumor were detected with Xenogen IVIS imaging system 200 and higher dose of BITC have low total photon flux than that of lower dose of BITC. Results also showed that higher dose of BITC have low total tumor volumes and weights than that of low dose of BITC. Isolated tumors were investigated by immunohistochemical analysis and results showed that BITC at both dose of treatment weakly stained with anti-MCL1 and -XIAP. However, both dose of BITC treatments have strong signals of caspase-3 and Bax. Overall, these data demonstrated that BITC suppressed tumor properties in vivo. Overall, based on these observations, BITC can be used against human glioblastoma multiforme in the future.
PMID: Cholesterol. 2018 ;2018:6303810. Epub 2018 Aug 23. PMID: 30210871 Abstract Title: The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis. Abstract: Nutrient deficiencies and excess are involved in many aspects of human health. As a source of essential nutrients, eggs have been used worldwide to support the nutritional needs of human societies. On the other hand, eggs also contain a significant amount of cholesterol, a lipid molecule that has been associated with the development of cardiovascular diseases. Whether the increase of egg consumption will lead to elevated cholesterol absorption and disruption of cholesterol homeostasis has been a concern of debate for a while. Cholesterol homeostasis is regulated through its dietary intake, endogenous biosynthesis, utilization, and excretion. Recently, some research interests have been paid to the effects of egg consumption on cholesterol homeostasis through the intestinal cholesterol absorption. Nutrient components in eggs such as phospholipids may contribute to this process. The goals of this review are to summarize the recent progress in this area and to discuss some potential benefits of egg consumption.
Sometimes we hear about things on the newslike brain-eating amoebas, for instanceand we have a hard time believing theyre real. When Mia Mattioli, an environmental engineer, arrived in Waco, Texas, however, she was in search of exactly that: the Naegleria fowleri. This brain-eating, warm water-loving amoeba is a dangerous organism that, according to the Centers... View Article
We all have that friend who is constantly on their phone no matter what else is going on or who is talking. Some of us even have multiple of these friends, making it difficult to get anything done let alone have a full on conversation! Weve heard it said that social media is taking over... View Article
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